WO2023167114A1 - Composition nettoyante pour la peau - Google Patents

Composition nettoyante pour la peau Download PDF

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Publication number
WO2023167114A1
WO2023167114A1 PCT/JP2023/006889 JP2023006889W WO2023167114A1 WO 2023167114 A1 WO2023167114 A1 WO 2023167114A1 JP 2023006889 W JP2023006889 W JP 2023006889W WO 2023167114 A1 WO2023167114 A1 WO 2023167114A1
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mass
skin cleanser
cleanser composition
content
skin
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PCT/JP2023/006889
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English (en)
Japanese (ja)
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圭佑 吉田
亮 井上
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ライオン株式会社
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Publication of WO2023167114A1 publication Critical patent/WO2023167114A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the present invention relates to a skin cleanser composition.
  • skin cleansing compositions such as hand soaps and facial cleansers have sufficient bactericidal power, low irritation to the skin, and excellent usability (skin moistness and no squeakiness after use). , a makeup-removing effect, and an anti-inflammatory effect are desired.
  • a skin cleanser composition that has high bactericidal activity even when a low-concentration fatty acid salt is used, has excellent foam performance such as foam elasticity, good foaming, fineness of foam, etc., and is mild to the skin.
  • a skin cleanser composition containing a fatty acid salt, a cationic polymer, and an amino acid-based surfactant has been proposed (see, for example, Patent Document 1).
  • a skin cleansing composition for the purpose of imparting an excellent body odor suppressing effect (antibacterial performance), a skin cleansing composition has been proposed that combines polyoctanium-10, which is a cationic polymer, and salicylic acid, which is an antibacterial component ( For example, see Patent Document 2)
  • compositions described in Patent Documents 1 and 2 are sufficient in terms of sufficient makeup-removing effect, mildness, anti-inflammatory properties, and usability (skin moistness and no squeakiness after use). Needless to say, it was not satisfactory.
  • a skin cleansing composition that has both a makeup-removing effect and low irritation properties, and is excellent in moist feeling of the skin, absence of squeakiness of the skin, effect of reducing the amount of inflammatory cytokines, and high-temperature stability has not yet been provided.
  • the current situation is that there is a strong desire for its rapid development.
  • the object of the present invention is to solve the above-mentioned problems in the past and to achieve the following objects. That is, it is intended to provide a skin cleansing composition that achieves both a makeup-removing effect and low irritation properties, and is excellent in moist feeling of the skin, absence of skin squeakiness, effect of reducing the amount of inflammatory cytokines, and high-temperature stability. aim.
  • the skin cleanser composition of the present invention comprises (A) an anionic surfactant containing an amino acid-based surfactant, and (B) dimethyl chloride. At least one selected from a cationic polymer containing diallyl ammonium and a cationized polysaccharide, (C) at least one selected from salicylic acid or a salt thereof, and an ⁇ -hydroxy acid or a salt thereof, and (D) vitamin C It has been found that by containing a derivative and, it is possible to achieve both a makeup-removing effect and low irritation, and to have excellent skin moistness, no skin squeakiness, an effect of reducing the amount of inflammatory cytokines, and high-temperature stability. .
  • the present invention is based on the findings of the present inventors, and means for solving the above problems are as follows.
  • A an anionic surfactant containing an amino acid-based surfactant;
  • B at least one selected from cationic polymers containing dimethyldiallylammonium chloride and cationic polysaccharides;
  • C at least one selected from salicylic acid or a salt thereof and ⁇ -hydroxy acid or a salt thereof;
  • D a vitamin C derivative;
  • It is a skin cleanser composition characterized by containing ⁇ 2>
  • the component (B) is at least one cationic polymer selected from a dimethyldiallylammonium chloride polymer and a dimethyldiallylammonium chloride-acrylic acid copolymer,
  • the skin cleanser composition according to any one of ⁇ 1> to ⁇ 3>, wherein the molar ratio of structural units derived from dimethyldiallylammonium chloride in the dimethyldiallylammonium chloride-acrylic acid copolymer is 65% or more. It is a thing.
  • the content of the amino acid-based surfactant is 1% by mass or more and 10% by mass or less with respect to the total amount of the skin cleanser composition
  • the content of the component (B) is 0.3% by mass or more and 0.8% by mass or less with respect to the total amount of the skin cleanser composition
  • the content of the component (C) is 0.1% by mass or more and 1% by mass or less with respect to the total amount of the skin cleanser composition
  • the skin cleanser according to any one of ⁇ 1> to ⁇ 4>, wherein the content of the component (D) is 0.01% by mass or more and 1% by mass or less based on the total amount of the skin cleanser composition. composition.
  • ⁇ 6> Further containing a higher fatty acid salt, The skin cleanser composition according to any one of ⁇ 1> to ⁇ 5>, wherein the content of the higher fatty acid salt is 5% by mass or more and 15% by mass or less based on the total amount of the skin cleanser composition. be. ⁇ 7> The skin cleanser composition according to any one of ⁇ 1> to ⁇ 6>, which is filled in a foamer container.
  • the above-mentioned problems in the conventional art can be solved and the above-mentioned objects can be achieved. can be provided.
  • the skin cleanser composition of the present invention comprises at least one selected from (A) an anionic surfactant containing an amino acid-based surfactant, and (B) a cationic polymer containing dimethyldiallylammonium chloride, and a cationized polysaccharide. (C) at least one selected from salicylic acid or a salt thereof and ⁇ -hydroxy acid or a salt thereof; and (D) a vitamin C derivative, and optionally other ingredients.
  • an anionic surfactant containing an amino acid-based surfactant is selected from “(A) component", (B) a cationic polymer containing dimethyldiallylammonium chloride, and a cationized polysaccharide. At least one selected from “(B) component”, (C) salicylic acid or its salt, and ⁇ -hydroxy acid or its salt is “(C) component", (D) vitamin The C derivative may be referred to as "(D) component".
  • the (A) anionic surfactant containing an amino acid-based surfactant is mainly contained to improve the makeup-removing effect.
  • amino acid-based surfactant is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include compounds represented by the following general formula (A4).
  • the amino acid-based surfactants may be used singly or in combination of two or more.
  • R 2 is substituted with a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms, or a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms.
  • the number of carbon atoms in the R 2 moiety is preferably 8 to 18.
  • R 4 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.
  • R 5 and R 6 may be the same or different and represent a hydrogen atom or —(CH 2 ) m —COOM 2 .
  • m and n may be the same or different and each represents a number of 0-20.
  • M 1 and M 2 may be the same or different and represent a hydrogen atom, alkali metal, alkaline earth metal, alkanolamine, ammonium, or basic amino acid.
  • the amino acid structure of the hydrophilic portion of the amino acid-based surfactant is not particularly limited and can be appropriately selected according to the purpose, but glycine, glutamic acid, and methylalanine are preferred.
  • amino acid surfactant represented by the general formula (A4) include N-acyl-glycine such as N-cocoyl-glycine potassium (N-coconut fatty acid acylglycine potassium) and salts thereof, N- N-acyl-N-carboxyethyl-glycine such as sodium myristoyl-N-carboxyethyl-glycine and salts thereof, sodium N-myristoyl-L-glutamate, potassium N-myristoyl-L-glutamate, N-coconut fatty acid acyl- Potassium L-glutamate, N-acyl glutamic acid such as sodium N-palm fatty acid-L-glutamate, sodium N-stearoyl-L-glutamate and salts thereof, N-lauroyl-N-methyl- ⁇ -alanine potassium, N-lauroyl -N-methyl- ⁇ -alanine such as N-methyl- ⁇ -alanine triethanolamine, N-acyl-glycine potassium
  • the content of the amino acid-based surfactant is not particularly limited and can be appropriately set according to the purpose. is preferably 0.5% by mass or more and 20% by mass or less, more preferably 1% by mass or more and 10% by mass or less. If the content of the amino acid-based surfactant is 0.5% by mass or more relative to the total amount of the skin cleanser composition, the makeup-removing effect may be insufficient, or the skin may be more irritated. It is preferable because it can eliminate When the content of the amino acid-based surfactant is 20% by mass or less relative to the total amount of the skin cleanser composition, problems such as poor high-temperature stability and increased skin irritation can be resolved. Therefore, it is preferable.
  • amino acid-based surfactant an appropriately synthesized one may be used, or a commercially available product may be used.
  • Commercially available amino acid-based surfactants include, for example, trade names of Amylite (registered trademark) GCK-11 (N-coconut oil fatty acid acylglycine potassium liquid) and Amilite (registered trademark) GCK-12K (N-coconut oil fatty acid potassium liquid).
  • Oil fatty acid acylglycine potassium liquid Amylite (registered trademark) GCS-12K (N-coconut fatty acid acylglycine sodium liquid), Amylite (registered trademark) GCS-11 (N-coconut fatty acid acylglycinate sodium), Amisoft (registered Trademark) CS-11 (N-acyl-L-glutamate sodium), Amisoft (registered trademark) LS-11 (N-acyl-L-glutamate sodium), Amisoft (registered trademark) MS-11 (N-acyl-L- Sodium glutamate), Amisoft (registered trademark) HS-11P (N-stearoyl-L-sodium glutamate), Amisoft (registered trademark) HS-11P (F) (N-stearoyl-L-sodium glutamate), Amilite (registered trademark) ACS-12 (N-coconut oil fatty acid acyl-L-alanine sodium solution) (manufactured by Ajin
  • the skin cleanser composition of the present invention may contain an anionic surfactant other than the amino acid-based surfactant, in addition to the amino acid-based surfactant.
  • an anionic surfactant other than the said amino acid type surfactant may be called "other anionic surfactant.”
  • the other anionic surfactants are not particularly limited and can be appropriately selected according to the purpose. Examples thereof include higher fatty acid salts, polyoxyethylene alkyl ether sulfates, ether carboxylic acid surfactants, and the like. . These may be used individually by 1 type, and may use 2 or more types together.
  • the higher fatty acid salt is not particularly limited and can be appropriately selected according to the purpose.
  • Examples include laurate, myristate, palmitate, and stearate.
  • laurate and myristate are preferred from the viewpoint of improving the effect of removing makeup and reducing the amount of inflammatory cytokines. These may be used individually by 1 type, and may use 2 or more types together.
  • the salt in the higher fatty acid salt is not particularly limited and can be appropriately selected depending on the intended purpose.
  • examples thereof include alkali metal salts, amine salts, amino acid salts and the like.
  • the alkali metal salt is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include sodium salt and potassium salt.
  • the amine salt is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include alkanolamine salts such as amino-2-methylpropanediol.
  • the amino acid salt is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include lysine salts and arginine salts. Among these, alkali metal salts are preferred, and potassium salts are more preferred.
  • the polyoxyethylene alkyl ether sulfate is not particularly limited and can be appropriately selected according to the purpose. Examples include polyoxyethylene (1) sodium lauryl ether sulfate, polyoxyethylene (2) sodium lauryl ether sulfate, Polyoxyethylene (3) sodium lauryl ether sulfate, polyoxyethylene (4) sodium lauryl ether sulfate, polyoxyethylene (5) sodium lauryl ether sulfate, polyoxyethylene (3) alkyl (C12,13) sodium ether sulfate, poly Oxyethylene (2) ammonium lauryl ether sulfate, polyoxyethylene (3) ammonium lauryl ether sulfate, and the like.
  • the numerical value in said () represents the average added mole number (n) of ethylene oxide. These may be used individually by 1 type, and may use 2 or more types together.
  • the ether carboxylic acid-based surfactant is not particularly limited and can be appropriately selected according to the purpose. Examples include polyoxyethylene (3) sodium lauryl ether acetate, polyoxyethylene (4) potassium lauryl ether acetate, and sodium lauryl glycol acetate.
  • the numerical value in said () represents the average added mole number (n) of ethylene oxide. These may be used individually by 1 type, and may use 2 or more types together.
  • the content of the laurate is not particularly limited and can be appropriately set according to the intended purpose. More preferably, the content is 16% by mass or less.
  • the content of the myristate salt is not particularly limited and can be appropriately set according to the purpose. % by mass or more and 6% by mass or less is more preferable.
  • the content of the higher fatty acid salt is not particularly limited and can be appropriately set according to the intended purpose. 20 mass % or less is preferable, and 5 mass % or more and 15 mass % or less is more preferable.
  • the content of the higher fatty acid salt is 2% by mass or more relative to the total amount of the skin cleanser composition, the problem of insufficient makeup-removing effect can be solved, which is preferable.
  • the content of the higher fatty acid salt is 20% by mass or less relative to the total amount of the skin cleanser composition, the problem of increased irritation to the skin can be eliminated, which is preferable.
  • higher fatty acid salt an appropriately synthesized one may be used, or a commercially available product may be used.
  • commercially available higher fatty acid salts include NIKKOL potassium laurate LK-120 (potassium laurate) and NIKKOL potassium myristate MK-140 (potassium myristate) (manufactured by Nikko Chemicals Co., Ltd.). .
  • a higher fatty acid salt may be synthesized by neutralizing a higher fatty acid and an alkali such as potassium hydroxide in a blending tank.
  • potassium laurate may be prepared by neutralizing lauric acid (NAA-122, manufactured by NOF Corporation) with potassium hydroxide (liquid caustic potash, manufactured by AGC Corporation).
  • potassium myristate may be prepared by neutralizing myristic acid (NAA-142, manufactured by NOF Corporation) with potassium hydroxide (liquid caustic potash, manufactured by AGC Corporation).
  • the amino acid-based surfactant and the other anionic surfactant are used from the viewpoint of improving the effect of removing makeup and the effect of reducing the amount of inflammatory cytokines. It is preferable to use together with.
  • the cationic polymer is not particularly limited as long as it contains dimethyldiallylammonium chloride and can be appropriately selected according to the purpose. (dimethyldiallylammonium chloride-acrylic acid copolymer), but from the viewpoint of imparting a moist feeling to the skin, it is preferably a dimethyldiallylammonium chloride polymer.
  • the dimethyldiallylammonium chloride-acrylic acid copolymer is represented by the following general formula (B1).
  • n and m represent the molar ratio (mol%) of each structural unit.
  • the molar ratio of structural units derived from dimethyldiallylammonium chloride in the dimethyldiallylammonium chloride-acrylic acid copolymer is preferably 65 mol% or more, more preferably 95 mol% or more.
  • the molar ratio of structural units derived from dimethyldiallylammonium chloride in the dimethyldiallylammonium chloride-acrylic acid copolymer is 65 mol% or more, it is possible to obtain a skin cleanser composition that provides excellent skin moistness. can.
  • the dimethyldiallylammonium chloride-acrylic acid copolymer may be used alone or in combination of two or more.
  • the molar ratio of each structural unit in the dimethyldiallylammonium chloride-acrylic acid copolymer can be determined by nuclear magnetic resonance (NMR) measurement under the following measurement conditions.
  • NMR nuclear magnetic resonance
  • Solvent heavy water ( D2O )
  • Measuring instrument JNM-LA300 (300 MHz, manufactured by JEOL Ltd.)
  • the weight-average molecular weight of the cationic polymer is not particularly limited and can be appropriately selected depending on the intended purpose. preferable.
  • the weight average molecular weight of the cationic polymer can be measured, for example, with a SEC-MALLS-RI system (measurement conditions: column: TSKgel ⁇ series ⁇ -M column 30 cm manufactured by Tosoh Corporation, solvent: sodium nitrate 0.3 M aqueous solution). can.
  • the viscosity at 25° C. of a solution of the cationic polymer having a solid content of 30% by mass to 44% by mass is preferably 10 mPa ⁇ s or more and 15,000 mPa ⁇ s or less, more preferably 20 mPa ⁇ s or more and 12,000 mPa ⁇ s or less.
  • the viscosity can be measured, for example, using a Brookfield viscometer LVF (manufactured by Brookfield).
  • the cationic polymer may be appropriately synthesized or may be a commercially available product.
  • Commercially available cationic polymers include, for example, trade names of MERQUAT 100 (dimethyldiallylammonium chloride polymer), MERQUAT 280 (dimethyldiallylammonium chloride-acrylic acid copolymer), MERQUAT 295 (dimethyl chloride diallyl ammonium-acrylic acid copolymer), Marquat 550PR (dimethyl diallyl ammonium chloride-acrylamide copolymer) (both manufactured by Lubrizol), and the like.
  • the composition, physical properties, etc. of each commercial product are shown below.
  • the cationic polysaccharide is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include cationic cellulose and cationic guar gum.
  • the cationized polysaccharide may be appropriately synthesized or may be a commercially available product.
  • Examples of commercial products of the cationic polysaccharide include Leoguard GP (polyquaternium 10, manufactured by Lion Specialty Chemicals), JAGUAR C145 (cationized guar gum, manufactured by Sansho Kasei), Lavor gum CG-M (DSP Gokyo Food & Chemical Co., Ltd.).
  • a dimethyldiallyl ammonium chloride polymer as the component (B).
  • the content of component (B) is not particularly limited and can be appropriately selected according to the intended purpose. is preferably 0.2% by mass or more and 1.5% by mass or less, more preferably 0.3% by mass or more and 0.8% by mass or less. When the content of component (B) is 0.2% by mass or more relative to the total amount of the skin cleanser composition, it is possible to solve the problem of insufficient skin moistness, which is preferable. . When the content of the component (B) is 1.5% by mass or less relative to the total amount of the skin cleanser composition, it is possible to solve the problem that the skin does not feel squeaky, which is preferable. be.
  • Salicylic acid or its salt - The salt of salicylic acid or a salt thereof is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include alkali metal salts.
  • the alkali metal salt is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include sodium salt and potassium salt.
  • Salicylic acid or a salt thereof may be appropriately synthesized or a commercially available product.
  • Examples of commercially available salicylic acid or salts thereof include salicylic acid (manufactured by API Corporation).
  • ⁇ -hydroxy acid or its salt is not particularly limited and can be appropriately selected according to the purpose. Examples include malic acid or its salt, glycolic acid or its salt, lactic acid or its salt, tartaric acid or its salt, and the like. is mentioned. These may be used individually by 1 type, and may use 2 or more types together.
  • the salt in the ⁇ -hydroxy acid or salt thereof is not particularly limited and can be appropriately selected according to the purpose, and examples thereof include alkali metal salts.
  • the alkali metal salt is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include sodium salt and potassium salt.
  • ⁇ -hydroxy acid or salt thereof an appropriately synthesized one may be used, or a commercially available product may be used.
  • Commercially available ⁇ -hydroxy acids or salts thereof include, for example, the trade names of Fuso Malate, DL-Sodium Malate, Fermented Lactic Acid 90, L-Tartaric Acid (manufactured by Fuso Chemical Industry Co., Ltd.), and Glycolic Acid. 50% cyclosystem complex (manufactured by H-Holstein) and the like.
  • the content of the component (C) is 0.01% by mass or more and 3% by mass or less with respect to the total amount of the skin cleanser composition, from the viewpoint of reducing the amount of inflammatory cytokines and improving mildness. It is preferably 0.1% by mass or more and 1% by mass or less.
  • the content of the component (C) is 0.01% by mass or more relative to the total amount of the skin cleanser composition, the problem of insufficient effect of reducing the amount of inflammatory cytokines can be solved, which is preferable. is.
  • the content of the component (C) is 3% by mass or less relative to the total amount of the skin cleanser composition, the problem of increased irritation to the skin can be eliminated, which is preferable.
  • the (D) vitamin C derivative is contained in order to improve the effect of reducing the amount of inflammatory cytokines.
  • the (D) vitamin C derivative is not particularly limited and can be appropriately selected depending on the intended purpose.
  • -2-phosphate-6-sodium palmitate, ascorbyl dipalmitate, and ascorbyl tetrahexyldecanoate are preferred from the viewpoint of improving the effect of reducing the amount of inflammatory cytokines.
  • sodium ascorbyl phosphate is preferred from the viewpoint of improving the effect of reducing the amount of inflammatory cytokines.
  • These may be used individually by 1 type, and may use 2 or more types together.
  • the content of component (D) is not particularly limited and can be appropriately set according to the purpose. is preferably 0.001% by mass or more and 5% by mass or less, more preferably 0.01% by mass or more and 1% by mass or less.
  • the content of component (D) is 0.001% by mass or more relative to the total amount of the skin cleanser composition, the problem of insufficient effect of reducing the amount of inflammatory cytokines can be solved, which is preferable. is.
  • the content of component (D) is 5% by mass or less relative to the total amount of the skin cleanser composition, the problem of poor high-temperature stability can be eliminated, which is preferable.
  • the (D) component may be appropriately synthesized or may be a commercially available product.
  • Commercially available products of component (D) include, for example, the trade names of PS ascorbate (sodium ascorbyl phosphate) and Aprecie (registered trademark) (sodium ascorbate-2-phosphate-6-palmitate) (above, Showa Denko Co., Ltd.), EPC (SENJU) ((ascorbyl/tocopheryl) potassium phosphate) (Senju Pharmaceutical Co., Ltd.), AA2G (ascorbyl glucoside) (Hayashibara Co., Ltd.), NIKKOL CP (ascorbyl dipalmitate), NIKKOL VC- PMG (magnesium ascorbyl phosphate), NIKKOL VC-IPV (ascorbyl tetrahexyldecanoate) (manufactured by Nikko Chemicals Co., Ltd.) and the like.
  • the mass ratio [(A)/(B)] of the content of the component (A) to the content of the component (B) is not particularly limited and may be selected depending on the purpose. Although it can be set as appropriate, it is preferably 22 or more and 40 or less, more preferably 26 or more and 32 or less, from the viewpoint of improving the effect of reducing the amount of inflammatory cytokines.
  • the content mass ratio [(A)/(B)] is 22 or more, it is possible to solve the problem that the effect of reducing the amount of inflammatory cytokines is insufficient, which is preferable.
  • the content mass ratio [(A)/(B)] is 40 or less, it is possible to solve the problem that the effect of reducing the amount of inflammatory cytokines is insufficient, which is preferable.
  • the mass ratio [(B)/(C)] of the content of the component (B) to the content of the component (C) is not particularly limited and may be selected depending on the purpose. Although it can be set as appropriate, it is preferably 0.3 or more and 6 or less, more preferably 0.6 or more and 1.5 or less, from the viewpoint of improving the effect of reducing the amount of inflammatory cytokines and improving low irritation. preferable.
  • the content mass ratio [(B)/(C)] is 0.3 or more, problems such as insufficient effect of reducing the amount of inflammatory cytokines and increased skin irritation are solved. It is suitable because it can be eliminated.
  • the mass ratio [(B)/(C)] of the contents is 6 or less, it is possible to solve the problem that the effect of reducing the amount of inflammatory cytokines is insufficient, which is preferable.
  • the skin cleansing composition of the present invention requires components within a range that does not impair the effects of the present invention.
  • Other ingredients can be added depending on the requirements.
  • the other components include surfactants other than the component (A), water-soluble solvents, water-soluble polymers other than the component (B), oils, silicones, alcohols such as lower or higher alcohols, Lanolin derivatives, protein derivatives, amino acids, drugs such as vitamins other than component (D), disinfectants, moisturizers, preservatives, pH adjusters, antioxidants, sequestering agents, UV absorbers, UV scattering agents , animal and plant extracts or derivatives thereof, chelating agents, dyes, fragrances, pigments, inorganic powders, clay minerals, water-insoluble polymer compound powders, and the like.
  • the content of the other components in the skin cleanser composition is not particularly limited and can be appropriately selected according to the purpose.
  • Surfactants other than the component (A) are not particularly limited and can be appropriately selected according to the purpose. Examples thereof include nonionic surfactants and amphoteric surfactants.
  • Nonionic surfactant is contained in order to impart a moist feeling to the skin after using the skin cleanser composition and to improve storage stability.
  • the nonionic surfactant is not particularly limited and can be appropriately selected according to the intended purpose. Examples thereof include POE alkyl ether type nonionic surfactants.
  • Examples of the POE alkyl ether type nonionic surfactant include polyoxyethylene (5) behenyl ether, polyoxyethylene (10) behenyl ether, polyoxyethylene (5) octyldodecyl ether, polyoxyethylene (10) octyldodecyl ether, polyoxyethylene (5) decyltetradecyl ether, polyoxyethylene (20) decyltetradecyl ether, and the like.
  • the numerical value in said () represents the average added mole number (n) of ethylene oxide.
  • the content of the nonionic surfactant is not particularly limited and can be appropriately set according to the purpose, but is preferably 1% by mass or more and 20% by mass or less based on the total amount of the skin cleanser composition.
  • amphoteric surfactant is contained in order to prevent the skin from feeling taut after using the skin cleanser composition and to improve storage stability.
  • the amphoteric surfactant is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include amidobetaine type amphoteric surfactants and alkylbetaine type amphoteric surfactants.
  • the amidobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the intended purpose. mentioned.
  • the alkylbetaine type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the intended purpose.
  • amphoteric surfactant examples thereof include betaine lauryldimethylaminoacetate, coconut oil alkylbetaine, and betaine stearyldimethylaminoacetate.
  • the content of the amphoteric surfactant is not particularly limited and can be appropriately set according to the purpose, but is preferably 1% by mass or more and 20% by mass or less based on the total amount of the skin cleanser composition.
  • the water-soluble solvent is contained in order to impart a moist feeling to the skin after use of the skin cleansing composition and to improve storage stability.
  • the water-soluble solvent is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include glycerin, sorbitol, propylene glycol and 1,3-butylene glycol.
  • the content of the water-soluble solvent is not particularly limited and can be appropriately set according to the purpose, but is preferably 1% by mass or more and 30% by mass or less based on the total amount of the skin cleanser composition.
  • oils and fats such as oils and their ester compounds: animal oils and fats such as mink oil and egg yolk oil, waxes such as beeswax, whale wax, lanolin, hydrogenated lanolin, carnauba wax and candelilla wax, liquid paraffin, squalane, micro Crystalline wax, ceresin wax, paraffin wax, hydrocarbons such as petrolatum, natural and synthetic fatty acids such as oleic acid, isostearic acid, behenic acid: glycerol tri-2-ethylhexanoate, 2-ethylhexyl stearate, stearic acid butyl, isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, octyldodecyl oleate, esters such as cholesterol oleate, and the like.
  • animal oils and fats such as mink oil and egg yolk oil, waxes such as bee
  • the alcohols are not particularly limited and can be appropriately selected according to the purpose. Examples include natural and synthetic higher alcohols such as cetyl alcohol, oleyl alcohol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol, and the like. mentioned.
  • the content of the alcohol is not particularly limited and can be appropriately set according to the purpose, but is preferably 0.1% by mass or more and 10% by mass or less with respect to the total amount of the skin cleanser composition.
  • the moisturizing agent is not particularly limited and can be appropriately selected depending on the intended purpose. .), diglycerin, triglycerin, polyglycerin and the like.
  • the content of the moisturizing agent is not particularly limited and can be appropriately set according to the purpose, but is preferably 0.05% by mass or more and 10% by mass or less based on the total amount of the skin cleanser composition.
  • the preservative is not particularly limited and can be appropriately selected depending on the intended purpose. '-Hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, benzalkonium chloride, hinokitiol, resorcinol, methylchloroisothiazolinone/methylisothiazolinone liquid (trade name: Kason CG, Rohm & Haas Co., Ltd.) Japan), pentanediol, phenoxyethanol, ethanol and the like.
  • the content of the antiseptic is not particularly limited and can be appropriately set according to the purpose, but is preferably 0.1% by mass or more and 1% by mass or less based on the total amount of the skin cleanser composition.
  • the antioxidant is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include dibutylhydroxytoluene, butylhydroxyanisole, and ascorbic acid.
  • the content of the antioxidant is not particularly limited and can be appropriately set according to the purpose, but is preferably 0.1% by mass or more and 1% by mass or less based on the total amount of the skin cleanser composition.
  • the chelating agent is not particularly limited and can be appropriately selected depending on the intended purpose. Examples thereof include disodium edetate, ethylenediaminetetraacetate, hexametaphosphate and gluconic acid.
  • the content of the chelating agent is not particularly limited and can be appropriately set according to the purpose, but is preferably 0.1% by mass or more and 1% by mass or less based on the total amount of the skin cleanser composition.
  • the pH adjuster is not particularly limited and can be appropriately selected depending on the intended purpose. acid, glycolic acid, and the like. Among these, potassium hydroxide is preferred.
  • the ultraviolet absorber and the ultraviolet scattering agent are not particularly limited and can be appropriately selected depending on the intended purpose. , and talc.
  • the content of the ultraviolet absorber and the ultraviolet scattering agent is not particularly limited and can be appropriately set according to the purpose. is preferred.
  • Vitamins other than the component (D) are not particularly limited and can be appropriately selected according to the purpose. , carnitine, ferulic acid, ⁇ -oryzanol, ⁇ -lipoic acid, orotic acid and derivatives thereof.
  • the content of vitamins other than the component (D) is not particularly limited and can be appropriately set according to the purpose. % by mass or less is preferable.
  • amino acids are not particularly limited and can be appropriately selected depending on the intended purpose. Examples include arginine, histidine, lysine and derivatives thereof.
  • the content of the amino acids is not particularly limited and can be appropriately set according to the purpose, but is preferably 0.001% by mass or more and 0.5% by mass or less based on the total amount of the skin cleanser composition.
  • the water-insoluble polymer compound powder is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include nylon and polyethylene. These may be used individually by 1 type, and may use 2 or more types together.
  • the content of the water-insoluble polymer compound powder is not particularly limited and can be appropriately set according to the purpose. is preferred.
  • the pH of the skin cleanser composition of the present invention at 25°C is preferably 9-11.
  • the method for measuring the pH is not particularly limited, but for example, after the skin cleanser composition is kept at a constant temperature of 25°C, it is measured at 25°C for 3 minutes using a pH meter (HM-30R, manufactured by TOA DKK). A method of measuring the subsequent value, and the like.
  • the viscosity at 25° C. of the skin cleanser composition of the present invention is not particularly limited and can be appropriately selected according to the purpose, but is preferably 3 mPa ⁇ s or more and 30 mPa ⁇ s or less.
  • the method for measuring the viscosity is not particularly limited. and a method of measuring the viscosity after 1 minute with one rotor.
  • the skin cleanser composition of the present invention may be of a type that is filled in a foamer container and discharged in a foamy form.
  • the foamer container is not particularly limited as long as it can discharge the skin cleanser composition in the form of foam, and can be appropriately selected according to the purpose. and an aerosol container using a container. Among these, a non-gas type bubble dispenser is preferred.
  • the non-gas type foam dispenser is not particularly limited as long as it can mix the skin cleanser composition with air and discharge it in a foamed state.
  • Examples include a squeeze foamer container capable of discharging foam by squeezing the body portion by hand, and a pump foaming container capable of discharging foam by pushing down the nozzle portion.
  • a squeeze foamer container and the pump foamer container for example, a foamer container manufactured by Yamato Seikan Co., Ltd., a foamer container manufactured by Yoshino Kogyosho Co., Ltd., and the like can be used. More specifically, the former containers described in JP-A-7-315463, JP-A-8-230961, and JP-A-2005-193972 can be used.
  • the non-gas type foam dispenser usually has a porous membrane for forming foam, and foam is formed by passing the skin cleanser composition through the porous membrane.
  • the material of the porous membrane is not particularly limited and can be appropriately selected depending on the purpose, but plastic materials such as nylon, polyester, polyolefin, etc. are preferable.
  • the mesh of the porous membrane is not particularly limited and can be appropriately selected according to the purpose. is more preferred.
  • the number of the porous membranes is not particularly limited and can be appropriately selected depending on the purpose, but from the viewpoint of improving foam performance, 2 to 4 are preferable.
  • the viscosity of the skin cleansing composition at the temperature is preferably 30 mPa ⁇ s or less, more preferably 25 mPa ⁇ s or less.
  • the method for producing the skin cleanser composition of the present invention is not particularly limited and can be appropriately selected according to the purpose. It can be obtained by mixing component D), optionally the other components, and purified water (blended as the remaining amount so that the total amount of the skin cleanser composition is 100% by mass). Specifically, it can be manufactured as follows. After dissolving the (A) component and the (C) component in purified water heated to 70 ° C. to 80 ° C., cooling to 40 ° C. or less, the (B) component, the (D) component, And it can be produced by adding the above other components.
  • the skin cleanser composition may be prepared using an apparatus.
  • the device is not particularly limited and can be appropriately selected according to the purpose.
  • the stirring blade is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include propellers, turbines, and dispersers.
  • the site and method of use of the skin cleanser composition are not particularly limited and can be appropriately selected according to the intended purpose.
  • the use of the skin cleanser composition is not particularly limited and can be appropriately selected according to the intended purpose. mentioned. Among these, facial cleansing foam is preferred.
  • Examples 1 to 19 and Comparative Examples 1 to 4 Skin cleansing compositions having compositions and contents shown in Tables 1 to 5 below were prepared by the following method. Purified water was heated to 70° C. to 80° C. to dissolve the components (A) and (C) in an amount of 95% by mass of the total skin cleanser composition finally obtained. Thereafter, the mixture was cooled to 40° C. or below, and the components (B), (D) and other components were added to prepare a skin cleanser composition. After that, if the pH is less than the predetermined value, potassium hydroxide, which is another component, is added to adjust the pH to 10.0, and then purified water is added so that the total amount becomes 100% by mass.
  • potassium hydroxide which is another component
  • the skin cleanser compositions of Examples 1 to 19 and Comparative Examples 1 to 4 were obtained.
  • the mixture was stirred using a three-one motor (HEIDON BL1200, manufactured by Shinto Kagaku Co., Ltd.), and a propeller was used as the stirring blade.
  • the obtained skin cleanser compositions of Examples 1 to 19 and Comparative Examples 1 to 4 were filled in a container with a foamer pump dispenser (discharge volume 1 mL, manufactured by Yoshino Kogyosho Co., Ltd.).
  • the skin cleanser composition of the present invention achieves both a makeup-removing effect and low irritation properties, and is excellent in skin moist feeling, absence of skin squeakiness, effect of reducing the amount of inflammatory cytokines, and high-temperature stability. , body shampoo, body soap, facial cleansing foam, hand soap, foaming hand soap cleansing foam, make-up remover and the like.

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Abstract

Cette composition nettoyante pour la peau est caractérisée en ce qu'elle comprend : (A) un tensioactif anionique contenant un tensioactif à base d'acide aminé ; (B) au moins un élément choisi parmi un polymère cationique contenant du chlorure de diméthyldiallylammonium et un polysaccharide cationisé ; (C) au moins un élément choisi parmi un acide salicylique ou un sel de celui-ci et un acide α-hydroxy ou un sel de celui-ci ; et (D) un dérivé de vitamine C.
PCT/JP2023/006889 2022-03-04 2023-02-24 Composition nettoyante pour la peau WO2023167114A1 (fr)

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JP2022033665A JP2023128960A (ja) 2022-03-04 2022-03-04 皮膚洗浄剤組成物
JP2022-033665 2022-03-04

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501709A (ja) * 2009-07-17 2013-01-17 レキット ベンキサー ヘルスケア インターナショナル リミテッド スキンケア組成物
US20180140541A1 (en) * 2016-11-22 2018-05-24 Truezyme Co., Ltd. Fermented composition for preventing hair loss and promoting hair growth containing natural extracts
JP2020172476A (ja) * 2019-04-12 2020-10-22 ライオン株式会社 液体皮膚洗浄剤組成物
JP2020203840A (ja) * 2019-06-14 2020-12-24 ライオン株式会社 液体皮膚洗浄剤組成物
JP2021091641A (ja) * 2019-12-12 2021-06-17 ライオン株式会社 液体皮膚洗浄剤組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501709A (ja) * 2009-07-17 2013-01-17 レキット ベンキサー ヘルスケア インターナショナル リミテッド スキンケア組成物
US20180140541A1 (en) * 2016-11-22 2018-05-24 Truezyme Co., Ltd. Fermented composition for preventing hair loss and promoting hair growth containing natural extracts
JP2020172476A (ja) * 2019-04-12 2020-10-22 ライオン株式会社 液体皮膚洗浄剤組成物
JP2020203840A (ja) * 2019-06-14 2020-12-24 ライオン株式会社 液体皮膚洗浄剤組成物
JP2021091641A (ja) * 2019-12-12 2021-06-17 ライオン株式会社 液体皮膚洗浄剤組成物

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