WO2023165323A1 - Composition nutritionnelle, produit alimentaire de formule et utilisation - Google Patents

Composition nutritionnelle, produit alimentaire de formule et utilisation Download PDF

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WO2023165323A1
WO2023165323A1 PCT/CN2023/075719 CN2023075719W WO2023165323A1 WO 2023165323 A1 WO2023165323 A1 WO 2023165323A1 CN 2023075719 W CN2023075719 W CN 2023075719W WO 2023165323 A1 WO2023165323 A1 WO 2023165323A1
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vitamin
derived
mass
parts
zinc
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PCT/CN2023/075719
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English (en)
Chinese (zh)
Inventor
刘洋
解庆刚
崔东影
陆思宇
蒋士龙
张永久
蔡方良
冷友斌
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黑龙江飞鹤乳业有限公司
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Publication of WO2023165323A1 publication Critical patent/WO2023165323A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention generally belongs to the field of food. Specifically, the present invention relates to a nutritional composition for formula food, formula food comprising the nutritional composition, and uses of the nutritional composition or food. More specifically, the present invention relates to a nutritional composition comprising compound vitamins, compound minerals and calcium citrate, a formula food comprising the nutritional composition, especially infant formula food, preferably infant formula milk powder, Formulated milk or milk powder for children, or formulated milk or milk powder for adults, and the use of the nutritional composition or food for non-therapeutic purposes in enhancing immunity and promoting digestion and absorption.
  • Nutrients are inevitably added during its production process, and the raw materials used in formula milk powder are subject to strict supervision.
  • the vitamins and minerals in formula milk powder are crucial to the growth and immunity of fetuses, infants, and children, and usually consist of one or more combinations.
  • more than 90% of the zinc in infant formula milk powder comes from external additions, and the zinc (Zn) compounds that can be used to add infant milk powder are zinc sulfate, zinc gluconate, zinc oxide, zinc lactate, zinc citrate, zinc chloride and zinc acetate, their ratio and content are critical for optimal infant growth, as elements in different conjugated forms have different rates of digestion and absorption in the body.
  • Nutritional fortifiers such as vitamins and minerals to be added in the production process of infant formula milk powder in my country must follow the source of compounds specified in GB 14880 "National Food Safety Standards for the Use of Food Nutritional Fortifiers", but the digestion and absorption rates of different compounds There are certain differences. Therefore, in order to improve the bioavailability of vitamins and minerals in formula The utilization rate, how to choose the form of nutrient compounds close to the ingredients in breast milk and its formula composition are worthy of further study.
  • Iron is an essential micronutrient for cells. Iron is mainly involved in the transport of oxygen in the body and the transfer process of the tissue respiratory chain. Iron participates in the formation of hemoglobin, myoglobin and cytochrome, and is an important element to maintain the normal hematopoietic function of infants. In infant formula milk powder More than 95% iron comes from external additions.
  • Zinc participates in the composition of various hormones, vitamins, proteins and enzymes, and participates in the catalytic, structural and regulatory functions in the body. Zinc plays an important role in the growth and development of infants. It is an activator of enzymes in the body, which can improve the immune function of infants, maintain the integrity of the cell membrane structure, and at the same time protect the skin and vision. 90% of infant formula milk powder The above zinc is added from outside.
  • Calcium is the main component of the bones and teeth of infants. It participates in the activation of various enzymes in the body, maintains the excitability of nerves and muscles, and participates in the transmission of nerve impulses. Calcium is also involved in blood coagulation, hormone secretion, maintenance of acid-base balance and regulation of body fluids. The normal physiological function of cells is involved in the regulation of the integrity and permeability of the biofilm. More than 50% of calcium in infant formula milk powder comes from external addition.
  • Vitamin A plays a vital role in many life processes in the body and has a wide range of physiological functions, including participation in visual processes, cell proliferation and differentiation, intercellular information exchange, organ and tissue growth, reproduction, and immune system functions, which can affect infants More than 99% of vitamin A in infant formula comes from external addition
  • vitamin E The main physiological function of vitamin E is to act as a strong antioxidant to protect cell membranes from peroxidative damage; vitamin E is stored as a lipophilic compound in circulating lipoproteins, cell membranes, and adipose tissue; it reacts with free radicals and molecular oxygen, Protect polyunsaturated fatty acids and lipoproteins from peroxidation; at the same time, vitamin E also has the function of maintaining fertility, which is very important in the early stages of life and participates in the development from conception to postnatal development. More than 99% of infant formula milk powder Vitamin E is added externally.
  • vitamin B1 In addition to playing an important physiological function as a coenzyme, vitamin B1 also plays a significant role in maintaining the normal physiological functions of nerves, muscles, especially myocardium, maintaining normal appetite, gastrointestinal motility, and secretion of digestive juices. In infant formula milk powder More than 90% vitamin B1 comes from external addition.
  • retinyl acetate is mostly used for vitamin A
  • dl- ⁇ -tocopheryl acetate is mostly used for vitamin E
  • thiamine nitrate is mostly used for vitamin B1
  • ferrous sulfate and zinc are mostly used for iron Zinc sulfate is used
  • calcium carbonate is mostly used for calcium.
  • ferrous sulfate is cost-effective, its bioavailability is low and it is harmful to the stomach of infants and young children. With severe irritation, the bioavailability of zinc sulfate and calcium carbonate is low.
  • An object of the present invention is to provide a nutritional composition for formula food, which can overcome the existing formula food, especially infant formula food, such as infant formula milk powder, children's formula modified milk or milk powder, or adult formula modified milk. Or the above-mentioned defects of milk powder, enhance the body's immunity and promote digestion and absorption.
  • Another object of the present invention is to provide a formula food containing the nutritional composition, especially infant formula food, preferably infant formula milk powder, children's formula milk or milk powder, or adult formula milk or milk powder.
  • Another object of the present invention is to provide the nutritional composition or food in enhancing the body's immunity and promoting digestion and absorption (or improving the bioavailability of trace elements), especially vitamin A, vitamin E and vitamin B1 and iron, zinc and non-therapeutic purposes in the digestion and absorption of calcium.
  • a nutritional composition for formula food comprising or consisting of the following:
  • Compound vitamins which include:
  • Vitamin A part or all of which is derived from retinyl palmitate, for example all of which is derived from retinyl palmitate;
  • Vitamin E partly or wholly derived from d-alpha-tocopheryl acetate and/or d-alpha-tocopherol, e.g. wholly derived from d-alpha-tocopheryl acetate and/or d-alpha-tocopherol, e.g. whole source in d-alpha-tocopheryl acetate;
  • Vitamin B1 partly or wholly derived from thiamine hydrochloride, for example entirely derived from thiamine hydrochloride,
  • Iron a part or all of which is derived from ferrous gluconate, for example, iron is derived from ferrous gluconate or a combination of ferrous gluconate and one or more of ferrous fumarate, ferric citrate, and ferric pyrophosphate, such as all derived from ferrous gluconate, and
  • Zinc partly or wholly derived from zinc gluconate and/or zinc citrate, such as wholly derived from zinc gluconate and/or zinc citrate, such as zinc derived from zinc gluconate, zinc citrate, or zinc citrate and glucose Zinc acid,
  • the amount of vitamin A based on the active ingredient RE is 0.00008-0.007, preferably 0.0001-0.005, preferably 0.0005-0.002 parts by mass;
  • the amount of vitamin E based on the active ingredient is 0.001-0.1, preferably 0.002-0.08, preferably 0.01-0.05 parts by mass;
  • the amount of vitamin B1 in terms of active ingredients is 0.0001-0.01, preferably 0.0002-0.008, preferably 0.001-0.005 parts by mass.
  • the compound vitamin further comprises one or more of the following: vitamin D, vitamin K 1 , vitamin B 2 , vitamin B 6 , vitamin B 12 , niacin, folic acid, pantothenic acid, vitamin C, and biotin,
  • the compound vitamin further comprises vitamin D, vitamin K 1 , vitamin B 2 , vitamin B 6 , vitamin B 12 , niacin, folic acid, pantothenic acid, vitamin C, and biotin;
  • vitamin D is derived from cholecalciferol, for example all from cholecalciferol, and/or
  • part or all of the vitamin K1 is derived from phytonadiones, for example all of which are derived from phytonadiones, and/or
  • vitamin B2 is derived from riboflavin, for example entirely from riboflavin, and/or
  • vitamin B6 is derived from pyridoxine hydrochloride and/or 5'-pyridoxal phosphate, for example all is derived from pyridoxine hydrochloride and/or 5'-pyridoxal phosphate, for example all is derived from pyridoxine hydrochloride; and / or
  • vitamin B12 is derived from cyanocobalamin, for example entirely from cyanocobalamin; and/or
  • niacin is derived from niacinamide, for example all of it is derived from niacinamide; and/or
  • folic acid is derived from folic acid, such as entirely derived from folic acid;
  • pantothenic acid is derived from calcium D-pantothenate, for example all is derived from D-calcium pantothenate; and/or
  • vitamin C is derived from L-sodium ascorbate and/or L-ascorbic acid, for example all is derived from L-sodium ascorbate and/or L-ascorbic acid, for example all is derived from L-sodium ascorbate; and/or
  • biotin is derived from D-biotin, such as all is derived from D-biotin.
  • the amount of vitamin D is 0.000002-0.0002, preferably 0.000004-0.00015, preferably 0.00002-0.0001 parts by mass;
  • the amount of vitamin K1 is 0.00001-0.001, preferably 0.00005-0.0008, preferably 0.0001-0.0005 parts by mass;
  • the amount of vitamin B2 is 0.00008-0.005, preferably 0.0001-0.003, preferably 0.0005-0.002 parts by mass;
  • the amount of vitamin B6 is 0.00006-0.007, preferably 0.0001-0.005, preferably 0.0005-0.002 parts by mass;
  • the amount of vitamin B12 is 0.0000002-0.00003, preferably 0.000001-0.00001, preferably 0.000002-0.000008 parts by mass;
  • the amount of niacin is 0.0006-0.05, preferably 0.001-0.04, preferably 0.005-0.02 parts by mass;
  • the amount of folic acid is 0.00001-0.002, preferably 0.00002-0.001, preferably 0.0001-0.0005 parts by mass;
  • pantothenic acid is 0.0005-0.03, preferably 0.001-0.02, preferably 0.005-0.01 parts by mass;
  • the amount of vitamin C is 0.015-1.2, preferably 0.02-1.0, preferably 0.10-0.50 parts by mass;
  • the amount of biotin is 0.000001-0.0002, preferably 0.00001-0.0001, preferably 0.00001-0.00008 parts by mass.
  • the amount of iron element is 0.0005-0.15, preferably 0.001-0.10, preferably 0.005-0.02 parts by mass;
  • the amount of zinc element is 0.0005-0.10, preferably 0.001-0.05, preferably 0.005-0.02 parts by mass.
  • the compound minerals further include one or more of the following elements: magnesium, manganese, iodine, copper, selenium;
  • the compound minerals further include magnesium, manganese, iodine, copper, and selenium;
  • magnesium sulphate and/or magnesium gluconate are derived from magnesium sulphate and/or magnesium gluconate, for example all is derived from magnesium sulphate and/or magnesium gluconate, for example all is derived from magnesium sulphate; and/or
  • manganese is derived from manganese sulphate and/or manganese citrate and/or manganese gluconate, e.g. all is derived from manganese sulphate and/or manganese citrate and/or manganese gluconate, e.g. all is derived from magnesium sulphate; and/or or
  • iodine is derived from potassium iodate, for example entirely from potassium iodate; and/or
  • copper is derived from copper sulphate and/or copper citrate and/or copper gluconate, for example all is derived from copper sulphate and/or copper citrate and/or copper gluconate, for example all is derived from copper sulphate; and/or or
  • selenium is derived from sodium selenite, for example, all of it is derived from sodium selenite.
  • the amount of magnesium element is 0.001-0.2, preferably 0.005-0.1, preferably 0.01-0.05 parts by mass;
  • the amount of manganese element is 0.000006-0.0006, preferably 0.00001-0.0004, preferably 0.00005-0.0002 parts by mass;
  • the amount of iodine element is 0.000003-0.0015, preferably 0.00005-0.001, preferably 0.0001-0.0005 parts by mass;
  • the amount of copper element is 0.00004-0.006, preferably 0.0001-0.005, preferably 0.0005-0.002 parts by mass;
  • the amount of selenium element is 0.000001-0.0002, preferably 0.000002-0.0002, preferably 0.00001-0.0001 parts by mass.
  • each gram of multivitamin comprises:
  • Vitamin A 550-4600 ⁇ g RE, preferably 1080-3080 ⁇ g RE,
  • Vitamin E 9.0-73.0mg ⁇ -TE, preferably 18-49mg ⁇ -TE,
  • Vitamin B1 1.0-7.0mg, preferably 1.9-4.8mg
  • Vitamin D 18.0-136.0 ⁇ g, preferably 36.6-91.0 ⁇ g
  • Vitamin K1 70-670 ⁇ g, preferably 138-448 ⁇ g,
  • Vitamin B2 550-3500 ⁇ g, preferably 890-2600 ⁇ g,
  • Vitamin B6 0.45-5.0mg, preferably 0.8-3.4mg
  • Vitamin B12 1.8-16.0 ⁇ g, preferably 3.6-11.0 ⁇ g
  • Niacin 4.5-37.5mg, preferably 8.0-26.0mg
  • Folic acid 90-1100 ⁇ g, preferably 180-790 ⁇ g,
  • Pantothenic acid 3.5-25.0mg, preferably 6.0-17.6mg,
  • Vitamin C 105-900mg, preferably 185-650mg, and
  • Biotin 12.0-130.0 ⁇ g, preferably 21.0-86.8 ⁇ g;
  • Each gram of mixed minerals includes the following elements:
  • Iron 6.0-89.0mg, preferably 12.0-59.5mg
  • Zinc 3.0-75.0mg, preferably 7.0-55.2mg
  • Magnesium 10.0-120mg, preferably 19.8-79.0mg,
  • Iodine 20-900 ⁇ g, preferably 40-560 ⁇ g,
  • Copper 300-4200 ⁇ g, preferably 600-2800 ⁇ g, and
  • the amount of compound vitamins is 0.15-1.33 mass parts, preferably 0.2-1.1 mass parts;
  • the amount of the compound mineral is 0.15-1.33 parts by mass, preferably 0.2-1.1 parts by mass, relative to 1 part by mass of calcium citrate.
  • a formula food preferably infant formula food, preferably infant formula milk powder, children's formula modified milk or milk powder, adult formula modified milk or milk powder, which contains the nutrition described in any one of items 1-9 Composition, preferably the added amount of the nutritional composition in the formula food is 0.6-1.8 mass%, preferably 0.7-1.4 mass%.
  • the nutritional composition as described in any one of items 1-9 or the formula food as described in item 10 can enhance immunity and promote digestion and absorption, especially for vitamin A, vitamin E and vitamin B1 as well as iron, zinc and calcium Non-therapeutic purposes in digestion and absorption.
  • the present invention evaluates the effects of the nutritional composition containing the compound vitamins and compound minerals of the present invention on enhancing body immunity and promoting digestion and absorption.
  • the inventors have found through a large number of long-term experimental studies that by using special vitamin A (retinyl palmitate), vitamin E (d- ⁇ -acetic acid) tocopherol and/or d-alpha-tocopherol) and vitamin B1 (thiamine hydrochloride) and iron (ferrous gluconate), zinc (zinc citrate and/or zinc gluconate) and calcium (calcium citrate), Compared with vitamin A (retinyl acetate), vitamin E (dl- ⁇ -tocopheryl acetate) and vitamin B1 (thiamine nitrate) and iron (sulfuric acid) commonly used in existing formula foods, especially infant formula foods ferrous), zinc (zinc sulfate) and calcium (calcium carbonate), the present invention has the functions of obviously enhancing the immunity of the body, reducing the risk of various diseases, and promoting digestion and
  • infant refers to the population of 0 to 6 months of age.
  • infant refers to the population of 6 to 12 months of age.
  • young child refers to the population of 12 to 36 months of age.
  • infant refers to the population of 0-36 months of age.
  • children refers to people aged 4 to 18 years.
  • adult refers to people over the age of 18, including pregnant women and middle-aged and elderly people.
  • infant formula encompasses infant formula, follow-on formula and toddler formula.
  • infant formula is used as a breast milk substitute from the birth of a baby
  • formula for older infants is used as a breast milk substitute from 6-12 months after birth
  • formula for young children is used as a substitute for breast milk from 12-36 months after birth.
  • Breastmilk substitutes are used as a substitute for breast milk from 12-36 months after birth.
  • infant formula refers to milk and milk protein products or soybeans and soybean protein products as the main raw materials, adding appropriate amount of vitamins, minerals and/or other ingredients, and produced and processed by only physical methods in liquid or powder form product. It is suitable for normal infants, and its energy and nutrients can meet the normal nutritional needs of infants aged 0-6 months.
  • following-up formula refers to milk and milk protein products or soybeans and soybean protein products as the main raw materials, adding appropriate amount of vitamins, minerals and/or other ingredients, produced only by physical methods Liquid or powder products made by production and processing. It is suitable for older babies, and its energy and nutrients can meet part of the nutritional needs of normal older babies aged 6-12 months.
  • infant formula food refers to milk and milk protein products or soybeans and soybean protein products as the main raw materials, adding appropriate amount of vitamins, minerals and/or other ingredients, and produced and processed by only physical methods in liquid or powder form product. Suitable for young children, its energy and nutrients can meet part of the nutritional needs of normal children aged 12'-36 months.
  • Children's Formula Modified Milk or Milk Powder refers to milk and milk protein products as the main raw materials, adding appropriate amount of vitamins, minerals and/or other ingredients, which are produced and processed by physical methods and are suitable for children. or powdered products.
  • adult formula modified milk or milk powder refers to a liquid product suitable for adults that is produced and processed by physical methods, with milk and milk protein products as the main raw materials, adding appropriate amounts of vitamins, minerals and/or other ingredients. or powdered products.
  • breast milk is to be understood as mother's breast milk or colostrum.
  • exclusive breastfed infant or young child has its usual meaning and refers to an infant whose nutritional and/or energy is derived substantially from human breast milk.
  • infant/older infant/toddler mainly fed with infant formula has the usual meaning, referring to infant formula, older Infant milk or growing-up milk for infants or young children.
  • the term “mainly” means at least 50%, such as at least 75%, of those nutrients and/or energy. Unless otherwise specified, the percentages (%) in this specification are all percentages by weight (% by weight).
  • references to "A and/or B”, when used in conjunction with an open-ended word such as “comprising”, may, in one embodiment, refer to only A (optionally including in addition to B In another embodiment, it may refer to only B (optionally including components other than A); in yet another embodiment, it may refer to A and B (optionally including other components) and so on.
  • the present invention provides a nutritional composition comprising or consisting of:
  • Compound vitamins which include:
  • Vitamin A part or all of which is derived from retinyl palmitate
  • Vitamin E derived in part or in whole from d-alpha-tocopheryl acetate and/or d-alpha-tocopherol;
  • Vitamin B 1 part or all of which is derived from thiamine hydrochloride
  • Iron some or all of which is derived from ferrous gluconate
  • Zinc part or all of which is derived from zinc gluconate and/or zinc citrate
  • the nutritional composition of the present invention has (but is not limited to) the following functions: promote the perfection of the body's immune system and enhance the body's immunity , reduce the risk of various diseases, etc., and at the same time promote the digestion and absorption of nutritional components:
  • the compound vitamins include vitamin A, vitamin E and vitamin B 1 .
  • vitamin A is derived from retinyl palmitate, for example, all vitamin A is derived from retinyl palmitate.
  • the amount of vitamin A in terms of active ingredients can be 0.00008-0.007 in mass parts (i.e., when calcium citrate is 1 gram, the amount of vitamin A Can be 80-7000 ⁇ g RE), preferably 0.0001-0.005, preferably 0.0005-0.002, for example can be 0.00008, 0.00009, 0.0001, 0.0002, 0.0003, 0.0004, 0.0005, 0.0006, 0.0007, 0.0008, 0.00 09, 0.0010, 0.0015, 0.0020, 0.0025 , 0.0030, 0.0035, 0.0040, 0.0045, 0.0050, 0.0055, 0.0060, 0.0065, 0.0070, or a range defined by any two thereof and any values and subranges subsumed within that range.
  • vitamin E is derived from d-alpha-tocopheryl acetate and/or d-alpha-tocopherol, for example all is derived from d-alpha-tocopheryl acetate and/or d-alpha-tocopherol, for example all is derived from d-alpha-tocopheryl acetate.
  • the amount of vitamin E in terms of active ingredients can be 0.001-0.1, preferably 0.002-0.08, preferably 0.01-0.05, such as 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.010, 0.015, 0.020, 0.025, 0.030, 0.035, 0.040, 0.045, 0.050, 0.055, 0.060, 0.065, 0 .070, 0.075, 0.080, 0.085, 0.090, 0.095, 0.10, or ranges bounded by any two thereof and any values and subranges subsumed within that range.
  • vitamin B1 is derived from thiamine hydrochloride, for example, all of it is derived from thiamine hydrochloride.
  • the amount of vitamin B1 in terms of active ingredients can be 0.0001-0.01, preferably 0.0002-0.008, preferably 0.001-0.005, such as 0.0001, 0.00015, 0.0002, 0.0003, 0.0004, 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.0010, 0.0015, 0.0020, 0.0025, 0.0030, 0.0035, 0.0040, 0.0045, 0.0050, 0.0055, 0. 0060, 0.0065, 0.0070, 0.0075, 0.0080, 0.0085, 0.0090, 0.0095, 0.010, or a range bounded by any two thereof, and any values and subranges subsumed within that range.
  • the present inventors have found that when the amount of defined vitamin A, vitamin E and vitamin B1 is within the above range, the nutritional composition of the present invention can better promote the perfection of the body's immune system, enhance the body's immunity, and reduce the risk of various diseases. risks, etc., while promoting the digestion and absorption of nutritional components.
  • the multivitamins can optionally further comprise vitamin A (such as retinyl acetate), vitamin E (dl- ⁇ -tocopheryl acetate) and vitamin B1 (that is, thiamine nitrate) from other sources commonly used in the art. white).
  • vitamin A i.e. retinyl palmitate
  • vitamin E i.e. d-alpha-tocopheryl acetate and/or d-alpha-tocopherol
  • vitamin B1 i.e. thiamine hydrochloride
  • the multivitamins can optionally further comprise vitamin A (such as retinyl acetate), vitamin E (dl- ⁇ -tocopheryl acetate) and vitamin B1 (that is, thiamine nitrate) from other sources commonly used in the art. white).
  • the compound vitamin may further include one or more of the following: vitamin D, vitamin K 1 , vitamin B 2 , vitamin B 6 , vitamin B 12 , niacin, folic acid, pantothenic acid, vitamin C, and biotin.
  • the compound vitamin in addition to the defined vitamin A, vitamin E and vitamin B1 , further comprises vitamin D, vitamin K1 , vitamin B2 , vitamin B6 , vitamin B12 , niacin, folic acid, pantothenic acid, vitamin C, and biotin.
  • the multivitamins may further include vitamin D.
  • part or all of the vitamin D is derived from cholecalciferol, for example all of it is derived from cholecalciferol.
  • the amount of vitamin D in terms of active ingredient may be 0.000002-0.0002, preferably 0.000004-0.00015, preferably 0.000004-0.00015, preferably 0.00002-0.0001, such as 0.000002, 0.000003, 0.000004, 0.000005, 0.000006, 0.000007, 0.000008, 0.000009, 0.000010, 0.000015, 0.000020, 0.00 0025, 0.000030, 0.000035, 0.000040, 0.000045, 0.000050, 0.000055, 0.000060, 0.000065, 0.000070, 0.000075 , 0.000080, 0.000085, 0.000090, 0.000095, 0.00010, 0.00011, 0.00012, 0.00013, 0.00014, 0.00015, 0.00016, 0.00017, 0.00018, 0.00019, 0.00 020, or the range defined by any two of them and any value and sub- scope.
  • the compound vitamin may further include vitamin K 1 .
  • part or all of vitamin K1 is derived from phytonadione, for example all is derived from phytonadione.
  • the amount of vitamin K 1 in terms of active ingredient may be 0.00001-0.001 in parts by mass, preferably 0.00005-0.0008, preferably 0.0001-0.0005, for example may be 0.00001, relative to 1 part by mass of calcium citrate ,0.00002,0.00003,0.00004,0.00005,0.00006,0.00007,0.00008,0.00009,0.00010,0.00015,0.00020,0.00025,0.00030,0.00035,0.00040, 0.00045, 0.00050, 0.00055, 0.00060, 0.00065, 0.00070, 0.00075, 0.00080, 0.00085, 0.00090 , 0.00095, 0.0010, or ranges defined by any two thereof and any values and subranges subsumed within that range.
  • the compound vitamin may further include vitamin B 2 .
  • vitamin B2 is derived from riboflavin, for example all of it is derived from riboflavin.
  • the amount of vitamin B2 in terms of active ingredient may be 0.00008-0.005, preferably 0.0001-0.003, preferably 0.0005-0.002, for example may be 0.00008, relative to 1 mass part of calcium citrate ,0.00009,0.0001,0.0002,0.0003,0.0004,0.0005,0.0006,0.0007,0.0008,0.0009,0.0010,0.0015,0.0020,0.0025,0.0030,0.0035,0.0040, 0.0045, 0.0050, or a range defined by any two thereof and including Any value within that range and subranges.
  • the compound vitamin may further include vitamin B 6 .
  • part or all of vitamin B6 is derived from pyridoxine hydrochloride and/or pyridoxal 5'-phosphate, for example all is derived from pyridoxine hydrochloride and/or pyridoxal 5'-phosphate, for example all is derived from pyridoxine hydrochloride Pyridoxine.
  • the amount of vitamin B6 in terms of active ingredient may be 0.00006-0.007, preferably 0.0001-0.005, preferably 0.0005-0.002, for example may be 0.00006, relative to 1 mass part of calcium citrate , 0.00007, 0.00008, 0.00009, 0.0001, 0.0002, 0.0003, 0.0004, 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.0010, 0.0015, 0.0020, 0.0025, 0.003 0, 0.0035, 0.0040, 0.0045, 0.0050, 0.0055, 0.0060, 0.0065, 0.0070 , or a range defined by any two thereof and any values and subranges subsumed within that range.
  • the compound vitamins may further include vitamin B 12 .
  • part or all of the vitamin B12 is derived from cyanocobalamin, for example entirely derived from cyanocobalamin.
  • the amount of vitamin B 12 in terms of active ingredient may be 0.0000002-0.00003 parts by mass, preferably 0.000001-0.00001, preferably 0.000002-0.000008, for example may be 0.0000002, relative to 1 part by mass of calcium citrate , 0.0000003, 0.0000004, 0.0000005, 0.0000006, 0.0000007, 0.0000008, 0.0000009, 0.0000010, 0.0000015, 0.0000020, 0.0000025, 0.0000030, 0.0000035, 0.0000040, 0.0000045, 0.0000050, 0.0000055, 0.0000060, 0.0000065, 0.0000070, 0.0000075, 0.0000080, 0.0000085, 0.0000090, 0.0 000095 , 0.000010, 0.000011, 0.000012, 0.000013, 0.000014, 0.000015, 0.000016, 0.000017, 0.000018, 0.000019, 0.000020, 0.000025, 0.000030, or Any two defined ranges and
  • the multivitamins may further include niacin.
  • part or all of the niacin is derived from niacinamide, for example all of it is derived from niacinamide.
  • the amount of niacin in terms of active ingredient may be 0.0006-0.05, preferably 0.001-0.04, preferably 0.005-0.02, for example may be 0.0006, 0.0007, 0.0008, 0.0009, 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.010, 0.015, 0.020, 0.025, 0.030, 0.035, 0.040, 0.04 5, 0.050, or limited by any two of them range and any values and subranges subsumed within that range.
  • the multivitamin may further comprise folic acid.
  • some or all of the folic acid is derived from folic acid (pteroylglutamic acid), for example entirely derived from acid (pteroylglutamic acid).
  • the amount of folic acid in terms of active ingredient may be 0.00001-0.002, preferably 0.00002-0.001, preferably 0.0001-0.0005, for example may be 0.00001, 0.00002 in parts by mass relative to 1 part by mass of calcium citrate ,0.00003,0.00004,0.00005,0.00006,0.00007,0.00008,0.00009,0.00010,0.00015,0.00020,0.00025,0.00030,0.00035,0.00040,0.00045, 0.00050, 0.00055, 0.00060, 0.00065, 0.00070, 0.00075, 0.00080, 0.00085, 0.00090, 0.00095 , 0.0010, 0.0011, 0.0012, 0.0013, 0.0014, 0.0015, 0.0016, 0.0017, 0.0018, 0.0019, 0.0020, or ranges defined by any two thereof and any values and subranges subsumed within that range.
  • the multivitamins may further include pantothenic acid.
  • part or all of the pantothenic acid is derived from calcium D-pantothenate, for example, all of it is derived from calcium D-pantothenate.
  • the amount of pantothenic acid in terms of active ingredient may be 0.0005-0.03, preferably 0.001-0.02, preferably 0.005-0.01 in parts by mass relative to 1 part by mass of calcium citrate, for example may be 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.0010, 0.0015, 0.0020, 0.0025, 0.0030, 0.0035, 0.0040, 0.0045, 0.0050, 0.0055, 0.0060, 0.0065, 0.
  • the multivitamins may further include vitamin C.
  • part or all of vitamin C is derived from L-sodium ascorbate and/or L-ascorbic acid, for example all is derived from L-sodium ascorbate and/or L-ascorbic acid, for example all is derived from L-sodium ascorbate.
  • the amount of vitamin C in terms of active ingredient may be 0.015-1.2, preferably 0.02-1.0, preferably 0.10-0.50, for example may be 0.015, relative to 1 mass part of calcium citrate , 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.15, 0.20, 0.25, 0.30, 0.35, 0.40, 0.45, 0.50, 0.55, 0.60, 0.65, 0.70, 0.75, 0.80, 0.85, 0.90 , 0.95, 1.0, 1.10, 1.15, 1.20, or a range defined by any two thereof and any values and subranges subsumed within that range.
  • the multivitamins may further contain biotin.
  • part or all of the biotin is derived from D-biotin, such as all is derived from D-biotin.
  • the amount of biotin in terms of active ingredient may be 0.000001-0.0002, preferably 0.00001-0.0001, preferably 0.00001-0.00008, for example may be 0.000001, 0.0000015, 0.000002, 0.000003, 0.000004, 0.000005, 0.000006, 0.000007, 0.000008, 0.000009, 0.000010, 0.000015, 0.000020, 0.000025, 0.0 00030, 0.000035, 0.000040, 0.000045, 0.000050, 0.000055, 0.000060, 0.000065, 0.000070, 0.000075, 0.000080, 0.000085, 0.000090, 0.000095, 0.00010, 0.00011, 0.00012, 0.00013, 0.00014, 0.00015, 0.00016, 0.00017, 0.00018, 0.00019, 0.00020, or a range defined by any two thereof and encompassed within such range Arbitrary values and subranges of .
  • the compound vitamin may further contain other nutritional components, such as taurine, L-carnitine, inositol, choline chloride and the like.
  • the multivitamins may further include taurine.
  • the amount of taurine in terms of active ingredient may be 0.01-1.0, preferably 0.05-0.2 by mass, for example may be 0.01, 0.02, 0.03, 0.04, relative to 1 part by mass of calcium citrate 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.15, 0.25, 0.30, 0.35, 0.40, 0.50, 0.55, 0.65, 0.70, 0.80, 0.90, 0.95, 1.0, or or, or or A range defined by any two thereof and any values and subranges subsumed within that range.
  • the compound vitamin further includes auxiliary materials.
  • the auxiliary material can be lactose or maltodextrin or other food raw materials that meet regulatory requirements.
  • the excipients are present in an amount to aid in the effective dispersion of the vitamin components mentioned.
  • the amount of the excipient contained in the compound vitamin can be 0.01-10 mass parts, for example, it can be 0.01, 0.02, 0.03, 0.04, 0.05, 0.06 0.07, 0.08, 0.10, 0.10, 0.15, 0.20, 0.0.30, 0.35, 0.40, 0.50, 0.55, 0.60, 0.70, 0.75, 0.85, 0.95, 1.0, 1.0, 2.0, 2.5, 2.5 , 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0, or the range defined by any two thereof and any value and sub- scope.
  • the compound vitamins include the following:
  • Vitamin A part or all of which is derived from retinyl palmitate, preferably all of which is derived from retinyl palmitate;
  • Vitamin E part or all of which is derived from d-alpha-tocopheryl acetate and/or d-alpha-tocopherol, preferably all of it is derived from d-alpha-tocopheryl acetate and/or d-alpha-tocopherol;
  • Vitamin B 1 part or all of which is derived from thiamine hydrochloride, preferably all of which is derived from thiamine hydrochloride;
  • Vitamin D preferably derived from cholecalciferol
  • Vitamin K 1 preferably derived from phytonadione
  • Vitamin B2 preferably derived from riboflavin
  • Vitamin B6 preferably derived from pyridoxine hydrochloride and/or pyridoxal 5'-phosphate
  • Vitamin B 12 preferably derived from cyanocobalamin
  • Niacin preferably derived from niacinamide
  • Folic acid preferably derived from folic acid (pteroylglutamic acid);
  • Pantothenic acid preferably derived from calcium D-pantothenate
  • Vitamin C preferably derived from sodium L-ascorbate and/or L-ascorbic acid
  • biotin preferably derived from D-biotin
  • taurine is added.
  • the compound vitamins include the following:
  • Vitamin A all derived from retinyl palmitate
  • Vitamin E all derived from d-alpha-tocopheryl acetate and/or d-alpha-tocopherol;
  • Vitamin B 1 all derived from thiamine hydrochloride
  • Vitamin D which is derived from cholecalciferol
  • Vitamin K 1 derived from phytonadione
  • Vitamin B2 which is derived from riboflavin
  • Vitamin B6 derived from pyridoxine hydrochloride and/or pyridoxal 5'-phosphate
  • Vitamin B 12 derived from cyanocobalamin
  • Niacin which is derived from niacinamide
  • Folic acid which is derived from folic acid (pteroylglutamate);
  • Pantothenic acid which is derived from calcium D-pantothenate
  • Vitamin C derived from sodium L-ascorbate and/or L-ascorbic acid
  • Biotin derived from D-biotin
  • taurine is added.
  • each gram of compound vitamin in the nutritional composition includes the following ingredients (calculated as active ingredients):
  • Vitamin A 550-4600 ⁇ g RE, preferably 1080-3080 ⁇ g RE, e.g. 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1050, 1100, 1150, 1200, 1250, 1300, 1350, 1400 , 1450, 1500, 1550, 1600, 1650, 1700, 1750, 1800, 1850, 1900, 1950, 2000, 2050, 2100, 2150, 2200, 2250, 2300, 2350, 2400, 2450, 2500, 2550, 2600, 2650 ,2700,2750,2800,2850,2900,2950,3000,3050,3100,3150,3200,3250,3300,3350,3400,3450,3500,3550,3600,3650,3700,3750,3800,3850, 3900 , 3950, 4000, 4050, 4100, 4150, 4200, 4250, 4300, 4350, 4400,
  • Vitamin E 9.0-73.0 mg alpha-TE, preferably 18-49 mg alpha-TE, eg 9.0, 10.0, 11.0, 12.0, 13.0, 14.0, 15.0, 16.0, 17.0, 18.0, 19.0, 20.0, 21.0, 22.0, 23.0, 24.0, 25.0, 26.0, 27.0, 28.0, 29.0, 30.0, 31.0, 32.0, 33.0, 34.0, 35.0, 36.0, 37.0, 38.0, 39.0, 40.0, 41.0, 42.0, 43.0, 44.0, 45.0, 46.0, 47.0, 4 8.0, 49.0, 50.0, 51.0, 52.0, 53.0, 54.0, 55.0, 56.0, 57.0, 58.0, 59.0, 60.0, 61.0, 62.0, 63.0, 64.0, 65.0, 66.0, 67.0, 68.0, 69.0, 70.0, 71.0, 72.0, 7 3.0mg ⁇ -TE, or a range defined by any two thereof, and
  • Vitamin B1 1.0-7.0 mg, preferably 1.9-4.8 mg, eg 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 7.0 mg or ranges defined by any two thereof and encompassed within any value within that range and subranges;
  • Vitamin D 18.0-136.0 ⁇ g, preferably 36.6-91.0 ⁇ g, eg 18.0, 18.5, 19.0, 19.5, 20.0, 20.5, 21.0, 21.5, 22.0, 22.5, 23.0, 23.5, 24.0, 24.5, 25.0, 25.5, 26.0, 26.5 ,27.0,27.5,28.0,28.5,29.0,29.5,30.0,30.5,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0, 47.0 , 48.0, 49.0, 50.0, 51.0, 52.0, 53.0, 54.0, 55.0, 56.0, 57.0, 58.0, 59.0, 60.0, 61.0, 62.0, 63.0, 64.0, 65.0, 66.0, 67.0, 68.0, 69.0, 70.0, 71.0, 72.0, 73.0, 74.0, 75.0, 76.0,
  • Vitamin K1 70-670 ⁇ g, preferably 138-448 ⁇ g, for example 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200, 205, 210, 215, 220, 225, 230, 235, 240, 245, 250, 255, 260, 265, 270, 275, 280, 285, 290, 295, 300, 305, 310, 315, 320, 325, 330, 335, 340, 345, 350, 355, 360, 365, 370, 375, 380, 385, 390, 395, 400, 405, 410, 415, 420, 425, 430, 435, 440, 445, 450, 455, 460, 465, 470, 475, 480, 485, 490, 495, 500, 50,
  • Vitamin B2 550-3500 ⁇ g, preferably 890-2600 ⁇ g, for example 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1050, 1100, 1150, 1200, 1250, 1300, 1350, 1400, 1450, 1500, 1550, 1600, 1650, 1700, 1750, 1800, 1850, 1900, 1950, 2000, 2050, 2100, 2150, 2200, 2250, 2300, 2350, 2400, 2450, 2500, 2550, 2600, 2 650, 2700, 2750, 2800, 2850, 2900, 2950, 3000, 3050, 3100, 3150, 3200, 3250, 3300, 3350, 3400, 3450, 3500 ⁇ g, or the range defined by any two thereof and included within the range Arbitrary values and subranges;
  • Vitamin B6 0.45-5.0 mg, preferably 0.8-3.4 mg, eg 0.45, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5.0 mg, or a range defined by any two thereof and any values and subranges subsumed within that range;
  • Vitamin B12 1.8-16.0 ⁇ g, preferably 3.6-11.0 ⁇ g, eg 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 7.0, 7.1, 7.2, 7.3, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 8.0, 8.1, 8.2, 8.3, 8.4, 8.5, 8.6, 8.7, 8.8, 8.9, 9.0, 9.1, 9.2, 9.3, 9.4, 9.5, 9.6, 9.7, 9.8, 9.9, 1
  • Niacin 4.5-37.5 mg, preferably 8.0-26.0 mg, eg 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0, 10.5, 11.0, 11.5, 12.0, 12.5, 13.0 ,13.5,14.0,14.5,15.0,15.5,16.0,16.5,17.0,17.5,18.0,18.5,19.0,19.5,20.0,20.5,21.0,21.5,22.0,22.5,23.0,23.5,24.0,24.5,25.0, 25.5 , 26.0, 26.5, 27.0, 27.5, 28.0, 28.5, 29.0, 29.5, 30.0, 30.5, 31.0, 31.5, 32.0, 32.5, 33.0, 33.5, 34.0, 34.5, 35.0, 35.5, 36.0, 36.5, 37.0, 37.5mg , or a range defined by any two thereof and any values and subranges subsumed within that range;
  • Folic acid 90-1100 ⁇ g, preferably 180-790 ⁇ g, eg 90, 95, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200, 205, 210, 215, 220, 225, 230, 235, 240, 245, 250, 255, 260, 265, 270, 275, 280, 285, 290, 295, 300, 305, 310, 315, 320, 325, 330, 335, 340, 345, 350, 355, 360, 365, 370, 375, 380, 385, 390, 395, 400, 405, 410, 415, 420, 425, 430, 435, 440, 445, 450, 455, 460, 465, 470, 475, 480, 485, 490, 495, 500, 505, 510, 515, 520
  • Pantothenic acid 3.5-25.0 mg, preferably 6.0-17.6 mg, eg 3.5, 3.6, 3.7, 3.8, 3.9, 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 7.0, 7.1, 7.2, 7.3, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 8.0, 8.1, 8.2, 8.3, 8.4, 8.5, 8.6, 8.7, 8.8, 8.9, 9.0, 9.1, 9.2, 9.3, 9.4, 9.5, 9.6, 9.7, 9.8, 9.9, 10.0, 10.1, 10.2, 10.3, 10.4, 10.5, 10.6, 10.7, 10.8, 10.9, 11.0, 11.1, 11.2, 11.3, 11.4, 11.5, 11.6, 11.7, 11.8, 11.9, 12.0, 12.1, 12.
  • Vitamin C 105-900 mg, preferably 185-650 mg, eg 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195 , 200, 205, 210, 215, 220, 225, 230, 235, 240, 245, 250, 255, 260, 265, 270, 275, 280, 285, 290, 295, 300, 305, 310, 315, 320, 325, 330, 335, 340, 345, 350, 355, 360, 365, 370, 375, 380, 385, 390, 395, 400, 405, 410, 415, 420, 425, 430, 435, 440, 445, 450, 455, 460, 465, 470, 475, 480, 485, 490, 495, 500, 505, 510, 515, 520, 525, 530, 5
  • Biotin 12.0-130.0 ⁇ g, preferably 21.0-86.8 ⁇ g, such as 12.0, 13.0, 14.0, 15.0, 16.0, 17.0, 17.5, 18.0, 19.0, 20.0, 21.0, 22.0, 23.0, 24.0, 25.0, 26.0, 27.0, 28.0 ,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0, 53.0 ,54.0,55.0,56.0,57.0,58.0,59.0,60.0,61.0,62.0,63.0,64.0,65.0,66.0,67.0,68.0,69.0,70.0,71.0,72.0,73.0,74.0,75.0,76.0,77.0, 78.0 .
  • each gram of compound vitamin composition in the nutritional composition comprises the following components: vitamin A: 1080-3080 ⁇ g RE, vitamin E: 18-49 mg ⁇ -TE, vitamin B1 : 1.9-4.8 mg, Vitamin D: 36.6-91.0 ⁇ g, Vitamin K1 : 138-448 ⁇ g, Vitamin B2 : 890-2600 ⁇ g, Vitamin B6 : 0.8-3.4mg, Vitamin B12 : 3.6-11.0 ⁇ g, Niacin: 8.0-26.0 mg, folic acid: 180-790 ⁇ g, pantothenic acid: 6.0-17.6mg, vitamin C: 185-650mg, biotin: 21.0-86.8 ⁇ g.
  • the nutritional composition of the present invention further includes one of vitamin D, vitamin K 1 , vitamin B 2 , vitamin B 6 , vitamin B 12 , niacin, folic acid, pantothenic acid, vitamin C, and biotin or more, especially all of them, it can more balance the nutrition needed by the human body, and better promote the improvement of the body's immune system, enhance the body's immunity, reduce the risk of various diseases, etc., and at the same time promote the nutrition components Digestion and absorption.
  • the mineral complex contains iron and zinc.
  • iron is derived from ferrous gluconate, for example, iron is derived from ferrous gluconate or a combination of ferrous gluconate and one or more of ferrous fumarate, ferric citrate, and ferric pyrophosphate, such as All derived from ferrous gluconate.
  • the amount of iron element can be 0.0005-0.15, preferably 0.001-0.10, preferably 0.005-0.02, for example, can be 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.010, 0.015, 0.020, 0.025, 0.030, 0.035, 0.040, 0.045, 0.050, 0.055, 0.060, 0 .065, 0.070, 0.075, 0.080, 0.085, Ranges defined by 0.090, 0.095, 0.10, 0.11, 0.12, 0.13, 0.14, 0.15, or any two thereof and any values and subranges subsumed within that range.
  • zinc is derived from zinc gluconate and/or zinc citrate, for example all is derived from zinc gluconate and/or zinc citrate, such as zinc is derived from zinc gluconate, zinc citrate, or zinc citrate and gluconic acid Zinc, such as zinc derived from zinc citrate, or zinc citrate and zinc gluconate.
  • the compound minerals include zinc citrate and zinc gluconate, wherein the mass ratio of zinc derived from zinc citrate to zinc derived from zinc gluconate can be (0.1-10) :1, preferably (0.5-2):1, such as 0.1:1, 0.2:1, 0.25:1, 0.3:1, 0.4:1, 0.5:1, 0.6:1, 0.7:1, 0.8:1 , 0.9:1, 1.0:1, 2.0:1, 2.5:1, 3.0:1, 4.0:1, 5.0:1, 6.0:1, 7.0:1, 8.0:1, 9.0:1, 10.0:1, or A range defined by any two thereof and any values and subranges subsumed within that range.
  • the amount of zinc element can be 0.0005-0.10 in terms of mass parts, preferably 0.001-0.05, preferably 0.005-0.02, for example can be 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.0010,0.0015,0.0020,0.0025,0.0030,0.0035,0.0040,0.0045,0.0050,0.0055,0.0060,0.0065,0.0070,0.0075,0.0080,0.0085,0.0090,0.
  • the inventors found that when a part or all of the iron is especially all derived from ferrous gluconate, a part or all of the zinc is especially all derived from zinc gluconate and/or zinc citrate, and the amount of iron and zinc elements is within the above-mentioned Within the range, the nutritional composition of the present invention can better improve the immune system of the body, enhance the immunity of the body, reduce the risk of various diseases, etc., and at the same time promote the digestion and absorption of nutritional components.
  • the present inventors have also found that in the nutritional composition of the present invention, when zinc citrate is used to partially or completely replace zinc gluconate, for example, it can enhance the body's immunity, reduce the risk of various diseases, and at the same time promote digestion. Better results can be achieved in terms of absorption. Furthermore, the inventors also found that when zinc citrate and zinc gluconate are used in combination, there is a synergistic effect between the two, and the effect can be improved synergistically.
  • the complex minerals may optionally further comprise iron from other sources commonly used in the art (such as ferrous sulfate) and zinc (such as zinc sulfate).
  • the compound minerals may further include one or more of the following elements: magnesium, manganese, iodine, copper, selenium.
  • the mineral complex may further include magnesium, manganese, iodine, copper, and selenium.
  • the mineral complex may further comprise magnesium.
  • part or all of the magnesium is derived from magnesium sulphate and/or magnesium gluconate, for example all is derived from magnesium sulphate and/or magnesium gluconate, for example all is derived from magnesium sulphate.
  • the amount of magnesium element can be 0.001-0.2, preferably 0.005-0.1, preferably 0.01-0.05, such as 0.001, 0.0015, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.010, 0.015, 0.020, 0.025, 0.030, 0.035, 0.040, 0.045, 0.050, 0.055, 0.060, 0.065, 0.070, 0.075, 0.080, 0.085, 0.090, 0.095, 0.10, 0.11, 0.12, 0.13, 0.14, 0.15, 0 .16, 0.17, 0.18, 0.19, 0.20, or a range defined by any two thereof, and any values and subranges subsumed within that range.
  • the complex minerals may further comprise manganese.
  • part or all of the manganese is derived from manganese sulphate and/or manganese citrate and/or manganese gluconate, e.g. all from manganese sulphate and/or manganese citrate and/or manganese gluconate, e.g. all from magnesium sulphate .
  • the amount of manganese element can be 0.000006-0.0006, preferably 0.00001-0.0004, preferably 0.00005-0.0002, such as 0.000006, 0.000007, 0.000008, 0.000009, 0.00001, 0.00002, 0.00003, 0.00004, 0.00005, 0.00006, 0.00007, 0.00008, 0.00009, 0.00010, 0.00015, 0.00020, 0.00025, 0.00030, 0.00035, 0.00040, 0.00045, 0.00050, 0.00055, 0.00060, or any two of them range and any values and subranges subsumed within that range.
  • the complex minerals may further comprise iodine.
  • part or all of iodine is derived from potassium iodate, for example all is derived from potassium iodate.
  • the amount of iodine element can be 0.000003-0.0015, preferably 0.00005-0.001, preferably 0.0001-0.0005, such as 0.000003, 0.000004, 0.000005, 0.000006, 0.000007, 0.000008, 0.000009, 0.000010, 0.000015, 0.000020, 0.000025, 0.000030, 0.000035, 0.000040, 0.000045, 0.000050, 0.00 0055, 0.000060, 0.000065, 0.000070, 0.000075, 0.000080, 0.000085, 0.000090, 0.000095, 0.00010, 0.00015, 0.00020, 0.00025, 0.00030, 0.00035, 0.00040, 0.00045, 0.00050, 0.00055, 0.00060, 0.00065, 0.00070, 0.00075, 0.00080, 0.00085, 0.00090, 0.00095, 0 .0010, 0.0011, 0.0012, 0.00
  • the complex minerals may further comprise copper.
  • part or all of the copper is derived from copper sulfate and/or copper citrate and/or copper gluconate, for example entirely derived from copper sulfate and/or copper citrate and/or copper gluconate, for example entirely derived from copper sulfate .
  • the amount of copper element can be 0.00004-0.006, preferably 0.0001-0.005, preferably 0.0005-0.002, such as 0.00004, 0.00005, 0.00006, 0.00007, 0.00008, 0.00009, 0.00010, 0.00015, 0.00020, 0.00025, 0.00030, 0.00035, 0.00040, 0.00045, 0.00050, 0.00055, 0.00060, 0.00065, 0 .00070, 0.00075, 0.00080, 0.00085, 0.00090, 0.00095, 0.0010, 0.0015, 0.0020, 0.0025, 0.0030, 0.0035, 0.0040, 0.0045, 0.0050, 0.0055, 0.0060, or a range defined by any two thereof and any values and subranges subsumed within that range.
  • the complex minerals may further comprise selenium.
  • part or all of the selenium is derived from sodium selenite, for example all of it is derived from sodium selenite.
  • the amount of selenium in terms of parts by mass can be 0.000001-0.0002, preferably 0.000002-0.0002, preferably 0.00001-0.0001, for example can be 0.000001, 0.000002, 0.000003, 0.000004, 0.000005, 0.000006, 0.000007, 0.000008, 0.000009, 0.000010, 0.000015, 0.000020, 0.000025, 0.000030, 0.000035, 0.000040, 0.00 0045, 0.000050, 0.000055, 0.000060, 0.000065, 0.000070, 0.000075, 0.000080, 0.000085, 0.000090, 0.000095, 0.00010, Ranges defined by 0.00011, 0.00012, 0.00013, 0.00014, 0.00015, 0.00016, 0.00017, 0.00018, 0.00019, 0.00020, or any two thereof and any values and subranges subsumed within that range.
  • the compound minerals may optionally further contain other mineral components, such as calcium carbonate, sodium citrate, potassium chloride, calcium hydrogen phosphate and the like.
  • the compound minerals further include auxiliary materials.
  • the auxiliary material can be lactose or maltodextrin or other food raw materials that meet regulatory requirements.
  • adjuncts are present in amounts to aid in the effective dispersion of the mineral components mentioned.
  • the amount of the auxiliary material contained in the compound mineral may be 0.01-10 mass parts, such as 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.15, 0.20, 0.25, 0.30, 0.35, 0.40, 0.45, 0.50, 0.55, 0.60, 0.65, 0.70, 0.75, 0.80, 0.85, 0.90, 0.95, 1.0, 1.5, 2.0 , 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0, or the range defined by any two thereof and any value included in the range and subranges.
  • the compound minerals include the following:
  • ferrous gluconate Iron, part or all of which is derived from ferrous gluconate, preferably derived from ferrous gluconate or a combination of ferrous gluconate and one or more of ferrous fumarate, ferric citrate, and ferric pyrophosphate , preferably all of which are derived from ferrous gluconate;
  • Zinc part or all of which is derived from zinc citrate and/or zinc gluconate, preferably entirely derived from zinc citrate and/or zinc gluconate;
  • Magnesium preferably derived from magnesium sulfate and/or magnesium gluconate
  • Manganese preferably derived from manganese sulfate and/or manganese citrate and/or manganese gluconate;
  • Iodine preferably derived from potassium iodate
  • Copper preferably derived from copper sulfate and/or copper citrate and/or copper gluconate;
  • the compound minerals include the following:
  • Zinc all derived from zinc citrate and/or zinc gluconate
  • Magnesium derived from magnesium sulfate and/or magnesium gluconate
  • Manganese derived from manganese sulfate and/or manganese citrate and/or manganese gluconate;
  • Iodine which is derived from potassium iodate
  • Copper derived from copper sulfate and/or copper citrate and/or copper gluconate
  • each gram of compound minerals includes the following elements:
  • Iron 6.0-89.0 mg, preferably 12.0-59.5 mg, eg 6.0, 7.0, 8.0, 9.0, 10.0, 11.0, 12.0, 13.0, 14.0, 15.0, 16.0, 17.0, 18.0, 19.0, 20.0, 21.0, 22.0, 23.0, 24.0, 25.0, 26.0, 27.0, 28.0, 29.0, 30.0, 31.0, 32.0, 33.0, 34.0, 35.0, 36.0, 37.0, 38.0, 39.0, 40.0, 41.0, 42.0, 43.0, 44.0, 45.0, 46.0, 47.0, 4 8.0, 49.0, 50.0, 51.0, 52.0, 53.0, 54.0, 55.0, 56.0, 57.0, 58.0, 59.0, 60.0, 61.0, 62.0, 63.0, 64.0, 65.0, 66.0, 67.0, 68.0, 69.0, 70.0, 71.0, 72.0, 7 3.0, 74.0, 75.0, 76.0, 77.0, 78.0,
  • Zinc 3.5-75.0 mg, preferably 7.0-55.2 mg, eg 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 7.0, 8.0, 9.0, 10.0, 11.0, 12.0, 13.0, 14.0, 15.0, 16.0, 17.0, 18.0, 19.0, 20.0, 21.0, 22.0, 23.0, 24.0, 25.0, 26.0, 27.0, 28.0, 29.0, 30.0, 31.0, 32.0, 33.0, 34.0, 35.0, 36.0, 37.0, 38.0, 39.0, 40.0, 41.0, 42.0, 4 3.0, 44.0, 45.0, 46.0, 47.0, 48.0, 49.0, 50.0, 51.0, 52.0, 53.0, 54.0, 55.0, 56.0, 57.0, 58.0, 59.0, 60.0, 61.0, 62.0, 63.0, 64.0, 65.0, 66.0, 67.0, 6 8.0, 69.0, 70.0, 71.0, 72.0, 73.0, 7
  • 45-400 ⁇ g preferably 84-294 ⁇ g, such as 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200, 205, 210, 215, 220, 225, 230, 235, 240, 245, 250, 255, 260, 265, 270, 275, 280, 285, 290, 295, 300, 305, 310, 315, 320, 325, 330, 335, 340, 345, 350, 355, 360, 365, 370, 375, 380, 385, 390, 395, 400 ⁇ g, or a range defined by any two thereof and any values and subranges subsumed within that range;
  • Iodine 20-900 ⁇ g, preferably 40-560 ⁇ g, for example 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200, 205, 210, 215, 220, 225, 230, 235, 240, 245, 250, 255, 260, 265, 270, 275, 280, 285, 290, 295, 300, 305, 310, 315, 320, 325, 330, 335, 340, 345, 350, 355, 360, 365, 370, 375, 380, 385, 390, 395, 400, 405, 410, 415, 420, 425, 430, 435, 440, 445, 450, 455, 460, 465, 470, 4
  • 300-4200 ⁇ g preferably 600-2800 ⁇ g, for example 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1050, 1100, 1150, 1200, 1250, 1300, 1350, 1400, 1450, 1500, 1550, 1600, 1650, 1700, 1750, 1800, 1850, 1900, 1950, 2000, 2050, 2100, 2150, 2200, 2250, 2300, 2350, 2400, 2 450 ⁇ 2500, 2550, 2600, 2650, 2700, 2750, 2800, 2850, 2900, 2950, 3000, 3050, 3100, 3150, 3200, 3250, 3300, 3350, 3400, 3450, 3500, 3550, 3600, 3650, 3 700, 3750, 3800, 3850, 3900, 3950, 4000, 4050, 4100, 4150, 4200 ⁇ g, or ranges defined by any two thereof
  • Selenium 10-130 ⁇ g, preferably 24-98 ⁇ g, for example 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, 125, 130 ⁇ g, or a range defined by any two thereof and any value and subrange subsumed within that range.
  • each gram of compound minerals includes the following elements: iron: 12.0-59.5mg, zinc: 7.0-55.2mg, magnesium: 19.8-79.0mg, manganese: 84- 294 ⁇ g, iodine: 40-560 ⁇ g, copper: 600-2800 ⁇ g, selenium: 24-98 ⁇ g.
  • the compound minerals further include magnesium, manganese, iodine, copper, selenium in addition to a part or all of iron derived from ferrous gluconate and a part or all of zinc derived from zinc gluconate and/or zinc citrate
  • magnesium, manganese, iodine, copper, selenium in addition to a part or all of iron derived from ferrous gluconate and a part or all of zinc derived from zinc gluconate and/or zinc citrate
  • One or more of them, especially all of them can more balance the nutrition needed by the human body, better promote the improvement of the body's immune system, enhance the body's immunity, reduce the risk of various diseases, etc., and at the same time can promote nutrition. Partial digestion and absorption.
  • the amount of compound vitamins can be 0.15-1.33, preferably 0.2-1.1, such as 0.15, 0.16, 0.17, 0.18, 0.19, 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.30, 0.31, 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.40, 0.41, 0.42, 0.43, 0 .44, 0.45, 0.46, 0.47, 0.48, 0.49, 0.50, 0.51, 0.52, 0.53, 0.54, 0.55, 0.56, 0.57, 0.58, 0.59, 0.60, 0.61, 0.62, 0.63, 0.64, 0.65, 0.66, 0.67, 0.68, 0 .69, 0.70, 0.71, 0.72, 0.73, 0.74, 0.75, 0.76, 0.77, 0.78, 0.79, 0.80, 0.81, 0.82, 0.83, 0.15, 0.16, 0.17, 0.18, 0.19, 0.20, 0.
  • the amount of compound minerals can be 0.15-1.33 in terms of mass parts, preferably 0.2-1.1, such as 0.15, 0.16, 0.17, 0.18, 0.19 , 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.30, 0.31, 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.40, 0.41, 0.42, 0.43, 0.44 , 0.45, 0.46, 0.47, 0.48, 0.49, 0.50, 0.51, 0.52, 0.53, 0.54, 0.55, 0.56, 0.57, 0.58, 0.59, 0.60, 0.61, 0.62, 0.63, 0.64, 0.65, 0.66, 0.67, 0.68, 0.69 , 0.70, 0.71, 0.72, 0.73, 0.74, 0.75, 0.76, 0.77, 0.78, 0.79, 0.80, 0.81, 0.82, 0.83
  • the mass ratio of compound vitamins: compound minerals: calcium citrate may be (0.15-1.33): (0.15-1.33): 1, preferably ( 0.2-1.1):(0.2-1.1):1.
  • vitamin A retinyl palmitate
  • vitamin E d- ⁇ -tocopheryl acetate
  • vitamin B1 sulfur hydrochloride amine
  • vitamin D cholesterol
  • vitamin K 1 phytoanisole
  • vitamin B 2 riboflavin
  • vitamin B 6 pyridoxine hydrochloride
  • vitamin B 12 cyanocobalamin
  • niacin nicotinamide
  • folic acid folic acid
  • pantothenic acid D - calcium pantothenate
  • vitamin C sodium L-ascorbate
  • Each gram of compound minerals contains the following ingredients: iron (ferrous gluconate): 10-63.75mg, zinc (zinc citrate): 6-27mg, magnesium (magnesium sulfate): 16.5-79mg, manganese (manganese sulfate): 70 -315 ⁇ g, iodine (potassium iodate): 33.5-600 ⁇ g, copper (copper sulfate): 500-3000 ⁇ g, selenium (sodium selenite): 20-105 ⁇ g, and the balance is excipients (maltodextrin).
  • the mass ratio of compound vitamins: compound minerals: calcium citrate is 0.15-1.33:0.15-1.33:1.
  • the nutritional composition of the present invention can be added to formula foods such as infant formula (such as infant formula milk powder), children's formula modified milk or milk powder, or adult formula modified milk or milk powder to prepare specific functions (such as Compared with existing formula foods such as formula foods for infants and young children, the present invention has obvious advantages and makes up for the nutritional composition of the market in this respect. points of demand.
  • infant formula such as infant formula milk powder
  • children's formula modified milk or milk powder or adult formula modified milk or milk powder
  • the present invention relates to a formula comprising a nutritional composition according to any embodiment of the present invention.
  • the formula is an infant formula.
  • the formula food is modulated formula milk or milk powder for children.
  • the formula food is adult formula modulated milk or milk powder.
  • the infant formula is infant formula milk powder.
  • the nutritional composition in terms of mass Usage amount can be 0.6-1.8%, preferably 0.7-1.4%, such as 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, 0.95%, 1.0%, 1.05%, 1.10%, 1.15%, 1.20%, 1.25%, 1.30%, 1.35%, 1.40%, 1.45%, 1.50%, 1.55%, 1.60%, A range defined by 1.65%, 1.70%, 1.75%, 1.80%, or any two thereof and any values and subranges subsumed within that range.
  • the compound vitamin derived from the The mass content of the nutritional composition
  • the compound vitamin can be about 0.1-1%, preferably about 0.3-0.5%, such as 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, 0.45%, 0.50% , 0.55%, 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, 0.95%, 1.0%, or the range defined by any two thereof and any value and sub- scope.
  • the compound mineral (derived from The mass content of the nutritional composition) can be about 0.1-1%, preferably about 0.3-0.5%, such as 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, 0.45%, 0.50 %, 0.55%, 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, 0.95%, 1.0%, or the range defined by any two thereof and any value included in the range and subranges.
  • the nutritional composition When the nutritional composition is added to formula food such as infant formula food, such as infant formula milk powder, children's formula modified milk or milk powder, adult formula modified milk or milk powder, the nutritional composition can balance the human body's needs. All aspects of nutrition, while enhancing the body's immunity, and promoting the digestion and absorption of nutritional components.
  • the present invention also relates to the above-mentioned nutritional composition or the above-mentioned food in enhancing the body's immunity, promoting digestion and absorption (or improving the bioavailability of trace elements), especially vitamin A, vitamin E and vitamin B1 and iron , zinc and calcium digestion and absorption for non-therapeutic purposes.
  • Choline chloride (choline content 72.5%): Beijing Jinkangpu Food Technology Co., Ltd.
  • Fructo-oligosaccharide Baolingbao Biological Co., Ltd.
  • a nutritional composition for infant formula consisting of compound vitamins, compound minerals and calcium citrate, the ratio of compound vitamins: compound minerals: calcium citrate is 0.5:0.5:1, the present invention
  • the usage amount of the nutritional composition in the infant formula is 1.2% by weight.
  • each gram of compound vitamin composition includes the following components: vitamin A: 2000 ⁇ g RE, vitamin D: 60 ⁇ g, vitamin E: 40 mg ⁇ -TE, vitamin K1 : 350 ⁇ g, vitamin B1 : 3.5 mg, vitamin B2 : 1600 ⁇ g, vitamin B6 : 2.5mg, vitamin B12 : 8 ⁇ g, niacin: 17mg, folic acid: 530 ⁇ g, pantothenic acid: 11mg, vitamin C: 500mg, biotin: 60 ⁇ g, taurine 180mg, and the rest is lactose.
  • each gram of the compound mineral composition includes the following elements: magnesium: 60mg, iron: 20mg, zinc: 18mg, manganese: 200 ⁇ g, iodine: 420 ⁇ g, copper: 1500 ⁇ g, selenium: 66 ⁇ g, and the rest is lactose.
  • the compound sources of the vitamins are: vitamin A is derived from retinyl palmitate, vitamin D is derived from cholecalciferol, vitamin E is derived from d-alpha-tocopheryl acetate, vitamin K1 is derived from phytonadione, vitamin B 1 is derived from thiamine hydrochloride, vitamin B 2 is derived from riboflavin, vitamin B 6 is derived from pyridoxine hydrochloride, vitamin B 12 is derived from cyanocobalamin, niacin is derived from niacinamide, folic acid is derived from folic acid (pteroyl glutamic acid), pantothenic acid from D-calcium pantothenate, vitamin C from L-sodium ascorbate, and biotin from D-biotin.
  • the compound sources of the mineral elements are: magnesium is derived from magnesium sulfate, iron is derived from ferrous gluconate, zinc is derived from zinc citrate, manganese is derived from manganese sulfate, copper is derived from copper sulfate, iodine is derived from potassium iodate, selenium Derived from sodium selenite.
  • a nutritional composition for formula food for older infants consisting of compound vitamins, compound minerals and calcium citrate, the ratio of compound vitamins: compound minerals: calcium citrate is 0.35:0.35:1,
  • the usage amount of the nutritional composition of the present invention in formula food for older infants is 1.45% by weight.
  • each gram of compound vitamin composition includes the following components: vitamin A: 2300 ⁇ g RE, vitamin D: 60 ⁇ g , vitamin E: 40 mg ⁇ -TE, vitamin K1 : 250 ⁇ g, vitamin B1: 3.3 mg, vitamin B2 : 1700 ⁇ g, vitamin B6 : 2.0mg, vitamin B12 : 7 ⁇ g, niacin: 15mg, folic acid: 400 ⁇ g, pantothenic acid: 11mg, vitamin C: 400mg, biotin: 35 ⁇ g, taurine 180mg, and the rest is lactose.
  • each gram of the compound mineral composition includes the following elements: magnesium: 50mg, iron: 26mg, zinc: 13.5mg, manganese: 150 ⁇ g, iodine: 220 ⁇ g, copper: 1200 ⁇ g, selenium: 40 ⁇ g, and the rest is lactose.
  • the compound sources of the vitamins are: vitamin A is derived from retinyl palmitate, vitamin D is derived from cholecalciferol, vitamin E is derived from d-alpha-tocopheryl acetate, vitamin K1 is derived from phytonadione, vitamin B 1 is derived from thiamine hydrochloride, vitamin B 2 is derived from riboflavin, vitamin B 6 is derived from pyridoxine hydrochloride, vitamin B 12 is derived from cyanocobalamin, niacin is derived from niacinamide, folic acid is derived from folic acid (pteroyl glutamic acid), pantothenic acid from D-calcium pantothenate, vitamin C from L-sodium ascorbate, and biotin from D-biotin.
  • the compound sources of the mineral elements are: magnesium is derived from magnesium sulfate, iron is derived from ferrous gluconate, zinc is derived from zinc citrate, manganese is derived from manganese sulfate, copper is derived from copper sulfate, iodine is derived from potassium iodate, selenium Derived from sodium selenite.
  • a nutritional composition for formula food for infants consisting of compound vitamins, compound minerals and calcium citrate, the ratio of compound vitamins: compound minerals: calcium citrate is 0.35:0.35:1, the present invention
  • the usage amount of the nutritional composition in the formula food for older infants is 1.45% by weight.
  • each gram of compound vitamin composition includes the following components: vitamin A: 2300 ⁇ g RE, vitamin D: 60 ⁇ g, vitamin E: 40 mg ⁇ -TE, vitamin K1 : 250 ⁇ g, vitamin B1: 3.3 mg, vitamin B2 : 1700 ⁇ g, vitamin B6 : 2.0mg, vitamin B12 : 7 ⁇ g, niacin: 15mg, folic acid: 400 ⁇ g, pantothenic acid: 11mg, vitamin C: 400mg, biotin: 35 ⁇ g, Taurine 180mg, the rest is lactose.
  • each gram of the compound mineral composition includes the following elements: magnesium: 35mg, iron: 28mg, zinc: 12mg, manganese: 150 ⁇ g, iodine: 80 ⁇ g, copper: 1300 ⁇ g, selenium: 50 ⁇ g, and the rest is lactose.
  • the compound sources of the vitamins are: vitamin A is derived from retinyl palmitate, vitamin D is derived from cholecalciferol, vitamin E is derived from d-alpha-tocopheryl acetate, vitamin K1 is derived from phytonadione, vitamin B 1 is derived from thiamine hydrochloride, vitamin B 2 is derived from riboflavin, vitamin B 6 is derived from pyridoxine hydrochloride, vitamin B 12 is derived from cyanocobalamin, niacin is derived from niacinamide, folic acid is derived from folic acid (pteroyl glutamic acid), pantothenic acid from D-calcium pantothenate, vitamin C from L-sodium ascorbate, and biotin from D-biotin.
  • the compound sources of the mineral elements are: magnesium is derived from magnesium sulfate, iron is derived from ferrous gluconate, zinc is derived from zinc citrate, manganese is derived from manganese sulfate, copper is derived from copper sulfate, iodine is derived from potassium iodate, selenium Derived from sodium selenite.
  • a nutritional composition for children's formula food which consists of compound vitamins, compound minerals and calcium citrate, the ratio of compound vitamins: compound minerals: calcium citrate is 0.2:0.2:1, the present invention
  • the usage amount of the nutritional composition in the infant formula is 1.4% by weight.
  • each gram of compound vitamin composition includes the following components: vitamin A: 2000 ⁇ g RE, vitamin D: 45 ⁇ g, vitamin E: 35 mg ⁇ -TE, vitamin B1 : 4.0 mg, vitamin C: 350 mg, and the rest is lactose.
  • each gram of the compound mineral composition comprises the following elements: magnesium: 20mg, iron: 46mg, zinc: 50mg, and the rest is lactose.
  • vitamin A is derived from retinyl palmitate
  • vitamin D is derived from cholecalciferol
  • vitamin E is derived from d- ⁇ -tocopheryl acetate
  • vitamin B1 is derived from thiamine hydrochloride
  • vitamin C is derived from In sodium L-ascorbate
  • biotin is derived from D-biotin.
  • the compound sources of the mineral elements are: magnesium is derived from magnesium sulfate, iron is derived from ferrous gluconate, zinc is derived from zinc citrate and zinc gluconate, wherein zinc derived from zinc citrate and zinc derived from zinc gluconate The zinc ratio is 1:1.
  • the used raw materials of the milk powder of the present invention include: 200 parts of raw milk (on a dry basis), 30 parts of concentrated whey protein powder, 400 parts of desalted whey powder, 127.5 parts of lactose, 25 parts of fructooligosaccharides, 200 parts of mixed vegetable oil, 1.5 parts of choline chloride, 2 parts of sodium citrate, 2 parts of potassium chloride, 12 parts of nutritional composition of embodiment 1 (percentage by weight 1.2%); Concentrate and spray-dry to form a powdery semi-finished product, and carry out nitrogen-filled packaging to obtain the final product.
  • the raw materials used in the milk powder of the present invention include: 200 parts of raw milk (on a dry basis), 30 parts of concentrated whey protein powder, 250 parts of desalted whey powder, 75 parts of skimmed milk powder, 250 parts of lactose, and 25 parts of fructooligosaccharides , 150 parts of mixed vegetable oil, 1.5 parts of choline chloride, 2 parts of sodium citrate, 2 parts of potassium chloride, 14.5 parts of the nutritional composition of Example 2 (1.45% by weight); , pasteurization, evaporative concentration and spray drying into a powdery semi-finished product, which is packed with nitrogen to obtain the final product.
  • the raw materials used in the milk powder of the present invention include: 260 parts of raw milk (on a dry basis), 20 parts of concentrated whey protein powder, 250 parts of desalted whey powder, 125 parts of skimmed milk powder, 175 parts of lactose, and 25 parts of fructooligosaccharides , 125 parts of mixed vegetable oil, 1.5 parts of choline chloride, 2 parts of sodium citrate, 2 parts of potassium chloride, 14.5 parts of nutritional composition of embodiment 3 (1.45% by weight); , pasteurization, evaporative concentration and spray drying into a powdery semi-finished product, which is packed with nitrogen to obtain the final product.
  • a kind of application of the nutritional composition of children's formula food in children's formula milk powder every 1000 parts of children's formula milk powder are made of the following components by weight:
  • the raw materials used in the milk powder of the present invention include: 360 parts of raw milk (on a dry basis), 30 parts of concentrated whey protein powder, 300 parts of desalted whey powder, 150 parts of skimmed milk powder, 50 parts of maltodextrin, fructooligosaccharide 30 parts, 60 parts of mixed vegetable oil, 14 parts of nutritional composition of embodiment 4 (1.4% by weight); Nitrogen packaging is the final product.
  • Animal experiments mainly verify the differences in immune function and digestion and absorption rate between the preferred composition of vitamin A, vitamin E, vitamin B 1 , calcium, iron and zinc in this program and the original composition, and enhance the immune function of the preferred components. Evaluate the bioavailability of energy and trace elements, and conduct animal experiments to verify it, and provide support for product development.
  • BCA method protein content determination kit rat interleukin 2 (IL-2) ELISA kit, rat interleukin 4 (IL-4) ELISA kit, rat interferon gamma (IFN- ⁇ ) ELISA kit, Rat Immunoglobulin A (IgA) ELISA Kit, Rat Immunoglobulin G (IgG) ELISA Kit, Rat Immunoglobulin M (IgM) ELISA Kit.
  • Nitric acid 65% was purchased from Merck, Germany, high-purity water was provided by Milli-Q Advantage ultrapure water system, acetonitrile and methanol (Fisher, USA).
  • Microplate reader Labsystems Multiskan MS (Finland); electronic balance: BS-110S, Beijing Sartorius Balance Co., Ltd.; TG16W micro high-speed centrifuge; desktop centrifuge: type 5424R, Eppendorf (Germany); electronic balance: Mettler XS105DU (Switzerland); AC8 plate washer: Thermo Labsystems (Finland); GNP-9080 water-proof constant temperature incubator; vortex instrument, water bath, tissue homogenizer.
  • Atomic absorption spectrometer PinA Acle 900T, Perkin Elmer Company
  • UPLC chromatograph Accucore Vanquish series (including high-pressure binary system pump, automatic sampler, diode array detector, fluorescence detector, American Thermo Fisher Scientific Co., Ltd.
  • the sources of vitamin A, vitamin E, vitamin B 1 , and iron compounds in the nutritional compositions of experimental groups 3, 4, and 5 were retinyl palmitate, d- ⁇ -tocopheryl acetate, thiamine hydrochloride, and gluconate, respectively.
  • the sources of iron and zinc are zinc gluconate, zinc citrate, zinc gluconate+zinc citrate (1:1), and the calcium used in combination is calcium citrate.
  • the active ingredients of each nutrient have the same content. See Table 3 for the addition details.
  • Rat feed in each experimental group was provided by Beijing HFK Bioscience CO., LTD according to the nutrient formula of each group. Newly weaned rats were adaptively fed After breeding, they were randomly divided into groups of 8, and were given custom-made sample feeds, and the formal experiment began.
  • mice Weigh every week, and record the body weight and feed consumption of the mice.
  • Rats in each group took blood from the orbital venous plexus at 1, 2, 3, 4 and 5 weeks respectively, 1.2-1.5mL per rat, let stand for 30min after blood collection, centrifuged at 3000r/min for 10min, and took serum in -80°C refrigerator Stored for the detection of immune factors IL-2, IL-4, IFN- ⁇ and immunoglobulins IgM, IgA, IgG in rat serum.
  • the animal experiment was carried out until the end of the fifth week, and the rats were given anesthesia, blood was collected from the heart, left to stand for 30 minutes, 3000r/min, centrifuged for 10 minutes, and the serum was stored at -80°C for vitamin A, E and B1 in the serum, as well as immune factors Immediately after the blood was collected, the heart, liver, kidney, spleen, and femurs on both sides were dissected, and the heart, liver, kidney, and spleen were weighed and recorded. The liver and kidneys were bagged and placed in an ice box. Re-record, vernier caliper to measure the length and record the diameter at the midpoint of the femur. The measured femur was also bagged and stored in an ice box. After all the experiments were completed, it was stored in a -80°C refrigerator. The liver, kidney and bones were used for the analysis and detection of Ca, Fe, and Zn elements.
  • IL-2 is one of the earliest discovered cytokines, also known as T cell growth factor, which can promote the proliferation of T cells, induce their differentiation and apoptosis.
  • IL-4 is mainly secreted by activated T cells and mononuclear cells. It can stimulate the growth and proliferation of B cells, promote and regulate the production of IgE, promote the growth and proliferation of T cells, but inhibit the function of Th1 cells and other biological functions.
  • IFN- ⁇ is a multifunctional active protein produced by monocytes and lymphocytes. It activates phagocytes to kill antigens and tumor cells, and strengthens neutrophils to enhance the killing activity of NK cells, so as to achieve the goal of protecting the body. The lethality of tumor cells, resulting in the apoptosis of tumor cells. Therefore, this experiment compares and evaluates the influence of the composition of the present invention on the immune function of rats by measuring the secretion levels of IL-2, IL-4 and IFN- ⁇ in rat serum.
  • Blood was collected from the orbital venous plexus of the rats in each group at 1, 2, 3, 4, and 5 weeks respectively, and 1.2-1.5 mL of blood was collected from each rat. After blood collection, it was left to stand for 30 minutes, centrifuged at 3000 r/min for 10 minutes, and the serum was collected in a -80°C refrigerator. Stored, and ELISA kits were used to detect immune factors IL-2, IL-4, and IFN- ⁇ in serum.
  • Immunoglobulin refers to a globulin with antibody activity or a chemical structure similar to an antibody. Immunoglobulin is a receptor on the surface of B lymphocytes, which plays an important role in various cell activities such as cell activation and differentiation. Immunoglobulins are secreted into blood or other body fluids and can bind to the corresponding antigen, which results in direct neutralization of foreign antigens, or as an initial trigger to initiate and recruit effector systems, such as activation of complement or mononuclear phagocyte-mediated Antibody-dependent cell lysis. This experiment compares and evaluates the effect of breastmilk nutrition on the immune function of rats by measuring the secretion content of immunoglobulin IgM, IgA and IgG in rat serum.
  • Blood was collected from the orbital venous plexus of the rats in each group at 1, 2, 3, 4, and 5 weeks respectively, and 1.2-1.5 mL of blood was collected from each rat. After blood collection, it was left to stand for 30 minutes, centrifuged at 3000 r/min for 10 minutes, and the serum was collected in a -80°C refrigerator. Stored, and ELISA kits were used to detect the immunoglobulins IgM, IgA, and IgG in the serum.
  • Vitamin A, E serum sample processing method thaw the frozen serum naturally at room temperature and in the dark, shake and mix. Take 1ml of rat serum, put it in a 10ml centrifuge tube, add 3ml of methanol-acetonitrile 2:1 mixed solvent, mix well, vortex for 30s, ultrasonic for 1min, stand at room temperature for 15min to precipitate protein, then add 4.5ml of n-hexane, Vortex, extract for 1min, centrifuge at 10000r for 5min, take 4ml of the supernatant organic layer and place it in a 5ml EP tube, dry it with nitrogen at room temperature, add 500ul of methanol to the residue to redissolve, ultrasonically dissolve, and perform HPLC determination.
  • Vitamin B 1 sample processing method take 500 ⁇ L of serum and place it in an EP tube, add 50 ⁇ L of 0.5 mmol/L sodium hydroxide solution, and vortex for 30 seconds. Add 5 mL of ethyl acetate, vortex for 3 min, centrifuge at 5000 r/min at 4°C for 5 min, remove 4 mL of supernatant, and blow dry with nitrogen in a water bath at 37°C. Take 200 ⁇ L of the residue for reconstitution, and take 20 ⁇ L for HPLC analysis.
  • Ca, Fe, Zn sample processing Accurately weigh 0.3g-0.5g of liver, kidney and bone samples into a polytetrafluoroethylene digestion tube, add 8mL of nitric acid, and digest the samples according to the operation steps of microwave digestion.
  • the digestion conditions are shown in the table 3. After cooling, take out the digestion tube and concentrate to about 1 mL on an electric furnace at 160°C. After cooling the digestion tube, transfer the digestion solution to a 10mL volumetric flask, wash the digestion tube 2 to 3 times with a small amount of water, put the washing solution in the volumetric flask and dilute to the mark with water. Dilute according to actual measurement needs, mix well for later use, and use flame atomic absorption spectrometry for detection.
  • Interleukin-2 and interferon- ⁇ mediate cellular immunity.
  • IL-2 stimulates the proliferation of activated B cells to secrete immunoglobulin, and at the same time induces the growth and differentiation of T cells to produce IFN- ⁇ .
  • interleukin-2 enhanced the cytotoxicity of T lymphocytes and natural killer cells.
  • INF- ⁇ activates macrophages to engulf antigens and specifically kill pathogenic microorganisms.
  • IL-4 is mainly produced by activated T-nuclear monocytes, stimulates B-cell proliferation, promotes and regulates IgE production, stimulates T-cell growth, and induces many inflammatory responses.
  • the contents of immune factors IL-2, IL-4, IFN- ⁇ , Ig-A, IgG and Ig-M in the experimental animal serum of the experimental group and the control group were between 1 and 4. week showed a gradually increasing trend, and reached the peak in the 4th week, and the contents of the above indicators in the experimental group 1 were higher than that of the control group 1, and the contents of the experimental group 2 were higher than that of the control group 2; better than the control group. Supplementing new nutrients keeps enhancing the immune function, which can significantly increase the level of immunoglobulin in the blood.
  • the contents of the active ingredients in the experimental groups 3-5 are equal, and the experimental group 5 is equivalent to half of the sum of the experimental groups 3 and 4 in terms of active ingredients.
  • the results of the experimental group 5 are generally better than half of the sum of the results of the experimental group 3 and the experimental group 4, showing that in zinc gluconate and lemon There is a synergistic effect between zinc and acid zinc.
  • retinyl palmitate, d-alpha-tocopheryl acetate, thiamine hydrochloride, ferrous gluconate, gluconic acid Zinc and/or zinc citrate, and the combination of calcium citrate will obviously be better than retinyl acetate, retinyl acetate, Combination of dl-alpha-tocopheryl acetate, thiamine nitrate, ferrous sulfate, zinc sulfate, calcium carbonate.

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Abstract

La présente invention concerne une composition nutritionnelle destinée à être utilisée dans un produit alimentaire de formule, la composition nutritionnelle contenant ou étant constituée des éléments suivants : (1) des vitamines composées qui comprennent de la vitamine A qui est partiellement ou entièrement dérivée du palmitate de rétinyle ; de la vitamine E qui est partiellement ou entièrement dérivée de l'acétate de d-α-tocophéryle et/ou du d-α-tocophérol ; et de la vitamine B1 qui est partiellement ou entièrement dérivée du chlorhydrate de thiamine ; (2) des minéraux composés qui comprennent du fer qui est partiellement ou entièrement dérivé du gluconate ferreux ; et du zinc qui est partiellement ou entièrement dérivé du gluconate de zinc et/ou du citrate de zinc ; et (3) du citrate de calcium. La présente invention concerne en outre un produit alimentaire de formule contenant la composition nutritionnelle, et l'utilisation non thérapeutique de la composition nutritionnelle ou du produit alimentaire de formule pour améliorer l'immunité du corps et améliorer la biodisponibilité d'éléments traces.
PCT/CN2023/075719 2022-03-02 2023-02-13 Composition nutritionnelle, produit alimentaire de formule et utilisation WO2023165323A1 (fr)

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