WO2023143004A1 - 注液装置、检测方法及医疗设备 - Google Patents

注液装置、检测方法及医疗设备 Download PDF

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Publication number
WO2023143004A1
WO2023143004A1 PCT/CN2023/071328 CN2023071328W WO2023143004A1 WO 2023143004 A1 WO2023143004 A1 WO 2023143004A1 CN 2023071328 W CN2023071328 W CN 2023071328W WO 2023143004 A1 WO2023143004 A1 WO 2023143004A1
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WIPO (PCT)
Prior art keywords
liquid injection
liquid
nozzle
bottle body
assembly
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PCT/CN2023/071328
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English (en)
French (fr)
Inventor
孟杰
余波
章铖皓
童明
罗伟
赵逸祥
张凯君
Original Assignee
浙江普施康生物科技有限公司
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Publication of WO2023143004A1 publication Critical patent/WO2023143004A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0484—Cantilevers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106—General arrangement of respective parts
    • G01N2021/0112—Apparatus in one mechanical, optical or electronic block

Definitions

  • the invention relates to the technical field of medical devices, in particular to a liquid injection device, a detection method and medical equipment.
  • microfluidic technology In recent years, biochemical detection is often realized by microfluidic technology.
  • the microfluidic device used for biochemical detection is pre-packaged with reaction materials, such as freeze-dried reagent balls.
  • reaction materials such as freeze-dried reagent balls.
  • microfluidic devices need to Add reagents.
  • the addition of reagents is often done by manually holding the pipette, adjusting the pipette to the required liquid volume, and then pressing the pipette to complete the extraction.
  • This method has high requirements on the operation method, and the price of high-precision pipette is relatively high, and each extraction requires a pipette tip, which is cumbersome and time-consuming.
  • the main purpose of the present invention is to provide a liquid injection device, a detection method and medical equipment to solve the problem of cumbersome operation in the diluent addition process of the biochemical detector in the prior art.
  • the present invention provides a liquid injection device, comprising: a mounting bracket and a diluent container, the diluent container is arranged on the mounting bracket, the diluent container includes a bottle body, a nozzle and a suction assembly, the nozzle is arranged on the bottle body, the nozzle is provided with a liquid outlet, the suction assembly is arranged on the nozzle and communicates with the bottle body and the liquid outlet, The suction component sucks the diluent in the bottle body to the liquid outlet by the pressing force exerted by the nozzle; and the liquid injection component is arranged on the mounting bracket, and the injection component
  • the liquid assembly includes a liquid injection arm, and the liquid injection arm moves along the axial or radial direction of the bottle body to directly or indirectly apply pressing force to the nozzle.
  • the liquid injection device further includes a driving assembly, the driving assembly is arranged on the mounting bracket, and the driving assembly is drivingly connected with the liquid injection assembly to drive the liquid injection arm along the axis of the bottle body. To or radial movement.
  • the liquid injection assembly further includes a fixing part, and the liquid injection arm is arranged on the fixing part;
  • the driving assembly includes a driving motor, which is drivingly connected to the fixing member to drive the liquid injection arm to move axially or radially along the bottle body.
  • the driving motor is a linear motor
  • the fixing member is connected to the output shaft of the linear motor to drive the liquid injection arm to move axially along the bottle body under the drive of the linear motor
  • the drive motor is a rotary drive motor
  • the output shaft of the rotary drive motor is connected to the fixed part through a screw
  • the rotation of the rotary drive motor drives the screw to rotate to drive the fixed part and the fixed part
  • the liquid injection arm moves axially along the bottle body
  • the drive motor is a rotary drive motor
  • the output shaft of the rotary drive motor is connected with the fixing member to drive the liquid injection arm along the axis of the bottle. radial movement of the body.
  • a guide rod is provided on the installation bracket, and the guide rod is passed through the fixing member to limit and guide the fixing member.
  • the installation bracket is provided with a positioning part, and the diluent container is detachably arranged on the positioning part; the fixing member moves along the axial direction of the bottle body, and the liquid injection arm is rotatable Connected to the fixing part, the liquid injection arm has an avoidance position avoiding the positioning part and a pressing position above the positioning part.
  • the liquid injection assembly further includes an operation handle, and the operation handle is arranged on the liquid injection arm to switch the liquid injection arm between the avoidance position and the pressing position.
  • the liquid injection device further includes a controller and a position detection element, the position detection element is arranged on the installation bracket to detect the position of the liquid injection assembly, the position detection element and the driving The components are all electrically connected to the controller, and the controller controls the driving component according to the signal transmitted by the position detection element.
  • the positioning part is a positioning hole, and the diluent container is set upside down in the positioning hole.
  • the present invention also provides a medical device, the medical device includes a liquid injection device, and the liquid injection device is the above-mentioned liquid injection device.
  • the present invention also provides a detection method, comprising the following steps:
  • liquid injection device described in the first aspect of the present application to inject diluent into the microfluidic disc
  • the microfluidic disc is driven to rotate, so as to separate the samples contained in the microfluidic disc and make the samples react with the reagents.
  • liquid injection device described in the first aspect of the present application to inject reagents into the microfluidic disk includes the following steps:
  • the diluent container is installed so that the liquid outlet of the diluent container communicates with the microfluidic disk; the liquid injection arm is used to apply pressure to the bottle body, so that the diluent container injects liquid into the microfluidic disk.
  • liquid injection device of the present invention does not need to be manually held and pressed when the pipette is used, but the addition and perfusion of the diluent can be realized only through the movement of the liquid injection arm. The detection efficiency of the equipment.
  • Fig. 1 is the schematic diagram of the three-dimensional structure of the medical equipment of the present invention.
  • Fig. 2 is a schematic structural view of the liquid injection device of the present invention during liquid injection;
  • Fig. 3 is a schematic structural view of the liquid injection device of the present invention installed in the medical device;
  • Fig. 4 is a partial sectional view of the liquid injection device of the present invention.
  • Fig. 5 is a partial structural schematic diagram of the buffer mechanism installed in the liquid injection device of the present invention.
  • FIG. 6 is a cross-sectional view of the partial structure of FIG. 5 .
  • a medical device 100 is provided.
  • the medical device 100 in this embodiment especially refers to a medical device 100 such as a biochemical detector or a luminescence detector.
  • the medical device 100 in this embodiment includes a base 110 and a liquid injection device disposed above the base 110 .
  • a tray 130 is arranged on the base 110 , the tray 130 can be rotated under the drive of the motor 120 , and the tray 130 is used for placing the microfluidic disc 140 .
  • the microfluidic disk 140 is placed on the tray 130, and then the sample to be tested is injected into the microfluidic disk 140, and then the diluent is added to the microfluidic disk 140 by using a liquid injection device, so that the pre-packaged The freeze-dried reagent balls in the microfluidic disk 140 are diluted, and then the motor 120 is used to drive the tray 130 and the microfluidic disk 140 placed on the tray 130 to rotate, that is, the samples contained in the microfluidic disk 140 can be separated. And make the sample react with the reagent, and finally use the pre-installed light source and detector on the medical device 100 to detect the sample.
  • the present application also discloses a liquid injection device.
  • the liquid injection device in this embodiment includes a mounting bracket 10, a diluent container 20 and a liquid injection assembly 30.
  • the mounting bracket 10 is arranged above the base 110, and the mounting bracket 10 has a positioning part 11, and the positioning part 11 is used for positioning the diluent container 20; the diluent container 20 is detachably arranged on the positioning part 11, Like this, it is convenient to replace the diluent container 20; Liquid port 221, during actual installation, the liquid outlet 221 communicates with the liquid injection port on the microfluidic disc 140 (see Figure 2), the suction assembly is arranged on the nozzle 22 and connected to the bottle body 21 and the liquid outlet 221 Connected, when working, the suction component is subjected to the pressing force exerted by the nozzle 22 to suck the diluent in the bottle body 21 to the liquid outlet 221 (such as the principle of a pump bottle), and then the diluent can be delivered to the microfluidic disk 140;
  • the liquid injection assembly 30 is disposed on the mounting bracket 10 , the liquid injection assembly 30 includes a liquid injection arm 31 , and the liquid injection arm 31 moves along the axial or radial direction of the bottle body 21 to directly or indirectly apply a pressing force to the nozzle 22 .
  • the movement of the liquid injection arm 31 along the axial or radial direction of the bottle body 21 to directly or indirectly apply a pressing force to the nozzle 22 refers to: moving the liquid injection arm 31 along the height direction of the bottle body 21 Apply pressing force directly to the nozzle 22 (for example, make the liquid injection arm 31 move up and down along the height direction of the bottle body 21 to press the nozzle 22), or make the liquid injection arm 31 move along the height direction of the bottle body 21 to indirectly apply the pressure force to the nozzle 22 (For example, make the liquid injection arm 31 move up and down along the height direction of the bottle body 21 to press the bottle body 21 and then press the nozzle 22), or make the liquid injection arm 31 move along the radial direction of the bottle body 21 to directly apply a pressing force to the nozzle 22 (such as Make the liquid injection arm 31 move along the radial direction of the bottle body 21 to press the nozzle 22, at this time, a wedge-shaped surface can be set on the nozzle 22 to cooperate with the liquid injection arm 31), or make the liquid injection arm
  • the diluent container 20 When using the liquid injection device in this embodiment to inject liquid, the diluent container 20 is first installed at the positioning part 11, and the liquid outlet 221 of the diluent container 20 is connected to the structure that needs liquid injection (such as a microfluidic disk) 140) communication, and then make the liquid injection arm 31 move along the axial or radial direction of the bottle body 21, and then apply a pressing force to the nozzle 22, so that the suction assembly can suck the diluent in the bottle body 21 to the liquid outlet 221, and then injected into the structure that needs liquid injection.
  • liquid injection such as a microfluidic disk
  • the mounting bracket 10 in this embodiment is a frame body, as long as it is a frame body structure that facilitates the installation of the diluent container 20 and the liquid injection assembly 30 , etc., it is not specifically limited in this embodiment.
  • the positioning part 11 is set as a positioning hole.
  • the diluent container 20 is set upside down (that is, the nozzle 22 is downwards, and the bottle body 21 is upwards).
  • the diluent container 20 can be sprayed down only by pressing the diluent container 20 with the liquid injection arm 31 . If the liquid outlet 221 of the diluent container 20 is aligned with the structure that needs liquid injection, there is no need to arrange a connecting pipe between the liquid outlet 221 and the structure that needs liquid injection, the structure of the medical device 100 can be simplified, and the dilution The transmission path of the liquid is shorter, which is more suitable for use in precise detection instruments.
  • the diluent container 20 can also be installed on the mounting bracket 10 upright or obliquely.
  • Other variants under the concept of the present invention are within the protection scope of the present invention.
  • the liquid injection device in this embodiment is also provided with a drive assembly 40, the drive assembly 40 is arranged on the mounting bracket 10, by setting the drive assembly 40, the liquid injection arm 31 can be driven along the bottle body 21 moves axially or radially, so that the diluent container 20 can be pressed, and then the diluent inside the diluent container 20 can be sucked to the liquid outlet 221, and then added to the structure that needs to be injected.
  • the liquid process does not require medical staff to press the diluent container 20 , which is highly automated, saves time and labor, and can further improve the detection efficiency of medical equipment 100 such as biochemical detectors.
  • the liquid injection assembly 30 in this embodiment also includes a fixing piece 32, the fixing piece 32 can be a fixed block, for example, and the liquid injection arm 31 is arranged on the fixing piece 32 during actual installation.
  • the driving assembly 40 includes a driving motor, which is drivingly connected to the fixing member 32, so as to drive the liquid injection arm 31 to move axially or radially along the bottle body 21, and the structure is stable and reliable.
  • the driving motor is set as a linear motor.
  • the fixing member 32 is connected with the output shaft of the linear motor to drive the liquid injection arm 31 along the axial direction of the bottle body 21 under the drive of the linear motor.
  • the liquid injection arm 31 reciprocates along the axial direction of the bottle body 21 to press the nozzle 22 to extract the diluent in the bottle body 21 .
  • the drive motor can also be set as a rotary drive motor, the output shaft of the rotary drive motor is connected to the fixing member 32 through a screw, and the rotation of the rotary drive motor drives The screw rotates to drive the fixing part 32 and the liquid injection arm 31 to move along the axial direction of the bottle body 21. At this time, the liquid injection arm 31 reciprocates along the axial direction of the bottle body 21, and the nozzle 22 can be pressed so that the bottle body The diluent in 21 is drawn out.
  • the drive motor can also be set as a rotary drive motor, and the output shaft of the rotary drive motor is connected with the fixing member 32 to drive the injection arm 31 along the diameter of the bottle body 21.
  • a wedge-shaped surface is provided on the diluent container 20, and the liquid injection arm 31 cooperates with the wedge-shaped surface.
  • the driving motor drives the liquid injection arm 31 to move along the radial direction of the bottle body 21, the liquid injection arm 31 moves along the The movement of the wedge-shaped surface can press the diluent container 20, and then the diluent in the bottle body 21 can be sucked out to pour into the structure that needs liquid injection.
  • the installation bracket 10 in this embodiment is provided with a guide rod 50 , and the guide rod 50 passes through the fixing member 32 to limit and guide the fixing member 32 .
  • the guide rod 50 can limit and guide the fixing member 32, and the whole structure is more stable and reliable.
  • the guide rod 50 in this embodiment may be a cylindrical rod or a prismatic rod, as long as it is any other deformation under the concept of the present invention, it is within the protection scope of the present invention.
  • the drive assembly 40 drives the fixing member 32 to move axially along the bottle body 21.
  • the fixing member 32 is above the diluent container 20, when the diluent container 20 After the diluent is used up, it is inconvenient to replace the diluent container 20 .
  • the liquid injection arm 31 is rotatably connected to the fixing member 32 .
  • the liquid injection arm 31 has an avoidance position away from the positioning portion 11 and a pressing position above the positioning portion 11 .
  • the liquid injection arm 31 in this embodiment is connected to the fixing member 32 through the connection pin 312, and the liquid injection arm 31 can rotate relative to the connection pin 312 so as to switch between the avoidance position and the pressing position.
  • the structure is simple and convenient. accomplish.
  • the liquid injection assembly 30 in this embodiment also includes an operation handle 311, which is arranged on the liquid injection arm 31.
  • an operation handle 3111 which is arranged on the liquid injection arm 31.
  • holding the operation handle 311 can make the liquid injection arm 31 in the evacuation position and press the Switch between positions, simple structure, easy to operate.
  • the liquid injection arm 31 in this embodiment is a long arm, one end of the liquid injection arm 31 is connected to the fixing member 32 through the above-mentioned connecting pin 312, and the operating handle 311 is arranged at the other end of the liquid injection arm 31 , when the liquid injection arm 31 is driven to rotate through the operating handle 311, it is more labor-saving, and the operation is simpler and faster.
  • the liquid injection device in this embodiment also includes a controller (not shown in the figure) and a position detection element 60, the position detection element 60 is arranged on the mounting bracket 10 to detect the position of the liquid injection assembly 30, Both the position detection element 60 and the drive assembly 40 are electrically connected to the controller, and the controller controls the drive assembly 40 according to the signal transmitted by the position detection element 60 .
  • the position detection element 60 in this embodiment may be a structure such as a photoelectric switch, a position sensor, etc., and the position detection element 60 is arranged on the mounting bracket 10, specifically at the position of the mounting bracket 10 corresponding to the liquid injection assembly 30 , when the position detection element 60 detects that the liquid injection assembly 30 moves to the initial position, the controller can control the drive assembly 40 to drive the liquid injection assembly 30 to perform the pressing liquid injection action according to the control requirements, when the position detection element 60 detects that the liquid injection assembly When the position 30 moves to the initial position, the controller controls the drive assembly 40 to move until the position detection element 60 sends the liquid injection assembly 30 back to the initial position to the controller. That is to say, the controller and the position detection element 60 are provided in this embodiment, which is convenient to improve the automation of the liquid injection device of the present invention, and can further improve the working efficiency of the medical device 100 of the present invention.
  • the diluent container 20 when injecting liquid through the liquid injection device in the present invention, the diluent container 20 is first installed at the positioning part 11, and the liquid outlet 221 of the diluent container 20 is aligned with the structure that needs liquid injection (such as microfluidic disc 140), and then make the liquid injection arm 31 move along the axial or radial direction of the bottle body 21, and then apply a pressing force to the nozzle 22, so that the suction assembly can suck the diluent in the bottle body 21 to the liquid outlet 221, and then injected into the structure requiring liquid injection.
  • the structure that needs liquid injection such as microfluidic disc 140
  • a buffer mechanism is installed on the nozzle 22, and the buffer mechanism includes a liquid outlet pipe 150, the buffer 151 and the liquid discharge pipe 152, the liquid discharge pipe 150 is fixed on the nozzle 22, the liquid discharge pipe 150 is vertically arranged, the liquid discharge pipe 150 communicates with the liquid outlet 221, and the buffer 151 is fixed on the liquid discharge pipe 150 At the end away from the liquid outlet 221, the buffer 151 is spherical, and the buffer 151 is made of rigid material.
  • the buffer 151 is hollow, and the lower end of the liquid outlet pipe 150 extends into the buffer 151.
  • the liquid discharge pipe 152 On the end opposite to the liquid outlet pipe 150, the liquid discharge pipe 152 is vertically arranged, and the upper end of the liquid discharge pipe 152 extends into the buffer 151.
  • An expansion bag 153 is placed in the buffer 151.
  • the expansion bag 153 is a soft bag, and the expansion bag 153 Expandable and compressible, one end of the liquid outlet pipe 150 and the liquid discharge pipe 152 extending to the buffer 151 is connected to the expansion bag 153, and a one-way valve 154 is installed on the liquid outlet pipe 150, and the one-way valve 154 is used to make the water in the nozzle 22
  • the liquid flows to the expansion bag 153, and a solenoid valve 155 is installed on the discharge pipe 152, and the opening of the solenoid valve 155 is controlled by electricity;
  • An airbag 160 is fixedly connected inside the buffer 151 , and the airbag 160 covers the inflation bag 153 .
  • a buffer cylinder 162 is fixedly connected to the mounting bracket 10.
  • the buffer cylinder 162 is horizontal, and a piston 161 is movably connected in the buffer cylinder 162.
  • the outer wall of the piston 161 is compatible with the inner wall of the buffer cylinder 162. The space between them is sealed.
  • the buffer tube 162 is connected with a connecting pipe 164, and the connecting pipe 164 is connected with the air bag 160.
  • a spring 163 is fixedly connected in the buffer tube 162 along the moving direction of the piston 161.
  • the spring 163 is fixedly connected with the piston 161.
  • the spring 163 is located on the piston 161.
  • a pressure relief port 165 is opened on the side of the buffer cylinder 162 close to the spring 163.
  • the injection arm 31 moves along the axial or radial direction of the bottle body 21, and then exerts a pressing force on the nozzle 22, so that the diluent in the bottle body 21 is sucked to the liquid outlet 221 and passes through the one-way valve 154 Enter the expansion bag 153 until the expansion bag 153 is full, and can no longer enter the diluent.
  • the air bag 160 is completely compressed, and the gas in the air bag 160 enters the buffer cylinder 162 through the communication tube 164, and the spring 163 is compressed.
  • the amount of liquid in the expansion bag 153 reaches the highest point.
  • the solenoid valve 155 When it is necessary to inject liquid into the structure that needs liquid injection, the solenoid valve 155 is opened, and the spring 163 recovers its deformation, pushing the gas in the buffer cylinder 162 into the air bag 160, and the air bag 160 expands Squeeze the expansion bag 153, and discharge the liquid in the expansion bag 153 through the liquid discharge pipe 152, until the spring 163 fully restores the deformation, and the expansion bag 153 is completely compressed, so that the amount of liquid injected into the structure that needs to be injected each time is The amount of liquid in the expansion bag 153 when the expansion bag 153 is fully inflated.
  • the application also discloses a detection method, comprising the following steps:
  • Step 1 pre-packaging freeze-dried reagent balls in the microfluidic disc 140;
  • Step 2 Inject the diluent into the microfluidic disk 140, specifically:
  • Use a liquid injection device provided in this application to perform liquid injection install the diluent container 20, make the liquid outlet 221 of the diluent container 20 communicate with the microfluidic disk 140; use the liquid injection arm 31 to apply pressure to the bottle body 21 , make the diluent container 20 inject liquid into the microfluidic disc 140 .
  • Step 3 using the motor 120 to drive the tray 130 and the microfluidic disc 140 placed on the tray 130 to rotate, so as to separate the samples contained in the microfluidic disc 140 and make the samples react with the reagents;
  • Step 4 Use the pre-installed light source and detector on the medical device 100 to detect the sample.
  • spatially relative terms may be used here, such as “on !, “over !, “on the surface of !, “above”, etc., to describe The spatial positional relationship between one device or feature shown and other devices or features. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, devices described as “above” or “above” other devices or configurations would then be oriented “beneath” or “above” the other devices or configurations. under other devices or configurations”. Thus, the exemplary term “above” can encompass both an orientation of “above” and “beneath”. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptions used herein interpreted accordingly.

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Abstract

一种注液装置、检测方法及医疗设备，注液装置包括安装支架（10）、稀释液容器（20）以及注液组件（30）。安装支架（10）上设置有定位部（11）；稀释液容器（20）可拆卸地设置于定位部（11），稀释液容器（20）包括瓶身（21）、喷嘴（22）以及抽吸组件，喷嘴（22）设置于瓶身（21），喷嘴（22）上设置有出液口（221），抽吸组件设置于喷嘴（22）并与瓶身（21）和出液口（221）连通，抽吸组件受喷嘴（22）施加的按压力将瓶身（21）内的稀释液抽吸至出液口（221）；注液组件（30）设置于安装支架（10），注液组件（30）包括注液臂（31），注液臂（31）沿瓶身（21）的轴向或径向运动以直接或者间接向喷嘴（22）施加按压力。注液装置使用时，只需要通过注液臂（31）的运动即可实现稀释液的添加和灌注，操作简单快捷，便于提高生化检测仪等医疗设备的检测效率。

Description

注液装置、检测方法及医疗设备 技术领域
本发明涉及医疗器械技术领域，具体而言，涉及一种注液装置、检测方法及医疗设备。
背景技术
对于检测测量液中某种特定化学成分的仪器(如生化检测仪)，由于其测量速度快、准确性高、消耗试剂量小，现已在各级医院、防疫站、计划生育服务站得到广泛使用，其可大大提高常规生化检验的效率。
近些年来，生化检测常采用微流控技术实现，用于生化检测的微流控装置内预先封装有反应材料，如冻干试剂球，在进行生化检测的过程中，需要向微流控装置内添加试剂。然而目前试剂的添加常通过人工握持移液器手持移液器，将移液器调节到要求的加液量，然后按压移液器完成抽取。该方式对操作手法有较高要求、且高精度移液器价格较高、每次抽取都要耗费一个移液枪头，操作繁琐，耗时长。
发明内容
本发明的主要目的在于提供一种注液装置、检测方法及医疗设备，以解决现有技术中的生化检测仪的稀释液添加过程操作繁琐的问题。
为了实现上述目的，第一方面，本发明提供了一种注液装置，包括：安装支架和稀释液容器，所述稀释液容器设置于所述安装支架上，所述稀释液容器包括瓶身、喷嘴以及抽吸组件，所述喷嘴设置于所述瓶身，所述喷嘴上设置有出液口，所述抽吸组件设置于所述喷嘴并与所述瓶身和所述出液口连通，所述抽吸组件受所述喷嘴施加的按压力将所述瓶身内的稀释 液抽吸至所述出液口；以及注液组件，所述注液组件设置于所述安装支架，所述注液组件包括注液臂，所述注液臂沿所述瓶身的轴向或径向运动以直接或者间接向所述喷嘴施加按压力。
进一步地，所述注液装置还包括驱动组件，所述驱动组件设置于所述安装支架，所述驱动组件与所述注液组件驱动连接以驱动所述注液臂沿所述瓶身的轴向或径向运动。
进一步地，所述注液组件还包括固定件，所述注液臂设置于所述固定件；
所述驱动组件包括驱动电机，所述驱动电机与所述固定件驱动连接以带动所述注液臂沿所述瓶身的轴向或径向运动。
进一步地，所述驱动电机为直线电机，所述固定件与所述直线电机的输出轴连接以在所述直线电机的驱动下带动所述注液臂沿所述瓶身的轴向运动；或者，所述驱动电机为旋转驱动电机，所述旋转驱动电机的输出轴与所述固定件之间通过丝杠连接，所述旋转驱动电机转动带动所述丝杠转动以驱动所述固定件及所述注液臂沿所述瓶身的轴向运动；或者，所述驱动电机为旋转驱动电机，所述旋转驱动电机的输出轴与所述固定件连接以驱动所述注液臂沿所述瓶身的径向运动。
进一步地，所述安装支架上设置有导向杆，所述导向杆穿设于所述固定件以对所述固定件进行限位和导向。
进一步地，所述安装支架上设置有定位部，所述稀释液容器可拆卸地设置于所述定位部；所述固定件沿所述瓶身的轴向运动，所述注液臂可转动地连接于所述固定件，所述注液臂具有避让所述定位部的避让位置和位 于所述定位部上方的按压位置。
进一步地，所述注液组件还包括操作把手，所述操作把手设置于所述注液臂以使所述注液臂在所述避让位置和所述按压位置之间切换。
进一步地，所述注液装置还包括控制器和位置检测元件，所述位置检测元件设置于所述安装支架以用对所述注液组件的位置进行检测，所述位置检测元件和所述驱动组件均与所述控制器电连接，所述控制器根据所述位置检测元件传递的信号对所述驱动组件进行控制。
进一步地，所述定位部为定位孔，所述稀释液容器倒立设置于所述定位孔。
第二方面，本发明的还提供了一种医疗设备，所述医疗设备包括注液装置，所述注液装置为上述的注液装置。
第三方面，本发明还提供一种检测方法，包括以下步骤：
在微流控盘片内预先封装冻干试剂球；
利用本申请第一方面所述的注液装置向微流控盘片注入稀释液；
检测。
进一步地，还包括以下步骤：
驱动微流控盘片转动，以对盛装在微流控盘片内的样本进行分离并使得样本与试剂发生反应。
进一步地，所述利用本申请第一方面所述的注液装置向微流控盘片注入试剂包括以下步骤：
安装稀释液容器，使稀释液容器的出液口与微流控盘片连通；利用注液臂对瓶身施加压力，使稀释液容器向微流控盘片注液。
应用本发明的技术方案，采用本实施例中的注液装置注液时，首先将稀释液容器安装在定位部处，并使得该稀释液容器与的出液口与需要注液的结构，例如微流控盘片连通，然后使注液臂沿瓶身的轴向或径向运动，进而对喷嘴施加按压力，就可以使得抽吸组件将瓶身内的稀释液抽吸至出液口，进而注入需要注液的结构内。可见，本发明的注液装置使用时无需人工握持和按压移液器，而只需要通过注液臂的运动即可实现稀释液的添加和灌注，操作简单快捷，便于提高生化检测仪等医疗设备的检测效率。
附图说明
构成本申请的一部分的说明书附图用来提供对本发明的进一步理解，本发明的示意性实施例及其说明用于解释本发明，并不构成对本发明的不当限定。在附图中：
图1是本发明的医疗设备的立体结构示意图；
图2是本发明的注液装置注液时的结构示意图；
图3是本发明的注液装置安装在所述医疗设备中时的结构示意图；
图4是本发明的注液装置的局部剖视图；
图5是本发明的注液装置安装缓冲机构的局部结构示意图；
图6是图5的局部结构剖视图。
其中，上述附图包括以下附图标记：
10、安装支架；11、定位部；20、稀释液容器；21、瓶身；22、喷嘴；221、出液口；30、注液组件；31、注液臂；311、操作把手；312、连接销；32、固定件；40、驱动组件；50、导向杆；60、位置检测元件；100、医疗设备；110、基座；120、电机；130、托盘；140、微流控盘片；150、出液 管；151、缓冲器；152、排液管；153、膨胀袋；154、单向阀；155、电磁阀；160、气囊；161、活塞；162、缓冲筒；163、弹簧；164、连通管；165、泄压口。
具体实施方式
参见图1至图3所示，根据本发明的实施例，提供了一种医疗设备100，本实施例中的医疗设备100尤其是指生化检测仪或者发光检测仪等医疗设备100。具体来说，本实施例中的医疗设备100包括基座110和设置于基座110上方的注液装置。
其中，基座110上设置有托盘130，该托盘130可以在电机120的驱动下转动，托盘130用于放置微流控盘片140。实际使用时，将微流控盘片140放置于托盘130上，然后向微流控盘片140内注入待检测样品，再利用注液装置向微流控盘片140添加稀释液，就可以对预先封装在微流控盘片140内的冻干试剂球进行稀释，接着利用电机120驱动托盘130以及放置于托盘130上的微流控盘片140转动，即可以对盛装在微流控盘片140内的样品进行分离并使得样品与试剂发生反应，最后再利用医疗设备100上预先安装的光源以及探测器等对样品进行检测即可。
正如背景技术中所描述的那样，现有的生化检测仪等医疗设备100上未设置注液装置，通常都是采用人工手动向微流控盘片140添加稀释液的，此过程中需要人工握持移液器。
因此本申请还公开一种注液装置。
下面将结合附图对本实施例中的注液装置的具体结构进行详细介绍。
参见图2至图4所示，本实施例中的注液装置包括安装支架10、稀释 液容器20以及注液组件30。
其中，安装支架10设置于基座110的上方，且该安装支架10具有定位部11，该定位部11用于对稀释液容器20进行定位；稀释液容器20可拆卸地设置于定位部11，如此，便于对稀释液容器20进行更换；该稀释液容器20包括瓶身21、喷嘴22以及抽吸组件(图中未示出)，喷嘴22设置于瓶身21，该喷嘴22上设置有出液口221，实际安装时，该出液口221与微流控盘片140上的注液口连通(参见图2所示)，抽吸组件设置于喷嘴22并与瓶身21和出液口221连通，工作时，该抽吸组件受喷嘴22施加的按压力将瓶身21内的稀释液抽吸至出液口221(如压泵瓶原理)，进而可以将稀释液输送至微流控盘片140；
注液组件30设置于安装支架10上，该注液组件30包括注液臂31，该注液臂31沿瓶身21的轴向或径向运动以直接或者间接向喷嘴22施加按压力。
可以理解的是，这里所述的注液臂31沿瓶身21的轴向或径向运动以直接或者间接向喷嘴22施加按压力是指：使注液臂31沿瓶身21的高度方向运动直接向喷嘴22施加按压力(例如使注液臂31沿瓶身21的高度方向上下运动按压喷嘴22)，或者，使注液臂31沿瓶身21的高度方向运动间接向喷嘴22施加按压力(例如使注液臂31沿瓶身21的高度方向上下运动按压瓶身21进而按压喷嘴22)，或者，使注液臂31沿瓶身21的径向运动直接向喷嘴22施加按压力(例如使注液臂31沿瓶身21的径向运动按压喷嘴22，此时，可以在喷嘴22上设置楔形面与注液臂31配合)，或者，使注液臂31沿瓶身21的径向运动间接向喷嘴22施加按压力(例如使注液 臂31沿瓶身21的径向运动按压瓶身21进而按压喷嘴22，此时，可以在瓶身21上设置楔形面与注液臂31配合)。
采用本实施例中的注液装置注液时，首先将稀释液容器20安装在定位部11处，并使得该稀释液容器20的出液口221与需要注液的结构(例如微流控盘片140)连通，然后使注液臂31沿瓶身21的轴向或径向运动，进而对喷嘴22施加按压力，就可以使得抽吸组件将瓶身21内的稀释液抽吸至出液口221，进而注入需要注液的结构内。可见，本发明的注液装置使用时无需人工握持和按压移液器，而只需要通过注液臂31的运动即可实现稀释液的添加和灌注，操作简单快捷，便于提高生化检测仪等医疗设备100的检测效率。
进一步地，本实施例中的安装支架10为一个架体，只要是便于对稀释液容器20以及注液组件30等进行安装的架体结构即可，本实施例中不作具体限定。
在本实施例中的一种可选的实施方式中，将定位部11设置为定位孔，此时，稀释液容器20倒立(即喷嘴22向下，瓶身21向上的安装方式)设置于定位孔，实际使用时，只需要利用注液臂31对稀释液容器20进行按压，即可实现稀释液容器20的下喷。如果使该稀释液容器20的出液口221与需要注液的结构对准，就无需在出液口221与需要注液的结构之间设置连接管道，能够简化医疗设备100的结构，且稀释液的传输路径更短，更适于使用在精准检测仪器上。
当然，在本发明的其他实施方式中，稀释液容器20还可以正立或者倾斜安装于安装支架10上，此时，则需要在喷嘴22与需要注液的结构之间 设置连接管道，只要是在本发明的构思下的其他变形方式，均在本发明的保护范围之内。
再次参见图2至图4所示，本实施例中的注液装置还设置有驱动组件40，该驱动组件40设置于安装支架10，通过设置驱动组件40，可以驱动注液臂31沿瓶身21轴向或者径向运动，如此，可以对稀释液容器20进行按压，进而可以将稀释液容器20内部的稀释液抽吸至出液口221，进而添加至需要注液的结构内，整个注液过程无需医务人员对稀释液容器20进行按压，自动化程度，省时省力，能够进一步提高生化检测仪等医疗设备100的检测效率。
为了对注液臂31进行安装，本实施例中的注液组件30还包括固定件32，该固定件32例如可以是一块固定块，实际安装时，将注液臂31设置于该固定件32；驱动组件40包括驱动电机，该驱动电机与固定件32驱动连接，从而可以带动注液臂31沿瓶身21的轴向或径向运动，结构稳定可靠。
在本发明的一种实施方式中，将驱动电机设置为直线电机，组装时，固定件32与直线电机的输出轴连接以在直线电机的驱动下带动注液臂31沿瓶身21的轴向运动，此时，注液臂31沿瓶身21的轴向进行往复运动，可以对喷嘴22进行按压以将瓶身21内的稀释液抽出。
在本发明的另一种未示出的实施方式中，还可以将驱动电机设置为旋转驱动电机，该旋转驱动电机的输出轴与固定件32之间通过丝杠连接，该旋转驱动电机转动带动丝杠转动以驱动固定件32及注液臂31沿瓶身21的轴向运动，此时，注液臂31沿瓶身21的轴向进行往复运动，可以对喷嘴 22进行按压以将瓶身21内的稀释液抽出。
在本发明的另一种未示出的实施方式中，还可以将驱动电机设置为旋转驱动电机，该旋转驱动电机的输出轴与固定件32连接以驱动注液臂31沿瓶身21的径向运动，此时，稀释液容器20上设置有一楔形面，注液臂31与该楔形面配合，当驱动电机带动注液臂31沿瓶身21的径向运动时，该注液臂31沿楔形面运动，可以对稀释液容器20进行按压，进而可以将瓶身21内的稀释液抽吸出来以向需要注液的结构进行灌注。
进一步地，本实施例中的安装支架10上设置有导向杆50，该导向杆50穿设于固定件32以对固定件32进行限位和导向。当驱动组件40工作时，该导向杆50可以对固定件32进行限位和导向，整个结构更加稳定可靠。可选地，本实施例中的导向杆50可以是圆柱形杆，还可以是棱柱杆，只要是在本发明的构思下的其他变形方式，均在本发明的保护范围之内。
在本发明的一种实施方式中，驱动组件40驱动固定件32沿瓶身21的轴向运动，在这种结构中，固定件32处于稀释液容器20的上方，当稀释液容器20内的稀释液用完之后，不便于对稀释液容器20进行更换。为此，本实施例中将注液臂31可转动地连接于固定件32，实际使用时，该注液臂31具有避让定位部11的避让位置和位于定位部11上方的按压位置。需要更换稀释液容器20时，只需要将注液臂31旋转至避让位置即可。
具体地，本实施例中的注液臂31通过连接销312连接在固定件32上，该注液臂31可以相对连接销312转动以便于在避让位置和按压位置之间切换，结构简单，便于实现。
进一步地，本实施例中的注液组件30还包括操作把手311，该操作把 手311设置于注液臂31上，使用时，握持操作把手311即可以使注液臂31在避让位置和按压位置之间切换，结构简单，便于操作。可选地，本实施例中的注液臂31为一长条臂，该注液臂31的一端通过上述的连接销312与固定件32连接，操作把手311设置于注液臂31的另一端，通过操作把手311带动注液臂31转动时更加省力，操作更加简单快捷。
进一步地，本实施例中的注液装置还包括控制器(图中未示出)和位置检测元件60，该位置检测元件60设置于安装支架10以用对注液组件30的位置进行检测，位置检测元件60和驱动组件40均与控制器电连接，控制器根据位置检测元件60的传递的信号对驱动组件40进行控制。具体而言，本实施例中的位置检测元件60可以是光电开关、位置传感器等结构，该位置检测元件60设置在安装支架10上，具体设置于安装支架10与注液组件30相对应的部位，当位置检测元件60检测到注液组件30移动到初始位置时，控制器可以根据控制需要控制驱动组件40带动注液组件30执行按压注液动作，当该位置检测元件60检测到注液组件30位移动到初始位置时，控制器控制驱动组件40运动直至位置检测元件60向控制器传递注液组件30回归至初始位置。也即，本实施例中设置控制器以及位置检测元件60，便于提高本发明的注液装置的自动化程度，能够进一步提高本发明的医疗设备100的工作效率。
综上所述，通过本发明中的注液装置注液时，首先将稀释液容器20安装在定位部11处，并使得该稀释液容器20的出液口221与需要注液的结构(例如微流控盘片140)连通，然后使注液臂31沿瓶身21的轴向或径向运动，进而对喷嘴22施加按压力，就可以使得抽吸组件将瓶身21内的稀 释液抽吸至出液口221，进而注入需要注液的结构内。可见，本发明的注液装置使用时无需人工握持和按压移液器，而只需要通过注液臂31的运动即可实现稀释液的添加和灌注，操作简单快捷，便于提高生化检测仪等医疗设备100的检测效率。
在本发明的另一实施方式中，参照图5和图6，为了使每次能等量的向需要注液的结构内注液，在喷嘴22上安装有缓冲机构，缓冲机构包括出液管150、缓冲器151和排液管152，出液管150固定在喷嘴22上，出液管150呈竖直设置，出液管150和出液口221连通，缓冲器151固定在出液管150远离出液口221的一端，缓冲器151呈球形，且缓冲器151为刚性材质，缓冲器151为中空设置，出液管150下端伸入缓冲器151中，排液管152固定在缓冲器151与出液管150相对的一端，排液管152呈竖直设置，排液管152上端延伸至缓冲器151中，缓冲器151内放置有膨胀袋153，膨胀袋153为软袋，膨胀袋153可膨胀和压缩，出液管150和排液管152延伸至缓冲器151的一端均连通膨胀袋153，出液管150上安装有单向阀154，单向阀154用于使喷嘴22中的液体流向膨胀袋153，排液管152上安装有电磁阀155，通过电力控制电磁阀155的开启；
缓冲器151内固定连接有气囊160，气囊160包覆于膨胀袋153。
在安装支架10上固定连接有缓冲筒162，缓冲筒162呈卧式，缓冲筒162内可移动连接有活塞161，活塞161外壁和缓冲筒162内壁相适配，且活塞161和缓冲筒162之间为密封设置，缓冲筒162上连通有连通管164，连通管164连通气囊160，缓冲筒162内沿活塞161移动方向固定连接有弹簧163，弹簧163和活塞161固定连接，弹簧163位于活塞161远离连 通管164的一侧；弹簧163未形变时，气囊160膨胀以使膨胀袋153完全被压缩；另外在缓冲筒162靠近弹簧163的一侧开设有泄压口165。
使用时，通过注液臂31沿瓶身21的轴向或径向运动，进而对喷嘴22施加按压力，使瓶身21内的稀释液抽吸至出液口221，并经过单向阀154进入到膨胀袋153中，直至膨胀袋153充满，无法再进入稀释液，此时气囊160被完全压缩，气囊160中的气体通过连通管164进入到缓冲筒162中，弹簧163被压缩，此时膨胀袋153中的液体量达到最高点，当需要对需要注液的结构内注液时，开启电磁阀155，弹簧163恢复形变，将缓冲筒162内的气体推至气囊160中，气囊160膨胀挤压膨胀袋153，将膨胀袋153中的液体通过排液管152排出，直至弹簧163完全恢复形变，膨胀袋153被完全压缩，从而每次向需要注液的结构内注入的液体量均为膨胀袋153完全膨胀时膨胀袋153内的液体量。
本申请还公开一种检测方法，包括如下步骤：
步骤1、在微流控盘片140内预先封装冻干试剂球；
步骤2、向微流控盘片140注入稀释液，具体为：
利用本申请所提供的一种注液装置进行注液：安装稀释液容器20，使稀释液容器20的出液口221与微流控盘片140连通；利用注液臂31对瓶身21施加压力，使稀释液容器20向微流控盘片140注液。
步骤3、利用电机120驱动托盘130以及放置于托盘130上的微流控盘片140转动，以对盛装在微流控盘片140内的样本进行分离并使得样本与试剂发生反应；
步骤4、利用医疗设备100上预先安装的光源以及探测器等对样品进 行检测。
为了便于描述，在这里可以使用空间相对术语，如“在……之上”、“在……上方”、“在……上表面”、“上面的”等，用来描述如在图中所示的一个器件或特征与其他器件或特征的空间位置关系。应当理解的是，空间相对术语旨在包含除了器件在图中所描述的方位之外的在使用或操作中的不同方位。例如，如果附图中的器件被倒置，则描述为“在其他器件或构造上方”或“在其他器件或构造之上”的器件之后将被定位为“在其他器件或构造下方”或“在其他器件或构造之下”。因而，示例性术语“在……上方”可以包括“在……上方”和“在……下方”两种方位。该器件也可以其他不同方式定位(旋转90度或处于其他方位)，并且对这里所使用的空间相对描述作出相应解释。
此外，需要说明的是，使用“第一”、“第二”等词语来限定零部件，仅仅是为了便于对相应零部件进行区别，如没有另行声明，上述词语并没有特殊含义，因此不能理解为对本发明保护范围的限制。
以上所述仅为本发明的优选实施例而已，并不用于限制本发明，对于本领域的技术人员来说，本发明可以有各种更改和变化。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (10)

  1. 一种注液装置，其特征在于，包括：安装支架(10)和稀释液容器(20)，所述稀释液容器(20)设置于所述安装支架(10)上，所述稀释液容器(20)包括瓶身(21)、喷嘴(22)以及抽吸组件，所述喷嘴(22)设置于所述瓶身(21)，所述喷嘴(22)上设置有出液口(221)，所述抽吸组件设置于所述喷嘴(22)并与所述瓶身(21)和所述出液口(221)连通，所述抽吸组件受所述喷嘴(22)施加的按压力将所述瓶身(21)内的稀释液抽吸至所述出液口(221)；以及注液组件(30)，所述注液组件(30)设置于所述安装支架(10)，所述注液组件(30)包括注液臂(31)，所述注液臂(31)沿所述瓶身(21)的轴向或径向运动以直接或者间接向所述喷嘴(22)施加按压力。
  2. 根据权利要求1所述的注液装置，其特征在于，所述注液装置还包括驱动组件(40)，所述驱动组件(40)设置于所述安装支架(10)，所述驱动组件(40)与所述注液组件(30)驱动连接以驱动所述注液臂(31)沿所述瓶身(21)的轴向或径向运动。
  3. 根据权利要求2所述的注液装置，其特征在于，所述安装支架(10)上设置有定位部(11)，所述稀释液容器(20)可拆卸地设置于所述定位部(11)；所述注液组件(30)还包括固定件(32)，所述固定件(32)沿所述瓶身(21)的轴向运动，所述注液臂(31)可转动地连接于所述固定件(32)，所述注液臂(31)具有避让所述定位部(11)的避让位置和位于所述定位部(11)上方的按压位置。
  4. 根据权利要求3所述的注液装置，其特征在于，所述注液组件(30)还包括操作把手(311)，所述操作把手(311)设置于所述注液臂(31) 以使所述注液臂(31)在所述避让位置和所述按压位置之间切换。
  5. 根据权利要求2至4中任一项所述的注液装置，其特征在于，所述注液装置还包括控制器和位置检测元件(60)，所述位置检测元件(60)设置于所述安装支架(10)以用对所述注液组件(30)的位置进行检测，所述位置检测元件(60)和所述驱动组件(40)均与所述控制器电连接，所述控制器根据所述位置检测元件(60)传递的信号对所述驱动组件(40)进行控制。
  6. 根据权利要求1至4中任一项所述的注液装置，其特征在于，所述喷嘴(22)上设有和出液口(221)连通的出液管(150)，所述出液管(150)上安装有缓冲器(151)，所述缓冲器(151)为中空设置，所述出液管(150)延伸至缓冲器(151)中，所述缓冲器(151)上安装有延伸至缓冲器(151)内的排液管(152)，所述缓冲器(151)内设有膨胀袋(153)，所述出液管(150)和所述排液管(152)均连通所述膨胀袋(153)，所述缓冲器(151)内设有包覆于所述膨胀袋(153)的气囊(160)，所述安装支架(10)上固定连接有缓冲筒(162)，所述缓冲筒(162)内可移动连接有活塞(161)，所述缓冲筒(162)连通所述气囊(160)，所述缓冲筒(162)内设有用于驱使所述活塞(161)移动以对所述气囊(160)充气的弹簧(163)；所述出液管(150)上安装有用于使喷嘴(22)中的液体流向所述膨胀袋(153)的单向阀(154)，所述排液管(152)上安装有电磁阀(155)。
  7. 一种医疗设备，其特征在于，所述医疗设备包括注液装置，所述注液装置为权利要求1至6中任一项所述的注液装置。
  8. 一种检测方法，其特征在于，包括以下步骤：
    在微流控盘片(140)内预先封装冻干试剂球；
    利用权利要求1-7任意一项所述的注液装置向微流控盘片(140)注入稀释液；
    检测。
  9. 根据权利要求8所述的一种检测方法，其特征在于，还包括以下步骤：
    驱动微流控盘片(140)转动，以对盛装在微流控盘片(140)内的样本进行分离并使得样本与试剂发生反应。
  10. 根据权利要求8所述的一种检测方法，其特征在于，所述利用权利要求1-7任意一项所述的注液装置向微流控盘片(140)注入稀释液包括以下步骤：
    安装稀释液容器(20)，使稀释液容器(20)的出液口(221)与微流控盘片(140)连通；利用注液臂(31)对瓶身(21)施加压力，使稀释液容器(20)向微流控盘片(140)注液。
PCT/CN2023/071328 2022-01-29 2023-01-09 注液装置、检测方法及医疗设备 WO2023143004A1 (zh)

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