WO2023026624A1 - 自動分析装置、および自動分析装置用給水タンク - Google Patents

自動分析装置、および自動分析装置用給水タンク Download PDF

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Publication number
WO2023026624A1
WO2023026624A1 PCT/JP2022/022295 JP2022022295W WO2023026624A1 WO 2023026624 A1 WO2023026624 A1 WO 2023026624A1 JP 2022022295 W JP2022022295 W JP 2022022295W WO 2023026624 A1 WO2023026624 A1 WO 2023026624A1
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WIPO (PCT)
Prior art keywords
water supply
supply tank
automatic analyzer
water
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2022/022295
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English (en)
French (fr)
Japanese (ja)
Inventor
由規 村松
洋行 高山
孝宏 熊谷
弥悠 小黒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi High Tech Corp
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Hitachi High Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi High Tech Corp filed Critical Hitachi High Tech Corp
Priority to US18/684,030 priority Critical patent/US20240425350A1/en
Priority to CN202280050702.3A priority patent/CN117716242A/zh
Priority to JP2023543698A priority patent/JP7696435B2/ja
Priority to EP22859556.7A priority patent/EP4393609A4/en
Publication of WO2023026624A1 publication Critical patent/WO2023026624A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67D—DISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISE PROVIDED FOR
    • B67D7/00—Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes
    • B67D7/06—Details or accessories
    • B67D7/58—Arrangements of pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67D—DISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISE PROVIDED FOR
    • B67D7/00—Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes
    • B67D7/02—Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
    • B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027—Cleaning the internal surfaces; Removal of blockages
    • B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
    • B08B9/0321—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing using pressurised, pulsating or purging fluid
    • B08B9/0323—Arrangements specially designed for simultaneous and parallel cleaning of a plurality of conduits

Definitions

  • the present invention relates to an automatic analyzer and a water supply tank for the automatic analyzer.
  • Patent Document 1 discloses a self-controlled pressure reduction system between an electric pressure pump and a branch pipe.
  • a direct-acting solenoid valve and a fixed resistance pipe with a specific hole diameter and length are installed in the pipe from the branch pipe, and water is supplied instantly by opening and closing the solenoid valve.
  • An automated analyzer reacts a biological sample such as blood with an analytical reagent that specifically reacts with the component to be measured in the sample, and analyzes the complex produced by this reaction using spectroscopic techniques such as electrochemiluminescence. It refers to a device that detects by a method, and automatically performs everything from detection of the measurement target component to output of the result.
  • a biochemical automatic analyzer which is an example of an automatic analyzer, analyzes the components of biological samples such as serum and urine.
  • a sample and a reagent are generally dispensed into reaction vessels using a dispensing probe and allowed to react. Measured optically by the unit.
  • contamination of the probe affects the accuracy of dispensing and, as a result, affects the reliability of the automatic analyzer. Therefore, after the sample or the like is dispensed, the sample or the like adhering to the outer surface or the inner surface of the probe is washed with a washing liquid in a washing tank.
  • the automatic biochemical analyzer uses pure water for the dispensing and washing. Pure water is produced in a pure water production apparatus separated from the main body as described in the above-mentioned Patent Document 1, and even if the water to be supplied contains air bubbles, they are prevented from entering the inside of the apparatus. A water tank (water tank) large enough to stabilize the water flow is provided as a buffer for temporary storage.
  • the present invention has been made in view of the above problems, and is a highly reliable automatic analyzer that can suppress the frequency of stains and bacteria that occur on the inner surface of the water tank and reduce the frequency of cleaning the water tank. , and to provide a water tank for automatic analyzers.
  • the present invention includes a plurality of means for solving the above problems.
  • a liquid supplied from the outside of the apparatus and consumed by each mechanism of the automatic analyzer is a water tank for temporarily storing water; a supply channel connected from the water tank to each mechanism of the automatic analyzer; a pump for feeding the liquid in the water tank; a circulation flow path for returning liquid to the water supply tank, the water supply tank having an upwardly sloping bottom surface along with forming a swirling flow within the water supply tank by the liquid from the circulation flow path.
  • FIG. 1 is an overall configuration diagram of an automatic analyzer according to an embodiment of the present invention
  • FIG. Sectional drawing seen from the horizontal direction of a general water supply tank seen from the horizontal direction of a general water supply tank.
  • FIG. 4 is a perspective view of the bottom surface of the water supply tank in the automatic analyzer according to the present embodiment
  • FIG. 5 is a cross-sectional view along line ABC in FIG. 5 of the bottom surface of the water supply tank in the automatic analyzer according to the present embodiment.
  • FIG. 2 is a top view of the water supply tank in the automatic analyzer according to the present embodiment.
  • FIG. 2 is a cross-sectional view of the water supply tank in the automatic analyzer according to the present embodiment;
  • FIG. 4 Sectional drawing seen from the horizontal direction of a general water supply tank.
  • FIG. 4 is a perspective view of the bottom surface of the water supply tank in the automatic analyzer according to the present embodiment
  • FIG. 5 is a cross-sectional view along line ABC in FIG. 5 of the bottom surface of the water
  • FIG. 4 is a diagram showing details of internal shapes of a refilling port, a supply port, and a return water inlet in the automatic analyzer according to the present embodiment
  • FIG. 4 is a diagram showing details of internal shapes of a refilling port, a supply port, and a return water inlet in the automatic analyzer according to the present embodiment
  • FIG. 1 An embodiment of the automatic analyzer and the water tank for the automatic analyzer of the present invention will be described with reference to FIGS. 1 to 8.
  • FIG. 1 the same or corresponding components are denoted by the same or similar reference numerals, and repeated descriptions of these components may be omitted.
  • FIG. 1 is a diagram schematically showing the overall configuration of an automatic analyzer 100 of the present invention.
  • the automatic analyzer 100 shown in FIG. 1 mainly includes an analysis unit 101 configured to mix and react a sample such as blood with a reagent and measure the absorbance of the reaction liquid, and each mechanism of the analysis unit 101. It is divided into three areas: a portion of the water supply unit 102 which is a mechanism for supplying pure water to the , and the controller 25 .
  • the analysis unit 101 is a mechanism for dispensing a sample and a reagent into a plurality of reaction containers 2 and allowing them to react, and measuring the reacted liquid.
  • reaction disk 1 On the reaction disk 1, a plurality of reaction vessels 2 for mixing and reacting samples and reagents are arranged on the circumference.
  • a sample transport mechanism 17 for moving a sample rack 16 carrying a sample container 15 containing a sample such as blood is installed near the reaction disk 1 (reaction chamber).
  • Rotatable and vertically movable sample dispensing mechanisms 11 and 12 are installed between the reaction disk 1 and the sample transport mechanism 17, and are provided with sample probes 11a and 12a, respectively.
  • a sample syringe 18 is connected to the sample probes 11a and 12a. The sample probes 11 a and 12 a move in an arc around the rotating shaft, and the sample is dispensed from the sample vessel 15 transported to the sample dispensing position by the sample transport mechanism 17 to the reaction vessel 2 .
  • a washing tank 13 for washing the sample probe 11a with washing water and a washing container (not shown for convenience of illustration) for washing with special washing water are arranged in the operating range of the sample dispensing mechanism 11.
  • a washing tank 14 for washing the sample probe 12a with washing water and a washing container (not shown) for washing with special washing water are arranged in the operating range of the sample pipetting mechanism 12 .
  • the reagent disk 9 has a structure in which a plurality of reagent bottles 10 can be mounted on the circumference.
  • the reagent disk 9 is kept cool and covered with a cover provided with a suction port (not shown).
  • the reagent bottle 10 is a bottle containing reagents used for sample analysis.
  • reagent dispensing mechanisms 7 and 8 are installed, each equipped with reagent probes 7a and 8a.
  • a reagent syringe 19 is connected to the reagent probes 7a and 8a.
  • the reagent probes 7a and 8a move in an arc around the rotation axis, access the inside of the reagent disk 9 through the suction port, and dispense the reagent from the reagent bottle 10 to the reaction container 2.
  • a washing tank 32 for washing the reagent probe 7a with washing water is arranged in the operating range of the reagent dispensing mechanism 7, and a washing tank 33 for washing the reagent probe 8a with washing water is arranged in the operating range of the reagent dispensing mechanism 8. It is
  • stirring mechanisms 5 and 6 Surrounding the reaction disk 1 are stirring mechanisms 5 and 6 for stirring the mixture (reaction liquid) of the sample and the reagent dispensed into the reaction vessel 2, A spectrophotometer 4 for measuring the absorbance of the reaction solution by measuring transmitted light, a cleaning mechanism 3 for cleaning the used reaction vessel 2, and the like are arranged.
  • the stirring mechanisms 5 and 6 are configured to be capable of horizontal rotation and vertical movement, and are inserted into the reaction container 2 to stir the mixed solution (reaction solution) of the sample and the reagent.
  • Cleaning tanks 30 and 31 for cleaning the stirring mechanisms 5 and 6 with cleaning water are arranged in the operation range of the stirring mechanisms 5 and 6 .
  • a cleaning pump is connected to the cleaning mechanism 3 .
  • the controller 25 is connected to the devices in the automatic analyzer 100 described above, and controls the operation of each device/mechanism in the automatic analyzer 100 .
  • the controller 25 is a computer having a CPU, a memory, etc., and performs arithmetic processing to obtain the concentration of a predetermined component in the sample from the detection result of the spectrophotometer 4 .
  • the control of the operation of each device by the controller 25 is executed based on various programs recorded in the storage device.
  • the storage device stores various parameters input via the input device, information on the sample to be measured (sample type information, etc.), measurement results, and the like.
  • the operation control processing executed by the controller 25 may be integrated into one program, may be divided into a plurality of programs, or may be a combination thereof. Also, part or all of the program may be realized by dedicated hardware, or may be modularized.
  • the display unit 25a is a display device such as a liquid crystal display that displays to the operator various information in the automatic analyzer 100, such as input screens for various parameters and settings, analytical test data of the first test or retest, measurement results, and reagent information. is.
  • a touch panel type that also serves as an input unit can be used.
  • the water supply unit 102 has a function of supplying pure water to the analysis unit 101, and includes a pure water facility 50, a water supply electromagnetic valve 51, a water level sensor 52, a water supply tank 53, a water supply pump 54, a fixed throttle 55, and the like. there is
  • the pure water facility 50 is a facility for supplying pure water from the outside of the automatic analyzer 100 to the water supply tank 53 inside the automatic analyzer 100, and is equipment of facilities such as hospitals and examination centers where the automatic analyzer 100 is installed. be.
  • the water supply tank 53 temporarily stores the liquid consumed by each mechanism of the automatic analyzer 100 .
  • Pure water is not always supplied to the water supply tank 53, and in order to supply pure water to the water supply tank when necessary, a water supply electromagnetic valve 51 is installed in the piping from the pure water facility 50 to the water supply tank 53. is provided.
  • the water supply tank 53 is equipped with a laser water level sensor 71 to prevent the pure water stored in the water supply tank 53 from overflowing or depleting.
  • the water supply electromagnetic valve 51 described above is controlled to open and close based on the water level information from the laser type water level sensor 71 .
  • the water supply pump 54 supplies pure water from the water supply tank 53 to each mechanism of the analysis unit 101 through the supply channel 64 .
  • the controller 25 opens any one or more of the electromagnetic valves 3a, 18a, 19a, 30a, 31a, 32a, 33a, 40a, and 42a provided before the point where the pure water is consumed to supply water.
  • pure water is circulated to the water supply tank 53 from the circulation channel 65 provided with the fixed throttle 55 .
  • the configuration of the automatic analyzer 100 is not limited to the biochemical analyzer that executes analysis of biochemical analysis items as shown in FIG. It can be an analysis device that executes analysis of analysis items of. Also, the biochemical analysis apparatus is not limited to the form shown in FIG. 1, and may be one in which an analysis device for measuring other analysis items, such as electrolytes, is separately mounted.
  • the automatic analyzer 100 is not limited to the single analysis module configuration as shown in FIG. can be configured to connect two or more.
  • the analytical processing of the test sample by the automatic analyzer 100 as described above is generally executed in the following order.
  • the sample in the sample container 15 placed on the sample rack 16 transported to the vicinity of the reaction disk 1 by the sample transport mechanism 17 is transferred to the reaction disk 1 by the sample probes 11a and 12a of the sample dispensing mechanisms 11 and 12. Dispense into reaction vessel 2 above.
  • a reagent to be used for analysis is dispensed from the reagent bottle 10 on the reagent disk 9 to the reaction container 2 into which the sample was previously dispensed by the reagent dispensing mechanisms 7 and 8 .
  • the mixture of the sample and the reagent in the reaction container 2 is stirred by the stirring mechanisms 5 and 6 .
  • the light generated from the light source 4 a is transmitted through the reaction vessel 2 containing the mixed liquid after stirring, and the luminous intensity of the transmitted light is measured by the spectrophotometer 4 .
  • the light intensity measured by the spectrophotometer 4 is transmitted to the controller 25 via the A/D converter and interface. Then, the controller 25 performs calculations to determine the concentration of a predetermined component in a liquid sample such as blood or urine, and the results are displayed on the display unit 25a or the like and stored in a storage unit (not shown).
  • the main places where pure water is used in the apparatus are the circulating water for keeping the temperature of the reaction disk 1, the circulating water for keeping the reagent disk 9 cool, and the washing water for the reagent probes 7a and 8a and the sample probes 11a and 12a. .
  • reaction disk 1 pure water maintained at a constant temperature (eg, 37 degrees) is circulated by a circulation pump 40 in order to react the sample and the reagent at a constant temperature.
  • the pure water is used to keep the reaction vessel 2 at a constant temperature, and the sample and the reagent are reacted under constant conditions.
  • the light generated from the light source 4a penetrates not only the reaction vessel 2 but also the pure water flowing through the reaction vessel.
  • a degassing device (not shown) is provided in the flow path for circulating the reaction tank to prevent the generation of air bubbles inside the reaction tank.
  • the inside of the reagent disk 9 is kept at a low temperature by circulating the pure water cooled by the cooling machine with the circulation pump 42 in order to prevent deterioration of the reagent.
  • the reagent probes 7a and 8a used for reagent aspiration and dispensing and the sample probes 11a and 12a used for sample aspiration and dispensing are not disposable, and the same probes are used continuously.
  • the outer surfaces of the reagent probes 7a and 8a are generally washed in the washing tanks 32 and 33, and the outer surfaces of the sample probes 11a and 12a are washed. are cleaned by discharging cleaning water toward the outer surface of the probe in cleaning tanks 13 and 14 .
  • the inner surfaces of the probes are cleaned by discharging cleaning water pressurized by pumps from the cleaning tanks 13, 14, 31, and 32 from the probes.
  • a gear pump 41 is often used to pressurize the washing water.
  • pure water is used in various mechanisms of the analysis unit 101. Therefore, if air bubbles are mixed into the supplied pure water, it may cause a decrease in analysis performance or a failure of the apparatus. provided to implement it.
  • a typical water tank shape will be described with reference to FIG. FIG. 2 shows a conventional water supply pump structure.
  • FIG. 2 is a cross-sectional view of a general water supply tank 553 viewed from the horizontal direction.
  • the water supply tank 553 includes a water supply port 561 from the pure water facility 50 , a supply port 562 to the water supply pump 54 , and a return water inlet 563 from the water supply pump 54 .
  • a float type water level sensor 552 , a refilling port 561 , and a return water inlet 563 are fixed to a cap 564 and installed in a water supply tank 553 . When the cap 564 and the water supply tank 53 are installed, they are not fixed, and have a structure in which air is released from the gap.
  • the pure water outlets (exit 561a on the replenishing water inlet 561 side and outlet 563a on the return water inlet 563 side) are set at a height equal to or lower than the float type water level sensor 552 .
  • the water supply tank 553 is large enough to stabilize the water flow in the tank so that even if air bubbles are mixed in the supplied pure water, it will not be supplied from the supply port 562 to the water supply pump 54 .
  • the supply port 562 to the analysis unit side, the outlet 561a of the refilling port 561 from the pure water facility 50, and the outlet 563a of the return water inlet 563 are installed at sufficiently distant positions.
  • the water flow in the water supply tank 553 is stabilized.
  • water remains in the water supply tank 553 for a long time, and various germs are easily propagated, so that dirt may accumulate on the inner surface of the water supply tank 553 .
  • the dirty water supplied to the analysis unit 101 via the water supply pump 54 may affect the analysis performance.
  • FIG. 3 is a perspective view of the bottom surface of the water supply tank
  • FIG. 4 is a cross section along line ABC shown in FIG. 5 of the bottom surface of the water supply tank
  • FIG. 5 is a top view of the water supply tank
  • FIGS. 7 and 8 are diagrams showing the details of the internal shapes of the refilling port, the supply port, and the return water inlet.
  • the water supply tank 53 has a cylindrical shape at least on the bottom surface 301 side.
  • a water supply port 201 for supplying liquid from the pure water facility 50 to the water supply tank 53 is provided at the center of the bottom surface 301 .
  • a supply port 202 that connects the water supply tank 53 and the supply channel 64 and a return water inlet 203 that connects the water supply tank 53 and the circulation channel 65 are also provided on the bottom surface 301 .
  • the refilling port 201 , the supply port 202 , and the return water inlet 203 are vertically opened from the bottom surface 301 .
  • half of the bottom surface 301 of the water supply tank 53 has an upward slope so that the circulating pure water returning to the water supply tank 53 from the circulation flow path 65 forms a swirling flow within the water supply tank 53 .
  • the bottom surface 301 may be entirely sloped upward, and is not particularly limited.
  • a cover 205 is provided that covers the return water inlet 203 and changes the flow direction of the circulating water supplied from the return water inlet 203 to the vertical and horizontal directions. Further, the opening of the cover 205 opens to the circumferential direction side of the bottom portion of the substantially cylindrical water supply tank 53 .
  • the pure water returning from the circulation flow path 65 to the water supply tank 53 collides with the cover 205 and changes its direction in a horizontal direction substantially parallel to the bottom surface 301 of the water supply tank 53 to flow. Then, the flowing pure water forms a spiral water flow along the upward slope bottom surface 301 and the substantially cylindrical side surface. Therefore, the bottom surface 301 inside the water supply tank 53 is less likely to have a portion where water stagnates, and dirt such as germs is less likely to accumulate.
  • the supply port 202 is formed at a position lower in the vertical direction than the outlet 201 a of the refilling port 201 and the return water inlet 203 .
  • the recess 301a of the bottom surface 301 is provided. This prevents air having a small mass from being supplied to the water supply pump 54 .
  • the water flow in the water supply tank 53 is a slightly upward flow along the bottom surface 301 with an upward slope. Air bubbles are designed to escape to the upper part of the water supply tank 53 .
  • the positional relationship in the height direction between the outlet 201a of the refilling port 201 and the return water inlet 203 is not particularly defined, but the pure water that once passed through the supply port 202 located on the lowest surface returns. Since the return water inlet 203 is unlikely to contain air bubbles and there is a concern that pure water with a high possibility of containing air bubbles may be discharged from the pure water facility 50 side, as shown in FIG. , it is desirable to position the replenishing water port 201 higher than the return water inlet 203 in the vertical direction.
  • the water level of the water supply tank 53 can be monitored by the float type water level sensor 552, but by monitoring the water level from the outside of the water supply tank 53, it is possible to reduce the number of objects in contact with the pure water, thereby locating areas where dirt accumulates and cleaning areas. External monitoring is desirable as it can reduce
  • a corner portion 74 that partially protrudes from the side surface of the water supply tank 53 is provided, and the laser water level sensor 71 is provided at the corner portion 74 . Further, in this case, by providing a planar shape 72 on the surface of the water supply tank 53 on the laser axis 73 of the laser water level sensor 71, the laser water level sensor 71 can stably monitor the water level from the outside of the water supply tank 53. It is desirable to
  • the material of the water supply tank 53 is desirably selected from those having physical properties that allow the wavelength of the laser light for the water level gauge to pass through, but do not allow water to pass through. Also, when multiple candidates are listed, it is desirable to consider the presence or absence of antibacterial function.
  • a sloped portion 601 that slopes upward in the vertical direction in a direction in which the diameter of the water supply tank 53 widens can be provided at a corner portion 74 of the side surface of the water supply tank 53 .
  • an inclined portion 602 having a lower angle of inclination than the inclined portion 601 and an inclined portion 603 on the surface on which the handle 75 is formed are also provided. can be done.
  • Such inclined portions 603 are provided on all surfaces other than the surface on which the corner portion 74 is formed, and the surfaces other than the bottom surface 301 have a cylindrical shape with a larger diameter than the bottom surface 301 side. It can be shaped like a bucket with a small diameter.
  • a handle 75 used by the operator of the automatic analyzer 100 when removing or attaching the water supply tank 53 is provided on the opposite side surface of the corner 74 .
  • At least one of the refilling ports 201 is desirably provided with a liquid leakage prevention structure.
  • each opening is provided with a stopper 701 and a spring 703 as a liquid leakage prevention structure.
  • a tube joint 704 having a pushrod 705 therein is fixed to each base portion where the refilling port 201, the supply port 202, and the return water inlet 203 of the water supply tank 53 are installed.
  • a slit is cut in the stopper 701 and the push slot 705 to allow pure water to pass.
  • FIG. 7 shows a state in which the water supply tank 53 is inserted into the tube joint 704.
  • the stopper 701 is pushed up by the pushrod 705 fixed to the tube joint 704, a gap is created between the stopper 701 and the bottom surface 702 of the water supply tank, enabling supply and discharge of pure water.
  • FIG. 8 shows a state in which the water supply tank is removed from the tube joint 704.
  • the stopper 701 separated from the push rod 705 is moved downward by the force of the spring 703, filling the gap between the stopper 701 and the bottom surface 702 of the water tank, making it impossible to discharge pure water.
  • the automatic analyzer 100 of the present embodiment described above includes a water supply tank 53 for temporarily storing liquid supplied from the outside of the apparatus and consumed by each mechanism of the automatic analyzer 100, and A supply flow path 64 connected to each mechanism, a water supply pump 54 for feeding the liquid in the water supply tank 53, and a circulation flow path 65 for returning the liquid discharged from the water supply pump 54 to the water supply tank 53,
  • the water supply tank 53 has a bottom surface 301 with an upward slope in which a swirling flow is formed in the water supply tank 53 by the liquid from the circulation flow path 65 .
  • Liquid is supplied to the water supply tank 53 from the outside of the device through a return water inlet 203 that serves as a connection between the water supply tank 53 and the circulation flow path 65, a supply port 202 that serves as a connection between the water supply tank 53 and the supply flow path 64.
  • the bottom surface 301 has refilling ports 201 for water replenishment, and each opening vertically from the bottom surface 301. Therefore, even if the pure water contains air bubbles, light air bubbles do not move vertically downward. is not so frequent, and it is possible to substantially prevent air bubbles from entering the side supplied to the analysis unit 101 side. For this reason, it is possible to prevent the water supply pump 54 from running idle and causing a failure, and the drop in water supply pressure from causing a drop in analytical performance. Also, the detachability of the water supply tank 53 can be improved.
  • the structure is improved in detachability, and from the bottom surface 301
  • the structure can be such that a spiral flow upward in the vertical direction can be easily formed.
  • a return water inlet 203 that serves as a connection between the water supply tank 53 and the circulation flow path 65
  • a supply port 202 that serves as a connection between the water supply tank 53 and the supply flow path 64
  • liquid is supplied to the water supply tank 53 from outside the apparatus.
  • the supply port 202 which is the connection portion between the water supply tank 53 and the supply channel 64, at a position lower in the vertical direction than the return water inlet 203, which is the connection portion between the water supply tank 53 and the circulation channel 65. It is possible to adopt an arrangement structure that can further suppress air bubbles from going to the water supply pump 54 side or the analysis unit 101 side.
  • the supply port 202 which is the connection portion between the water supply tank 53 and the supply channel 64, at a position lower in the vertical direction than the water supply port 201 for supplying liquid to the water supply tank 53 from the outside of the device, air bubbles It is possible to adopt an arrangement structure that can further suppress the flow of water toward the water supply pump 54 side or the analysis unit 101 side.
  • the water supply tank 53 has a cylindrical shape at least on the bottom surface 301 side, it is possible to minimize occurrence of places where water stays.
  • the water supply tank 53 has a cylindrical shape with a diameter larger than that of the bottom surface 301 side, the water supply tank 53 can continue the spiral flow upward in the vertical direction, thereby preventing the occurrence of places where water stays. can be reduced as much as possible.
  • the water supply tank 53 has a corner portion 74 from which a part of the side surface protrudes, so that the installation direction of the water supply tank 53 is easy to understand, and the tank shape can be made more workable for the user.
  • the inclined portion 601 is formed in the corner portion 74, the flow of pure water can also be created in the corner portion 74 due to the provision of the planar shape 72, thereby suppressing the accumulation of dirt such as germs. be able to.
  • the water supply port 201 is provided on the bottom surface of the water supply tank is illustrated, it can also be applied to the side surface of the water supply tank.
  • the surface of the recess 301a in which the supply port 202 is provided is in a flat state is illustrated, the surface condition does not matter as long as it is installed at a position lower than the outlet 201a on the side of the water replenishing port 201.
  • a mortar-like shape in which the diameter becomes smaller toward the center of the water supply port can also be applied.
  • the water supply port, the supply port, and the return water inlet can be provided on the side surface of the water supply tank 53 in addition to the bottom surface 301 of the water supply tank 53 .
  • the side surface may be opened perpendicularly to the side surface, but it is desirable that the return water inlet is tangential to the side surface of the water supply tank 53 . It is desirable that other replenishment ports and supply light are also tangential.
  • Water supply unit 201 Water supply port (water supply port) 201a... Outlet 202... Supply port (discharge port) 203... Return water inflow port (circulation port) 205... Cover 301... Ascending bottom surface 301a... Recessed portion 552... Float type water level sensor 553... Water supply tank 561... Refilling water port 561a... Outlet 562... Supply port 563... Water inlet 563a... Outlet 564... Cap 601, 602, 603... Inclined Part 701 Stopper 702 Water tank bottom surface 703 Spring 704 Tube joint 705 Push rod

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
PCT/JP2022/022295 2021-08-23 2022-06-01 自動分析装置、および自動分析装置用給水タンク Ceased WO2023026624A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US18/684,030 US20240425350A1 (en) 2021-08-23 2022-06-01 Automatic analyzer and water supply tank for automatic analyzer
CN202280050702.3A CN117716242A (zh) 2021-08-23 2022-06-01 自动分析装置以及自动分析装置用供水罐
JP2023543698A JP7696435B2 (ja) 2021-08-23 2022-06-01 自動分析装置、および自動分析装置用給水タンク
EP22859556.7A EP4393609A4 (en) 2021-08-23 2022-06-01 AUTOMATED ANALYSIS DEVICE AND SUPPLY TANK FOR AUTOMATED ANALYSIS DEVICE

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