WO2023013222A1 - 電解質分析装置および分析方法 - Google Patents
電解質分析装置および分析方法 Download PDFInfo
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- WO2023013222A1 WO2023013222A1 PCT/JP2022/022023 JP2022022023W WO2023013222A1 WO 2023013222 A1 WO2023013222 A1 WO 2023013222A1 JP 2022022023 W JP2022022023 W JP 2022022023W WO 2023013222 A1 WO2023013222 A1 WO 2023013222A1
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- ion
- concentration
- water quality
- diluent
- electrolyte analyzer
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- 239000003792 electrolyte Substances 0.000 title claims abstract description 57
- 238000004458 analytical method Methods 0.000 title claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 127
- 150000002500 ions Chemical class 0.000 claims abstract description 113
- 238000005259 measurement Methods 0.000 claims abstract description 58
- 239000003085 diluting agent Substances 0.000 claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 238000012545 processing Methods 0.000 claims abstract description 26
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 25
- 238000007865 diluting Methods 0.000 claims abstract description 10
- 239000012086 standard solution Substances 0.000 claims description 48
- 239000000243 solution Substances 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 32
- 230000008569 process Effects 0.000 claims description 28
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 18
- 239000003599 detergent Substances 0.000 claims description 16
- 229910001415 sodium ion Inorganic materials 0.000 claims description 16
- 230000002159 abnormal effect Effects 0.000 claims description 14
- 238000010790 dilution Methods 0.000 claims description 14
- 239000012895 dilution Substances 0.000 claims description 14
- 238000004140 cleaning Methods 0.000 claims description 9
- 238000012937 correction Methods 0.000 claims description 7
- 229910001414 potassium ion Inorganic materials 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 3
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims 4
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 claims 2
- 230000006866 deterioration Effects 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 30
- 230000002452 interceptive effect Effects 0.000 description 17
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 12
- 239000012488 sample solution Substances 0.000 description 6
- 239000008186 active pharmaceutical agent Substances 0.000 description 5
- 229940088679 drug related substance Drugs 0.000 description 5
- 239000002699 waste material Substances 0.000 description 5
- 238000004065 wastewater treatment Methods 0.000 description 5
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 4
- 239000012470 diluted sample Substances 0.000 description 4
- 229910001416 lithium ion Inorganic materials 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 229910001961 silver nitrate Inorganic materials 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 2
- 229910021607 Silver chloride Inorganic materials 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000008151 electrolyte solution Substances 0.000 description 2
- 229940021013 electrolyte solution Drugs 0.000 description 2
- 238000012417 linear regression Methods 0.000 description 2
- 229910001425 magnesium ion Inorganic materials 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
Definitions
- the present invention relates to an electrolyte analyzer and an analysis method.
- An electrolyte analyzer is a device that measures the concentration of specific electrolytes contained in electrolyte solutions (hereinafter sometimes referred to as specimens) such as blood and urine of the human body. Electrode) is used to measure the concentration using an ion-selective electrode method.
- an electrolyte analyzer for example, a flow-type electrolyte analyzer is known. In a flow-type electrolyte analyzer, serum as an electrolyte solution or a sample solution diluted with a sample diluent is supplied to an ion-selective electrode, and the liquid junction potential between the ion-selective electrode and a reference electrode solution is measured. .
- a standard solution with a known electrolyte concentration is supplied to the ion-selective electrode, and the inter-liquid potential with the reference electrode solution is measured in the same manner as the serum (or sample solution). Then, the electrolyte concentration of the serum (or sample solution) can be calculated from the two liquid junction potentials of the standard solution and serum (or sample solution).
- Patent Document 1 discloses that a chloride ion selective electrode and a reference electrode are immersed in a liquid to be measured, and the chloride ion concentration in the liquid to be measured is measured by the potential difference between the two electrodes. In doing so, a method for measuring chloride ion concentration is disclosed in which a silver/silver chloride electrode is used as the chloride ion selective electrode, and silver chloride is dissolved in a solution in contact with the electrode at a saturated concentration.
- a drug substance is supplied from a drug substance supply unit that supplies a drug substance corresponding to a reagent contained in a bottle, a pure water supply unit that supplies pure water to the bottle, and a drug substance supply unit.
- a drug substance supply unit that supplies a drug substance corresponding to a reagent contained in a bottle
- a pure water supply unit that supplies pure water to the bottle
- a drug substance supply unit Disclosed is an electrolyte concentration measuring device provided with a stirring mechanism section for stirring and mixing the pure water with the drug substance inside the bottle to which the pure water is supplied from the pure water supply section.
- a silver nitrate solution (AgNO3) is used as a diluent.
- AgNO3 silver nitrate solution
- wastewater treatment is essential in consideration of the environmental load, and this wastewater treatment causes an increase in treatment cost and treatment time.
- the amount of diluent used and the amount of wastewater used is large, so the running costs and other burdens are enormous.
- the diluted solution is produced by mixing the undiluted solution and pure water.
- wastewater treatment is essential.
- pure water is used to dilute the stock solution, since pure water is not standardized in the field of clinical testing, unspecified ions contained in the pure water may interfere with the measurement results of the electrolyte analyzer. An error may occur.
- the present invention has been made in view of the above, and it is an object of the present invention to provide an electrolyte analyzer and an analysis method that can suppress the burden associated with measurement while suppressing deterioration in the accuracy of measurement results.
- the present application includes a plurality of means for solving the above-mentioned problems, and to give an example, an ion-selective electrode used for measuring specific ions, an electrolyte analysis section including a reference electrode, and a reagent or specimen diluted and a control device for measuring the ion concentration in the liquid, wherein the control device dilutes a reagent of known concentration with the diluent A plurality of different concentrations of the diluent reagent having a known specific ion concentration are measured, and the water quality determination process of the diluent is performed based on the slope obtained from the measurement results.
- FIG. 1 A first embodiment of the present invention will be described in detail with reference to FIGS. 1 to 3.
- FIG. 1 A first embodiment of the present invention will be described in detail with reference to FIGS. 1 to 3.
- FIG. 1 A first embodiment of the present invention will be described in detail with reference to FIGS. 1 to 3.
- FIG. 1 A first embodiment of the present invention will be described in detail with reference to FIGS. 1 to 3.
- FIG. 1 A first embodiment of the present invention will be described in detail with reference to FIGS. 1 to 3.
- FIG. 1 is a diagram schematically showing the overall configuration of an electrolyte analyzer according to an embodiment of the present invention.
- an electrolyte analyzer a flow-type electrolyte analyzer (hereinafter simply referred to as an electrolyte analyzer) using an ion selective electrode (ISE) will be described. .
- ISE ion selective electrode
- an electrolyte analyzer 100 includes a specimen pipetting device 101, an ion-selective electrode group 102, a reference electrode 103, an internal standard solution bottle 104, a reference electrode solution bottle 105, a dilution tank 106, a water supply tank 107, and a syringe 108a. 108d, valves 109a to 109k, a waste liquid tank 110, and a control device 111.
- the specimen dispensing device 101 includes a sample probe 101a and a sample container 101b.
- a sample probe 101 a performs a dispensing process of aspirating a sample (such as a patient's specimen) held in a sample container 101 b and discharging it into the dilution tank 106 .
- a sample such as a patient's specimen
- the term "specimen” is a general term for analysis targets collected from a patient's living body, such as blood and urine.
- the specimen may be one obtained by pre-treating these analytes.
- the water supply tank 107 stores high-purity water (hereinafter referred to as system water) that is generally used in the electrolyte analyzer.
- System water is supplied to the water supply tank 107 via a valve 109a from a pure water production device (not shown) or the like.
- the system water stored in the water supply tank 107 is discharged to the dilution tank 106 through the system water nozzle 107a by the operation of the syringe (system water syringe) 108a and the valves 109b and 109c.
- the internal standard solution bottle 104 contains a standard solution with a predetermined known ion concentration for the ion species to be measured by the electrolyte analyzer 100 .
- the internal standard solution contained in the internal standard solution bottle 104 is generated to contain, for example, sodium ions (Na+), potassium ions (K+), chloride ions (Cl-), and the like.
- the internal standard solution stored in the internal standard solution bottle 104 is discharged to the dilution tank 106 through the internal standard solution nozzle 104a by the operation of the syringe (internal standard solution syringe) 108b and the valves 109d and 109e.
- a temperature controller 116 is provided in the channels of the system water nozzle 107a and the internal standard liquid nozzle 104a, and the temperature of the system water and the internal standard liquid passing through the channels is within a predetermined temperature range. adjusted to be
- the reference electrode liquid bottle 105 contains a reference electrode liquid having a predetermined known ion concentration.
- the reference electrode liquid stored in the reference electrode liquid bottle 105 is, for example, an aqueous solution of potassium chloride (KCl) containing potassium ions (K+) and chloride ions (Cl-).
- the reference electrode liquid stored in the reference electrode liquid bottle 105 is sent to the reference electrode 103 by the operation of the syringe (reference electrode liquid syringe) 108c and the valves 109f and 109g.
- the sample dispensed into the dilution tank 106 is diluted with system water discharged from the water supply tank 107 into the dilution tank 106 through the system water nozzle 107a by the operation of the syringe (system water syringe) 108a and the valves 109b and 109c. , is stirred.
- system water system water syringe
- the sample may be diluted using other diluents.
- the sample diluted with system water in the dilution tank 106 is sent to the ion-selective electrode group 102 through the sipper nozzle 102a by the operation of the syringe (sipper syringe) 108d and the valves 109h and 109i.
- the pinch valve 112 provided in the channel between the ion-selective electrode group 102 and the reference electrode 103 is temporarily opened.
- the internal standard solution discharged to the dilution tank 106 is also sent to the ion-selective electrode group 102 through the sipper nozzle 102a by the operation of the syringe (sipper syringe) 108d and the valves 109h and 109i. be.
- a plurality of ion-selective electrodes constituting the ion-selective electrode group 102 have specific ions (for example, sodium ions (Na+), potassium ions (K+), chloride ions (Cl-), etc.) in the sample solution.
- An ion-sensitive film is attached that has the property that the electromotive force changes according to the temperature. As a result, the ion-selective electrode group 102 outputs an electromotive force corresponding to each ion concentration in the sample solution.
- the pinch valve 112 When the pinch valve 112 is opened in a state in which the reference electrode solution is respectively sent to the reference electrode 103, the sample diluted to the ion-selective electrode group 102 is compared with the diluted sample sent to the channel.
- the electrode liquid is brought into contact with the ion-selective electrode group 102 and the reference electrode 103 to electrically conduct in the channel.
- the potential difference between each ion selective electrode of the ion selective electrode group 102 and the reference electrode 103 is measured by the voltmeter 113, and the measurement result (electrical signal) is sent to the controller 111 via the amplifier 114. Also, before or after the measurement of the diluted sample, the internal standard solution is measured in the same manner as the measurement of the diluted sample.
- control device 111 controls the overall operation of the electrolyte analyzer 100, and includes an arithmetic device such as a CPU (Central Processing Unit), a RAM (Random Access Memory) and an HHD (Hard Disk Drive). ) and an input/output device such as an I/O port.
- the storage device and the input/output device are configured to be able to exchange data with the processor via an internal bus or the like.
- the input/output device is connected to each mechanism of the electrolyte analyzer 100, and the control device 111 controls the operation of each mechanism via the input/output device.
- the controller 111 calculates the concentration of the specific electrolyte contained in the sample based on the potential difference between each ion selective electrode of the ion selective electrode group 102 and the reference electrode 103 . Further, by performing calibration based on the measurement results of the internal standard solution, the electrolyte concentration of the sample can be measured more accurately. A specific calibration method can be appropriately designed by those skilled in the art based on known techniques.
- the control device 111 stores the ion concentration calculated for each ion in a storage unit (not shown) and outputs it to an output device (for example, a display device).
- the sample and internal standard solution remaining in the dilution tank 106 are sucked by the waste liquid nozzle 115a through the operation of the vacuum bottle 115 and the valves 109j and 109k and sent to the waste liquid tank 110.
- the ion concentration of the system water in the water supply tank 107 is measured by the water quality measurement unit 200 (the ion selective electrode group 102, the reference electrode 103, and the voltmeter 113). Then, the control device 111 performs water quality determination processing to determine whether the water quality of the system water is normal or abnormal based on the measurement results.
- Figure 2 shows the potential difference between the ion-selective electrode and the reference electrode and the measurement target when measuring system water (hereinafter referred to as ionic solution) in which the ions to be measured by the ion-selective electrode are dissolved with an electrolyte analyzer. and the concentration of ions.
- ionic solution system water
- the ions to be measured are at a high concentration.
- the concentration logarithm (mmol/l) and the potential difference (mV) exhibit a proportional relationship regardless of whether the concentration is low or low.
- the relationship between the concentration logarithm value (mmol/l) and the potential difference (mV) is proportional when the concentration of the ions to be measured is low.
- a plurality of types of ionic solutions with known concentrations of the ions to be measured are generated for each of the high concentration region and the low concentration region, and the ion selective electrode group 102 and the reference electrode 103 , and obtain the slope of the relationship between the degree logarithm value (mmol/l) and the potential difference (mV) to estimate the concentration of interfering ions contained in the system water.
- the influence on the measurement accuracy of the electrolyte analyzer 100 can be reduced. Since it is possible to obtain the slope at the boundary between allowable and unacceptable interfering ion concentrations, this slope is used as a threshold to determine whether the system water quality is good (normal) or abnormal. Water quality judgment processing can be performed.
- chloride ions (Cl-) are measured using a diluted internal standard solution prepared by diluting an internal standard solution with system water as an ion solution
- Water quality determination processing is performed based on the results of measuring a plurality of types (for example, two types) of diluted internal standard solutions with different known concentrations in the high-concentration region and the low-concentration region.
- the electrolyte analyzer 100 in FIG. 1 can perform water quality judgment processing even with sodium ions (Na+) and potassium ions (K+). Also, if you have an ion-selective electrode that measures magnesium ions (Mg++) or an ion-selective electrode that measures lithium ions (Li+), water quality judgment processing is also performed with magnesium ions (Mg++) and lithium ions (Li+). It is possible.
- a diluted internal standard solution is used as an ionic solution
- a reference electrode solution or a calibrator used for calibration instead of the internal standard solution.
- Reagents with different known concentrations may be used, such as using an internal standard solution and a calibrator for each of the low concentration range and the high concentration range.
- the internal standard solution in the internal standard solution bottle 104 is discharged into the dilution tank 106 through the internal standard solution nozzle 104a, and the system water in the water supply tank 107 is discharged through the system water nozzle 107a into the dilution tank. Dispense to 106 .
- a diluted internal standard solution is generated by diluting an internal standard solution with a known concentration with system water at a predetermined ratio.
- the concentrations of the diluted internal standard solutions are, for example, two kinds of chloride ion (Cl-) concentrations of 80 (mmol/l) and 120 (mmol/l) in the high concentration region.
- the potential difference between the ion-selective electrode group 102 and the reference electrode 103 is measured with a voltmeter 113 for each of the diluted internal standard solutions having two different concentrations. Plot the measurement results. Then, a linear regression line is drawn between the two measurement results, and its slope is obtained. Let this slope be the slope at high density (SL1).
- the concentration of the diluted internal standard solution in the low concentration range is, for example, two kinds of chloride ion (Cl-) concentrations of 8 (mmol/l) and 12 (mmol/1).
- the potential difference between the ion-selective electrode group 102 and the reference electrode 103 is measured by the voltmeter 113 for the diluted internal standard solutions of these two concentrations, and the horizontal axis is the electrolyte concentration (logarithm).
- a linear regression line is drawn between the two measurement results, and its slope is obtained. Let this slope be the slope at low density (SL2).
- the measurement lower limit of each ion selective electrode of the ion selective electrode group 102 is sufficiently lower than 0.2 (mmol / l)
- the ratio of slope SL2 (SL2/SL1 x 100) based on slope SL1 is 100 (%). lower.
- the threshold value of the concentration of interfering ions set in consideration of the influence of interfering ions on measurement accuracy is 1.0 (mmol/l)
- the ratio of slope SL2 to slope SL1 (SL2/SL1 ⁇ 100) is 92. (%) or less, it can be determined that the influence on the measurement accuracy is unacceptable, that is, the water quality of the system water is abnormal.
- the concentration range of the high-concentration region is about 10 times or more that of the low-concentration region. The greater the concentration difference between the high-concentration region and the low-concentration region, the more pronounced the difference in slope, and the more accurately water quality abnormalities can be determined.
- the appropriate concentration range varies depending on the type of ion, and when water quality determination processing is performed with chloride ions (Cl-), the high concentration range is 80-120 (mmol/l), and the low concentration range is 8-12 (mmol/l). , 3-7 (mmol/l) when using potassium ions (K+), low concentration range 0.3-0.7 (mmol/l), high concentration range 120-160 when using sodium ions (Na+) (mmol/l), and a low concentration range of 12-16 (mmol/l) is suitable.
- the accuracy of the water quality determination process can be improved by performing the water quality determination process within the concentration range described above, the water quality determination process can be performed even outside the above concentration range.
- Equation 1 EMFH is the measured electromotive force of the high-concentration diluted internal standard solution
- EMFL is the measured electromotive force of the low-concentration diluted internal standard solution
- CH is the concentration specified value of the high-concentration diluted internal standard solution
- CL is the low Concentration specified value of diluted internal standard solution.
- concentration specified value of the high-concentration diluted internal standard solution and the concentration specified value of the low-concentration diluted internal standard solution are high concentration or low concentration concentration specified values in each concentration range.
- the concentration of the internal standard solution is determined by the following (Equation 2) and (Equation 3).
- CIS CL ⁇ 10a (Formula 2)
- a (EMFIS ⁇ EMFL)/SL (Formula 3)
- CIS is the concentration of the internal standard solution
- EMFIS is the electromotive force of the internal standard solution
- CS is the sample concentration
- E is the potential difference (mV) generated between the ion-selective electrode and the reference electrode
- E0 is the reference potential (mV)
- R is the gas constant (8.3144 J mol-1 K-1 )
- T is the absolute temperature (273.15+° C.)
- n is the ionic valence
- F is the Faraday constant (96.485 C ⁇ mol).
- FIG. 3 is a flowchart showing water quality determination processing.
- control device 111 when the control device 111 is instructed to start analysis, it first performs a reset operation (step S100).
- diluted internal standard solutions of multiple concentrations are generated and measured by the water quality measurement unit 200 (ion selective electrode group 102, reference electrode 103, voltmeter 113), and the electromotive force (potential difference) of each is measured (step S110).
- the slopes SL1 and SL2 are calculated from the measurement results of the diluted internal standard solution in the high concentration range and the diluted internal standard solution in the low concentration range (step S120), and whether or not the slope SL2 is within the reference range is determined. Determine (step S130).
- whether or not the slope SL2 is within the reference range is, for example, whether or not the ratio of the slope SL2 to the slope SL1 (SL2/SL1 ⁇ 100) is 92(%) or more. .
- step S130 If the determination result in step S130 is YES, it is determined that the water quality of the system water is normal (good), the sample concentration measurement operation is performed (step S140), and the measurement result is output (step S150). ) and terminate the process. At this time, since the water quality of the system water is guaranteed, the measurement result can be obtained with high accuracy.
- step S130 determines whether the water quality of the system water is abnormal. If the determination result in step S130 is NO, it is determined that the water quality of the system water is abnormal, a water quality abnormality alarm is issued (step S131), and the operation of the device is stopped (step S132). ) and terminate the process. At this time, it is detected that the water quality of the system water is abnormal, and the sample is not measured. can prompt improvement and restoration of the abnormal state promptly.
- an electrolyte analysis section including an ion-selective electrode used for measuring specific ions and a reference electrode, and a diluent supply for supplying a diluent for diluting a reagent or a specimen are provided. and a control device, wherein the control device dilutes a reagent of known concentration with a diluent to generate a plurality of different concentrations of specific ions. measures each of the known diluted reagents, and performs the water quality determination process of the diluted solution based on the slope obtained from the measurement results. can be suppressed.
- This embodiment describes an example of calculating a correction coefficient instead of issuing an alarm when the concentration of interfering ions is not within the reference range.
- Other configurations are the same as those of the first embodiment, and only points different from the first embodiment will be described.
- FIG. 4 is a flowchart showing water quality determination processing according to the present embodiment. Since the processing when the slope is within the reference range (that is, the processing of steps S100 to S150) is the same as in the first embodiment, only the processing of steps S231 to S232 will be described in this embodiment.
- step S130 determines that the water quality of the system water is abnormal.
- the correction coefficient is calculated (step S231), and the specimen concentration measurement operation is performed (step 232).
- the sample measurement result is corrected (step S233), and the process ends.
- the correction factor corrects the variation in the measurement result of the specimen due to the influence of the interfering ions.
- the correction coefficient according to the concentration of the interfering ions to the measurement result of the sample, it is possible to obtain a more accurate measurement result.
- the measurement result of the sample is corrected according to the interfering ion concentration, so that the sample measurement operation can be performed with high accuracy without stopping the measurement operation. can be done.
- the water supply tank 107 is periodically washed by the user with detergent.
- Detergents are, for example, sodium hypochlorite containing chloride ions (Cl-) and sodium ions (Na+), chloride ions (Cl-) chlorine dioxide, and if rinsing after washing is not enough, the ions in the detergent Interfering ions may affect the measurement results of the sample. Therefore, in the present embodiment, an example in which water quality determination processing is performed after cleaning the water supply tank 107 will be described.
- FIG. 5 is a flow chart showing cleaning processing according to the present embodiment.
- step S300 when washing is instructed, detergent is first put into the water supply tank 107 to wash the water supply tank (step S300). Rinsing is performed (step S310). Subsequently, in order to check whether detergent remains in the water supply tank after the rinsing operation, the electromotive forces of the ionic solutions of multiple concentrations are measured (step S320), and a slope is generated from the measurement results (step S330). ). Subsequently, it is determined whether or not the slope SL2 is within the reference range (step S340). Since the processes of steps S320 to S330 are the same as those of steps S110 to S130 of the first embodiment, detailed description thereof will be omitted.
- step S340 If the determination result in step S340 is YES, it is determined that no detergent remains (rinsing is sufficient), and the process ends. Further, if the determination result in step S340 is NO, it is determined that the rinsing is insufficient and the detergent remains, the process returns to step 310, and the processing of steps S310 to S330 is repeated until the determination result becomes YES. Repeat the rinsing action.
- the ionic solution contains at least the ions contained in the detergent and to be measured by the ion-selective electrode. There is a need.
- steps S320 to S330 are performed by the user instructing the execution of the water quality determination process, and it is notified whether or not the detergent remains. If so, the user can be prompted for an additional rinse.
- SL1 and SL2 were obtained by measuring the ion solution in the high concentration range and the ion solution in the low concentration range, and the water quality determination process was performed. was not measured.
- a theoretical value may be obtained instead of SL1. Since the theoretical value and the measured value are different, the accuracy of water quality judgment is lower than when measuring the ion solution and obtaining SL1, but the slope when interfering ions are not included can be calculated with the theoretical value, and the water quality judgment It is possible to save the reagents used for the treatment. Further, in the above-described embodiment, the high-concentration ionic solution and the low-concentration ionic solution are measured in the high-concentration range and the low-concentration range, respectively.
- SL1 and SL2 may be obtained by using the same concentration ion solution as the high concentration ion solution in the low concentration region. As mentioned above, if there is a concentration range difference of about 10 times between the high concentration area and the low concentration area, it is possible to judge the water quality with high accuracy. Determination can be performed, and reagents used for water quality determination processing can be saved.
- Electrolyte analyzer 101... Specimen dispensing apparatus, 101a... Sample probe, 101b... Sample container, 102... Ion-selective electrode group, 102a... Sipper nozzle, 103... Reference electrode, 104... Internal standard liquid bottle , 104a... Internal standard solution nozzle, 105... Reference electrode solution bottle, 106... Dilution tank, 107... Water supply tank, 107a... System water nozzle, 108a... System water syringe, 108b... Internal standard solution syringe, 108c... Reference electrode solution syringe , 108d... Sipper syringe, 109a to 109k... Valve, 110... Waste liquid tank, 111... Control device, 112... Pinch valve, 113... Voltmeter, 114... Amplifier, 115... Vacuum bottle, 115a... Waste liquid nozzle, 116... Temperature adjustment Instrument, 200... Water quality measuring part
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Abstract
Description
本発明の第1の実施の形態を図1~図3を参照しつつ詳細に説明する。
SL=(EMFH-EMFL)/(LogCH-LogCL)…(式1)
CIS=CL×10a…(式2)
a=(EMFIS-EMFL)/SL…(式3)
E=E0+(2.303RT/zF)・logCS…(式4)
本発明の第2の実施形態を、図4を参照し説明する。
<第3の実施形態>
本発明の第3の実施形態を、図5を参照し説明する。
本発明は上記の実施の形態に限定されるものではなく、その要旨を逸脱しない範囲内の様々な変形例や組み合わせが含まれる。
なお、本発明は上記の実施の形態に限定されるものではなく、その要旨を逸脱しない範囲内の様々な変形例や組み合わせが含まれる。また、上記の実施の形態で説明した全ての構成を備えるものに限定されず、その構成の一部を削除したものも含まれる。また、上記の各構成、機能等は、それらの一部又は全部を、例えば集積回路で設計する等により実現してもよい。また、上記の各構成、機能等は、プロセッサがそれぞれの機能を実現するプログラムを解釈し、実行することによりソフトウェアで実現してもよい。
Claims (15)
- 特定のイオンの測定に用いるイオン選択性電極と、比較電極とを含む電解質分析部と、
試薬または検体を希釈するための希釈液を供給する希釈液供給部と、
制御装置と、
を有し、液体中のイオン濃度を測定する電解質分析装置において、
前記制御装置は、前記希釈液により既知濃度の試薬を希釈し生成した異なる複数濃度の、前記特定のイオンの濃度が既知の希釈試薬を、それぞれ測定し、
測定結果から得られる傾きに基づいて、前記希釈液の水質判定処理を行うことを特徴とする電解質分析装置。 - 請求項1記載の電解質分析装置において、
前記既知濃度の試薬は、内部標準液、キャリブレータまたは比較電極液であることを特徴とする電解質分析装置。 - 請求項1記載の電解質分析装置において、
前記制御装置は、異なる4濃度の前記希釈試薬を測定し、高濃度域の2濃度の測定結果から得られる傾きと、低濃度域の2濃度の測定結果から得られる傾きとに基づいて、前記希釈液の水質判定処理を行うことを特徴とする電解質分析装置。 - 請求項3記載の電解質分析装置において、
前記高濃度域の濃度は、前記低濃度域の濃度の10倍以上であることを特徴とする電解質分析装置。 - 請求項4記載の電解質分析装置において、
前記特定のイオンが
クロールイオン(Cl-)の場合、低濃度域の濃度範囲は8-12(mmol/l)、
カリウムイオン(K+)の場合、低濃度域の濃度範囲は0.3-0.7(mmol/l)、
ナトリウムイオン(Na+)の場合、低濃度域の濃度範囲は12-16(mmol/l)
であることを特徴とする電解質分析装置。 - 請求項1又は2記載の電解質分析装置において、
前記特定のイオンが
クロールイオン(Cl-)の場合8-12(mmol/l)、
カリウムイオン(K+)の場合0.3-0.7(mmol/l)、
ナトリウムイオン(Na+)の場合12-16(mmol/l)、
の範囲から選択されるイオンの濃度の希釈試薬を複数濃度で測定した結果から得られる傾きに基づいて、前記希釈液の水質判定処理を行うことを特徴とする電解質分析装置。 - 請求項1~6の何れか一項に記載の電解質分析装置において、
前記制御装置は、前記水質判定処理において、前記希釈液の水質が異常であると判定された場合に、前記希釈液のイオン濃度に応じて予め定めた補正係数を用いて、前記イオン選択性電極による前記検体の測定結果を補正することを特徴とする電解質分析装置。 - 請求項1~6の何れか一項に記載の電解質分析装置において、
前記水質判定処理において、前記希釈液の水質が異常であると判定された場合に、アラームを発することを特徴とする電解質分析装置。 - 請求項1~6の何れか一項に記載の電解質分析装置において、
前記希釈液を貯留する給水タンクを有し、
前記給水タンクの洗剤を用いた洗浄及びすすぎを含む洗浄処理後の前記水質判定処理において、前記希釈液の水質が異常であると判定された場合は、洗剤が残留していると判定することを特徴とする電解質分析装置。 - 請求項1~8の何れか一項に記載の電解質分析装置において、
前記希釈液はシステム水であることを特徴とする電解質分析装置。 - イオン選択性電極と、比較電極との電位差に基づき液体中の特定のイオンのイオン濃度を測定する分析方法において、
試薬または検体を希釈するための希釈液により既知濃度の試薬を希釈し生成した複数濃度の、前記特定のイオンの濃度が既知の希釈試薬をそれぞれ測定した結果から得られる傾きに基づいて、前記希釈液の水質判定処理を行うことを特徴とする分析方法。 - 請求項11記載の分析方法において、
異なる4濃度の前記希釈試薬を測定し得られた測定結果のうち、高濃度域の2濃度の測定結果から得られる傾きと、低濃度域の2濃度の測定結果から得られる傾きとに基づいて、前記希釈液の水質判定処理を行うことを特徴とする分析方法。 - 請求項11記載の分析方法において、
前記特定のイオンが
クロールイオン(Cl-)の場合8-12(mmol/l)、
カリウムイオン(K+)の場合0.3-0.7(mmol/l)、
ナトリウムイオン(Na+)の場合12-16(mmol/l)、
の範囲から選択されるイオンの濃度の希釈試薬を複数濃度で測定した結果から得られる傾きに基づいて、前記希釈液の水質判定処理を行うことを特徴とする分析方法。 - 請求項11~13の何れか一項に記載の分析方法において、
前記水質判定処理により、希釈壁の水質が異常と判断された場合に、前記希釈液のイオン濃度に応じて予め定めた補正係数を用いて、前記イオン選択性電極による前記検体の測定結果を補正することを特徴とする分析方法。 - 請求項11~13の何れか一項に記載の分析方法において、
希釈液を貯留する給水タンクの洗剤を用いた洗浄処理とすすぎ処理とを含む洗浄工程を有し、
前記洗浄工程後の前記水質判定処理において、前記希釈液の水質が異常であると判定された場合は、洗剤が残留していると判定することを特徴とする分析方法。
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