WO2022222591A1 - Souche de lactobacillus paracasei pour améliorer l'effet thérapeutique d'un inhibiteur de point de contrôle immunitaire et son utilisation - Google Patents
Souche de lactobacillus paracasei pour améliorer l'effet thérapeutique d'un inhibiteur de point de contrôle immunitaire et son utilisation Download PDFInfo
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- WO2022222591A1 WO2022222591A1 PCT/CN2022/077453 CN2022077453W WO2022222591A1 WO 2022222591 A1 WO2022222591 A1 WO 2022222591A1 CN 2022077453 W CN2022077453 W CN 2022077453W WO 2022222591 A1 WO2022222591 A1 WO 2022222591A1
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- paracasei
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- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 title claims abstract description 16
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 title claims abstract description 16
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/125—Casei
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
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- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Polymers & Plastics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne une souche de Lactobacillus paracasei pour améliorer l'effet thérapeutique d'un inhibiteur de point de contrôle immunitaire et son utilisation, la souche possédant le numéro de dépôt CCTCC NO : M 2020474. En outre, la souche peut recruter et augmenter l'infiltration et l'activation des lymphocytes T CD8 tueurs dans un tissu de cellules tumorales, et promouvoir l'effet thérapeutique d'un anticorps PD-1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110434508.2 | 2021-04-22 | ||
| CN202110434508.2A CN112877268A (zh) | 2021-04-22 | 2021-04-22 | 一种增强免疫检查点抑制剂治疗效应的干酪乳杆菌株及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2022222591A1 true WO2022222591A1 (fr) | 2022-10-27 |
Family
ID=76040091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2022/077453 WO2022222591A1 (fr) | 2021-04-22 | 2022-02-23 | Souche de lactobacillus paracasei pour améliorer l'effet thérapeutique d'un inhibiteur de point de contrôle immunitaire et son utilisation |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN112877268A (fr) |
| WO (1) | WO2022222591A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112877268A (zh) * | 2021-04-22 | 2021-06-01 | 上海耀旦生物科技有限公司 | 一种增强免疫检查点抑制剂治疗效应的干酪乳杆菌株及其应用 |
| CN114164148B (zh) * | 2021-11-29 | 2022-11-25 | 天津科技大学 | 一株马乳酒样乳杆菌、菌剂及其应用 |
| CN114657086A (zh) * | 2021-12-27 | 2022-06-24 | 苏州善佰生物技术有限公司 | 一种双歧杆菌的制备方法及其在肿瘤治疗中的应用 |
| CN114306616B (zh) * | 2022-01-12 | 2023-04-28 | 广州知易生物科技有限公司 | 脆弱拟杆菌和免疫检查点抑制剂的新应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017129769A1 (fr) * | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes permettant d'améliorer la puissance d'inhibiteurs de points de contrôle immunitaires |
| WO2018222969A1 (fr) * | 2017-06-02 | 2018-12-06 | Board Of Regents, The University Of Texas System | Espèce bactérienne spécifique et métabolite qui améliore l'efficacité thérapeutique d'un inhibiteur de point de contrôle immunitaire |
| CN109771445A (zh) * | 2019-03-20 | 2019-05-21 | 青岛东海药业有限公司 | 酪酸梭菌在制备诱导抗肿瘤免疫及免疫检查点抑制剂增敏制剂中的应用 |
| CN109966320A (zh) * | 2019-04-26 | 2019-07-05 | 青岛东海药业有限公司 | 凝结芽孢杆菌在制备诱导抗肿瘤免疫及免疫检查点抑制剂增敏制剂中的应用 |
| CN112334141A (zh) * | 2018-06-14 | 2021-02-05 | 株式会社明治 | 用于促进免疫检查点抑制疗法的组合物 |
| CN112877268A (zh) * | 2021-04-22 | 2021-06-01 | 上海耀旦生物科技有限公司 | 一种增强免疫检查点抑制剂治疗效应的干酪乳杆菌株及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020500151A (ja) * | 2016-09-27 | 2020-01-09 | ボード オブ リージェンツ， ザ ユニヴァーシティー オブ テキサス システム | マイクロバイオームをモジュレートすることにより、免疫チェックポイント遮断療法を増強するための方法 |
| CN110305821B (zh) * | 2019-08-28 | 2019-12-17 | 鲁东大学 | 副干酪乳杆菌配合car-t细胞治疗应用 |
| CN111560330B (zh) * | 2020-05-12 | 2022-04-26 | 天津科技大学 | 一种具有免疫调节、抗炎和抗宫颈癌作用的干酪乳杆菌及应用 |
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2021
- 2021-04-22 CN CN202110434508.2A patent/CN112877268A/zh active Pending
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2022
- 2022-02-23 CN CN202210169659.4A patent/CN114540229A/zh active Pending
- 2022-02-23 WO PCT/CN2022/077453 patent/WO2022222591A1/fr active Application Filing
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| WO2018222969A1 (fr) * | 2017-06-02 | 2018-12-06 | Board Of Regents, The University Of Texas System | Espèce bactérienne spécifique et métabolite qui améliore l'efficacité thérapeutique d'un inhibiteur de point de contrôle immunitaire |
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| CN109771445A (zh) * | 2019-03-20 | 2019-05-21 | 青岛东海药业有限公司 | 酪酸梭菌在制备诱导抗肿瘤免疫及免疫检查点抑制剂增敏制剂中的应用 |
| CN109966320A (zh) * | 2019-04-26 | 2019-07-05 | 青岛东海药业有限公司 | 凝结芽孢杆菌在制备诱导抗肿瘤免疫及免疫检查点抑制剂增敏制剂中的应用 |
| CN112877268A (zh) * | 2021-04-22 | 2021-06-01 | 上海耀旦生物科技有限公司 | 一种增强免疫检查点抑制剂治疗效应的干酪乳杆菌株及其应用 |
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| JIN YUEPING, DONG HUI, XIA LILIANG, YANG YI, ZHU YONGQIANG, SHEN YAN, ZHENG HUAJUN, YAO CHENGCHENG, WANG YING, LU SHUN: "The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti–Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC", JOURNAL OF THORACIC ONCOLOGY, ELSEVIER INC., US, vol. 14, no. 8, 1 August 2019 (2019-08-01), US , pages 1378 - 1389, XP055809261, ISSN: 1556-0864, DOI: 10.1016/j.jtho.2019.04.007 * |
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| Publication number | Publication date |
|---|---|
| CN112877268A (zh) | 2021-06-01 |
| CN114540229A (zh) | 2022-05-27 |
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