Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
  • A61K6/851—Portland cements
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
  • A61K6/61—Cationic, anionic or redox initiators
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
  • A61K6/853—Silicates
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
  • A61K6/858—Calcium sulfates, e.g, gypsum
• • C—CHEMISTRY; METALLURGY
  • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
  • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
  • C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
  • C04B28/02—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
  • C04B28/04—Portland cements
• • C—CHEMISTRY; METALLURGY
  • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
  • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
  • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
  • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
  • C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications

Definitions

• the present invention relates to dental cement. Specifically, the present invention relates to a novel dental cement that can be suitably used for applications such as root canal filling of teeth and direct pulp capping.
• MTA Minal Trioxide Aggregate
• MTA is made by atomizing Portland cement, which is a mortar material for concrete for civil engineering and construction, into fine particles for dentistry, and adding an inorganic substance having X-ray impermeableness such as bismuth oxide, which is hydrated by kneading with water. It cures by the reaction.
• This cured product has excellent biocompatibility and ability to induce hard tissue, and leads to treatment with new hard tissue formation in the pulp and root periodontal tissue, so that it can be directly pulp capped, demyelinated, apexifation, or vice versa. It has clinical applications such as root canal filling and closure of perforations.
• MTA is generally composed of a powder component and a liquid component, and is hardened by mixing and kneading both components to form a hardened cement product.
• the clinical procedure of MTA is that, for example, in the case of exposed spinal teeth, after applying to the exposed spinal cord, a superstructure such as a temporary sealant or a prosthesis is formed on the exposed spinal cord. Since it is cured by the hydration reaction, the reaction rate is slow and it takes several days to completely cure. Therefore, there is a problem that the strength is weak and the solubility tends to be high immediately after application.
• the powder component and the liquid component of the MTA it is necessary to knead the powder component and the liquid component of the MTA to prepare it, which makes it difficult to knead and make a uniform paste. If the powder-liquid ratio (mixing ratio of the powder component to the liquid component) is lowered in order to improve the kneadability, the paste of the kneaded product tends to drip, which makes filling and other operations difficult, and the curing reaction is slow. There is also a problem that the strength of the cured product is further reduced.
• Patent Document 1 a means for solving problems such as reaction rate, strength immediately after application, and solubility by using MTA as a polymer wet structure has been proposed. Further, a composition containing an MTA, a polymerizable monomer, a filler, and a polymerization initiator and imparting operability and mechanical strength, as well as adhesiveness and sealing property is disclosed (Patent Document 2). Further, a composition having improved operability and physical properties by mixing a hydrogel forming agent with an MTA is disclosed (Patent Document 3).
• compositions disclosed in Patent Documents 1 to 3 contain a polymer in the cured product obtained by curing, the excellent biocompatibility and hard tissue inducing ability inherent in the MTA are exhibited. It could have an effect.
• the present invention is for dental use, in which operability such as kneading property and filling is not easily affected by the powder-liquid ratio, operability is excellent, and a cured product having excellent compressive strength can be obtained.
• the purpose is to provide cement.
• the present inventors simply mixed and kneaded Portland cement powder and water by mixing and kneading Portland cement powder, a cationic surfactant, and water. It was found that it is easier to knead than in the case of the above, and it is possible to obtain a kneaded product having excellent properties. Further, even if the amount of the liquid component mixed at the time of kneading is smaller than that of the powder component containing Portland cement powder (high powder liquid ratio), it is less likely to cause any trouble during the operation of the paste of the kneaded product, and further, the properties are It was found that an excellent cured product could be obtained, and further studies were carried out to complete the present invention.
• the present invention includes the following inventions.
• a powder component and a liquid component are provided.
• the powder component contains Portland cement powder (A).
• the liquid component contains water (C) and contains Dental cement in which at least one of the powder component or the liquid component contains a cationic surfactant (B).
• the cationic surfactant (B) is at least one selected from the group consisting of cetylpyridinium chloride, 12-methacryloxide decylpyridinium bromide, hexadecyltrimethylammonium chloride, and octadecyltrimethylammonium chloride [1]. ]
• the dental cement according to any one of.
• a dental cement capable of obtaining a cured product having excellent operability and compressive strength, in which operability such as kneading property and filling is not easily affected by the powder-liquid ratio. Will be done. Further, according to the present invention, Ca ion sustained release property is excellent.
• the dental cement of the present invention comprises a powder component and a liquid component, wherein the powder component contains Portland cement powder (A), the liquid component contains water (C), and the powder component or the liquid. At least one of the components comprises a cationic surfactant (B).
• a cationic surfactant B
• (meth) acryloyloxy is a general term for methacryloyloxy and acryloyloxy.
• the upper limit value and the lower limit value of the numerical range content of each component, value calculated from each component, each physical property, etc.
• Portland cement powder is kneaded by adding water to start the hydration reaction and proceed with the curing reaction.
• Portland cement powder and water are not well-familiar with each other, so that it is difficult for water and powder to become one and have a lumpy feeling, and it is difficult to knead them into a paste.
• the surface active function of the cationic surfactant enhances the compatibility between the Portland cement powder and water, and the agglomeration of the Portland cement powder is crushed by kneading, so that a hydration reaction can occur in the entire Portland cement powder. .. That is, the hydration reaction is brought about up to each grain of Portland cement powder. Furthermore, by increasing the familiarity between the Portland cement powder and water, the feeling of kneading becomes smooth and the operability of mixing is improved.
• the cationic surfactant (B) is selected as the surfactant of the present invention is that the Portoland cement powder is basic and hydrated because it releases metal ions which are cationics in the process of hydration reaction. This is because the reaction environment is strongly basic. Even in such an environment, the cationic surfactant can bring about an effective surfactant action.
• anionic surfactants do not function as surfactants because they are adsorbed on Portland cement powder or neutralized by metal ions, and the adsorption itself on Portland cement powder hinders the hydration reaction. Become.
• the nonionic surfactant does not sufficiently function as a surfactant in a strongly basic hydration reaction environment, and rather inhibits as a foreign substance in the hydration reaction between Portland cement powder and water. Will be the existence that brings about.
• the dental cement of the present invention has a powder component and a liquid component. In such a packaged state, it is easier to knead the mixture as compared with the case where Portland cement powder and water are simply mixed and kneaded, and a kneaded product having excellent properties can be obtained. Further, even if the amount of the liquid component mixed at the time of kneading is small (high powder liquid ratio), it is unlikely to cause any trouble during the operation of the paste of the kneaded product, so that a cured product having better properties can be obtained.
• Portland cement powder (A) conventional Portland cement (general-purpose Portland cement) generally used for civil engineering and construction can be used without particular limitation, but can be appropriately refined and used for dental purposes. / Or, one containing an additive is preferable.
• Examples of the Portland cement used in the present invention include ordinary Portland cement, early-strength Portland cement, ultra-early-strength Portland cement, white Portland cement, sulfate-resistant Portland cement, and moderate heat Portland cement specified in JIS R 5210: 2019.
• Examples include powders such as low heat Portland cement.
• Portland cement powder (A) especially if it has the following composition, cures in a stable state when the kneaded product is cured under high water conditions such as root canal filling and pulp capping. It is more preferable from the viewpoint that the strength can be increased and an appropriate strength can be obtained.
• the Portland cement powder (A) may contain other components such as magnesium oxide and sodium carbonate.
• the Portland cement powder (A) used in the present invention is tricalcium silicate (Alite, 3CaO ⁇ SiO 2 ), dicalcium silicate (Belite, 2CaO ⁇ SiO 2 ), calcium aluminate (aluminate, 3CaO ⁇ ).
• Al 2 O 3 ) and calcium aluminoferrite (ferrite, 4CaO, Al 2 O 3 , Fe 2 O 3 ) are the main components of the cement.
• CaO calcium oxide
• SiO 2 silicon dioxide
• Al 2 O 3 aluminum oxide
• Fe 2 O 3 iron oxide
• the general composition of generally well-known Portland cement is such that the CaO content is preferably 4 to 85% by mass in terms of oxides of each element. It is preferably 40 to 85% by mass, more preferably 55 to 75% by mass, and particularly preferably 60 to 70% by mass.
• the content of SiO 2 is preferably 10 to 95% by mass, more preferably 10 to 50% by mass, still more preferably 15 to 40% by mass, and particularly preferably 18 to 32% by mass.
• the content of Al 2 O 3 is preferably 0 to 17% by mass, more preferably 0 to 15% by mass, still more preferably 1.5 to 8% by mass, and particularly preferably 2.5 to 6% by mass.
• the content of Fe 2 O 3 is preferably 0 to 4.7% by mass, more preferably 0 to 4.5% by mass, still more preferably 0.2 to 2% by mass, and particularly preferably 0.5 to 1% by mass. %.
• the content of MgO is preferably 0.02 to 5% by mass, more preferably 0.2 to 5% by mass, still more preferably 0.7 to 3% by mass, and particularly preferably 0.8 to 2% by mass. ..
• the residue of these components is a transition metal other than the above (for example, vanadium, copper), other alkali metal elements, and the like.
• an amorphous form such as fumed silica, nano-sized or spherical silicon dioxide may be contained as a Portland cement component.
• Portland cement powder (A) each of these components rarely exists alone as a powder or particles, but exists as a solid solution in which a plurality of components are mixed.
• metal oxide powder such as calcium oxide, silicon dioxide, aluminum oxide and iron oxide as a main component and calcium sulfate
• other powder components such as metal salt powder such as calcium carbonate, silica glass, and the like. It can contain an inorganic substance having a glass filler such as aluminum-containing glass.
• the average particle size of the Portland cement powder (A) is preferably 100 ⁇ m or less, more preferably 1 to 50 ⁇ m, and even more preferably 5 to 30 ⁇ m.
• the average particle size of the Portoland cement powder (A) means the particle size at a cumulative volume of 50% in the particle size distribution measured by the laser diffraction / scattering method, that is, D50 (median diameter).
• a laser diffraction type particle size distribution measuring device (“SALD-2300” manufactured by Shimadzu Corporation, etc.) can be used for measurement on a volume basis using ethanol as a dispersion medium.
• Examples of the form of Portland cement powder (A) include powder, granules and the like.
• Portland cement powder (A) for example, commercially available products such as “Proroute MTA” (manufactured by DENTSPLY-Sankin Co., Ltd.) and “White cement” (manufactured by Taiheiyo Cement Co., Ltd.) can also be used.
• the cationic surfactant (B) used in the present invention enhances the compressive strength of the cured product after the dental cement containing the Portland cement powder (A) is cured. Further, since the cationic surfactant (B) facilitates kneading as compared with the case where Portland cement powder and water are simply mixed and kneaded, a kneaded product having excellent properties can be obtained. Even if the ratio of the powdered agent at the time of kneading is increased, the operation of the paste of the kneaded product is less likely to be hindered, so that a cured product having excellent properties is further obtained.
• Examples of the cationic surfactant (B) used in the present invention include monoalkyltrimethylammonium salt, dialkyldimethylammonium salt, trialkylmonomethylammonium salt, tetraalkylammonium salt, monoalkyldimethylbenzylammonium salt, and polyoxyethylenealkylmethylammonium. Salts, compounds represented by the following general formula (I) and the like can be preferably used.
• R is a hydrogen atom or a (meth) acryloyloxy group
• n is an integer of 10 to 20
• X is a chlorine atom or a bromine atom
• Specific compounds of the cationic surfactant (B) include cetylpyridinium chloride (CPC), 12-methacryloxide decylpyridinium bromide (MDPB), hexadecyltrimethylammonium chloride (CTC), octadecyltrimethylammonium chloride (ODTC) and the like. Can be mentioned.
• the cationic surfactant (B) can be used alone or in combination of two or more.
• the cationic surfactant represented by the above general formula (I) can be preferably used from the viewpoint of the kneadability of the powder component and the liquid component and the strength of the cured product.
• an alkylpyridinium chloride salt, a methacryloyloxyalkylpyridinium chloride salt, a methacryloyloxyalkylpyridinium bromide salt and the like are particularly preferable, and more specifically, cetylpyridinium chloride, 12 -Metacryloxide decylpyridinium bromide is more preferred.
• the proportion of the cationic surfactant (B) in the dental cement is preferably 0.01 to 6% by mass, preferably 0.05 to 5.5% by mass. It is more preferably 0.1 to 5% by mass, and even more preferably 0.1 to 5% by mass.
• At least one of the powder component and the liquid component contains a cationic surfactant (B).
• the ratio of the cationic surfactant (B) in the liquid component is preferably 0.05 to 25% by mass. , 0.1 to 15% by mass, more preferably 0.2 to 10% by mass, and particularly preferably 0.2 to 6% by mass.
• the ratio of the cationic surfactant (B) in the liquid component is 0.05% by mass or more, the effect of improving operability and the strength of the cured product can be enhanced.
• it is 25% by mass or less the effect of increasing the strength of the cured product can be obtained.
• the dental cement according to the present invention may contain a cationic surfactant (B) even in the powder component.
• the ratio of the cationic surfactant (B) in the powder component is preferably 0.1 to 5% by mass, more preferably 0.1 to 4.5% by mass. When it is 0.1% by mass or more, the effect of improving operability and the strength of the cured product can be enhanced. On the other hand, when it is 5% by mass or less, the effect of increasing the strength of the cured product can be obtained.
• the water (C) used in the present invention is a component that causes a hydration reaction by miscibility with the powder component to promote curing, and also functions as a solvent for dissolving the cationic surfactant (B).
• the ratio of the powder component to the liquid component is not particularly limited, but from the viewpoint that the effect of the present invention is more excellent, the liquid component is 10 to 70 parts by mass with respect to 100 parts by mass of the powder component. It is preferably 15 to 70 parts by mass, more preferably 15 to 50 parts by mass.
• the dental cement of the present invention has excellent kneadability even when there are many powder components, and a cured product having excellent compressive strength can be obtained.
• the powder component of the dental cement according to the present invention may contain an X-ray contrast material in order to impart X-ray contrast.
• the X-ray contrast material contains known powders of bismuth oxide, barium sulfate, tantalum oxide, cerium oxide, tin oxide, zirconium oxide, zinc oxide, ytterbium oxide and ytterbium fluoride, and barium, tantalum, lanthanum and strontium.
• X-ray permeable glass powder and the like can be used, and these can be used alone or in combination.
• the content of the X-ray contrast medium may be any amount as long as it does not impair the effect of the present invention, and is preferably 0.1 to 50% by mass in the powder component, for example. If it is less than 0.1% by mass, the X-ray contrast property of the cured product obtained by kneading with the liquid component tends to be insufficient, and if it exceeds 50% by mass, the strength of the cured product may decrease.
• the dental cement of the present invention can be blended with other additives such as fillers, colorants and stabilizers as long as it does not affect the physical properties and operability.
• additives such as fillers, colorants and stabilizers as long as it does not affect the physical properties and operability.
• the additive one type may be used alone, or two or more types may be used in combination.
• the content of the additive is preferably less than 10% by mass, more preferably 0 to 5% by mass, and even more preferably 0 to 3% by mass in the dental cement.
• the compressive strength of the cured product of the dental cement of the present invention is preferably more than 40 MPa, more preferably 45 MPa or more, and even more preferably 50 MPa or more.
• the method for measuring the compressive strength of the cured product is as described in Examples described later.
• dental cement according to the present invention will be specifically described with reference to Examples, but the dental cement according to the present invention is not limited to the following Examples.
• CPC Cetylpyridinium chloride
• MDPB 12-methacryloyloxide decylpyridinium bromide
• CTC Hexadecyltrimethylammonium chloride
• ODTC Octadecyltrimethylammonium chloride
• Mdosurfactant other than cationic surfactant B)
• DBS Sodium dodecylbenzenesulfonate
• MDP 10- Methacryloyloxydecyldihydrogen phosphate
• Examples 1 to 21 and Comparative Examples 1 to 4 A cured product of dental cement was prepared by the formulations shown in Tables 1, 2 and 3, and the kneadability, operability and compressive strength were measured and evaluated. The results are shown in Tables 1, 2 and 3.
• Example 22 The sustained release amount of Ca ions from the cured product of the dental cement of Example 2 shown in Table 1 was measured.
• the sustained release amount of Ca ions was measured by a method of measuring Ca ions eluted from the cured product of dental cement immersed in water by an ion electrode method.
• the dental cement of Example 2 shown in Table 1 was kneaded with a spatula for 30 seconds, and the kneaded product was placed in a mold having an inner diameter of 15 mm and a height of 1 mm. The mold was allowed to stand in a constant temperature and humidity chamber at 37 ° C. and 100% relative humidity for 1 hour from the end of kneading.
• the cured product was taken out from the mold to obtain a disk-shaped test piece.
• the mass of the test piece was measured, immersed in 5 ml of ion-exchanged water, and stored in a 37 ° C. incubator for 1 week. 10 ⁇ l of 5 mol / l hydrochloric acid, 15 ml of trishydroxyaminomethane buffer, and 1 ml of potassium chloride aqueous solution were added to the ion-exchanged water from which the test piece was taken out, and a compact water quality meter (LAQUAtwin-Ca-11, manufactured by Horiba Advanced Techno Co., Ltd.) was added. As a result of measuring the Ca ion concentration, the sustained release amount of Ca ions was 15600 ⁇ g / g.
• the sustained release amount of Ca ions was not suppressed by the dental cement containing Portland cement powder (A), cationic surfactant (B), and water (C), and the powder-liquid ratio was determined. It was shown that operability such as kneading property and filling is not affected easily, and a cured product having excellent operability and compressive strength can be obtained.
• the dental cement of the present invention can be suitably used as MTA cement, and can be used for diseases of the periodontal or apical periodontium such as root canal filling of teeth and direct pulp capping.

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• 2021
  • 2021-12-27 JP JP2022573095A patent/JP7735322B2/ja active Active
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  • 2021-12-27 US US18/269,799 patent/US20240082114A1/en active Pending
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