WO2022143458A1 - 一种应用于自动化分子诊断仪器的卡盒前处理系统 - Google Patents

一种应用于自动化分子诊断仪器的卡盒前处理系统 Download PDF

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Publication number
WO2022143458A1
WO2022143458A1 PCT/CN2021/141196 CN2021141196W WO2022143458A1 WO 2022143458 A1 WO2022143458 A1 WO 2022143458A1 CN 2021141196 W CN2021141196 W CN 2021141196W WO 2022143458 A1 WO2022143458 A1 WO 2022143458A1
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WO
WIPO (PCT)
Prior art keywords
cleaning
cartridge
swing
cassette
molecular diagnostic
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PCT/CN2021/141196
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English (en)
French (fr)
Inventor
王超
赵鹏
吴朋涛
潘洋
刘耀基
李振坤
刘聪
Original Assignee
安图实验仪器(郑州)有限公司
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Filing date
Publication date
Application filed by 安图实验仪器(郑州)有限公司 filed Critical 安图实验仪器(郑州)有限公司
Priority to US18/269,951 priority Critical patent/US20240069052A1/en
Priority to EP21914195.9A priority patent/EP4272881A4/en
Publication of WO2022143458A1 publication Critical patent/WO2022143458A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/02—Cleaning by the force of jets or sprays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00148—Test cards, e.g. Biomerieux or McDonnel multiwell test cards
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system

Definitions

  • the present application relates to the technical field of automated molecular diagnostic instruments, and more particularly, to a cartridge preprocessing system applied to automated molecular diagnostic instruments.
  • the barrier film on the top of the cartridge is punctured with a millitip or a membrane perforator.
  • the puncture used is a one-time product. , cannot be used twice. This method leads to high equipment cost, and generates more medical waste, which pollutes the environment.
  • the purpose of this application is to provide a cartridge pre-processing system applied to an automated molecular diagnostic instrument, which can clean the puncture device and reuse the puncture device, thereby reducing costs and medical waste.
  • a cartridge preprocessing system applied to an automated molecular diagnostic instrument comprising:
  • the puncturing device includes a driving component and a puncturing device, the driving component controls the puncturing device to alternately move to the puncturing station and the cleaning station, when the cartridge moves to the puncturing station, the The piercer pierces the barrier film of the cartridge;
  • the cleaning device is used for cleaning the puncturing device when the puncturing device moves to the cleaning station.
  • the puncture device includes a cylinder, the upper end of the cylinder is connected to the driving component, and the lower end of the cylinder is in the shape of a quadrangular pyramid.
  • the drive assembly includes a lift drive portion and a swing drive portion, the lift drive portion is connected to the swing drive portion and controls the swing drive portion to rise and fall, and the swing drive portion is connected to the puncture device and control the piercer to swing between the piercing station and the cleaning station.
  • the lift drive part includes a lift motor and a lift guide rail
  • the swing drive part includes a swing fixing base, a swing motor and a swing arm
  • the swing fixing base is fixed with the output end of the lift motor
  • the The swing fixing base is slidably matched with the lifting guide rail
  • the swing motor is installed on the swing fixing base
  • the output shaft of the swing motor is connected with the swing arm through a swing transmission assembly
  • the piercer is fixed to the swing arm. Swing arm.
  • the conveying device includes a casing and a pushing part, a conveying channel is arranged inside the casing, and the pushing part is used to push the cassette to move in the conveying passage, and the driving Both the assembly and the cleaning device are mounted on the housing, and the housing is provided with a piercing opening into which the piercing device is inserted.
  • it further includes an information scanning device for scanning the external label of the cassette, the information scanning device is mounted on the casing, and the casing is provided with a scanning notch for avoiding the information scanning device.
  • the housing is provided with a filling port for adding reagents to the cartridge.
  • the cleaning device includes a cleaning hole for placing the piercer, a cleaning liquid filling port for cleaning liquid to enter the cleaning hole, and a liquid drain channel for discharging the liquid in the cleaning hole.
  • the opening of the cleaning hole is upward, the cleaning hole is cylindrical, and the axis of the cleaning liquid filling port is spaced a preset distance from the center of the cleaning hole, so that the cleaning liquid is formed in the cleaning hole. vortex.
  • cleaning liquid filling ports there are at least two cleaning liquid filling ports, and all the cleaning liquid filling ports are sequentially distributed along the circumferential direction of the cleaning hole.
  • the cartridge pre-processing system applied to the automated molecular diagnostic instrument provided by this application includes a puncturing device and a cleaning device; the puncturing device includes a driving component and a puncturing device, and the driving component controls the puncturing device to alternately move to the puncturing station and clean station, when the cartridge moves to the piercing station, the piercer pierces the blocking film of the cartridge; when the piercer moves to the cleaning station, the cleaning device cleans the piercer.
  • the cartridge When in use, the cartridge is in the piercing position, and the drive assembly controls the piercer to pierce the blocking film of the cartridge at the piercing position. During this process, the piercer may adhere to the blocking film of the cartridge. If the attached reagent is not cleaned up, when the barrier film is repeatedly punctured, on the one hand, the reagent of the previous cartridge adhered to the puncture device will be mixed into the reagent of the next cartridge, which will affect the reagent of the next cartridge. The test results will be affected. On the other hand, the puncture will also mix the reagents in the current cartridge with other reagents in the current cartridge, resulting in abnormal test results of the current cartridge.
  • the driving component controls the puncture to move to the cleaning station, and the cleaning device is used to flush the puncture and remove the puncture. attached reagents.
  • the driving component drives the piercer back to the piercing station again.
  • the cartridge pretreatment system for an automated molecular diagnostic instrument uses a cleaning device to clean the puncture device, so that the puncture device can be reused, the use of consumables is reduced, the cost of users is reduced, and it is more environmentally friendly.
  • FIG. 1 is a schematic structural diagram of a cartridge pre-processing system applied to an automated molecular diagnostic instrument provided by an embodiment of the application;
  • FIG. 2 is a partial structural schematic diagram of a transmission device provided by an embodiment of the present application.
  • FIG. 3 is a schematic structural diagram of a puncturing device provided in an embodiment of the present application.
  • FIG. 4 is a schematic structural diagram of a puncture device provided in an embodiment of the present application.
  • FIG. 5 is a schematic structural diagram of a cleaning device provided by an embodiment of the present application.
  • FIG. 6 is a front cross-sectional view of the cleaning device shown in FIG. 5;
  • FIG. 7 is a plan cross-sectional view of the cleaning apparatus shown in FIG. 5 .
  • Conveyor 1 housing 11, channel 111, piercing port 112, filling port 113, guide 114, pusher 12, push motor 121, timing belt 122, push rail 123, slider 124, pusher 125, origin sensor 126 ;
  • Piercing device 2 piercing device 21, drive assembly 22, lift drive 221, lift motor 2211, lift guide 2212, swing drive 222, swing mount 2221, swing motor 2222, swing drive assembly 2223, swing arm 2224 ;
  • Cleaning device 3 cleaning hole 31 , cleaning liquid filling port 32 , drainage channel 33 ;
  • Information scanning device 4 Cartridge 5 .
  • the cartridge 5 generally includes a reaction chamber and a plurality of reagent wells.
  • a barrier film is provided on the top of each reagent well, and the reagents are individually sealed in their respective chambers. in the reagent well.
  • the reagents in each reagent well need to be put into the reaction chamber.
  • the barrier film on the top of the cassette 5 needs to be pierced first.
  • the cartridge pre-processing system for an automated molecular diagnostic instrument includes a puncturing device 2 and a cleaning device 3 .
  • the puncturing device 2 includes a driving component 22 and a puncturing device 21; wherein, the driving component 22 can adopt a mechanical arm or other driving structure, and the driving component 22 is connected with the puncturing device 21 and controls the puncturing device 21 to move, so that the The piercer 21 moves alternately to the piercing station and the cleaning station according to a preset path; the piercer 21 has a relatively sharp tip.
  • the piercer 21 uses its own structure to pierce the barrier film of the cassette 5.
  • the cleaning device 3 uses the cleaning liquid to clean the piercer 21 .
  • the cartridge pre-processing system is used in conjunction with the piercing device 2, the cleaning device 3, etc., so as to realize the relevant pre-processing function of the cartridge 5 before the test.
  • the cartridge pretreatment system pierces the barrier film through the piercer 21, which solves the problem that the top barrier film of the cartridge 5 is punctured before the reagent in the cartridge 5 is taken; at the same time, the cartridge pretreatment system also utilizes a cleaning device 3. Clean the piercer 21 so that the piercer 21 can be reused, thus reducing the use of consumables and the cost of the user.
  • the cartridge pre-processing system has a simple structure, is safe and reliable, has little system pollution risk, and is easy to maintain.
  • the puncture device 21 includes a cylinder, and the upper end of the cylinder is connected to the drive assembly 22 , such as the swing arm 2224 in the drive assembly 22 ; Quadrangular pyramid-shaped structure.
  • the reagent holes of the cartridge 5 are generally cylindrical, and the tops of the reagent holes are square.
  • the main body of the puncture device 21 adopts a cylindrical structure, and the diameter of the cylindrical body is adapted to the cross-sectional size of the reagent hole of the cartridge 5; Pyramid-shaped, the lower end of the piercer 21 corresponds to the square opening of the reagent hole of the cartridge 5, so as to ensure that after the barrier film is pierced, the tip of the piercer 21 can be aligned along the four side walls of the reagent hole, so that subsequent extractions can be performed. Reagent operation is not affected.
  • the piercer 21 should have a certain hardness, and it can be made of metal material.
  • the drive assembly 22 includes a lift drive part 221 and a swing drive part 222 , the lift drive part 221 is connected to the swing drive part 222 and controls the swing drive part 222 to rise and fall, the swing drive part 222 222 is connected with the piercer 21 and controls the piercer 21 to swing between the piercing station and the cleaning station. Specifically, by swinging, the piercer 21 can be moved away from the preset direction in which the cassette 5 is transported after completing the perforation operation, which is more convenient for arranging the cleaning device 3 in space.
  • the lift drive part 221 includes a lift motor 2211 and a lift guide rail 2212
  • the swing drive part 222 includes a swing fixing seat 2221 , a swing motor 2222 , a swing transmission assembly 2223 and a swing arm 2224
  • the lifting motor 2211 can be a screw motor
  • the swing fixing base 2221 is fixed with the output end of the lifting motor 2211
  • the swing fixing base 2221 is slidingly matched with the lifting guide rail 2212
  • the casing of the swing motor 2222 is fixedly connected with the swing fixing base 2221.
  • the output shaft of the swing motor 2222 is connected to the swing arm 2224 through a swing transmission assembly 2223 , which can be a coupling or a transmission belt or other transmission structures, and the piercer 21 is fixed to the swing arm 2224 .
  • the lift motor 2211 controls the swing driving part 222 and the piercer 21 to move up and down as a whole, and the starting position and ending position of the movement can be detected by sensors and controlled by electronic control.
  • the cassette pre-processing system applied to the automated molecular diagnostic instrument further includes a conveying device 1, and the conveying device 1 is used to control the movement of the cassette 5.
  • the conveying device 1 can control the cassette 5. Move to the puncturing station, or control the cassette 5 to move from the puncturing station to the cleaning station, or control the cassette 5 to move from the cleaning station to the subsequent processing station.
  • the conveying device 1 includes a casing 11 and a pushing portion 12 , a conveying channel 111 is provided inside the casing 11 , and the pushing portion 12 is used to push the cassette 5 to move in the conveying passage 111 .
  • the driving assembly 22 and the cleaning device 3 are both mounted on the casing 11 , and the casing 11 is provided with a puncturing opening 112 into which the puncturing device 21 is inserted.
  • the casing 11 encapsulates the cartridge 5 in its own internal channel 111 , and the casing 11 may be provided with a guide member 114 to provide a guiding function for the movement of the cartridge 5 .
  • the casing 11 has a piercing opening 112 for the piercer 21 to pass through, so as to realize the piercing of the barrier film.
  • the pushing part 12 includes a pushing motor 121 , a driven wheel, a synchronous belt 122 , a pushing guide rail 123 , a slider 124 and a pushing handle 125 .
  • the push motor 121 can be a stepper motor, the drive shaft of the push motor 121 and the driven wheel are connected by the synchronous belt 122, the push guide rail 123 is fixed on the housing 11, the slider 124 is slidingly matched with the push guide rail 123, and the slider 124 is synchronized with the The belt 122 and the push handle 125 are fixedly connected, and the push handle 125 can be embedded in the middle of the cassette 5 and push the cassette 5 to move.
  • the motor 121 is pushed to rotate, and the pusher 125 is driven by the synchronous belt 122 to move, and the pusher 125 pushes the cassette 5 to move in a preset direction in the channel 111, thereby controlling the cassette 5 to move to various functional positions, such as the cassette 5 information Read position, reagent filling position, puncture position, and realize related functions.
  • various functional positions such as the cassette 5 information Read position, reagent filling position, puncture position, and realize related functions.
  • the cassette 5 completes the information reading, reagent filling, and barrier film piercing in the channel 111
  • the movement of the pusher 125 is controlled by the pusher motor 121, and the starting position and the ending position of the movement can be detected by the origin sensor 126 and the limit sensor, respectively, and controlled in combination with the electric control.
  • the transfer device 1 can also control the movement of the cassette 5 by other means in the prior art.
  • the transfer device 1 employs a robot.
  • the cartridge preprocessing system applied to the automated molecular diagnostic instrument further includes an information scanning device 4 , and the information scanning device 4 is used to scan the labels outside the cartridge 5 .
  • a label is generally provided on the outside of the cassette 5, and the label stores information including the type of the cassette 5, manufacturing information, serial number, validity period, instruction manual, etc. etc. to be stored in a machine-readable way.
  • the information scanning device 4 is a code reader, and the code reader can be a device capable of reading barcodes or two-dimensional codes, or a device capable of reading radio frequency identification identifiers.
  • the information scanning device 4 Before the sample is processed, when the system loads the cassette 5, the information scanning device 4 reads the information on the label of the cassette 5 in advance, so that the information can be transmitted in the system, which solves the problem of reading the information on the cassette 5 into the system and Problems passed in the system.
  • the information scanning device 4 may be specifically installed on the housing 11 , and correspondingly, the housing 11 is provided with a code scanning gap for avoiding the information scanning device 4 .
  • the housing 11 is provided with a filling port 113 , through which the reagent can be added to the cartridge 5 .
  • the cleaning device 3 includes a cleaning hole 31 , a cleaning liquid filling port 32 and a liquid draining channel 33 .
  • the cleaning hole 31 is used to place the puncture device 21, the cleaning liquid filling port 32 and the liquid draining channel 33 are respectively connected with the cleaning hole 31, and the cleaning liquid filling port 32 is for the cleaning liquid to enter the cleaning hole 31, and the liquid discharge flow
  • the channel 33 is for draining the liquid in the cleaning hole 31 .
  • the cleaning liquid filling port 32 needs to be connected to the cleaning container through a pipeline, and is equipped with a power source for driving the flow of the cleaning liquid.
  • the power source can be a diaphragm pump or a peristaltic pump. achieve cleaning effect.
  • the opening of the cleaning hole 31 is upward, the cleaning hole 31 is cylindrical, and the cleaning liquid filling port 32 is connected to the cleaning hole 31 from the side of the cleaning hole 31 . Connected. On the projection along the axial direction of the cleaning hole 31 , the axis of the cleaning liquid filling port 32 is spaced a predetermined distance from the center of the cleaning hole 31 . Specifically, the cleaning liquid filling port 32 extends along the secant direction of the cleaning hole 31 , and the secant line is not a diameter, that is, the cleaning liquid filling port 32 and the center of the cleaning hole 31 are offset to a certain extent, rather than facing each other. The center of the hole 31 is cleaned. With this structure, after the cleaning liquid is injected into the cleaning hole 31 , a vortex will be formed in the cleaning hole 31 , so that the piercer 21 can be cleaned better.
  • the plurality of cleaning liquid filling ports 32 will further promote the cleaning liquid to form a turbine and optimize the cleaning effect.
  • the number of cleaning liquid filling ports 32 is two.
  • the pusher 125 pushes the cassette 5 into the channel 111 until the label affixed to the side of the cassette 5 faces the information scanning device 4 , and the information scanning device 4 reads the information on the label of the cassette 5 .
  • the conveying device 1 will push the cassette 5 to move forward until the reaction chamber on the cassette 5 is directly opposite to the filling hole, and the reagent filling device will store the reagents stored in the instrument at this position. Reagents in the zone are filled.
  • the pusher 125 After reading the information of the cartridge 5, the pusher 125 continues to push the cartridge 5 forward along the channel 111 of the housing 11 until the reagent hole covered by the barrier film is aligned with the puncture opening 112 under the puncture device 21, and the motor is lifted and lowered. 2211 drives the piercer 21 to move downward, and pierces the barrier film on the cartridge 5 through the tip of the piercer 21 . There is a certain space between the liquid level in the reagent hole of the cassette 5 and the blocking film on the top of the cassette 5. When the puncture device 21 pierces the blocking film on the top of the cassette 5, the lower end of the puncturing device 21 will not be in contact with the cassette. 5 The reagents in the reagent wells are in contact.
  • the tip of the piercer 21 may adhere to the reagent attached to the barrier film, when piercing again, if the piercer 21 is not cleaned, the piercer 21 will not be cleaned.
  • the adhered reagents will be mixed into the reagents of the next cartridge 5, affecting the test result of the next cartridge 5; or the reagents in the reagent wells of the same cartridge 5 will be mixed, resulting in abnormal test results of the current cartridge 5. Therefore, after the barrier film on the upper part of the cartridge 5 is pierced, the tip portion of the piercer 21 needs to be cleaned.
  • the lift motor 2211 drives the piercer 21 to move upward.
  • the piercer 21 is driven by the swing driving part 222 to swing to the cleaning hole.
  • the lifting motor 2211 drives the piercer 21 to move downward until the piercer 21 enters the cleaning hole 31 of the cleaning device 3, and the power source acts to draw out the cleaning liquid in the cleaning container, and the cleaning liquid passing through the cleaning device 3
  • the filling port 32 cleans the tip of the piercer 21 .
  • the lift motor 2211 rotates again to raise the puncture device 21 until the tip of the puncture device 21 is higher than the top of the channel 111 , and the swing driving part 222 runs again to drive the puncture device 21 to the position above the puncture opening 112 again.
  • the transfer device 1 pushes the cartridge 5 forward again until the next reagent hole on the cartridge 5 is aligned with the piercing opening 112, the piercing device 2 and the cleaning device 3 will enter the next cycle until the cartridge 5 The barrier film on top was all punctured.
  • the pushing motor 121 in the pushing part 12 of the conveying device 1 is reversed to push the cassette 5 out of the channel 111, and the cassette 5 is pushed into the bottom under the action of the conveying device 1. An operating position for subsequent operations.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
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  • General Physics & Mathematics (AREA)
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Abstract

一种应用于自动化分子诊断仪器的卡盒前处理系统，包括刺破装置和清洗装置，刺破装置包括驱动组件和刺破器，驱动组件控制刺破器交替移动至刺破工位和清洗工位。当卡盒移动到刺破工位，刺破器将卡盒的阻挡膜刺破；当刺破器移动到清洗工位，清洗装置对刺破器进行清洗。本申请提供的应用于自动化分子诊断仪器的卡盒前处理系统利用清洗装置将刺破器清洗干净，使得刺破器可以重复使用，减少了耗材的使用，降低了用户的成本，也更加环保。

Description

一种应用于自动化分子诊断仪器的卡盒前处理系统
本申请要求于2020年12月29日提交中国专利局、申请号为202011601452.7、发明名称为“一种应用于自动化分子诊断仪器的卡盒前处理系统”的中国专利申请的优先权，其全部内容通过引用结合在本申请中。
技术领域
本申请涉及自动化分子诊断仪器技术领域，更具体地说，涉及一种应用于自动化分子诊断仪器的卡盒前处理系统。
背景技术
目前，自动化分子诊断仪器在使用过程中，卡盒顶部的阻挡膜采用毫尖端或者膜穿孔器进行刺破，为了避免卡盒内部的试剂出现交叉污染，所采用的刺破器均为一次性产品，不能二次使用。该种方式导致设备成本高，并且产生更多的医疗废弃物，对环境造成污染。
综上所述，如何提供一种刺破器可重复使用的卡盒前处理系统，是目前本领域技术人员亟待解决的问题。
发明内容
有鉴于此，本申请的目的是提供一种应用于自动化分子诊断仪器的卡盒前处理系统，其能够将刺破器清洗干净，使刺破器重复使用，从而降低了成本，减少了医疗废物。
为了实现上述目的，本申请提供如下技术方案：
一种应用于自动化分子诊断仪器的卡盒前处理系统，包括：
刺破装置，包括驱动组件和刺破器，所述驱动组件控制所述刺破器交替移动至刺破工位和清洗工位，当所述卡盒移动到所述刺破工位，所述刺破器将所述卡盒的阻挡膜刺破；
清洗装置，用于当所述刺破器移动到所述清洗工位，对所述刺破器进行清洗。
可选的，所述刺破器包括柱体，所述柱体的上端与所述驱动组件连接，所述柱体的下端呈四棱锥状结构。
可选的，所述驱动组件包括升降驱动部和摆动驱动部，所述升降驱动部与所述摆动驱动部连接并控制所述摆动驱动部升降，所述摆动驱动部与所述刺破器连接并控制所述刺破器在所述刺破工位和所述清洗工位之间摆动。
可选的，所述升降驱动部包括升降电机和升降导轨，所述摆动驱动部包括摆动固定座、摆动电机和摆臂，所述摆动固定座与所述升降电机的输出端固定，且所述摆动固定座与所述升降导轨滑动配合，所述摆动电机安装于所述摆动固定座，所述摆动电机的输出轴通过摆动传动组件与所述摆臂连接，所述刺破器固定于所述摆臂。
可选的，还包括传送装置，所述传送装置包括外壳和推动部，所述外壳的内部设有传送通道，所述推动部用于推动所述卡盒在所述传送通道中移动，所述驱动组件和所述清洗装置均安装于所述外壳，所述外壳设有供所述刺破器伸入的刺破口。
可选的，还包括用于扫描所述卡盒外部标签的信息扫描装置，所述信息扫描装置安装于所述外壳，所述外壳设有避让所述信息扫描装置的扫码缺口。
可选的，所述外壳设有用于向所述卡盒添加试剂的加注口。
可选的，所述清洗装置包括用于放置所述刺破器的清洗孔、供清洗液进入所述清洗孔中的清洗液加注口以及供所述清洗孔中液体排出的排液流道。
可选的，所述清洗孔的开口朝上，清洗孔呈圆柱状，所述清洗液加注口的轴线与所述清洗孔的圆心间隔预设距离，以便清洗液在所述清洗孔中形成涡流。
可选的，所述清洗液加注口至少有两个，全部所述清洗液加注口沿所述清洗孔的周向依次分布。
通过上述方案，本申请提供的应用于自动化分子诊断仪器的卡盒前处 理系统的有益效果在于：
本申请提供的应用于自动化分子诊断仪器的卡盒前处理系统包括刺破装置和清洗装置；刺破装置包括驱动组件和刺破器，驱动组件控制刺破器交替移动至刺破工位和清洗工位，当卡盒移动到刺破工位，刺破器将卡盒的阻挡膜刺破；当刺破器移动到清洗工位，清洗装置对刺破器进行清洗。
在使用时，卡盒处于刺破工位，驱动组件控制刺破器在刺破工位将卡盒的阻挡膜刺破，在此过程中，刺破器可能会粘附上卡盒阻挡膜上附着的试剂，若不进行清理，在后续重复刺破阻挡膜时，一方面，刺破器上粘附的上一个卡盒的试剂会混入下一个卡盒的试剂中，对下一个卡盒的测试结果造成影响，另一方面，刺破器也会将当前卡盒中的试剂混入当前卡盒中的其他试剂中，造成当前卡盒的测试结果异常。
本申请中的应用于自动化分子诊断仪器的卡盒前处理系统，在一次刺破完成后，驱动组件控制刺破器移动至清洗工位，利用清洗装置对刺破器进行冲洗，清除刺破器上附着的试剂。当再次需要刺破下一个阻挡膜时，驱动组件再次带动刺破器回到刺破工位。
本申请提供的应用于自动化分子诊断仪器的卡盒前处理系统利用清洗装置将刺破器清洗干净，使得刺破器可以重复使用，减少了耗材的使用，降低了用户的成本，也更加环保。
附图说明
为了更清楚地说明本申请实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本申请的实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据提供的附图获得其他的附图。
图1为本申请实施例提供的一种应用于自动化分子诊断仪器的卡盒前处理系统的结构示意图；
图2为本申请实施例提供的一种传送装置的部分结构示意图；
图3为本申请实施例提供的一种刺破装置的结构示意图；
图4为本申请实施例提供的一种刺破器的结构示意图；
图5为本申请实施例提供的一种清洗装置的结构示意图；
图6为图5所示的清洗装置的主视剖视图；
图7为图5所示的清洗装置的俯视剖视图。
图中的附图标记为：
传送装置1、外壳11、通道111、刺破口112、加注口113、引导件114、推动部12、推动电机121、同步带122、推动导轨123、滑块124、推手125、原点传感器126；刺破装置2、刺破器21、驱动组件22、升降驱动部221、升降电机2211、升降导轨2212、摆动驱动部222、摆动固定座2221、摆动电机2222、摆动传动组件2223、摆臂2224；清洗装置3、清洗孔31、清洗液加注口32、排液流道33；信息扫描装置4；卡盒5。
具体实施方式
下面将结合本申请实施例中的附图，对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本申请一部分实施例，而不是全部的实施例。基于本申请中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本申请保护的范围。
卡盒5一般包括反应仓和多个试剂孔，为了试剂能更好的储存，并防止卡盒5内的试剂产生交叉污染，各个试剂孔的顶部均设置有阻挡膜，将试剂单独密封在各自的试剂孔内。在使用时，需要将各个试剂孔内的试剂放入反应仓中。为了取用卡盒5内各个试剂孔内的试剂，需先将卡盒5顶部的阻挡膜刺破。
请参考图1，本申请提供的应用于自动化分子诊断仪器的卡盒前处理系统包括刺破装置2和清洗装置3。
具体的，刺破装置2包括驱动组件22和刺破器21；其中，驱动组件22可以采用机械臂或者其他驱动结构，驱动组件22与刺破器21连接，并控制刺破器21移动，使得刺破器21按照预设路径交替移动至刺破工位和清洗工位；刺破器21具有较为锋利的尖端。
上述结构的卡盒前处理系统在工作过程中，当刺破器21在驱动组件 22的控制下移动到刺破工位，刺破器21利用自身结构将卡盒5的阻挡膜刺破。当刺破器21移动到清洗工位，清洗装置3利用清洗液对刺破器21进行清洗。该卡盒前处理系统通过刺破装置2、清洗装置3等配合使用，实现测试前对卡盒5进行相关的前处理功能。该卡盒前处理系统通过刺破器21刺破阻挡膜，解决了取用卡盒5内试剂前，卡盒5顶部阻挡膜刺破的问题；同时，该卡盒前处理系统还利用清洗装置3将刺破器21清洗干净，使得刺破器21可以重复使用，因此减少了耗材的使用，降低了用户的成本。并且该卡盒前处理系统结构简单，安全可靠，系统污染风险小，同时便于维护。
进一步的，在一种实施例中，请参考图4，刺破器21包括柱体，柱体的上端与驱动组件22连接，如具体连接驱动组件22中的摆臂2224；柱体的下端呈四棱锥状结构。具体的，卡盒5的试剂孔一般采用圆柱状，且试剂孔的顶部为正方形。相应的，刺破器21的主体采用圆柱体结构，柱体的直径与卡盒5的试剂孔的截面大小相适应；刺破器21的下端采用四方形斜切结构，即具有尖角的四棱锥状，刺破器21的下端与卡盒5的试剂孔的四方形开口相对应，保证阻挡膜刺破后，刺破器21的尖端能够沿试剂孔的四侧壁贴齐，使后续取试剂操作不受影响。刺破器21应当具有一定的硬度，其可以采用金属材质制成。
进一步的，在一种实施例中，请参考图3，驱动组件22包括升降驱动部221和摆动驱动部222，升降驱动部221与摆动驱动部222连接并控制摆动驱动部222升降，摆动驱动部222与刺破器21连接并控制刺破器21在刺破工位和清洗工位之间摆动。具体的，采用摆动的方式，可以使得刺破器21完成穿孔作业后远离卡盒5传送的预设方向，更方便在空间上布置清洗装置3。
进一步的，在一种实施例中，升降驱动部221包括升降电机2211和升降导轨2212，摆动驱动部222包括摆动固定座2221、摆动电机2222、摆动传动组件2223和摆臂2224。其中，升降电机2211可以采用丝杆电机，摆动固定座2221与升降电机2211的输出端固定，且摆动固定座2221与升降导轨2212滑动配合，摆动电机2222的机壳与摆动固定座2221固定连接， 摆动电机2222的输出轴通过摆动传动组件2223与摆臂2224连接，摆动传动组件2223可以为联轴器或者传动带或者其他传动结构，刺破器21固定于摆臂2224。在工作时，升降电机2211控制摆动驱动部222和刺破器21整体上下移动，移动的起始位置和终止位置可以分别通过传感器来检测并结合电控进行控制。
可选的，在一种实施例中，应用于自动化分子诊断仪器的卡盒前处理系统还包括传送装置1，传送装置1用于控制卡盒5移动，例如，传送装置1可以控制卡盒5移动到刺破工位，或者控制卡盒5从刺破工位移动至清洗工位，或者控制卡盒5从清洗工位移动至后续处理工位。
可选的，在一种实施例中，传送装置1包括外壳11和推动部12，外壳11的内部设有传送通道111，推动部12用于推动卡盒5在传送通道111中移动。驱动组件22和清洗装置3均安装于外壳11，外壳11设有供刺破器21伸入的刺破口112。具体的，外壳11将卡盒5封装在自身内部通道111中，外壳11可以设置引导件114来为卡盒5的移动提供导向作用。外壳11开设刺破口112，供刺破器21穿过，实现阻挡膜的刺破。
可选的，在一种实施例中，请参考图2，推动部12包括推动电机121、从动轮、同步带122、推动导轨123、滑块124以及推手125。其中，推动电机121可以采用步进电机，推动电机121的驱动轴和从动轮通过同步带122连接，推动导轨123固定于外壳11，滑块124与推动导轨123滑动配合，滑块124同时与同步带122和推手125固定连接，推手125可嵌入卡盒5的中部并推动卡盒5移动。在工作时，推动电机121旋转，通过同步带122带动推手125运动，推手125推动卡盒5在通道111内沿预设方向运动，从而控制卡盒5移动到各个功能位置，如卡盒5信息读取位置、试剂加注位置、刺破位置，实现相关功能。然后，当卡盒5在通道111内完成卡盒5信息读取、试剂加注、阻挡膜刺破后，通过推动电机121反转，带动卡盒5在通道111内反向运动，退出通道111，进行相关测试的后续工作。推手125的移动由推动电机121控制，移动的起始位置和终止位置可以分别通过原点传感器126和限位传感器来检测，并结合电控进行控制。
可以理解的，传送装置1也可以通过现有技术中的其他手段控制卡盒 5移动。例如，传送装置1采用机械手。
进一步的，在一种实施例中，应用于自动化分子诊断仪器的卡盒前处理系统还包括信息扫描装置4，信息扫描装置4用于扫描卡盒5外部的标签。具体的，卡盒5的外部一般设置有标签，该标签上储存有包括卡盒5类型、制造信息、序列号、有效期、使用说明书等信息，主要采用诸如条形码、二维码、射频识别标识符等机器可读取的方式来存储。信息扫描装置4为读码器，该读码器可采用能够读取条形码或者二维码的装置，也可以采用能够读取射频识别标识符的装置。在样本处理之前，系统载入卡盒5时，信息扫描装置4预先对卡盒5标签上的信息进行读取，以便信息能在系统内传递，解决了将卡盒5上信息读入系统并在系统中传递的问题。在实际布置时，信息扫描装置4可以具体安装于外壳11，相应的，外壳11设有避让信息扫描装置4的扫码缺口。
进一步的，在一种实施例中，外壳11设有加注口113，通过加注口113可以向卡盒5添加试剂。
进一步的，在一种实施例中，请参考图5和图6，清洗装置3包括清洗孔31、清洗液加注口32和排液流道33。其中，清洗孔31用于放置刺破器21，清洗液加注口32和排液流道33分别与清洗孔31连通，清洗液加注口32供清洗液进入清洗孔31中，排液流道33供清洗孔31中液体排出。在使用时，清洗液加注口32需要通过管路连接清洗容器，并配备驱动清洗液流动的动力源，动力源可以为隔膜泵或者蠕动泵，通过流动的清洗液持续冲洗刺破器21，达到清洁效果。
进一步的，在一种实施例中，请参考图6和图7，清洗孔31的开口朝上，清洗孔31呈圆柱状，清洗液加注口32从清洗孔31的侧部与清洗孔31连通。在沿清洗孔31轴向的投影上，清洗液加注口32的轴线与清洗孔31的圆心间隔预设距离。具体的，清洗液加注口32沿清洗孔31的割线方向延伸，且该割线非直径，即，清洗液加注口32与清洗孔31的中心有一定的偏移，而非正对清洗孔31的中心。采用该种结构，清洗液加注到清洗孔31内后会在清洗孔31内形成涡流，便于更好的将刺破器21清洗干净。
进一步的，在一种实施例中，清洗液加注口32至少有两个，全部清洗 液加注口32沿清洗孔31的周向依次分布。具体的，多个清洗液加注口32会进一步促进清洗液形成涡轮，优化清洁效果。优选清洗液加注口32的数量为两个。
上述结构的应用于自动化分子诊断仪器的卡盒前处理系统的工作流程如下：
推手125将卡盒5推入通道111内，直到粘贴在卡盒5侧面的标签与信息扫描装置4正对时，信息扫描装置4对卡盒5标签上的信息进行读取。
卡盒5信息读取完成后，传送装置1会推动卡盒5继续前进，直到卡盒5上的反应仓与加注孔正对时，由试剂加注装置在此位置对储存于仪器试剂存储区的试剂进行加注。
读取卡盒5信息后，推手125将卡盒5沿着外壳11的通道111继续向前推动，直到被阻挡膜覆盖的试剂孔与刺破器21下方的刺破口112对准时，升降电机2211带动刺破器21向下运动，通过刺破器21的尖端部分将卡盒5上的阻挡膜刺破。卡盒5试剂孔内的液面与卡盒5顶部的阻挡膜之间有一定的空间，当刺破器21刺破卡盒5顶部阻挡膜后，刺破器21的下端不会与卡盒5试剂孔内的试剂相接触。
卡盒5试剂孔的阻挡膜刺破后，由于刺破器21的尖端部分可能粘附阻挡膜上附着的试剂，再次进行刺破时，若不对刺破器21进行清洗，刺破器21上粘附的试剂会混入下一个卡盒5的试剂中，影响下一个卡盒5的测试结果；或者造成同一卡盒5的各试剂孔内的试剂混合，造成当前卡盒5的测试结果异常。因此卡盒5上部的阻挡膜被刺破后，需对刺破器21的尖端部分进行清洗。
卡盒5阻挡膜被刺破后，升降电机2211带动刺破器21向上运动，当刺破器21尖端部分完全运动到通道111上方时，通过摆动驱动部222驱动刺破器21摆动到清洗孔31上方，升降电机2211带动刺破器21向下运动，直到刺破器21进入到清洗装置3的清洗孔31内，动力源动作将清洗容器内的清洗液抽出，经清洗装置3的清洗液加注口32对刺破器21的尖端进行清洗。清洗完毕后，升降电机2211再次旋转将刺破器21升起，直到刺破器21尖端高于通道111顶部，摆动驱动部222再次运行，再次将刺破器 21带动到刺破口112上方位置，然后传送装置1将卡盒5再次向前推动，直到卡盒5上的下一个试剂孔与刺破口112对准，刺破装置2和清洗装置3会进入下一个循环，直到卡盒5顶部的阻挡膜全部被刺破。
当卡盒5顶部的阻挡膜被全部刺破，传送装置1的推动部12中的推动电机121反转，将卡盒5推出通道111，在传送装置1作用下将卡盒5推入到下一个操作位置进行后续的操作。
本说明书中各个实施例采用递进的方式描述，每个实施例重点说明的都是与其他实施例的不同之处，各个实施例之间相同相似部分互相参见即可。
以上对本申请所提供的应用于自动化分子诊断仪器的卡盒前处理系统进行了详细介绍。本文中应用了具体个例对本申请的原理及实施方式进行了阐述，以上实施例的说明只是用于帮助理解本申请的方法及其核心思想。应当指出，对于本技术领域的普通技术人员来说，在不脱离本申请原理的前提下，还可以对本申请进行若干改进和修饰，这些改进和修饰也落入本申请权利要求的保护范围内。

Claims (10)

  1. 一种应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，包括：
    刺破装置(2)，包括驱动组件(22)和刺破器(21)，所述驱动组件(22)控制所述刺破器(21)交替移动至刺破工位和清洗工位，当所述卡盒(5)移动到所述刺破工位，所述刺破器(21)将所述卡盒(5)的阻挡膜刺破；
    清洗装置(3)，用于当所述刺破器(21)移动到所述清洗工位，对所述刺破器(21)进行清洗。
  2. 根据权利要求1所述的应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，所述刺破器(21)包括柱体，所述柱体的上端与所述驱动组件(22)连接，所述柱体的下端呈四棱锥状结构。
  3. 根据权利要求1所述的应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，所述驱动组件(22)包括升降驱动部(221)和摆动驱动部(222)，所述升降驱动部(221)与所述摆动驱动部(222)连接并控制所述摆动驱动部(222)升降，所述摆动驱动部(222)与所述刺破器(21)连接并控制所述刺破器(21)在所述刺破工位和所述清洗工位之间摆动。
  4. 根据权利要求3所述的应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，所述升降驱动部(221)包括升降电机(2211)和升降导轨(2212)，所述摆动驱动部(222)包括摆动固定座(2221)、摆动电机(2222)和摆臂(2224)，所述摆动固定座(2221)与所述升降电机(2211)的输出端固定，且所述摆动固定座(2221)与所述升降导轨(2212)滑动配合，所述摆动电机(2222)安装于所述摆动固定座(2221)，所述摆动电机(2222)的输出轴通过摆动传动组件(2223)与所述摆臂(2224)连接，所述刺破器(21)固定于所述摆臂(2224)。
  5. 根据权利要求1所述的应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，还包括传送装置(1)，所述传送装置(1)包括外壳(11)和推动部(12)，所述外壳(11)的内部设有传送通道(111)，所述推动部(12)用于推动所述卡盒(5)在所述传送通道(111)中移动，所述驱动组件(22)和所述清洗装置(3)均安装于所述外壳(11)，所述外壳(11) 设有供所述刺破器(21)伸入的刺破口(112)。
  6. 根据权利要求5所述的应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，还包括用于扫描所述卡盒(5)外部标签的信息扫描装置(4)，所述信息扫描装置(4)安装于所述外壳(11)，所述外壳(11)设有避让所述信息扫描装置(4)的扫码缺口。
  7. 根据权利要求5所述的应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，所述外壳(11)设有用于向所述卡盒(5)添加试剂的加注口(113)。
  8. 根据权利要求1至7任意一项所述的应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，所述清洗装置(3)包括用于放置所述刺破器(21)的清洗孔(31)、供清洗液进入所述清洗孔(31)中的清洗液加注口(32)以及供所述清洗孔(31)中液体排出的排液流道(33)。
  9. 根据权利要求8所述的应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，所述清洗孔(31)的开口朝上，清洗孔(31)呈圆柱状，所述清洗液加注口(32)的轴线与所述清洗孔(31)的圆心间隔预设距离，以便清洗液在所述清洗孔(31)中形成涡流。
  10. 根据权利要求9所述的应用于自动化分子诊断仪器的卡盒前处理系统，其特征在于，所述清洗液加注口(32)至少有两个，全部所述清洗液加注口(32)沿所述清洗孔(31)的周向依次分布。
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