WO2022139502A1 - 신규한 사카로미세스 세레비시에 균주 및 이의 용도 - Google Patents
신규한 사카로미세스 세레비시에 균주 및 이의 용도 Download PDFInfo
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- WO2022139502A1 WO2022139502A1 PCT/KR2021/019700 KR2021019700W WO2022139502A1 WO 2022139502 A1 WO2022139502 A1 WO 2022139502A1 KR 2021019700 W KR2021019700 W KR 2021019700W WO 2022139502 A1 WO2022139502 A1 WO 2022139502A1
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- Prior art keywords
- strain
- saccharomyces cerevisiae
- present
- skin
- culture
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- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
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- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- 239000001294 propane Substances 0.000 description 1
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- 235000013772 propylene glycol Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000004492 retinoid derivatives Chemical class 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- 239000008234 soft water Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- JBQYATWDVHIOAR-UHFFFAOYSA-N tellanylidenegermanium Chemical compound [Te]=[Ge] JBQYATWDVHIOAR-UHFFFAOYSA-N 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 238000011514 vinification Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000007222 ypd medium Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
- C12N1/185—Saccharomyces isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/845—Rhizopus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/85—Saccharomyces
- C12R2001/865—Saccharomyces cerevisiae
Definitions
- the present invention is Saccharomyces cerevisiae deposited with the accession number KCTC 14268BP ( Saccharomyces cerevisiae ) strain; A cosmetic composition, a quasi-drug composition, or a food composition comprising at least one selected from the group consisting of the strain, the culture of the strain, and the fermented product of the strain; Skin improvement method using the strain, the culture of the strain, and the fermented product of the strain; And it relates to a skin improvement use using the strain, the culture of the strain, and the fermented product of the strain.
- retinoid, adenosine, animal placenta-derived protein, and chlorella extract are known as skin elasticity enhancement and wrinkle improvement cosmetics.
- Retinol the most widely known, has limited usage due to safety issues such as irritation when applied to the skin, and chlorella extract has insignificant effects, making it difficult to actually expect skin elasticity enhancement and wrinkle improvement effects.
- commonly known whitening ingredients include kojic acid or arbutin, hydroquinone, vitamin C or derivatives thereof, and various plant extracts.
- kojic acid or arbutin hydroquinone
- vitamin C or derivatives thereof various plant extracts
- the present inventors have conducted research on raw materials that are safer and have an excellent skin improvement effect from natural resources, and Saccharomyces cerevisiae has a skin improvement effect, and in particular, Saccharomyces cerevisiae newly discovered from the Saccharomyces cerevisiae flower
- Saccharomyces cerevisiae newly discovered from the Saccharomyces cerevisiae flower
- the present invention was completed by confirming that the skin improvement effect was significantly superior to that of other Saccharomyces cerevisiae strains.
- One object of the present invention is to provide a Saccharomyces cerevisiae strain deposited with accession number KCTC 14268BP.
- Another object of the present invention is to provide a cosmetic composition for skin improvement comprising any one or more of the strain, the culture of the strain, and the fermented product of the strain.
- Another object of the present invention is to provide a quasi-drug composition for skin improvement comprising any one or more of the strain, the culture of the strain, and the fermented product of the strain.
- Another object of the present invention is to provide a food composition for skin improvement comprising any one or more of the strain, the culture of the strain, and the fermented product of the strain
- Another object of the present invention is to provide a skin improvement method using any one or more of the strain, the culture of the strain, and the fermented product of the strain.
- Another object of the present invention is to provide a skin improvement use of any one or more of the strain, the culture of the strain, and the fermented product of the strain.
- the culture of the strain, or the fermented product of the strain has an excellent skin improvement effect, it has high utility as a cosmetic composition for skin improvement and a quasi-drug composition. Accordingly, various industrial applications such as cosmetics and quasi-drugs can be expected.
- One aspect of the present invention provides a Saccharomyces cerevisiae strain deposited with accession number KCTC 14268BP.
- Saccharomyces cerevisiae refers to a species of yeast belonging to the genus Saccharomycetaceae and Saccharomyces. This species has been widely used since ancient times, playing an important role in winemaking, baking, and brewing. Saccharomyces cerevisiae has different characteristics depending on the growth region and natural environmental conditions, so the strain and its fermented product activity may vary, and Saccharomyces cerevisiae of the present invention may be derived from Dendrobium candidum . , but not limited thereto.
- Dendrobium candidum is one of the Orchidaceae plants widely known as traditional medicinal plants. Since ancient times, the stems of cheolpiseokgok have been widely used for medicinal purposes. It is cylindrical, 15-50 cm long, 0.15 to 0.3 cm in diameter, and 1 to 4 cm between nodes. The outer surface is yellow, and the lower part is glossy and has vertical wrinkles. There are inflorescence stalk marks and remaining leaf sheaths on the nodes, and the leaf sheath's entrance is open.
- the ferrite grains of the present invention may be purchased and used commercially, or those harvested or cultivated in nature may be used.
- the Saccharomyces cerevisiae of the present invention may be derived from pyrophycetes, and the plant parts may be specifically selected and used for the flower parts, so the Saccharomyces cerevisiae may be derived from the ferrets, but the parts, It is not limited to the origin and method of obtaining.
- the fermented product of Saccharomyces cerevisiae KCTC 14268BP has a skin improvement effect. was confirmed to be excellent.
- Another aspect of the present invention is a Saccharomyces cerevisiae deposited with accession number KCTC 14268BP, a culture of the strain, and a cosmetic composition for skin improvement comprising any one or more of a fermented product of the strain provides
- the culture of the present invention means a culture solution obtained by culturing a specific microorganism in a culture medium, a concentrated culture solution, a dried product of a culture solution, a culture filtrate, a concentrated culture filtrate, or a dried product of a culture filtrate, and the culture solution is a specific microorganism. It means to include, and the culture filtrate is substantially free of specific bacteria (herein, it means that the specific bacteria is substantially excluded by filtration, etc., and does not mean that the bacteria are completely excluded in the filtrate). means not including.
- the culture is not limited in its formulation, and may be, for example, a liquid, an emulsion, or a solid.
- fertilization means that microorganisms are not putrefactive during the process of decomposing organic matter using their own enzymes. Fermentation reaction and decay reaction proceed by similar processes, but when decomposition produces useful substances, it is called fermentation, and when odorous or harmful substances are produced, it is called spoilage.
- the method for obtaining the fermented product from the strain is not particularly limited, and may be obtained according to a method commonly used in the art or similar fields.
- the fermented product obtained from the strain is not only the fermented material itself, but also the culture medium of the strain and the culture coexisting, the fermented product obtained by filtering the strain from the culture medium, and sterilizing the strain from the culture medium and
- the fermented product or an extract obtained by extracting the culture medium containing the same By collecting the filtered fermented product, the fermented product or an extract obtained by extracting the culture medium containing the same, the diluted solution obtained by diluting the fermented product or its extract, the concentrated solution, the dried product obtained by drying the fermented product or the extract thereof, and the cells of the strain.
- All kinds of substances including fermented products generated from the above strains, such as crushed lysates, are included.
- the skin improvement may be any one or more selected from the group consisting of skin moisturizing, wrinkle improvement, hyaluronic acid production promotion, collagen synthesis promotion, elasticity enhancement, and anti-aging, but is not limited thereto.
- improvement refers to any action that reduces at least the severity of parameters related to alleviation or treatment of conditions, for example, skin moisturizing, wrinkle improvement, hyaluronic acid production promotion, collagen synthesis promotion, elasticity enhancement, It may include any one or more of anti-aging.
- the present inventors confirmed that the fermented product of Saccharomyces cerevisiae KCTC 14268BP has excellent skin improvement effect compared to the fermented product of the general yeast Saccharomyces cerevisiae KCTC 7296. More specifically, the present inventors confirmed that the fermented product of Saccharomyces cerevisiae KCTC 14268BP has excellent effects of promoting collagen synthesis and hyaluronic acid synthesis.
- Saccharomyces cerevisiae-derived Saccharomyces cerevisiae KCTC 14268BP, its culture, or its fermented product is compared to normal yeast, its culture, or its fermented product, skin moisturizing, wrinkle improvement, elasticity enhancement, hyaluronic acid production promotion , it was confirmed that the skin improvement effects such as promoting collagen synthesis and preventing aging were confirmed.
- skin moisturizing refers to any action that supplies moisture to the skin or blocks the evaporation of moisture to maintain the skin's flexibility and induces uniform exfoliation of dead skin cells to maintain a smooth surface. It means that the skin is not hydrated enough. Specifically, the skin moisturizing may be due to the promotion of hyaluronic acid production, but is not limited thereto.
- glycosaminoglycans is a type of glycosaminoglycans and refers to a chain-shaped polymeric polysaccharide material in which glucuronic acid and N-acetylglucosamine residues are repeatedly linked.
- wrinkle can be largely divided into facial wrinkles caused by the facial muscles used for making facial expressions and fine wrinkles caused by general or local skin deterioration.
- wrinkles may be caused by genes, a decrease in collagen and elastic fibers present in the dermis of the skin, an external environment, and the like.
- wrinkles may be used in the sense of including both facial wrinkles and fine lines, but is not limited thereto.
- aging refers to a phenomenon in which biological structures and functions decline with the passage of time
- anti-aging of the present invention is not limited to the extent to which aging is improved, such as preventing, suppressing, or delaying aging. Wrinkle improvement and anti-aging in the present invention may be due to collagen synthesis promotion, but is not limited thereto.
- the cosmetic composition of the present invention is a solution, external ointment, cream, foam, nourishing lotion, soft lotion, perfume, pack, soft water, emulsion, makeup base, essence, soap, liquid detergent, bath agent, sunscreen cream, sun oil, suspension , emulsion, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch and spray, but may be a formulation selected from the group consisting of, but not limited to does not
- the cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers to be formulated in general skin cosmetics, and conventional ingredients include, for example, oil, water, surfactant, humectant, lower alcohol, thickener, A chelating agent, a colorant, a preservative, a fragrance, etc. may be appropriately blended, but the present invention is not limited thereto.
- the cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation of the cosmetic composition.
- the cosmetic formulation of the present invention is an ointment, paste, cream, or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, oxide as a carrier component Zinc or the like may be used, but is not limited thereto. These may be used alone or in combination of two or more.
- a solvent, solubilizer, or emulsifier may be used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butyl glycol oil, and the like can be used, and in particular, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, fatty acid ester of polyethylene glycol or sorbitan may be used, but is not limited thereto. These may be used alone or two or more may be used.
- the formulation of the present invention is a suspension
- a liquid diluent such as water, ethanol or propylene glycol
- a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters
- Crystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used, but is not limited thereto. These may be used alone or in combination of two or more.
- the formulation of the present invention is a soap
- alkali metal salts of fatty acids fatty acid hemiester salts, fatty acid protein hydrolyzates, isethionate, lanolin derivatives, aliphatic alcohols, vegetable oils, glycerol, sugar, etc.
- the present invention is not limited thereto. These may be used alone or in combination of two or more.
- lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder or a mixture thereof may be used as a carrier component, and in particular, in the case of a spray, additional chloro propellants such as fluorohydrocarbons, propane/butane or dimethyl ether.
- ingredients described in the present invention may be included in the composition of the present invention, preferably within a range that does not exceed the maximum use value stipulated in the regulations on cosmetic safety standards and the like and in China's 'cosmetic safety and technical norms'.
- Another aspect of the present invention is a Saccharomyces cerevisiae deposited with accession number KCTC 14268BP, a culture of the strain, and a quasi-drug composition for skin improvement comprising any one or more of a fermented product of the strain provides
- Saccharomyces cerevisiae, culture, ferment, and skin improvement are as described above.
- the term "quasi-drug” refers to body cleanser, disinfectant cleaner, cleaner, kitchen cleaner, cleaning agent, toothpaste, mouthwash, wet tissue, detergent, soap, hand wash, hair cleaner, hair softener, humidifier filler, mask, ointment, and filter It may be selected from the group consisting of fillers, but is not limited thereto.
- the quasi-drug composition of the present invention may further include a pharmaceutically acceptable carrier, excipient or diluent if necessary in addition to the above components.
- a pharmaceutically acceptable carrier, excipient or diluent is not limited as long as it does not impair the effects of the present invention, and includes, for example, fillers, extenders, binders, wetting agents, disintegrants, surfactants, lubricants, sweeteners, fragrances, preservatives, etc. may include
- Representative examples of the pharmaceutically acceptable carrier, excipient or diluent of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, maltitol, starch, gelatin, glycerin, acacia gum, alginate, calcium phosphate, calcium Carbonate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, propylene glycol, polyethylene glycol, vegetable oil , injectable esters, Witepsol, Macrogol, Tween 61, cacao butter, laurage, and the like.
- the strain of the present invention when used as a quasi-drug, it may further contain at least one active ingredient exhibiting the same or similar function.
- it may include known skin beneficial bacteria promotion, skin harmful bacteria inhibition, skin soothing, skin inflammation improvement, skin whitening, skin regeneration, wound healing, skin moisturizing, anti-aging, and elasticity enhancing ingredients.
- an additional anti-wrinkle, skin moisturizing, anti-aging, and elasticity enhancing component is included, the anti-wrinkle, skin moisturizing, anti-aging, and elasticity enhancing effect of the composition of the present invention may be further increased.
- skin safety according to combined use, ease of formulation, and stability of active ingredients can be considered.
- the quasi-drug composition of the present invention is known in the art as an anti-aging component known in the art, retinoic acid, TGF, animal placenta-derived protein, betulinic acid and chlorella extract;
- anti-inflammatory ingredients known in the art, non-steroidal flufenamic acid, ibuprofen, benzidamine, indomethacin, prednisolone, dexamethasone, allantoin, azene, hydrocortisone; and one or two or more components selected from the group consisting of derivatives thereof and various plant extracts. Additional components may be included in an amount of 0.0001% to 10% by weight based on the total weight of the composition, and the content range may be adjusted according to requirements such as skin safety, ease of formulation of the strain or fermented product of the present invention, etc. .
- the formulation method of the quasi-drug, dosage, usage method, components, etc. may be appropriately selected from conventional techniques known in the art.
- Another aspect of the present invention is Saccharomyces cerevisiae deposited with accession number KCTC 14268BP, a culture of the strain, and a food composition for skin improvement comprising any one or more of the fermented product of the strain provides
- Saccharomyces cerevisiae, culture, ferment, and skin improvement are as described above.
- the term "food” refers to meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, various soups, beverages, tea, drinks, alcoholic beverages, There are vitamin complexes, health functional foods, health foods, and the like, and includes all foods in the ordinary sense.
- the functional food is the same term as food for special health use (FoSHU), and in addition to supplying nutrients, it is processed to efficiently exhibit bioregulatory functions and has high medical effects.
- function (sex) means to obtain a useful effect for health purposes such as regulating nutrients or physiological action with respect to the structure and function of the human body.
- the food of the present invention can be prepared by a method commonly used in the art, and during the manufacture, it can be prepared by adding raw materials and components commonly added in the art.
- the formulation of the food may be prepared without limitation as long as it is a formulation recognized as a food.
- composition for food of the present invention can be prepared in various forms, and unlike general drugs, it has the advantage that there are no side effects that may occur during long-term administration of the drug using food as a raw material, and it is excellent in portability, and the present invention Foods of can be consumed as a supplement to enhance the skin improvement effect.
- the health food means a food having an active health maintenance or promotion effect compared to general food
- the health supplement food means a food for the purpose of health supplementation.
- the terms health functional food, health food, and dietary supplement are used interchangeably.
- the health functional food is Saccharomyces cerevisiae deposited with accession number KCTC 14268BP, the culture of the strain, and any one or more of the fermented product of the strain beverage, tea, spices, gum , Confectionery, etc., or manufactured as encapsulation, powder, suspension, etc., which means that it has a specific effect on health when ingested. It has the advantage that there are no side effects that may occur during long-term use.
- the food composition of this invention can be ingested on a daily basis, a high skin improvement effect can be anticipated, and it is very useful.
- composition may further include a physiologically acceptable carrier, the type of carrier is not particularly limited, and any carrier commonly used in the art may be used.
- the composition may include additional ingredients that are commonly used in food compositions to improve odor, taste, vision, and the like.
- vitamins A, C, D, E, B1, B2, B6, B12, niacin, biotin, folate, pantothenic acid, and the like may be included.
- it may include minerals such as zinc (Zn), iron (Fe), calcium (Ca), chromium (Cr), magnesium (Mg), manganese (Mn), copper (Cu), and chromium (Cr).
- it may include amino acids such as lysine, tryptophan, cysteine, and valine.
- the composition includes a preservative (potassium sorbate, sodium benzoate, salicylic acid, sodium dehydroacetate, etc.), a disinfectant (bleaching powder and high bleaching powder, sodium hypochlorite, etc.), an antioxidant (butylhydroxyanisole (BHA), butylhydroxy Toluene (BHT), etc.), coloring agents (tar pigments, etc.), coloring agents (sodium nitrite, sodium nitrite, etc.), bleach (sodium sulfite), seasonings (MSG sodium glutamate, etc.), sweeteners (dulcin, cyclamate, saccharin, Sodium, etc.), flavorings (vanillin, lactones, etc.), swelling agents (alum, D-potassium hydrogen tartrate, etc.), strengthening agents, emulsifiers, thickeners (flavors), film agents, gum base agents, foam inhibitors, solvents, food additives such as improving agents (food additives).
- the additive may be selected according to the
- Saccharomyces cerevisiae deposited with the accession number KCTC 14268BP, the culture of the strain, and any one or more of the fermented product of the strain can be added as it is or used with other foods or food ingredients, It may be appropriately used according to a conventional method.
- the mixed amount of the active ingredient may be suitably determined according to the purpose of its use (prevention, health or therapeutic treatment).
- the food composition of the present invention may be added in an amount of 50 parts by weight or less, specifically 20 parts by weight or less with respect to the food or beverage, but is not limited thereto.
- the food composition of the present invention may be used as a health drink composition, and in this case, it may contain various flavoring agents or natural carbohydrates as an additional component like a conventional drink.
- the above-mentioned natural carbohydrates include monosaccharides such as glucose and fructose; disaccharides such as maltose and sucrose; polysaccharides such as dextrin and cyclodextrin; It may be a sugar alcohol such as xylitol, sorbitol, or erythritol.
- Sweeteners include natural sweeteners such as taumatine, stevia extract; A synthetic sweetener such as saccharin or aspartame may be used.
- the proportion of the natural carbohydrate is generally about 0.01 to 0.04 g, specifically, about 0.02 to 0.03 g per 100 mL of the composition of the present invention.
- the health beverage composition includes various nutrients, vitamins, electrolytes, flavoring agents, colorants, pectic acid, pectic acid salts, alginic acid, alginic acid salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, It may contain alcohol, a carbonation agent, or the like. In addition, it may contain the pulp for the production of natural fruit juice, fruit juice beverage, or vegetable beverage. These components may be used independently or in combination. Although the proportion of these additives is not critical, it is generally selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the composition of the present invention.
- the food composition of the present invention may include various weight % if it can exhibit a skin improvement effect, specifically, Saccharomyces cerevisiae deposited with accession number KCTC 14268BP ( Saccharomyces cerevisiae ), the culture of the strain, and the Any one or more of the fermented product of the strain may be included in an amount of 0.00001 to 100% by weight relative to the total weight of the food composition.
- Saccharomyces cerevisiae deposited with accession number KCTC 14268BP, the culture of the strain, and the fermented product of the strain may be included in quasi-drugs, food, and/or cosmetic compositions as described above, but may be included in pharmaceutical compositions It may also be included in the composition.
- Saccharomyces cerevisiae deposited with accession number KCTC 14268BP Saccharomyces cerevisiae Any one or more of a strain, a culture of the strain, and a fermented product of the strain; Or it provides a skin improvement method comprising the step of administering to the subject a food composition comprising the same.
- the administration is oral administration, and may be ingestion and/or inhalation, and the Saccharomyces cerevisiae, culture, ferment, and skin improvement are as described above.
- the term “individual” refers to all animals including mammals, including mice, livestock, and humans, but is not limited thereto.
- Saccharomyces cerevisiae deposited with accession number KCTC 14268BP Saccharomyces cerevisiae Any one or more of a strain, a culture of the strain, and a fermented product of the strain; a cosmetic composition comprising the same; And/or it provides a skin improvement method comprising the step of applying (apply) the quasi-drug composition comprising the same to the skin of an individual.
- Saccharomyces cerevisiae, culture, ferment, and skin improvement are as described above.
- applying means contacting the composition of the present invention to the skin of an individual by any suitable method, and includes all actions aimed at absorbing the composition into the skin through this, but not limited
- Another aspect of the present invention is a Saccharomyces cerevisiae strain deposited with accession number KCTC 14268BP, a culture of the strain, and a fermented product of the strain It provides a skin improvement use of any one or more .
- Saccharomyces cerevisiae, culture, ferment, and skin improvement are as described above.
- Example 1 Isolation and selection of yeast strains from cheolpisuk grain
- the 7 types of yeast (6 types of Saccharomyces cerevisiae and 1 type of Saccharomyces bouladi) secured in the present invention are shown in Table 1 below.
- strain Score (average score of 10 people) One 2.9 2 3.5 3 3.1 4 2.8 5 1.5 6 3.0 7 2.6
- the yeast Saccharomyces cerevisiae #5-31 strain obtained in the present invention was deposited with the Korea Research Institute of Bioscience and Biotechnology, a trustee institution under the Budapest Treaty, on August 10, 2020, and was given an accession number KCTC 14268BP.
- the yeast ( Saccharomyces cerevisiae KCTC 14268BP) strain was inoculated in YPD medium, cultured with shaking at 30° C. for 4 days, and then the cells were separated by centrifugation. After the cells were suspended in purified water, the cells were crushed by ultrasonic treatment, and finally, a yeast fermented product of cheolpiseokgok was prepared. Specific conditions and configurations are shown in Table 4 below.
- the yeast fermented product of the present invention exhibits excellent effects in improving skin wrinkles, enhancing elasticity, and preventing aging.
- Hyaluronic acid synthesis rate was derived by measuring hyaluronic acid using R&D systems' Quantikine ELISA Hyaluronan. The skin moisturizing ability of the sample was expressed as a quantified, hyaluronic acid synthesis increase rate (%) compared to the control (DMEM treatment containing 0% serum).
- Hyaluronic acid synthesis increase rate (%) (hyaluronic acid synthesis rate of sample - hyaluronic acid synthesis rate of negative control group) / hyaluronic acid synthesis rate of negative control group
- the fermented product of the fermented yeast (KCTC 14268BP) of the present invention exhibits an excellent effect in moisturizing the skin.
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Abstract
Description
NO | Microorganism |
1 | Saccharomyces cerevisiae #1-7 |
2 | Saccharomyces cerevisiae #2-13 |
3 | Saccharomyces cerevisiae #3-5 |
4 | Saccharomyces cerevisiae #4-17 |
5 | Saccharomyces cerevisiae #5-31 |
6 | Saccharomyces boulardii #6-21 |
7 | Saccharomyces cerevisiae #7-3 |
점수 | 지표 |
1 | 향취가 느껴지지 않음. |
2 | 특유한 향취가 있는지 없는지 분간이 안됨 |
3 | 특유한 향취가 있음 |
4 | 특유한 향취가 있으며, 향취가 호감이 가지 않음 |
5 | 특유한 향취가 있으며, 향취가 매우 불쾌함 |
균주 | 점수 (10명의 평균 점수) |
1 | 2.9 |
2 | 3.5 |
3 | 3.1 |
4 | 2.8 |
5 | 1.5 |
6 | 3.0 |
7 | 2.6 |
Strain | Saccharomyces cerevisiae #5-31 strain (KCTC 14268BP) |
배양조건 | YPD media, 4day, 30 180 rpm |
Sonication | Amplitude 30, Process time 40 min, Pulse-ON time 1 S, Plus-OFF time 4 S |
철피석곡 효모 배양 추출물의 농도 | 5% |
시료 | 콜라겐 합성 증가율 |
일반세포(음성 대조군) | 0 |
일반세포 + TGF-β(양성 대조군, 10ppb) | 15.2 |
일반세포 + 철피석곡 효모(KCTC 14268BP) 발효물 (0.01%) | 38.3 |
일반세포 + 일반 효모 (KCTC 7296) 발효물 (0.01%) | 6.0 |
시료 | 히알루론산 합성 증가율 |
일반세포(음성 대조군) | 0 |
일반세포 + Retinoic acid (양성 대조군, 1ppm) | 13.8 |
일반세포 + 철피석곡 효모(KCTC 14268BP) 발효물 (0.01%) | 9.8 |
일반세포 + 일반 효모 (KCTC 7296) 발효물 (0.01%) | 9.3 |
Claims (9)
- 기탁번호 KCTC 14268BP로 기탁된 사카로미세스 세레비시에(Saccharomyces cerevisiae) 균주.
- 제1항에 있어서, 상기 사카로미세스 세레비시에(Saccharomyces cerevisiae)는 철피석곡(Dendrobium candidum) 유래인, 균주.
- 제1항에 있어서, 상기 사카로미세스 세레비시에(Saccharomyces cerevisiae)는 철피석곡(Dendrobium candidum) 꽃 유래인, 균주.
- 제1항의 균주, 상기 균주의 배양물, 및 상기 균주의 발효물 중 어느 하나 이상을 포함하는 피부 개선용 화장료 조성물.
- 제4항에 있어서, 상기 피부 개선은 피부 보습, 주름 개선, 탄력 증진, 히알루론산 생성 촉진, 콜라겐 합성 촉진, 및 노화 방지로 이루어진 군에서 선택된 어느 하나 이상인 것인, 화장료 조성물.
- 제1항의 균주, 상기 균주의 배양물, 및 상기 균주의 발효물 중 어느 하나 이상을 포함하는 피부 개선용 의약외품 조성물.
- 제6항에 있어서, 상기 피부 개선은 피부 보습, 주름 개선, 탄력 증진, 히알루론산 생성 촉진, 콜라겐 합성 촉진, 및 노화 방지로 이루어진 군에서 선택된 어느 하나 이상인, 의약외품 조성물.
- 제1항의 균주, 상기 균주의 배양물, 및 상기 균주의 발효물 중 어느 하나 이상을 포함하는 피부 개선용 식품 조성물.
- 제8항에 있어서, 상기 피부 개선은 피부 보습, 주름 개선, 탄력 증진, 히알루론산 생성 촉진, 콜라겐 합성 촉진, 및 노화 방지로 이루어진 군에서 선택된 어느 하나 이상인, 식품 조성물.
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CN202180053891.5A CN116096351A (zh) | 2020-12-23 | 2021-12-23 | 新型酿酒酵母菌株及其用途 |
US18/258,841 US20240041754A1 (en) | 2020-12-23 | 2021-12-23 | Novel saccharomyces cerevisiae strain and use thereof |
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- 2021-12-22 KR KR1020210185198A patent/KR20220091409A/ko not_active Application Discontinuation
- 2021-12-23 US US18/258,841 patent/US20240041754A1/en active Pending
- 2021-12-23 CN CN202180053891.5A patent/CN116096351A/zh active Pending
- 2021-12-23 JP JP2023539052A patent/JP2024500509A/ja active Pending
- 2021-12-23 WO PCT/KR2021/019700 patent/WO2022139502A1/ko active Application Filing
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CN115337226A (zh) * | 2022-08-22 | 2022-11-15 | 广州雅纯化妆品制造有限公司 | 一种美白组合物、化妆品及其制备方法 |
CN115337226B (zh) * | 2022-08-22 | 2024-02-23 | 广州雅纯化妆品制造有限公司 | 一种美白组合物、化妆品及其制备方法 |
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KR20220091409A (ko) | 2022-06-30 |
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