WO2022126948A1 - Composition de médecine chinoise traditionnelle et son utilisation dans la préparation d'un médicament pour le traitement d'une hernie indirecte - Google Patents

Composition de médecine chinoise traditionnelle et son utilisation dans la préparation d'un médicament pour le traitement d'une hernie indirecte Download PDF

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Publication number
WO2022126948A1
WO2022126948A1 PCT/CN2021/088036 CN2021088036W WO2022126948A1 WO 2022126948 A1 WO2022126948 A1 WO 2022126948A1 CN 2021088036 W CN2021088036 W CN 2021088036W WO 2022126948 A1 WO2022126948 A1 WO 2022126948A1
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WIPO (PCT)
Prior art keywords
preparation
traditional chinese
chinese medicine
borneol
parts
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PCT/CN2021/088036
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English (en)
Chinese (zh)
Inventor
朱一强
李平
王海洋
王兴旺
曾青钦
Original Assignee
海南蛛王生物科技有限公司
朱一强
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Publication of WO2022126948A1 publication Critical patent/WO2022126948A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and its application in preparing a medicine for treating fox hernia.
  • Fox hernia the name of the disease in traditional Chinese medicine. It is caused by the loss of liver qi, or when children and elderly people have weak qi, or when the intra-abdominal pressure increases, the intestines and other abdominal organs slide into the scrotum.
  • a hernia disease characterized by a lump in the groin, sometimes big or small, full of pain, such as fox's impermanence.
  • Golden Chamber Synopsis records: "The hernia of the yin fox is small and large, and it is always up and down, and the spider is scattered.” This clearly points out the clinical characteristics and the main treatment of the hernia of the yin fox.
  • fox hernia is diagnosed early, the condition is mild, and the prognosis is generally good. If the disease is severe and the righteousness is weak, some patients may also be accompanied by complications such as intestinal obstruction, abdominal pain, and shock.
  • the spider powder composed of spiders and cinnamon sticks recorded in the Synopsis of the Golden Chamber is the most famous traditional Chinese medicine prescription. But in modern times, there are few researches on traditional Chinese medicine prescriptions for the treatment of fox hernia.
  • the technical problem to be solved by the present invention is to provide a traditional Chinese medicine composition and its application in the preparation of a medicament for treating fox hernia, in order to more effectively treat fox hernia.
  • the traditional Chinese medicine composition provided by the present invention, its raw materials include spider, cinnamon stick, Bupleurum, astragalus, cohosh, ginger and borneol.
  • the traditional Chinese medicine composition is made from the following raw materials by mass: 4-6 parts of spider, 80-120 parts of cinnamon stick, 80-120 parts of Bupleurum, 50-70 parts of Astragalus, 25-35 parts of Cimicifuga servings, 80-120 servings of ginger, and 4-6 servings of borneol.
  • it is made from the following raw materials by mass: 5 parts of spiders, 100 parts of cinnamon sticks, 100 parts of Bupleurum, 60 parts of astragalus, 30 parts of cohosh, 100 parts of ginger, and 5 parts of borneol.
  • the preparation method of described Chinese medicine composition comprises:
  • the cassia twig and ginger are extracted by steam distillation to obtain volatile oil;
  • the borneol is dissolved in an aqueous ethanol solution to obtain a borneol solution;
  • the traditional Chinese medicine composition is prepared by adjusting the volume fraction of ethanol in the mixture to 28-32% with water and ethanol with a volume fraction of 85% to 95%.
  • the preparation method of the volatile oil comprises the following steps: after soaking the cassia twig and ginger in water, steam distillation for 1 hour; and extracting the combined extracts twice to obtain the volatile oil.
  • the infiltration refers to the degree of moisturizing the cinnamon sticks and ascending and descending, but no water flow.
  • the volume fraction of ethanol in the ethanol aqueous solution is 60%.
  • the mass-volume ratio of the sum of the mass of spider, Bupleurum, Astragalus, and Cimicifuga to the ethanol aqueous solution is 100 g: 600 mL.
  • the extraction is reflux extraction, and the time for each extraction is 1.5 hours. Extract in two steps, combine the extracts, and concentrate to a relative density of 1.15.
  • the volume fraction of ethanol in the ethanol aqueous solution for preparing the borneol solution in the present invention is 90%.
  • the volatile oil, the extract, and the borneol solution are mixed, and the volume ratio of the mixing is 10:420:20.
  • the volume fraction of ethanol is adjusted to 30% with water and a 90% ethanol solution to prepare a traditional Chinese medicine composition.
  • the present invention also provides a medicine for treating fox hernia, which comprises the composition of the present invention.
  • the medicine for treating fox hernia of the present invention is in the form of a spray.
  • the present invention also provides a method for treating fox hernia, which is to administer the medicine of the present invention.
  • the raw materials of the composition provided by the present invention include spider, cinnamon stick, Bupleurum, astragalus, cohosh, ginger and borneol. It uses spider as the monarch medicine, with Chinese medicinal materials such as Guizhi and Bupleurum as the minister medicine and auxiliary medicine, which plays a good role in the treatment of fox hernia, and its effect is significantly better than the traditional Jinfang spider powder.
  • the invention provides a traditional Chinese medicine composition and its application in the preparation of a medicine for treating fox hernia, and those skilled in the art can learn from the content of this article and appropriately improve the process parameters to achieve. It should be particularly pointed out that all similar substitutions and modifications are obvious to those skilled in the art, and they are deemed to be included in the present invention.
  • the method and application of the present invention have been described through the preferred embodiments, and it is obvious that relevant persons can make changes or appropriate changes and combinations of the methods and applications herein without departing from the content, spirit and scope of the present invention, so as to realize and apply the present invention. Invention technology.
  • test materials used in the present invention are all common commercial products and can be purchased in the market.
  • the spider is the whole worm of Jingzhao tassular spider artificially cultivated by the applicant in the Wuzhishan spider breeding base.
  • Bitter cold, poisonous. Enters the Liver Meridian of Jueyin of Foot. Dispel wind, reduce swelling, and detoxify. Treatment of partial fall of fox hernia, crooked mouth after stroke, slow convulsion in children, choked mouth, malnutrition accumulation;
  • Bupleurum is the dried root of Bupleurum chinense DC. or Bupleurum scorzonerifolium Willd. The taste is bitter, slightly cold. Return to the liver and gallbladder meridians. Reconcile the inside and outside, soothe the liver and raise the yang. For colds and fever, cold and heat exchanges, chest and flank pain, irregular menstruation, prolapse of the genitals, prolapse of the anus.
  • Cinnamomum cassia twig is the dry twig of the Lauraceae plant Cinnamomum cassia Presl; nature and flavor: spicy, sweet, warm.
  • Astragalus is the dried root of the legume Astragalus membranaceus (Fisch.) Bge.var. mongolicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. Sweet, warm. Return to the lung and spleen meridians. Invigorating Qi and solidifying the surface, diuretic support toxins, expelling pus, astringing sores and producing muscles.
  • Cimicifuga is the dried rhizome of the Ranunculaceae plant Cimicifuga heracleifolia Kom., Cimicifuga dahurica (Turcz.) Maxim. or Cimicifuga foetida L.. Purgit in nature, slightly sweet, slightly cold. Returns the lung, spleen, stomach, and large intestine meridians. It expresses rash, clears heat and detoxifies, and lifts yang. For wind-heat headache, toothache, mouth sore, sore throat, measles opacity, yang poisoning spots; prolapse of the anus, uterine prolapse.
  • Ginger is the fresh rhizome of the ginger plant Zingiber officinale Rosc. Returns the lung, spleen and stomach meridians. Relieves the exterior and dispels cold, warms the middle to stop vomiting, resolves phlegm and stops cough. For wind-cold cold, stomach-cold vomiting, cough with cold phlegm.
  • Borneol also known as synthetic borneol, plum slices, moxa powder, and knot slices, is acrid, bitter and slightly cold in nature. Return to the heart, spleen and lung meridians. Refreshing, clearing heat and relieving pain. For fever dizziness, convulsions, stroke phlegm Jue, Qi stagnation violent Jue, middle aversion coma, red eyes, mouth sores, sore throat, ear canal pus.
  • the borneol was dissolved in 20 mL of 90% ethanol to obtain a borneol solution.
  • the borneol was dissolved in 20 mL of 90% ethanol to obtain a borneol solution.
  • Spider dried powder 5g Bupleurum 100g, Astragalus 60g, Cimicifuga 30g, Ginger 100g, Borneol 5g.
  • the borneol was dissolved in 20 mL of 90% ethanol to obtain a borneol solution.
  • the borneol was dissolved in 20 mL of 90% ethanol to obtain a borneol solution.
  • the borneol was dissolved in 20 mL of 90% ethanol to obtain a borneol solution.
  • Example 1 and Comparative Examples 1 to 5 were prepared in a hospital of traditional Chinese medicine in Hainan province, and clinical trials were carried out in the professional clinic of Li nationality medicine. After more than 3 years of clinical verification, this technical method has a significant effect on the treatment of fox hernia.
  • Example 1 13 3 2 2 90 Control 1 (missing spiders) 4 2 5 9 55 Control group 2 (lack of cinnamon sticks) 6 5 1 8 60 Control 3 (lack of Bupleurum) 8 3 4 5 75 Control 4 (lack of Astragalus) 9 2 5 4 80 Control group 5 (spider powder) 6 7 2 5 75 Control group 6 (untreated) 0 0 0 20 0
  • the preparation of the present invention has a significant curative effect on the treatment of fox hernia, and through the scientific compatibility of medicinal materials, its curative effect is stronger than that of the traditional Jinfang spider powder for treating fox hernia, and is also better than other control groups lacking a certain drug.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une composition de médecine chinoise traditionnelle pour le traitement d'une hernie indirecte, ainsi que son procédé de préparation et son utilisation. Les matières premières de la composition sont des araignées, Cinnamomi ramulus, Bupleuri radix, Astragali radix, Cimicifugae rhizoma, Zingiberis rhizoma recens et Borneolum syntheticum.
PCT/CN2021/088036 2020-12-14 2021-04-19 Composition de médecine chinoise traditionnelle et son utilisation dans la préparation d'un médicament pour le traitement d'une hernie indirecte WO2022126948A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202011472303.5A CN112535722B (zh) 2020-12-14 2020-12-14 中药组合物及其在制备治疗狐疝的药物中的应用
CN202011472303.5 2020-12-14

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WO2022126948A1 true WO2022126948A1 (fr) 2022-06-23

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107823400A (zh) * 2017-11-23 2018-03-23 广东三蓝药业股份有限公司 一种益气升陷丸及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
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US5240708A (en) * 1991-07-03 1993-08-31 Plummer Donald E Composition and method for discouraging spiders, insects or the like
CN1142389A (zh) * 1996-07-09 1997-02-12 刘金育 一种治疗疝气的中药组合物
CN1899374A (zh) * 2006-07-07 2007-01-24 唐麟 一种治疗疝气的苗药散剂
WO2008077277A1 (fr) * 2006-12-25 2008-07-03 Graduate School At Shenzhen, Tsinghua University Procédé de préparation d'un lyophilisat d'araignée et son utilisation dans des médicaments ou des alicaments
CN108815432A (zh) * 2018-08-16 2018-11-16 陈怀银 一种治疗疝气的药物及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107823400A (zh) * 2017-11-23 2018-03-23 广东三蓝药业股份有限公司 一种益气升陷丸及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FU GUOGUANG: "A Case of Pediatric Hernia Treated by Supplemented Zhi Zhu San", FORUM ON TRADITIONAL CHINESE MEDICINE, no. 2, 1 May 1986 (1986-05-01), pages 13 - 13, XP055944290 *
YU XIBIN: "Treatment of Pediatric Indirect Inguinal Hernia by "Internal Lifting and External Support"", JIANGXI JOURNAL OF TRADITIONAL CHINESE MEDICINE, no. 6, 30 June 1989 (1989-06-30), pages 38 - 38, XP055944292 *

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CN112535722A (zh) 2021-03-23

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