WO2022099656A1 - 一种皮肤清洁剂组合物及其应用 - Google Patents
一种皮肤清洁剂组合物及其应用 Download PDFInfo
- Publication number
- WO2022099656A1 WO2022099656A1 PCT/CN2020/128835 CN2020128835W WO2022099656A1 WO 2022099656 A1 WO2022099656 A1 WO 2022099656A1 CN 2020128835 W CN2020128835 W CN 2020128835W WO 2022099656 A1 WO2022099656 A1 WO 2022099656A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fatty acid
- sodium
- cleansing composition
- skin cleansing
- skin
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- -1 fatty acid salt Chemical class 0.000 claims abstract description 40
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 17
- 239000000194 fatty acid Substances 0.000 claims abstract description 17
- 229930195729 fatty acid Natural products 0.000 claims abstract description 17
- 239000003945 anionic surfactant Substances 0.000 claims abstract description 10
- 239000006260 foam Substances 0.000 claims abstract description 10
- 239000002562 thickening agent Substances 0.000 claims abstract description 8
- 239000002888 zwitterionic surfactant Substances 0.000 claims abstract description 7
- 239000003755 preservative agent Substances 0.000 claims abstract description 6
- 230000002335 preservative effect Effects 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
- 238000004140 cleaning Methods 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 229940117986 sulfobetaine Drugs 0.000 claims description 8
- 239000003002 pH adjusting agent Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 230000003020 moisturizing effect Effects 0.000 claims description 6
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 5
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 claims description 4
- IZWSFJTYBVKZNK-UHFFFAOYSA-N lauryl sulfobetaine Chemical group CCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O IZWSFJTYBVKZNK-UHFFFAOYSA-N 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- MQFYRUGXOJAUQK-UHFFFAOYSA-N 2-[2-[2-(2-octadecanoyloxyethoxy)ethoxy]ethoxy]ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCOCCOCCOC(=O)CCCCCCCCCCCCCCCCC MQFYRUGXOJAUQK-UHFFFAOYSA-N 0.000 claims description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims description 3
- 239000003906 humectant Substances 0.000 claims description 3
- 229940070765 laurate Drugs 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 229940105132 myristate Drugs 0.000 claims description 3
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 229940049964 oleate Drugs 0.000 claims description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 3
- 229960005323 phenoxyethanol Drugs 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- 239000000375 suspending agent Substances 0.000 claims description 3
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 claims description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 2
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 claims description 2
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 2
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 2
- 229920002101 Chitin Polymers 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- 241001506047 Tremella Species 0.000 claims description 2
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 235000019270 ammonium chloride Nutrition 0.000 claims description 2
- 239000002280 amphoteric surfactant Substances 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- 229940031728 cocamidopropylamine oxide Drugs 0.000 claims description 2
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 2
- 235000019387 fatty acid methyl ester Nutrition 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229940051250 hexylene glycol Drugs 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims description 2
- 229940044591 methyl glucose dioleate Drugs 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical group CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- BOUCRWJEKAGKKG-UHFFFAOYSA-N n-[3-(diethylaminomethyl)-4-hydroxyphenyl]acetamide Chemical compound CCN(CC)CC1=CC(NC(C)=O)=CC=C1O BOUCRWJEKAGKKG-UHFFFAOYSA-N 0.000 claims description 2
- 235000021317 phosphate Nutrition 0.000 claims description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 229960004063 propylene glycol Drugs 0.000 claims description 2
- 239000000344 soap Substances 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 2
- 229940057950 sodium laureth sulfate Drugs 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 2
- 229960001763 zinc sulfate Drugs 0.000 claims description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 229940015975 1,2-hexanediol Drugs 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 1
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 claims 1
- 108010077895 Sarcosine Proteins 0.000 claims 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 229920000223 polyglycerol Polymers 0.000 claims 1
- 229940048098 sodium sarcosinate Drugs 0.000 claims 1
- TYLSDQJYPYQCRK-UHFFFAOYSA-N sulfo 4-amino-4-oxobutanoate Chemical compound NC(=O)CCC(=O)OS(O)(=O)=O TYLSDQJYPYQCRK-UHFFFAOYSA-N 0.000 claims 1
- 238000005187 foaming Methods 0.000 abstract description 7
- 239000004909 Moisturizer Substances 0.000 abstract 1
- 230000001333 moisturizer Effects 0.000 abstract 1
- 239000003599 detergent Substances 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 229920000881 Modified starch Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- DFQDHMNSUGBBCW-UHFFFAOYSA-N 1,4-diamino-1,4-dioxobutane-2-sulfonic acid Chemical compound NC(=O)CC(C(N)=O)S(O)(=O)=O DFQDHMNSUGBBCW-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- UITSPQLTFPTHJZ-XTLGRWLVSA-N 2-[[(2r,6r)-3,4,5-tris(2-hydroxyethoxy)-6-methoxyoxan-2-yl]methoxy]ethanol Chemical class CO[C@@H]1O[C@H](COCCO)C(OCCO)C(OCCO)C1OCCO UITSPQLTFPTHJZ-XTLGRWLVSA-N 0.000 description 1
- CYMRPDYINXWJFU-UHFFFAOYSA-N 2-carbamoylbenzoic acid Chemical compound NC(=O)C1=CC=CC=C1C(O)=O CYMRPDYINXWJFU-UHFFFAOYSA-N 0.000 description 1
- BCFOOQRXUXKJCL-UHFFFAOYSA-N 4-amino-4-oxo-2-sulfobutanoic acid Chemical class NC(=O)CC(C(O)=O)S(O)(=O)=O BCFOOQRXUXKJCL-UHFFFAOYSA-N 0.000 description 1
- OCPHADBLNGJUTI-UHFFFAOYSA-N CCCCCCCCCCCCCCCC[N+]([O-])(O)O Chemical compound CCCCCCCCCCCCCCCC[N+]([O-])(O)O OCPHADBLNGJUTI-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 229940114077 acrylic acid Drugs 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical class OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 238000004851 dishwashing Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- RBNPOMFGQQGHHO-UHFFFAOYSA-N glyceric acid Chemical compound OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 229920001451 polypropylene glycol Chemical class 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
Definitions
- the present invention relates to the field of biotechnology, in particular to a skin cleanser composition and its application field.
- Surfactant is a commonly used auxiliary substance. When the amount of addition is small, it can greatly reduce the surface tension of the solvent and change the interface state of the system, resulting in a series of properties such as wetting, emulsification, and foaming.
- Anionic surfactants a commonly used surface active compound, are used in various aspects of the cosmetic field, in addition to detergents and cleaning products.
- conventional anionic surfactants in cosmetics are alkyl ether sulfates. These salts are characterized by strong foaming ability, high cleaning power, low sensitivity to hardness and grease, and are widely used in the production of cosmetics, such as shampoos, shower gels, and dishwashing detergents.
- the object of the present invention is to provide a detergent composition in order to meet the different requirements of users for skin cleaning products, and the detergent has the following properties besides being used for cleaning: good foaming ability, generated foam It is dense and thick; it has good skin compatibility; the product is stable and easy to store.
- a detergent composition includes the following components, component a, component b, component c, wherein component a is a fatty acid salt, and component b is an anionic surfactant , component c is a zwitterionic surfactant, and also includes a pH adjuster, a moisturizing agent, a thickener, a preservative and water; wherein the ratio of component a fatty acid salt to the zwitterionic surfactant is based on the total weight of the composition 0.5:1-2:1.
- the structure of the fatty acid salt in the component a is generally fatty acid methyl ester sulfonate, laurate, isostearate, myristate, palmitate, arachidate, oleate, and the like. Among them, at least one selected from the group consisting of laurate, myristate, palmitate, stearate, and oleate is preferred.
- salts include alkali metal salts such as potassium salts; ammonium salts; ammonium salts derived from alkanolamines such as diethanolamine salts and triethanolamine salts; and basic amino acid salts such as arginine salts and lysine salts. Wait.
- alkali metal salts such as potassium salts
- ammonium salts such as ammonium salts derived from alkanolamines such as diethanolamine salts and triethanolamine salts
- basic amino acid salts such as arginine salts and lysine salts. Wait.
- the component b anionic surfactants are cleansing substances other than fatty acid salts that are generally used on the skin, and examples thereof include ammonium laureth sulfate, sodium laureth sulfate, and laureth sulfate. At least one of sodium lauroyl sarcosinate, sodium lauroyl oat amino acid; alkyl ether carboxylates, alkyl benzene sulfonates, alkane sulfonates, olefin sulfonates, glyceryl ether sulfonates, alpha Methyl ester sulfonate, sulfofatty acid salt, alkyl sulfate, fatty alcohol ether sulfate, glycerol ether sulfate, hydroxy mixed ether sulfate, monoalkyl sulfosuccinate, monoalkyl sulfosuccinamide acid salts, dialkyl sul
- Component C amphoteric surfactants as long as they are commonly used in skin cleansers, for example, dodecyl sulfobetaine, dodecyl ethoxy sulfobetaine, dodecane hydroxypropyl sulfobetaine, dodecyl sulfopropyl betaine, tetradecyl amidopropyl hydroxypropyl sulfobetaine, decyl hydroxypropyl sulfobetaine, tetradecyl dihydroxy Ethylamine oxide, cocamidopropylamine oxide, etc.
- dodecyl sulfobetaine dodecyl ethoxy sulfobetaine
- dodecane hydroxypropyl sulfobetaine dodecyl sulfopropyl betaine
- tetradecyl amidopropyl hydroxypropyl sulfobetaine decyl hydroxy
- the preservative is selected from methylisothiazolinone, methylchloroisothiazolinone MCI, paraben, phenoxyethanol, sodium benzoate, ethylhexylglycerol, methylparaben, 1,2- At least one of hexanediol. It is preferably at least one of phenoxyethanol and sodium benzoate.
- the combination also includes one or more of suspending agents, pH adjusting agents, humectants, thickening agents, .
- the pH adjuster is selected from one or more of citric acid and sodium citrate, sodium hydroxide, potassium hydroxide and triethanolamine, preferably at least one of citric acid and sodium citrate.
- the humectant is selected from: glycerol, butylene glycol, polyethylene glycol, propylene glycol, hexylene glycol, xylitol (Xylitol), polypropylene glycol, sorbitol, methylgluceth, chitin derivatives At least one of the substances, trehalose, Tremella polysaccharide, sodium hyaluronate, etc.
- Described thickening agent is selected from PEG-120 methyl glucose dioleate, hydroxypropyl methyl cellulose, sodium chloride, ammonium chloride, sodium sulfate, zinc sulfate, PEG-90M, PEG-14M, PEG - At least one of 150 distearate. It is preferably at least one of PEG-14M, PEG-150 distearate and sodium chloride.
- the suspending agent is selected from at least one of modified corn starch, di(hydrogenated tallow) phthalic acid amide, carbomer, xanthan gum, acrylic acid (ester) copolymer and mixtures thereof.
- Modified corn starch is preferred.
- the skin cleansing composition prepared according to the composition of the present application has certain moisturizing strength and good skin compatibility.
- the application also provides a skin cleansing composition comprising the following components by weight,
- the specific preparation method is as follows:
- the prepared cleaning products were characterized to determine the performance of the products.
- Example 2 the foamability of the product and the degree of foam density-free were investigated.
- the foaming time and the volume of foam in a certain period of time were measured by adding 1 ml of the product with the ratio 1 to 100 ml of water to characterize the stability of the foam.
- the skin compatibility of the cleansing products of the present application was evaluated by examining the humidity of the products.
- composition of the present application has a certain moisturizing strength and good skin compatibility.
- the skin cleansing composition of the present invention has high lather, rapid lather and long-lasting lather. At the same time, the shape of the cleaning composition is stable under different pH conditions, and the shape of the cleaning composition is relatively stable without obvious change at different temperatures. So it is suitable for cleansing products, hand soaps, body washes, cleaning foams, etc.
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Abstract
为了满足用户对于皮肤清洁组合物的要求，提供一种洗涤剂组合物，洗涤剂除了用于清洁之外还具有如下的性能：良好的发泡能力，所产生的泡沫绵密浓稠；具有较好的皮肤相容性；产品状态稳定，易于保存。采用的技术方案如下：一种洗涤剂组合物包括以下的组分，组分a、组分b和组分c，其中组分a为脂肪酸盐、组分b为阴离子表面活性剂、组分c为两性离子表面活性剂，此外还包括pH调节剂、保湿剂、增稠剂、防腐剂以及水；其中脂肪酸盐与两性离子表面活性剂的比例按组合物总重量的0.5：1-2：1。
Description
本发明涉及生物技术领域，特别涉及一种皮肤清洁剂组合物及其应用领域。
表面活性剂是一种常用的助剂物质，在加入量很少时，能大大降低溶剂的表面张力，改变体系的界面状态，从而产生湿润、乳化、起泡等一些列性质。
阴离子表面活性剂，是一种普遍使用的界面活性化合物，除了用于洗涤剂和清洁产品之外，还用于化妆品领域中各个方面的用途。特别是化妆品中常规阴离子表面活性剂是烷基醚硫酸盐。此类盐的特征在于发泡能力强，清洁力度高，对于硬度和油脂的敏感性低，并广泛应用于化妆品的生产，例如洗发水，沐浴露，以及餐具洗涤剂等。
对于目前的应用，除了良好的活性应用之外，用户还对阴离子表面活性剂提出了其他的要求。例如在化妆品领域，对于使用感，洗涤剂的发泡能力，以及接触感和洗涤剂与皮肤的相容性等。并且对于所制备的产品具有良好的环境效应。
发明内容
本发明的目的是为了满足用户对于皮肤清洁产品的不同要求，提供一种洗涤剂组合物，所述洗涤剂除了用于清洁之外还具有如下的性能：良好的发泡能力，所产生的泡沫绵密浓稠；具有较好的皮肤相容性；产品状态稳定，易于保存。
本发明采用的技术方案如下：一种洗涤剂组合物包括以下所述的组分，组分a，组分b组分c，其中组分a为脂肪酸盐、组分b为阴离子表面活性剂、组分c为两性离子表面活性剂、此外还包括pH调节剂、保湿剂、增稠剂、防腐剂以及水；其中组分a脂肪酸盐与两性离子表面活性剂的比例按组合物总重量的0.5：1-2：1。
所述组分a中的脂肪酸盐的结构一般为脂肪酸甲酯磺酸盐，月桂酸盐、异硬脂酸盐、肉豆蔻酸盐、棕榈酸盐、花生酸盐、油酸盐，这些之中，优选为选自月桂酸盐、肉豆蔻酸盐、棕榈酸盐、硬脂酸盐、油酸盐中的至少一种。
作为这些盐，可举出例如：钾盐等碱金属盐；铵盐；二乙醇胺盐、三乙醇胺盐等源自烷醇胺的铵盐；精氨酸盐、赖氨酸盐等碱性氨基酸盐等。
作为成分b阴离子表面活性剂，为除脂肪酸盐外的、且通常在皮肤上所使用的清洁物质，可举出例如月桂醇聚醚硫酸酯铵、月桂醇硫酸酯钠、月桂醇聚醚硫酸酯月桂酰肌氨酸钠、月桂酰燕麦氨基酸钠中的至少一种；烷基醚羧酸盐、烷基苯磺酸盐、烷磺酸盐、烯烃磺酸盐、甘油醚磺酸盐、α甲酯磺酸盐、磺基脂肪酸盐、烷基硫酸盐、脂肪醇醚硫酸盐、甘油醚硫酸盐、羟基混合醚硫酸盐、单烷基磺基琥酸盐、单烷基磺基琥珀酰胺酸盐、二烷基磺基琥珀酰胺酸盐、磺基三酸甘油酯、酰胺醚羧酸盐及其盐、脂肪酸羟乙基磺酸盐、脂肪酸肌氨酸盐、；酰基乳酸盐、酰基酒石酸盐、酰基天冬氨酸盐等的N-酰基氨基酸盐；蛋白质脂肪酸缩合物(基于小麦的植物产物)、烷基(醚)磷酸盐等。
成分C两性表面活性剂，只要是通常在皮肤清洁剂中使用的物质即可，可举成例如：十二烷基磺基甜菜碱、十二烷基乙氧基磺基甜菜碱、十二烷基羟丙基磺基甜菜碱、十二烷基磺丙基甜菜碱、十四烷酰胺丙基羟丙基磺基甜菜碱、癸烷基羟丙基磺基甜菜碱、十四烷基二羟乙基氧化胺、椰油酰胺丙基氧化胺等。
所述防腐剂选自甲基异噻唑啉酮、甲基氯异噻唑啉酮MCI、对羟基苯甲酸酯、苯氧乙醇、苯甲酸钠、乙基己基甘油、羟苯甲酯、1,2-己二醇中的至少一种。优选为苯氧乙醇、苯甲酸钠中的至少一种。
在一些实施方案中，所述组合的还包括助悬剂、pH调节剂、保湿剂、增稠剂、中的一种或多种。
pH调节剂，所述pH调节剂选自柠檬酸和柠檬酸钠、氢氧化钠、氢氧化钾和三乙醇胺中的一种或几种，优选为柠檬酸、柠檬酸钠中的至少一种。
所述保湿剂选自：丙三醇、丁二醇、聚乙二醇、丙二醇、已二醇、木糖醇(Xylitol)、聚丙二醇、山梨糖醇、甲基葡糖聚醚、甲壳质衍生物、海藻糖、银耳多糖、透明质酸钠等中的至少一种。
所述增稠剂选自PEG-120甲基葡糖二油酸酯、羟丙基甲基纤维素、氯化钠、氯化铵、硫酸钠、硫酸锌、PEG-90M、PEG-14M、PEG-150二硬脂酸酯中的至少一种。优选为PEG-14M、PEG-150二硬脂酸酯、氯化钠中的至少一种。
所述助悬剂选自改性玉米淀粉、二(氢化牛脂基)邻苯二甲酸酰胺、卡波姆、黄原胶、丙烯酸(酯)类共聚物及其混合物中的至少一种。优 选为改性玉米淀粉。
根据本申请组合物制备的皮肤清洁组合物，具有一定的保湿力度，皮肤相容性较好。
一下对本发明的组合物进行详细的说明：
本申请还提供了一种皮肤清洁组合物，包括按重量计的以下组分，
具体制备方法如下：
A)取适量纯化水，然后按比例依次加入，脂肪酸盐，阴离子表面活性剂，两性离子表面活性剂在60℃的条件下搅拌15-20分钟，混合均匀使之完全溶解；
B)之后加入本发明组合物中的保湿剂和增稠剂，防腐剂，补足纯化水，继续搅拌10-15分钟使之完全溶解；
对制备所的清洁产品进行表征，测定值得产品的性能。
实施例1
考察pH稳定性，用Brookfeild粘度计，pH计配比1～配比3考察ph稳定性，结果参见表1
根据实验结果可以看出，pH范围5～8内，清洁剂组合物的透光率和粘度无明显变化，pH稳定性较佳。
实施例2考察产品的起泡性以及泡沫免密程度。
利用配比1的产品1ml加入100ml水测量起泡时间以及一定时间能泡沫的体积，表征泡沫的稳定性。
| 时间 | 15s | 30s | 1min | 3min | 5min |
| 泡沫体积 | 630 | 730 | 720 | 700 | 685 |
从实验结果可以看出，本配比的产品，起泡较快，且在所检测的5min之内泡沫体积变化不大。即本产品起泡性优异且有一定持久性。
实施例3
考察产品室温下保存的稳定性
实施例4
考察产品的湿度，评估本申请的清洁产品的皮肤相容性。
利用配比1测量使用产品前后，皮肤表面的湿度，与现有同类市售清洁产品做对比
| 湿度测试 | 使用前 | 使用后 |
| 本申请配比1 | 16.4 | 20.3 |
| 现有市售产品 | 14.7 | 10.7 |
根据对比结果可以看出，本申请组合物有一定的保湿力度，皮肤相容性较好。
本发明的皮肤清洁组合物，泡沫良多，产生泡沫较快并且持久。同时自不同pH条件下形状稳定，在不同温度下清洁组合物的形状也无明显变化较为稳定。因此适用于洁面产品，洗手液，沐浴露，清洁泡沫等。
Claims (10)
- 一种皮肤清洁组合物，其特征在于，包括以下所述的组分：脂肪酸盐；阴离子表面活性剂，并且所述阴离子表面活性剂为除脂肪酸盐外的、且通常在皮肤上所使用的清洁物质；两性离子表面活性剂；此外还包括pH调节剂、保湿剂、增稠剂、防腐剂以及水；其中，所述脂肪酸盐与所述两性离子表面活性剂的比例按组合物总重量的0.5：1-2：1。
- 根据权利要求1所述的，一种皮肤清洁组合物，其特征在于，所述脂肪酸盐的结构一般为脂肪酸甲酯磺酸盐，月桂酸盐、异硬脂酸盐、肉豆蔻酸盐、棕榈酸盐、花生酸盐、油酸盐中的至少一种。
- 根据权利要求1所述的，一种皮肤清洁组合物，其特征在于，所述阴离子表面活性剂，可为月桂醇聚醚硫酸酯铵、月桂醇硫酸酯钠、月桂醇聚醚硫酸酯月桂酰肌氨酸钠、月桂酰燕麦氨基酸钠、α甲酯磺酸盐、磺基脂肪酸盐、烷基硫酸盐、脂肪醇醚硫酸盐、单烷基磺基琥珀酰胺酸盐、二烷基磺基琥珀酰胺酸盐、磺基三酸甘油酯、酰胺醚羧酸盐及其盐、脂肪酸羟乙基磺酸盐、脂肪酸肌氨酸盐、；酰基乳酸盐、酰基酒石酸盐、烷基(醚)磷酸盐中的至少一种。
- 根据权利要求1所述的，一种皮肤清洁组合物，其特征在于，所述两性表面活性剂，为十二烷基磺基甜菜碱、十二烷基乙氧基磺基甜菜碱、十二烷基羟丙基磺基甜菜碱、十二烷基磺丙基甜菜碱、十四烷酰胺丙基羟丙基磺基甜菜碱、癸烷基羟丙基磺基甜菜碱、十四烷基 二羟乙基氧化胺、椰油酰胺丙基氧化胺中的至少一种。
- 根据权利要求1所述的，一种皮肤清洁组合物，其特征在于，所述防腐剂选自甲基异噻唑啉酮、甲基氯异噻唑啉酮MCI、对羟基苯甲酸酯、苯氧乙醇、苯甲酸钠、乙基己基甘油、羟苯甲酯、1,2-己二醇中的至少一种。优选为苯氧乙醇、苯甲酸钠中的至少一种。
- 根据权利要求1所述的，一种皮肤清洁组合物，其特征在于，所述组合的还可以包括助悬剂、pH调节剂、保湿剂、增稠剂中的一种或多种。
- 根据权利要求7所述的，一种皮肤清洁组合物，其特征在于，所述pH调节剂选自柠檬酸和柠檬酸钠、氢氧化钠、氢氧化钾和三乙醇胺中的一种或几种。
- 根据权利要求7所述的，一种皮肤清洁组合物，其特征在于，所述保湿剂选自：丙三醇、丁二醇、聚乙二醇、丙二醇、已二醇、木糖醇、聚丙二醇、山梨糖醇、甲基葡糖聚醚、甲壳质衍生物、海藻糖、银耳多糖、透明质酸钠中的至少一种。
- 根据权利要求7所述的，一种皮肤清洁组合物，其特征在于，所述增稠剂选自PEG-120甲基葡糖二油酸酯、羟丙基甲基纤维素、氯化钠、氯化铵、硫酸钠、硫酸锌、PEG-90M、PEG-14M、PEG-150二硬脂酸酯中的至少一种。优选为PEG-14M、PEG-150二硬脂酸酯、氯化钠中的至少一种。
- 一种将权利要求1所述的皮肤清洁组合物在制备洁面产品，洗手液，沐浴露，清洁泡沫中的应用。
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| CN114796063A (zh) * | 2022-06-02 | 2022-07-29 | 广州一一生物技术有限公司 | 一种温和抑菌的洁面乳及其应用 |
| CN115505451A (zh) * | 2022-10-25 | 2022-12-23 | 温州康芝五金电器有限公司 | 一种电动剃须刀用抗菌润滑油及其制备方法 |
| CN115505451B (zh) * | 2022-10-25 | 2023-05-16 | 温州康芝五金电器有限公司 | 一种电动剃须刀用抗菌润滑油及其制备方法 |
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