WO2022097346A1 - 自動分析装置 - Google Patents

自動分析装置 Download PDF

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Publication number
WO2022097346A1
WO2022097346A1 PCT/JP2021/030163 JP2021030163W WO2022097346A1 WO 2022097346 A1 WO2022097346 A1 WO 2022097346A1 JP 2021030163 W JP2021030163 W JP 2021030163W WO 2022097346 A1 WO2022097346 A1 WO 2022097346A1
Authority
WO
WIPO (PCT)
Prior art keywords
reagent
flow path
unit
air
refrigerant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/030163
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
舜 栗城
敬道 坂下
和広 野田
将也 福田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi High Tech Corp
Original Assignee
Hitachi High Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi High Tech Corp filed Critical Hitachi High Tech Corp
Priority to JP2022560652A priority Critical patent/JP7465993B2/ja
Priority to CN202180065634.3A priority patent/CN116420079B/zh
Priority to EP21888899.8A priority patent/EP4242664A4/en
Priority to US18/029,427 priority patent/US20230366902A1/en
Publication of WO2022097346A1 publication Critical patent/WO2022097346A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00435—Refrigerated reagent storage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/14—Thermal energy storage

Definitions

  • the present invention relates to an automated analyzer.
  • An automatic analyzer is a device that analyzes components such as blood and urine collected from patients in clinical examinations. The analysis is performed by reacting various reagents with a sample and measuring discoloration, luminescence, etc. of the reaction solution.
  • This automated analyzer is equipped with a reagent cooler that keeps the reagent temperature within a certain range in order to maintain the quality of the reagents.
  • the temperature inside the reagent cooler is kept lower than the outside air.
  • the reagent cold storage is partially open for the purpose of dispensing reagents. Therefore, the inflow of outside air from the open portion causes dew condensation in the reagent cold storage, which causes a problem that the environment inside the cold storage is deteriorated.
  • Patent Document 1 discloses a technique for preventing the inflow of outside air and preventing dew condensation by sending cooled air from outside the reagent cold storage.
  • the present invention by cooling the air to be sent in a space separated from the reagent cooler, it is possible to design the structure with a high degree of freedom according to the target cooling performance, and it is possible to prevent dew condensation in the reagent cooler. It is an object of the present invention to provide an automatic analyzer that suppresses.
  • the inside of the reagent cold storage, the reagent cold storage for storing the reagent container for reacting the sample, the refrigerant cooling unit for cooling the reagent cold storage with the refrigerant, and the reagent cold storage are used.
  • An outside air intake section that takes in outside air to create positive pressure around the reagent cooler, and a blower that blows cooling air that is located outside the reagent cooler and cools the outside air with a refrigerant into the reagent cooler.
  • An automatic analyzer having a configuration including an air cooling unit is configured.
  • the inside of the reagent cold storage can be positively pressured by the blown air taken in from the outside and cooled by the blown air cooling unit, and the generation of dew condensation can be suppressed.
  • An automatic analyzer is a device that analyzes a sample such as blood or urine collected from a patient in a clinical examination.
  • a reagent cooler for storing a reagent container for reacting with a sample, a refrigerant cooling unit for cooling the reagent cooler with a refrigerant, and the inside of the reagent cooler with respect to the periphery of the reagent cooler.
  • the automatic analyzer 1 of this embodiment will be described with reference to FIG.
  • the automatic analyzer 1 is configured by connecting the analysis unit 2 and the control unit 3 with a communication line 4.
  • the control unit 3 is a device that controls each unit of the analysis unit 2, for example, a so-called computer.
  • the operator inputs the desired analysis content from the input unit such as the keyboard, mouse, and touch panel of the control unit 3, and confirms the analysis result on the output unit such as the liquid crystal display and the touch panel.
  • the analysis unit 2 is a device that analyzes the sample by measuring the issuance and discoloration caused by reacting the sample with the reagent for analysis, and is a sample transport path 10, a reagent cooler 20, an incubator 30, and a reaction solution measurement unit. Equipped with 40.
  • the sample transport path 10 is a mechanism for transporting the sample container 11 containing a sample such as blood or urine to the dispensing position of the sample dispensing unit 12.
  • the sample dispensing unit 12 sucks the sample from the transported sample container 11 and discharges the sample to the reaction container 13 installed in the incubator 30.
  • the dispensing tip 16 transported from the mounting rack 15 to the dispensing tip attachment / detachment section 13 by the transport section 14 is mounted. In order to prevent contamination during sample dispensing, the dispensing tip 16 is replaced at each dispensing.
  • the reagent cold storage 20 is a mechanism for storing the reagent container 21 containing the reagent for analysis at a low temperature, and has a reagent disk 22 and a reagent jacket 23.
  • the internal temperature of the reagent cooler 20 is maintained at, for example, 5 to 10 degrees.
  • the reagent disk 22 is mounted with the reagent container 21, and by rotating the axis in the vertical direction as a rotation axis, the reagent container 21 is moved to a predetermined position, for example, the dispensing position of the reagent dispensing section 24.
  • the reagent jacket 23 is a coating portion located on the outside of the reagent disc 23, and remains stationary even when the reagent disc 23 is rotated.
  • the incubator 30 is a mechanism for holding the sample at a constant temperature in order to promote the reaction of the mixed solution of the sample dispensed by the sample dispensing section 12 and the reagent dispensed by the reagent dispensing section 24.
  • the reaction vessel 13 is transported from the mounting rack 15 to the incubator 30 by the transport unit 14 prior to dispensing the specimens and reagents.
  • the reaction solution measuring unit 40 analyzes the components of the sample by measuring the discoloration, luminescence, etc. of the reaction solution dispensed by the reaction solution dispensing unit 41 from the reaction vessel 13 arranged in the incubator 30.
  • the measurement result of the reaction solution measuring unit 41 is displayed on an output unit such as a liquid crystal display or a touch panel of the control unit 3.
  • the reaction vessel 13 into which the reaction solution has been dispensed is removed by being transported from the incubator 30 to the mounting rack 15 by the transport unit 14.
  • FIG. 2 shows an outline of the configuration of the AA cross section of the automatic analyzer.
  • the reagent cooler 20 of this embodiment is connected to the refrigerant cooling unit 201 and the blown air cooling unit 202 by a plurality of flow paths 205 to 215. Further, the reagent cold storage 20 has a reagent suction hole 203, which is a hole for the reagent dispensing mechanism 24 to descend to the position where the reagent container 21 is installed.
  • the refrigerant cooling unit 201, the outside air intake unit 204, the blown air cooling unit 202, and the reaction liquid measuring unit 40 of the analysis unit 2 are controlled by the control unit 3.
  • the blower air cooling unit 202 is arranged so as to be horizontally aligned with the reagent cooler 20, and the refrigerant cooler 201 is located on the lower side of the reagent cooler 20 and the blower air cooler 202 in the vertical direction.
  • the blower unit 204 which is arranged and functions as an outside air intake unit, has a layout arranged on the lower side in the vertical direction of the reagent cooler 20 and the blower air cooling unit 202. This is for ease of implementation.
  • the refrigerant cooling unit 201 is a mechanism for sending and cooling a refrigerant such as cooling water.
  • the refrigerant sent from the refrigerant cooling unit 201 through the eighth flow path 205 circulates in the cooling target portion in the apparatus, and then returns to the refrigerant cooling unit 201 again through the sixth flow path 206.
  • the refrigerant whose temperature has risen due to the cooling of each part of the device is cooled again by the refrigerant cooling part 201.
  • the refrigerant cooling unit 201 releases the heat absorbed from the refrigerant to the outside of the device.
  • the cooled refrigerant is sent again through the eighth flow path 205 and repeatedly circulates in the apparatus.
  • the 7th flow path 207 is arranged in the space inside the reagent jacket 23.
  • the seventh flow path 207 is arranged so as to be in contact with the inner side surface of the reagent jacket 23.
  • the refrigerant flowing through the 8th flow path 205 and the 7th flow path 207 circulates in the space inside the reagent jacket 25 at least once. During that time, the refrigerant absorbs the heat of the air in the reagent cooler 20 to cool the space inside the cooler and the reagent container 21 installed in the cooler. After circulation, the refrigerant passes through the fourth flow path 208 and flows to the outside of the reagent cooler 20.
  • dew condensation occurs from the moisture contained in the air.
  • the generated dew condensation water is discharged from the third flow path 209 to the outside of the reagent cold storage 20 via the drain (discharge port).
  • the blast air cooling unit 202 includes a first flow path 211 that guides the cooling air into the reagent cold storage 20, and a second flow path 212 that discharges the dew condensation water generated by the blast air cooling unit 202 to the drain.
  • the reagent cold storage 20 is provided with a third flow path 209 for discharging the dew condensation water generated by the reagent cold storage to the drain, and the first flow path 211 and the second flow path 212 are formed so as to merge with the third flow path 209.
  • a water storage unit for storing dew condensation water is provided on the drain side of the point where the second flow path 212 and the third flow path 209 meet so that the cooling air does not leak to the outside.
  • the blower part 204 functions as an outside air intake part that sends air from the outside of the device to the inside. For example, by rotating a component such as a fan, air taken in from the outside of the device flows through the blower portion 204 and into the inside of the device. This air is called blown air.
  • the blower portion 204 is preferably arranged so that the intake surface does not face the ground in order to prevent suction of dust and foreign matter.
  • the blower air cooling unit 202 is a mechanism for cooling the air sent from the blower unit 204.
  • the blast air cooling unit 202 has a fifth flow path 210 that takes in the air flowing from the blast unit 204, a first flow path 211 that sends out the air to the outside of the blast air cooling unit after cooling, a fourth flow path 208 that takes in the refrigerant, and sends out the refrigerant. It is connected to the 6th flow path 206 and the 10th flow path 214 for discharging the dew condensation water. That is, the blast air cooling unit 202 includes a tenth flow path that serves as a blast path for guiding the outside air taken in from the blast unit 204, which is the outside air intake unit, to the first flow path 211.
  • the refrigerant that has passed through the reagent cooler 20 flows into the blower air cooling unit 202 through the fourth flow path 208.
  • the refrigerant flows through the space inside the blast air cooling unit 202, cools the air flowing in from the fifth flow path 210, and then flows to the outside of the blast air cooling unit 202 through the sixth flow path 206. After that, the refrigerant returns to the refrigerant cooling unit 201.
  • the first flow path 211 is connected to the second flow path 209 through which the dew condensation water discharged from the reagent cold storage 20 via the drain flows.
  • the cooled blast air flowing out from the blast air cooling unit 202 to the first flow path 211 passes through the second flow path 209 and flows into the reagent cooler 20.
  • the space inside the reagent cool box 20 is positively pressured by the blown air, and the pressure is higher than the air outside the device. As a result, the inflow of external air from the reagent suction hole 203 into the inside of the cool box is suppressed.
  • the blown air When the blown air is cooled by the refrigerant in the blown air cooling unit 202, the amount of moisture in the air is reduced due to the generation of dew condensation. Therefore, the blown air is sent to the reagent cold storage 20 in a dry state. As a result, the blown air has the effect of reducing the amount of dew condensation generated in the reagent cold storage 20 together with the suppression of the inflow of external air from the reagent suction hole 203.
  • the reagent cooler 20 and the blower air cooling unit 202 both use the circulating refrigerant for cooling, the blown air cooled by the blower air cooling unit 202 has the same temperature as the air in the reagent cooler 20. Become. Therefore, the influence of the inflow of blown air on the temperature control inside the reagent cooler 20 is suppressed.
  • Dew condensation occurs from the moisture contained in the air due to the cooling of the air inside the blower air cooling unit 202.
  • the generated dew condensation water is discharged from the second flow path 212 to the outside of the blower air cooling unit 202.
  • the 9th flow path 213 has a water storage unit that temporarily holds the above-mentioned dew condensation water, and is highlighted in FIG. 2 by diagonal lines.
  • the dew condensation water flowing from the reagent cold storage 20 and the blown air cooling unit 202 temporarily stays in the water storage unit before being discharged to the outside of the device.
  • the amount of water that the water storage section stays at reaches the upper limit the amount of water that exceeds the upper limit overflows from the water storage section and is discharged to the outside of the device.
  • the ninth flow path 213 is blocked by the dew condensation water remaining in the water storage section, and the air flowing from the blower section 204 does not flow out from the ninth flow path 213 to the outside of the device. Therefore, the reduction of the amount of air blown to the reagent cold storage 20 and the reduction of the positive pressure effect in the cold storage are suppressed.
  • the blower air cooling unit 202 has a cavity inside, and the cavity portion is connected to the fourth flow path 208 and the second flow path 206. Further, the blower air cooling unit 202 has a tenth flow path 214 which is a blower path arranged so as to pass through the cavity.
  • the tenth flow path 214 includes a partially spirally curved structure so as to increase the contact area with the refrigerant. Downstream from the spiral structure in the cavity, the 10th flow path 214 branches into a main stream connected to the 1st flow path 211 and a tributary connected to the 2nd flow path 212.
  • the tributary is a flow path having an inner diameter smaller than that of the main stream.
  • the refrigerant flowing into the blower air cooling unit 202 from the fourth flow path 208 passes through the cavity and flows out from the second flow path 206 to the outside.
  • the inflow amount is larger than the outflow amount, the amount of the refrigerant liquid in the cavity increases with the passage of time, and after a certain period of time, the inside of the cavity becomes filled with the circulating refrigerant.
  • the tenth flow path 214 When the cavity in the blower air cooling unit 202 is filled with the refrigerant, the tenth flow path 214 is in a state of being immersed in the circulating refrigerant.
  • the circulating refrigerant absorbs the heat of the blown air flowing through the tenth flow path 214, and the blown air is cooled. Dew condensation occurs from the blown air as it cools, and the dew condensation water is discharged through the second flow path 212.
  • the cooled blown air flows to the first flow path 211.
  • the dew condensation water generated by the cooling of the blown air passes through the tributary of the 10th flow path 214 and is discharged from the 2nd flow path 212.
  • the inclination of the spiral structure in the tenth flow path 214 and the tributary flow are directed downward in the vertical direction, so that the dew condensation water is easily discharged.
  • Example 1 as shown in FIG. 1, the blower air cooling unit 202 was arranged so as to be horizontally aligned with the reagent cooler 20.
  • the blower air cooling unit 202 fulfills its function by being connected to the reagent cooler 20 and the blower unit 204 at each flow path. Therefore, the blower air cooling unit 202 is not limited to the arrangement of the first embodiment.
  • the pressure loss in the process of the blown air flowing from the blower portion 204 to the reagent cooler 20 is large, the positive pressure performance in the reagent cooler 20 may deteriorate. Therefore, for the purpose of suppressing pressure loss, it is desirable that the length of the flow path of the blown air is short and the curve of the flow path is small.
  • blower air cooling unit 202 is arranged vertically below the reagent cooler 20. Further, the blower portion 204 is arranged near the outside of the device.
  • the length of the flow path of the blown air from the blower section 204 to the reagent cooler 20 is shortened, and the curve of the flow path is reduced, so that the pressure loss can be suppressed.
  • a part of the tenth flow path 214 has a spiral structure in order to increase the contact area between the flow path of the blow air and the refrigerant by placing it inside the blow air cooling unit 202.
  • the flow path can be designed to have a different shape according to the target cooling performance, and is not limited to the shape of the first embodiment. Therefore, as the third embodiment, the shape of the structure in which the internal structure of the blower air cooling unit 202 is simplified in order to suppress the pressure loss will be described.
  • the blower air cooling unit 202 has a cavity inside, and the cavity portion is connected to the fourth flow path 208 and the second flow path 206. Further, the blow air cooling unit 202 has a U-shaped eleventh flow path 215, which is an air passage arranged so as to pass through the hollow portion.
  • the eleventh flow path 215 branches into a main stream connected to the first flow path 211 and a tributary connected to the second flow path 212 in the cavity.
  • the tributary is a flow path having a diameter smaller than that of the main stream.
  • the refrigerant flowing into the blower air cooling unit 202 from the fourth flow path 208 passes through the cavity and flows out from the second flow path 206 to the outside.
  • the inflow amount is larger than the outflow amount, the amount of the refrigerant liquid in the cavity increases with the passage of time, and after a certain period of time, the inside of the cavity becomes filled with the circulating refrigerant.
  • the eleventh flow path 215 is in a state of being immersed in the circulating refrigerant.
  • the circulating refrigerant absorbs the heat of the blown air flowing through the 11th flow path 215, and the blown air is cooled. Dew condensation occurs from the blown air as it cools, and the dew condensation water is discharged through the second flow path 212. The cooled blown air flows to the first flow path 211.
  • the dew condensation water generated by the cooling of the blown air passes through the tributary of the 11th flow path 215 and is discharged from the 2nd flow path 212.
  • the U-shaped shape of the 11th flow path 215 and the tributaries facing downward in the vertical direction make it easy for dew condensation water to be discharged.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
PCT/JP2021/030163 2020-11-05 2021-08-18 自動分析装置 Ceased WO2022097346A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2022560652A JP7465993B2 (ja) 2020-11-05 2021-08-18 自動分析装置
CN202180065634.3A CN116420079B (zh) 2020-11-05 2021-08-18 自动分析装置
EP21888899.8A EP4242664A4 (en) 2020-11-05 2021-08-18 AUTOMATIC ANALYSIS DEVICE
US18/029,427 US20230366902A1 (en) 2020-11-05 2021-08-18 Automatic Analyzer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020184940 2020-11-05
JP2020-184940 2020-11-05

Publications (1)

Publication Number Publication Date
WO2022097346A1 true WO2022097346A1 (ja) 2022-05-12

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PCT/JP2021/030163 Ceased WO2022097346A1 (ja) 2020-11-05 2021-08-18 自動分析装置

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US (1) US20230366902A1 (https=)
EP (1) EP4242664A4 (https=)
JP (1) JP7465993B2 (https=)
CN (1) CN116420079B (https=)
WO (1) WO2022097346A1 (https=)

Cited By (1)

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EP4290240A1 (en) * 2022-06-06 2023-12-13 Sysmex Corporation Sample measuring apparatus and sample measuring method

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AT527700A1 (de) * 2023-11-10 2025-05-15 Meon Medical Solutions Gmbh & Co Kg Analysator mit Kühleinrichtung

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Also Published As

Publication number Publication date
JP7465993B2 (ja) 2024-04-11
CN116420079A (zh) 2023-07-11
CN116420079B (zh) 2025-10-28
EP4242664A1 (en) 2023-09-13
US20230366902A1 (en) 2023-11-16
EP4242664A4 (en) 2024-10-16
JPWO2022097346A1 (https=) 2022-05-12

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