WO2022065415A1 - 育毛剤 - Google Patents

育毛剤 Download PDF

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Publication number
WO2022065415A1
WO2022065415A1 PCT/JP2021/035009 JP2021035009W WO2022065415A1 WO 2022065415 A1 WO2022065415 A1 WO 2022065415A1 JP 2021035009 W JP2021035009 W JP 2021035009W WO 2022065415 A1 WO2022065415 A1 WO 2022065415A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
growth
present
palmitoyl dipeptide
hair growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/035009
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
荘太 中村
秀樹 高橋
佑紀美 中池
孝 辻
美帆 小川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adjuvant Holdings Co Ltd
RIKEN
Original Assignee
Adjuvant Holdings Co Ltd
RIKEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adjuvant Holdings Co Ltd, RIKEN filed Critical Adjuvant Holdings Co Ltd
Priority to TW110135956A priority Critical patent/TW202228759A/zh
Priority to US18/028,372 priority patent/US20230390356A1/en
Priority to KR1020237013795A priority patent/KR20230149286A/ko
Priority to JP2022519597A priority patent/JPWO2022065415A1/ja
Priority to CN202180072920.2A priority patent/CN116867504A/zh
Publication of WO2022065415A1 publication Critical patent/WO2022065415A1/ja
Priority to JP2022190829A priority patent/JP2023022204A/ja
Priority to JP2022190828A priority patent/JP2023025132A/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic

Definitions

  • the present invention relates to a hair restorer. More specifically, the present invention relates to a hair growth agent which is an external preparation containing palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine.
  • Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine is known as a component of cosmetic raw materials (see Patent Document 5). However, there is no report on the hair-growth effect of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine.
  • An object of the present invention is to provide a hair-growth agent having an excellent hair-growth effect.
  • the present inventors have exerted hair growth activity and scalp care effect by using palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine as an active ingredient. It has been found that the effect of promoting the production of FGF-7 in hair papilla cells is exerted, and the present invention has been completed.
  • the third means of the present invention for solving the above-mentioned problems is the first aspect of the present invention in which the content of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine is 0.005 to 10% by weight based on the whole.
  • the hair growth agent according to the means or the second means is the first aspect of the present invention in which the content of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine is 0.005 to 10% by weight based on the whole.
  • the seventh means of the present invention for solving the above-mentioned problems is the hair growth agent according to any one of the first to fourth means of the present invention, which is used for increasing the hair shaft diameter. be.
  • Another means of the present invention for solving the above-mentioned problems is a method for improving scalp symptoms, which comprises administering a scalp care agent, which is an external preparation containing palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, to a subject.
  • a scalp care agent which is an external preparation containing palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine
  • palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine as an active ingredient of a hair restorer which is an external preparation
  • hair shaft growth promotion and hair shaft elongation rate in hair, hair, eyebrows and / or eyelashes are achieved.
  • hair growth agents, scalp care agents, and FGF-7 production promoters for hair papilla cells which have an effect of improving hair shaft maximum length, increasing hair shaft diameter, and scalp care effect. Become.
  • ingredients such as additives that are permissible may be blended.
  • Ingredients such as this additive include, for example, excipients, stabilizers, odorants, bases, dispersants, diluents, anionic surfactants, amphoteric surfactants, nonionic surfactants, and cationic surfactants.
  • Activators anionic polymers, nonionic polymers, ethylene oxide / propylene oxide block copolymers, alcohols, emulsifiers, transdermal absorption promoters, pH adjusters, preservatives, colorants, fats and oils, mineral oils, etc. Oils, moisturizers, thickeners, polymers, film-forming agents, UV absorbers, cell activators, moisturizers, inorganic salts, functional beads and capsules, silicones, metal chelating agents, antioxidants, preservatives, Cooling agents, deodorants, pigments, dyes, fragrances, sugars, amino acids, vitamins, organic acids, organic amines, plant extracts, viscosity modifiers such as clay minerals and various polymers, but are limited to these. It is not something that is done.
  • the hair growth agent and scalp care agent of the present invention may contain known components having effects such as hair growth, hair growth, and hair growth.
  • the dose of the active ingredient per administration of the hair restorer and the scalp care agent in the means of the present invention can be adjusted so that the effects of the hair restorer and the scalp care agent of the present invention are exhibited.
  • the dose thereof can be, for example, 0.005 to 200 mg, specifically 0.05 to 100 mg, and more specifically 0.5 to 10 mg.
  • having a hair shaft growth promoting effect means having an advantageous action on hair stem growth promoting effect, and a characteristic showing a hair shaft growth promoting effect is referred to as "hair shaft growth promoting activity”. Further, “having a hair growth effect” means having an advantageous action on hair growth, and a characteristic showing a hair growth effect is referred to as "hair growth promoting activity”.
  • new hair grows from pores where hair growth is stopped or hair growth ability is reduced at a site where hair is not growing (hair shaft does not come out from the epidermis) or the number of hair is small. It can be used to promote this and increase the number of hairs, and more specifically to shorten the resting period in the hair cycle and / or to resume the stopped hair cycle.
  • the planned back body hair skin collection site of 7 to 8 week old C57BL / 6N mice was removed and bred for 12 to 14 days. Then, after euthanizing the hair-extracted C57BL / 6N mice by cervical spine dislocation, an appropriate amount of back body hair skin was collected from the planned back body hair skin collection site.
  • the transplanted wound into which the skin test piece derived from the back body hair skin was transplanted was covered with Nurse Van (registered trademark) (Sample Planet Co., Ltd., Japan) and surgical tape (3M Japan Ltd., Japan) as protective tapes. Protected the transplant wound.
  • the protective tape was removed 5 to 7 days after the transplantation, and the engraftment of the transplanted back body hair-derived skin test piece was visually or digitally determined by a digital microscope (Keyence Co., Ltd., Japan), and then follow-up was performed.
  • the Balb / c nu / nu mice transplanted with the hair group were coated with a palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine solution instead of a 60% ethanol aqueous solution according to the above method.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PCT/JP2021/035009 2020-09-24 2021-09-24 育毛剤 Ceased WO2022065415A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
TW110135956A TW202228759A (zh) 2020-09-24 2021-09-24 育毛劑
US18/028,372 US20230390356A1 (en) 2020-09-24 2021-09-24 Hair growth agent
KR1020237013795A KR20230149286A (ko) 2020-09-24 2021-09-24 육모제
JP2022519597A JPWO2022065415A1 (https=) 2020-09-24 2021-09-24
CN202180072920.2A CN116867504A (zh) 2020-09-24 2021-09-24 育毛剂
JP2022190829A JP2023022204A (ja) 2020-09-24 2022-11-29 毛乳頭細胞のｆｇｆ－７産生促進剤
JP2022190828A JP2023025132A (ja) 2020-09-24 2022-11-29 スカルプケア剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020-159776 2020-09-24
JP2020159776 2020-09-24

Publications (1)

Publication Number Publication Date
WO2022065415A1 true WO2022065415A1 (ja) 2022-03-31

Family

ID=80846554

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2021/035009 Ceased WO2022065415A1 (ja) 2020-09-24 2021-09-24 育毛剤

Country Status (6)

Country Link
US (1) US20230390356A1 (https=)
JP (3) JPWO2022065415A1 (https=)
KR (1) KR20230149286A (https=)
CN (1) CN116867504A (https=)
TW (1) TW202228759A (https=)
WO (1) WO2022065415A1 (https=)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009535310A (ja) * 2006-04-28 2009-10-01 ディーエスエム アイピー アセッツ ビー．ブイ． 基底膜のタンパク質の合成を刺激するための化粧品組成物
JP2013508322A (ja) * 2009-10-23 2013-03-07 リポテック，エセ．ア． 皮膚、粘膜および／または毛髪の治療および／またはケアに使用するペプチド、ならびに化粧料または医薬品組成物におけるその使用
JP2013525261A (ja) * 2009-04-22 2013-06-20 ディーエスエム アイピー アセッツ ビー．ブイ． 新規な組成物
CN105147534A (zh) * 2015-08-28 2015-12-16 深圳市维琪医药研发有限公司 一种用于皮肤修复的多肽组合物
US20150359830A1 (en) * 2013-01-30 2015-12-17 The Beauty Cartel, Llc. Hair Loss Compositions and Methods of Making and Using Same
JP2018501193A (ja) * 2014-10-28 2018-01-18 ルブリゾル アドバンスド マテリアルズ， インコーポレイテッド 発酵エキスを含有する化粧品組成物およびその使用
CN111329779A (zh) * 2020-03-23 2020-06-26 烟台中科恩吉科创新产业园管理有限公司 一种促毛发增长的活性肽组合物及其应用
WO2021075219A1 (ja) * 2019-10-18 2021-04-22 株式会社アジュバンコスメジャパン 育毛剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5028474U (https=) 1973-07-12 1975-04-01
US20170361130A9 (en) * 2008-05-23 2017-12-21 Pankaj Modi Stabilized and solubilized drug formulation for topical application and transdermal efficacy for cosmetic improvement and methods of formulation
US8591961B2 (en) * 2008-09-04 2013-11-26 Allergan, Inc. Aesthetic treatment of scars and aging skin
FR2932680B1 (fr) * 2008-06-19 2010-08-27 Clarins Lab Association de tiliroside et d'un peptide
JP2013151480A (ja) * 2011-12-26 2013-08-08 Rohto Pharmaceutical Co Ltd 外用組成物の安定化方法
WO2015157692A1 (en) * 2014-04-10 2015-10-15 Cgtn C.V. Skin care composition comprising plant extracts
CN106798655B (zh) * 2017-02-24 2020-04-10 深圳市维琪医药研发有限公司 一种具有丰胸作用的多肽组合物

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009535310A (ja) * 2006-04-28 2009-10-01 ディーエスエム アイピー アセッツ ビー．ブイ． 基底膜のタンパク質の合成を刺激するための化粧品組成物
JP2013525261A (ja) * 2009-04-22 2013-06-20 ディーエスエム アイピー アセッツ ビー．ブイ． 新規な組成物
JP2013508322A (ja) * 2009-10-23 2013-03-07 リポテック，エセ．ア． 皮膚、粘膜および／または毛髪の治療および／またはケアに使用するペプチド、ならびに化粧料または医薬品組成物におけるその使用
US20150359830A1 (en) * 2013-01-30 2015-12-17 The Beauty Cartel, Llc. Hair Loss Compositions and Methods of Making and Using Same
JP2018501193A (ja) * 2014-10-28 2018-01-18 ルブリゾル アドバンスド マテリアルズ， インコーポレイテッド 発酵エキスを含有する化粧品組成物およびその使用
CN105147534A (zh) * 2015-08-28 2015-12-16 深圳市维琪医药研发有限公司 一种用于皮肤修复的多肽组合物
WO2021075219A1 (ja) * 2019-10-18 2021-04-22 株式会社アジュバンコスメジャパン 育毛剤
CN111329779A (zh) * 2020-03-23 2020-06-26 烟台中科恩吉科创新产业园管理有限公司 一种促毛发增长的活性肽组合物及其应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD MINTEL; 11 July 2016 (2016-07-11), "All-in-One Shampoo", XP055913991, Database accession no. 4392485 *

Also Published As

Publication number Publication date
JP2023022204A (ja) 2023-02-14
JPWO2022065415A1 (https=) 2022-03-31
KR20230149286A (ko) 2023-10-26
JP2023025132A (ja) 2023-02-21
TW202228759A (zh) 2022-08-01
CN116867504A (zh) 2023-10-10
US20230390356A1 (en) 2023-12-07

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