JP2018501193A - 発酵エキスを含有する化粧品組成物およびその使用 - Google Patents
発酵エキスを含有する化粧品組成物およびその使用 Download PDFInfo
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- JP2018501193A JP2018501193A JP2017522622A JP2017522622A JP2018501193A JP 2018501193 A JP2018501193 A JP 2018501193A JP 2017522622 A JP2017522622 A JP 2017522622A JP 2017522622 A JP2017522622 A JP 2017522622A JP 2018501193 A JP2018501193 A JP 2018501193A
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Abstract
Description
驚くべきことに、本発明の出願人は、前述の問題の代替となる細菌起源の発酵エキスおよび菌体外多糖を見出した。
− 0.0000000001%(重量)〜20%(重量)の、Halomonas eurihalina種の菌株から排出された発酵エキスまたは菌体外多糖、
− 0.1%(重量)〜20%(重量)の、(INCI名)グリセリン、プロピレングリコール、ブチレングリコール、ペンチレングリコール、カプリリルグリコール、乳酸、尿素、ヒアルロン酸ナトリウムの群から選択される保湿剤、
− 0.1%(重量)〜20%(重量)の、(INCI名)ジメチコン、ステアリン酸グリセリル、カプリル酸/カプリン酸トリグリセリド、セテアリルアルコール、レシチン、C12〜15安息香酸アルキル、スクアラン、ラノリン、ベヘニルアルコール、トコフェロール酢酸エステル、パンテノール、Butyrospermum Parkiiバター、パルミチン酸レチニル、レチノールの群から選択される皮膚軟化剤または皮膚コンディショニング剤、
− 0.1%(重量)〜20%(重量)の、(INCI名)キサンタンガム、ラウレス硫酸ナトリウム、ステアリン酸(Steraric Acid)、ポリソルベート20、ポリソルベート80、ステアリルアルコール、セチルアルコール、ステアレス−2、セテアレス−20、コカミドプロピルベタインの群から選択される界面活性剤
を含有する。
abiaによって販売)、Actiporine 8G[INCI:Jania Rubensエキス]もしくはEPS Seafill[INCI:プランクトンエキス](Codifによって販売)、Novhyal Biotech G[INCI:アセチルグルコサミンリン酸二ナトリウム]もしくはRubixyl[INCI:ヘキサペプチド−47](Induchemによって販売)、Ca2+チャネルのアンタゴニスト、例えば限定されるものではないが、アルベリン、マンガンもしくはマグネシウム塩、ある特定の第二級もしくは第三級アミン、レチノールおよびその誘導体、イデベノンおよびその誘導体、補酵素Q10およびその誘導体、ボスウェル酸およびその誘導体、GHKおよびその誘導体および/もしくは塩、カルノシンおよびその誘導体、DNA修復酵素、例えば限定されるものではないが、光回復酵素もしくはT4エンドヌクレアーゼV、もしくは塩素チャネルアゴニスト、ならびに/またはこれらの混合物によって形成される群から選択される。
寄託番号LMG P−28571のHalomonas eurihalina種の菌株によって分泌される菌体外多糖を得る。
寄託番号LMG P−28571のHalomonas eurihalina種の菌株を、発酵槽中、32℃およびpH7.0で、水と、炭素供給源としての10g/Lのグルコースと、炭素および窒素供給源としての3g/Lの酵母エキスおよび3g/Lの麦芽エキスおよび5g/Lのエンドウマメペプトンと、9.8g/LのNaCl、1.7g/Lの塩化マグネシウム六水和物、2.5g/Lの硫酸マグネシウム七水和物、0.25g/Lの塩化カリウム、0.05g/Lの無水塩化カルシウム、0.05g/Lの重炭酸ナトリウム、臭化ナトリウムおよび塩化鉄の微量の塩を含有する塩溶液とを含有する培養培地で培養する。それを、指数関数的増殖状態にある前培養物からの、520nmにおける吸光度で0.2吸光度単位を接種し、発酵継続時間を、およそ40時間の培養まで延長する。培養物に、十分な空気を供給し、撹拌速度300〜600rpmで撹拌する。
寄託番号LMG P−28571のHalomonas eurihalina種の菌株から排出された菌体外多糖の物理化学的特徴付け。
Scrape−Loading染料移動によるヒトケラチノサイトHaCaT細胞株における細隙結合部細胞間連絡の増大の研究。
ヒト細隙結合部RT2PCRアレイを使用する、成人のヒト上皮ケラチノサイトにおけるRNA発現のモジュレーションの研究。
上皮−真皮細胞−細胞連絡に対する、寄託番号LMG P−28571のHalomonas eurihalina種の菌株によって生成された菌体外多糖の効果
免疫組織化学的アッセイを使用する、寄託番号LMG P−28571のHalomonas eurihalina種の菌株によって生成された菌体外多糖を用いる処理による、再構築されたヒト上皮上のコネキシンタンパク質の発現レベルの誘導。
寄託番号LMG P−28571のHalomonas eurihalina種の菌株によって生成された菌体外多糖を用いる処理による、in vitro閉経モデルにおけるコネキシン発現レベルの回復
寄託番号LMG P−28571のHalomonas eurihalina種の菌株によって生成された菌体外多糖の処理による、より高齢のケラチノサイトにおけるコネキシン発現レベルの回復
免疫組織化学的アッセイを使用する、寄託番号LMG P−28571のHalomonas eurihalina種の菌株によって生成された菌体外多糖を用いる処理による、再構築されたヒト上皮組織のin vitro閉経モデルにおけるコネキシンタンパク質発現レベルの回復。
寄託番号LMG P−28571のHalomonas eurihalina種の菌株によって生成された菌体外多糖の、閉経期モデルにおける上皮−真皮細胞−細胞連絡に対する効果
寄託番号LMG P−28571のHalomonas eurihalina種の菌株によって生成された初代ヒト皮下前脂肪細胞における脂質蓄積の増大の研究
Claims (15)
- 皮膚、粘膜、毛髪および/または爪の化粧的な非治療的な処置および/またはケアのための、Halomonas eurihalina種の菌株によって生成された発酵エキスの使用。
- 前記皮膚、粘膜、毛髪および/または爪の前記化粧的な非治療的な処置および/またはケアが、コラーゲン合成を刺激する処置、皮膚老化の処置および/または防止、皮膚皺の処置および/または防止、皮膚の張りを改善するためおよび/または皮膚の張りの喪失を防止するための処置、乾燥皮膚、ひび割れた唇、頭部粃糠疹、乾燥毛髪、脆弱な毛髪および/または爪の処置および/または防止である、請求項1に記載の使用。
- 前記皮膚、粘膜、毛髪および/または爪の前記化粧的な非治療的な処置および/またはケアが、該皮膚のコネキシンレベルを増大させる、請求項1に記載の使用。
- Halomonas eurihalina種の菌株によって生成された前記発酵エキスが、少なくとも10kDaの分子量を有する、前記請求項のいずれかに記載の使用。
- Halomonas eurihalina株によって生成された前記発酵エキスが、少なくとも1種の菌体外多糖を含有する、前記請求項のいずれかに記載の使用。
- 皮膚、粘膜、毛髪および/または爪の化粧的な非治療的な処置および/またはケアのための、Halomonas eurihalina種の菌株によって生成された菌体外多糖の使用。
- 前記菌体外多糖が、単糖であるラムノース、ガラクトース、グルコース、マンノースおよびD−グルコサミンを含有する、請求項5から6のいずれかに記載の使用。
- 前記菌体外多糖が、百分率の合計が100%を超えないという条件で、重量で、0.5%〜45%のラムノース、0.1%〜25%のガラクトース、0.5%〜30%のマンノース、合計で50%〜95%のグルコースおよびD−グルコサミン、0%〜10%のフコース、ならびに0%〜12%のグルクロン酸の組成を有している、請求項7に記載の使用。
- Halomonas eurihalina種の前記菌株が、寄託番号LMG P−28571のHalomonas eurihalina種の菌株である、前記請求項のいずれかに記載の使用。
- Halomonas eurihalina株によって生成された前記菌体外多糖の保持時間が、粒径8μm、細孔径50Åおよび長さ/内径300mm×7.5mmの水性サイズ排除クロマトグラフィーのためのクロマトグラフィーカラムならびに溶出液として水中0.1M酢酸ナトリウムを流速0.8ml/分で用いるHPLC分析で、4〜8.5分である、請求項6から9のいずれかに記載の使用。
- Halomonas eurihalina種の菌株によって生成された、化粧品として有効な量の発酵エキスまたは菌体外多糖、ならびに少なくとも1種の化粧品として許容される賦形剤および/または成分を含む化粧品組成物。
- 前記発酵エキスが、化粧品の送達系および/もしくは徐放系に組み込まれるか、または固体有機ポリマーもしくは固体無機支持体上に吸着される、請求項11に記載の化粧品組成物。
- クリーム、多重エマルション、溶液、液晶、無水組成物、水性分散液、油、乳液、バルサム、フォーム、ローション、ジェル、クリームジェル、ハイドロアルコール溶液、ハイドログリコール溶液、ヒドロゲル、リニメント、美容液、石けん、シャンプー、コンディショナー、セラム、多糖類膜、軟膏、ムース、ポマード、パウダー、棒状物質、ペンシル、スプレーまたはエアロゾルによって形成される群から選択される製剤中に提供される、請求項11から12のいずれかに記載の化粧品組成物。
- 布、不織布または医療デバイスに組み込まれる、請求項11から12のいずれかに記載の化粧品組成物。
- 前記化粧品として許容される賦形剤および/または成分が、神経細胞の開口分泌を阻害する薬剤、抗コリン作用剤、筋収縮を阻害する薬剤、老化防止剤、皺取り剤、保湿剤、保湿物質、アルファヒドロキシ酸、ベータヒドロキシ酸、モイスチャー化粧品、真皮もしくは上皮巨大分子の合成を刺激し、かつ/またはそれらの分解を阻害もしくは防止することができる薬剤、コラーゲン合成刺激剤、エラスチン合成刺激剤、デコリン合成刺激剤、ラミニン合成刺激剤、デフェンシン合成刺激剤、シャペロン合成刺激剤、cAMP合成刺激剤、AQP−3をモジュレートする薬剤、アクアポリン合成をモジュレートする薬剤、アクアポリンファミリーのタンパク質、ヒアルロン酸合成刺激剤、グリコサミノグリカン合成刺激剤、フィブロネクチン合成刺激剤、サーチュイン合成刺激剤、熱ショックタンパク質、熱ショックタンパク質合成刺激剤、ノクターニンの量を低減する薬剤、ノクターニン発現を阻害する薬剤、脂肪分解剤もしくは脂肪分解を刺激する薬剤、静脈強壮剤、PGC−1α発現をモジュレートする薬剤、PPARγの活性を阻害する薬剤、脂肪細胞のトリグリセリド含量を低減する薬剤、抗セルライト剤、脂肪細胞分化遅延剤、皮脂生成を減少させる薬剤、抗脂漏剤、艶消し剤、抗座瘡剤、制汗剤、抗炎症剤および/もしくは鎮痛剤、抗そう痒剤、鎮静剤、麻酔薬、アセチルコリン受容体凝集の阻害剤、アセチルコリンエステラーゼを阻害する薬剤、皮膚弛緩剤、メラニン合成の刺激剤もしくは阻害剤、ホワイトニング剤もしくは脱色剤、色素沈着促進剤、セルフタンニング剤、NOシンターゼ阻害剤、5α還元酵素阻害剤、リシルおよび/もしくはプロリルヒドロキシラーゼ阻害剤、抗酸化剤、フリーラジカルスカベンジャーおよび/もしくは抗大気汚染剤、反応性カルボニル種スカベンジャー、抗糖化剤、抗ヒスタミン剤、抗ウイルス剤、駆虫剤、乳化剤、皮膚軟化剤、有機溶媒、液体噴霧剤、皮膚コンディショナー、上皮加水分解酵素、ビタミン、アミノ酸、タンパク質、顔料もしくは着色剤、染料、バイオポリマー、ゲル化ポリマー、増粘剤、界面活性剤、軟化剤、乳化剤、結合剤、保存剤、目の下のたるみを低減もしくは処置することができる薬剤、角質除去剤、角質溶解剤、角質溶解剤、抗微生物剤、抗真菌剤、静真菌剤、殺菌剤、静菌剤、角質層構成成分の合成を刺激する薬剤、セラミド、脂肪酸、コラーゲン分解を阻害する薬剤、マトリックスメタロプロテイナーゼを阻害する薬剤、エラスチン分解を阻害する薬剤、セリンプロテアーゼを阻害する薬剤、線維芽細胞増殖を刺激する薬剤、ケラチノサイト増殖を刺激する薬剤、メラニン細胞増殖を刺激する薬剤、ケラチノサイト分化を刺激する薬剤、抗過角化症剤、面皰溶解剤、抗乾癬剤、DNA修復剤、DNA保護剤、幹細胞保護剤、安定剤、敏感肌の処置および/もしくはケアのための薬剤、引締め剤、抗ストレッチマーク剤、収斂剤、PAR−2の活性を阻害する薬剤、創傷治癒を刺激する薬剤、コアジュバント創傷治癒剤、上皮再形成を刺激する薬剤、コアジュバント上皮再形成剤、サイトカイン成長因子、毛細血管循環および/もしくは微小循環に作用する薬剤、血管新生を刺激する薬剤、血管透過性を阻害する薬剤、細胞代謝に作用する薬剤、真皮−上皮結合を改善する薬剤、発毛誘導剤、発毛阻害剤もしくは発毛遅延剤、抜け毛遅延剤、保存剤、香料、化粧品用および/もしくは吸収性および/もしくは体臭マスキング用のデオドラント、キレート剤、植物エキス、エッセンシャルオイル、海産物エキス、生物工学的プロセスから得られた薬剤、ミネラル塩、細胞エキス、日焼け止めならびに紫外Aおよび/もしくはB線および/もしくは赤外A線に対して活性な有機もしくは無機光防護剤、またはそれらの混合物によって形成される群から選択される、請求項11から14のいずれかに記載の化粧品組成物。
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JP6755863B2 (ja) | 2020-09-16 |
BR112017008726B1 (pt) | 2021-06-29 |
KR20170068605A (ko) | 2017-06-19 |
KR102610786B1 (ko) | 2023-12-05 |
AU2015338684A1 (en) | 2017-04-27 |
US10413501B2 (en) | 2019-09-17 |
US20170224602A1 (en) | 2017-08-10 |
EP3212291A1 (en) | 2017-09-06 |
BR112017008726A2 (pt) | 2018-01-30 |
CN107106480B (zh) | 2020-05-26 |
AU2015338684B2 (en) | 2020-08-20 |
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