WO2021255978A1

WO2021255978A1 - Non-rinsing-off-type sterilization cleaner composition

Info

Publication number: WO2021255978A1
Application number: PCT/JP2021/003354
Authority: WO
Inventors: 直渡辺; 愛堀越
Original assignee: ライオン株式会社
Priority date: 2020-06-15
Filing date: 2021-01-29
Publication date: 2021-12-23
Also published as: CN115666499A; KR20230024238A; JP2021195339A

Abstract

Provided is a non-rinsing-off-type sterilization cleaner composition comprising: (A) a quaternary ammonium compound; (B) at least one polymer selected from among a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer; and (C) at least one surfactant selected from among an amphoteric surfactant and a semi-polar surfactant, wherein the content of (D) a C1-C3 monohydric alcohol is less than 10 mass%.

Description

Non-rinse type disinfectant cleansing composition

The present invention relates to a non-rinse type bactericidal detergent composition.

Conventionally, a non-rinse type bactericidal cleaning agent composition used as a bactericidal cleaning agent for fingers and the like has bactericidal activity, is mild to the skin, and is desired to be excellent in storage stability and the like.

Ethanol preparations are often used as such bactericidal and cleansing agents for fingers (see, for example, Patent Document 1). However, ethanol has a problem that it has an alcoholic odor and irritation at the time of use, and there are problems such as dry hands after use.

Further, for the purpose of improving the handling of the usability of the sterilizing and cleaning agent, a gel-like hand sterilizing agent containing an anionic polymer mainly composed of a carboxyvinyl polymer has also been proposed (see Patent Document 2). However, the combination of the anionic polymer and a bactericidal disinfectant containing a quaternary ammonium compound having no alcohol irritation as a bactericidal component has a problem of reducing the bactericidal effect.

Therefore, it has excellent bactericidal activity and is less irritating to the hand skin during use, and the agent is easy to spread during application, the hand skin feels refreshed after application, the dispersibility of the agent, and the stability at low temperature storage. An excellent non-rinse type bactericidal detergent composition has not yet been provided, and its prompt development is strongly desired at present.

Japanese Unexamined Patent Publication No. 2011-153089 Japanese Unexamined Patent Publication No. 2011-144146

It is an object of the present invention to solve the above-mentioned problems in the past and to achieve the following objects. That is, the present invention has excellent bactericidal activity, low irritation to the hand skin during use, ease of spreading of the agent at the time of application, refreshing feeling of the hand skin after application, dispersibility of the agent, and It is an object of the present invention to provide a non-rinse type bactericidal detergent composition having excellent low temperature storage stability.

As a result of diligent studies to achieve the above object, the present inventors have made at least one polymer selected from (A) a quaternary ammonium compound and (B) a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer. And (C) at least one surfactant selected from an amphoteric surfactant and a semi-polar surfactant, and (D) a content of a monovalent alcohol having 1 to 3 carbon atoms by 10 mass by mass. By suppressing it to less than%, it has excellent bactericidal power and is less irritating to the hand skin during use, it is easy to spread the agent at the time of application, the refreshing feeling of the hand skin after application, the dispersibility of the agent, And, it has been found that a sterilizing and purifying agent composition of a non-rinse type having excellent low-temperature storage stability can be obtained, and the present invention has been completed.

The present invention is based on the above-mentioned findings by the present inventors, and the means for solving the above-mentioned problems are as follows. That is,
<1> (A) Quaternary ammonium compound and
(B) At least one polymer selected from a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer, and
(C) Containing at least one surfactant selected from amphoteric and semi-polar surfactants.
(D) A non-rinse type bactericidal detergent composition characterized in that the content of a monohydric alcohol having 1 to 3 carbon atoms is less than 10% by mass.
<2> Mass ratio of the sum of the content (mass%) of the component (A) and the content (mass%) of the component (B) to the content (mass%) of the component (C) [(A + B) / C ] Is a non-rinse type bactericidal cleansing composition according to <1>, which is 1 to 1.5.
<3> The content of the component (A) is 0.01% by mass to 0.2% by mass, the content of the component (B) is 0.1% by mass to 0.5% by mass, and (C). The non-rinse type bactericidal detergent composition according to any one of <1> to <2>, wherein the content of the component is 0.1% by mass to 0.4% by mass.
<4> The component (A) is a quaternary ammonium compound represented by the following general formula (1).

(However, in the general formula (1), R represents a linear or branched alkyl group or alkenyl group having 8 to 18 carbon atoms, and X is a halogen atom, an alkyl sulfate having 3 or less carbon atoms, and carbon. Represents any one selected from dialkyl sulfates of number 3 or less.)
A quaternary ammonium compound in which R is a linear or branched alkyl group or alkenyl group having 12 carbon atoms in the general formula (1) with respect to the total amount of the quaternary ammonium compound represented by the general formula (1). The non-rinse type bactericidal detergent composition according to any one of <1> to <3>, wherein the content of the above is less than 80% by mass.
<5> The non-rinse type bactericidal cleansing composition according to any one of <1> to <4>, excluding the bactericidal cleansing composition containing 3-iodo-2-propynylbutylcarbamate.

According to the present invention, it is possible to solve the above-mentioned problems in the past, achieve the above-mentioned object, have excellent bactericidal activity, have low irritation to the hand skin at the time of use, and easily spread the agent at the time of application. It is possible to provide a non-rinse type bactericidal detergent composition excellent in the refreshing feeling of the hand skin after application, the dispersibility of the agent, and the stability at low temperature storage.

(Non-washable type bactericidal detergent composition)
The non-rinse type bactericidal detergent composition of the present invention comprises (A) a quaternary ammonium compound, (B) at least one polymer selected from a carboxyvinyl polymer and an alkyl modified carboxyvinyl polymer, and (C). It contains at least one surfactant selected from amphoteric and semi-polar surfactants, and further contains other components as needed.
The non-rinse type bactericidal detergent composition of the present invention may contain (D) a monohydric alcohol having 1 to 3 carbon atoms, but the content thereof is less than 10% by mass.

<(A) Quaternary ammonium compound>
The quaternary ammonium compound as the component (A) is contained mainly for improving the bactericidal activity.

The quaternary ammonium compound of the component (A) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, benzethonium chloride, cetylpyridinium chloride, a compound represented by the following general formula (1) and the like can be selected. Can be mentioned. These may be used alone or in combination of two or more.

(However, in the general formula (1), R represents a linear or branched alkyl group or alkenyl group having 8 to 18 carbon atoms, and X is a halogen atom, an alkyl sulfate having 3 or less carbon atoms, and carbon. Represents any one selected from dialkyl sulfates of number 3 or less.)

When the quaternary ammonium compound of the component (A) contains the compound represented by the general formula (1), the general formula (1) with respect to the total amount of the quaternary ammonium compound represented by the general formula (1). In 1), the content of the quaternary ammonium compound in which R is a linear or branched alkyl group or alkenyl group having 12 carbon atoms is not particularly limited and may be appropriately selected depending on the intended purpose. It is preferably less than 80% by mass, more preferably 70% by mass or less.

Examples of the compound represented by the general formula (1) include benzalkonium chloride.

Among these, benzalkonium chloride and benzethonium chloride are preferable as the quaternary ammonium compound of the component (A) from the viewpoint of bactericidal activity.

As the quaternary ammonium compound of the component (A), a compound synthesized as appropriate may be used, or a commercially available product may be used.
Commercially available products of benzalkonium chloride as the quaternary ammonium compound of the component (A) include, for example, cation G-50 (manufactured by Sanyo Kasei Kogyo Co., Ltd.) and NIKKOL CA-101 (Nikko Chemicals Co., Ltd.) under the trade names. Etsu Chemical Co., Ltd.), Nissan cation (registered _trademark) M 2 -100R (NOF Co., Ltd.), Nissan cation (registered _trademark) F 2 -50R (NOF Co., Ltd.), and the like. Incidentally, Nissan cation (R) F ₂ -50R (NOF Corporation) is the total amount of the quaternary ammonium compound represented by the general formula (1), wherein in the general formula (1) R is carbon It is a product in which the content of the quaternary ammonium compound which is a linear alkyl group of several 12 is less than 80% by mass.
Commercially available products of benzethonium chloride as the quaternary ammonium compound of the component (A) include, for example, Ronzaguard benzethonium chloride (manufactured by Mitsubishi Chemical Foods Co., Ltd.) and benzethonium chloride (manufactured by Tokyo Chemical Industry Co., Ltd.) under the trade names. And so on.
Examples of commercially available products of cetylpyridinium chloride as the quaternary ammonium compound of the component (A) include cetylpyridinium chloride (CPC) (manufactured by Wako Pure Chemical Industries, Ltd.) under the trade name.

The content of the fourth ammonium compound of the component (A) is not particularly limited and may be appropriately selected depending on the intended purpose. The lower limit thereof is, for example, the non-rinse type bactericidal detergent composition. 0.005% by mass or more, 0.01% by mass or more, etc. are mentioned with respect to the total amount, and examples of the upper limit value thereof include 0.5% by mass or less, 0.2% by mass or less, and the like. However, from the viewpoint of bactericidal activity and irritation to the skin, 0.005% by mass to 0.5% by mass is preferable, and 0.01% by mass to the total amount of the non-rinse type sterilizing and cleaning agent composition. 0.2% by mass is more preferable. When the content of the quaternary ammonium compound of the component (A) is 0.005% by mass or more, the bactericidal activity is good, and when it is 0.5% by mass or less, the irritation to the hand skin is low, which is preferable. ..

<At least one polymer selected from (B) carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer>
The polymer as the component (B) is mainly contained to improve the spreadability of the agent at the time of application.

The polymer of the component (B) is at least one selected from a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer, but a carboxyvinyl polymer is preferable from the viewpoint of ease of spreading of the agent at the time of coating.

As the polymer of the component (B), a polymer appropriately synthesized may be used, or a commercially available product may be used.
Commercially available products of the carboxyvinyl polymer of the component (B) include, for example, Carbo-mer (registered trademark) 981 (manufactured by Japan Lubrizol Co., Ltd.) and Carbo-mer (registered trademark) ETD2050 (Japan Lubrizol Co., Ltd.). , Carbo-mer (registered trademark) 980 (manufactured by Japan Lubrizol Co., Ltd.), Carbo-mer (registered trademark) Ultraz10 (manufactured by Japan Lubrizol Co., Ltd.) and the like.
Commercially available products of the alkyl-modified carboxyvinyl polymer of the component (B) include, for example, Carbopol (registered trademark) 1382 (manufactured by Japan Lubrizol Co., Ltd.) and Carbopol (registered trademark) ETD2020 (Japan Lubrizol). (Made by Co., Ltd.), etc.

The content of the polymer of the component (B) is not particularly limited and may be appropriately selected depending on the intended purpose. The lower limit thereof is, for example, the total mass of the non-rinse type bactericidal detergent composition. In addition, 0.05% by mass or more, 0.1% by mass or more, and the like, and examples thereof include 1% by mass or less, 0.5% by mass or less, and the like at the time of application. From the viewpoint of ease of spreading of the agent and a refreshing feeling of the hand skin after application, 0.05% by mass to 1% by mass is preferable, and 0.1% by mass, based on the total amount of the non-rinse type sterilizing and cleaning agent composition. ~ 0.5% by mass is more preferable. When the content of the polymer of the component (B) is 0.05% by mass or more, the agent is easy to spread at the time of application, and when it is 1% by mass or less, the hand skin feels refreshed after application. It is good.

<(C) At least one surfactant selected from amphoteric and semi-polar surfactants>
The surfactant as the component (C) is mainly contained to improve bactericidal activity and low temperature storage stability.

The surfactant of the component (C) is at least one selected from amphoteric surfactants and semi-polar surfactants.

-Amphoteric surfactant-
The amphoteric tenside is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include imidazoline type amphoteric tenside agents. These may be used alone or in combination of two or more.

The alkylbetaine type amphoteric tenside is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include lauryldimethylaminoacetic acid betaine, coconut oil alkylbetaine and stearyldimethylaminoacetic acid betaine. These may be used alone or in combination of two or more.

The amide betaine-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. For example, lauric acid amide propyl betaine, coconut oil fatty acid amide propyl betaine, palm kernel oil fatty acid amide propyl betaine and the like can be selected. Can be mentioned. These may be used alone or in combination of two or more.

The sulfobetaine type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include lauryl hydroxysulfobetaine and lauramidopropyl hydroxysultaine. These may be used alone or in combination of two or more.

The imidazoline-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. For example, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-lauroyl- Examples thereof include N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-coconut oil fatty acid acyl-N'-carboxyethyl-N'-hydroxyethylethylenediamine sodium and the like.

-Semipolar surfactant-
The semi-polar surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include alkyldimethylamine oxide.

The alkyldimethylamine oxide is not particularly limited and may be appropriately selected depending on the intended purpose. For example, lauryldimethylamine oxide, coconut oil alkyldimethylamine oxide, myristyldimethylamine oxide, and lauric acid amidopropyldimethylamine oxide can be appropriately selected. And so on. These may be used alone or in combination of two or more.

Among these, the surfactant of the component (C) is preferably lauryldimethylamine oxide from the viewpoint of bactericidal activity and low temperature storage stability.

As the surfactant of the component (C), one synthesized appropriately may be used, or a commercially available product may be used.
As a commercially available product of the alkyl betaine type amphoteric surfactant as the amphoteric surfactant of the component (C), for example, under the trade name, Nissan Anon (registered trademark) BL (lauryldimethylaminoacetic acid betaine, manufactured by Nichiyu Co., Ltd.) ), Nissan Anon (registered trademark) BF (coconut oil dimethylaminoacetic acid betaine, manufactured by Nichiyu Co., Ltd.), NIKKOL AM-301 (lauryldimethylaminoacetic acid betaine, manufactured by Nikko Chemicals Co., Ltd.), Amogen S (lauryl betaine, first Industrial Pharmaceutical Co., Ltd.), Obazoline LB (lauryldimethylaminoacetic acid betaine, manufactured by Toho Kagaku Kogyo Co., Ltd.), Rycabion A-100 (lauryldimethylaminoacetic acid betaine solution, manufactured by Shin Nihon Rika Co., Ltd.), Anchtor 20BS (lauryldimethylamino) Betaine acetate, Kao Co., Ltd., Anchtor 24B (lauryldimethylaminoacetic acid betaine, Kao Co., Ltd.), Anchtor 86B (stearyldimethylaminoacetic acid betaine, Kao Co., Ltd.), Ricabion A-700 (stearyl betaine, Shin Nihon Rika) (Made by Co., Ltd.), etc.

As a commercially available product of the amide betaine type amphoteric surfactant as the amphoteric surfactant of the component (C), for example, under the trade name, NIKKOL AM-3130N (palm oil fatty acid amide propyl betaine solution, manufactured by Nikko Chemicals Co., Ltd.). , Nissan Anon (registered trademark) BDL-SF (amide propyl dimethylaminoacetic acid betaine laurate, manufactured by Nichiyu Co., Ltd.), Nissan Anon (registered trademark) BDF-SF (palm oil fatty acid amide propyldimethylaminoacetic acid betaine, Nichiyu Co., Ltd.) Company), Nissan Anon (registered trademark) BDC-SF (palm nuclear oil fatty acid amide propyl dimethylaminoacetic acid betaine, manufactured by Nichiyu Co., Ltd.), Anchtor 20AB (lauric acid amide propyl betaine solution, manufactured by Kao Co., Ltd.), Anhitor 55AB (Palm oil fatty acid amide propyl betaine liquid, manufactured by Kao Co., Ltd.), Softazoline CPB (palm oil fatty acid amide propyl betaine liquid, manufactured by Kawaken Fine Chemical Co., Ltd.), Softazoline LPB (lauric acid amide propyl betaine liquid, manufactured by Kawaken Fine Chemical Co., Ltd.) ), Softazoline PKPB (palm kernel oil fatty acid amide propyl betaine solution, manufactured by Kawaken Fine Chemical Co., Ltd.) and the like.

Commercially available products of the sulfobetaine-type amphoteric surfactant as the amphoteric surfactant of the component (C) are, for example, under the trade names of Anchtor 20HD (lauryl hydroxysulfobetaine solution, manufactured by Kao Co., Ltd.) and Softazoline LSB (Laura). Midopropyl hydroxysultaine, manufactured by Kawaken Fine Chemical Co., Ltd.) and the like.

As a commercially available product of the imidazoline-type amphoteric surfactant as the amphoteric surfactant of the component (C), for example, under the trade name, NIKKOL AM-101 (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole). Nium Betaine, manufactured by Nikko Chemicals Co., Ltd.), Nissan Anon (registered trademark) GLM-R-LV (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Nichiyu Co., Ltd.), Anchtor 20Y- B (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kao Co., Ltd.), Softazoline CH (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, Kawaken Fine Chemicals) (Manufactured by Kawaken Co., Ltd.), Softazoline CL (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kawaken Fine Chemical Co., Ltd.), Softazoline LHL (N-lauroyl-N'-carboxymethyl-N'- Hydroxyethylethylenediamine sodium solution, manufactured by Kawaken Fine Chemical Co., Ltd.), softazoline SFD (N-coconut oil fatty acid acyl-N'-carboxyethyl-N'-hydroxyethylethylenediamine sodium, manufactured by Kawaken Fine Chemical Co., Ltd.) and the like can be mentioned.

Commercially available products of alkyldimethylamine oxide as the semipolar surfactant of the component (C) include, for example, Anchtor 20N (lauryldimethylamine oxide solution, manufactured by Kao Co., Ltd.) and softazoline LAO (lauric acid amide) under the trade names. Propyldimethylamine oxide solution, manufactured by Kawaken Fine Chemicals Co., Ltd.), AX agent S (lauryldimethylamine oxide, manufactured by Lion Specialty Chemicals Co., Ltd.), Cadenax DMC-W (palm oil alkyldimethylamine oxide solution, manufactured by Lion Specialty Chemicals) Examples include Cadenax DM14D-N (Millistyldimethylamine Oxide, manufactured by Lion Specialty Chemicals Co., Ltd.) and Cadenax APA-12W (Lauryldimethylamine Oxide, manufactured by Lion Specialty Chemicals Co., Ltd.).

The content of the surfactant of the component (C) is not particularly limited and may be appropriately selected depending on the intended purpose. The lower limit thereof is, for example, the total mass of the non-rinse type bactericidal detergent composition. On the other hand, 0.05% by mass or more, 0.1% by mass or more, and the like, and examples thereof include 1% by mass or less, 0.4% by mass or less, and sterilization. From the viewpoint of power, low-temperature storage stability, refreshing feeling of the hand skin after application, and dispersibility of the agent, 0.05% by mass to 1% by mass with respect to the total amount of the non-rinse type sterilizing and cleaning agent composition. It is preferably 0.1% by mass to 0.4% by mass, and more preferably 0.1% by mass. When the content of the surfactant of the component (C) is 0.05% by mass or more, the bactericidal activity, the low temperature storage stability, and the dispersibility of the agent are good, and when it is 1% by mass or less, after application. The refreshing feeling of the hands is good.

<Mass ratio [(A + B) / C]>
The mass ratio of the sum of the content (mass%) of the component (A) and the content (mass%) of the component (B) to the content (mass%) of the component (C) [(A + B) / C ] Is not particularly limited and may be appropriately selected depending on the intended purpose. Examples of the lower limit value thereof include 0.1 or more and 1 or more, and examples thereof include the upper limit value thereof. Examples thereof include 10 or less, 5 or less, 1.5 or less, but 0.1 to 10 is preferable, 1 to 5 is more preferable, and 1 to 1.5 is particularly preferable from the viewpoint of bactericidal activity and dispersibility of the agent. .. When the mass ratio [(A + B) / C] is 0.1 or more, the bactericidal activity is good, and when it is 10 or less, the dispersibility of the agent is good.

<(D) Monohydric alcohol with 1 to 3 carbon atoms>
The non-rinse type bactericidal detergent composition may contain a monohydric alcohol having 1 to 3 carbon atoms as the component (D).

The monohydric alcohol having 1 to 3 carbon atoms of the component (D) is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include ethanol and isopropyl alcohol. These may be used alone or in combination of two or more.

As the monohydric alcohol having 1 to 3 carbon atoms as the component (D), an appropriately synthesized one may be used, or a commercially available product may be used.
Commercially available products of the monohydric alcohol having 1 to 3 carbon atoms as the component (D) include, for example, 95-degree synthetic specific alcohol (ethanol, manufactured by Shinwa Alcohol Sangyo Co., Ltd.) and isopropyl alcohol (Gordo Solvent Co., Ltd.). Made) and so on.

The content of the monovalent alcohol having 1 to 3 carbon atoms of the component (D) is less than 10% by mass with respect to the total amount of the non-rinse type bactericidal detergent composition from the viewpoint of irritation to the hand skin. However, 5% by mass or less is preferable, and 0.01% by mass or less is more preferable. When the content of the monohydric alcohol having 1 to 3 carbon atoms of the component (D) is 10% by mass or more, the irritation to the hand skin becomes strong.

<Other ingredients>
The non-rinse type bactericidal detergent composition of the present invention impairs the present invention in addition to the respective components (A), (B), (C), and (D). To the extent that it does not exist, components usually used in a bactericidal detergent composition or the like can be blended as other components, if necessary.

The other components are not particularly limited and may be appropriately selected depending on the intended purpose. For example, water, a water-soluble polymer other than the component (B), the component (A) and the component (C). Surfactants other than, oils, silicones, aromatic alcohols, lanolin derivatives, protein derivatives, vitamins and other agents, bactericides, preservatives, pH adjusters, oxidation other than the above (A) and (D) components. Preservatives, metal sequestering agents, UV absorbers, animal and plant extracts or derivatives thereof, pigments, fragrances and the like can be mentioned. These may be used alone or in combination of two or more.
The non-rinse type bactericidal detergent composition preferably does not contain 3-iodo-2-propynylbutylcarbamate from the viewpoint of irritation to the skin of the hands.

The pH adjuster is not particularly limited and may be appropriately selected depending on the intended purpose. However, the component (B) is neutralized, and the non-rinse type bactericidal detergent composition is thickened. It is preferable that the pH of the non-rinse type sterilizing and cleaning agent composition can be adjusted, and examples thereof include alkali metal hydroxides and alkanolamines. These may be used alone or in combination of two or more.
Examples of the alkali metal hydroxide include potassium hydroxide and sodium hydroxide.
Examples of the alkanolamine include triethanolamine, 2-amino-2-methyl-1-propanol, and diisopropanolamine.

The content of the other components with respect to the total amount of the non-rinse type bactericidal detergent composition is not particularly limited, and can be a content normally used as long as the effect of the present invention is not impaired.
The total content of the surfactants other than the component (A) with respect to the total amount of the non-rinse type bactericidal detergent composition is preferably 5% by mass or less from the viewpoint of the refreshing feeling of the hand skin after application. More preferably, it is 3% by mass or less.

-PH-
The pH of the non-rinse type bactericidal cleansing composition is not particularly limited and may be appropriately selected depending on the intended purpose. From the viewpoint of dispersibility of the agent and stability at low temperature storage, the pH at 25 ° C. is preferably 6 or more and 11 or less, and more preferably 7 or more and 8 or less.
The pH can be measured in a 25 ° C. environment by, for example, a glass electrode type hydrogen ion concentration indicator (device name: pH meter HM-30R type, manufactured by Toa DK Co., Ltd., electrode type: GST-5721). ..

-Production method-
The method for producing the non-rinse type bactericidal detergent composition is not particularly limited and may be appropriately selected depending on the intended purpose. For example, in an environment of room temperature (for example, 25 ° C.), the above-mentioned (for example, 25 ° C.) B) Add the ingredients little by little with stirring and disperse evenly. Next, after the pH adjuster is added and neutralized, the component (C) and the component (A) are mixed in this order with stirring, and each component is dissolved with stirring, if necessary. , The component (D) and the other components are added and mixed. After that, a method of appropriately adding the pH adjusting agent while stirring to adjust the pH to a predetermined value can be mentioned. Further, it is preferable to add water so that the total amount of the non-rinse type bactericidal detergent composition is 100% by mass.

The non-rinse type disinfectant detergent composition may be prepared using an apparatus. The device is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a stirring device having a shearing force and having a stirring blade capable of mixing the whole.
The stirring blade is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a propeller, a turbine and a disper.

-Use-
The use of the non-rinse type bactericidal detergent composition is not particularly limited and may be appropriately selected depending on the intended purpose, but can be suitably used as a hand skin disinfectant or the like. In addition, the non-rinse type bactericidal detergent composition can also be used for body parts other than hands. Examples of the application site include hospitals, long-term care facilities, kitchen applications, etc., and are suitably used at home.

Hereinafter, the present invention will be specifically described with reference to Examples, Comparative Examples, and Formulation Examples, but the present invention is not limited to these Examples and Formulation Examples.
The contents of each component described in Examples, Comparative Examples, and Formulation Examples are all values converted into pure content. However, for the component (D), a 95-degree synthetic specific alcohol (manufactured by Shinwa Alcohol Sangyo Co., Ltd.) was used, and the value in terms of absolute ethanol (content (% by mass) in terms of absolute ethanol) was described.

(Examples 1 to 20 and Comparative Examples 1 to 4)
As shown in the compositions and contents (% by mass) shown in Tables 1 to 5 below, the non-rinse type bactericidal detergent compositions of Examples 1 to 20 and Comparative Examples 1 to 4 were prepared based on the following production methods. did.

-Preparation of non-rinse type disinfectant detergent composition-
In an environment of 25 ° C., the component (B) was added little by little to an appropriate amount of water with stirring, and the mixture was uniformly dispersed to prepare a dispersion liquid. Next, after potassium hydroxide was added to the dispersion to neutralize it, the components (C) and (A) were mixed in this order with stirring, and each component was dissolved with stirring to prepare a solution. , Fragrance was added and mixed. Here, in Example 15, Example 16, and Comparative Example 4, the component (D) was added and mixed at the same time as the fragrance. Then, potassium hydroxide was appropriately added while stirring the solution to adjust the pH to a predetermined pH. Then, water was added so that the total amount of each sterilizing and cleaning agent composition was 100% by mass to obtain a non-rinse type sterilizing and cleaning agent composition of Examples 1 to 20 and Comparative Examples 1 to 4.
A propeller was used as the stirring blade, and stirring was performed using a three-one motor (trade name: HEIDON BL1200, manufactured by Shinto Kagaku Co., Ltd.). The pH was measured at 25 ° C. using a glass electrode type hydrogen ion concentration indicator (device name: pH meter HM-30R type, manufactured by Toa DK Co., Ltd., electrode type: GST-5721).

Regarding the obtained non-rinse type bactericidal detergent compositions of Examples 1 to 20 and Comparative Examples 1 to 4, based on the following evaluation methods, "bactericidal power", "ease of spreading the agent at the time of application", and "application". The "refreshing feeling of the hand skin", "dispersity", "low temperature storage stability", and "irritability to the hand skin" were evaluated. The evaluation results are shown in Tables 1 to 5 below.

<Bactericidal power>
Escherichia coli NBRC3972: Gram-negative bacteria, obtained from the Independent Administrative Institution Product Evaluation Infrastructure Organization) and Staphylococcus aureus NBRC12732: Gram-positive bacteria, obtained from the Independent Administrative Institution Product Evaluation Infrastructure Organization were used as target bacteria. The bactericidal activity of each non-rinse type bactericidal detergent composition of Examples 1 to 20 and Comparative Examples 1 to 4 was evaluated by a quantitative suspension method.
The Escherichia coli and Staphylococcus aureus were statically cultured at 37 ° C. for 18 to 24 hours under aerobic conditions using SCDLP agar medium (manufactured by Nihon Pharmaceutical Co., Ltd.). Next, scraping a suitable amount of colonies formed on SCDLP agar medium, suspended in saline (Otsuka Pharmaceutical Co., Ltd.), cell concentration: 10 was prepared such that 8 ^cfu / mL, the test bacterial suspension And said. In addition, cfu means a colony forming unit (colony forming unit).
Next, 0.05 mL of the test bacterial solution was added to 0.45 mL of each non-rinse type sterilizing and cleaning agent composition of Examples 1 to 20 and Comparative Examples 1 to 4, and mixed, and after 30 seconds, immediately mixed. The solution was diluted 10-fold with SCDLP liquid medium (manufactured by Nihon Pharmaceutical Co., Ltd.) and inactivated. Further, the inactivated solution was diluted 100-fold, 1,000-fold, and 10,000-fold with SCDLP liquid medium, and serial dilutions were performed every 10-fold. Then, 0.1 mL each of the inactivated solutions diluted to each concentration was inoculated (n = 3) on SCDLP agar medium (9 cm petri dish manufactured by Nippon Pharmaceutical Co., Ltd.), and aerobic conditions were obtained by the pour-mixed plate culture method. Underneath, the cells were statically cultured at 37 ° C. for 24 hours. After culturing, the total number of colonies formed was counted, and the number of surviving bacteria was measured. When no colonies were observed, the residual viable cell count was set to less than the detection limit of 10 cfu / mL. Based on the measured number of surviving bacteria, "bactericidal activity" was scored based on the following criteria. The "bactericidal activity" was evaluated based on the following evaluation criteria based on the average value of the scores.
-Criteria for "sterilizing power"-
5 points: The number of viable cells remaining is less than 10 cfu / mL (below the detection limit) 4 points: The number of viable cells remaining is 10 cfu / mL or more and less than 100 cfu / mL 3 points: The number of viable cells remaining is 100 cfu / mL or more 1 Less than 000 cfu / mL 2 points: Residual viable cell count is 1,000 cfu / mL or more and less than 10,000 cfu / mL 1 point: Residual viable cell count is 10,000 cfu / mL or more- "bactericidal activity" Evaluation Criteria-
⊚: The average value of the points is 4.0 points or more and 5.0 points or less ○: The average value of the points is 3.0 points or more and less than 4.0 points Δ: The average value of the points is , 2.0 points or more and less than 3.0 points ×: The average value of the points is less than 2.0 points.

<Easy to spread the agent at the time of application>
In an environment of 25 ° C., 10 specialized panelists (5 males and 5 females) applied 0.5 g of each non-rinse type bactericidal detergent composition of Examples 1 to 20 and Comparative Examples 1 to 4 in the palm of their hand. And the good spread of the agent when rubbed into the back of the hand was scored based on the following criteria. Based on the following evaluation criteria, the "easiness of spreading the agent at the time of application" was evaluated based on the average value of the points.
-Criteria for "ease of spreading the agent when applied"-
5 points: Feels very easy to stretch 4 points: Feels easy to stretch 3 points: Feels a little easy to stretch 2 points: Feels a little difficult to stretch 1 point: Feels difficult to stretch- "Easy to stretch the agent at the time of application" Evaluation Criteria-
⊚: The average value of the points is 4.0 points or more and less than 5.0 points ◯: The average value of the points is 3.0 points or more and less than 4.0 points Δ: The average value of the points is , 2.0 points or more and less than 3.0 points ×: The average value of the points is less than 2.0 points.

<Refreshing feeling of hand skin after application>
In an environment of 25 ° C., 10 specialized panelists (5 males and 5 females) applied 0.5 g of each non-rinse type bactericidal detergent composition of Examples 1 to 20 and Comparative Examples 1 to 4 in the palm of their hand. And the refreshing feeling after rubbing into the back of the hand was scored based on the following criteria. Based on the following evaluation criteria, the "fresh feeling of the hand skin after application" was evaluated based on the average value of the points.
-Criteria for "freshness of hands after application"-
5 points: Very refreshing feeling of hand skin 4 points: Feeling refreshing feeling of hand skin 3 points: Feeling refreshing feeling of hand skin 2 points: Feeling refreshing feeling of hand skin 1 point: Feeling refreshing feeling of hand skin I don't feel the refreshing feeling-Evaluation criteria of "Refreshing feeling of the hands after application"-
⊚: The average value of the points is 4.0 points or more and 5.0 points or less ○: The average value of the points is 3.0 points or more and less than 4.0 points Δ: The average value of the points is , 2.0 points or more and less than 3.0 points ×: The average value of the points is less than 2.0 points.

<Dispersity>
50 mL of each non-rinse type sterilizing and cleaning agent composition of Examples 1 to 20 and Comparative Examples 1 to 4 is placed in a glass screw vial bottle (trade name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.) having a capacity of 50 mL. One expert panelist visually observed the appearance of each of the three packed samples, and scored the "dispersibility" of the pharmaceutical product based on the following criteria. The "dispersity" was evaluated based on the following evaluation criteria based on the average value of the scores.
-Criteria for "dispersion"-
5 points: No agglomerates at all 4 points: Dispersed and almost no agglomerates in the composition and in a uniform state 3 points: Dispersed and a slight agglutination is seen in the composition, but there is no problem. Level 2 points: Aggregates are seen throughout 1 point: Precipitation of aggregates is seen-Evaluation criteria of "dispersity"-
⊚: The average value of the points is 4.0 points or more and 5.0 points or less ○: The average value of the points is 3.0 points or more and less than 4.0 points Δ: The average value of the points is , 2.0 points or more and less than 3.0 points ×: The average value of the points is less than 2.0 points.

<Low temperature storage stability>
50 mL of each non-rinse type sterilizing and cleaning agent composition of Examples 1 to 20 and Comparative Examples 1 to 4 is placed in a glass screw vial bottle (trade name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.) having a capacity of 50 mL. After filling 3 bottles at a time and storing in a constant temperature bath at -5 ° C for 1 month, one professional panelist visually observes the appearance of each non-rinse type bactericidal detergent composition, and based on the following criteria, The low-temperature storage stability was scored, and the "low-temperature storage stability" was evaluated based on the following evaluation criteria based on the average value of the scores.
-Criteria for "low temperature storage stability"-
5 points: No agglomeration at all 4 points: Almost no agglomeration 3 points: Slight agglomeration but no problem level 2 points: Agglomeration is seen throughout 1 point: Aggregation precipitation Seen-Evaluation criteria for "low temperature storage stability"-
⊚: The average value of the points is 4.0 points or more and 5.0 points or less ○: The average value of the points is 3.0 points or more and less than 4.0 points Δ: The average value of the points is , 2.0 points or more and less than 3.0 points ×: The average value of the points is less than 2.0 points.

<Irritation to hand skin>
In an environment of 25 ° C, 10 specialized panelists (5 males and 5 females) applied 0.5 g of each non-rinse type bactericidal detergent composition of Examples 1 to 20 and Comparative Examples 1 to 4 in the palm of the hand. And the irritation to the skin of the hand after rubbing into the back of the hand was scored based on the following criteria. "Irritation to hand skin" was evaluated based on the following evaluation criteria based on the average value of the scores.
-Criteria for "irritant to hand skin"-
5 points: No irritation to the hands 4 points: Almost no irritation to the hands 3 points: Slight irritation to the hands but no problem level 2 points: To the hands Feeling irritation 1 point: Feeling strong irritation to hand skin-Evaluation criteria for "irritability to hand skin"-
◎ ◎: The average value of the points is 4.5 points or more and 5.0 points or less ◎: The average value of the points is 4.0 points or more and less than 4.5 points ○: The average value of the points Is 3.0 points or more and less than 4.0 points. Δ: The average value of the points is 2.0 points or more and less than 3.0 points. ×: The average value of the points is less than 2.0 points. be

(Prescription Examples 1 to 10)
As shown in the compositions and contents (% by mass) shown in Tables 6 and 7 below, the non-rinse type sterilizing and cleaning agent compositions of Formulation Examples 1 to 10 were prepared.
Specifically, in Examples 1 to 20 and Comparative Examples 1 to 4, "-Preparation of a non-rinse type sterilizing and purifying agent composition-", the component (D) was not added and replaced with a fragrance in the following table. Except for the addition of common components other than potassium hydroxide and purified water shown in 6 and Table 7, "-Preparation of non-rinse type sterilizing and cleaning agent composition-" in Examples 1 to 20 and Comparative Examples 1 to 4. The non-rinse type bactericidal detergent composition of Formulation Examples 1 to 10 was prepared in the same manner as in the above.

Regarding the prepared non-rinse type bactericidal detergent compositions of Formulation Examples 1 to 10, "bactericidal power" and "easiness of spreading the agent at the time of application" were carried out by the same evaluation methods as in Examples 1 to 20 and Comparative Examples 1 to 4. "Sa", "Refreshing feeling of hand skin after application", "Dispersibility", "Stability at low temperature storage", and "Irritation to hand skin" were evaluated. The evaluation results are shown in Tables 6 and 7 below.

The raw materials used for the non-rinse type bactericidal detergent compositions used in Examples 1 to 20, Comparative Examples 1 to 4, and Formulation Examples 1 to 10 are as shown in Table 8 below.

The non-rinse type disinfectant cleansing composition of the present invention has excellent bactericidal activity, is less irritating to the hand skin during use, is easy to spread the agent during application, and refreshes the hand skin after application. Since it is excellent in feeling, dispersibility of the agent, and stability in low temperature storage, it can be suitably used for, for example, a hand skin disinfectant. In addition, the non-rinse type bactericidal detergent composition can also be used for body parts other than hands. Examples of the application site include hospitals, long-term care facilities, kitchen applications, etc., and are suitably used at home.

Claims

(A) Quaternary ammonium compound and
(B) At least one polymer selected from a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer, and
(C) Containing at least one surfactant selected from amphoteric and semi-polar surfactants.
(D) A non-rinse type bactericidal detergent composition characterized in that the content of a monohydric alcohol having 1 to 3 carbon atoms is less than 10% by mass.
The mass ratio [(A + B) / C] of the sum of the content (mass%) of the component (A) and the content (mass%) of the component (B) to the content (mass%) of the component (C) is The non-rinse type sterilizing and cleaning agent composition according to claim 1, wherein the composition is 1 to 1.5.
The content of the component (A) is 0.01% by mass to 0.2% by mass, the content of the component (B) is 0.1% by mass to 0.5% by mass, and the content of the component (C) is contained. The non-rinse type sterilizing and cleaning agent composition according to any one of claims 1 to 2, wherein the amount is 0.1% by mass to 0.4% by mass.
The component (A) is a quaternary ammonium compound represented by the following general formula (1).

(However, in the general formula (1), R represents a linear or branched alkyl group or alkenyl group having 8 to 18 carbon atoms, and X is a halogen atom, an alkyl sulfate having 3 or less carbon atoms, and carbon. Represents any one selected from dialkyl sulfates of number 3 or less.)
A quaternary ammonium compound in which R is a linear or branched alkyl group or alkenyl group having 12 carbon atoms in the general formula (1) with respect to the total amount of the quaternary ammonium compound represented by the general formula (1). The non-rinse type bactericidal detergent composition according to any one of claims 1 to 3, wherein the content of the bactericidal detergent is less than 80% by mass.
The non-rinse type bactericidal cleansing composition according to any one of claims 1 to 4, excluding the bactericidal cleansing composition containing 3-iodo-2-propynylbutylcarbamate.