CN111228145A - Mild antibacterial hand sanitizer and preparation method thereof - Google Patents
Mild antibacterial hand sanitizer and preparation method thereof Download PDFInfo
- Publication number
- CN111228145A CN111228145A CN202010098356.9A CN202010098356A CN111228145A CN 111228145 A CN111228145 A CN 111228145A CN 202010098356 A CN202010098356 A CN 202010098356A CN 111228145 A CN111228145 A CN 111228145A
- Authority
- CN
- China
- Prior art keywords
- phase
- hand sanitizer
- following components
- antibacterial hand
- components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 72
- 238000002360 preparation method Methods 0.000 title abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000002562 thickening agent Substances 0.000 claims abstract description 19
- 239000003093 cationic surfactant Substances 0.000 claims abstract description 10
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 9
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 9
- 239000002738 chelating agent Substances 0.000 claims abstract description 8
- 239000003906 humectant Substances 0.000 claims abstract description 8
- 239000006254 rheological additive Substances 0.000 claims abstract description 8
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 37
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 238000001816 cooling Methods 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 13
- 229920001577 copolymer Polymers 0.000 claims description 13
- 238000004140 cleaning Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 230000000249 desinfective effect Effects 0.000 claims description 7
- 229940044591 methyl glucose dioleate Drugs 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 238000005070 sampling Methods 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 5
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 5
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 4
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 4
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical group [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 claims description 4
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical group CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 claims description 4
- 230000009467 reduction Effects 0.000 claims description 4
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 4
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 claims description 3
- 235000019270 ammonium chloride Nutrition 0.000 claims description 3
- 230000000845 anti-microbial effect Effects 0.000 claims description 3
- 229960001950 benzethonium chloride Drugs 0.000 claims description 3
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 229920002545 silicone oil Polymers 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 235000010356 sorbitol Nutrition 0.000 claims description 3
- 229940073743 steareth-20 methacrylate Drugs 0.000 claims description 3
- CEYYIKYYFSTQRU-UHFFFAOYSA-M trimethyl(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)C CEYYIKYYFSTQRU-UHFFFAOYSA-M 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229940110830 beheneth-25 methacrylate Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- -1 myristylamine oxide Chemical compound 0.000 claims description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 6
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 239000006210 lotion Substances 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 description 16
- 238000004659 sterilization and disinfection Methods 0.000 description 16
- 238000012360 testing method Methods 0.000 description 14
- 239000000047 product Substances 0.000 description 13
- 206010040880 Skin irritation Diseases 0.000 description 8
- 239000000686 essence Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 231100000475 skin irritation Toxicity 0.000 description 8
- 230000036556 skin irritation Effects 0.000 description 8
- 241000222122 Candida albicans Species 0.000 description 7
- 241000588724 Escherichia coli Species 0.000 description 7
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 7
- 241000191967 Staphylococcus aureus Species 0.000 description 7
- 229940095731 candida albicans Drugs 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 238000005406 washing Methods 0.000 description 6
- 206010015150 Erythema Diseases 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 231100000321 erythema Toxicity 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 230000001953 sensory effect Effects 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 230000008719 thickening Effects 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical group [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 238000009736 wetting Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000005202 decontamination Methods 0.000 description 2
- 230000003588 decontaminative effect Effects 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 239000007863 gel particle Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- ONHFWHCMZAJCFB-UHFFFAOYSA-N myristamine oxide Chemical compound CCCCCCCCCCCCCC[N+](C)(C)[O-] ONHFWHCMZAJCFB-UHFFFAOYSA-N 0.000 description 2
- 229940104868 myristamine oxide Drugs 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000036620 skin dryness Effects 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229960003500 triclosan Drugs 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 125000000218 acetic acid group Chemical class C(C)(=O)* 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960002152 chlorhexidine acetate Drugs 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000005536 corrosion prevention Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/91—Graft copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a mild antibacterial hand sanitizer, which comprises the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: 0.01-0.1% of metal ion chelating agent, 1-5% of humectant, 2-15% of thickening agent, 4-10% of cationic surfactant and 17.2-82.54% of water, wherein the phase B comprises the following components: 6-30% of water, 3-15% of a rheology modifier and 0.5-2% of a nonionic surfactant, wherein the phase C comprises the following components: 0.05-0.2% of quaternary ammonium salt and 0.3-3% of nonionic thickener, wherein the phase D comprises the following components: 0.5-2% of pH regulator and 0.1-0.5% of essence; by the synergistic effect among multiple components, the skin care lotion has better bacteriostatic ability, is mild and comfortable, and is healthy and skin-care; the preparation method is simple, is easy for large-scale production, and has no pollution in the preparation process.
Description
Technical Field
The invention relates to the technical field of hand sanitizer, and particularly relates to a mild antibacterial hand sanitizer and a preparation method thereof.
Background
In human body parts, hands are the parts most contacted with harmful microorganisms such as bacteria, viruses and the like, and the mode of effectively preventing the infection and the spread of pathogenic bacteria is realized by frequently washing hands; the key point of the effectiveness of this method is well known, the existing hand sanitizer becomes an essential product in human life, and with the gradual increase of consumption level, the consumption of the hand sanitizer by people is no longer limited to strong detergency, and is more focused on using feeling and efficacy, the existing hand sanitizer consists of a cleaning agent, an emulsifier, a chelating agent, a viscosity control agent, a pH regulator, a colorant, a preservative and a synthetic antibacterial agent, care of hand skin is not paid attention, the hand skin is easy to dry and peel, the synthetic antibacterial agent is used as a bacteriostatic component, and like triclosan and chlorhexidine acetate are mostly adopted, although the hand sanitizer has strong bactericidal effect, the hand skin has irritation, and the triclosan and the like are reported to have carcinogenic risk and especially cause distortion for newborn babies, has potential threat to the health of the human body.
Disclosure of Invention
The invention mainly aims to overcome the defects and provide the mild antibacterial hand sanitizer and the preparation method thereof, and the mild antibacterial hand sanitizer can efficiently sterilize, inhibit bacterial breeding and effectively protect skin safety; the mild antibacterial hand sanitizer is mild and comfortable, is healthy and skin-care, can avoid skin irritation, skin dryness or allergy caused by the skin irritation, and has washing and skin moisturizing effects; the preparation method is simple, is easy for large-scale production, and has no pollution in the preparation process.
The invention is realized by the following technical scheme:
a mild antibacterial hand sanitizer comprises the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: 0.01-0.1% of metal ion chelating agent, 1-5% of humectant, 2-15% of thickening agent, 4-10% of cationic surfactant and 17.2-82.54% of water, wherein the phase B comprises the following components: 6-30% of water, 3-15% of a rheology modifier and 0.5-2% of a nonionic surfactant, wherein the phase C comprises the following components: 0.05-0.2% of quaternary ammonium salt and 0.3-3% of nonionic thickener, wherein the phase D comprises the following components: 0.5-2% of pH regulator and 0.1-0.5% of essence.
Further, the mild antibacterial hand sanitizer comprises the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: 0.03% of metal ion chelating agent, 2% of humectant, 8% of thickening agent, 7% of cationic surfactant and 49.44% of water, wherein the phase B comprises the following components: 20% of water, 10% of a rheology modifier and 1% of a nonionic surfactant, wherein the phase C comprises the following components: 0.13% of quaternary ammonium salt and 1% of nonionic thickener, wherein the phase D comprises the following components: 1.2 percent of pH regulator and 0.2 percent of essence.
Further, in the phase A component, the metal ion chelating agent is selected from disodium EDTA or tetrasodium EDTA;
the humectant is selected from silicone oil, glycerin, propylene glycol, 1, 3-butanediol or sorbitol; the use of the humectant enables the mild antibacterial hand sanitizer to achieve decontamination, cleaning and sterilization, and meanwhile, has a good moisturizing function, and can reduce hand dryness and keep the skin of hands intact.
The thickening agent is selected from acrylate/beheneth-25 methacrylate copolymer, acrylate/steareth-20 methacrylate copolymer, acrylate/steareth-50 acrylate copolymer or acrylate/cetyl polyether-methacrylate copolymer; the use of thickeners, which have shear-thinning properties, allows the mild antimicrobial hand sanitizer to be prepared with a thick but shear-thinned gel texture and has been found to impart a softer, smoother skin feel.
Meanwhile, the thickening agent has good suspension property, high compatibility with various components including cationic polymers, essences and the like, good rheology modification capability, bright appearance, capability of adjusting the viscosity of the hand sanitizer, reduction of sticky feeling of skin, better fluidity and pourability, simple and convenient liquid thickening agent, no need of neutralization and simple production process.
The cationic surfactant is selected from hexadecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide or octadecyl trimethyl ammonium chloride; the cationic surfactant has excellent adhesion and antistatic properties, and endows the mild antibacterial hand sanitizer with excellent wetting, cleaning, conditioning, softening, suspending and emulsifying properties.
In a proper concentration range, the acrylic polymer has good solubility in water, is dispersed in a system to form a polymer gel, the polymer gel has negative charges and is easy to react with a cationic surfactant with positive charges, when the amount of the cationic surfactant is proper, soluble gel particles are generated, and when the polymer gel contacts with salt on the skin or inorganic salt in tap water, the gel particles can be rapidly precipitated and combined into clusters to form flexible particles, the particles have proper size and hardness and are basically granular in a kneading state, so that the flexible particles have good friction effect in washing and can not damage the skin, the flexible particles can well replace the traditional hand sanitizer and adopt other types of abrasive particles to play a role in deeply cleaning the skin, when the mild antibacterial hand sanitizer is used, the mild pressure pump is extruded, and the skin is normally rubbed, the self-generated flexible particles with uniform particle sizes are uniformly distributed on the washed parts, and the deep cleaning effect can be achieved through friction.
Further, in the phase B component, the rheology modifier is selected from the group consisting of laurylamine oxide, myristylamine oxide, and cocoylamine oxide; the rheology modifier improves compatibility with the thickener and overall stability of the hand sanitizer.
The nonionic surfactant is selected from the group consisting of cocamide methyl MEA or cocamide MEA; the nonionic surfactant has the performances of foaming, foam stabilization, lime soap dispersion, thickening, gelation and the like, can be compounded with other surfactants to play excellent cleaning and wetting performances, and is suitable for personal care products such as shampoos, bubble baths, hand lotions and the like.
For example, cocamide methyl MEA is a natural novel nonionic surfactant, has the characteristics of excellent thickening, foaming and foam stabilizing, and has good wetting, decontamination and oil removal performances.
Further, in the phase C component, the quaternary ammonium salt is selected from benzalkonium chloride, benzethonium chloride, benzyl alkyl ammonium chloride or cetylpyridinium chloride; the quaternary ammonium salt as the bactericide has outstanding and broad-spectrum bactericidal efficacy, and can effectively and quickly sterilize so as to synergistically enhance the antibacterial ability.
The nonionic thickener is PEG-120 methyl glucose dioleate; PEG-120 methyl glucose dioleate is a derivative of natural glucoside, has good compatibility and solubility, excellent cooperativity, good thickening effect on surfactant systems which are difficult to thicken or have low content, enhances the thickening efficiency with mild amphoteric surfactants, does not reduce the foam of the surfactant systems, has no stimulation to eyes and skin, can reduce the overall irritation of the formula, and can provide fresh and comfortable skin feel.
Further, in the phase D component, the pH regulator is citric acid; citric acid is used as a pH regulator and is used for regulating the mild antibacterial hand sanitizer to be weakly acidic, and the pH value of the mild antibacterial hand sanitizer is 4.2-6.0, so that the mild antibacterial hand sanitizer conforms to the pH value most suitable for the skin surface of Asian human bodies, and the stimulation is reduced.
It will be appreciated that the mild antimicrobial hand sanitizer of the present invention may contain conventional adjunct ingredients such as colorants, fragrances or perfumes, as desired.
The invention also provides a method for preparing the mild antibacterial hand sanitizer, which comprises the following steps:
s1, accurately weighing the components in the phase A, the phase B, the phase C and the phase D, and cleaning and disinfecting required tools;
s2, sequentially adding the components in the phase A into a stirring pot, stirring and heating, continuously stirring, dissolving and uniformly mixing, and keeping the temperature;
s3, sequentially adding the components in the phase B into a stirring pot, and cooling after heat preservation;
s4, after the temperature reduction is finished, adding the components in the phase C, and uniformly mixing; sequentially adding the components in the phase D, uniformly stirring, and cooling;
and S5, after the temperature is reduced, obtaining the mild antibacterial hand sanitizer, sampling and detecting, and packaging finished products.
Further, in step S2, the heating temperature is raised to 83 ℃ to 87 ℃.
Further, in steps S2 and S3, the heat preservation time is 10 min.
Further, in step S4, the temperature is reduced to 45 ℃ after the temperature reduction is completed; in step S5, the temperature is reduced to 38 ℃.
Compared with the prior art, the invention has the following advantages:
1. the mild antibacterial hand sanitizer provided by the invention has the viscosity of 3000-10000MPA.s, is non-toxic, non-irritant, non-corrosive and obvious in sterilization effect, has bacteriostatic capability on staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa and the like, can kill over 99% of common pathogenic bacteria in a short time when hands are cleaned, has good sterilization rate, and meets the standard that the sterilization rate is more than or equal to 90% specified by national standards; the hand washing liquid has the function of nursing hand skin, is safe and stable, does not contain preservative components, adopts quaternary ammonium salt as a bactericide, has the effects of corrosion prevention and bacteria inhibition, has better skin feel after being used than other similar types of skin feels containing chlorine and acetic acids, does not have any uncomfortable feeling on hand skin after washing, and meets the market demand of consumers for pursuing natural washing and protecting products.
2. When the mild antibacterial hand sanitizer provided by the invention is matched with a hand sanitizer bottle with a pump head for use, the liquid pumped out by the pump head is directly in a gel state, so that the dosage is convenient to control; the moisture retention agent in the components can keep hand skin moist for a long time without hurting hands.
3. The mild antibacterial hand sanitizer provided by the invention has the advantages of safe and nontoxic raw materials, good stability, good bacteriostatic ability through a synergistic effect among multiple components, abundant raw material sources, easy biodegradation, safe use, good stability, low price and low cost; the preparation method is simple, the equipment is simple, and only simple stirring is needed.
Detailed Description
The following detailed description of the preferred embodiments of the present invention is provided to enable those skilled in the art to more clearly understand the advantages and features of the present invention and to clearly define the scope of the present invention.
Comparative example 1 the antibacterial hand sanitizer of example 1 of the antibacterial hand sanitizer of chinese patent CN 201610470577.8 was used.
Example 1
The embodiment provides a mild antibacterial hand sanitizer, which comprises the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: disodium EDTA 0.01%, propylene glycol 1%, acrylate/steareth-20 methacrylate copolymer 2%, tetradecyltrimethylammonium chloride 4%, and 82.54% water, the B phase comprising the following components: 6% of water, 3% of myristamine oxide and 0.5% of cocoamide methyl MEA, wherein the phase C comprises the following components: 0.05% of benzethonium chloride and 0.3% of PEG-120 methyl glucose dioleate, wherein the phase D comprises the following components: citric acid 0.5% and essence 0.1%.
The method for preparing the mild antibacterial hand sanitizer comprises the following steps:
s1, accurately weighing the components in the phase A, the phase B, the phase C and the phase D, and cleaning and disinfecting required tools;
s2, sequentially adding the components in the phase A into a stirring pot, stirring and heating to 83 ℃, continuously stirring, dissolving and uniformly mixing, and then preserving heat for 10 min;
s3, sequentially adding the components in the phase B into a stirring pot, preserving heat for 10min, and then beginning to cool;
s4, cooling to 45 ℃, adding the components in the phase C, and mixing uniformly; sequentially adding the components in the phase D, uniformly stirring, and cooling;
s5, cooling to 38 ℃ to obtain the mild antibacterial hand sanitizer, sampling and detecting, and packaging finished products.
Sensory indexes of the mild antibacterial hand sanitizer in the embodiment are as follows: viscous and opaque liquid, no delamination in appearance, no suspended matter or precipitate, no obvious mechanical impurity, no odor, and pH 6.0 (1: 10 water solution).
Example 2
The embodiment provides a mild antibacterial hand sanitizer, which comprises the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: tetrasodium EDTA 0.02%, sorbitol 1.5%, acrylate/steareth-50 acrylate copolymer 6%, cetyl trimethylammonium bromide 5.5%, and 65.53% water, the B phase comprising the following components: 12% of water, 7% of cocoamine oxide and 0.8% of cocamide MEA, wherein the phase C comprises the following components: 0.1% of benzyl alkyl ammonium chloride and 0.6% of PEG-120 methyl glucose dioleate, wherein the phase D comprises the following components: citric acid 0.8% and essence 0.15%.
The method for preparing the mild antibacterial hand sanitizer comprises the following steps:
s1, accurately weighing the components in the phase A, the phase B, the phase C and the phase D, and cleaning and disinfecting required tools;
s2, sequentially adding the components in the phase A into a stirring pot, stirring and heating to 84 ℃, continuously stirring, dissolving and uniformly mixing, and then preserving heat for 10 min;
s3, sequentially adding the components in the phase B into a stirring pot, preserving heat for 10min, and then beginning to cool;
s4, cooling to 45 ℃, adding the components in the phase C, and mixing uniformly; sequentially adding the components in the phase D, uniformly stirring, and cooling;
s5, cooling to 38 ℃ to obtain the mild antibacterial hand sanitizer, sampling and detecting, and packaging finished products.
Sensory indexes of the mild antibacterial hand sanitizer in the embodiment are as follows: viscous and opaque liquid, no layering in appearance, no suspended matter or precipitate, no obvious mechanical impurity, and no odor. The pH (1: 10 aqueous solution) was 5.6.
Example 3
The embodiment provides a mild antibacterial hand sanitizer, which comprises the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: 0.03% of disodium EDTA, 2% of glycerol, 8% of acrylate/behenyl polyether-25 methacrylate copolymer, 7% of hexadecyl trimethyl ammonium chloride and 49.44% of water, wherein the phase B comprises the following components: 20% of water, 10% of laurylamine oxide and 1% of cocamide MEA, wherein the phase C comprises the following components: benzalkonium chloride 0.13% and PEG-120 methyl glucose dioleate 1%, wherein the phase D comprises the following components: 1.2 percent of citric acid and 0.2 percent of essence.
The method for preparing the mild antibacterial hand sanitizer comprises the following steps:
s1, accurately weighing the components in the phase A, the phase B, the phase C and the phase D, and cleaning and disinfecting required tools;
s2, sequentially adding the components in the phase A into a stirring pot, stirring and heating to 85 ℃, continuously stirring, dissolving and uniformly mixing, and then preserving heat for 10 min;
s3, sequentially adding the components in the phase B into a stirring pot, preserving heat for 10min, and then beginning to cool;
s4, cooling to 45 ℃, adding the components in the phase C, and mixing uniformly; sequentially adding the components in the phase D, uniformly stirring, and cooling;
s5, cooling to 38 ℃ to obtain the mild antibacterial hand sanitizer, sampling and detecting, and packaging finished products.
Sensory indexes of the mild antibacterial hand sanitizer in the embodiment are as follows: viscous and opaque liquid, no layering in appearance, no suspended matter or precipitate, no obvious mechanical impurity, and no odor. The pH (1: 10 aqueous solution) was 5.5.
Example 4
The embodiment provides a mild antibacterial hand sanitizer, which comprises the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: disodium EDTA 0.07%, silicone oil 4%, acrylate/ceteth-methacrylate copolymer 12%, octadecyl trimethyl ammonium chloride 8.5%, and 32.77% water, the B phase comprising the following components: 25% of water, 12% of myristamine oxide and 1.5% of cocoamide methyl MEA, wherein the phase C comprises the following components: 0.16% of cetylpyridinium chloride and 2% of PEG-120 methyl glucose dioleate, wherein the phase D comprises the following components: 1.6 percent of citric acid and 0.4 percent of essence.
The method for preparing the mild antibacterial hand sanitizer comprises the following steps:
s1, accurately weighing the components in the phase A, the phase B, the phase C and the phase D, and cleaning and disinfecting required tools;
s2, sequentially adding the components in the phase A into a stirring pot, stirring and heating to 86 ℃, continuously stirring, dissolving and uniformly mixing, and then preserving heat for 10 min;
s3, sequentially adding the components in the phase B into a stirring pot, preserving heat for 10min, and then beginning to cool;
s4, cooling to 45 ℃, adding the components in the phase C, and mixing uniformly; sequentially adding the components in the phase D, uniformly stirring, and cooling;
s5, cooling to 38 ℃ to obtain the mild antibacterial hand sanitizer, sampling and detecting, and packaging finished products.
Sensory indexes of the mild antibacterial hand sanitizer in the embodiment are as follows: viscous and opaque liquid, no layering in appearance, no suspended matter or precipitate, no obvious mechanical impurity, and no odor. The pH (1: 10 aqueous solution) was 4.7.
Example 5
The embodiment provides a mild antibacterial hand sanitizer, which comprises the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: 0.1% of EDTA tetrasodium, 5% of 1, 3-butanediol, 15% of acrylate/behenyl polyether-25 methacrylate copolymer, 10% of hexadecyl trimethyl ammonium chloride and 17.2% of water, wherein the phase B comprises the following components: 30% of water, 15% of laurylamine oxide and 2% of cocamide methyl MEA, wherein the phase C comprises the following components: benzalkonium chloride 0.2% and a nonionic thickener 3%, wherein the phase D comprises the following components: 2 percent of citric acid and 0.5 percent of essence.
The method for preparing the mild antibacterial hand sanitizer comprises the following steps:
s1, accurately weighing the components in the phase A, the phase B, the phase C and the phase D, and cleaning and disinfecting required tools;
s2, sequentially adding the components in the phase A into a stirring pot, stirring and heating to 87 ℃, continuously stirring, dissolving and uniformly mixing, and keeping the temperature for 10 min;
s3, sequentially adding the components in the phase B into a stirring pot, preserving heat for 10min, and then beginning to cool;
s4, cooling to 45 ℃, adding the components in the phase C, and mixing uniformly; sequentially adding the components in the phase D, uniformly stirring, and cooling;
s5, cooling to 38 ℃ to obtain the mild antibacterial hand sanitizer, sampling and detecting, and packaging finished products.
Sensory indexes of the mild antibacterial hand sanitizer in the embodiment are as follows: viscous and opaque liquid, no layering in appearance, no suspended matter or precipitate, no obvious mechanical impurity, and no odor. The pH (1: 10 aqueous solution) was 4.2.
Example 6
And (3) stability test:
the physical and chemical indexes of the mild antibacterial hand sanitizer of the embodiments 1 to 5 are as follows:
1. heat stability, keeping at 48 + -2 deg.C, standing for 1 month, taking out, recovering to room temperature, observing, and making the product not turbid;
2. cold resistance and stability, the product is placed in a refrigerator at minus 18 +/-2 ℃ for 1 month, and is observed when taken out and restored to room temperature, no peculiar smell, no layering, no precipitation and no discoloration phenomena occur, and the product is not turbid;
3. high and low temperature stability, storing at-18 ℃ for 24h, storing at room temperature for 24h, storing in a thermostat at 48 ℃ for 24h, circulating for 5 times in sequence, and observing the stability, wherein the stability is reflected by no peculiar smell, no layering, no precipitation, no color change and no turbidity of the product.
Therefore, the stability of the mild antibacterial hand sanitizer provided by the invention meets the requirement.
Example 7
Skin irritation test:
the method comprises the following steps of removing hairs on two sides of the spinal cord of the rabbit, taking 0.5mL of the mild antibacterial hand sanitizer obtained in example 3 as a sample, smearing the sample on the skin on one side of the rabbit as a test object, covering the sample with two layers of gauze and one layer of cellophane, fixing the sample with a non-irritating adhesive tape and a bandage to serve as an experimental group, taking the skin on the other side of the rabbit as a group control, adopting a closed test, wherein the application time is 5h, and removing residual test objects with water after the test is finished.
The skin reaction results of the tested part are observed at 1, 24 and 48 hours after the test substances are removed respectively, and the skin reaction scores are carried out according to a skin irritation reaction scoring table. And judging the skin irritation intensity according to a skin irritation intensity grading standard table according to the highest integral mean value of each observation point of 1 hour, 24 hours and 48 hours.
Table 1: test results for skin irritation
| Animal numbering | 1 | 2 | 3 | 4 |
| Body weight (kg) | 2.0 (female) | 2.2 (female) | 2.1 (female) | 2.1 (female) |
| Grouping | Experimental control | Experimental control | Experimental control | Experimental control |
| Time of day | Erythema edema | Erythema edema | Erythema edema | Erythema edema |
| 1h | 0 0 0 0 | 0 0 0 0 | 0 0 0 0 | 0 0 0 0 |
| 24h | 0 0 0 0 | 0 0 0 0 | 0 0 0 0 | 0 0 0 0 |
| 48h | 0 0 0 0 | 0 0 0 0 | 0 0 0 0 | 0 0 0 0 |
As can be seen from the test results in Table 1, no local erythema and edema formation was observed on the skin of the test group, and no significant difference was observed compared with the control group, and no irritation was observed, thus showing that the mild antibacterial hand sanitizer provided by the present invention is mild and non-irritating.
Example 7
Testing strains: staphylococcus aureus (ATCC 6538), Escherichia coli (8099), Candida albicans (ATCC 10231), Pseudomonas aeruginosa (ATCC 15442).
The formula of the neutralizer is as follows: sodium thiosulfate 15g + Tween (80)25g + lecithin 4.0g + PBS 1000 mL.
Preparing a bacterial suspension: staphylococcus aureus (ATCC 6538), Escherichia coli (8099), Candida albicans (ATCC 10231) and Pseudomonas aeruginosa (ATCC 15442) cultured for 24 hours were each diluted with 1% by weight of peptone in 0.03mol/l Phosphate Buffered Saline (PBS) to prepare a bacterial suspension with a pH of 7.0 to 7.3 using 5ml of sterile distilled water.
Refer to QB/T2738-.
Quantitative sterilization test of suspension: taking 1.0ml of the bacterial suspension, placing the bacterial suspension in a sterile test tube, keeping the temperature of the sterile test tube constant in a water bath at 19-21 ℃, and then respectively adding 3.0 ml of the antibacterial hand sanitizer in the comparative example 1 and the mild antibacterial hand sanitizer in the examples 1-5 to mix uniformly. Acting for 1min, and mixing 0.5ml of the mixed solution with 4.5ml of neutralizing agent. And (3) after neutralization for 10min, taking 1.0ml of the solution or diluent, inoculating into a sterile plate, pouring a common nutrient agar culture medium, culturing in an incubator at 37 ℃ for 48h, counting the number of plate colonies, averaging the experiments for three times, taking an average value, and calculating the sterilization rate.
Table 2: experimental results of 1min sterilization rate
| Staphylococcus aureus | Escherichia coli | Pseudomonas aeruginosa | Candida albicans | |
| Comparative example 1 | 92.92% | 94.11% | 95.84% | 96.92% |
| Example 1 | 99.35% | 99.92% | 97.40% | 98.75% |
| Example 2 | 99.76% | 98.46% | 97.53% | 98.73% |
| Example 3 | 98.93% | 99.92% | 98.91% | 99.93% |
| Example 4 | 98.56% | 99.74% | 98.82% | 98.66% |
| Example 5 | 99.93% | 99.41% | 99.80% | 98.73% |
As can be seen from the sterilization experimental results in Table 2, the mild antibacterial hand sanitizer obtained in examples 1-5 has a good sterilization rate, and when the mild antibacterial hand sanitizer is used for 1 minute, the average sterilization rate of the mild antibacterial hand sanitizer obtained in examples 1-5 on staphylococcus aureus, pseudomonas aeruginosa, candida albicans and escherichia coli is more than 97.0%, and the standard that the sterilization rate is more than or equal to 90% and specified by the national standard is met, so that the requirements in the GB 19877.1-2005 special hand sanitizer sanitary specification are met.
The mild antibacterial hand sanitizer in example 3 is subjected to the quantitative sterilization test of the suspension, the action time is 2min, 5min, 10min, 20min and 40min respectively, and the sterilization rate is calculated.
Table 3: average sterilization Rate (%) at different time (min) of action
| Microorganisms | 2 | 5 | 10 | 20 | 40 |
| Staphylococcus aureus | 99.99% | 100.00% | 100.00% | 100.00% | 100.00% |
| Escherichia coli | 99.99% | 100.00% | 100.00% | 100.00% | 100.00% |
| Pseudomonas aeruginosa | 99.96% | 99.98% | 100.00% | 100.00% | 100.00% |
| Candida albicans | 99.97% | 99.99% | 100.00% | 100.00% | 100.00% |
The sterilization experimental results in table 3 show that the mild antibacterial hand sanitizer obtained in example 3 has a good sterilization rate, when the mild antibacterial hand sanitizer is used for 2 minutes, the average killing rate of staphylococcus aureus, pseudomonas aeruginosa, candida albicans and escherichia coli of the mild antibacterial hand sanitizer obtained in example 3 is more than 99.90%, and when the mild antibacterial hand sanitizer is used for 5min, 10min, 20min and 40min, the bacteriostatic effect is more obvious, so that the mild antibacterial hand sanitizer provided by the invention has the characteristics of high efficiency and long-term bacteriostasis.
The embodiment shows that the mild antibacterial hand sanitizer provided by the invention not only has good bacteriostatic ability, but also has strong stability; mild, comfortable, healthy and skin-care, can avoid the phenomena of skin irritation, skin dryness or allergy, has simple preparation method and simple equipment, and only needs simple stirring.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. A mild antibacterial hand sanitizer is characterized by comprising the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: 0.01-0.1% of metal ion chelating agent, 1-5% of humectant, 2-15% of thickening agent, 4-10% of cationic surfactant and 17.2-82.54% of water, wherein the phase B comprises the following components: 6-30% of water, 3-15% of a rheology modifier and 0.5-2% of a nonionic surfactant, wherein the phase C comprises the following components: 0.05-0.2% of quaternary ammonium salt and 0.3-3% of nonionic thickener, wherein the phase D comprises the following components: 0.5-2% of pH regulator and 0.1-0.5% of essence.
2. A mild antibacterial hand sanitizer according to claim 1, comprising the following components: phase A, phase B, phase C and phase D; the phase A comprises the following components in percentage by mass: 0.03% of metal ion chelating agent, 2% of humectant, 8% of thickening agent, 7% of cationic surfactant and 49.44% of water, wherein the phase B comprises the following components: 20% of water, 10% of a rheology modifier and 1% of a nonionic surfactant, wherein the phase C comprises the following components: 0.13% of quaternary ammonium salt and 1% of nonionic thickener, wherein the phase D comprises the following components: 1.2 percent of pH regulator and 0.2 percent of essence.
3. A mild antibacterial hand sanitizer according to claim 1 or 2, wherein in phase a component, said metal ion chelating agent is selected from the group consisting of disodium EDTA and tetrasodium EDTA; the humectant is selected from silicone oil, glycerin, propylene glycol, 1, 3-butanediol or sorbitol; the thickening agent is selected from acrylate/beheneth-25 methacrylate copolymer, acrylate/steareth-20 methacrylate copolymer, acrylate/steareth-50 acrylate copolymer or acrylate/cetyl polyether-methacrylate copolymer; the cationic surfactant is selected from hexadecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide or octadecyl trimethyl ammonium chloride.
4. A mild antibacterial hand sanitizer according to claim 1 or 2, wherein in phase B component, the rheology modifier is selected from the group consisting of laurylamine oxide, myristylamine oxide or cocoylamine oxide; the nonionic surfactant is selected from the group consisting of cocamide methyl MEA or cocamide MEA.
5. A mild antibacterial hand sanitizer according to claim 1 or 2, wherein in phase C component, said quaternary ammonium salt is selected from the group consisting of benzalkonium chloride, benzethonium chloride, benzylalkyl ammonium chloride and cetylpyridinium chloride; the nonionic thickener is PEG-120 methyl glucose dioleate.
6. A mild antibacterial hand sanitizer according to claim 1 or 2, wherein in phase D the pH adjuster is citric acid.
7. A process for preparing a mild antimicrobial hand sanitizer according to any one of claims 1 to 6 which comprises the steps of:
s1, accurately weighing the components in the phase A, the phase B, the phase C and the phase D, and cleaning and disinfecting required tools;
s2, sequentially adding the components in the phase A into a stirring pot, stirring and heating, continuously stirring, dissolving and uniformly mixing, and keeping the temperature;
s3, sequentially adding the components in the phase B into a stirring pot, and cooling after heat preservation;
s4, after the temperature reduction is finished, adding the components in the phase C, and uniformly mixing; sequentially adding the components in the phase D, uniformly stirring, and cooling;
and S5, after the temperature is reduced, obtaining the mild antibacterial hand sanitizer, sampling and detecting, and packaging finished products.
8. The method for preparing the mild antibacterial hand sanitizer according to claim 7, wherein in the step S2, the heating temperature is raised to 83-87 ℃.
9. The method of claim 7 wherein the incubation period is 10min in steps S2 and S3.
10. The method for preparing a mild antibacterial hand sanitizer according to claim 7, wherein in step S4, the temperature is reduced to 45 ℃; in step S5, the temperature is reduced to 38 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010098356.9A CN111228145A (en) | 2020-02-18 | 2020-02-18 | Mild antibacterial hand sanitizer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010098356.9A CN111228145A (en) | 2020-02-18 | 2020-02-18 | Mild antibacterial hand sanitizer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111228145A true CN111228145A (en) | 2020-06-05 |
Family
ID=70874947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010098356.9A Pending CN111228145A (en) | 2020-02-18 | 2020-02-18 | Mild antibacterial hand sanitizer and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111228145A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840167A (en) * | 2020-08-18 | 2020-10-30 | 广东一芙化妆品有限公司 | Natural plant bacteriostatic essential oil spray and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548983A (en) * | 2009-04-25 | 2009-10-07 | 广西佳华医疗卫生用品有限公司 | Skin disinfectant and method of producing the same |
| CN101766552A (en) * | 2010-01-20 | 2010-07-07 | 华南理工大学 | Washing-free antibacterial hand sanitizer and preparation method thereof |
| CN104188811A (en) * | 2014-07-30 | 2014-12-10 | 广州立白企业集团有限公司 | Foam type wash-free antibacterial liquid soap and using method thereof |
| CN104825356A (en) * | 2015-04-30 | 2015-08-12 | 威莱(广州)日用品有限公司 | Anti-bacterial hand-washing solution and preparation method thereof |
-
2020
- 2020-02-18 CN CN202010098356.9A patent/CN111228145A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548983A (en) * | 2009-04-25 | 2009-10-07 | 广西佳华医疗卫生用品有限公司 | Skin disinfectant and method of producing the same |
| CN101766552A (en) * | 2010-01-20 | 2010-07-07 | 华南理工大学 | Washing-free antibacterial hand sanitizer and preparation method thereof |
| CN104188811A (en) * | 2014-07-30 | 2014-12-10 | 广州立白企业集团有限公司 | Foam type wash-free antibacterial liquid soap and using method thereof |
| CN104825356A (en) * | 2015-04-30 | 2015-08-12 | 威莱(广州)日用品有限公司 | Anti-bacterial hand-washing solution and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840167A (en) * | 2020-08-18 | 2020-10-30 | 广东一芙化妆品有限公司 | Natural plant bacteriostatic essential oil spray and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109381480B (en) | Compound polyhexamethylene biguanide disinfectant and preparation method thereof | |
| CN100374099C (en) | Antimicrobial composition | |
| CN105623903A (en) | High-dirt-removing-power antibacterial protective laundry detergent and preparation method thereof | |
| CN103118655A (en) | Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants | |
| CA2098429A1 (en) | Preserved wet wipes | |
| CA2267678A1 (en) | Germicidal composition | |
| EP2346324A2 (en) | Antimicrobial composition and methods of making and using same | |
| CN111110577B (en) | Mild mite-removing itching-relieving shower gel and preparation method thereof | |
| CN107454822A (en) | For the method for disinfecting surface and suitable for composition therein | |
| CN111437206A (en) | Antibacterial and disinfectant hand sanitizer containing nano-silver and preparation method thereof | |
| CN109125096A (en) | Foam liquid soap and preparation method thereof | |
| CN111249169A (en) | Wash-free disinfection mousse composition | |
| CN112494348A (en) | Antibacterial no-clean hand sanitizer and preparation method and application thereof | |
| CN107753310A (en) | A kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates and preparation method thereof of new type of safe | |
| CN104430333A (en) | Concentrated disinfectant for washhouse and preparation method of concentrated disinfectant | |
| CN109706000A (en) | A kind of long acting antibiotic liquid detergent and preparation method thereof | |
| CN111228145A (en) | Mild antibacterial hand sanitizer and preparation method thereof | |
| KR20150001021A (en) | Antiseptic Composition without Skin Irritation, and Goods Containing the Same | |
| CN113694082A (en) | Hypochlorous acid disinfectant and preparation method thereof | |
| KR20100078777A (en) | Rapid antifungal handwash composition | |
| CN111109259A (en) | Composite sterilizing disinfectant | |
| CN101548683B (en) | Liquid disinfectant and method of producing the same | |
| CN108130222A (en) | A kind of glasses cleaning agent and preparation method thereof | |
| CN109125122A (en) | A kind of washing-free antibacterial hand sanitizer and preparation method thereof | |
| CN105255620A (en) | Leather detergent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200605 |