WO2021240853A1 - 自動試料注入装置 - Google Patents

自動試料注入装置 Download PDF

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Publication number
WO2021240853A1
WO2021240853A1 PCT/JP2020/046721 JP2020046721W WO2021240853A1 WO 2021240853 A1 WO2021240853 A1 WO 2021240853A1 JP 2020046721 W JP2020046721 W JP 2020046721W WO 2021240853 A1 WO2021240853 A1 WO 2021240853A1
Authority
WO
WIPO (PCT)
Prior art keywords
solvent
setting unit
sample injection
injection device
user
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2020/046721
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
大貴 福島
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Priority to US17/926,303 priority Critical patent/US12313608B2/en
Priority to CN202080100541.5A priority patent/CN115516307B/zh
Priority to JP2022527488A priority patent/JP7452643B2/ja
Publication of WO2021240853A1 publication Critical patent/WO2021240853A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling
    • G01N2035/0094—Scheduling optimisation; experiment design
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1032—Dilution or aliquotting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems

Definitions

  • the present invention relates to an automatic sample injection device for injecting a sample into an analyzer such as a gas chromatograph.
  • an automatic sample injection device that automatically executes a sample injection operation into the analyzer is used.
  • cleaning using a predetermined solvent of a sampling mechanism such as a syringe for inhaling and dispensing liquid and co-injection using an injection sample are performed. It is designed to perform washing.
  • the present invention has been made in view of the above problems, and an object of the present invention is to make it possible to arbitrarily set a method such as a cleaning operation.
  • Patent Document 1 proposes that in an analysis system, parameters related to analysis results and the like can be set on a simplified interface, and each device is controlled according to the set parameters. Although it is possible to set a method for achieving the effect requested by the user by using the proposed function, it is not possible to realize the arrangement of the solvent suitable for the set method by itself.
  • the automatic sample injection device is configured to inject a sample into the analyzer by a sampling mechanism that inhales and dispenses a solvent, and each of the plurality of automatic sample injection devices is contained in a vial.
  • a method setting unit configured to set a method of a predetermined operation using a solvent based on a solvent placement location where the solvent is placed, and information input by the user, and a method setting unit configured to set the solvent placement location.
  • a method setting unit configured to set a method of a predetermined operation using a solvent based on information input by a user, and a method setting unit configured to set a method of a predetermined operation, and a solvent placement location are arranged. Since the solvent arrangement setting unit for setting the number of solvents to be used and the types thereof is provided, a method of a predetermined operation such as a cleaning operation can be arbitrarily set.
  • the automatic sample injection device includes a sampling mechanism 2, a turret 4, a control unit 6, and an arithmetic control device 8.
  • the sampling mechanism 2 includes a syringe 10 and a driving unit 12 for driving the syringe 10.
  • the sampling mechanism 2 is for inhaling and dispensing the sample and the solvent from the vial arranged on the turret 4 by the syringe 10.
  • Turret 4 is a disk-shaped table.
  • a plurality of vial placement locations are provided on the turret 4 on the same circumference, including a solvent placement location 14 for arranging the plurality of vials containing the solvent.
  • the turret 4 may be provided with a sample placement location for arranging vials for accommodating the sample. Further, the sample placement place may be provided in a place different from the place on the turret 4.
  • the control unit 6 is a function realized by an electronic circuit equipped with a CPU (central processing unit) or the like.
  • the control unit 6 is configured to control the sampling mechanism 2 and the turret 4 to perform analysis of each sample arranged in the turret 4.
  • the arithmetic control device 8 provided so as to be able to communicate with the control unit 6 has a function of setting a method of a predetermined operation using a solvent arranged on the turret 4, such as a cleaning operation of the sampling mechanism 2 before and after sample injection. It is provided.
  • the control unit 6 controls the sampling mechanism 2 and the turret 4 so that the cleaning operation or the like is executed according to the method set in the arithmetic control device 8.
  • the arithmetic control device 8 can be realized by a general-purpose personal computer or a dedicated computer.
  • a display 22 for displaying various information and an input device 24 such as a keyboard are electrically connected to the arithmetic control device 8.
  • the arithmetic control device 8 is provided with a method setting unit 16, a recommended method presentation unit 18, and a solvent arrangement setting unit 20.
  • the method setting unit 16, the recommended method presentation unit 18, and the solvent arrangement setting unit 20 are functions obtained by the CPU in the arithmetic control device 8 executing a predetermined program.
  • the method setting unit 16 is configured to set a method such as a cleaning operation based on the information input by the user via the input device 24. Specifically, when the user inputs an instruction to edit the method, the method setting unit 16 displays the method edit screen on the display 22, and when the user inputs necessary information on the method edit screen, the method is used. The setting unit 16 sets the method based on the input information.
  • the cleaning operation of the sampling mechanism 2 is an operation of sucking the solvent from the vial 14 on the turret 4 by the syringe 10 and discharging it to the drain (not shown).
  • the cleaning operation method is defined by the type of solvent used in each of the cleaning operation before sample injection and the cleaning operation after sample injection, and the number of inhalations and discharges by the syringe 10.
  • the recommended method presentation unit 18 is a function for assisting the user when setting a method such as a cleaning operation.
  • the recommended method presentation unit 18 presents a plurality of request items to the user when setting the method, and presents the recommended method to the user according to the request item selected by the user from among those request items. It is configured as follows.
  • FIG. 3 shows an example of a request item list displayed when setting a cleaning operation method. The user can arbitrarily select a desired request item from the displayed request item list. In FIG. 3, two requirement items are selected, but only one requirement item can be selected, or three or more requirement items can be selected.
  • the recommended method is a method built in advance so that the effect of each requirement item is achieved.
  • the arithmetic control device 8 is provided with a storage area for storing information about recommended methods corresponding to each of the request items, and when the user selects a desired request item, the operation control device 8 is provided with a storage area.
  • the recommended method presenting unit 18 reads out the recommended method that matches the selected request item and presents it to the user by displaying it on the display 22.
  • the user can edit the parameters related to the method by referring to the displayed recommended method, and the parameters of the displayed recommended method can be applied as they are.
  • FIG. 4 shows an example of a recommended method prepared in advance corresponding to the selected request item.
  • the user selects only the requirement item "reduction of carryover"
  • four kinds of solvents A to D are used in the cleaning operation, and C, in the cleaning operation before sample injection.
  • a recommended method constructed to use the solvent of D and the solvents of A and B in the cleaning operation after sample injection is presented.
  • a solvent contained in a vial different from the solvent used in the cleaning after the sample injection is used in the cleaning before the sample injection, so that the cleaning effect in the syringe 10 is high and the sample is carried. The effect of less overrun is obtained.
  • a recommended method constructed to use the solvent contained in a common vial for the cleaning operation before sample injection and the cleaning operation after sample injection is presented. Will be done.
  • a recommended method corresponding to the case where a plurality of required items are selected at the same time is also prepared in advance.
  • the solvent arrangement setting unit 20 of the arithmetic control device 8 is a function for setting the breakdown of the solvent arrangement on the turret 4.
  • the breakdown of the solvents arranged on the turret 4 that is, the number of solvents arranged and their types can be arbitrarily set by the user. If four vials can be placed in the solvent placement location 14 on the turret 4, four types of solvents can be set to be placed in the solvent placement location 14, or multiple solvents of the same type can be placed. It can also be set to. For example, when a cleaning operation method using two kinds of solvents A and B is set, the user sets to arrange two vials containing solvent A and two vials containing solvent B.
  • the user can also set to arrange a plurality of vials containing the same solvent. It is not necessary to arrange the vials in all of the solvent arrangement locations 14, and when the number of analyzes is small, it is possible to set not to arrange the vials in a part of the solvent arrangement locations 14.
  • the solvent arrangement setting unit 20 may automatically set the arrangement of the solvent on the turret 4 suitable for the method set by the method setting unit 16.
  • the arithmetic control device 8 is provided with a storage area for storing information regarding the arrangement of the solvent on the turret 4 corresponding to each of the methods that can be set, and the method is set by the method setting unit 16.
  • the placement of the solvent on the turret 4 is set to correspond to the set method, and information about the number of solvents to be placed at the solvent placement location 14 and their types is displayed on the display 22.
  • the user only needs to place the solvent at the solvent placement location 14 on the turret 4 according to the information displayed on the display 22, and the user himself is suitable for the method. It is not necessary to consider the arrangement of the solvent.
  • the method setting unit 16 displays the method editing screen, and the recommended method presenting unit 18 displays a plurality of request items (step 101).
  • the recommended method presenting unit 18 presents the recommended method corresponding to the selected request item to the user by displaying it on the display 22 (step 103).
  • the method setting unit 16 sets the method based on the information ( Step 104). After that, the user sets the arrangement of the solvent on the turret 4 according to the set method, or the method setting unit 16 automatically sets the arrangement of the solvent on the turret 4 based on the set method (step). 105).
  • One embodiment of the automatic sample injection device is an automatic sample injection device configured to inject a sample into an analyzer by a sampling mechanism that inhales and dispenses a solvent.
  • a method setting unit configured to set a method of a predetermined operation using a solvent based on a solvent placement location where a plurality of solvents contained in the vial are placed, and information input by the user, and the above.
  • the solvent placement setting unit for setting the number of solvents placed in the solvent placement location and their types and the sampling mechanism are controlled so that the predetermined operation is executed by the method set by the method setting unit. It is equipped with a configured control unit.
  • a plurality of request items are presented to the user, and a recommended method corresponding to the selected request item is presented to the user. It has a method presentation section. According to such an aspect, the user can refer to the know-how about the method possessed by the manufacturer, and it becomes easy to construct the method for obtaining the effect desired by the user.
  • the solvent placement setting unit automatically sets the number of solvents and their types to be placed in the solvent placement location based on the method set by the method setting unit. It is configured as follows. Such an embodiment simplifies the setting of the solvent arrangement suitable for the set method. This second aspect can be combined with the first aspect.
  • the predetermined operation may be a cleaning operation of the sampling mechanism before and after the injection operation.
  • the analyzer may be a gas chromatograph.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
PCT/JP2020/046721 2020-05-25 2020-12-15 自動試料注入装置 Ceased WO2021240853A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US17/926,303 US12313608B2 (en) 2020-05-25 2020-12-15 Automatic sample injection device
CN202080100541.5A CN115516307B (zh) 2020-05-25 2020-12-15 试样自动注入装置
JP2022527488A JP7452643B2 (ja) 2020-05-25 2020-12-15 自動試料注入装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020090659 2020-05-25
JP2020-090659 2020-05-25

Publications (1)

Publication Number Publication Date
WO2021240853A1 true WO2021240853A1 (ja) 2021-12-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2020/046721 Ceased WO2021240853A1 (ja) 2020-05-25 2020-12-15 自動試料注入装置

Country Status (4)

Country Link
US (1) US12313608B2 (https=)
JP (1) JP7452643B2 (https=)
CN (1) CN115516307B (https=)
WO (1) WO2021240853A1 (https=)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000097947A (ja) * 1998-09-28 2000-04-07 Shimadzu Corp 自動合成装置
JP2008020242A (ja) * 2006-07-11 2008-01-31 Shimadzu Corp オートサンプラ制御プログラム作成支援システム及び作成支援プログラム
WO2013099660A1 (ja) * 2011-12-26 2013-07-04 株式会社日立ハイテクノロジーズ 自動分析装置及び試料分注プローブ洗浄方法
JP2018109520A (ja) * 2016-12-28 2018-07-12 シスメックス株式会社 分析方法および分析装置
JP2020056725A (ja) * 2018-10-03 2020-04-09 株式会社島津製作所 試料注入装置および試料注入システム

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0810797Y2 (ja) * 1990-07-25 1996-03-29 株式会社島津製作所 ソルベントフラッシュオートサンプラ
JPH06102262A (ja) * 1992-09-18 1994-04-15 Hitachi Ltd ガスクロマトグラフ用試料注入装置
KR100581019B1 (ko) * 2003-11-28 2006-05-17 주식회사 휴텍스 시료의 자동 전처리장치
JP2012042253A (ja) * 2010-08-16 2012-03-01 Shimadzu Corp クロマトグラフ用試料注入装置
JP2012177586A (ja) * 2011-02-25 2012-09-13 Shimadzu Corp シリンジチェック部材及びそれを用いたクロマトグラフ用試料注入装置
JP2015135240A (ja) 2014-01-16 2015-07-27 株式会社島津製作所 自動分析装置用制御装置
US10379087B2 (en) * 2016-08-29 2019-08-13 Shimadzu Corporation Sample injector for chromatography
US10823714B2 (en) 2016-12-29 2020-11-03 Thermo Finnigan Llc Simplified source control interface
CN113383237B (zh) * 2018-09-20 2025-02-07 沃特世科技爱尔兰有限公司 用于生成并执行分析方法的技术

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000097947A (ja) * 1998-09-28 2000-04-07 Shimadzu Corp 自動合成装置
JP2008020242A (ja) * 2006-07-11 2008-01-31 Shimadzu Corp オートサンプラ制御プログラム作成支援システム及び作成支援プログラム
WO2013099660A1 (ja) * 2011-12-26 2013-07-04 株式会社日立ハイテクノロジーズ 自動分析装置及び試料分注プローブ洗浄方法
JP2018109520A (ja) * 2016-12-28 2018-07-12 シスメックス株式会社 分析方法および分析装置
JP2020056725A (ja) * 2018-10-03 2020-04-09 株式会社島津製作所 試料注入装置および試料注入システム

Also Published As

Publication number Publication date
US20230280315A1 (en) 2023-09-07
CN115516307A (zh) 2022-12-23
US12313608B2 (en) 2025-05-27
JP7452643B2 (ja) 2024-03-19
JPWO2021240853A1 (https=) 2021-12-02
CN115516307B (zh) 2024-09-13

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