WO2021169026A1

WO2021169026A1 - Traditional chinese medicine composition for preventing epidemics, and preparation method therefor and use thereof

Info

Publication number: WO2021169026A1
Application number: PCT/CN2020/087608
Authority: WO
Inventors: 奚肇庆; 束雅春; 刘志辉; 马朝群; 汪悦; 史锁芳; 乔飞; 吴磊; 吴旭彤
Original assignee: 江苏省中医院
Priority date: 2020-02-24
Filing date: 2020-04-28
Publication date: 2021-09-02
Also published as: CN111214566A

Abstract

Disclosed are a traditional Chinese medicine composition for preventing epidemics, and a preparation method therefor and the use of the traditional Chinese medicine composition in the preparation of a drug for preventing novel coronavirus (SARS-CoV-2) infections, preventing SARS-CoV-2 infectious pneumonia, treating SARS-CoV-2 infectious pneumonia at the convalescent stage, and preventing viral influenza epidemics. The traditional Chinese medicine composition comprises 6-30 parts of Astragali radix, 6-30 parts of Codonopsis radix, 5-18 parts of bran-fried Atractylodis macrocephalae rhizoma, 6-15 parts of Poria, 3-30 parts of Perillae folium, 3-15 parts of Saposhnikoviae radix, 3-20 parts of Citri reticulatae pericarpium, 2-15 parts of Jujubae fructus, and 2-9 parts of Glycyrrhizae radix.

Description

Epidemic prevention Chinese medicine composition and its preparation method and application

Technical field

The invention relates to an anti-epidemic traditional Chinese medicine composition and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compound prescriptions.

Background technique

The new coronavirus (2019-nCoV) is officially named SARS-CoV-2 by the International Committee for Classification of Viruses. The NCP caused by it is a Class B infectious disease in my country and is included in the management of Class A infectious diseases. The route of transmission is non-body fluid transmission, including respiratory droplets, close contact, aerosol, digestive tract and other transmission routes. The virus is highly infectious and has a high risk of severe illness. There are reports of infections throughout the country. The National Health Commission has issued the "New Coronavirus Infection Pneumonia Treatment Plan (Trial Version 5) and the "New Coronavirus Infection Pneumonia Prevention and Control Plan (Third Edition)", and there is no satisfactory treatment plan.

Isolation is the main method for the control of susceptible populations in major epidemics. In the current SARS-CoV-2 epidemic, the number of infected cases is huge. In the process of treating NCP, medical staff in medical institutions have basic protective equipment, but the quantity of materials is insufficient, and the quality of protection may be reduced; there are many other such as field workers, nurses, and cleaners. , Security personnel and other non-medical personnel who participated in and maintained the smooth progress of the rescue work, due to lack of medical knowledge and protection concepts, are also at risk of infection, and they are all high-risk groups of SARS-CoV-2 infection. Due to the urgency and severity of the epidemic, medical power and diagnosis and treatment guidelines are more inclined to diagnosed and severely ill patients. There are still a large number of suspected patients who cannot obtain adequate medical services in time to be diagnosed. Such patients will be There is a potential risk of the spread of the virus in the surrounding personnel.

Summary of the invention

Objective of the invention: In view of the above technical problems, the present invention provides an anti-epidemic Chinese medicine composition and its preparation method and application. The traditional Chinese medicine composition of the present invention can better serve the prevention, control and treatment of the new crown pneumonia epidemic, effectively control and reduce the infection rate of healthy people, delay the progress of the disease after infection, and reduce the economic burden of patients at the same time, creating good economic and social benefits for the society.

Technical solution: In order to achieve the above-mentioned purpose of the invention, the technical solution adopted by the present invention is as follows:

An anti-epidemic Chinese medicine composition, which comprises the following raw materials in parts by weight:

Astragalus 6-30 parts, Codonopsis 6-30 parts, Bran-fried Atractylodes 5-18 parts,

6-15 parts of Poria, 3-30 parts of Perilla Leaf, 3-15 parts of Parsnip,

3-20 servings of tangerine peel, 2-15 servings of jujube, 2-9 servings of licorice.

As a preference:

The anti-epidemic Chinese medicine composition includes the following raw materials in parts by weight:

10-30 parts of Astragalus, 6-15 parts of Codonopsis, 6-15 parts of Atractylodes macrocephala with bran,

6-15 parts of Poria, 3-15 parts of Perilla Leaf, 3-12 parts of Parsnip,

3-10 parts of dried tangerine peel, 4-12 parts of jujube, 2-9 parts of licorice.

Alternatively, the anti-epidemic Chinese medicine composition includes the following raw materials in parts by weight:

Astragalus 12-30 parts, Codonopsis 7-12 parts, Bran-fried Atractylodes 9-12 parts,

9-12 parts of Poria, 3-10 parts of Perilla Leaf, 3-9 parts of Parsnip,

3-8 servings of tangerine peel, 6-10 servings of jujube, 2-6 servings of licorice.

The present invention also provides a preparation method of the anti-epidemic Chinese medicine composition, which includes mixing the raw materials, adding 5-30 times pure water for extraction, the extraction times are 2 to 3 times, and each extraction time is 30-120 min.

As a preference:

The extracted extract can be used after alcohol purification treatment, or used directly without alcohol purification treatment.

The extracted liquid after extraction can be made into liquid preparations, or can be made into extracts, granules, capsules or pills with or without conventional excipients.

The present invention finally provides the application of the anti-epidemic traditional Chinese medicine composition in the preparation of medicines for the prevention of SARS-CoV-2 infection by the novel coronavirus.

And, the application of the anti-epidemic Chinese medicinal composition in the preparation of a medicine for preventing the novel coronavirus SARS-CoV-2 infectious pneumonia.

In addition, it also relates to the application of the anti-epidemic Chinese medicinal composition in the preparation of a new type of coronavirus SARS-CoV-2 infectious pneumonia in the recovery period.

Finally, the present invention provides the application of the anti-epidemic Chinese medicine composition in the preparation of medicines for the prevention of influenza.

Traditional Chinese medicine has a long history of diagnosing and treating febrile diseases. "Shuowen" says that "everyone who suffers from the epidemic is sickened by the people", pointing out the transmission characteristics of the disease, such as corvee, and each household is easy to get infected. Therefore, Wu Jutong’s "Diagnosis of Febrile Diseases" ："Patients with febrile disease are severely prevalent, and they are often filthy. Every family is like this, if the service dictates it." How to achieve early prevention will be a powerful supplement to the use of individual, family, and regional isolation methods. The "Huang Di Nei Jing" stated that "righteousness is inside, evil cannot be done", "the spirit is guarded, and the disease is safe", both of which put forward the basic treatment principles for the early prevention of diseases. One is to regulate one's own righteousness, so as not to feel the external evil, even if the external evil is felt, it will not cause the disease.

Qian Huang’s "Treatise to the Source of Febrile Diseases" said: "The feeling of exogenous evils is difficult to know after receiving the root, but it can be distinguished by the hair." Existing research data and clinical experience show that the NCP caused by SARS-CoV-2 The main pathological factors include "dampness, cold, heat, turbidity, deficiency", etc. Some doctors included them in the categories of "dampness and warmth disease", "cold and dampness disease", "dampness poisonous disease", and "spring temperature". After the diagnosis and treatment of more than 100 patients, TCM experts believed that the disease was located in the lungs and spleen, dampness trapped the spleen and blocked the lungs, and the Qi mechanism was ascending and descending. They concluded that the basic pathogenesis of severe pneumonia is "dampness, poison, stasis, and closure". . "Theory of febrile disease" stated that "the evil of the epidemic comes from the mouth and nose" and "the evil comes from the mouth and nose." Pu Fuzhou pointed out in detail in the "Research Report on Acute Infectious Diseases of the Motherland Medicine" "The pathogenic agent is transmitted into the human body through the nose of the respiratory tract and the mouth of the digestive tract." The applicant also observed in clinical practice in fever clinics that at the beginning of the infection, patients often have potential pathogenesis characteristics such as weak lung guard and spleen deficiency and dampness. "Warm the evil, first attack the lungs", the lung guard is not solid, and it is one of the internal causes of infection and disease caused by the epidemic virus including SARS-CoV-2. The solid guardian table is an important aspect of preventing this disease; (Damp turbidity) Evil enters from the mouth and nose, the spleen and stomach are deficient in the middle Jiao, the qi is not smooth, the stagnation is accumulated, the evil is attached, and it is easy to accumulate and become bad. Therefore, adjusting the middle Jiao is to prevent this disease. Another important aspect.

Astragalus is derived from the dried roots of legumes Astragalus membranaceus (Fisch.) Bge.var.monghlicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. It has the functions of replenishing qi and raising yang, consolidating the surface and antiperspirant, diuresis and swelling, nourishing body fluid, nourishing blood, supporting toxins and purging pus, astringing sores and regenerating muscles. Used for qi deficiency and fatigue, lack of food, loose stools, subsidence of qi, chronic diarrhea, prolapse of the anus, bleeding and uterine bleeding, superficial deficiency and spontaneous sweating, qi deficiency and edema, internal heat and thirst, blood deficiency and chlorosis, hemiplegia, arthralgia, numbness, ulcerative ulcers, incurable ulcers, chronic ulcers Not grabbing. Astragalus contains complex chemical components, including polysaccharides and saponins, including total astragalus saponins, soya saponins I, astragalus saponins VIII and flavonoids, in addition to a variety of amino acids and trace elements. Astragalus has a wide range of uses. It can be used for the symptoms of spleen and lung qi deficiency or depression of the middle qi, deficiency and spontaneous perspiration caused by deficiency of qi and blood, carbuncle not ulcerated or ulcerated for a long time caused by insufficient qi and blood, and edema, oliguria and numbness of the limbs caused by qi deficiency and blood stagnation. , Arthralgia, qi deficiency and body fluid deficiency syndromes. The pharmacological effects of Astragalus are as follows: (1) It has a regulatory effect on the immune system: it has obvious protective effects on the myocardium of ischemia-hypoxia, ischemia-reperfusion injury, virus infection and drug poisoning; (2) It has two-way effect on blood pressure. Regulation; (3) Lowering blood sugar and reducing diabetes complications: ①Astragalus polysaccharides may reduce the excessive endoplasmic reticulum stress in diabetes by reducing the expression of p-PERK, thereby increasing insulin sensitivity; ②Astragalus can also promote Body metabolism, reduce the activity of aldose reductase, and reduce the accumulation of sorbitol; (4) Astragalus can play an active role in glomerular diseases by regulating protein metabolism disorders in glomerular diseases, increasing plasma albumin levels and reducing urine protein. Function; (5) It has the function of expanding blood vessels, reducing regional vascular resistance, protecting vascular endothelial cells, improving microcirculation and having a good effect of promoting angiogenesis.

Codonopsis is derived from the dried roots of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or Codonopsis tangshen Oliv. It can invigorate the spleen and lungs, nourish blood and promote fluid. It is used for the effects of spleen and lung qi deficiency, lack of food and fatigue, cough and asthma, lack of qi and blood, chlorosis, palpitations, shortness of breath, body wounds and thirst, internal heat to quench thirst. The main effective ingredients are Codonopsis saponins and Codonopsis pilosula polysaccharides. Modern research shows that Codonopsis can directly act on the pituitary gland on the endocrine system, enhance the immune function and anti-stress effects on the immune system; adjust gastrointestinal motility and anti-ulcer effects on the digestive system; have strong heart and anti-ulcer effects on the circulatory system. Shock, blood pressure regulation, anti-myocardial ischemia and inhibition of platelet aggregation, and enhancement of hematopoietic function; sedative, hypnotic, and anti-convulsant effects on the nervous system; anti-anoxia and anti-fatigue effects on the sports system; antibacterial on the respiratory system Anti-inflammatory effect; can affect the reproductive ability of the reproductive system.

Atractylodes is derived from the dry rhizomes of Atractylodes macrocephala Koidz. It has the functions of invigorating the spleen and replenishing qi, drying dampness and diuresis, antiperspirant, and anti-fetus. It is used for spleen deficiency, lack of food, abdominal distension, diarrhea, phlegm, palpitations, edema, spontaneous sweating, and fetal movement. Including volatile oil, Atractylodes polysaccharides, Atractylodes lactones and other chemical components. It has significant effects on the human digestive tract, nervous system, uterine smooth muscle, etc., and can effectively regulate human immune function.

The windbreak is derived from the dried roots of Saposhnikovia divaricata (Turcz.) Schischk. It has the effects of dispelling wind, relieving the skin, eliminating dampness, relieving pain, and relieving spasm. It is used for colds, headaches, rheumatic arthralgia, rubella itching, and tetanus. The main chemical components are chromones, coumarins, organic acids, polysaccharides, polyacetylenes, sterols, etc. Modern research shows that it has antipyretic, analgesic, anti-inflammatory, antibacterial, antitumor, anticonvulsant and other pharmacological effects.

Poria cocos is derived from the dried sclerotia of Poria cocos (Schw.) Wolf, the fungus Poria cocos (Schw.) Wolf. It has the functions of distilling water and dampness, strengthening the spleen and calming the heart. Used for edema, oliguria, dizziness, spleen deficiency, lack of food, loose stools, diarrhea, restlessness, palpitations, and insomnia. Tuckahoe mainly contains two compounds, triterpenoids and polysaccharides; it also contains steroids, choline, amino acids, histidine, volatile oil and trace elements represented by potassium salts. Modern studies have shown that the pharmacological effects of Poria cocos are diuretic, hepatoprotective, immune and gastrointestinal functions, and sedation, etc.

Chenpi is derived from the dried and mature peels of Citrus reticulata Blanco and its cultivated varieties. It has the functions of regulating qi and invigorating the spleen, drying dampness and resolving phlegm. It is used for full abdominal distension, vomiting and diarrhea with less food, coughing and more sputum. It mainly contains volatile oil, flavonoids, alkaloids, inositol and other ingredients. The main pharmacological effects of tangerine peel are as follows: (1) The effect on the digestive system: ① The effect on the smooth muscle of the gastrointestinal tract. ②The impact on digestive enzymes. ③ Cholestatic effect; (2) Effect on cardiovascular system: ① Cardiotonic effect. ②The effect on blood pressure and blood vessels; (3) Antioxidant effect; (4) Antibacterial effect; (5) Anti-asthmatic effect; (6) Anti-tumor effect; (7) Effect on immune system; (8) Anti-allergic effect.

Jujube is derived from the dry mature fruit of Ziziphus jujuba Mill., a plant of the Rhamnus family. It has the effects of nourishing the middle energy and replenishing qi, nourishing blood and anti-fetus. Used for spleen deficiency, lack of food, loose stools due to fatigue, and irritable women. The main chemical components include triterpenoids, saponins, alkaloids, flavonoids, glycosides, nucleosides, sugars, proteins, amino acids, vitamins, amides, organic acids, steroids and other chemical components. Jujube has multiple pharmacological activities and health care effects. It is mainly manifested in the effect of increasing cAMP in white blood cells, anti-allergic reaction, inhibitory effect on nerves, protective effect on liver, enhancing muscle strength, anti-cancer, anti-mutation and anti-lipid effect. Oxidation and so on.

Perilla leaves are derived from the dried leaves (or with tender branches) of Perilla frutescens (L.) Britt. It has the functions of relieving the appearance and dispelling cold, promoting qi and stomach. Used for colds, coughing, nausea, pregnancy vomiting, fish and crab poisoning. The pharmacological effects of perilla leaves are mainly manifested as: (1) antibacterial and antiviral (2) hemostatic effects: ① sedation and analgesia; (3) antioxidant effect; (4) anti-tumor effect.

Licorice is derived from the dried roots and rhizomes of the legume Glycyrrhiza uralensis Fisch. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. in the leguminous family. It has the functions of invigorating the spleen and qi, detoxifying heat, eliminating phlegm and relieving cough, relieving emergency and relieving pain, and reconciling various medicines. For spleen and stomach weakness, fatigue, palpitations, shortness of breath, coughing and excessive sputum, abdominal and limbs contractures, acute pain, carbuncle swelling and sore, to relieve drug toxicity and potency. The main chemical components are licorice. The main types of chemical components are glycyrrhetinic acid, licorice polysaccharides, glycyrrhiza flavonoids, glycyrrhizic acid, licorice chalcone A, glycyrrhizin and so on. Modern studies believe that the pharmacological effects of glycyrrhetinic acid have anti-inflammatory, adrenal cortex hormone-like effects, effects on myocardial ischemia, anti-cancer and anti-tumor effects; licorice flavone has anti-tumor, anti-free radical and anti-aging effects; licorice polysaccharides have Antibacterial effect, regulating body immunity, antiviral effect, and preventing and curing osteoarthritis; Glycyrrhizic acid has anti-fibrosis and immunoregulatory effects; Licorice Chalcone A has anti-inflammatory, antimalarial, antiparasitic and antibacterial effects; licorice Cyclamate has anti-allergic, anti-tumor, anti-inflammatory, and immune-regulating effects.

Based on this, the formula for replenishing qi and solidifying the surface is formed. In the prescription, Astragalus, Atractylodes, Atractylodes, Astragalus, Atractylodes and Atractylodes The three anti-wind medicines are taken from Yupingfeng San. They are combined with Su Ye and Tangerine Peel to relieve wind and qi. It is aromatic to avoid filth as auxiliary, red dates, licorice and stomach smoothness. It relieves the stagnation of scorching and detoxification, so that there is no external evil. Attached. The compatibility of various medicines can play a good preventive effect.

Technical effect: Starting from the theory of Chinese medicine, the present invention provides an anti-epidemic Chinese medicine composition. It is confirmed by clinical observations that it can effectively prevent the new coronavirus SARS-CoV-2 infection and the new coronary pneumonia caused by it, and is effective for the recovery of new coronary pneumonia. The effective treatment is remarkable; in addition, the anti-epidemic Chinese medicinal composition of the present invention can also effectively prevent epidemic virus influenza.

Detailed ways

The technical solutions of the present invention will be further described in detail below through specific embodiments.

Example 1

An anti-epidemic compound combination medicine comprising the following components in parts by weight: 20 parts of astragalus, 10 parts of Codonopsis, 12 parts of bran-fried atractylodes, 10 parts of Poria, 6 parts of perilla leaves, 6 parts of Fangfeng, 6 parts of dried tangerine peel, 6 servings of jujube and 3 servings of licorice. A total of nine medicines.

Weigh the above nine medicines in parts by weight, add 10 times of water, soak for 60min, decoct twice, 60min each time, filter, combine the filtrate, concentrate under reduced pressure to a relative density of about 1.15, straight tube high-speed centrifuge Centrifugation (speed: 16000r/min, flow: 4～6L/min). After centrifugation, add purified water to an appropriate amount of the liquid medicine, stir it evenly, dispense, and sterilize with steam for 45 minutes to obtain its liquid preparation (mixture).

Example 2

An anti-epidemic compound drug combination comprising the following components in parts by weight: 15 parts of Astragalus, 7 parts of Codonopsis, 10 parts of bran-fried Atractylodes, 10 parts of Poria, 6 parts of perilla leaves, 3 parts of Fangfeng, 6 parts of dried tangerine peel, 7 servings of jujube and 2 servings of licorice. A total of nine medicines.

Add 8 times the amount of water to the above pieces of water, soak for 30 minutes, decoct for 40 minutes, and filter; add 8 times the amount of water for the second time, decoct for 40 minutes, and filter. The above-mentioned filtrate was combined, concentrated under reduced pressure to a relative density of about 1.20 (60°C), and centrifuged in a straight tube high-speed centrifuge (rotation speed: 16000 r/min, flow rate: 4-6 L/min). Take an appropriate amount of dextrin and place it in a fluidized bed. Set the inlet air temperature to 100°C. When the material temperature rises to 70°C, start to enter the liquid. The inlet speed is controlled at 80～150r/min, and the atomization pressure is 0.2MPa outside. Within 0.15MPa. After spraying, drying was continued at 70°C for 1 hour to make a total of 1000 g.

Example 3

An anti-epidemic compound combination medicine, comprising the following components in parts by weight: 20 parts of astragalus, 10 parts of Codonopsis, 12 parts of bran-fried Atractylodes, 12 parts of Poria, 9 parts of perilla leaves, 6 parts of Fangfeng, 6 parts of dried tangerine peel, 10 parts of jujube and 3 parts of licorice. A total of nine medicines.

Weigh the above twelve medicines in parts by weight, add 15 times the amount of water to soak for 45 minutes, decoct 2 times, 1 hour each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of about 1.12 (measured at 60°C) Extract the extract, add ethanol to the alcohol content of 65% alcohol precipitation, stand for 24h, take the supernatant, recover the ethanol until there is no alcohol taste and continue to concentrate to a relative density of about 1.30 (measured at 60°C), add appropriate amount of starch, dry, Crush and encapsulate to obtain capsules.

Example 4

An anti-epidemic compound combination medicine comprising the following components in parts by weight: 15 parts by weight of Astragalus, 9 parts by Codonopsis, 9 parts by bran-fried Atractylodes, 9 parts by Poria, 3 parts by perilla leaves, 3 parts by fangfeng, 3 parts by tangerine peel, 6 parts of jujube and 6 parts of licorice. A total of nine medicines.

Weigh the above twelve medicines in parts by weight, add 10 times the amount of water to soak for 45 minutes, decoc 2 times, 60 minutes each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.10 (measured at 60°C). Paste, add ethanol to 70% alcohol content, let it stand for 24h, take the supernatant, recover the ethanol under reduced pressure until it has no alcohol taste and continue to concentrate to a relative density of about 1.35 (measured at 60°C), add an appropriate amount of starch, and mix Homogenize, dry, pulverize, add appropriate amount of binder to make soft material, make pellets, and vacuum dry to obtain pellets.

Example 5

An anti-epidemic compound combination medicine, comprising the following components in parts by weight: 30 parts of Astragalus, 12 parts of Codonopsis, 10 parts of bran-fried Atractylodes, 10 parts of Poria, 6 parts of perilla leaves, 9 parts of Fangfeng, 5 parts of dried tangerine peel, 9 parts of jujube and 3 parts of licorice. A total of nine medicines.

Weigh the above twelve medicines in parts by weight, add 10 times the amount of water, soak for 60min, decoct 2 times, 45min each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of about 1.25 (measured at 60℃) The extract is added with appropriate amount of starch, dried, pulverized, and packed to obtain the extract.

Example 6

An anti-epidemic compound drug combination comprising the following components in parts by weight: 12 parts of Astragalus, 12 parts of Poria, 10 parts of Codonopsis, 10 parts of Bran-fried Atractylodes, 10 parts of Perilla Leaf, 10 parts of Jujube, 8 parts of Fangfeng, There are 8 parts of tangerine peel and 4 parts of licorice, a total of nine medicines.

Weigh the above twelve medicines in parts by weight, add 15 times the amount of water to soak for 60 minutes, decoct 2 times, 60 minutes each time, filter, combine the filtrate, concentrate to twice a day, and take it as a decoction.

Clinical Observation:

1. Clinical data: selected from the outpatient and out-of-hospital consultations of Professor Xi Zhaoqing of Jiangsu Provincial Hospital of Traditional Chinese Medicine from September 2017 to February 2020. For sub-health, middle-aged and elderly people, people who have repeated colds, and close contacts and susceptible people of new coronavirus pneumonia, a total of 58 people have been diagnosed with lung and spleen deficiency or spleen deficiency and dampness syndrome.

2. Diagnostic criteria: refer to the "Influenza diagnosis and treatment criteria and treatment guidelines (2011 edition)", "Traditional Chinese medicine physique classification and determination (2009 edition)", "Chinese medicine new drug clinical research guidelines" and "new coronavirus pneumonia diagnosis and treatment plan" .

3. Treatment method: The treatment group (adults) take this prescription when the damp toxins in winter and spring are excessive or when the seasons change, with 7 days as a course of treatment, and 2 courses of treatment in a row. The specific prescriptions: 12 parts of Astragalus, 12 parts of Poria, 10 parts of Codonopsis, 10 parts of Atractylodes macrocephala with bran, 10 parts of perilla leaves, 10 parts of jujube, 8 parts of Fangfeng, 8 parts of dried tangerine peel, 4 parts of licorice. Decoction one dose a day, take orally twice in the morning and evening. The dose for children is halved, and pregnant women should be used with caution.

Observe the changes in the number of annual cold episodes and the physique score of deficiency of Qi before and after treatment.

4. Efficacy evaluation criteria:

(1) The number of cold episodes after treatment is less than before treatment;

(2) After treatment, the symptoms of Qi-deficiency are alleviated, and the TCM Qi-deficiency constitution score is reduced by ≥30%

TCM Qi Deficiency Constitution Score Form

Note: ¹⁾ : Calculate the total score when the score is ×3, ²⁾ calculate the total score when the score is ×2; ³⁾ calculate the total score when the score is ×1

5. Treatment results:

After treatment, the number of colds in the patient's year was significantly reduced, and the score of Qi deficiency symptoms was reduced by ≥30%, and the differences were statistically significant (P<0.05). See Tables 1 and 2 for details.

Table 1 Comparison of the number of colds in patients before and after treatment [times, M (range)]

Table 2 Comparison of scores of patients with Qi deficiency symptoms before and after treatment [score, M (range)]

Classic case:

Use case 1: Jia Moumou, female, 39 years old. When the season changes, it is easy to catch a cold. Symptoms include nasal congestion, runny nose, phlegm obstruction, occasional cough, usually sweating, conscious fatigue, poor appetite, difficulty falling asleep, easy awakening and nightmarishness, taking the amount of Less, loose stools. Time is Bailu. After taking this prescription for 2 courses, I have not caught a cold again in recent visits, fatigue and spontaneous perspiration have alleviated, and my napkins have increased.

Use case 2: Qin, female, 25 years old. Normal work pressure is relatively high, diet is not regular, easy to catch a cold after fatigue, low blood pressure, chills, dizziness, dry stool, one line for three or four days, irritable personality, delayed menstruation or one line in February. After taking this prescription, it was quite good. In the past year, I only caught a cold once. I felt chills and dizziness also eased. I had a menstrual period and had soft stools.

Use case 3: Li Moumou, male, 13 years old. In the spring and autumn season, it is easy to catch a cold, sore throat, phlegm, vomiting, white or yellow sticky phlegm, nasal congestion, daily stools, dry knots, grinding teeth during sleep, thin body, flat stomach, abdominal pain in case of wind, only food and cold, night Sounds good. After taking this prescription, the frequency of colds has been significantly reduced, the weight has increased, the face is ruddy, and the appetite is still adjusted.

Use case 4: Pan XX, female, 52 years old. Repeatedly susceptible in winter and spring, nasal congestion, sore throat, dizziness and dizziness, sweating easily when moving, usually mentally weak and weak, short of breath and lazy speech, self-professed inability to handle housework, lack of sleep at night, and difficulty falling asleep. After taking this prescription in early spring, the spirits are quite good, the face is ruddy, and I have not caught a cold this winter, and I can also adjust the sleep soundness.

Use Example 5: Yang Moumou, female, 63 years old, chills and wind, usually easy to catch a cold, easy to cough after catching a cold, nasal muddy runny nose, nasal congestion, pharyngeal itching prolonged and unhealed, sleep well at night, easy to sweat when moving. After taking this prescription for 2 courses, I feel refreshed and can't cough. Since autumn and winter, colds have been prevalent and have not contracted illnesses again.

Use case 6: Wang Moumou, male, 45 years old. During a business trip to Wuhan around the winter solstice, she was usually weak and often lingering after feeling the evil. At the end of Jihai, I learned that the new crown was raging, all day long, vigilant, thinking and worrying, shortness of breath and spontaneous sweating, fatigue, lack of breathing, loose stools, loose stools, two or three days a day. After taking this prescription for 2 courses, she felt short of breath, spontaneous sweating, and fatigue, and she was refreshed and she did not suffer from illnesses.

Use case 7: Fang Mou, female, 92 years old. He was diagnosed with new coronary pneumonia for 12 days and was treated in isolation at Nanjing Public Health Medical Center. After treatment, cough and sputum can not be noticed, but feel tired, eat less, abdominal distension, loose stools, tired limbs, complexion, more dreams and easy to wake up. Add this formula to invigorate the spleen and nourish the qi, and add a little yang-protective product. After 2 courses of treatment, the symptoms will be improved, the face will be bright, the spirit will be better, the appetite will be better, and the two stools will be adjusted. The 4 re-examinations were all negative for the viral nucleic acid, and he was discharged from the hospital for recuperation. In addition to the preventive effect before the disease, this prescription can also be used in the later stage of the treatment of new coronary pneumonia to help the righteous qi and eliminate the evil.

Claims

An anti-epidemic Chinese medicine composition, characterized in that it comprises the following raw materials in parts by weight:

6-30 parts of Astragalus, 6-30 parts of Codonopsis, 5-18 parts of Atractylodes macrocephala with bran,

6-15 parts of Poria, 3-30 parts of Perilla Leaf, 3-15 parts of Parsnip,

3-20 servings of tangerine peel, 2-15 servings of jujube, 2-9 servings of licorice.
The anti-epidemic Chinese medicine composition according to claim 1, characterized in that it comprises the following raw materials in parts by weight:

10-30 parts of Astragalus, 6-15 parts of Codonopsis, 6-15 parts of Atractylodes macrocephala with bran,

6-15 parts of Poria, 3-15 parts of Perilla Leaf, 3-12 parts of Parsnip,

3-10 parts of dried tangerine peel, 4-12 parts of jujube, 2-9 parts of licorice.
The anti-epidemic Chinese medicine composition according to claim 1, characterized in that it comprises the following raw materials in parts by weight:

Astragalus 12-30 parts, Codonopsis 7-12 parts, Bran-fried Atractylodes 9-12 parts,

9-12 parts of Poria, 3-10 parts of Perilla Leaf, 3-9 parts of Parsnip,

3-8 servings of tangerine peel, 6-10 servings of jujube, 2-6 servings of licorice.
The preparation method of the anti-epidemic Chinese medicine composition according to any one of claims 1-3, characterized in that it comprises mixing the raw materials, adding 5 to 30 times pure water for extraction, and the number of extractions is 2 to 3 times, each The extraction time is 30-120min.
The preparation method of the anti-epidemic Chinese medicine composition according to claim 4, characterized in that the extract after extraction can be used after alcohol purification treatment, or used directly without alcohol purification treatment.
The preparation method of the anti-epidemic Chinese medicine composition according to claim 4, characterized in that the extracted extract can be made into a liquid preparation, or with or without conventional excipients, into an extract, granule, Capsules or pills.
The use of the anti-epidemic Chinese medicine composition of any one of claims 1 to 3 in the preparation of a medicine for preventing SARS-CoV-2 infection by the new coronavirus.
The use of the anti-epidemic Chinese medicinal composition of any one of claims 1 to 3 in the preparation of a medicine for preventing SARS-CoV-2 infectious pneumonia caused by the novel coronavirus.
Application of the anti-epidemic Chinese medicinal composition of any one of claims 1 to 3 in the preparation of a new type of coronavirus SARS-CoV-2 infectious pneumonia convalescent treatment drug.
The use of the anti-epidemic traditional Chinese medicine composition of any one of claims 1 to 3 in the preparation of a medicine for the prevention of epidemic virus influenza.