WO2021153004A1 - 電解質分析装置 - Google Patents

電解質分析装置 Download PDF

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Publication number
WO2021153004A1
WO2021153004A1 PCT/JP2020/045114 JP2020045114W WO2021153004A1 WO 2021153004 A1 WO2021153004 A1 WO 2021153004A1 JP 2020045114 W JP2020045114 W JP 2020045114W WO 2021153004 A1 WO2021153004 A1 WO 2021153004A1
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WO
WIPO (PCT)
Prior art keywords
reagent
pure water
sample
temperature
electrolyte analyzer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2020/045114
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English (en)
French (fr)
Japanese (ja)
Inventor
孝宏 熊谷
拓士 宮川
友一 岩瀬
遇哲 山本
鉄士 川原
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Hitachi High Tech Corp
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Hitachi High Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi High Tech Corp filed Critical Hitachi High Tech Corp
Priority to US17/792,453 priority Critical patent/US20230032886A1/en
Priority to EP20916870.7A priority patent/EP4099006B1/en
Priority to JP2021574495A priority patent/JP7492540B2/ja
Priority to CN202080093006.1A priority patent/CN115004020B/zh
Publication of WO2021153004A1 publication Critical patent/WO2021153004A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4166—Systems measuring a particular property of an electrolyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus

Definitions

  • the present invention relates to an electrolyte analyzer.
  • the electrolyte analyzer is an apparatus that analyzes electrolyte components such as sodium (Na), potassium (K), and chloride (Cl) in biological samples such as serum and urine.
  • electrolyte components such as sodium (Na), potassium (K), and chloride (Cl)
  • an analysis method used in an electrolyte analyzer for example, an ion-selective electrode method for measuring an electrolyte concentration in a sample by measuring a potential difference between an ion-selective electrode (ISE: Ion Selective Electrode) and a comparative electrode that generates a reference potential. (ISE method) is known.
  • Patent Document 1 describes a sample suction mechanism having a dilution tank for diluting and accommodating a sample, a sample suction nozzle for sucking the diluted sample contained in the dilution tank, and the above.
  • An electrolyte measuring unit that measures the electrolyte concentration of the sample sucked by the sample suction mechanism, an outer tube that surrounds the vicinity of the sample suction port of the sample suction nozzle, and a constant temperature water supply mechanism that circulates constant temperature water through the outer tube.
  • An electrolyte analyzer comprising the above is disclosed.
  • an ion-sensitive membrane that causes a potential difference in response to the ion component is attached to the ion-selective electrode, and the potential that fluctuates depending on the electrolyte concentration in the sample is measured. Further, in order to keep the reference potential constant, the comparison electrode is brought into contact with a solution called a comparison electrode solution. Then, when deriving the electrolyte concentration, conversion to the electrolyte concentration is performed using the potential difference between the ion-selective electrode and the comparison electrode and the calibration curve obtained from the calibration.
  • the relationship between the potential difference and the concentration used in the ISE method changes depending on the temperature. Therefore, if the temperature of the measurement system changes between the time of calibration and the time of measuring the concentration of the biological sample, the obtained potential difference cannot be properly converted to the electrolyte concentration, and an error may occur in the measurement result. There was sex. In particular, when the measurement reagent is switched or the device is started up, the temperature of the measurement reagent to be introduced tends to change, so that it is difficult to carry out appropriate measurement.
  • the present invention has been made in view of the above, and an object of the present invention is to provide an electrolyte analyzer capable of controlling the temperature of a reagent with a simpler configuration.
  • the present application includes a plurality of means for solving the above problems.
  • the result of measuring a reagent having a predetermined ion concentration with an ion selection electrode and the result of measuring a sample with an ion selection electrode are included.
  • it is an electrolyte analyzer that measures the concentration of specific ions in the sample, and the reagent stock solution with a concentration higher than the predetermined ion concentration is diluted and reduced with pure water to obtain a reagent with a predetermined ion concentration.
  • the reagent generation unit is provided with a reagent generation unit to be produced, and the absolute value of the temperature difference between the reagent obtained by the dilution reduction and the pure water is the temperature between the reagent obtained by the dilution reduction and the reagent stock solution. It is assumed that the reagent is produced so as to be smaller than the absolute value of the difference.
  • the temperature of the reagent can be controlled with a simpler configuration.
  • an electrolyte analyzer that dilutes a concentrated reagent (sometimes referred to as a reagent stock solution or a concentrated internal standard solution) and pure water in a dilution reduction section and discharges the concentrated reagent into a dilution tank will be described as an example.
  • a concentrated reagent sometimes referred to as a reagent stock solution or a concentrated internal standard solution
  • the present invention is not limited to this, and the present invention can be applied to, for example, an electrolyte analyzer that discharges a concentrating reagent and pure water into a dilution tank to dilute them.
  • an electrolyte analyzer used for measurement alone will be described as an example, but the present invention is not limited to this, and for example, an automatic biochemical analyzer, an automatic immunoanalyzer, a mass spectrometer and coagulation.
  • the present invention can also be applied to an electrolyte analyzer mounted on an automatic analyzer such as an analyzer, a composite system thereof, or an automatic analysis system to which these are applied.
  • specimen is a general term for analysis targets collected from the living body of a patient, and examples thereof include blood and urine.
  • analysis target that has undergone a predetermined pretreatment on these is also included in the "sample”.
  • FIG. 1 is a diagram schematically showing the overall configuration of the electrolyte analyzer according to the present embodiment.
  • the electrolyte analyzer 100 is roughly composed of a sample dispensing unit 101, an analysis unit 102, a reagent unit 103, and a mechanism unit 104.
  • the sample dispensing unit 101 has a sample dispensing mechanism 13, a transport unit (not shown), and a sample container 14.
  • the sample to be measured is placed in the sample container 14 and transported to the vicinity of the sample dispensing mechanism 13 by the transport unit.
  • the sample dispensing mechanism 13 sucks the sample held in the sample container 14 and discharges it into the dilution tank 10 to dispense the sample and draw it into the electrolyte analyzer 100.
  • the analysis unit 102 includes a dilution tank 10, a sipper nozzle 12, a diluent nozzle 18, an internal standard solution nozzle 19, a waste liquid suction nozzle 20, an ion selection electrode (ISE) 1, a comparison electrode 2, a pinch valve 17, a voltmeter 25, and an amplifier 26. , And a computer 27.
  • the sample discharged to the diluting tank 10 by dispensing by the sample dispensing unit 101 is diluted and stirred with the diluting liquid discharged from the diluting liquid nozzle 18 to the diluting tank 10.
  • Diluting tank 10 The sample diluted and stirred (diluted sample) is sucked by the shipper nozzle 12 and sent to the analysis unit 102, and the waste liquid remaining in the dilution tank 10 is sucked by the waste liquid suction nozzle 20 and discharged to the waste liquid tank. Will be done.
  • the comparative electrode liquid stored in the comparative electrode liquid bottle 5 is sent to the comparative electrode 2 by operating the sipper syringe 9 with the pinch valve 17 closed.
  • the pinch valve 17 By opening the pinch valve 17 in this state, the diluted sample solution sent to the flow path of the ion selection electrode 1 and the comparison electrode solution sent to the flow path of the comparison electrode 2 come into contact with each other to select ions.
  • the electrode 1 and the comparison electrode 2 are electrically conductive.
  • the computer 27 controls the overall operation of the electrolyte analyzer 100, and opens and closes each electromagnetic valve 16 provided in the sample dispensing unit 101, the analysis unit 102, the reagent unit 103, and the mechanism unit 104, and a syringe.
  • the liquid feeding operation liquid feeding amount
  • the potential difference generated between the ion selection electrode 1 and the comparison electrode 2 and the calibration curve obtained by the calibration performed in advance are obtained. Based on this, the concentration of electrolyte in the sample is calculated.
  • the ion-selective electrode 1 has an electromotive force that changes according to the concentration of specific ions (for example, sodium ion (Na +), potassium ion (K +), chlor ion (Cl-), etc.) in the sample.
  • An ion-sensitive film is attached, and the ion-selective electrode 1 outputs an electromotive force corresponding to each corresponding ion concentration in the sample.
  • the computer 27 acquires an electromotive force between the ion selection electrode 1 and the comparison electrode 2 via the voltmeter 25 and the amplifier 26, calculates the ion concentration in the sample from the acquired electromotive force, and displays a device (not shown). It is displayed on the screen or stored in the storage device.
  • the computer 27 discharges the internal standard solution adjusted to a constant concentration from the internal standard solution nozzle 19 into the dilution tank 10 between the sample measurement and the next sample measurement, and performs the measurement in the same manner as the sample. Then, the measurement result is used to correct the potential fluctuation due to a temperature change or the like, that is, the measurement result of the sample is corrected.
  • the reagent section 103 supplies reagents used for measurement and cleaning, and includes a concentrated internal standard solution bottle 3, a diluent bottle 4, a comparative electrode solution bottle 5, a degassing mechanism 6, a filter 15, and a dilution reduction section 24. Have.
  • the concentrated internal standard solution bottle 3 containing the concentrated internal standard solution (concentrating reagent) and the diluent bottle 4 containing the diluent are connected to the internal standard solution nozzle 19 and the diluent nozzle 18 by a flow path via a filter 15, respectively.
  • the internal standard liquid nozzle 19 and the diluent nozzle 18 are installed in a shape in which the tip is introduced into the dilution tank 10.
  • the comparative electrode liquid bottle 5 containing the captured electrode liquid is connected to the comparative electrode 2 by a flow path via the filter 15.
  • the concentrated internal standard solution contained in the concentrated internal standard solution bottle 3 is a concentrated internal standard solution to a known concentration, and is diluted and reduced to a predetermined concentration with a diluted solution to be used for measurement. Is generated.
  • a dilution reduction unit 24 is provided on the flow path from the concentrated internal standard liquid bottle 3 to the internal standard liquid nozzle 19, and the pure water production apparatus 21 is connected by the flow path.
  • the concentrated internal standard solution is diluted and reduced with pure water at a predetermined magnification.
  • the pure water referred to here may be water that does not contain impurities in a certain amount or more, or water that has been deionized.
  • a degassing mechanism is provided in the flow path between the pure water production apparatus 21 and the dilution reduction unit 24, the flow path between the diluent bottle 4 and the dilution tank 10, and the flow path between the comparison electrode solution bottle 5 and the comparison electrode 2. 6 is connected, and the degassed solution is discharged into the dilution tank 10.
  • the dilution reduction unit 24 described above it is desirable, but not limited to, the dilution reduction unit 24 described above to be provided in the flow path between the concentrated internal standard solution bottle 3 and the dilution tank 10.
  • a pure water nozzle for supplying pure water may be provided in the dilution tank 10, and the concentrated internal standard solution may be diluted and reduced using pure water in the dilution tank 10.
  • the mechanical unit 104 has an internal standard liquid syringe 7, a diluent syringe 8, a shipper syringe 9, a solenoid valve 16, and the like, and is responsible for each operation such as liquid feeding.
  • the concentrated internal standard solution and pure water are introduced into the dilution reduction section 24 at a constant ratio by the operation of the internal standard solution syringe 7 and the solenoid valve 16.
  • the concentrated internal standard solution is diluted with pure water and adjusted to a predetermined concentration.
  • the liquid temperature of the concentrated internal standard liquid in the concentrated internal standard liquid bottle 3 gradually approaches room temperature with the passage of time from the installation.
  • the temperature of the liquid in the concentrated internal standard liquid bottle 3 immediately after installation is close to the temperature in the storage state.
  • the minimum storage temperature is set to about 15 ° C
  • the guaranteed use temperature and supply water temperature of the electrolyte analyzer 100 are generally set to about 30 ° C. Therefore, the concentrated internal standard solution and the pure water used for dilution are generally set.
  • a maximum temperature difference of 15 ° C. or more may occur between water. Therefore, the temperature of the internal standard solution produced by dilution with pure water changes as the temperature of the solution in the bottle changes.
  • the measurement is appropriately performed, that is, it is easily estimated from the constant temperature (more specifically, the temperature of the environment in which the electrolyte analyzer 100 is installed) regardless of the temperature of the concentrated internal standard solution.
  • the dilution ratio in the dilution / reduction unit 24 is controlled in order to generate an internal standard solution (a temperature at which the temperature is possible and the error on the measurement is within a predetermined allowable range) by dilution reduction with pure water.
  • the pure water used in the electrolyte analyzer 100 which is estimated to have a temperature as close as possible to the environment in which the electrolyte analyzer 100 is installed, is used to dilute the concentrated internal standard solution. Make a reduction. That is, in the present embodiment in which the concentrated internal standard solution is diluted and reduced using such pure water, at least the ratio (volume ratio) of the concentrated internal standard solution and the supplied pure water is set to the concentrated internal standard solution.
  • Pure water Dilute with a ratio larger than 1: 1 (however, concentrated internal standard liquid amount ⁇ pure water amount).
  • the concentrated internal standard solution is diluted with pure water at a volume ratio such that the difference between the temperature of the internal standard solution produced by dilution and the temperature of pure water (diluted solution) is 1 ° C. or less.
  • the minimum temperature (storage temperature, etc.) estimated in the concentrated internal standard solution is 15 ° C.
  • the difference between the temperature of the internal standard solution generated by the dilution and the temperature of pure water (diluted solution) is set to 1 ° C or less. be able to. Since the temperature of pure water is estimated to be a constant temperature close to the environmental temperature in which the electrolyte analyzer 100 is installed, the change in the temperature of the internal standard solution generated by dilution for each measurement is the concentrated internal standard solution. The temperature will be 1 ° C or lower regardless of the temperature of the liquid in the bottle 3. As a result, it is possible to perform measurement using the internal standard solution having an appropriate temperature without depending on the temperature of the concentrated internal standard solution in the three concentrated internal standard solution bottles installed in the electrolyte analyzer 100, which is appropriate. Measurement becomes possible.
  • FIG. 2 is a diagram showing the relationship between the temperatures of the concentrated internal standard solution, pure water, and the internal standard solution diluted and reduced with pure water.
  • the absolute value of the temperature difference TD2 between the internal standard solution (temperature T3) and pure water (temperature T2) obtained by dilution reduction becomes the concentrated internal standard solution (temperature T1) and the internal standard.
  • the internal standard liquid is generated so that the temperature difference from the liquid (temperature T3) is smaller than the absolute value of TD3.
  • the pure water produced by the pure water production apparatus 21 is temporarily stored in the supply water tank 22, passes through the degassing portion by the pump 23 as appropriate, and then supplied into the apparatus.
  • the temperature of the pure water supplied to the apparatus becomes equal to the room temperature, and the temperature of the entire electrolyte analyzer 100 including the measurement system is controlled based on the room temperature. It becomes easy to do.
  • the pure water supply system is not limited to the above-mentioned body shape.
  • the supply water tank 22 and the degassing unit may be omitted, or the pure water supply may be controlled by using a syringe without providing the pump 23.
  • the pure water supplied into the apparatus in this way is sent to the dilution reduction section 24 by opening and closing the solenoid valve and the operation of the internal standard solution syringe 7, and is mixed with the concentrated internal standard solution in the dilution reduction section 24 to have a predetermined concentration. Produces an internal standard solution.
  • the generated internal standard solution and diluent are sent to the dilution tank 10 by the operation of the internal standard solution syringe 7, the diluent syringe 8, and the solenoid valve.
  • the temperature of the diluent is controlled within a certain range through the preheat 11.
  • the reagent unit 103 and the mechanism unit 104 constitute a reagent generation unit that produces a reagent having a predetermined ion concentration by diluting and reducing a reagent stock solution having a concentration higher than a predetermined ion concentration with pure water.
  • the sample dispensing unit 101, the dilution tank 10 of the analysis unit 102, the reagent unit 103, and the mechanism unit 104 constitute a sample dilution unit that dilutes the sample to be analyzed with a diluent to generate a diluted sample.
  • the sample collected in the sample container 14 is transported to the sample dispensing section 101 by a transfer mechanism (not shown).
  • the sample is dispensed from the sample container 14 by the sample dispensing mechanism 13 in the sample dispensing section 101 and discharged to the dilution tank 10.
  • the diluent is discharged from the diluent bottle 4 by the operation of the diluent syringe 8 and the solenoid valve 16 from the dilution nozzle to dilute the sample.
  • the degassing mechanism 6 installed in the diluent channel performs the degassing treatment.
  • the diluted sample is sucked into the ion selection electrode 1 by the operation of the shipper syringe 9 and the solenoid valve 16.
  • the comparison electrode solution is sent from the comparison electrode solution bottle 5 into the comparison electrode by the pinch valve 17 and the sipper syringe 9, and the diluting solution and the comparison electrode solution come into contact with each other, whereby the ion selection electrode 1 and the comparison electrode 2 are brought into contact with each other. Is electrically conductive.
  • the electromotive force corresponding to the concentration of the diluted solution generated at the ion-selective electrode is measured using the voltmeter 25 and the amplifier 26 with the comparison electrode 2 as a reference.
  • the concentrated internal standard solution is diluted with pure water to a predetermined concentration, and the generated internal standard solution is discharged into the dilution tank 10 by the internal standard solution syringe 7, and the inside is operated in the same manner as the sample measurement. Measure the standard solution. A calculation is performed by a computer 27 from the measured potential difference and the result obtained by the calibration performed in advance, and the electrolyte concentration in the sample is calculated.
  • the relationship between the potential difference and the concentration used in the ISE method changes depending on the temperature. Therefore, if the temperature of the measurement system changes between the time of calibration and the time of measuring the concentration of the biological sample, the obtained potential difference cannot be properly converted to the electrolyte concentration, and an error may occur in the measurement result. There was sex. In particular, when the measurement reagent is switched or the device is started up, the temperature of the measurement reagent to be introduced tends to change, so that it is difficult to carry out appropriate measurement.
  • the electrolyte analyzer 100 measures the concentration of specific ions in the sample based on the result of measuring the reagent having the ion concentration predetermined by the ion selection electrode 1, and is in advance.
  • a reagent generation unit (for example, reagent unit 103 and mechanism unit 104) that produces a reagent having a predetermined ion concentration by diluting and reducing a reagent stock solution (concentrated internal standard solution) having a concentration higher than a predetermined ion concentration with pure water.
  • the reagent generator is provided so that the absolute value of the temperature difference between the reagent obtained by dilution reduction and pure water is smaller than the absolute value of the temperature difference between the reagent obtained by dilution reduction and the reagent stock solution. Since it is configured to generate the reagent, the temperature of the reagent can be controlled with a simpler configuration.
  • a diluted sample is produced by diluting the sample with pure water instead of the diluent.
  • FIG. 3 is a diagram schematically showing the overall configuration of the electrolyte analyzer according to the present embodiment.
  • the same members as those in the first embodiment are designated by the same reference numerals, and the description thereof will be omitted.
  • the supply flow path supplied to the apparatus using the pump 23 is the internal standard liquid syringe 7.
  • the supply configuration to the internal standard solution syringe 7 and the supply configuration to the diluent syringe 8 may be independently provided.
  • the absolute value of the temperature difference between the diluted sample and pure water is smaller than the absolute value of the temperature difference between the diluted sample and the sample, and the temperature change of the diluted sample is 1 ° C. or less. Generated.
  • the preheat 11 for temperature adjustment can be omitted.
  • the same effect can be obtained by providing the dilution-reducing section 24 in the dilution water flow path and using a concentrated diluent having a concentration corresponding to the dilution ratio.
  • the pure water is provided with a circulation channel for circulating pure water in the electrolyte analyzer, and the diluted internal standard solution (concentrated reagent) is diluted with the pure water introduced from the circulation channel. It is configured to do.
  • FIG. 4 is a diagram schematically showing the overall configuration of the electrolyte analyzer according to the present embodiment.
  • the same members as those in the second embodiment are designated by the same reference numerals, and the description thereof will be omitted.
  • the electrolyte analyzer 100 is provided on the flow path from the pump 23 to the internal standard solution syringe 7 and the diluent syringe 8, and the pure water delivered from the pump 23 is circulated in the electrolyte analyzer 100. It has a circulation flow path 29, a pump 30 for circulating pure water in the pure water circulation flow path 29, and an electromagnetic valve 28 provided on the flow path from the pump 23 to the pure water circulation flow path 29.
  • the pure water used for diluting the concentrated internal standard solution is introduced from the pure water circulation flow path 29.
  • the pure water generated by the pure water production device 21 is held in the supply water tank 22, and is supplied to the pure water circulation flow path 29 after passing through the degassing device by the pump 30.
  • the pure water circulation flow path 29 efficiently circulates pure water in the path by the pump 30.
  • the temperature of the pure water in the pure water circulation flow path 29 is made uniform, and even if the temperature of the pure water supplied from the pure water production apparatus 21 changes, the temperature change as a system can be reduced. ..
  • Considering that the temperature of pure water is controlled to be constant depending on the room temperature by circulating in the pure water circulation flow path 29, it is possible to omit the supply water tank 22.
  • the amount of pure water used for diluting the concentrated internal standard solution is newly added to the pure water circulation flow path 29 by opening and closing the solenoid valve 28 provided at the introduction portion of the pure water circulation flow path 29 and operating the pump 30. Be supplied.
  • This embodiment is provided with a temperature control device for controlling the temperature of pure water in the pure water circulation flow path according to the third embodiment.
  • FIG. 5 is a diagram schematically showing the overall configuration of the electrolyte analyzer according to the present embodiment.
  • the same members as those in the third embodiment are designated by the same reference numerals, and the description thereof will be omitted.
  • the electrolyte analyzer 100 has a temperature control device 31 that constantly controls the temperature of pure water circulating in the pure water circulation flow path 29.
  • the temperature control device 31 may, for example, monitor the temperature of the circulating water with a thermocouple and control the output of the heater based on the obtained temperature, and the embodiment thereof is not limited.
  • the temperature of the circulating pure water is controlled to be constant regardless of the room temperature or the temperature of the supply water. That is, the temperature of the internal standard solution generated by diluting the concentrated internal standard solution and the pure water introduced from the pure water circulation flow path 29 is also controlled to be constant regardless of the environmental temperature. This enables stable measurement with high robustness against changes in the environment.
  • the present embodiment is provided with a sterilizer for sterilizing pure water in the pure water circulation flow path according to the third embodiment.
  • FIG. 6 is a diagram schematically showing the overall configuration of the electrolyte analyzer according to the present embodiment.
  • the same members as those in the third embodiment are designated by the same reference numerals, and the description thereof will be omitted.
  • the electrolyte analyzer 100 has a sterilizer 32 that sterilizes the pure water circulating in the pure water circulation flow path 29.
  • the pure water existing in the pure water circulation flow path 29 may cause growth of bacteria and the like when the electrolyte analyzer 100 is in the system OFF state and retention occurs or when circulation is continued for a long period of time. There is. If the properties of pure water change due to the growth of bacteria, the ion concentration of the target sample may not be obtained appropriately. In addition, a film is generated in the flow path, which may cause clogging of the flow path. Therefore, in the present embodiment, a sterilizer 32 is provided in the pure water circulation flow path 29 in order to prevent the influence of the growth of fungi.
  • the sterilizer 32 uses, for example, ultraviolet rays to sterilize pure water in the flow path in a non-contact manner.
  • a sterilizer 32 using a commonly used liquid it is necessary to select the sterilizer 32 based on the ion concentration and the chemical reaction contained in the liquid for sterilization.
  • stable measurement becomes possible even in long-term use.
  • the pure water circulation flow path has an analysis unit 102 that measures reagents with an ion-selective electrode, a dilution tank 10 that dilutes the sample to be measured with pure water, and It is provided so as to pass through the preheat 11 for heating the reagent generated by the reagent generation unit (reagent unit 103 and mechanism unit 104).
  • FIG. 7 is a diagram schematically showing the overall configuration of the electrolyte analyzer according to the present embodiment.
  • the same members as those in the third embodiment are designated by the same reference numerals, and the description thereof will be omitted.
  • the pure water circulation flow path 29 of the electrolyte analyzer 100 passes through the ion selection electrode 1, the dilution tank 10, and the preheat 11 installed in the internal standard solution and the diluent section, and these are passed through at the temperature of the circulating water. It is configured to stay constant. However, it may be configured to pass only a part of them, that is, to keep the temperature of only a part constant. Moreover, you may go through other routes.
  • the pure water circulation flow path 29 is configured so as to keep the entire system related to the measurement constant at the circulating water temperature as in the present embodiment, stable measurement with less temperature change becomes possible. ..
  • the temperature of the internal standard solution produced by using the pure water introduced from the circulating water is substantially equal to the temperature of the pure water used for dilution. Therefore, even when the preheat 11 is provided, it is advantageous in terms of reduction of the space of the region and simplification of the configuration as compared with the system of diluting the concentrating reagent with pure water.
  • the present invention is not limited to the above-described embodiment, and includes various modifications and combinations within a range that does not deviate from the gist thereof. Further, the present invention is not limited to the one including all the configurations described in the above-described embodiment, and includes the one in which a part of the configurations is deleted. Further, each of the above configurations, functions and the like may be realized by designing a part or all of them by, for example, an integrated circuit. Further, each of the above configurations, functions, and the like may be realized by software by the processor interpreting and executing a program that realizes each function.
  • Pure water production equipment 22 ... Supply water tank, 23 ... Appropriate pump, 23 ... Pump, 24 ... Diluting reduction unit, 25 ... Voltage meter, 26 ... amplifier, 27 ... computer, 28 ... electromagnetic valve, 29 ... pure water circulation flow path, 30 ... pump, 31 ... temperature control device, 32 ... sterilizer, 100 ... electrolyte analyzer, 101 ... sample dispensing section, 102 ... Analysis part, 103... Reagent part, 104... Mechanism part

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PCT/JP2020/045114 2020-01-29 2020-12-03 電解質分析装置 Ceased WO2021153004A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US17/792,453 US20230032886A1 (en) 2020-01-29 2020-12-03 Electrolyte analysis apparatus
EP20916870.7A EP4099006B1 (en) 2020-01-29 2020-12-03 Electrolyte analysis apparatus
JP2021574495A JP7492540B2 (ja) 2020-01-29 2020-12-03 電解質分析装置
CN202080093006.1A CN115004020B (zh) 2020-01-29 2020-12-03 电解质分析装置

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JP2020012734 2020-01-29
JP2020-012734 2020-01-29

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EP4411380A4 (en) * 2021-09-30 2025-08-06 Hitachi High Tech Corp AUTOMATIC ANALYZER

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