WO2021118292A3 - 금속-유기 골격체를 포함하는 상처 치유용 조성물 - Google Patents
금속-유기 골격체를 포함하는 상처 치유용 조성물 Download PDFInfo
- Publication number
- WO2021118292A3 WO2021118292A3 PCT/KR2020/018159 KR2020018159W WO2021118292A3 WO 2021118292 A3 WO2021118292 A3 WO 2021118292A3 KR 2020018159 W KR2020018159 W KR 2020018159W WO 2021118292 A3 WO2021118292 A3 WO 2021118292A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- wound
- composition
- organic framework
- wound healing
- healing
- Prior art date
Links
- 239000012621 metal-organic framework Substances 0.000 title abstract 4
- 230000029663 wound healing Effects 0.000 title abstract 3
- 206010052428 Wound Diseases 0.000 abstract 5
- 208000027418 Wounds and injury Diseases 0.000 abstract 5
- 230000000694 effects Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 229920000247 superabsorbent polymer Polymers 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
- A61F13/0209—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings comprising superabsorbent material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/28—Zirconium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/58—Metal complex; Coordination compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
본 발명은 금속-유기 골격체(metal-organic framework, MOF)를 유효성분으로 포함하는 상처 치유용 조성물 및 상기 금속-유기 골격체를 포함하는 친수성 고흡수성 고분자를 포함하는 창상 피복재에 관한 것으로, 상기 조성물 및 창상 피복재는 상처 치유능, 구체적으로 섬유아세포 이동을 촉진시켜 상처를 치유하는 우수한 효과가 있고, 세포 독성에 있어 대조군과 유의미한 차이가 없어 창상 부위에 적용 시 우수한 안전성을 가지며, 시간이 경과함에 따라 육안으로 확인할 수 있을 정도로 높은 창상 회복률을 가지는 우수한 효과가 있다.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022515570A JP7465011B2 (ja) | 2019-12-13 | 2020-12-11 | 金属-有機骨格体を含む傷治癒用組成物 |
CN202080062508.8A CN114364379A (zh) | 2019-12-13 | 2020-12-11 | 含有金属有机框架材料的用于伤口愈合的组合物 |
US17/640,015 US20220323330A1 (en) | 2019-12-13 | 2020-12-11 | Composition for wound healing, containing metal-organic framework |
EP20900141.1A EP4074311A4 (en) | 2019-12-13 | 2020-12-11 | WOUND HEALING COMPOSITION COMPRISING AN ORGANIC METAL FRAMEWORK |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20190167194 | 2019-12-13 | ||
KR10-2019-0167194 | 2019-12-13 | ||
KR1020200172690A KR102457562B1 (ko) | 2019-12-13 | 2020-12-10 | 금속-유기 골격체를 포함하는 상처 치유용 조성물 |
KR10-2020-0172690 | 2020-12-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2021118292A2 WO2021118292A2 (ko) | 2021-06-17 |
WO2021118292A3 true WO2021118292A3 (ko) | 2021-07-29 |
Family
ID=76330201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2020/018159 WO2021118292A2 (ko) | 2019-12-13 | 2020-12-11 | 금속-유기 골격체를 포함하는 상처 치유용 조성물 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220323330A1 (ko) |
EP (1) | EP4074311A4 (ko) |
JP (1) | JP7465011B2 (ko) |
CN (1) | CN114364379A (ko) |
WO (1) | WO2021118292A2 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220109152A (ko) * | 2021-01-28 | 2022-08-04 | 서울대학교병원 | 금속-유기 골격체 및 실리콘 조성물을 포함하는 실리콘 패치 |
CN115192762B (zh) * | 2022-08-15 | 2023-11-28 | 浙江理工大学 | 一种医用复合材料及其制备方法和应用 |
CN115252874B (zh) * | 2022-08-18 | 2023-10-20 | 常州美杰医疗用品有限公司 | 一种可生物降解医用绷带及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100239512A1 (en) * | 2006-08-17 | 2010-09-23 | Russell Edward Morris | Adsorption and release of nitric oxide in metal organic frameworks |
US8771756B2 (en) * | 2009-12-28 | 2014-07-08 | Colorado State University Research Foundation | Biocompatible materials for medical devices |
US20180236122A1 (en) * | 2014-12-20 | 2018-08-23 | Northwestern University | Polymer metal-organic framework composites |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2921661B1 (fr) * | 2007-10-01 | 2013-05-31 | Centre Nat Rech Scient | Solide hybride organique inorganique a surface modifiee. |
KR100998920B1 (ko) | 2008-08-21 | 2010-12-09 | 한밭대학교 산학협력단 | 창상 치유용 피부 외용제 조성물 |
EP3253485B1 (en) | 2015-02-03 | 2021-12-15 | University Court of The University of St Andrews | No containing compositions |
KR101923825B1 (ko) | 2017-08-24 | 2019-02-27 | 국방과학연구소 | 화학작용제 제독제, 이를 이용한 제독방법 및 이를 포함하는 제품 |
KR102000367B1 (ko) | 2017-12-15 | 2019-07-15 | 연세대학교 산학협력단 | Par1 활성 강화제 및 이를 포함하는 상처 치료용 조성물 |
KR20190083593A (ko) | 2018-01-04 | 2019-07-12 | 계명대학교 산학협력단 | 만성상처 전용 창상피복제 및 이를 이용하는 방법 |
CN111440253B (zh) | 2019-01-17 | 2021-08-27 | 中国科学院上海药物研究所 | 立方形环糊精骨架-rgd组合物及其制备方法 |
CN110483802A (zh) * | 2019-09-10 | 2019-11-22 | 南方科技大学 | 一种金属有机框架材料及其制备方法和应用 |
-
2020
- 2020-12-11 WO PCT/KR2020/018159 patent/WO2021118292A2/ko unknown
- 2020-12-11 EP EP20900141.1A patent/EP4074311A4/en active Pending
- 2020-12-11 JP JP2022515570A patent/JP7465011B2/ja active Active
- 2020-12-11 CN CN202080062508.8A patent/CN114364379A/zh active Pending
- 2020-12-11 US US17/640,015 patent/US20220323330A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100239512A1 (en) * | 2006-08-17 | 2010-09-23 | Russell Edward Morris | Adsorption and release of nitric oxide in metal organic frameworks |
US8771756B2 (en) * | 2009-12-28 | 2014-07-08 | Colorado State University Research Foundation | Biocompatible materials for medical devices |
US20180236122A1 (en) * | 2014-12-20 | 2018-08-23 | Northwestern University | Polymer metal-organic framework composites |
Non-Patent Citations (2)
Title |
---|
CHEN ZHIJIE, WANG XINGJIE, ISLAMOGLU TIMUR, FARHA OMAR K.: "Green Synthesis of a Functionalized Zirconium-Based Metal–Organic Framework for Water and Ethanol Adsorption", INORGANICS, vol. 7, no. 5, 56, 26 April 2019 (2019-04-26), pages 1 - 9, XP055830854, DOI: 10.3390/inorganics7050056 * |
GOSWAMI SUBHADIP, RAY DEBMALYA, OTAKE KEN-ICHI, KUNG CHUNG-WEI, GARIBAY SERGIO J., ISLAMOGLU TIMUR, ATILGAN AHMET, CUI YUEXING, CR: "A porous, electrically conductive hexazirconium(IV) metal–organic framework", CHEMICAL SCIENCE, vol. 9, no. 19, 1 January 2018 (2018-01-01), pages 4477 - 4482, XP055830856, ISSN: 2041-6520, DOI: 10.1039/C8SC00961A * |
Also Published As
Publication number | Publication date |
---|---|
WO2021118292A2 (ko) | 2021-06-17 |
EP4074311A4 (en) | 2023-11-01 |
JP7465011B2 (ja) | 2024-04-10 |
CN114364379A (zh) | 2022-04-15 |
EP4074311A2 (en) | 2022-10-19 |
JP2022547185A (ja) | 2022-11-10 |
US20220323330A1 (en) | 2022-10-13 |
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