WO2021085564A1 - 遺伝子銃 - Google Patents

遺伝子銃 Download PDF

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Publication number
WO2021085564A1
WO2021085564A1 PCT/JP2020/040705 JP2020040705W WO2021085564A1 WO 2021085564 A1 WO2021085564 A1 WO 2021085564A1 JP 2020040705 W JP2020040705 W JP 2020040705W WO 2021085564 A1 WO2021085564 A1 WO 2021085564A1
Authority
WO
WIPO (PCT)
Prior art keywords
certain embodiments
accelerator module
detonation
module according
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2020/040705
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
デイヴィッド マイケル フォアマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daicel Corp
Original Assignee
Daicel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daicel Corp filed Critical Daicel Corp
Priority to US17/771,950 priority Critical patent/US20220362473A1/en
Priority to KR1020227017574A priority patent/KR102797112B1/ko
Priority to JP2021553698A priority patent/JP7704684B2/ja
Priority to CN202510308485.9A priority patent/CN120242238A/zh
Priority to EP20882074.6A priority patent/EP4052745A4/en
Priority to CN202080076864.5A priority patent/CN114641328B/zh
Publication of WO2021085564A1 publication Critical patent/WO2021085564A1/ja
Anticipated expiration legal-status Critical
Priority to JP2025108243A priority patent/JP2025129249A/ja
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3007—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules with specially designed jet passages at the injector's distal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • C—CHEMISTRY; METALLURGY
    • C06—EXPLOSIVES; MATCHES
    • C06C—DETONATING OR PRIMING DEVICES; FUSES; CHEMICAL LIGHTERS; PYROPHORIC COMPOSITIONS
    • C06C7/00—Non-electric detonators; Blasting caps; Primers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods

Definitions

  • a particular aspect includes that the second material is a detonating output material.
  • Certain embodiments include the body comprising an opening to the container.
  • the opening is sized and shaped such that when the initiator module is connected to the accelerator module, a portion of the initiator module passes through the opening.
  • Certain embodiments include the plurality of doped metal particles comprising gold.
  • a particular aspect includes that the initiator module is an electric explosive device (EED).
  • EED electric explosive device
  • the fire charge of the initiator module may be, for example, zirconium, potassium perchlorate, or a mixture thereof.
  • the explosive charge is not limited to these, and various explosives that can generate explosive combustion, which is a subsonic wave, by igniting and burning can be used.
  • the fire engine charge according to the present disclosure the fire engine charge used for an initiator used for inflating an airbag for an automobile can be suitably applied.
  • the wall segment 44 does not burst as the detonation wave passes through it, thus maintaining a barrier between the detonation material and the tissue.
  • the wall segment 44 of the body 14 bursts when a plurality of particles 60 are ejected (released) from the ejection tube 58, but due to, for example, the size and shape of the burst, the gene gun 10 Sufficiently dampen the pressure loss from. As a result, the plurality of particles 60 still have an initial velocity greater than the speed of sound before entering the tissue.
  • FIG. 4 is a side view of the accelerator module 12 shown in FIG.
  • the body 14 of the accelerator module 12 comprises a base 16 and a cap 18.
  • the body 14 is manufactured as a single monolithic structure.
  • the main body 14 of the accelerator module 12 is assembled from three or more structures.
  • FIG. 8 is a cross-sectional view through the accelerator module 12 shown in FIG. 4 as viewed along the cut plane 8-8 of FIG. 4, with the initiator 30 and the chambers aligned (aligned) along the axis 28. Both 45 and the injection cylinder 58 are shown.
  • the chamber 45 is part of a container 20 and is located between the initiator 30 and the bottom surface 54 of the container 20.
  • the wall segment 44 separates the chamber 45 from the ejection tube 58.
  • the flame escaping from the casing 32 ignites the material in the chamber 45.
  • the pressure released by the fire charge 34 in the casing 32 destroys the casing 32 and a subsonic deflagration propagates along the shaft 28 in the chamber 45. Ignite the material.
  • a plurality of doped metal particles are put into a cell (preferably a cell in a tissue, and a cell in a state of being present in a human individual (living body) (preferably a cell in a tissue)).
  • a mode excluding cells (preferably cells in a tissue) in a state existing in an individual animal (living body) is also preferable.
  • Ignition of the fireworks device placed in the portable device to generate a subsonic wave, and propagating the subsonic wave along the axis toward the material placed in the portable device.
  • the material is ignited by the subsonic wave to generate a supersonic wave, and the supersonic wave is continuously propagated along the axis toward the wall segment of the portable device.
  • an accelerator module configured to receive the initiator module, 4) a wall segment that separates the detonation output material from the doped metal particles, and 5) an explosion that passes through the wall segment without destroying the wall segment.
  • a roaring (explosion) wave Uses a roaring (explosion) wave, 6) doped metal particles that achieve speeds above sound velocity, and 7) doped metal particles located downstream of the detonation (explosion) wave and / or 8) detonation. And igniting a detonation wave, including. Therefore, protection is not limited to the details of the embodiments described above. Protection is any new or any new combination of features disclosed herein (including the accompanying claims, abstracts, and drawings), or any method or method so disclosed. It extends to any new one or any new combination of steps in the process.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
PCT/JP2020/040705 2019-10-30 2020-10-29 遺伝子銃 Ceased WO2021085564A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US17/771,950 US20220362473A1 (en) 2019-10-30 2020-10-29 Gene gun
KR1020227017574A KR102797112B1 (ko) 2019-10-30 2020-10-29 유전자 총
JP2021553698A JP7704684B2 (ja) 2019-10-30 2020-10-29 遺伝子銃
CN202510308485.9A CN120242238A (zh) 2019-10-30 2020-10-29 基因枪
EP20882074.6A EP4052745A4 (en) 2019-10-30 2020-10-29 Particle bombardment
CN202080076864.5A CN114641328B (zh) 2019-10-30 2020-10-29 基因枪
JP2025108243A JP2025129249A (ja) 2019-10-30 2025-06-26 遺伝子銃

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962928280P 2019-10-30 2019-10-30
US62/928,280 2019-10-30

Publications (1)

Publication Number Publication Date
WO2021085564A1 true WO2021085564A1 (ja) 2021-05-06

Family

ID=75715193

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2020/040705 Ceased WO2021085564A1 (ja) 2019-10-30 2020-10-29 遺伝子銃

Country Status (6)

Country Link
US (1) US20220362473A1 (https=)
EP (1) EP4052745A4 (https=)
JP (2) JP7704684B2 (https=)
KR (1) KR102797112B1 (https=)
CN (2) CN120242238A (https=)
WO (1) WO2021085564A1 (https=)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000502036A (ja) * 1995-12-20 2000-02-22 ニトロ・ノーベル・アクチエボラーグ 雷管のための火工品装薬
JP2001523328A (ja) * 1997-04-09 2001-11-20 ジ・エンサイン−ビツクフオード・カンパニー 緩く充填された点火装薬を含む起爆装置及び集成方法
JP2004236657A (ja) 2003-02-03 2004-08-26 Bioware Technology Co Ltd 低圧ガス加速遺伝子銃
US20100198146A1 (en) * 2009-02-05 2010-08-05 Gopalan Jagadeesh Apparatus and method for delivering biologically-active substances or micro-medical devices to a target
US20170216530A1 (en) * 2014-08-02 2017-08-03 Peter Lell Needle-free injection device comprising a membrane
JP2017535033A (ja) * 2014-10-22 2017-11-24 レル ピーター 火薬式駆動装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462391B (sv) * 1984-08-23 1990-06-18 China Met Imp Exp Shougang Spraengkapsel och initieringselement innehaallande icke-primaerspraengaemne
US5204253A (en) * 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
EP1545593A1 (en) 2002-09-27 2005-06-29 PowderJect Research Limited Nucleic acid coated particles
US20040162517A1 (en) * 2002-12-04 2004-08-19 Otto Furst Needleless hydpodermic injection device with non-electric ignition means
DE10306716A1 (de) * 2003-02-17 2004-09-02 Lell, Peter, Dr.-Ing. Vorrichtung zum Injizieren eines staub-oder pulverförmigen Stoffs in ein Gewebe eines Körpers
EP2959931A1 (de) 2014-06-24 2015-12-30 LTS LOHMANN Therapie-Systeme AG Nadellose Injektionsvorrichtung

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000502036A (ja) * 1995-12-20 2000-02-22 ニトロ・ノーベル・アクチエボラーグ 雷管のための火工品装薬
JP2001523328A (ja) * 1997-04-09 2001-11-20 ジ・エンサイン−ビツクフオード・カンパニー 緩く充填された点火装薬を含む起爆装置及び集成方法
JP2004236657A (ja) 2003-02-03 2004-08-26 Bioware Technology Co Ltd 低圧ガス加速遺伝子銃
US20100198146A1 (en) * 2009-02-05 2010-08-05 Gopalan Jagadeesh Apparatus and method for delivering biologically-active substances or micro-medical devices to a target
US20170216530A1 (en) * 2014-08-02 2017-08-03 Peter Lell Needle-free injection device comprising a membrane
JP2017535033A (ja) * 2014-10-22 2017-11-24 レル ピーター 火薬式駆動装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP4052745A4

Also Published As

Publication number Publication date
EP4052745A1 (en) 2022-09-07
US20220362473A1 (en) 2022-11-17
KR20220092914A (ko) 2022-07-04
CN114641328A (zh) 2022-06-17
EP4052745A4 (en) 2023-11-01
JPWO2021085564A1 (https=) 2021-05-06
JP2025129249A (ja) 2025-09-04
CN114641328B (zh) 2025-04-01
KR102797112B1 (ko) 2025-04-18
CN120242238A (zh) 2025-07-04
JP7704684B2 (ja) 2025-07-08

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