WO2021079688A1 - 分析装置 - Google Patents

分析装置 Download PDF

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Publication number
WO2021079688A1
WO2021079688A1 PCT/JP2020/036558 JP2020036558W WO2021079688A1 WO 2021079688 A1 WO2021079688 A1 WO 2021079688A1 JP 2020036558 W JP2020036558 W JP 2020036558W WO 2021079688 A1 WO2021079688 A1 WO 2021079688A1
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WO
WIPO (PCT)
Prior art keywords
sample
container
analyzer
transport
storage container
Prior art date
Application number
PCT/JP2020/036558
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English (en)
French (fr)
Japanese (ja)
Inventor
研吾 西村
洋平 奥田
Original Assignee
東洋紡株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 東洋紡株式会社 filed Critical 東洋紡株式会社
Priority to JP2021554196A priority Critical patent/JP7283568B2/ja
Publication of WO2021079688A1 publication Critical patent/WO2021079688A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system

Definitions

  • the present disclosure relates to an analyzer, and more specifically, to a mechanism for supplying a sample container of the analyzer.
  • sample analyzer that analyzes the components of a sample.
  • Some sample analyzers mix a sample and a drug in a sample container and image the sample with an imaging device.
  • a plurality of sample containers are previously stored in the storage container inside the device.
  • the sample containers in the storage container are supplied one by one from the storage container toward the test stage at the time of inspection. Since the supply speed of the sample container affects the test speed, a more reliable and high-speed operation sample container supply mechanism is required.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 2008-0967
  • a specimen plate storage cassette having a plurality of specimen plate storage cassettes, a rotating body provided with a plurality of cassette installation portions for installing the specimen plate storage cassette, a driving means for rotating the rotating body, and an upper portion of the cassette.
  • the present disclosure has been made in view of the above background, and an object in a certain aspect is to provide a technique for supplying a sample container toward a test stage at a higher speed.
  • An analyzer includes a storage container for storing a sample container for storing a sample, and a transport mechanism for pushing the sample container from the storage container toward a sample preparation table.
  • the storage container each includes a plurality of areas in which the sample container can be stored, and each of the plurality of areas is directed from the first side surface of the storage container to the second side surface of the storage container opposite to the first side surface.
  • a plurality of transport ports are provided to penetrate.
  • the analyzer further includes a drive unit that moves the storage container in a direction perpendicular to the moving direction of the transport mechanism so that the transport mechanism moves to pass through any of the plurality of transport ports.
  • each of the plurality of areas is stored by stacking a plurality of sample containers.
  • the lowermost sample container among the sample containers stacked in the first region at the extrusion position of the transport mechanism, which is one of a plurality of regions, has a first transport port penetrating the first region. It is stored in a position where it is pushed out by the passing transport mechanism.
  • the storage container is replaceable from the analyzer.
  • the analyzer further comprises a control unit that controls the analyzer.
  • the control unit counts the number of times the sample container is transported by the transport mechanism, and is housed in a second region which is one of a plurality of regions and supplies the sample container to the sample preparation table based on the count. It is detected that the sample container is exhausted, the storage container is moved based on the detection, and the third area adjacent to the second area is moved to the extrusion position of the transport mechanism.
  • control unit counts the number of movements of the storage container and detects the range of the remaining number of sample containers contained in the storage container based on the counting of the number of movements of the storage container.
  • control unit counts the number of times the transport mechanism is pushed out, and detects the remaining number of sample containers contained in the storage container based on the count of the number of times the storage container is moved and the number of times the transport mechanism is pushed out. To do.
  • the area of each of the plurality of transport ports is larger than the area of the surface passing through any of the plurality of transport ports of the sample container.
  • the area of the extruded surface of the transport mechanism is smaller than the area of the surface that passes through any of the plurality of transport ports of the sample container.
  • FIG. 1 is a diagram showing an example of the appearance of the analyzer according to the present embodiment.
  • the analyzer 20 includes an information processing device inside, and an input interface and an output interface that can be connected to an external device.
  • input devices such as mice and keyboards may be connected to the input interface.
  • the analyzer 20 operates according to the instruction from the input device.
  • an output device such as a liquid crystal display may be connected to the output interface. In that case, the analyzer 20 outputs the analysis result of the sample to the output device.
  • the analyzer 20 can be used for the analysis of various samples. Specimens analyzed include urine as an example, cerebrospinal fluid (eg, lumbar spinal fluid) as another example, suboccipital fluid as yet another example, and ventricular fluid as yet another example.
  • the analyzer 20 includes a main body 20A and a transport unit 20B.
  • the main body 20A houses a control unit 210, a sample preparation unit 222, an image pickup device 223, and the like, which will be described later.
  • the transport unit 20B transports a container (Spitz) for accommodating a sample. More specifically, in the analyzer 20, each sample is housed in a container 4.
  • the rack 7 accommodates one or more containers 4.
  • the transport unit 20B includes a groove 250. In the transport unit 20B, one or more containers 4 are transported in a state of being housed in the rack 7.
  • the transport mode of the container 4 described with reference to FIG. 1 is merely an example. In the analyzer 20, the container 4 may be transported alone without being housed in the rack 7.
  • the material of the container 4 is preferably a plastic material (polystyrene, polycarbon, polypropylene, etc.) from the viewpoint that charged ions are unlikely to be generated.
  • Glass which is generally used as a material for the container 4, is usually negatively charged.
  • PLL poly-L-lysine
  • the material of the container 4 may affect the sedimentation rate of the elements (cells and the like) in the sample (sample).
  • the analysis in consideration of the influence can be realized by the calibration.
  • a barcode reader 224 is provided on the main body 20A.
  • a barcode for identifying each sample is attached to each container 4.
  • the analyzer 20 identifies each of the samples to be inspected by reading each barcode of the container 4 with a barcode reader 224.
  • FIG. 2 is a diagram showing an example of the hardware configuration of the analyzer 20 according to the present embodiment.
  • the analyzer 20 includes a control unit 210, a communication unit 221, a sample preparation unit 222, an image pickup device 223, a barcode reader 224, a first drive unit 225, a second drive unit 226, and a third.
  • the drive unit 227, the operation unit 228, the input interface 229, and the output interface 230 are included.
  • the control unit 210 has a CPU (Central Processing Unit) 211 and a storage device 212.
  • CPU Central Processing Unit
  • the CPU 211 executes or refers to various programs and data read into the storage device 212.
  • the CPU 211 may be an embedded CPU, an FPGA (Field-Programmable Gate Array), or a combination thereof.
  • the CPU 211 can execute a program for realizing various functions of the analyzer 20.
  • the CPU 211 identifies the analysis result of the sample by analyzing the captured image.
  • image analysis is formation analysis.
  • the CPU 211 determines whether or not the pre-stored image pattern of the formed component is included in the image of the sample. After that, when the CPU 211 determines that the image of the sample contains the image pattern of the formed portion, the CPU 211 counts the number of the formed portion in the image and outputs the number.
  • the storage device 212 may store any program and data executed or referenced by the CPU 211.
  • the storage device 212 will be described as an example of a storage location for information. That is, the information "stored in the storage device 212" must be stored in the storage device 212 as long as it is stored in a storage device such as the CPU 211 that can be accessed by the processor that executes the process in the present specification. There is no.
  • the storage device 212 includes a RAM (Random Access Memory) and a non-volatile storage device.
  • RAM Random Access Memory
  • DRAM Dynamic Random Access Memory
  • SRAM Static Random Access Memory
  • EPROM Erasable Programmable Read Only Memory
  • EEPROM Electrically Erasable Programmable Read-Only Memory
  • flash memory HDD (Hard Disk Drive), SSD (Solid State Drive), or a combination thereof is a non-volatile memory. It may be used as a device.
  • the communication unit 221 transmits the data from the control unit 210 to another device, and inputs the information from the other device to the control unit 210.
  • a wired LAN (Local Area Network) port, a Wi-Fi (registered trademark) module, or the like may be used as the communication unit 221.
  • the communication unit 221 may send and receive data using a communication protocol such as TCP / IP (Transmission Control Protocol / Internet Protocol) and UDP (User Datagram Protocol).
  • the sample preparation unit 222 prepares a sample necessary for analysis.
  • the sample is prepared, for example, by mixing and stirring the sample in the container 4 and the reagent required for measurement.
  • the image pickup device 223 captures an image of the sample prepared by the sample preparation unit 222.
  • the image pickup apparatus 223 has an automatic focusing mechanism. As a result, the sample prepared by the sample preparation unit 222 is automatically imaged by the image pickup apparatus 223.
  • the image pickup apparatus 223 outputs the captured image to the control unit 210.
  • the barcode reader 224 reads the barcode attached to the container 4 and outputs the read information to the control unit 210.
  • the barcode may be a one-dimensional barcode or a two-dimensional barcode.
  • a non-contact IC reader may be used in place of the barcode reader 224. In that case, the container 4 is provided with a non-contact IC.
  • the imaging device 223 may capture a plurality of images for one sample and output them to the control unit 210.
  • the CPU 211 displays, for each sample, an image including an image pattern (for example, an image pattern of a specific formed portion related to urine) stored in a predetermined storage device 212 among a plurality of images for one sample. It may be stored in the storage device 212 in association with the formed portion.
  • an image pattern for example, an image pattern of a specific formed portion related to urine
  • the first drive unit 225 drives a motor or the like provided in the transport unit 20B (see FIG. 1) to transport the rack 7 (or the container 4).
  • the second drive unit 226 drives the transport mechanism 404, which will be described later.
  • the third drive unit 227 drives a cassette 403 or a pedestal on which the cassette 403, which will be described later, is placed.
  • the first drive unit 225, the second drive unit 226, and the third drive unit 227 may each include both a circuit that controls the motor and a motor.
  • the control unit 210 controls each of these drive units.
  • the operation unit 228 is realized by, for example, a hardware button provided on the main body 20A.
  • the operation unit 228 When the operation unit 228 is operated, the operation unit 228 outputs a signal corresponding to the type of the operated button or the like to the CPU 211.
  • the input interface 229 can be connected to any input device such as a keyboard, mouse or gamepad.
  • a USB (Universal Serial Bus) terminal may be used as the input interface 229.
  • the output interface 230 can be connected to any output device such as a cathode ray tube display, a liquid crystal display or an organic EL (Electro-Luminescence) display.
  • a USB (Universal Serial Bus) terminal a D-sub terminal, a DVI (Digital Visual Interface) terminal, an HDMI (registered trademark) (High-Definition Multimedia Interface) terminal, or the like may be used as the output interface 230.
  • FIG. 3 is a diagram showing an example of a process of analyzing a sample in the analyzer 20.
  • the analysis of the sample mainly includes five steps (steps (i) to (v)) shown in FIG.
  • Step (i) is the preparation of the sample. More specifically, a preparation 70, which is a sample container, is prepared for each sample.
  • the preparation 70 includes a storage portion 71, a recess 72, and a cover glass 73.
  • the cover glass 73 covers the recess 72.
  • step (i) (a part of) a sample is extracted from the container 4 (see FIG. 1) and injected into the storage unit 71, and further, a drug (for example, a staining solution) is injected into the storage unit 71.
  • a drug for example, a staining solution
  • Addition of the drug may be omitted. That is, in step (i), only injection of (a part of) the sample into the storage unit 71 can be performed.
  • the step (ii) is mixing of the sample (sample + drug) prepared in the storage unit 71 and heating (warming).
  • the mixing and heating may be realized by known techniques. By heating, the sample is heated to a preset temperature suitable for analysis. At least one of mixing and heating can be omitted if not needed.
  • the step (iii) is the introduction of the sample in the storage unit 71 into the recess 72. More specifically, the sample in the reservoir 71 is introduced into the recess 72 by, for example, a capillary phenomenon. Stimulation may be applied to the cover glass 73 to facilitate the introduction of the sample.
  • the process (iv) is an imaging of a sample (sample). More specifically, the image pickup apparatus 223 images the sample introduced into the recess 72 from above the cover glass 73. The imaging of the image may be automated by the autofocus function.
  • Step (v) is an analysis of the image captured in step (iv). An example of an analysis involves identifying the content of a given component in a sample.
  • Steps (i) to (iii) are performed by the sample preparation unit 222 of the analyzer 20.
  • the imaging of the image of the sample is performed by the imaging apparatus 223.
  • the image pickup apparatus 223 includes a camera for acquiring an image of a sample.
  • the camera is, for example, a CCD (Charge-Coupled Device) image sensor, a three CCD image sensor, or a CMOS (Complementary Metal-Oxide Semiconductor) image sensor.
  • the area imaged by the camera of the image pickup apparatus 223 depends on the resolution of the camera and / or the magnification of the lens.
  • Step (v) is executed by the control unit 210.
  • FIG. 4 is a diagram showing an example of the internal mechanism of the analyzer 20 as viewed from above.
  • the analyzer 20 includes sensors 401A, 401B, 401C, a cassette 403, a transport mechanism 404, a transport stand 405, an image pickup stand 406, a holding unit 407, a waste container 408, and the like. It is provided with a drug container 409 and a cleaning unit 410.
  • the holding portion 407 includes an outer wall 407A and a fall-out prevention component 407B.
  • the sensors 401A, 401B, and 401C each detect the rack 7 carried to the vicinity of the wall surface of the groove 250.
  • the groove 250 is divided into two compartments (compartment (A) and compartment (B)), and one or more racks 7 are set in the compartment (A).
  • the rack 7 is conveyed one by one from the compartment (A) to the compartment (B) by the first drive unit 225 provided on the wall surface of the groove 250 or the like.
  • the sensors 401A, 401B, and 401C are provided on the wall surface of the groove 250, which is the traveling direction of the rack 7, respectively.
  • the rack 7 may be set in the compartment (B) and transported to the compartment (A).
  • the cassette 403 (storage container) stores the preparation 70 used for sample analysis.
  • the analyzer 20 removes the slide 70 from the cassette 403 for each analysis of the sample.
  • the cassette 403 includes four storage units. Each storage unit is, for example, an area for storing 10 to 100 slides 70, preferably 20 to 70 slides, and 40 slides 70 as an example.
  • the cassette 403 is driven by the third drive unit 227 perpendicularly to the traveling direction of the transport mechanism 404.
  • the preparation 70 in the storage portion located in front of the transport mechanism 404 is pushed out to the transport table 405 (sample preparation table).
  • control unit 210 By counting the number of times the cassette 403 has moved, the control unit 210 detects from which storage unit the preparation 70 is being supplied toward the transfer table 405. In one aspect, the control unit 210 may detect the range of the remaining number of the slides 70 stored in the cassette 403 based on which storage unit the slides 70 are supplied to the transfer table 405.
  • the preparation 70 can be detected as being supplied from, for example, the first storage unit.
  • the preparation 70 can be detected as being supplied from, for example, the fourth storage unit.
  • the remaining number of the preparation 70 in this case is the remaining number "0 to 40" of the preparation 70 of the fourth storage portion. Therefore, the control unit 210 detects that the number of remaining slides 70 is “0 to 40”.
  • the cassette 403 may be provided with various sensors such as an infrared sensor or a switch.
  • the control unit 210 can determine whether or not the remaining number of the slide 70 in the storage unit is 0 based on the detection result of the sensor.
  • the control unit 210 moves the cassette 403 when the remaining number of the preparation 70 of the storage unit at the extrusion position of the transport mechanism 404 is 0.
  • the transport mechanism 404 is a linear motion mechanism, and pushes the slide 70 stored in the storage portion of the cassette 403 to the transport stand 405.
  • the transport mechanism 404 is driven by a second drive unit 226.
  • the preparation 70 prepares a sample on the transport table 405. After that, the transfer mechanism 404 pushes the slide 70 on the transfer table 405 to the image pickup table 406.
  • control unit 210 may count the number of times that the transfer mechanism 404 extrudes the preparation 70 from the storage unit at the extrusion position of the transfer mechanism 404.
  • the control unit 210 can detect the remaining number of the slide 70 stored in the cassette 403 based on the number of times the cassette 403 has moved and the number of times the transfer mechanism 404 has pushed the slide 70 out of the storage unit.
  • the control unit 210 informs the user of the range of the remaining number of the preparation 70 stored in the cassette 403 or the remaining number of the preparation 70 stored in the cassette 403 via the communication unit 221 or the output interface 230. You may notify. With these configurations, the user can replace or replenish the slide 70 before the preparation 70 housed in the cassette 403 runs out.
  • the transport table 405 is a passage through which the preparation 70 is transported.
  • the slide 70 is once arranged in the center of the transport table 405 by the transport mechanism 404.
  • the preparation 70 is prepared on the transfer table 405 and then pushed out to the image pickup table 406 by the transfer mechanism 404.
  • the imaging table 406 is a table for the imaging device 223 to image the sample in the preparation 70.
  • An imaging device 223 is arranged above the imaging table 406.
  • the image pickup apparatus 223 images the sample in the preparation 70 arranged on the image pickup table 406.
  • the holding unit 407 holds the preparation 70 arranged on the imaging table 406 and adjusts the position of the preparation 70.
  • the holding unit 407 is connected to a driving unit (not shown).
  • the driving unit allows the holding unit 407 to move in the direction perpendicular to the imaging direction of the imaging device 223, that is, in the horizontal direction with respect to the imaging table 406. By moving the holding unit 407, the position of the preparation 70 with respect to the image pickup device 223 is also adjusted.
  • the outer wall 407A has an opening, and the preparation 70 is inserted into the outer wall 407A through the opening by the transport mechanism 404.
  • the outer wall 407A surrounds the slide 70 inserted inside from three directions.
  • the fall-out prevention component 407B includes an elastic body such as a spring and closes a part of the opening of the outer wall 407A to prevent the slide 70 inside the outer wall 407A from falling off. Further, the fall-out prevention component 407B is provided with an inclination on a surface facing the traveling direction of the preparation 70. When the transfer mechanism 404 pushes the preparation 70 toward the holding portion 407, the inclined surface of the fall prevention component 407B is pressed against the preparation 70.
  • the fall prevention component 407B moves to a position that does not prevent the preparation 70 from being pushed into the outer wall 407A from the opening.
  • the fall prevention component 407B returns to its original position to prevent the slide 70 in the outer wall 407A from falling out of the outer wall 407A.
  • the prepared slide 70 after imaging is discarded.
  • the holding unit 407 slides from the imaging table 406 to the disposal container 408 by the driving unit.
  • the preparation 70 inside the holding portion 407 falls into the waste container 408.
  • the holding portion 407 returns to the imaging table 406.
  • the drug container 409 contains a drug for preparing a sample by being mixed with the sample (for example, a staining solution for enhancing the visibility of formed components in the sample).
  • a movable sample acquisition unit which will be described later, is provided on the upper part of the transport table 405.
  • the sample acquisition unit acquires the drug from the drug container 409 and puts the drug in the preparation 70 on the transport table 405.
  • the sample acquisition unit acquires a sample from the container 4 to be inspected arranged in the center of the analyzer 20, and puts the sample in the preparation 70 on the transport table 405.
  • the cleaning unit 410 cleans the tip of the sample acquisition unit.
  • the sample acquisition unit cleans the tip of the sample acquisition unit by discharging the cleaning liquid from the inside of the cleaning unit 410.
  • the cleaning unit 410 has a drainage groove for cleaning liquid.
  • FIG. 5 is a diagram showing an example of the operation procedure (1) of the internal mechanism of the analyzer 20.
  • the rack 7 set in the groove 250 is conveyed in the direction of the arrow 501 by the first drive unit 225 provided on the wall surface of the groove 250 or the like.
  • the sensor 401A detects the rack 7, the transport direction of the rack 7 changes, and the rack 7 is transported in the direction of the arrow 502.
  • the Spitz 503 to be analyzed is brought to the center of the analyzer 20.
  • FIG. 6 is a diagram showing an example of the operation procedure (2) of the internal mechanism of the analyzer 20.
  • the transport mechanism 404 is driven in the direction of arrow 601. Then, the transfer mechanism 404 pushes one preparation 70 from any storage portion of the cassette 403 to the center of the transfer table 405. The transfer mechanism 404 pushes the slide 70 to the center of the transfer table 405 and then stops at the same position.
  • the control unit 210 drives the drive unit at the timing when the transfer mechanism 404 returns to the original position. To move the cassette 403 and change the storage unit that supplies the preparation 70.
  • FIG. 7 is a diagram showing an example of the operation procedure (3) of the internal mechanism of the analyzer 20.
  • the sample acquisition unit 701 acquires the drug from the drug container 409, moves in the direction of the arrow 702, and supplies the drug to the preparation 70 on the transport table 405.
  • FIG. 8 is a diagram showing an example of the operation procedure (4) of the internal mechanism of the analyzer 20.
  • the sample acquisition unit 701 moves in the direction of the arrow 801 after supplying the preparation to the preparation 70, inserts the tip of the sample acquisition unit 701 into the cleaning unit 410, and performs the cleaning process.
  • the sample acquisition unit 701 cleans the suction port at the tip of the sample acquisition unit 701 by discharging the cleaning liquid from the inside.
  • FIG. 9 is a diagram showing an example of the operation procedure (5) of the internal mechanism of the analyzer 20.
  • the sample acquisition unit 701 moves in the direction of the arrow 901 after the washing process is completed, and acquires a sample from the Spitz 503 to be analyzed.
  • FIG. 10 is a diagram showing an example of the operation procedure (6) of the internal mechanism of the analyzer 20.
  • the sample acquisition unit 701 moves in the direction of the arrow 1001 after the sample acquisition is completed, and supplies the sample to the preparation 70 on the transport table 405.
  • the processing up to the operation procedure (6) the sample to be imaged described in the steps (i) to (iii) of FIG. 3 is prepared.
  • FIG. 11 is a diagram showing an example of the operation procedure (7) of the internal mechanism of the analyzer 20.
  • the sample acquisition unit 701 moves in the direction of the arrow 1101 after supplying the sample to the preparation 70, inserts the tip of the sample acquisition unit 701 into the cleaning unit 410, and performs the cleaning process.
  • the sample acquisition unit 701 cleans the suction port at the tip of the sample acquisition unit 701 by discharging the cleaning liquid from the inside.
  • two or more slides 70 may be conveyed to the transfer table 405.
  • FIG. 12 is a diagram showing an example of the operation procedure (8) of the internal mechanism of the analyzer 20.
  • the transport mechanism 404 is driven in the direction of arrow 1201. Then, the transfer mechanism 404 inserts the slide 70 on the transfer table 405 into the holding portion 407. When two or more slides 70 are on the transfer table 405, the transfer mechanism 404 pushes all the preparations 70 on the transfer table 405 toward the holding portion 407.
  • the fall-off prevention component 407B may be provided with an inclined surface at a position facing the preparation 70. Further, an inclined surface may be provided at a position where the preparation 70 comes into contact with the fall prevention component 407B.
  • the transport mechanism 404 pushes the two slides 70 toward the holding portion 407
  • the inclined surface of the first slide 70 comes into contact with the inclined surface of the fall prevention part 407B to open the fall prevention part 407B. Push it out of the part. Since the fall-out prevention component 407B moves to the outside of the opening, it does not prevent the first preparation 70 from moving into the outer wall 407A.
  • the fall-out prevention component 407B After the first slide 70 is completely inside the outer wall 407A, the fall-out prevention component 407B returns to its original position and subsequently contacts the inclined surface of the second slide 70 to allow the second slide 70. Prevents 70 from moving into the outer wall 407A.
  • the analyzer 20 is provided with an inclined surface on both the fall prevention component 407B and the preparation 70, so that two preparations 70 can be simultaneously mounted on the imaging table 406 without precisely controlling the extrusion amount of the transport mechanism 404. It is supplied and can prevent the holding portion 407 from being clogged.
  • FIG. 13 is a diagram showing an example of the operation procedure (9) of the internal mechanism of the analyzer 20.
  • the holding unit 407 adjusts the position of the slide 70 with respect to the image pickup device 223 by moving in the biaxial direction (the biaxial direction of the arrow 1301) perpendicular to the image pickup direction of the image pickup device 223.
  • the image pickup apparatus 223 adjusts the focus of the lens of the image pickup apparatus 223 by moving in the vertical direction with respect to the preparation 70.
  • the image pickup apparatus 223 images a sample in the preparation 70 after the adjustment of the position of the preparation 70 and the adjustment of the focus of the lens of the image pickup apparatus 223 are completed.
  • the analyzer 20 can perform the operations of FIGS. 5 to 11 with respect to the subsequent preparation 70.
  • FIG. 14 is a diagram showing an example of the operation procedure (10) of the internal mechanism of the analyzer 20.
  • the holding unit 407 disposes of the preparation 70 by moving to the position of the disposal container 408 (in the direction of the arrow 1401) after the imaging of the sample in the preparation 70 is completed.
  • FIG. 15 is a diagram showing an example of the operation procedure (11) of the internal mechanism of the analyzer 20.
  • the rack 7 is oriented in the direction of the arrows 1501 to 1503 so that the container 4 to be inspected next comes to the center of the analyzer 20. It will be carried.
  • FIG. 16 is an example of an enlarged bird's-eye view of the cassette 403.
  • the cassette 403 includes four storage units 1601A to 1601D as an example.
  • the storage units 1601A to 1601D are collectively referred to, they are referred to as storage units 1601.
  • Each storage unit 1601 is a space partitioned by a wall, and preparations 70 are stacked and stored in each storage unit 1601. As an example, if each storage unit 1601 stores 40 slides 70, the cassette 403 will store a total of 160 slides 70.
  • Conveyance ports 1602A to 1602D are provided near the bottom surface of the surface of the cassette 403.
  • the transport ports 1602A to 1602D are provided so as to be paired with the surface 1603 and the surface 1604 on the back side thereof.
  • transport ports 1602. are referred to as transport ports 1602.
  • the surfaces 1603 and 1604 are side surfaces of the cassette 403, respectively.
  • the transport ports 1602A to 1602D on the surface 1603 and the transport ports 1602A to 1602D on the surface 1604 are connected to each other through the storage portions 1601A to 1601D, respectively.
  • the transport port 1602A on the surface 1603 and the transport port 1602A on the surface 1604 are connected through the storage portion 1601A.
  • the transport mechanism 404 advances from the transport port 1602A on the surface 1604 into the storage portion 1601A, and pushes the slide 70 out from the transport port 1602A on the surface 1603. The details of the pushing operation will be described later.
  • FIG. 17 is a diagram showing an example of the supply mechanism of the preparation 70 in the analyzer 20.
  • the cassette 403 is connected to the third drive unit 227.
  • the control unit 210 controls the third drive unit 227 to move the cassette 403 in the direction perpendicular to the pushing direction of the transport mechanism 404.
  • the cassette 403 may be removable from the analyzer 20. In that case, the user can replace the cassette 403 installed on the base or the like connected to the third drive unit 227 from the take-out port or the like of the housing of the analyzer 20.
  • the remaining number of the preparation 70 of the storage unit 1601A is 0.
  • the control unit 210 controls the third drive unit 227 to move the storage unit 1601B to the extrusion position of the transfer mechanism 404.
  • the control unit 210 controls the third drive unit 227 to move the storage unit 1601C to the extrusion position of the transfer mechanism 404.
  • control unit 210 moves the last storage unit 1601D to the extrusion position of the transfer mechanism 404, the remaining number of the slide 70 stored in the cassette 403 via the communication unit 221 or the output interface 230. You may notify the user that the range, the remaining number of slides 70 stored in the cassette 403, or the slides 70 are about to run out.
  • the control unit 210 enters the cassette 403 via the communication unit 221 or the output interface 230.
  • the user may be notified that the range of the number of slides stored, the number of slides 70 stored in the cassette 403, or the slide 70 is about to run out.
  • FIG. 18 is a side view of the cross section of the cassette 403.
  • the operation of the transport mechanism 404 pushing the slide 70 out of the cassette 403 will be described with reference to FIG.
  • the operation of the transport mechanism 404 pushing the slide 70 out of the storage unit 1601A will be described.
  • the transport mechanism 404 similarly pushes the slide 70 with respect to the other storage portions 1601B to 1601D.
  • a plurality of slides 70 are stacked and stored in the storage unit 1601A.
  • the transport ports 1602 on the surfaces 1603 and 1604 are provided near the bottom of the cassette 403.
  • the extruded surface of the transport mechanism 404 is in the reference position, and the preparation 70 of the storage unit 1601A is not extruded either.
  • the transport mechanism 404 proceeds from the transport port 1602 on the surface 1604 to the inside of the storage portion 1601A.
  • the bottommost preparation 70 in the storage portion 1601A is pushed by the push-out surface of the transport mechanism 404, and is pushed out from the transport port 1602 of the surface 1603.
  • the transport mechanism 404 returns to the original position after completely pushing the bottom preparation 70 in the storage portion 1601A to the outside of the cassette 403.
  • the transport mechanism 404 goes out from the transport port 1602 on the surface 1604
  • the slide 70 stacked in the remaining storage portion 1601A falls to the bottom of the storage portion 1601A due to its own weight. That is, the preparations 70 stacked in the remaining storage portion 1601A fall one by one at the height of the preparation 70.
  • each area of the transport port 1602 may be larger than the area of the surface passing through the transport port 1602 of the preparation 70. Further, the area of the extruded surface of the transport mechanism 404 may be smaller than the area of the surface that passes through the transport port 1602 of the preparation 70.
  • the supply mechanism of the preparation 70 according to the present embodiment sequentially supplies the preparation 70 stacked and stored in the storage unit 1601 in the direction of the transport table 405 by using only the linear motion of the transport mechanism 404. To do. With this configuration, the slide 70 to be transported next falls in front of the transport mechanism 404 due to its own weight when the slide 70 previously transported is completed. Therefore, the analyzer 20 transports the preparation 70 to the transport table. It can be supplied at high speed in the direction of 405. Further, the supply mechanism of the preparation 70 according to the present embodiment has less mechanical operation and does not need to use a member such as an elastic body that easily deteriorates with time. The possibility of operation can be reduced, and the reliability and maintainability are excellent. In addition, since the number of parts required is smaller than that of the conventional one, there is an advantage in terms of manufacturing cost.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
PCT/JP2020/036558 2019-10-24 2020-09-28 分析装置 WO2021079688A1 (ja)

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Citations (3)

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JPH0221951U (enrdf_load_stackoverflow) * 1988-07-28 1990-02-14
JP2017201285A (ja) * 2016-04-28 2017-11-09 シスメックス株式会社 検体塗抹装置

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JPH0734361Y2 (ja) * 1990-06-13 1995-08-02 東亜医用電子株式会社 スライドガラス供給装置
JP2548248Y2 (ja) * 1990-08-21 1997-09-17 アロカ株式会社 試験管立て供給装置
JPH0843405A (ja) * 1994-07-28 1996-02-16 Fuji Photo Film Co Ltd 生化学分析装置
JP2002181834A (ja) 2000-12-13 2002-06-26 Fuji Photo Film Co Ltd 生化学分析用カートリッジ
JP3988399B2 (ja) 2001-03-09 2007-10-10 スズキ株式会社 染色体標本展開装置
JP4043288B2 (ja) 2002-05-27 2008-02-06 株式会社エスアールエル 染色体標本展開装置
JP4358025B2 (ja) 2004-04-30 2009-11-04 シスメックス株式会社 スライドガラス供給装置およびそれを備える標本作製装置
JP4910617B2 (ja) 2006-10-10 2012-04-04 東洋紡績株式会社 標本用プレート供給装置
JP2015120601A (ja) 2015-02-26 2015-07-02 武藤化学株式会社 スライドガラスカセット及びスライドガラス収容器
JP6433859B2 (ja) 2015-07-29 2018-12-05 株式会社日立ハイテクノロジーズ 自動分析装置
CN206331178U (zh) 2016-12-20 2017-07-14 洪树和 显微镜玻片供应器

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60170321U (ja) * 1984-04-20 1985-11-12 三共株式会社 スライドガラス供給装置
JPH0221951U (enrdf_load_stackoverflow) * 1988-07-28 1990-02-14
JP2017201285A (ja) * 2016-04-28 2017-11-09 シスメックス株式会社 検体塗抹装置

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