WO2021025131A1 - Dispositif microfluidique - Google Patents

Dispositif microfluidique Download PDF

Info

Publication number
WO2021025131A1
WO2021025131A1 PCT/JP2020/030248 JP2020030248W WO2021025131A1 WO 2021025131 A1 WO2021025131 A1 WO 2021025131A1 JP 2020030248 W JP2020030248 W JP 2020030248W WO 2021025131 A1 WO2021025131 A1 WO 2021025131A1
Authority
WO
WIPO (PCT)
Prior art keywords
solution
flow path
main flow
air
supply device
Prior art date
Application number
PCT/JP2020/030248
Other languages
English (en)
Japanese (ja)
Inventor
真利子 植村
勝 南口
Original Assignee
パナソニックＩｐマネジメント株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by パナソニックＩｐマネジメント株式会社 filed Critical パナソニックＩｐマネジメント株式会社
Priority to JP2021537389A priority Critical patent/JP7145468B2/ja
Publication of WO2021025131A1 publication Critical patent/WO2021025131A1/fr

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
    • B05B7/26—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device

Definitions

  • the present invention relates to a microfluidic device, more specifically, a microfluidic device that efficiently diffuses a component to be diffused into the air.
  • microchemical chips that perform chemical analysis and chemical synthesis by applying micromachine technology have been known, and microchemical chips having a plurality of microchannels are also known (for example, Patent Document 1). ..
  • the present invention has been made in view of such a problem, and an object of the present invention is to provide a microfluidic device capable of suppressing mixing of different components to be diffused in the air.
  • the microfluidic device includes a microchannel chip.
  • the microchannel chip includes a main channel, a first branch channel, a second branch channel, an air introduction section, and an atomizing section.
  • the main flow path is a micro flow path having one end and the other end.
  • the first branch flow path is connected to the main flow path between the one end and the other end of the main flow path.
  • the first branch flow path is a flow path of the first solution.
  • the second branch flow path is connected to the main flow path between the one end and the other end of the main flow path.
  • the second branch flow path is a flow path of a second solution different from the first solution.
  • the air introduction portion is connected to the main flow path at one end side of each position where the first branch flow path and the second branch flow path are connected in the main flow path. Air is supplied to the air introduction section.
  • the atomizing portion is provided on the side opposite to the one end when viewed from the other end of the main flow path. A liquid composed of any one of the first solution and the second solution is supplied to the atomizing section through the main flow path.
  • the microfluidic device further includes an atomizing device, an air supply device, a first solution supply device, a second solution supply device, and a control device.
  • the atomizing device applies energy to the liquid in the atomizing portion to atomize the liquid.
  • the air supply device supplies air to the air introduction section.
  • the first solution supply device supplies the first solution to the first branch flow path.
  • the second solution supply device supplies the second solution to the second branch flow path.
  • the control device drives and controls the atomizing device, the air supply device, the first solution supply device, and the second solution supply device. In the microfluidic device, the liquid in the atomizing section is atomized by the energy from the atomizing device.
  • the control device drives the first solution supply device to supply the first solution to the main flow path, stops supplying the first solution to the main flow path, and then causes the air supply device. It is driven to supply air to the main flow path to push out at least a part of the first solution in the main flow path, and then the second solution supply device is driven to supply the second solution to the main flow path. Supply.
  • the microfluidic device includes a microchannel chip.
  • the microchannel chip includes a main channel, three or more branch channels, an air introduction section, a compounding section, and an atomizing section.
  • the main flow path is a micro flow path having one end and the other end.
  • the three or more branch flow paths are connected to the main flow path between the one end and the other end of the main flow path, and have a one-to-one correspondence with three or more kinds of solutions different from each other.
  • the air introduction portion is connected to the main flow path at one end side of each position where the three or more branch flow paths are connected in the main flow path. Air is supplied to the air introduction section.
  • the compounding section is provided between each position and the other end in the main flow path.
  • the atomizing portion is provided on the side opposite to the one end when viewed from the other end of the main flow path.
  • the compounding solution prepared in the compounding section is supplied through a part of the main flow path.
  • the microfluidic device further includes an atomizing device, an air supply device, three or more solution supply devices, and a control device.
  • the atomizing device applies energy to a liquid composed of a mixed liquid supplied to the atomizing unit to atomize the liquid.
  • the air supply device supplies air to the air introduction section.
  • the three or more solution supply devices have a one-to-one correspondence with the three or more branch flow paths.
  • the control device drives and controls the atomizing device, the air supply device, and the three or more solution supply devices.
  • the control device drives two or more solution supply devices of the three or more solution supply devices, and prepares at least two kinds of solutions of the three or more kinds of solutions in the main flow path. After supplying as the compounding solution of No. 1 and stopping the supply of the first compounding solution, the air supply device is driven to supply air to the main flow path and the first compounding solution in the main flow path. At least a part of the above three or more solutions is extruded, and then two or more of the three or more solution supply devices are driven into the main flow path, and at least two of the three or more kinds of solutions are driven into the main flow path. Various solutions are mixed and supplied as a second preparation.
  • FIG. 1 is a schematic configuration diagram of the microfluidic apparatus according to the first embodiment.
  • FIG. 2A is a plan view of the microfluidic chip in the same microfluidic device.
  • FIG. 2B is a sectional view taken along line XX of FIG. 2A.
  • FIG. 2C is a sectional view taken along the line YY of FIG. 2A.
  • FIG. 3A is a plan view of the microchannel chip and the atomizer in the same microfluidic device.
  • FIG. 3B is a sectional view taken along line XX of FIG. 3A.
  • FIG. 4A is a plan view of the microchannel chip and the atomizer in the same microfluidic device.
  • FIG. 4B is a sectional view taken along line XX of FIG. 4A.
  • FIG. 5A is a plan view of the microchannel chip and the atomizer in the same microfluidic device.
  • FIG. 5B is a sectional view taken along line XX of FIG. 5A.
  • FIG. 6 is a flowchart showing an operation example 1 of the control device in the microfluidic device according to the first embodiment.
  • 7A to 7C are operation explanatory views of the same microfluidic device.
  • FIG. 8 is a schematic configuration diagram of the microfluidic device according to the third embodiment.
  • FIG. 9 is a flowchart showing an operation example 2 of the control device in the same microfluidic device.
  • the microfluidic device 1 applies energy (for example, surface acoustic wave energy) to a solution 8 containing a component to be diffused in the air to atomize the solution 8.
  • the microfluidic device 1 transports the solution 8 to the atomizing section 23 of the microchannel chip 2 and gives energy from the atomizing device 4 to the liquid (solution 8) existing in the atomizing section 23 to supply the liquid.
  • the microfluidic device 1 is a liquid atomization system that atomizes a liquid.
  • the solution 8 containing a component to be diffused into the air is, for example, an aroma oil containing a scent component, a cosmetological liquid, a medical liquid containing a medicinal component, or the like. A plurality of types of this solution 8 are prepared.
  • the microfluidic device 1 includes a microfluidic chip 2, a plurality of solution supply devices 3, an atomization device 4, an air supply device 5a, a cleaning liquid supply device 5b, a control device 6, and a drive device 7. Be prepared.
  • the microchannel chip 2 has a laminated structure of two substrates 20a and 20b.
  • the microchannel chip 2 is formed by forming a flow path forming recess on at least one of the two substrates 20a and 20b (for example, the substrate 20a), and these two substrates 20a and 20b are bonded together. Will be done.
  • the flow path forming recess is formed at a position corresponding to each of the main flow path 21 and the plurality of branch flow paths 25.
  • the micro flow path chip 2 includes a main flow path 21 which is a micro flow path through which the solution 8 flows, a plurality of branch flow paths 25, an air introduction section (air supply section) 22, an atomization section 23, and a plurality of solutions.
  • An introduction section (solution supply section) 24 and a section are formed.
  • the material of the microchannel chip 2 is silicon, but the material is not limited to this, and may be resin or glass, and is not particularly limited.
  • the “material of the microchannel chip 2” is the material of the above-mentioned two substrates 20a and 20b.
  • the microchannel chip 2 has a rectangular shape when viewed from its thickness direction D1 (see FIG. 2B) (see FIG. 2A).
  • the length of the microchannel chip 2 in the longitudinal direction when viewed from the thickness direction D1 of the microchannel chip 2 is, for example, 50 mm to 60 mm, but is not limited to this.
  • the length of the microchannel chip 2 in the lateral direction when viewed from the thickness direction D1 of the microchannel chip 2 is, for example, 20 mm to 30 mm, but is not limited to this.
  • the thickness of the microchannel chip 2 is 0.5 mm, but is not limited to this.
  • the main flow path 21 is a microflow having a substantially semicircular cross section (see FIG. 2C) and having one end 211 (hereinafter, also referred to as the first end 211) and the other end 212 (hereinafter, also referred to as the second end 212).
  • the main flow path 21 is a flow path through which the solution 8 flows and has a linear shape.
  • One end of the main flow path 21 is the first end 211, and the other end of the main flow path 21 is the second end 212.
  • the introduction portion 22 is formed.
  • An atomizing portion 23 to which a liquid (solution 8) is supplied through the main flow path 21 is formed on the side opposite to the first end 211 when viewed from the second end 212 of the main flow path 21.
  • the diameter of the main flow path 21 is, for example, 10 ⁇ m to 200 ⁇ m.
  • the main flow path 21 may have a rectangular cross section.
  • the "cross section of the main flow path 21" is a cross section orthogonal to the length direction of the main flow path 21 and is a cross section orthogonal to the flow direction of the liquid in the main flow path 21.
  • the air introduction portion 22 and the atomization portion 23 are holes formed by penetrating each of the two substrates 20a and 20b in the thickness direction of one of the substrates 20a, and are substantially circular in a plan view.
  • One substrate 20a is, for example, a silicon substrate.
  • the air introduction portion 22 and the atomization portion 23 are formed in connection with the main flow path 21.
  • the "planar view substantially circular" means that the substrate 20a is substantially circular when viewed from the thickness direction.
  • the thickness direction of one of the substrates 20a is the same as the thickness direction D1 of the microchannel chip 2.
  • the substrate 20a on which the air introduction portion 22 and the atomizing portion 23 are formed is referred to as a first substrate 20a among the two substrates 20a and 20b, and the first of the two substrates 20a and 20b
  • the substrate 20b bonded to the 1 substrate 20a is also referred to as a second substrate 20b.
  • the above-mentioned recess for forming a flow path is formed, for example, on the main surface of the first substrate 20a on the side of the second substrate 20b.
  • Each of the plurality of branch flow paths 25 has a straight line shape.
  • the plurality of branch flow paths 25 are micro flow paths for supplying a solution to the main flow path 21, and are formed by branching from the main flow path 21, respectively.
  • a plurality of branch flow paths 25 may be branched from one place of the main flow path 21, and are not particularly limited.
  • first branch flow path 251, the second branch flow path 252, and the third branch flow path 253, which are three branch flow paths in the plurality of branch flow paths 25, will be described.
  • the number of branch flow paths 25 of the above may be two or more, and may be four or five, and is not particularly limited. As the number of branch channels 25 increases, more different types of scent components can be released from the microfluidic device 1.
  • the air introduction section 22 is provided closer to the first end 211 of the main flow path 21 than the first branch flow path 251, the second branch flow path 252, and the third branch flow path 253.
  • the air introduction portion 22 and the first end 211 of the main flow path 21 are directly connected.
  • the distance between the air introduction portion 22 and the first end 211 of the main flow path 21 is the distance between the first branch flow path 251 and the second branch flow path 252, the third branch flow path 253, and the first end 211 of the main flow path 21. Shorter than the distance.
  • the plurality of solution introduction portions 24 are holes formed so as to penetrate the first substrate 20a of the microchannel chip 2 in the thickness direction of the first substrate 20a.
  • the solution introduction section 24 formed for supplying the solution 8 to the first branch flow path 251 is used to supply the solution 8 to the first solution introduction section 241 and the second branch flow path 252.
  • the solution introduction section 24 formed in the above is defined as the second solution introduction section 242
  • the solution introduction section 24 formed for supplying the solution 8 to the third branch flow path 253 is defined as the third solution introduction section 243.
  • the solution 8 supplied to the first solution introduction unit 241 is supplied to the first solution 81
  • the solution 8 supplied to the second solution introduction unit 242 is supplied to the second solution 82
  • the solution 8 supplied to the third solution introduction unit 243 Is defined as the third solution 83.
  • the second solution 82 is a solution containing a scent component different from that of the first solution 81.
  • the first solution 81 contains, for example, the scent component of cypress, and the second solution 82 is, for example, a solution containing the scent component of roses, but is not limited thereto.
  • a second solution 82 of a type determined with reference to the idea that the scents at the opposite poles of the fragrance wheel are incompatible with each other may be prepared.
  • the third solution 83 is a solution containing a scent component different from that of the first solution 81 and the second solution 82.
  • the first branch flow path 251 is a micro flow path for supplying the first solution 81 supplied from the first solution introduction unit 241 to the main flow path 21.
  • the second branch flow path 252 is a micro flow path for supplying the second solution 82 supplied from the second solution introduction unit 242 to the main flow path 21.
  • the third branch flow path 253 is a micro flow path that supplies the third solution 83 supplied from the third solution introduction unit 243 to the main flow path 21.
  • the first solution 81, the second solution 82, or the third solution 83 supplied to the main flow path 21 is sent to the atomizing section 23 by capillary force (capillary force) in the main flow path 21.
  • the first solution 81, the second solution 82, or the third solution 83 supplied to the main flow path 21 are provided in the first solution supply device 31, the second solution supply device 32, and the third solution supply device 36, respectively.
  • the solution may be sent by the pump, and is not particularly limited.
  • the control device 6 is the first solution supply device 31, so that the first solution 81, the second solution 82, and the third solution 83 are not supplied to the main flow path 21 at the same time.
  • the second solution supply device 32 and the third solution supply device 36 are controlled.
  • the atomizing portion 23 is provided on the side opposite to the first end 211 when viewed from the second end 212 of the main flow path 21 in a plan view from the thickness direction D1 of the micro flow path chip 2.
  • the atomizing unit 23 is supplied with a liquid (solution 8) composed of any one of the first solution 81, the second solution 82, and the third solution 83.
  • the plurality of solution supply devices 3 are connected to a plurality of solution introduction portions 24 of the microchannel chip 2.
  • the solution supply device 3 for supplying the first solution 81 to the first solution introduction unit 241 is the first solution supply device 31, and the solution supply device 3 for supplying the second solution 82 to the second solution introduction unit 242 is described.
  • the solution supply device 3 that supplies the third solution 83 to the second solution supply device 32 and the third solution introduction unit 243 is defined as the third solution supply device 36.
  • the number of the solution supply devices 3 may be the same as the number of the solution introduction units 24, and is not particularly limited.
  • the first solution supply device 31 includes a tank 30 storing the first solution 81, a pump 33 for supplying the first solution 81 to the first solution introduction unit 241, a pump 33, and a first solution introduction unit 241.
  • a tube 34 for connecting and a connector 35 for connecting the tube 34 to the first solution introduction unit 241 are provided.
  • the pump 33 is driven by the control device 6 to send the first solution 81.
  • the tube 34 is made of a corrosion resistant resin.
  • the tube 34 supplies the first solution 81 fed by the pump 33 from the first solution supply device 31 to the first solution introduction unit 241.
  • the connector 35 is provided at one end of the tube 34 and is fixed to the microchannel chip 2. As a result, a part of the tube 34 is inserted into the first solution introduction section 241.
  • the connector 35 has, for example, an O-ring that contacts the entire circumference of the outer peripheral surface of the tube 34.
  • the connector 35 may be provided with a fixture so that the tube 34 does not come off from the first solution introduction portion 241 due to the pressure of the first solution 81 sent by the pump 33.
  • the second solution supply device 32 has substantially the same configuration as the first solution supply device 31 except for the tank 30 that stores the second solution 82, the description thereof will be omitted.
  • the third solution supply device 36 has substantially the same configuration as the first solution supply device 31 except for the tank 30 that stores the third solution 83, and thus the description thereof will be omitted.
  • the atomizing device 4 is a device for atomizing the first solution 81, the second solution 82, or the third solution 83 sent from the main flow path 21 to the atomizing unit 23.
  • the atomizer 4 is, for example, a SAW (Surface Acoustic Wave) device 40 (see FIGS. 3A and 3B).
  • the SAW device includes an IDT (Interdigital Transducer) electrode on a piezoelectric substrate.
  • the SAW device 40 has, for example, a piezoelectric substrate 401 and an IDT electrode 402 formed on the piezoelectric substrate 401, as shown in FIGS. 3A and 3B.
  • the IDT electrode 402 generates a surface acoustic wave on the piezoelectric substrate 401.
  • the energy of the surface acoustic wave generated by the SAW device 40 is applied to the liquid supplied to the atomizing unit 23 to atomize the liquid.
  • droplet particles are generated by atomizing the liquid (solution 8) supplied to the atomizing unit 23.
  • the microfluidic chip 2 may also use the second substrate 20b as the piezoelectric substrate 401 of the SAW device 40, as shown in FIGS. 4A and 4B.
  • the atomizing device 4 is not limited to the SAW device 40, but is, for example, an ultrasonic atomizing device 41 (see, for example, FIGS. 5A and 5B) that applies ultrasonic energy to a liquid to atomize the liquid. It is also good, and there is no particular limitation. As shown in FIGS. 5A and 5B, for example, the ultrasonic atomizer 41 is arranged inside the ring-shaped ultrasonic vibrator 411 and the ultrasonic vibrator 411 to transmit the ultrasonic vibration of the ultrasonic vibrator 411. It has a metal mesh 412 and the like. The ultrasonic atomizing device 41 is arranged on the microchannel chip 2 so as to cover the atomizing portion 23. The ultrasonic atomizing device 41 gives energy (ultrasonic energy) to the liquid supplied to the atomizing unit 23 and discharges the atomized droplet particles from the metal mesh 412.
  • an ultrasonic atomizing device 41 see, for example, FIGS. 5A and 5B
  • one type of solution 8 (liquid) of the first solution 81, the second solution 82, and the third solution 83 is atomized and released by the atomizing unit 23.
  • the particle size of the droplet particles formed by atomizing the first solution 81, the second solution 82, or the third solution 83 is several tens of nm to several tens of ⁇ m.
  • the particle size refers to the median diameter (d50).
  • the flow rates of the first solution 81, the second solution 82, and the third solution 83 supplied to the atomizing unit 23 are, for example, 1 ⁇ L / min to 30 ⁇ L / min.
  • the control device 6 is a first solution supply device so that the flow rates of the first solution 81, the second solution 82, and the third solution 83 supplied to the atomizing unit 23 are, for example, 1 ⁇ L / min to 30 ⁇ L / min. 31. Drive and control each of the second solution supply device 32 and the third solution supply device 36.
  • the size of several tens of nm to several tens of ⁇ m formed by atomizing the first solution 81, the second solution 82, or the third solution 83 sent to the main flow path 21 It is possible to emit droplet particles having a particle size of.
  • the air supply device 5a connects a pump 33 for supplying air 91 (see FIG. 7B) to the air introduction unit 22, a tube 34 connecting the pump 33 and the air introduction unit 22, and the tube 34 and the air introduction unit 22. It is provided with a connector 35 for the purpose.
  • the pump 33 of the air supply device 5a sends air 91 to the air introduction unit 22 by being driven by the control device 6.
  • the tube 34 of the air supply device 5a is made of a corrosion-resistant resin.
  • the air supply device 5a supplies the air 91 sent by the pump 33 from the air supply device 5a to the air introduction unit 22.
  • the connector 35 of the air supply device 5a is provided at one end of the tube 34.
  • one end of the tube 34 is air so that there is no gap between the connector 35 and the air introduction portion 22 when the microchannel chip 2 is connected to the portion corresponding to the air introduction portion 22. It is inserted into the introduction unit 22.
  • the connector 35 of the air supply device 5a may be provided with a fixture so that the tube 34 does not come off from the air introduction portion 22 due to the pressure of the air 91 sent by the pump 33.
  • the microfluidic device 1 At least a part of the liquid (solution 8) in the main flow path 21 is pushed out by sending the air 91 to the main flow path 21 by the air supply device 5a. It is preferable to push out all of the liquid in the main flow path 21.
  • the control device 6 drives and controls the air supply device 5a
  • the air 91 is supplied from the air supply device 5a to the main flow path 21 to push out all the liquid in the main flow path 21 from the main flow path 21. It is preferable to take it out from the atomizing unit 23.
  • the cleaning liquid supply device 5b includes a tank 30 that stores the cleaning liquid 92, a pump 33 for supplying the cleaning liquid 92 to the air introduction unit 22, and a tube 34 that connects the pump 33 and the air introduction unit 22.
  • the connector 35 for connecting the tube 34 to the air introduction unit 22 may be shared with the connector 35 of the air supply device 5a, or may be provided separately.
  • the pump 33 of the cleaning liquid supply device 5b is driven by the control device 6 to send the cleaning liquid 92 to the air introduction unit 22.
  • the tube 34 of the cleaning liquid supply device 5b is made of a corrosion-resistant resin, and the cleaning liquid 92 sent by the pump 33 is supplied from the cleaning liquid supply device 5b to the air introduction unit 22.
  • the connector 35 of the cleaning liquid supply device 5b is provided at one end of the tube 34.
  • the air introduction unit is connected so that there is no gap between the air introduction unit 22 and the connector 35 when the micro flow path chip 2 is connected to the portion corresponding to the air introduction unit 22.
  • One end of the tube 34 is inserted into 22.
  • the connector 35 may be provided with a fixture so that the tube 34 does not come off from the air introduction portion 22 due to the pressure of the cleaning liquid 92 sent by the pump 33.
  • the cleaning liquid 92 is sent to the main flow path 21, so that the main flow path 21 is cleaned by the cleaning liquid 92.
  • the cleaning solution 92 for example, water, ethanol, or a mixed solution of ethanol and water is used.
  • the cleaning liquid 92 does not necessarily have to be a combination of the substances listed here.
  • the drive device 7 is electrically connected to the electrodes of the atomizing device 4 to vibrate the atomizing device 4.
  • the driving device 7 vibrates the surface of the piezoelectric substrate 401 by applying electric power (high frequency power) to the IDT electrode 402 (surface on the surface of the piezoelectric substrate 401). Generates surface acoustic waves).
  • the atomizing device 4 applies surface acoustic wave energy to the liquid (solution 8) supplied to the atomizing unit 23 to atomize the liquid.
  • the drive device 7 is driven by a battery 71 built in the drive device 7. Since the microfluidic device 1 incorporates the battery 71 in the drive device 7, the wiring required for the microfluidic device 1 can be reduced.
  • the battery 71 includes, for example, a primary battery, a secondary battery, a solar cell, and the like.
  • the battery is, for example, a secondary battery, which is provided in the drive device 7 in a state of being removable from the drive device 7. Therefore, the battery 71 in a state of being removed from the drive device 7 is charged, so that the battery 71 can be used repeatedly.
  • the drive device 7 includes a power supply circuit that supplies the electric power output from the battery 71 to the electrode (IDT electrode 402) of the atomizing device 4.
  • the power supply circuit includes, for example, an inverter that converts a DC voltage output from the battery 71 into an AC voltage.
  • the present invention is not limited to the above-mentioned example, and the drive device 7 may be driven by electric power from a commercial power source via a power supply cord (power cord), and is not particularly limited.
  • the control device 6 controls the operation of the first solution supply device 31, the second solution supply device 32, the third solution supply device 36, the air supply device 5a, the cleaning liquid supply device 5b, and the drive device 7.
  • the control device 6 includes a control unit 61, a drive control circuit 62, a sensor signal processing unit 63, and a switching unit 64.
  • the control unit 61 is equipped with a microcomputer or the like, and controls the operation of the entire control device 6 by executing a predetermined control program or the like.
  • the drive control circuit 62 includes a first solution 81 and a second solution 82 from the first solution supply device 31, the second solution supply device 32, the third solution supply device 36, the air supply device 5a, and the cleaning liquid supply device 5b, respectively. This is a circuit that controls (drive control) the supply amounts of the third solution 83, the air 91, and the cleaning liquid 92.
  • the sensor signal processing unit 63 processes the signal from the sensor unit.
  • the sensor unit is provided on the microchannel chip 2 and detects the state of the fluid (solution 8) in the main channel 21 of the microchannel chip 2 (for example, the presence / absence of liquid, the flow rate, and the type of liquid).
  • the switching unit 64 switches the drive of the first solution supply device 31, the second solution supply device 32, the third solution supply device 36, the air supply device 5a, and the cleaning liquid supply device 5b.
  • the control device 6 includes a power cord (not shown) for obtaining electric power for operating the control unit 61, the drive control circuit 62, the sensor signal processing unit 63, and the switching unit 64 from the outside. There is.
  • control device 6 may be provided with a battery as a power source inside, and is not particularly limited.
  • the first embodiment has a scent different from the first solution 81 containing a scent component to be diffused in the air, the second solution 82 containing a scent component different from the first solution 81, the first solution 81, and the second solution 82.
  • the liquid remaining in the main flow path 21 (for example, the first solution 81) is aired in order to prevent the different scent components from being mixed with each other.
  • the next liquid (for example, the second solution 82) is supplied to the main flow path 21, and the liquid supplied to the atomizing unit 23 is atomized by the atomizing device 4.
  • the control device 6 drives the cleaning liquid supply device 5b connected to the microchannel chip 2 to send the cleaning liquid 92 from the cleaning liquid supply device 5b.
  • the main flow path 21 is washed (S10).
  • the cleaning liquid 92 stored in the tank 30 of the cleaning liquid supply device 5b is flowed toward the main flow path 21 of the micro flow path chip 2.
  • the control device 6 stops the supply of the cleaning liquid 92 from the cleaning liquid supply device 5b to the main flow path 21 of the microchannel chip 2 by stopping the cleaning liquid supply device 5b (S30).
  • the control device 6 detects the completion of cleaning based on the output of the sensor unit.
  • the control device 6 is not limited to this, and a timer is provided in the control unit 61, and the cleaning liquid supply device 5b is micron for a predetermined time.
  • the cleaning liquid 92 may be supplied to the main flow path 21 of the flow path chip 2.
  • the sensor unit includes, for example, a light emitting device that projects light onto the liquid in the main flow path 21, and a light receiving device that receives light that is projected from the light emitting device and transmitted through the liquid in the main flow path 21.
  • the liquid is a colored liquid such as aroma
  • the cleaning liquid 92 is a colorless and transparent liquid such as ethanol
  • the completion of cleaning can be detected based on the amount of light received by the light receiving device.
  • the control device 6 is a solution supply device that stores, for example, a solution 8 containing a scent component (a solution 8 containing a scent component to be diffused in the air) determined by the user of the microfluidic device 1 in the tank 30.
  • the control device 6 drives, for example, a first solution supply device 31 containing the first solution 81 to send the first solution 81 from the first solution supply device 31 to the main flow path 21 of the microchannel chip 2. Let it liquid (S40).
  • the first solution 81 stored in the tank 30 of the first solution supply device 31 flows from the first branch flow path 251 through the first solution introduction section 241.
  • the right side of the alternate long and short dash line is a cross section along the X-ray cross section of FIG. 2A
  • the left side of the alternate long and short dash line is a cross section along the first branch flow path 251.
  • control device 6 stops driving the first solution supply device 31 to stop the supply of the first solution 81 from the first solution supply device 31 to the main flow path 21 of the microchannel chip 2 (S60). ).
  • the control device 6 drives the air supply device 5a to send the air 91 from the air supply device 5a to the main flow path 21 of the micro flow path chip 2 (S80).
  • the air 91 is supplied from the air supply device 5a to the main flow path 21 through the air introduction unit 22, and at least a part of the first solution 81 in the main flow path 21 is supplied. It is extruded by air 91.
  • FIG. 7B corresponds to the X-ray cross section of FIG. 2A.
  • control device 6 determines that the first solution 81 in the main flow path 21 has been sent out based on the signal from the sensor unit, and stops the drive of the air supply device 5a, thereby causing the mainstream.
  • the supply of air 91 to the road 21 is stopped (S100).
  • control device 6 determines, for example, whether or not to end the operation (S110).
  • the control device 6 drives the solution supply device 3 that stores the solution 8 containing the scent component different from the scent component contained in the first solution 81 in the tank 30.
  • the control device 6 drives, for example, a second solution supply device 32 including the second solution 82 to send the second solution 82 from the second solution supply device 32 to the main flow path 21 of the microchannel chip 2.
  • the second solution 82 stored in the tank 30 of the second solution supply device 32 flows from the second branch flow path 252 through the second solution introduction section 242. It is supplied to the road 21 and supplied to the atomizing unit 23.
  • the microfluidic device 1 can suppress the atomization of the first solution 81 and the atomization of the second solution 82 at the same time.
  • the right side of the alternate long and short dash line is a cross section along the X-ray cross section of FIG. 2A
  • the left side of the alternate long and short dash line is a cross section along the second branch flow path 252.
  • the control device 6 if the control device 6 operates from S40 to S100 and then determines that it is not terminated in S110, the control device 6 returns to S40 and drives, for example, a third solution supply device 36 containing the third solution 83.
  • the third solution 83 is sent from the third solution supply device 36 to the main flow path 21 of the microchannel chip 2 (S40).
  • the third solution 83 stored in the tank of the third solution supply device 36 flows from the third branch flow path 253 to the main flow path 21 through the third solution introduction section 243 and is atomized. It is supplied to 23.
  • the user determines in advance the input device of the control device 6. It can be decided by using such as.
  • the input device is, for example, the user's preference for scent, the environment in which the microfluidic device 1 is used (usage scene), the time zone in which the scent component is to be released (for example, morning, noon, night, etc.) or It is configured so that the type of solution to be atomized and the time zone or time can be linked and input in consideration of time and the like.
  • the control device 6 can create a program in which the type of the solution to be atomized is associated with the time zone or time based on the input of the input device, and the operation of the flowchart of FIG. 6 is performed based on this program. .. Therefore, for example, when the user wants to diffuse different fragrance components into the air at different time zones, different solutions (for example, first solution and second solution) are not continuously supplied to the main flow path 21. , At least a part of the first solution 81 can be pushed out from the main flow path 21 by inserting air 91 between different solutions (first solution, second solution). As a result, by suppressing the mixing of the first solution 81 and the second solution 82 in the main flow path 21, it is possible to easily suppress the mixing of different components to be diffused in the air.
  • different solutions for example, first solution and second solution
  • microfluidic device 1 for example, it is possible to prevent the scent components of cypress and rose from being mixed and diffused into the air, which is unpleasant for humans.
  • the air 91 supplied to the main flow path 21 can be discharged into the air from the atomizing unit 23 in the same manner as the solution 8. Therefore, when switching the scent component, it is not necessary to use the cleaning liquid 92, and the microfluidic device 1 can be miniaturized.
  • the first solution 81 previously contained in the main flow path 21 can be pushed out by the air 91, so that the scent can be obtained.
  • the daily running cost can be reduced as compared with the case where the cleaning liquid 92 is supplied into the main flow path 21 each time.
  • the microfluidic device 1 atomizes the solution 8 containing the bactericidal medicinal component and diffuses it into the air.
  • the first solution 81 is a solution containing a bactericidal medicinal component
  • the second solution 82 is a solution containing a bactericidal medicinal component different from the first solution 81.
  • the microfluidic device 1 of the second embodiment is installed in a living room such as an office, and atomizes a solution 8 containing a component for preventing infectious diseases such as influenza and diffuses it into the air.
  • a living room such as an office
  • the user in the living room where the microfluidic device 1 is installed can take preventive measures against infectious diseases while working in the office, for example.
  • FIG. 8 is a schematic configuration diagram of the microfluidic device 1 according to the third embodiment. As shown in FIG. 8, the microfluidic device 1 according to the third embodiment is used to prepare two or more kinds of target liquids, such as a first solution 81 and a second solution 82, from a plurality of kinds (three kinds or more) of solutions 8. A blending unit 100 for blending is further provided.
  • the compounding unit 100 is formed on, for example, the microchannel chip 2.
  • the microfluidic device 1 discharges droplet particles having a size of several tens of nm to several tens of ⁇ m formed by atomizing the prepared liquid produced by mixing two or more kinds of target liquids in the mixing unit 100. Can be done.
  • the second solution 82 is a solution containing a scent component different from that of the first solution 81.
  • the first solution 81 contains, for example, a hinoki scent component
  • the second solution 82 contains, for example, a scent component that does not give a human-unpleasant scent even when mixed with the hinoki scent component.
  • the third solution 83 is a solution containing a scent component different from that of the first solution 81 and the second solution 82, and contains, for example, a rose scent component.
  • a first solution 81 containing a scent component to be diffused in the air and a second solution 82 containing a scent component different from the first solution 81 are prepared by the mixing unit 100. Even if the third solution 83 containing a fragrance component different from that of the first solution 81 and the second solution 82 is supplied after atomization, the mixed solution of the first solution 81 and the second solution 82 and the third solution 83
  • the feature is that at least a part of the preparation solution is extruded with air after the preparation solution of the first solution 81 and the second solution 82 is supplied and before the third solution 83 is supplied in order to prevent the mixture from being mixed with each other.
  • this point will be described with reference to the flowchart shown in FIG. 9 for the operation of the control device 6. The same operation as the control device 6 of the microfluidic device 1 according to the first embodiment will be omitted as appropriate.
  • the control device 6 includes two solution supply devices 3 (for example, the first solution 81) among the plurality of solution supply devices 3.
  • the 1 solution supply device 31 and the second solution supply device 32) including the second solution 82 are driven to transfer two types of solutions (first solution 81 and second solution 82) to the main flow path of the microchannel chip 2. It is supplied to 21 and prepared by the compounding unit 100, and the compounding solution (first compounding solution) of the first solution 81 and the second solution 82 is supplied to the atomizing unit 23 (S31).
  • the microfluidic device 1 atomizes the liquid composed of the compound liquid supplied to the atomizing unit 23 by the atomizing device 4, so that the scent component in which a plurality of types of scent components are mixed can be released into the air.
  • the control device 6 stops driving the two solution supply devices 3 (first solution supply device 31 and the second solution supply device 32), and the two solution supply devices 3 (first solution supply device 31 and the second solution supply device 32) are stopped.
  • the supply of the two types of solutions 8 (first solution 81 and second solution 82) from the second solution supply device 32) to the main flow path 21 of the microchannel chip 2 is stopped (S60).
  • the control device 6 drives the air supply device 5a to send the air 91 from the air supply device 5a to the main flow path 21 of the micro flow path chip 2 (S80).
  • control device 6 determines that the compound liquid in the main flow path 21 has been sent out based on the signal from the sensor unit, and stops the drive of the air supply device 5a, whereby the main flow path 21 The supply of air 91 to the air 91 is stopped (S100).
  • control device 6 determines, for example, whether or not to end the operation (S110). When ending the operation (NO in S110), the power is turned off. On the other hand, when the operation is not terminated (YES in S110), the process returns to S31.
  • the control device 6 drives only one solution supply device 3 (third solution supply device 36) when returning from S110 to S31, but the two solution supply devices 3 (for example, the second solution).
  • the second solution 82 and the third solution 83 are driven to drive the supply device 32 and the third solution supply device 36), and the second solution 82 and the third solution 83 are mixed by the compounding unit 100 to prepare a second solution of the second solution 82 and the third solution 83.
  • the prepared solution of the above may be supplied to the atomizing unit 23 to atomize it.
  • the control device 6 prepares, for example, three kinds of solutions 8 (first solution 81, second solution 82, third solution 83) having different scent components in the mixing unit 100 and atomizes the solution.
  • the three solution supply devices 3 may be driven so as to be supplied to the 23, or four or more kinds of solutions 8 having different scent components may be mixed by the mixing unit 100 and supplied to the atomizing unit 23. , There is no particular limitation.
  • the microchannel chip 2 includes the first solution 81, the second solution 82, and the second solution 83.
  • a fourth solution or a fifth solution containing a scent component different from that of the third solution 83 may be supplied.
  • a fourth solution supply device (not shown) or a fifth solution supply device (not shown) for supplying the fourth solution is provided accordingly.
  • the fourth solution supply device may be driven to send the fourth solution to the main flow path 21 by returning to S40.
  • the microfluidic device 1 can diffuse the scent component contained in the fourth solution into the air.
  • the scent components contained in the solution 8 include, for example, orange bitter, orange sweet, oregano, opoponax, elemi, oak moss, winter green, iris, ylang ylang, immortelle, inula, ambread seed, anjulica root, carnation, etc.
  • Garlic Kananga, Kabosu, Chamomile German, Chamomile Roman, Kaya, Kayupte, Karamas, Caramint, Galangal, Cardamon, Galvanum, Caraway, Carrot Seed, Kinmokusei, Quera, Kusunoki, Kumin, Clarisage, Grapefruit, Crawl, Chromoji, Getto, Koyamaki, Costas, Copaiba, Coriander, Perilla, Cinnamon Burke, Jasmine, Ginger, Sugi, Sudachi, Sage, Turmeric, Parsley, Hakka, Vanilla, Bitter Almond, Hyacinth, Black Pepper, Peppermint, Bergamot, Bergamot Mint, Myrtle, It may be mustard, mimosa, melissa, fir, yuzu, lime, lavender, lemon, lemongrass, rose absolute, bergamot, rosemary cineole and the like. Further, the solution 8 may be mixed with the above-mentioned scent components as long as it is not an unpleasant scent component by humans, and is not
  • the microfluidic device 1 can atomize various different scent components and diffuse them into the air.
  • control unit 61 may drive the cleaning liquid supply device 5b to clean the main flow path 21 of the micro flow path chip 2 with the cleaning liquid 92.
  • the microfluidic device 1 can be stopped without leaving the solution 8 in the main flow path 21.
  • the solution supply device 3 may have a structure capable of appropriately replenishing the solution 8 stored in the tank 30.
  • the solution 8 is supplied to the solution introduction unit 24 by the solution supply device 3, but the solution 8 may be supplied by a syringe pump or the like.
  • the above-mentioned microfluidic device 1 is provided in a living space such as a living room, a dining room, a bedroom, a conference room in an office, a nap room in an office, a centralized booth in an office, etc., but is not particularly limited.
  • the microfluidic device (1) includes a microfluidic chip (2).
  • the micro flow path chip (2) includes a main flow path (21), a first branch flow path (251), a second branch flow path (252), an air introduction section (22), and an atomization section (23). And, including.
  • the main flow path (21) is a micro flow path having one end (211) and the other end (212).
  • the first branch flow path (251) is connected to the main flow path (21) between one end (211) and the other end (212) of the main flow path (21).
  • the first branch flow path (251) is a flow path of the first solution (81).
  • the second branch flow path (252) is connected to the main flow path (21) between one end (211) and the other end (212) of the main flow path (21).
  • the second branch flow path (252) is a flow path of the second solution (82) different from the first solution (81).
  • the air introduction section (22) has a main flow path (21) at one end (211) side of each position where the first branch flow path (251) and the second branch flow path (252) are connected in the main flow path (21). ) Is connected. Air is supplied to the air introduction section (22).
  • the atomizing portion (23) is provided on the side opposite to one end (211) when viewed from the other end (212) of the main flow path (21).
  • the atomizing section (23) is supplied with a liquid composed of any one of the first solution (81) and the second solution (82) through the main flow path (21).
  • the microfluidic device (1) includes an atomizing device (4), an air supply device (5a), a first solution supply device (31), a second solution supply device (32), and a control device (6). , Are further provided.
  • the atomizer (4) applies energy to the liquid in the atomizing section (23) to atomize the liquid.
  • the air supply device (5a) supplies air to the air introduction unit (22).
  • the first solution supply device (31) supplies the first solution (81) to the first branch flow path (251).
  • the second solution supply device (32) supplies the second solution (82) to the second branch flow path (252).
  • the control device (6) drives and controls the atomizing device (4), the air supply device (5a), the first solution supply device (31), and the second solution supply device (32).
  • the liquid in the atomizing section (23) is atomized by the energy from the atomizing device (4).
  • the control device (6) drives the first solution supply device (31) to supply the first solution (81) to the main flow path (21), and supplies the first solution (81) to the main flow path (21).
  • the air supply device (5a) is driven to supply air to the main flow path (21) to push out at least a part of the first solution (81) in the main flow path (21), and then
  • the second solution supply device (32) is driven to supply the second solution (82) to the main flow path (21).
  • the microfluidic device (1) according to the first aspect can suppress mixing of different components to be diffused in the air.
  • the microfluidic device (1) according to the first aspect can suppress continuous mixing of components to be diffused in the air.
  • Continuous mixing means that when it is desired to make the components diffused in the air different in time series, the first solution (81) containing the components diffused in the air first is then introduced into the air. It means that it is mixed with the second solution (82) containing a component to be diffused, then atomized and diffused in the air.
  • the first solution (81) and the second solution (82) contain different scent components.
  • the first solution (81) and the second solution (82) contain different bactericidal medicinal components.
  • the bactericidal component of the first solution (81) and the bactericidal component of the second solution (82) are prevented from being mixed and diffused into the air. Is possible.
  • the atomizing device (4) generates an elastic surface wave to atomize the liquid.
  • microfluidic apparatus (1) it is possible to generate droplet particles having a smaller particle size as compared with the case where ultrasonic waves are generated to atomize the liquid.
  • the microfluidic device (1) according to the fifth aspect further includes a cleaning liquid supply device (5b) that supplies the cleaning liquid (92) to the air introduction unit (22) in the first to fourth aspects.
  • the cleaning liquid supply device (5b) supplies the cleaning liquid (92) to the main flow path (21) through the air introduction unit (22).
  • the inside of the main flow path (21) can be cleaned with the cleaning liquid (92).
  • the microfluidic device (1) includes a microchannel chip (2).
  • the micro flow path chip (2) includes a main flow path (21), three or more branch flow paths (25), an air introduction section (22), a compounding section (100), and an atomization section (23). ,including.
  • the main flow path (21) is a micro flow path having one end (211) and the other end (212).
  • Three or more branch flow paths (25) are connected to the main flow path (21) between one end (211) and the other end (212) of the main flow path (21), and three or more kinds of solutions (21) different from each other ( There is a one-to-one correspondence with 8).
  • the air introduction portion (22) is connected to the main flow path (21) at one end (211) side of each position where the three or more branch flow paths (25) are connected in the main flow path (21).
  • Air (91) is supplied to the air introduction unit (22).
  • the compounding section (100) is provided between each position and the other end (212) in the main flow path (21).
  • the atomizing portion (23) is provided on the side opposite to one end (211) when viewed from the other end (212) of the main flow path (21). In the atomizing section (23), the compounding solution prepared in the compounding section (100) is supplied through a part of the main flow path (21).
  • the microfluidic device (1) further includes an atomizing device (4), an air supply device (5a), three or more solution supply devices (3), and a control device (6).
  • the atomizing device (4) applies energy to the liquid composed of the mixed liquid supplied to the atomizing unit (23) to atomize the liquid.
  • the air supply device (5a) supplies air to the air introduction unit (22).
  • the three or more solution supply devices (3) have a one-to-one correspondence with the three or more branch flow paths (25).
  • the control device (6) drives and controls the atomizing device (4), the air supply device (5a), and three or more solution supply devices (3).
  • the control device (6) drives two or more solution supply devices (3) out of three or more solution supply devices (3), and causes the main flow path (21) to have three or more kinds of solutions (8).
  • At least two kinds of solutions (8) of the above are mixed and supplied as the first mixed solution, and after the supply of the first mixed solution is stopped, the air supply device (5a) is driven to drive the main flow path (21).
  • the supply device (3) is driven to prepare at least two kinds of solutions (8) out of three or more kinds of solutions (8) in the main flow path (21) and supply them as a second preparation liquid.
  • the microfluidic device (1) according to the sixth aspect can suppress mixing of different components to be diffused in the air.
  • the microfluidic device (1) according to the sixth aspect can suppress continuous mixing of components to be diffused in the air.
  • Continuous mixing means that when it is desired to make the components diffused in the air different in chronological order, the first formulation containing the components to be diffused into the air first is then diffused into the air. It means that it is atomized and diffused in the air after being mixed with the second formulation containing the components to be made to.
  • the control device (6) uses the first formulation only when the second formulation contains a component different from that of the first formulation. After stopping the supply of the liquid, the air supply device (5a) is driven to supply air to the main flow path (21) to push out at least a part of the first preparation liquid in the main flow path (21).
  • Microfluidic device 2 Microchannel chip 21 Main channel 22 Air introduction section 23 Atomization section 24 Solution introduction section 241 First solution introduction section 242 Second solution introduction section 243 Third solution introduction section 25 Branch flow path 251 First branch Flow path 252 Second branch flow path 253 Third branch flow path 3 Solution supply device 31 First solution supply device 32 Second solution supply device 33 Pump 34 Tube 35 Connector 36 Third solution supply device 4 Atomizer 5a Air supply device 5b Cleaning liquid supply device 6 Control device 61 Control unit 62 Drive control circuit 63 Sensor signal processing unit 64 Switching unit 7 Drive device 71 Battery 8 Solution 81 First solution 82 Second solution 83 Third solution 91 Air 92 Cleaning liquid 100 Mixing unit

Landscapes

  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)

Abstract

La présente invention aborde le problème de la fourniture d'un dispositif microfluidique capable d'empêcher des composants qui ont été diffusés dans l'air de se mélanger. Un dispositif microfluidique (1) comprend un dispositif de commande (6) qui commande/entraîne un dispositif d'alimentation en air (5a), un premier dispositif d'alimentation en solution (31) et un second dispositif d'alimentation en solution (32). Le dispositif de commande (6) : entraîne le premier dispositif d'alimentation en solution (31) pour fournir une première solution (81) à un trajet d'écoulement principal (21) ; arrête l'alimentation de la première solution (81) vers le trajet d'écoulement principal (21), puis entraîne le dispositif d'alimentation en air (5a) pour fournir de l'air (91) vers le trajet d'écoulement principal (21) et pousse au moins une partie de la première solution (81) présente dans le trajet d'écoulement principal (21) ; et, par la suite, entraîne le second dispositif d'alimentation en solution (32) pour fournir une seconde solution (82) vers le trajet d'écoulement principal (21).
PCT/JP2020/030248 2019-08-08 2020-08-06 Dispositif microfluidique WO2021025131A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021537389A JP7145468B2 (ja) 2019-08-08 2020-08-06 マイクロ流体装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019145882 2019-08-08
JP2019-145882 2019-08-08

Publications (1)

Publication Number Publication Date
WO2021025131A1 true WO2021025131A1 (fr) 2021-02-11

Family

ID=74503868

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2020/030248 WO2021025131A1 (fr) 2019-08-08 2020-08-06 Dispositif microfluidique

Country Status (2)

Country Link
JP (1) JP7145468B2 (fr)
WO (1) WO2021025131A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07232114A (ja) * 1994-02-21 1995-09-05 Kanagawa Kagaku Gijutsu Akad 弾性表面波を用いた超音波霧化器
JP2003502114A (ja) * 1999-06-22 2003-01-21 シュテファン リュッツ テクノロジーズ 芳香放出装置およびアロマ貯蔵体（芳香チップ）
WO2010047110A1 (fr) * 2008-10-24 2010-04-29 パナソニック電工株式会社 Pulvérisateur à ondes acoustiques de surface
JP2010175360A (ja) * 2009-01-29 2010-08-12 Panasonic Corp マイクロ化学チップ
JP2012520174A (ja) * 2009-03-13 2012-09-06 プレジデント アンド フェローズ オブ ハーバード カレッジ マイクロ流体デバイスのスケールアップ
JP2019115598A (ja) * 2017-12-27 2019-07-18 国立大学法人東京工業大学 香り発生装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07232114A (ja) * 1994-02-21 1995-09-05 Kanagawa Kagaku Gijutsu Akad 弾性表面波を用いた超音波霧化器
JP2003502114A (ja) * 1999-06-22 2003-01-21 シュテファン リュッツ テクノロジーズ 芳香放出装置およびアロマ貯蔵体（芳香チップ）
WO2010047110A1 (fr) * 2008-10-24 2010-04-29 パナソニック電工株式会社 Pulvérisateur à ondes acoustiques de surface
JP2010175360A (ja) * 2009-01-29 2010-08-12 Panasonic Corp マイクロ化学チップ
JP2012520174A (ja) * 2009-03-13 2012-09-06 プレジデント アンド フェローズ オブ ハーバード カレッジ マイクロ流体デバイスのスケールアップ
JP2019115598A (ja) * 2017-12-27 2019-07-18 国立大学法人東京工業大学 香り発生装置

Also Published As

Publication number Publication date
JPWO2021025131A1 (fr) 2021-02-11
JP7145468B2 (ja) 2022-10-03

Similar Documents

Publication Publication Date Title
US7891580B2 (en) High volume atomizer for common consumer spray products
CN210386352U (zh) 微流量香薰雾化装置
US8016209B2 (en) Liquid droplet plug and spray system
US7490815B2 (en) Delivery system for dispensing volatile materials using an electromechanical transducer in combination with an air disturbance generator
CN107847721B (zh) 用于待用介质阻挡等离子体处理的表面的处理仪
US7793861B2 (en) Piston actuated vapor-dispersing device
US7793860B2 (en) Piston actuated vapor-dispersing device
US4085893A (en) Ultrasonic humidifiers, atomizers and the like
US20210268209A1 (en) Nebulizer
MXPA06014752A (es) Dispositivo atomizador de l??quido con sedimentacion reducida de gotitas de l??quido atomizadas.
JP2004504936A (ja) 漏洩を最小限とするエーロゾル状液体散布方法及び装置
KR20040002708A (ko) 공기청정기
TWM536948U (zh) 微霧化裝置及微霧化器
WO2021025131A1 (fr) Dispositif microfluidique
JP2006204968A (ja) 霧化装置
WO2007122583A2 (fr) Système de distribution pour diffuser des matières volatiles présentant une teneur élevée en substances solides au moyen d'un dispositif à transducteur électromécanique
KR102678412B1 (ko) 무균 에어로졸 미스팅 장치
JP2007190412A (ja) 空気清浄機
US8960568B2 (en) Brush wheel typed nebulizer
DE10306683A1 (de) Mikrodosiereinrichtung
JP2765474B2 (ja) 超音波振動装置及び霧化装置
WO2007144649A2 (fr) Alimentation pour dispositif d'atomisation
JP2013022196A (ja) ミスト発生装置及び美容装置
JP2021010878A (ja) 液体霧化システム及びミスト発生システム
JPH07328503A (ja) 超音波振動子および超音波霧化装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20850291

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2021537389

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20850291

Country of ref document: EP

Kind code of ref document: A1