WO2021017137A1 - 口香糖、电子烟液及其用途 - Google Patents

口香糖、电子烟液及其用途 Download PDF

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Publication number
WO2021017137A1
WO2021017137A1 PCT/CN2019/108302 CN2019108302W WO2021017137A1 WO 2021017137 A1 WO2021017137 A1 WO 2021017137A1 CN 2019108302 W CN2019108302 W CN 2019108302W WO 2021017137 A1 WO2021017137 A1 WO 2021017137A1
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WO
WIPO (PCT)
Prior art keywords
parts
ethyl
chewing gum
acetate
flavor
Prior art date
Application number
PCT/CN2019/108302
Other languages
English (en)
French (fr)
Inventor
许静
姜兴涛
Original Assignee
深圳雾芯科技有限公司
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Publication of WO2021017137A1 publication Critical patent/WO2021017137A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • This application relates to the field of electronic aerosols or electronic atomization devices, and in particular to a chewing gum and its application in the atomization device.
  • Chewing gum can clean the mouth and improve oral health, but its main residue is gum base, which is a high-molecular substance that is difficult to degrade and is not absorbed by the human body. It is difficult to clean up on the ground and carpet, and it is easy to stick to dust and dirt. Bacteria pollute the environment; if swallowed accidentally by children, it is easy to be dangerous; and chewing for a long time will have a negative effect on the face.
  • This application provides a chewing gum that does not contain colloids and a method of use thereof.
  • the chewing gum does not contain the gum base in traditional chewing gum, and its ingredients are easily degradable and edible, without the gum base residues in traditional chewing gum, and are not difficult to clean And pollution of the environment, no need to chew, will not have a negative impact on the face.
  • the chewing gum can generate aerosol that can be inhaled by the user through the atomization device, and can clean the oral cavity and prevent dental caries.
  • the present application provides a chewing gum comprising the following parts by weight: 10 to 50 parts of sweetener, 5 to 20 parts of cooling agent and 15 to 85 parts of propylene glycol;
  • the sweetener includes at least one of xylitol, maltose, stevia, rhamnose, trehalose, erythritol, lactose, and galactose.
  • the present application provides an electronic cigarette liquid, which includes the above-mentioned chewing gum.
  • the present application provides an atomization device, which includes the above-mentioned chewing gum or electronic cigarette liquid.
  • the present application provides a method for using the aforementioned chewing gum or e-cigarette liquid, wherein the chewing gum or e-cigarette liquid can be atomized by an atomizing device to generate aerosol for inhalation by the user.
  • the chewing gum or electronic cigarette liquid of the present application can play a role in cleaning the oral cavity or preventing dental caries.
  • the terms “substantially”, “substantially”, “substantially”, “substantially” and “about” are used to describe and illustrate small changes. When used in conjunction with an event or situation, the term may refer to an example in which the event or situation occurs precisely and an example in which the event or situation occurs very closely.
  • the term when used in conjunction with a value, the term may refer to a range of variation less than or equal to ⁇ 10% of the stated value, such as less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, Less than or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%.
  • the difference between two values is less than or equal to ⁇ 10% of the average value of the value (for example, less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, less than Or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%), then the two values can be considered "substantially" the same.
  • a list of items connected by the terms “at least one of”, “at least one of”, “at least one of” or other similar terms may mean the listed items Any combination of. For example, if items A and B are listed, then the phrase “at least one of A and B” means only A; only B; or A and B. In another example, if items A, B, and C are listed, then the phrase "at least one of A, B, and C” means only A; or only B; only C; A and B (excluding C); A and C (exclude B); B and C (exclude A); or all of A, B, and C.
  • Project A can contain a single element or multiple elements.
  • Project B can contain a single element or multiple elements.
  • Project C can contain a single element or multiple elements.
  • aerosol for user inhalation may include, but is not limited to, aerosol, suspended liquid, low-temperature vapor, and volatile gas.
  • the present application provides a chewing gum and a method of using the same, so that users can inhale the atomized chewing gum in a simpler and more environmentally friendly way to clean the oral cavity.
  • the present application provides an application of chewing gum in electronic cigarettes, so that users can clean their mouths and prevent dental caries while smoking electronic cigarettes.
  • the present application provides a chewing gum comprising the following parts by weight: about 10 to about 50 parts of sweetener, about 5 to about 20 parts of cooling agent, and about 15 to about About 85 parts of propylene glycol.
  • the weight of the sweetener in the chewing gum is roughly, for example, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts or these parts. The range of any two of them.
  • the weight of the cooling agent in the chewing gum is roughly, for example, 5 parts, 10 parts, 15 parts, 20 parts, or any two of these parts.
  • the weight of propylene glycol in the chewing gum is roughly, for example, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts , 70 parts, 75 parts, 80 parts, 85 parts, or any two of these parts.
  • Sweeteners are additives, which can make the product feel sweet when used.
  • Sweeteners can be divided into synthetic sweeteners and natural sweeteners according to their preparation methods.
  • artificial sweeteners include, but are not limited to, sodium saccharin, cyclamate, aspartame, and acesulfame K.
  • natural sweeteners include, but are not limited to, xylitol, maltose, stevia, rhamnose, trehalose, erythritol, lactose.
  • the sweetener is a natural sweetener, which includes selected from xylitol, maltose, stevia, rhamnose, trehalose, erythritol, lactose and galactose, and combinations thereof The group formed.
  • the sweetener is xylitol.
  • the chewing gum of the present application can achieve the effect of cleaning the oral cavity through the added xylitol.
  • Cooling agents are additives, which are chemicals that can give users a feeling of cooling effect when the product is used and are not very irritating.
  • the cooling agent includes selected from menthol, menthone, isomenthone, menthyl lactate, WS-23 (N,2,3-trimethyl-2-isopropylbutanamide) , WS-3(N-ethyl-p-menthyl-3-carboxamide), WS-5(N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS-12(N-( 4-Methoxyphenyl)-p-menthyl-3-carboxamide), menthyl acetate and combinations thereof.
  • the chewing gum further comprises the following parts by weight: about 0 to about 15 parts of the traditional Chinese medicine composition.
  • the weight of the Chinese medicinal composition in the chewing gum is approximately, for example, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 10 parts, 15 parts or any two of these parts. Range.
  • the traditional Chinese medicine composition includes one or more of lemon extract, magnolia bark extract, and green tea extract, wherein the lemon extract includes at least one of limonene, citral, and linalool.
  • the bark extract includes at least one of magnolol and honokiol, and the green tea extract includes at least one of tea polyphenols and caffeine.
  • the traditional Chinese medicine composition includes magnolol.
  • Lemon extract has antibacterial and free radical scavenging effects.
  • Magnolia Bark extract has antibacterial, scavenging free radicals, eliminating phlegm and relieving cough.
  • Green tea extract has anti-oxidant effects.
  • the chewing gum of the present application can achieve the effects of cleaning the oral cavity and preventing tooth decay through the added traditional Chinese medicine composition.
  • the lemon extract is obtained by extraction by steam distillation.
  • the steam distillation method includes the following steps: adding lemon or mint raw materials into a distillation flask, adding about 8 to about 15 times the mass of pure water, heating and distilling for about 3 hours to about 6 hours, and collecting the distillate To obtain lemon extract.
  • lemons can be fresh or dried (for example, dried in the shade).
  • the magnolia bark extract and the green tea extract are obtained by an organic solvent extraction method, and the organic solvent used for the extraction is ethanol with a volume fraction of about 40% to about 80%.
  • the organic solvent extraction method includes the following steps:
  • the extract is filtered, and after filtering, the residue is added to an ethanol solution of about 8 to about 15 times the mass and extracted at room temperature for about 12 hours to about 48 hours, and then filtered.
  • step (1) the Magnolia Bark extract is extracted with ethanol with a volume fraction of about 40% to about 60%, and the green tea extract is extracted with ethanol with a volume fraction of about 70% to about 80%.
  • step (2) when the macroporous resin is eluted, the Magnolia Bark extract is eluted with ethanol with a volume fraction of about 80% to about 90%; the green tea extract is eluted with a volume fraction of about 70% to about 90%. Elute with about 80% ethanol.
  • the macroporous resin is D-101 type non-polar resin.
  • the process conditions of freeze-drying in step (2) are: the pre-freezing temperature is about -20°C to about -50°C, the pre-freezing time is about 15 hours to about 30 hours, and the freeze-drying temperature is about The temperature is programmed from -40°C to about 20°C, the freeze-drying time is about 24 hours to about 72 hours, and the freeze-drying is carried out at a pressure of about 4Pa to about 107Pa.
  • the chewing gum further comprises the following parts by weight: about 0 to about 15 parts of flavor components, wherein the flavor components include limonene, citral, linalool, magnolol, tea At least one of phenol and caffeine.
  • the chewing gum of the present application can enhance the antibacterial effect and achieve the effect of cleaning the oral cavity through the added flavor components.
  • the aforementioned chewing gum can further include about 0.01 to about 25 parts by weight of flavor.
  • the content by weight of the flavor in the chewing gum is, for example, 0.01 part, 0.05 part, 0.1 part, 0.25 part, 0.5 part, 1 part, 5 parts, 10 parts, 15 parts, 20 parts, 25 parts or the range of any two of these parts.
  • the flavor is any flavor that can be used in the electronic cigarette liquid in the art, such as, but not limited to, watermelon flavor and green tea flavor.
  • the flavor comprises selected from ⁇ -pinene, benzyl alcohol, benzaldehyde, phenylacetaldehyde, benzyl benzoate, neral, nerol, geraniol, indole, jasmone, Neroli, myricetin, methyl dihydrojasmonate, dihydrokiwi lactone, eugenol, ⁇ -myrcene, cymene, diethyl sebacate, methyl 2-methylbutyrate, Ethyl 2-methylbutyrate, ethyl isovalerate, ⁇ -terpinene, ⁇ -terpineol, ⁇ -caprolactone, ⁇ -caprolactone, ⁇ -decanolactone, ⁇ -octylbutyl ester , ⁇
  • chewing gum of the embodiments of the present application can be manufactured by any suitable known method according to actual preparation requirements without limitation.
  • the present application provides an e-cigarette liquid, which includes the chewing gum in the above-mentioned embodiments.
  • the e-cigarette liquid comprises the following parts by weight: about 0.5 to about 20 parts of sweetener, about 0.25 to about 8 parts of cooling agent, about 0 to about 6 parts of flavor ingredients, or Chinese medicine composition, about 0 to about 5 parts of nicotine salt, about 30 to about 60 parts of glycerin, and about 10 to about 65 parts of propylene glycol; wherein the flavor ingredients include limonene, citral, linalool, and magnolol , At least one of tea polyphenols and caffeine, and the traditional Chinese medicine composition includes at least one of lemon extract, magnolia bark extract and green tea extract.
  • the weight content of the nicotine salt in the electronic cigarette liquid is, for example, 0 parts, 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 4 parts, 5 parts.
  • the nicotine salt comprises benzoate.
  • the e-cigarette liquid can further include about 0.01 to about 10 parts by weight of flavor.
  • the content by weight of the flavor in the chewing gum is, for example, 0.01 part, 0.05 part, 0.1 part, 0.25 part, 0.5 part, 1 part, 5 parts, 10 parts, or any two of these parts. The scope of the composition of the participants.
  • the flavor is any flavor that can be used in the electronic cigarette liquid in the art, such as, but not limited to, watermelon flavor and green tea flavor.
  • the flavor comprises selected from ⁇ -pinene, benzyl alcohol, benzaldehyde, phenylacetaldehyde, benzyl benzoate, neral, nerol, geraniol, indole, jasmone, Neroli, myricetin, methyl dihydrojasmonate, dihydrokiwi lactone, eugenol, ⁇ -myrcene, cymene, diethyl sebacate, methyl 2-methylbutyrate, Ethyl 2-methylbutyrate, ethyl isovalerate, ⁇ -terpinene, ⁇ -terpineol, ⁇ -caprolactone, ⁇ -caprolactone, ⁇ -decanolactone, ⁇ -octylbutyl ester , ⁇
  • the present application provides a method for preparing e-cigarette liquid, which includes the following steps: separately formulating nicotine salt and chewing gum, then mixing them in a specific ratio in the range provided in the examples, and then adding flavor and nicotine salt , Then add propylene glycol and glycerin and mix them evenly to obtain an electronic cigarette liquid.
  • the present application provides an atomization device, wherein the atomization device includes the chewing gum or electronic cigarette liquid in the above-mentioned embodiments.
  • the chewing gum or the electronic cigarette liquid can be atomized by the atomizing device to generate aerosol for the user to inhale.
  • the atomization device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
  • the e-cigarette liquid provided in the embodiments of the present application because it contains the chewing gum in the above-mentioned embodiments, can play a role in cleaning the oral cavity and preventing dental caries while meeting the smokers' cravings.
  • the magnolia bark raw material is dried and crushed, and 8 times the mass of ethanol is added to extract for 24 hours at room temperature, wherein the volume fraction of ethanol is 50%. After filtering the extract, add 8 times the ethanol solution to the residue and extract for 24 hours at room temperature and filter. The filtrate was then combined, and the filtrate was concentrated under reduced pressure, and then adsorbed on a macroporous resin.
  • the adsorbed macroporous resin is eluted three times with ethanol with a volume fraction of 85%, the eluate is collected, and the eluate is concentrated under reduced pressure, and then freeze-dried to obtain the Magnolia Bark extract.
  • the green tea raw materials are dried and pulverized, and 15 times the mass of ethanol is added to extract for 48 hours at room temperature, where the volume fraction of ethanol is 70%. After filtering the extract, add 15 times the ethanol solution to the residue and extract for 24 hours at room temperature, and then filter. The filtrate was then combined, and the filtrate was concentrated under reduced pressure, and then adsorbed on a macroporous resin.
  • the adsorbed macroporous resin is eluted with 75% ethanol with a volume fraction of 4 times, the eluate is collected, and the eluate is concentrated under reduced pressure, and then freeze-dried to obtain a green tea extract.
  • Example 2 The difference from Example 2 is that 2 g of limonene and 1 g of citral are replaced with 3 g of lemon extract.
  • Example 4 The difference from Example 4 is that 2 g of magnolia bark extract is used instead of 2 g of magnolol.
  • Example 6 The difference from Example 6 is that 3 g of limonene and 2 g of citral and 3 g of green tea extract are used to replace 3 g of tea polyphenols with 5 g of lemon extract.
  • Example 9 The difference from Example 9 is that 20 g of chewing gum provided in Example 3 is used instead of 20 g of chewing gum provided in Example 2.
  • Example 4 Mix 25 g of chewing gum provided in Example 4 with 2 g of nicotine salt, then add 25 g of propylene glycol, 45 g of glycerin, and 3 g of flavor II to mix uniformly, and obtain an electronic cigarette liquid after stirring.
  • Example 11 The difference from Example 11 is that 25 g of chewing gum provided in Example 5 is used instead of 25 g of chewing gum provided in Example 4.
  • Example 13 The difference from Example 13 is that 15 g of chewing gum provided in Example 7 is used instead of 15 g of chewing gum provided in Example 6.
  • composition of the fragrances in the foregoing Examples 9 to 15 is shown in Table 1 below.
  • Sample preparation The CORESTA (Cooperation Centre for Scientific Research Relative to Tobacco) standard (test document: ISO 20768:2018) is used to atomize the sample to generate aerosol through an atomizing device (electronic cigarette), and a Cambridge filter is used to collect the aerosol. Its aerosol absorption weight is 0.716g. Then put the Cambridge filter into a small beaker, then add 7.16 mL of 50% ethanol, and use ultrasonic extraction for 30 minutes to prepare an extraction solution with a concentration of 100 mg/mL. The extraction solution is diluted to obtain a test solution with a series of gradient concentrations (50, 25, 12.5, 6.25, 3.125, 1.562, 0.781 mg/mL).
  • Preparation of bacterial suspension Take out the preserved bacterial species: Streptococcus mutans (ATCC 25175) and Porphyromonas gingivalis (ATCC 33277) from the environment of -80°C, pick an appropriate amount of colonies from them, place them on the plate, and place them on the plate. Incubate at °C for 36h to activate. Then pick an appropriate amount of colonies from the plate and place them in another plate, incubate at 37°C for 36 hours, and repeat this step twice.
  • Streptococcus mutans ATCC 25175
  • Porphyromonas gingivalis ATCC 33277
  • Preparation of the medicated plate Take 1 mL of the test solution of different concentrations and add it to the petri dish, then add 9 mL of the culture medium to the petri dish and shake well. Prepare a series of gradient concentration (10, 5, 2.5, 1.25, 0.625, 0.3125, 0.1562, 0.0781mg/mL) drug plates, the sample solvent is a negative control, after pouring, place the petri dish horizontally to solidify the medium for use.
  • Bacterial inhibition assay Take 100 ⁇ L of bacterial suspension and spread it evenly on the medicated plate. Incubate it upside down at 37°C for 24 hours, observe the growth of the test bacteria, and record the minimum sample concentration that completely inhibits the growth of the bacteria as the Minimum Inhibitory Concentration (MIC).
  • MIC Minimum Inhibitory Concentration
  • Example 8 the chewing gum containing Magnolia Bark extract can more effectively inhibit bacteria and make its MIC as low as 0.1562 mg/mL.
  • this application provides a chewing gum and a method of use thereof.
  • the chewing gum can be passed through an atomizing device to generate an aerosol for the user to inhale, and the chewing gum aerosol can be sucked into the mouth. Clean the mouth, prevent dental caries, etc.
  • the present application provides an electronic cigarette liquid containing the chewing gum, which is inhaled by the user after being atomized by an atomizer, and the chewing gum is also inhaled into the mouth of the mist, and at the same time, it can clean the oral cavity and prevent dental caries.

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Abstract

一种口香糖、电子烟液及其用途。口香糖包含10-50重量份的甜味剂、5-20重量份的凉味剂及15-85重量份的丙二醇；甜味剂包含木糖醇、麦芽糖、甜菊糖、鼠李糖、海藻糖、赤藓糖醇、乳糖和半乳糖中的至少一种。该口香糖可通过电子烟、超声雾化器等各种雾化器入口，应用于电子烟中可具有清洁口腔、预防龋齿的作用。

Description

口香糖、电子烟液及其用途 技术领域
本申请涉及电子气雾剂或电子雾化装置的领域，尤其涉及一种口香糖及其在雾化装置中的应用。
背景技术
传统的口香糖是以天然树胶或甘油树脂为胶体的基础，加入糖浆、薄荷、甜味剂等调和压制而成的一种供使用者放入口中嚼咬的糖。可分为板式口香糖、泡泡糖和糖衣口香糖三种。口香糖能够清洁口腔，提升口腔健康，但其残渣主要成份是胶基，胶基属于高分子物质，难降解，不被人体吸收，粘在地上、地毯上很难被清理，而且容易粘染灰尘和细菌，污染环境；如果不慎被儿童吞咽，容易发生危险；且长时间咀嚼会对脸部产生负面影响。
因此，提供一种可解决上述问题的口香糖及其在雾化装置中的使用方法。
发明内容
本申请通过提供一种不含有胶体的口香糖及其使用方法，该口香糖不含传统口香糖中的胶基，其成分均是易降解、可食用的，无传统口香糖中的胶基残渣，没有难清理和污染环境的问题，无需咀嚼，不会对脸部产生负面影响。该口香糖能通过雾化装置产生可供使用者吸入的气雾，并起到清洁口腔，预防龋齿的作用。
根据本申请的一个层面，本申请提供了一种口香糖，其包含以下重量份的物质：10至50份的甜味剂、5至20份的凉味剂及15至85份的丙二醇；其中所述甜味剂包括木糖醇、麦芽糖、甜菊糖、鼠李糖、海藻糖、赤藓糖醇、乳糖和半乳糖中的至少一种。
根据本申请的另一层面，本申请提供了一种电子烟液，其包含上述口香糖。
根据本申请的另一层面，本申请提供了一种雾化装置，其包含上述口香糖或电子烟液。
根据本申请的另一层面，本申请提供了一种上述的口香糖或电子烟液的使用方法，其中所述口香糖或电子烟液可通过雾化装置雾化生成供使用者吸入的气雾。本申请的口香糖或电子烟液可以起到清洁口腔或预防龋齿的作用。
本申请实施例的额外层面及优点将部分地在后续说明中描述、显示、或是经由本申请实施例的实施而阐释。
具体实施方式
本申请的实施例将会被详细的描示在下文中。本申请的实施例不应所述被解释为对本申请的限制。
另外，有时在本文中以范围格式呈现量、比率和其它数值。应理解，此类范围格式是用于便利及简洁起见，且应灵活地理解，不仅包含明确地指定为范围限制的数值，而且包含涵盖于所述范围内的所有个别数值或子范围，如同明确地指定每一数值及子范围一般。
如本文中所使用，术语“大致”、“大体”、“大体上”、“实质”及“约”用以描述及说明小的变化。当与事件或情形结合使用时，所述术语可指代其中事件或情形精确发生的例子以及其中事件或情形极近似地发生的例子。举例来说，当结合数值使用时，术语可指代小于或等于所述数值的±10％的变化范围，例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％。举例来说，如果两个数值之间的差值小于或等于所述值的平均值的±10％(例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％)，那么可认为所述两个数值“大体上”相同。
在具体实施方式及权利要求书中，由术语“中的至少一者”、“中的至少一个”、“中的至少一种”或其他相似术语所连接的项目的列表可意味着所列项目的任何组合。例如，如果列出项目A及B，那么短语“A及B中的至少一者”意味着仅A；仅B；或A及B。在另一实例中，如果列出项目A、B及C，那么短语“A、B及C中的至少一者”意味着仅A；或仅B；仅C；A及B(排除C)；A及C(排除B)；B及C(排除A)；或A、B及C的全部。项目A可包含单个元件或多个元件。项目B可包含单个元件或多个元件。项目C可包含单个元件或多个元件。
在本文中，用语“用于使用者吸入的气雾”可以包括，但不限于，气溶胶、悬浮液体、低温蒸气及挥发性气体。
本申请提供一种口香糖及其使用方法，供使用者用更简单更环保的方法吸入雾化后的口香糖，起到清洁口腔的作用。同时，本申请提供一种口香糖在电子烟中的应用，使用者在吸食电子烟的同时可以起到清洁口腔，预防龋齿的作用。
根据本申请的一个层面，本申请提供了一种口香糖，所述口香糖包含以下重量份的物质：约10至约50份的甜味剂、约5至约20份的凉味剂及约15至约85份的丙二醇。
在一些实施例中，甜味剂在口香糖中的重量份大致为，例如，10份、15份、20份、25份、30份、35份、40份、45份、50份或这些份数中任意两者组成的范围。在一些实施例中，凉味剂在口香糖中的重量份大致为，例如，5份、10份、15份、20份或这些份数中任意两者组成的范围。在一些实施例中，丙二醇在口香糖中的重量份大致为，例如，15份、20份、25份、30份、35份、40份、45份、50份、55份、60份、65份、70份、75份、80份、85份或这些份数中任意两者组成的范围。
甜味剂为添加剂，其能够使产品在使用时让使用者产生甜味的感受。甜味剂按制备方法可分为人工合成甜味剂和天然甜味剂。人工甜味剂的实例包含，但不限于，糖精钠、甜蜜素、阿斯巴甜、安赛蜜。天然甜味剂的实例包含，但不限于，木糖醇、麦芽糖、甜菊糖、鼠李糖、海藻糖、赤藓糖醇、乳糖。
在一些实施例中，所述甜味剂为天然甜味剂，其包括选自由木糖醇、麦芽糖、甜菊糖、鼠李糖、海藻糖、赤藓糖醇、乳糖和、半乳糖及其组合所组成的群组。在另一些实施例中，所述甜味剂为木糖醇。本申请口香糖通过其添加的木糖醇，可达到清洁口腔的效果。
凉味剂为添加剂，其为能够使产品在使用时让使用者产生清凉效果的感受且刺激性不强的化学物。在一些实施例中，所述凉味剂包括选自由薄荷脑、薄荷酮、异薄荷酮、乳酸薄荷酯、WS-23(N,2,3-三甲基-2-异丙基丁酰胺)、WS-3(N-乙基-对薄荷基-3-甲酰胺)、WS-5(N-(乙氧羰基甲基)-对烷-3-甲酰胺)、WS-12(N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺)、乙酸薄荷酯及其组合所组成的群组。
在一些实施例中，所述口香糖还包含以下重量份的物质：约0至约15份的中药组合物。在一些实施例中，中药组合物在口香糖中的重量份大致约为，例如，1份、2份、3份、4份、5份、10份、15份或这些份数中任意两者组成的范围。
所述中药组合物包括柠檬提取物、厚朴提取物、绿茶提取物中的一种或多种，其中所述柠檬提取物包含柠檬烯、柠檬醛及芳樟醇中的至少一种，所述厚朴提取物包含厚朴酚及和厚朴酚中的至少一种，且所述绿茶提取物包含茶多酚及咖啡碱中的至少一种。在一些实施例中，所述中药组合物包括厚朴酚。
柠檬提取物具有抑菌、清除自由基的作用。厚朴提取物抑菌、清除自由基、消痰止咳等作用。绿茶提取物具有抗氧化等作用。本申请口香糖通过其添加的中药组合物，可达到清洁口腔、预防龋齿等作用的效果。
在一些实施例中，所述柠檬提取物为采用水蒸气蒸馏法提取获得。具体的，所述水蒸气蒸馏法包含以下步骤：将柠檬或薄荷原料分别加入蒸馏瓶中，加入约8至约15倍质量的纯水，加热蒸馏提取约3小时至约6小时，收集蒸馏液以获得柠檬提取物。在一些实施例中，柠檬可以是新鲜的，也可以是干燥(例如阴干)的。
在一些实施例中，所述厚朴提取物和所述绿茶提取物为采用有机溶剂提取法获得，所述提取用的有机溶剂为乙醇的体积分数为约40％至约80％。具体的，所述有机溶剂提取法包含以下步骤：
(1)将厚朴或绿茶原料干燥后粉碎，加入约8至约15倍质量的乙醇在常温下提取约16小时至约72小时，其中乙醇的体积分数为约40％至约80％。对提取液过滤，过滤后，将残渣再加入约8至约15倍质量的乙醇溶液在常温下提取约12小时至约48小时，过滤。
(2)随后合并滤液，将滤液减压浓缩后，以大孔树脂吸附。使用体积分数为约70％至约90％的乙醇多次对吸附后的大孔树脂洗脱，收集洗脱液，将洗脱液减压浓缩后，再经冷冻干燥，即可得厚朴或绿茶提取物。
在一些实施例中，在步骤(1)中，厚朴提取物使用体积分数为约40％至约60％的乙醇提取，绿茶提取物使用体积分数为约70％至约80％的乙醇提取。
在一些实施例中，在步骤(2)中，对大孔树脂洗脱时，厚朴提取物使用体积分数约80％至约90％的乙醇洗脱；绿茶提取物使用体积分数约70％至约80％的乙醇洗脱。
在一些实施例中，大孔树脂为D-101型非极性树脂。
在一些实施例中，在步骤(2)中冷冻干燥的工艺条件为：预冷冻温度为约-20℃至约-50℃，预冷冻时间为约15小时至约30小时，冷冻干燥温度在约-40℃至约20℃程序升温，冷冻干燥时间为约24小时至约72小时，并在约4Pa至约107Pa的压力下进行冷冻干燥。
根据本申请的另一个层面，所述口香糖还包含以下重量份的物质：约0至约15份的风味成分，其中所述风味成分包括柠檬烯、柠檬醛、芳樟醇、厚朴酚、茶多酚及咖啡碱中的至少一种。本申请口香糖通过其添加的风味成分，可提升抑菌效果并在使用时达到清洁口腔的效果。
在一些实施例中，上述口香糖能够进一步包含约0.01至约25重量份的香精。在一些实施例中，所述香精在口香糖中的重量份含量为，例如，0.01份、0.05份、0.1份、0.25份、0.5份、1份、5份、10份、15份、20份、25份或这些份数中任意两者组成的范围。
香精为本领域中任一可用于电子烟液中的香精，例如，但不限于，西瓜口味、绿茶口味香精。在一些实施例中，所述香精包含选自由α-蒎烯、苯甲醇、苯甲醛、苯乙醛、苯甲酸苄酯、橙花醛、橙花醇、香叶醇、吲哚、茉莉酮、橙花叔醇、杨梅醛、二氢茉莉酮酸甲酯、二氢猕猴桃内脂、丁香酚、β-月桂烯、伞花烃、癸二酸二乙酯、2-甲基丁酸甲酯、2-甲基丁酸乙酯、异戊酸乙酯、γ-松油烯、γ-松油醇、γ-己内酯、γ-辛内酯、γ-癸内酯、γ-辛丁酯、γ-十一内酯、γ-十二内酯、叶醇、己醇、戊醇、2，5-二甲基吡嗪、桂酸甲酯、桂酸乙酯、乙基麦芽酚、异戊酸乙酯、甜瓜醛、香兰素、甲基庚烯酮、麦芽酚、乙基麦芽酚、乙酸2-甲基丁酯、乙酸乙酯、乙酸丁酯、乙酸异戊酯、乙酸己酯、乙酸叶醇酯、丙酸、丙酸乙酯、丁酸乙酯、2-甲基丁酸乙酯、麦斯明、三醋酸甘油酯、芳樟醇氧化物、苯乙醇、氧代异佛尔酮、顺-6-壬烯醇及其组合所组成的群组。
本领域技术人员应理解，本申请实施例的口香糖可以根据实际制备需求选择任何合适的已知方法制造，而不受其限制。
根据本申请的另一个层面，本申请提供了一种电子烟液，所述电子烟液包含上述实施例中的口香糖。
在一些实施例中，所述电子烟液包含以下重量份的物质：约0.5至约20份的甜味剂、约0.25至约8份的凉味剂、约0至约6份的风味成分或中药组合物、约0至约5份的尼古丁盐、约30至约60份的甘油及约10至约65份的丙二醇；其中所述风味成分包括柠檬烯、柠檬醛、芳樟醇、厚朴酚、茶多酚及咖啡碱中的至少一种，所述中药组合物包括柠檬提取物、厚朴提取物和绿茶提取物中的至少一种。在一些实施例中，所述尼古丁盐在电子烟液中的重量份含量为，例如，0份、0.5份、1份、1.5份、2份、2.5份、3份、4份、5份。
应理解，本领域技术人员可根据实际需求选用本领域中任何已知的尼古丁盐加入电子 烟液中，而不受其限制。在一些实施例中，所述尼古丁盐包含苯甲酸盐。
在一些实施例中，所述电子烟液能够进一步包含约0.01至约10重量份的香精。在一些实施例中，所述香精在口香糖中的重量份含量为，例如，0.01份、0.05份、0.1份、0.25份、0.5份、1份、5份、10份或这些份数中任意两者组成的范围。
香精为本领域中任一可用于电子烟液中的香精，例如，但不限于，西瓜口味、绿茶口味香精。在一些实施例中，所述香精包含选自由α-蒎烯、苯甲醇、苯甲醛、苯乙醛、苯甲酸苄酯、橙花醛、橙花醇、香叶醇、吲哚、茉莉酮、橙花叔醇、杨梅醛、二氢茉莉酮酸甲酯、二氢猕猴桃内脂、丁香酚、β-月桂烯、伞花烃、癸二酸二乙酯、2-甲基丁酸甲酯、2-甲基丁酸乙酯、异戊酸乙酯、γ-松油烯、γ-松油醇、γ-己内酯、γ-辛内酯、γ-癸内酯、γ-辛丁酯、γ-十一内酯、γ-十二内酯、叶醇、己醇、戊醇、2，5-二甲基吡嗪、桂酸甲酯、桂酸乙酯、乙基麦芽酚、异戊酸乙酯、甜瓜醛、香兰素、甲基庚烯酮、麦芽酚、乙基麦芽酚、乙酸2-甲基丁酯、乙酸乙酯、乙酸丁酯、乙酸异戊酯、乙酸己酯、乙酸叶醇酯、丙酸、丙酸乙酯、丁酸乙酯、2-甲基丁酸乙酯、麦斯明、三醋酸甘油酯、芳樟醇氧化物、苯乙醇、氧代异佛尔酮、顺-6-壬烯醇及其组合所组成的群组。
根据本申请一些实施例，本申请提供电子烟液的制备方法，其包含以下步骤：将尼古丁盐和口香糖分别配制好，然后按实施例提供的范围中的特定比例混合，随后加入香精、尼古丁盐，然后加入丙二醇和甘油，使其均匀混合以获得电子烟液。
根据本申请的另一个层面，本申请提供了一种雾化装置，其中所述雾化装置包含上述实施例中的口香糖或电子烟液。所述口香糖或所述电子烟液可通过所述雾化装置雾化生成供使用者吸入的气雾。
在一些实施例中，所述雾化装置包括电子烟、超声雾化器或网式雾化器。
本申请实施例提供的电子烟液，由于含有上述实施例中的口香糖，可以在满足吸烟者对烟瘾需求的同时起到清洁口腔、预防龋齿的作用。
实施例
为便于更好地理解本申请，通过以下实例加以说明。这些实例属于本申请的保护范围，但不限制本申请的保护范围。
柠檬提取物的制备
将干燥的柠檬原料及干燥的薄荷原料分别加入蒸馏瓶中，加入12倍质量的纯水， 加热蒸馏提取5小时，收集蒸馏液即获得柠檬提取物。
厚朴提取物或绿茶提取物的制备
将厚朴原料干燥后粉碎，加入8倍质量的乙醇在常温下提取24小时，其中乙醇的体积分数为50％。对提取液过滤，过滤后，将残渣再加入8倍的乙醇溶液在常温下提取24小时，过滤。随后合并滤液，将滤液减压浓缩后，以大孔树脂吸附。使用体积分数为85％的乙醇对吸附后的大孔树脂洗脱3次，收集洗脱液，将洗脱液减压浓缩后，再经冷冻干燥，即可得厚朴提取物。
将绿茶原料干燥后粉碎，加入15倍质量的乙醇在常温下提取48小时，其中乙醇的体积分数为70％。对提取液过滤，过滤后，将残渣再加入15倍的乙醇溶液在常温下提取24小时，过滤。随后合并滤液，将滤液减压浓缩后，以大孔树脂吸附。使用体积分数为75％的乙醇对吸附后的大孔树脂洗脱4次，收集洗脱液，将洗脱液减压浓缩后，再经冷冻干燥，即可得绿茶提取物。
口香糖:
实施例1
将30g木糖醇、13g薄荷脑及54g丙二醇混合，搅拌均匀，得到口香糖。
实施例2
将30g木糖醇、13g薄荷脑、2g柠檬烯、1g柠檬醛及54g丙二醇混合，搅拌均匀，得到口香糖。
实施例3
与实施例2的区别在于用3g柠檬提取物替换2g柠檬烯和1g柠檬醛。
实施例4
将20g木糖醇、10g赤藓糖醇、4g薄荷脑、5gWS-23、2g厚朴酚及59g丙二醇混合，搅拌均匀，得到口香糖。
实施例5
与实施例4的区别在于用2g厚朴提取物替换2g厚朴酚。
实施例6
将5g木糖醇、10g麦芽糖、5g海藻糖、5g乳糖、5g薄荷脑、10g WS-3、3g柠檬烯、 2g柠檬醛、3g茶多酚及52g丙二醇混合，搅拌均匀，得到口香糖。
实施例7
与实施例6的区别在于用5g柠檬提取物替换3g柠檬烯和2g柠檬醛及3g绿茶提取物替换3g茶多酚。
实施例8
将10g甜菊糖、8g鼠李糖、8g半乳糖、3.5gWS-3、5g乙酸薄荷酯、2g柠檬烯、3g厚朴酚、5g茶多酚及51g丙二醇混合，搅拌均匀，得到口香糖。
包含口香糖的电子烟液:
实施例9
将实施例2提供的20g口香糖与3g尼古丁盐混合，随后加入24g丙二醇、50g甘油及3g香精I均匀混合，搅拌后获得电子烟液。
实施例10
与实施例9的区别在于用实施例3提供的20g口香糖替换实施例2提供的20g口香糖。
实施例11
将实施例4提供的25g口香糖与2g尼古丁盐混合，随后加入25g丙二醇、45g甘油及3g香精II均匀混合，搅拌后获得电子烟液。
实施例12
与实施例11的区别在于用实施例5提供的25g口香糖替换实施例4提供的25g口香糖。
实施例13
将实施例6提供的15g口香糖与5g尼古丁盐混合，随后加入20g丙二醇、55g甘油及5g香精III均匀混合，搅拌后获得电子烟液。
实施例14
与实施例13的区别在于用实施例7提供的15g口香糖替换实施例6提供的15g口香糖。
实施例15
将实施例8提供的30g口香糖与4g苯甲酸尼古丁盐混合，随后加入21g丙二醇、40g甘油及5g香精IV均匀混合，搅拌后获得电子烟液。
实施例16
将1g实施例4提供的口香糖与2g尼古丁盐混合，随后加入47g丙二醇及50g甘油均匀混合，搅拌后获得电子烟液。
上述实施例9至15中各香精的组成如下表1所示。
表1
Figure PCTCN2019108302-appb-000001
Figure PCTCN2019108302-appb-000002
上述实施例1-8的口香糖及实施例9-16的电子烟液完成后，随后进行细菌抑制测试。
细菌抑制测试方式；
样品制备：采用CORESTA(Cooperation Centre for Scientific Research Relative to Tobacco)标准(测试文献：ISO 20768:2018)通过雾化装置(电子烟)将样品雾化生成气雾，并采用剑桥滤片收集气雾，其吸收气雾重量为0.716g。随后将剑桥滤片放入小烧杯中，然后加入7.16mL的50％乙醇，采用超声提取30mins，配成浓度为100mg/mL的萃取溶液。将萃取溶液稀释以获得成系列梯度浓度(50、25、12.5、6.25、3.125、1.562、0.781mg/mL)的测试溶液。
菌悬液的制备：从－80℃环境中取出保存的菌种：变异链球菌(ATCC 25175)和牙龈卟啉单胞菌(ATCC 33277)，从中挑取适量菌落置于平板上，并在37℃下培养36h活化。随后从平板上挑取适量菌落置于另一平板中，在37℃下培养36h，并重复该步骤2次。
用接种环挑取适量菌种于离心管中，充分振摇，稀释以获得10 5至10 6CFU/mL的菌悬液。
带药平板的制备：取不同浓度的测试溶液1mL,加入培养皿中，再在培养皿中加入9mL的培养基，摇匀。配制成系列梯度浓度(10、5、2.5、1.25、0.625、0.3125、0.1562、0.0781mg/mL)的药物平板，样品溶剂为阴性对照，倒完后水平放置培养皿，使培养基凝固，备用。
细菌抑制测定：取100μL菌悬液加在带药平板上均匀涂开。在37℃中倒置培养24h，观察供试菌生长情况，并记录完全抑制细菌生长的最低样品浓度为对供试菌的最小抑制浓度(Minimum Inhibitory Concentration，MIC)。
实施例1-8的口香糖及实施例9-16的电子烟液经过细菌抑制测试的测试结果如下表2所示。
表2
Figure PCTCN2019108302-appb-000003
Figure PCTCN2019108302-appb-000004
由表1中数据可知，本申请实施例1-8的口香糖及实施例9-16的电子烟液经雾化、稀释后仍然能有效的抑制细菌的生长，以达到清洁口腔、预防龋齿等作用。相较于实施例16，实施例9-15的电子烟液中的口香糖组成在本申请实施例提供的浓度范围内，其抑菌效果更加明显。
此外，通过比较实施例1与实施例2-8的口香糖的抑菌测试结果可知，添加了风味成份或中药组合物的实施例，其抗菌效果有更显著的提升。举例而言，在实施例8中，口香糖包含厚朴提取物可以更有效的抑制细菌并使其MIC低至0.1562mg/mL。
通过本申请上述实施例应可了解，本申请提供了一种口香糖及其使用方法，所述口香糖能通过雾化装置以产生供使用者吸入的气雾，将口香糖气雾吸入口中，能起到清洁口腔、预防龋齿等作用。此外，本申请提供一种包含该口香糖的电子烟液，其经过雾化器雾化后由使用者吸入，也将口香糖吸气雾入口中，同时起到清洁口腔、预防龋齿等作用。
虽然已参考本申请的特定实施例描述并说明本申请，但是这些描述和说明并不限制本申请。所属领域的技术人员可清晰地理解，在不脱离如由所附权利要求书定义的本申请的真实精神和范围的情况下，可进行各种改变，以使特定情形、材料、物质组成、物质、方法或过程适宜于本申请的目标、精神和范围。所有此类修改都意图在此所附权利要求书的范围内。虽然已参考按特定次序执行的特定操作描述本文中所公开的方法，但 应理解，可在不脱离本申请的教示的情况下组合、细分或重新排序这些操作以形成等效方法。因此，除非本文中特别指示，否则操作的次序和分组并非本申请的限制。
前文概述本申请的若干实施例及细节方面的特征。本申请中描述的实施例可容易地用作用于设计或修改其它过程的基础以及用于执行相同或相似目的和/或获得引入本文中的实施例的相同或相似优点的结构。此类等效构造并不脱离本申请的精神和范围，并且可在不脱离本申请的精神和范围的情况下作出各种改变、替代和变化。

Claims (13)

  1. 一种口香糖，其包含以下重量份的物质：
    10至50份的甜味剂、5至20份的凉味剂及15至85份的丙二醇；其中所述甜味剂包括木糖醇、麦芽糖、甜菊糖、鼠李糖、海藻糖、赤藓糖醇、乳糖和半乳糖中的至少一种。
  2. 根据权利要求1所述的口香糖，其中所述甜味剂包括木糖醇。
  3. 根据权利要求1或2所述的口香糖，其进一步包括0至15重量份的风味成分或中药组合物；其中所述风味成分包括柠檬烯、柠檬醛、芳樟醇、厚朴酚、茶多酚及咖啡碱中的至少一种，以及所述中药组合物包括柠檬提取物、厚朴提取物和绿茶提取物中的至少一种。
  4. 根据权利要求1或2所述的口香糖，其中所述凉味剂包括薄荷脑、薄荷酮、异薄荷酮、乳酸薄荷酯、N,2,3-三甲基-2-异丙基丁酰胺、N-乙基-对薄荷基-3-甲酰胺、N-(乙氧羰基甲基)-对烷-3-甲酰胺、N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺和乙酸薄荷酯中的至少一种。
  5. 根据权利要求1或2所述的口香糖，其进一步包括：0.01至25重量份的香精。
  6. 根据权利要求5所述的口香糖，其中所述香精选自由α-蒎烯、苯甲醇、苯甲醛、苯乙醛、苯甲酸苄酯、橙花醛、橙花醇、香叶醇、吲哚、茉莉酮、橙花叔醇、杨梅醛、二氢茉莉酮酸甲酯、二氢猕猴桃内脂、丁香酚、β-月桂烯、伞花烃、癸二酸二乙酯、2-甲基丁酸甲酯、2-甲基丁酸乙酯、异戊酸乙酯、γ-松油烯、γ-松油醇、γ-己内酯、γ-辛内酯、γ-癸内酯、γ-辛丁酯、γ-十一内酯、γ-十二内酯、叶醇、己醇、戊醇、2，5-二甲基吡嗪、桂酸甲酯、桂酸乙酯、乙基麦芽酚、异戊酸乙酯、甜瓜醛、香兰素、甲基庚烯酮、麦芽酚、乙基麦芽酚、乙酸2-甲基丁酯、乙酸乙酯、乙酸丁酯、乙酸异戊酯、乙酸己酯、乙酸叶醇酯、丙酸、丙酸乙酯、丁酸乙酯、2-甲基丁酸乙酯、麦斯明、三醋酸甘油酯、芳樟醇氧化物、苯乙醇、氧代异佛尔酮、顺-6-壬烯醇及其组合所组成的群组。
  7. 一种电子烟液，其包含权利要求1至6中任一权利要求所述的口香糖。
  8. 根据权利要求7所述的电子烟液，其包含以下重量份的物质：0.5至20份的甜味剂、0.25至8份的凉味剂、0至6份的风味成分或中药组合物、0至5份的尼古丁盐、30至60份的甘油及10至65份的丙二醇；其中所述风味成分包括柠檬烯、柠檬醛、芳樟醇、厚朴酚、茶多酚及咖啡碱中的至少一种，以及所述中药组合物包括柠檬提取物、厚 朴提取物和绿茶提取物中的至少一种。
  9. 根据权利要求8所述的电子烟液，其进一步包括：0.01至10重量份的香精。
  10. 根据权利要求9所述的电子烟液，其中所述香精选自由α-蒎烯、苯甲醇、苯甲醛、苯乙醛、苯甲酸苄酯、橙花醛、橙花醇、香叶醇、吲哚、茉莉酮、橙花叔醇、杨梅醛、二氢茉莉酮酸甲酯、二氢猕猴桃内脂、丁香酚、β-月桂烯、伞花烃、癸二酸二乙酯、2-甲基丁酸甲酯、2-甲基丁酸乙酯、异戊酸乙酯、γ-松油烯、γ-松油醇、γ-己内酯、γ-辛内酯、γ-癸内酯、γ-辛丁酯、γ-十一内酯、γ-十二内酯、叶醇、己醇、戊醇、2，5-二甲基吡嗪、桂酸甲酯、桂酸乙酯、乙基麦芽酚、异戊酸乙酯、甜瓜醛、香兰素、甲基庚烯酮、麦芽酚、乙基麦芽酚、乙酸2-甲基丁酯、乙酸乙酯、乙酸丁酯、乙酸异戊酯、乙酸己酯、乙酸叶醇酯、丙酸、丙酸乙酯、丁酸乙酯、2-甲基丁酸乙酯、麦斯明、三醋酸甘油酯、芳樟醇氧化物、苯乙醇、氧代异佛尔酮、顺-6-壬烯醇及其组合所组成的群组。
  11. 一种雾化装置，其包含权利要求1至6中任一权利要求所述的口香糖或权利要求7或8所述的电子烟液。
  12. 根据权利要求9所述的雾化装置，其中所述雾化装置包括电子烟、超声雾化器或网式雾化器。
  13. 一种根据权利要求1至6中任一权利要求所述的口香糖或权利要求7或8所述的电子烟液在清洁口腔或预防龋齿中的用途。
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