WO2020197145A1 - Dispositif de fabrication de capsule molle - Google Patents

Dispositif de fabrication de capsule molle Download PDF

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Publication number
WO2020197145A1
WO2020197145A1 PCT/KR2020/003624 KR2020003624W WO2020197145A1 WO 2020197145 A1 WO2020197145 A1 WO 2020197145A1 KR 2020003624 W KR2020003624 W KR 2020003624W WO 2020197145 A1 WO2020197145 A1 WO 2020197145A1
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WO
WIPO (PCT)
Prior art keywords
capsule
film
chemical liquid
injection nozzle
chemical
Prior art date
Application number
PCT/KR2020/003624
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English (en)
Korean (ko)
Inventor
강원호
Original Assignee
유엠에스엔지니어링 주식회사
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Publication date
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Publication of WO2020197145A1 publication Critical patent/WO2020197145A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S53/00—Package making
    • Y10S53/90—Capsules

Definitions

  • the present invention relates to a soft capsule manufacturing apparatus, and more particularly, to a soft capsule manufacturing apparatus for manufacturing a soft capsule containing a tablet and a chemical solution.
  • Capsule-type drugs can also be manufactured in various forms, as long as there is a capsule-type drug that is a capsule only in appearance and is filled with powder inside (in this case, the capsule is separated by pulling by holding both sides of the capsule to expose the powder filled inside), inside There are also drugs that are filled with tablets and liquids, wrapped in a film, and manufactured in the form of soft capsules. In addition, various types of drugs are being manufactured. Hereinafter, a description will be made focusing on a soft capsule manufacturing apparatus for manufacturing the latter type of soft capsule.
  • Korean Patent Registration No. 10-1694749 discloses a'soft capsule manufacturing apparatus containing a solid dosage form'.
  • a unit that thermocompresses and cuts both sides of the gelatin sheet to form a soft capsule contains a solid dosage form consisting of the contents. It provides a soft capsule manufacturing device.
  • tablets are supplied through the right die-roll outer circumferential decompression surface 402. If the outer circumferential surface is decompressed on the right die-roll outer circumferential decompression surface 402 in advance as described above, the gelatin sheet is formed on the right die roll outer circumferential decompression surface 402 In a state in close contact with the wedge segment adhesive surface 803 is met and brought into contact.
  • the gelatin sheet is kept in close contact with the pressure-sensitive surface 402 on the outer periphery of the die roll on the right side, but the gelatin sheet existing between the pressure-sensitive surface 402 and the pressure-sensitive surface 402 is irregularly drawn to the pressure-sensitive surface 402. As it enters, it has irregular expansion elasticity. Therefore, there is a problem in that the shape of the capsule of the final product has a shape that does not correspond to the shape of the pressure-sensitive surface 402. In addition, there is a problem that the thickness of the irregular gelatin sheet caused by the irregular expansion elasticity affects the mass of the injected contents.
  • the present invention provides an apparatus for manufacturing a soft capsule having a structure capable of manufacturing a cross section based on a junction line of a soft capsule containing a tablet and a drug solution to match the shape of the pressure reducing surface of the capsule groove formed on the die roll.
  • the soft capsule manufacturing apparatus supplies the first film with the first film wound on at least one surface, and a plurality of first capsule grooves are formed along the outer circumferential surface.
  • 1 die roll A second die roll disposed adjacent to the first die roll, supplying the second film with a second film wound on at least one surface thereof, and having a plurality of second capsule grooves formed along an outer circumferential surface thereof;
  • a wedge installed in close contact with the first film and the second film wound on one surface of the first die roll and the second die roll;
  • a depressurization unit for depressurizing the first capsule groove or the second capsule groove so that the first film or the second film is in close contact with the inner surface;
  • a tablet supply unit for supplying tablets to the first capsule groove or the second capsule groove;
  • a chemical liquid injection nozzle for injecting a chemical liquid into the first capsule groove and the second capsule groove to form a soft capsule, wherein at least one of the chemical liquid injection nozzles is an inside of the first capsule groove or the second capsule groove by
  • a chemical liquid discharge part for discharging the circulated internal air or a chemical liquid mixed with air may be installed around the chemical liquid injection nozzle.
  • the chemical liquid discharge part may be disposed symmetrically to the chemical liquid injection nozzle with respect to a center line of the first capsule groove or the second capsule groove.
  • a separation filter may be installed at an inlet of the chemical liquid discharge part to discharge only the chemical liquid and prevent the tablet from passing through.
  • the first capsule groove may be formed such that a corner portion where a bottom surface and a side wall meet to form a curved surface.
  • the chemical liquid injection nozzle includes: a first chemical liquid injection nozzle for injecting a chemical liquid into the first capsule groove so that the first film is concaved by the amount of the chemical liquid; And a second chemical solution injection nozzle for injecting a chemical solution into the second film in close contact with the inner surface of the second capsule groove.
  • the first chemical injection nozzle may be installed through the center of the wedge.
  • the second chemical solution injection nozzle is disposed eccentrically with respect to the center line of the second capsule groove, and may circulate the air and the chemical solution inside the second capsule groove by the injection force.
  • a chemical liquid discharge part through which the circulated internal air or a chemical liquid mixed with air is discharged may be installed around the second chemical liquid injection nozzle.
  • the second chemical solution injection nozzle and the chemical solution discharge part may be installed through the wedge, and the second chemical solution injection nozzle and the chemical solution discharge part may be configured as a set, and a plurality of sets may be installed along the length direction of the wedge.
  • the second chemical liquid injection nozzle and the chemical liquid discharge part may be installed through the wedge, and the second chemical liquid injection nozzle and the chemical liquid discharge part may each be composed of at least one or more, and may be disposed along the length direction of the wedge.
  • One of the second chemical liquid injection nozzles and the two chemical liquid discharge parts, or the two second chemical liquid injection nozzles and the one chemical liquid discharge part may be configured and disposed as a set.
  • a soft capsule including a tablet and a chemical solution can be manufactured in a desired shape, thereby improving the reliability of the final manufactured product.
  • the chemical liquid can always be injected in an appropriate amount.
  • FIG. 1 is a view of a soft capsule manufacturing apparatus according to an embodiment of the present invention.
  • Figure 2 is a view showing that the tablet is supplied to the second capsule groove.
  • FIG 3 is a view showing the injection of a chemical solution into a first film from a first chemical solution injection nozzle.
  • FIG. 4 is a view showing a difference in capacity of a chemical solution injected into a first film.
  • FIG. 5 is a view showing another embodiment of the first capsule groove.
  • FIG. 6 is a view showing a second chemical liquid injection nozzle and a chemical liquid discharge part formed in the wedge.
  • FIG. 7 is a view showing another embodiment of a second chemical solution injection nozzle and a chemical solution discharge unit.
  • FIG. 8 is a view showing that air or a chemical liquid mixed with air is circulated in a second capsule groove.
  • first and second may be used to describe various components, but the components should not be limited by the terms. These terms are used only for the purpose of distinguishing one component from another component.
  • FIG. 1 is a view of an apparatus for manufacturing a soft capsule according to an embodiment of the present invention
  • FIG. 2 is a view showing that tablets are supplied to a second capsule groove.
  • the first film 2 is supplied with the first film 2 wound on at least one surface, and a plurality of first films are supplied along the outer circumferential surface.
  • a second die roll 20 is formed;
  • a wedge 30 installed in close contact with the first film 2 and the second film 4 wound on one surface of the first die roll 10 and the second die roll 20;
  • a decompression unit 24 for decompressing the second capsule groove 22 after the second film 4 is in close contact with the wedge 30 so that the second film 4 is in close contact with the inner surface;
  • a tablet supply unit 32 installed in the wedge 30 to supply tablets 40 to the second capsule groove 22;
  • it may include a chemical liquid injection nozzles (34, 35) for injecting a chemical liquid into the first capsule groove 12 and the second capsule groove 22 to form the soft capsule 50.
  • the first film 2 and the second film 4 are supplied from the left and the right, respectively, and are supplied after being cooled in advance in a cooling drum (not shown) disposed on the left and right, respectively.
  • the first film 2 and the second film 4 are made of gelatin or an edible polymer material, and are parts that form an outer film when the soft capsule 50 is manufactured.
  • the first film 2 and the second film 4 are supplied to be wound on at least one surface of a pair of die rolls 10 and 20 disposed on the left and right sides, respectively.
  • the first film 2 and the second film 4 may be supplied to upper ends of the first die roll 10 and the second die roll 20.
  • the films 2 and 4 supplied to the upper ends of the die rolls 10 and 20 are in close contact with the lower surfaces of the wedges 30 disposed thereon.
  • a plurality of capsule grooves 12 and 22 are formed along the outer circumferential surface of the pair of die rolls 10 and 20 at regular center angle intervals.
  • the capsule grooves 12 and 22 are formed to be concave in order to form the film 2 and 4 into a soft capsule 50 shape.
  • a plurality of capsule grooves 12 and 22 are formed at regular intervals along the longitudinal direction of the die rolls 10 and 20. That is, the capsule grooves 12 and 22 are formed by being arranged in a plurality of columns and rows along the outer circumferential surfaces of the die rolls 10 and 20.
  • Each of the decompression units 24 is connected to one side of the inner surface of the second capsule groove 22 to be formed.
  • the depressurization unit 24 is a portion for forming a negative pressure inside the second capsule groove 22 so that the second film 4 is in close contact with the inner surface of the second capsule groove 22, and the second die roll 20 It may be formed to penetrate inside in a radial direction.
  • Equipment for depressurization such as a pump (not shown), may be connected to an end of the depressurization unit 24.
  • the depressurization unit 24 is shown to be formed only on the second die roll 20, but is not limited thereto and may be formed on the first die roll 10.
  • the decompression unit 24 decompresses after the second film 4 is in close contact with the wedge 30. If the second film 4 is pressed by the wedge 30 while the second capsule groove 22 is previously depressurized, the second film 4 is placed on the inner surface of the second capsule groove 22. The second film 4 located between the groove 22 and the second capsule groove 22 is unevenly sucked into the second capsule groove 22 and adheres closely. In this state, when the soft capsule 50 is finally molded, there is a problem that the shape of the soft capsule 50 is deformed due to the non-uniform expansion elasticity of the second film 4 forming the outer film.
  • the second film 4 supplied to the upper portion of the second die roll 20 is depressurized in a state in which it is in close contact with the wedge 30, so that the second film 4 is a second capsule. It is configured to be in close contact with the inner surface of the groove (22).
  • the depressurization unit 24 is provided only on the side of the second die roll 20 and is not provided on the side of the first die roll 10. That is, as will be described below, the first film 2 is not decompressed by a separate decompression unit and is transferred in close contact with only the wedge 30.
  • the wedge 30 is formed in a wedge shape having concave curved surfaces symmetrically on both sides of the lower portion so that the pair of die rolls 10 and 20 can rotate without interfering with each other.
  • the tablet supply unit 32 supplies the tablet 40 to the second capsule groove 22 in which the second film 4 is in close contact with the inner surface.
  • the tablet supply unit 32 is formed to penetrate the wedge 30 in the vertical direction and may be disposed adjacent to the second die roll 20 side.
  • the tablet supply unit 32 is only shown as an example in this drawing and may be installed through the wedge 30, or may be separately installed on the lower surface of the wedge 30 to supply the tablet 40.
  • the tablet 40 supplied through the tablet supply unit 32 corresponds to a solid dosage form and means all solid dosage forms similar to that of a conventional tablet.
  • the tablet 40 may be a coated tablet, a pellet, a microcapsule, a sustained-release solid agent, an immediate-release solid agent, a core-shell type solid agent, or the like.
  • 3 is a view showing the injection of a chemical solution from the first chemical injection nozzle to the first film
  • FIG. 4 is a view showing the difference in volume of the chemical solution injected into the first film
  • FIG. 5 is another implementation of the first capsule groove
  • FIG. 6 is a view showing a second chemical solution injection nozzle and a chemical solution discharge part formed in a wedge.
  • the chemical liquid injection nozzle 34, 35 is a first chemical liquid injection nozzle 34 that injects a chemical liquid into the first capsule groove 12 so that the first film 2 is concaved by the amount of the chemical liquid.
  • a second chemical solution injection nozzle 35 for injecting a chemical solution into the second film 4 in close contact with the inner surface of the second capsule groove 22.
  • the chemical solution injection nozzles 34 and 35 are composed of two and the chemical solution is injected into each of the capsule grooves 12 and 22, but is not limited thereto, and the chemical solution injection nozzles 34 and 35 are configured as one. It will be possible to inject a chemical solution into each of the capsule grooves 12 and 22.
  • the first chemical injection nozzle 34 is installed by penetrating the central portion of the wedge 30 in the vertical direction, so that the chemical solution is transferred to the first film 2 transferred by the first die roll 10. Inject. At this time, as described above, the first film 2 is not decompressed by a separate decompression unit and is transferred in close contact with the wedge 30.
  • a chemical solution is injected from the first chemical solution injection nozzle 34 into the first film 2 transferred as described above. Then, the first film 2 is concaved into the first capsule groove 12 by a predetermined depth by the injection force of the chemical liquid injected from the first chemical injection nozzle 34. For example, in the first chemical injection nozzle 34, a chemical solution corresponding to half of the chemical solution accommodated in the entire soft capsule 50 is injected toward the first film 2.
  • the first capsule groove 12 may be formed such that the bottom surface and the sidewall form a right angle as shown in FIG. 4A. That is, the longitudinal section of the first capsule groove 12 may be formed to form a square.
  • the volume is larger than the half (semicircle) of the soft capsule 50 that is actually manufactured, so even if a large amount of the chemical is injected, the chemical can be smoothly injected into the first film 2 .
  • first capsule groove 12 may be formed such that a corner portion where the bottom surface and the side wall meet to form a curved surface as shown in FIG. 5. That is, the first capsule groove 12 may be formed to have a U-shaped longitudinal section. When the first capsule groove 12 is formed in this way, the chemical liquid is injected more smoothly toward the corner portion, so that it may be easier to have the soft capsule 50 shape.
  • a second chemical solution injection nozzle 35 is installed through the wedge 30, thereby injecting the chemical solution toward the second film 4 transferred by the second die roll 20.
  • a cutting part (not shown) for cutting the second film 4 in close contact is formed at the edge of the second capsule groove 22.
  • the first film 2 and the second film 4 passing through the portion where the chemical solution is injected are heat-sealed with each other in the center (the lower part of the wedge 30), and finally, the soft material containing the tablet 40 and the chemical solution A capsule 50 is made.
  • the chemical solution discharge unit 36 Is formed.
  • the chemical liquid discharge part 36 is installed through the wedge 30 like the second chemical liquid injection nozzle 35, and is composed of a second chemical liquid injection nozzle 35 and a pair (one set). Further, the second chemical solution injection nozzle 35 and the chemical solution discharge unit 36 are configured as a set, and a plurality of sets are disposed along the longitudinal direction (front and rear direction) of the wedge 30.
  • a total of seven sets are arranged along the longitudinal direction of the wedge 30, but are not limited thereto, and may be arranged in various numbers according to the design conditions of the wedge 30.
  • the process time can be increased by the size of the second capsule groove 22. I can.
  • the upper surface of the wedge 30 is provided with an injection port 52 for injecting a chemical solution through the second chemical solution injection nozzle 35 and an outlet 54 through which air or a chemical solution is discharged through the chemical solution discharge unit 36.
  • the second chemical liquid injection nozzle 35 and the chemical liquid discharge part 36 are not composed of only a pair (one set), but a second chemical liquid injection nozzle 35 and two chemical liquid discharge parts (36) Alternatively, two second chemical solution injection nozzles 35 and one chemical solution discharge part 36 may be disposed along the longitudinal direction.
  • the second chemical solution injection nozzle 35 and the chemical solution discharge part 36 are arranged in this way, the second chemical solution injection nozzle 35 and the chemical solution discharge part 36 are located at the center line of the second capsule groove 22. It need not be arranged symmetrically with respect to. When arranged in this way, when a large supply of the chemical solution is required or when the chemical solution is to be discharged effectively, the supply and discharge of the chemical solution can be made more smoothly.
  • the second chemical solution injection nozzle 35 injects the chemical solution into the second capsule groove 22, wherein the second chemical solution injection nozzle 35 is eccentric with respect to the center line of the second capsule groove 22. It is preferable to be arranged to inject a chemical solution. This is to discharge by circulating air in the second capsule groove 22 together with the chemical liquid by eccentrically injecting the chemical liquid from the second chemical liquid injection nozzle 35.
  • air may flow into the second capsule groove 22 together with the tablet 40 in the process of supplying the tablet 40 before injecting the chemical solution.
  • the chemical liquid cannot be injected in an appropriate amount, and thus the quality of the manufactured soft capsule 50 may be deteriorated.
  • the second chemical solution injection nozzle 35 is eccentrically disposed in the process of injecting the chemical solution, thereby circulating and discharging the remaining air inside the second capsule groove 22.
  • the air circulated by the injection force of the second chemical liquid injection nozzle 35 described above or a chemical liquid mixed with air may be discharged to the outside through the chemical liquid discharge unit 36 arranged to be spaced apart as much as possible.
  • the chemical liquid discharge part 36 is disposed symmetrically with the second chemical liquid injection nozzle 35 with respect to the center line of the second capsule groove 22, and the air circulating inside the second capsule groove 22 can be discharged. To be.
  • a separation filter 38 may be installed at an inlet of the chemical liquid discharge unit 36 so that air or a chemical liquid mixed with air is discharged and the injected tablet 40 does not pass.
  • the separation filter 38 includes a porous synthetic resin, polysulfone, polypropylene, silicone polymers, polyester, polytetrafluoro ethylene, and cellulose acetate. ), polyacrylonitrile, stainless steel, iron, brass, nylon, and the like may be used. That is, the separation filter 38 is configured to discharge the air inside while preventing the injected tablet 40 from flowing out.
  • the first film 2 and the second film 4 are supplied from both sides of the upper surface of the first die roll 10 and the second die roll 20, respectively, Each of the first die roll 10 and the second die roll 20 is wound around at least one surface and is rotated to the center and conveyed.
  • the depressurization unit 14 decompresses the inside of the second capsule groove 22 and thereby the second film 4 is in close contact with the inner surface of the second capsule groove 22.
  • the configuration in which the second chemical injection nozzle 35 is eccentrically disposed has been described through the embodiment of supplying the tablet 40 after the films 2 and 4 are pressed by the wedge 30, but is not limited thereto. It can be used as a method of discharging the residual air inside the capsule grooves 12 and 22 in the process of manufacturing the soft capsule without. That is, the second chemical liquid injection nozzle 35 is not necessarily disposed only on the side of the second die roll 20, but is also disposed on the side of the first die roll 10 to discharge the remaining air inside the first capsule groove 12. will be.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Preparation (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)

Abstract

La présente invention concerne un dispositif de fabrication de capsule molle. La présente invention comprend : un premier rouleau de matrice pour fournir un premier film, le premier film étant enroulé autour d'au moins une surface de celui-ci et de multiples premières rainures de capsule étant formées le long de la surface périphérique externe du premier rouleau de matrice ; un second rouleau de matrice disposé de manière adjacente au premier rouleau de matrice de façon à fournir un second film, le second film étant enroulé autour d'au moins une surface de celui-ci et de multiples secondes rainures de capsule étant formées le long de la surface périphérique externe du second rouleau de matrice ; des coins installés pour être pressés contre le premier film et le second film enroulés respectivement autour d'une surface du premier rouleau de matrice et d'une surface du second rouleau de matrice ; un dispositif de réduction de pression pour réduire la pression dans les premières rainures de capsule ou les secondes rainures de capsule de telle sorte que le premier film ou le second film est pressé contre la surface interne de celui-ci ; un dispositif d'approvisionnement en comprimés pour approvisionner en comprimés les premières rainures de capsule ou les secondes rainures de capsule ; et des buses d'injection de médicament liquide pour injecter un médicament liquide dans les premières rainures de capsule et les secondes rainures de capsule, formant ainsi des capsules molles. Au moins l'une des buses d'injection de médicament liquide est apte à faire circuler de l'air et le médicament liquide à l'intérieur des premières rainures de capsule ou des secondes rainures de capsule au moyen d'une force de pulvérisation.
PCT/KR2020/003624 2019-03-25 2020-03-17 Dispositif de fabrication de capsule molle WO2020197145A1 (fr)

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KR1020190033808A KR102140014B1 (ko) 2019-03-25 2019-03-25 연질캡슐 제조 장치
KR10-2019-0033808 2019-03-25

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114129531A (zh) * 2021-12-10 2022-03-04 安徽唐堂生物科技有限公司 一种改性淀粉软胶囊制备工艺及设备

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102607454B1 (ko) * 2020-12-18 2023-11-29 코스맥스파마 주식회사 2종 이상의 서로 다른 조성물을 함유한 제제학적으로 안정한 연질캡슐제

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4662155A (en) * 1983-10-06 1987-05-05 Chasman Sydney A Method and apparatus for forming capsules
KR100949173B1 (ko) * 2009-04-14 2010-03-23 주식회사 보창 소프트 캡슐 제조 장치
KR20140080844A (ko) * 2012-12-20 2014-07-01 주식회사 아리바이오 그래뉼 또는 환-함유 투명 연질캡슐, 이의 제조방법 및 제조장치
KR101713593B1 (ko) * 2015-08-21 2017-03-08 주식회사 서흥 고형 제형을 내용물로 함유하는 연질캡슐의 제조 방법
KR20170088283A (ko) * 2016-01-22 2017-08-01 최인규 고속성형이 가능한 약 캡슐 성형장치

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567714A (en) * 1980-11-24 1986-02-04 Chasman Sydney A Method and apparatus for forming capsules
KR101694749B1 (ko) 2015-08-21 2017-01-10 주식회사 서흥 고형 제형을 내용물로 함유하는 연질캡슐 제조 장치
KR101811632B1 (ko) * 2017-08-31 2017-12-26 최인규 연질캡슐 성형기

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4662155A (en) * 1983-10-06 1987-05-05 Chasman Sydney A Method and apparatus for forming capsules
KR100949173B1 (ko) * 2009-04-14 2010-03-23 주식회사 보창 소프트 캡슐 제조 장치
KR20140080844A (ko) * 2012-12-20 2014-07-01 주식회사 아리바이오 그래뉼 또는 환-함유 투명 연질캡슐, 이의 제조방법 및 제조장치
KR101713593B1 (ko) * 2015-08-21 2017-03-08 주식회사 서흥 고형 제형을 내용물로 함유하는 연질캡슐의 제조 방법
KR20170088283A (ko) * 2016-01-22 2017-08-01 최인규 고속성형이 가능한 약 캡슐 성형장치

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114129531A (zh) * 2021-12-10 2022-03-04 安徽唐堂生物科技有限公司 一种改性淀粉软胶囊制备工艺及设备
CN114129531B (zh) * 2021-12-10 2023-08-25 安徽唐堂生物科技有限公司 一种改性淀粉软胶囊制备工艺及设备

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