WO2020197145A1 - Soft capsule manufacturing device - Google Patents

Soft capsule manufacturing device Download PDF

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Publication number
WO2020197145A1
WO2020197145A1 PCT/KR2020/003624 KR2020003624W WO2020197145A1 WO 2020197145 A1 WO2020197145 A1 WO 2020197145A1 KR 2020003624 W KR2020003624 W KR 2020003624W WO 2020197145 A1 WO2020197145 A1 WO 2020197145A1
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WO
WIPO (PCT)
Prior art keywords
capsule
film
chemical liquid
injection nozzle
chemical
Prior art date
Application number
PCT/KR2020/003624
Other languages
French (fr)
Korean (ko)
Inventor
강원호
Original Assignee
유엠에스엔지니어링 주식회사
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Publication of WO2020197145A1 publication Critical patent/WO2020197145A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S53/00—Package making
    • Y10S53/90—Capsules

Definitions

  • the present invention relates to a soft capsule manufacturing apparatus, and more particularly, to a soft capsule manufacturing apparatus for manufacturing a soft capsule containing a tablet and a chemical solution.
  • Capsule-type drugs can also be manufactured in various forms, as long as there is a capsule-type drug that is a capsule only in appearance and is filled with powder inside (in this case, the capsule is separated by pulling by holding both sides of the capsule to expose the powder filled inside), inside There are also drugs that are filled with tablets and liquids, wrapped in a film, and manufactured in the form of soft capsules. In addition, various types of drugs are being manufactured. Hereinafter, a description will be made focusing on a soft capsule manufacturing apparatus for manufacturing the latter type of soft capsule.
  • Korean Patent Registration No. 10-1694749 discloses a'soft capsule manufacturing apparatus containing a solid dosage form'.
  • a unit that thermocompresses and cuts both sides of the gelatin sheet to form a soft capsule contains a solid dosage form consisting of the contents. It provides a soft capsule manufacturing device.
  • tablets are supplied through the right die-roll outer circumferential decompression surface 402. If the outer circumferential surface is decompressed on the right die-roll outer circumferential decompression surface 402 in advance as described above, the gelatin sheet is formed on the right die roll outer circumferential decompression surface 402 In a state in close contact with the wedge segment adhesive surface 803 is met and brought into contact.
  • the gelatin sheet is kept in close contact with the pressure-sensitive surface 402 on the outer periphery of the die roll on the right side, but the gelatin sheet existing between the pressure-sensitive surface 402 and the pressure-sensitive surface 402 is irregularly drawn to the pressure-sensitive surface 402. As it enters, it has irregular expansion elasticity. Therefore, there is a problem in that the shape of the capsule of the final product has a shape that does not correspond to the shape of the pressure-sensitive surface 402. In addition, there is a problem that the thickness of the irregular gelatin sheet caused by the irregular expansion elasticity affects the mass of the injected contents.
  • the present invention provides an apparatus for manufacturing a soft capsule having a structure capable of manufacturing a cross section based on a junction line of a soft capsule containing a tablet and a drug solution to match the shape of the pressure reducing surface of the capsule groove formed on the die roll.
  • the soft capsule manufacturing apparatus supplies the first film with the first film wound on at least one surface, and a plurality of first capsule grooves are formed along the outer circumferential surface.
  • 1 die roll A second die roll disposed adjacent to the first die roll, supplying the second film with a second film wound on at least one surface thereof, and having a plurality of second capsule grooves formed along an outer circumferential surface thereof;
  • a wedge installed in close contact with the first film and the second film wound on one surface of the first die roll and the second die roll;
  • a depressurization unit for depressurizing the first capsule groove or the second capsule groove so that the first film or the second film is in close contact with the inner surface;
  • a tablet supply unit for supplying tablets to the first capsule groove or the second capsule groove;
  • a chemical liquid injection nozzle for injecting a chemical liquid into the first capsule groove and the second capsule groove to form a soft capsule, wherein at least one of the chemical liquid injection nozzles is an inside of the first capsule groove or the second capsule groove by
  • a chemical liquid discharge part for discharging the circulated internal air or a chemical liquid mixed with air may be installed around the chemical liquid injection nozzle.
  • the chemical liquid discharge part may be disposed symmetrically to the chemical liquid injection nozzle with respect to a center line of the first capsule groove or the second capsule groove.
  • a separation filter may be installed at an inlet of the chemical liquid discharge part to discharge only the chemical liquid and prevent the tablet from passing through.
  • the first capsule groove may be formed such that a corner portion where a bottom surface and a side wall meet to form a curved surface.
  • the chemical liquid injection nozzle includes: a first chemical liquid injection nozzle for injecting a chemical liquid into the first capsule groove so that the first film is concaved by the amount of the chemical liquid; And a second chemical solution injection nozzle for injecting a chemical solution into the second film in close contact with the inner surface of the second capsule groove.
  • the first chemical injection nozzle may be installed through the center of the wedge.
  • the second chemical solution injection nozzle is disposed eccentrically with respect to the center line of the second capsule groove, and may circulate the air and the chemical solution inside the second capsule groove by the injection force.
  • a chemical liquid discharge part through which the circulated internal air or a chemical liquid mixed with air is discharged may be installed around the second chemical liquid injection nozzle.
  • the second chemical solution injection nozzle and the chemical solution discharge part may be installed through the wedge, and the second chemical solution injection nozzle and the chemical solution discharge part may be configured as a set, and a plurality of sets may be installed along the length direction of the wedge.
  • the second chemical liquid injection nozzle and the chemical liquid discharge part may be installed through the wedge, and the second chemical liquid injection nozzle and the chemical liquid discharge part may each be composed of at least one or more, and may be disposed along the length direction of the wedge.
  • One of the second chemical liquid injection nozzles and the two chemical liquid discharge parts, or the two second chemical liquid injection nozzles and the one chemical liquid discharge part may be configured and disposed as a set.
  • a soft capsule including a tablet and a chemical solution can be manufactured in a desired shape, thereby improving the reliability of the final manufactured product.
  • the chemical liquid can always be injected in an appropriate amount.
  • FIG. 1 is a view of a soft capsule manufacturing apparatus according to an embodiment of the present invention.
  • Figure 2 is a view showing that the tablet is supplied to the second capsule groove.
  • FIG 3 is a view showing the injection of a chemical solution into a first film from a first chemical solution injection nozzle.
  • FIG. 4 is a view showing a difference in capacity of a chemical solution injected into a first film.
  • FIG. 5 is a view showing another embodiment of the first capsule groove.
  • FIG. 6 is a view showing a second chemical liquid injection nozzle and a chemical liquid discharge part formed in the wedge.
  • FIG. 7 is a view showing another embodiment of a second chemical solution injection nozzle and a chemical solution discharge unit.
  • FIG. 8 is a view showing that air or a chemical liquid mixed with air is circulated in a second capsule groove.
  • first and second may be used to describe various components, but the components should not be limited by the terms. These terms are used only for the purpose of distinguishing one component from another component.
  • FIG. 1 is a view of an apparatus for manufacturing a soft capsule according to an embodiment of the present invention
  • FIG. 2 is a view showing that tablets are supplied to a second capsule groove.
  • the first film 2 is supplied with the first film 2 wound on at least one surface, and a plurality of first films are supplied along the outer circumferential surface.
  • a second die roll 20 is formed;
  • a wedge 30 installed in close contact with the first film 2 and the second film 4 wound on one surface of the first die roll 10 and the second die roll 20;
  • a decompression unit 24 for decompressing the second capsule groove 22 after the second film 4 is in close contact with the wedge 30 so that the second film 4 is in close contact with the inner surface;
  • a tablet supply unit 32 installed in the wedge 30 to supply tablets 40 to the second capsule groove 22;
  • it may include a chemical liquid injection nozzles (34, 35) for injecting a chemical liquid into the first capsule groove 12 and the second capsule groove 22 to form the soft capsule 50.
  • the first film 2 and the second film 4 are supplied from the left and the right, respectively, and are supplied after being cooled in advance in a cooling drum (not shown) disposed on the left and right, respectively.
  • the first film 2 and the second film 4 are made of gelatin or an edible polymer material, and are parts that form an outer film when the soft capsule 50 is manufactured.
  • the first film 2 and the second film 4 are supplied to be wound on at least one surface of a pair of die rolls 10 and 20 disposed on the left and right sides, respectively.
  • the first film 2 and the second film 4 may be supplied to upper ends of the first die roll 10 and the second die roll 20.
  • the films 2 and 4 supplied to the upper ends of the die rolls 10 and 20 are in close contact with the lower surfaces of the wedges 30 disposed thereon.
  • a plurality of capsule grooves 12 and 22 are formed along the outer circumferential surface of the pair of die rolls 10 and 20 at regular center angle intervals.
  • the capsule grooves 12 and 22 are formed to be concave in order to form the film 2 and 4 into a soft capsule 50 shape.
  • a plurality of capsule grooves 12 and 22 are formed at regular intervals along the longitudinal direction of the die rolls 10 and 20. That is, the capsule grooves 12 and 22 are formed by being arranged in a plurality of columns and rows along the outer circumferential surfaces of the die rolls 10 and 20.
  • Each of the decompression units 24 is connected to one side of the inner surface of the second capsule groove 22 to be formed.
  • the depressurization unit 24 is a portion for forming a negative pressure inside the second capsule groove 22 so that the second film 4 is in close contact with the inner surface of the second capsule groove 22, and the second die roll 20 It may be formed to penetrate inside in a radial direction.
  • Equipment for depressurization such as a pump (not shown), may be connected to an end of the depressurization unit 24.
  • the depressurization unit 24 is shown to be formed only on the second die roll 20, but is not limited thereto and may be formed on the first die roll 10.
  • the decompression unit 24 decompresses after the second film 4 is in close contact with the wedge 30. If the second film 4 is pressed by the wedge 30 while the second capsule groove 22 is previously depressurized, the second film 4 is placed on the inner surface of the second capsule groove 22. The second film 4 located between the groove 22 and the second capsule groove 22 is unevenly sucked into the second capsule groove 22 and adheres closely. In this state, when the soft capsule 50 is finally molded, there is a problem that the shape of the soft capsule 50 is deformed due to the non-uniform expansion elasticity of the second film 4 forming the outer film.
  • the second film 4 supplied to the upper portion of the second die roll 20 is depressurized in a state in which it is in close contact with the wedge 30, so that the second film 4 is a second capsule. It is configured to be in close contact with the inner surface of the groove (22).
  • the depressurization unit 24 is provided only on the side of the second die roll 20 and is not provided on the side of the first die roll 10. That is, as will be described below, the first film 2 is not decompressed by a separate decompression unit and is transferred in close contact with only the wedge 30.
  • the wedge 30 is formed in a wedge shape having concave curved surfaces symmetrically on both sides of the lower portion so that the pair of die rolls 10 and 20 can rotate without interfering with each other.
  • the tablet supply unit 32 supplies the tablet 40 to the second capsule groove 22 in which the second film 4 is in close contact with the inner surface.
  • the tablet supply unit 32 is formed to penetrate the wedge 30 in the vertical direction and may be disposed adjacent to the second die roll 20 side.
  • the tablet supply unit 32 is only shown as an example in this drawing and may be installed through the wedge 30, or may be separately installed on the lower surface of the wedge 30 to supply the tablet 40.
  • the tablet 40 supplied through the tablet supply unit 32 corresponds to a solid dosage form and means all solid dosage forms similar to that of a conventional tablet.
  • the tablet 40 may be a coated tablet, a pellet, a microcapsule, a sustained-release solid agent, an immediate-release solid agent, a core-shell type solid agent, or the like.
  • 3 is a view showing the injection of a chemical solution from the first chemical injection nozzle to the first film
  • FIG. 4 is a view showing the difference in volume of the chemical solution injected into the first film
  • FIG. 5 is another implementation of the first capsule groove
  • FIG. 6 is a view showing a second chemical solution injection nozzle and a chemical solution discharge part formed in a wedge.
  • the chemical liquid injection nozzle 34, 35 is a first chemical liquid injection nozzle 34 that injects a chemical liquid into the first capsule groove 12 so that the first film 2 is concaved by the amount of the chemical liquid.
  • a second chemical solution injection nozzle 35 for injecting a chemical solution into the second film 4 in close contact with the inner surface of the second capsule groove 22.
  • the chemical solution injection nozzles 34 and 35 are composed of two and the chemical solution is injected into each of the capsule grooves 12 and 22, but is not limited thereto, and the chemical solution injection nozzles 34 and 35 are configured as one. It will be possible to inject a chemical solution into each of the capsule grooves 12 and 22.
  • the first chemical injection nozzle 34 is installed by penetrating the central portion of the wedge 30 in the vertical direction, so that the chemical solution is transferred to the first film 2 transferred by the first die roll 10. Inject. At this time, as described above, the first film 2 is not decompressed by a separate decompression unit and is transferred in close contact with the wedge 30.
  • a chemical solution is injected from the first chemical solution injection nozzle 34 into the first film 2 transferred as described above. Then, the first film 2 is concaved into the first capsule groove 12 by a predetermined depth by the injection force of the chemical liquid injected from the first chemical injection nozzle 34. For example, in the first chemical injection nozzle 34, a chemical solution corresponding to half of the chemical solution accommodated in the entire soft capsule 50 is injected toward the first film 2.
  • the first capsule groove 12 may be formed such that the bottom surface and the sidewall form a right angle as shown in FIG. 4A. That is, the longitudinal section of the first capsule groove 12 may be formed to form a square.
  • the volume is larger than the half (semicircle) of the soft capsule 50 that is actually manufactured, so even if a large amount of the chemical is injected, the chemical can be smoothly injected into the first film 2 .
  • first capsule groove 12 may be formed such that a corner portion where the bottom surface and the side wall meet to form a curved surface as shown in FIG. 5. That is, the first capsule groove 12 may be formed to have a U-shaped longitudinal section. When the first capsule groove 12 is formed in this way, the chemical liquid is injected more smoothly toward the corner portion, so that it may be easier to have the soft capsule 50 shape.
  • a second chemical solution injection nozzle 35 is installed through the wedge 30, thereby injecting the chemical solution toward the second film 4 transferred by the second die roll 20.
  • a cutting part (not shown) for cutting the second film 4 in close contact is formed at the edge of the second capsule groove 22.
  • the first film 2 and the second film 4 passing through the portion where the chemical solution is injected are heat-sealed with each other in the center (the lower part of the wedge 30), and finally, the soft material containing the tablet 40 and the chemical solution A capsule 50 is made.
  • the chemical solution discharge unit 36 Is formed.
  • the chemical liquid discharge part 36 is installed through the wedge 30 like the second chemical liquid injection nozzle 35, and is composed of a second chemical liquid injection nozzle 35 and a pair (one set). Further, the second chemical solution injection nozzle 35 and the chemical solution discharge unit 36 are configured as a set, and a plurality of sets are disposed along the longitudinal direction (front and rear direction) of the wedge 30.
  • a total of seven sets are arranged along the longitudinal direction of the wedge 30, but are not limited thereto, and may be arranged in various numbers according to the design conditions of the wedge 30.
  • the process time can be increased by the size of the second capsule groove 22. I can.
  • the upper surface of the wedge 30 is provided with an injection port 52 for injecting a chemical solution through the second chemical solution injection nozzle 35 and an outlet 54 through which air or a chemical solution is discharged through the chemical solution discharge unit 36.
  • the second chemical liquid injection nozzle 35 and the chemical liquid discharge part 36 are not composed of only a pair (one set), but a second chemical liquid injection nozzle 35 and two chemical liquid discharge parts (36) Alternatively, two second chemical solution injection nozzles 35 and one chemical solution discharge part 36 may be disposed along the longitudinal direction.
  • the second chemical solution injection nozzle 35 and the chemical solution discharge part 36 are arranged in this way, the second chemical solution injection nozzle 35 and the chemical solution discharge part 36 are located at the center line of the second capsule groove 22. It need not be arranged symmetrically with respect to. When arranged in this way, when a large supply of the chemical solution is required or when the chemical solution is to be discharged effectively, the supply and discharge of the chemical solution can be made more smoothly.
  • the second chemical solution injection nozzle 35 injects the chemical solution into the second capsule groove 22, wherein the second chemical solution injection nozzle 35 is eccentric with respect to the center line of the second capsule groove 22. It is preferable to be arranged to inject a chemical solution. This is to discharge by circulating air in the second capsule groove 22 together with the chemical liquid by eccentrically injecting the chemical liquid from the second chemical liquid injection nozzle 35.
  • air may flow into the second capsule groove 22 together with the tablet 40 in the process of supplying the tablet 40 before injecting the chemical solution.
  • the chemical liquid cannot be injected in an appropriate amount, and thus the quality of the manufactured soft capsule 50 may be deteriorated.
  • the second chemical solution injection nozzle 35 is eccentrically disposed in the process of injecting the chemical solution, thereby circulating and discharging the remaining air inside the second capsule groove 22.
  • the air circulated by the injection force of the second chemical liquid injection nozzle 35 described above or a chemical liquid mixed with air may be discharged to the outside through the chemical liquid discharge unit 36 arranged to be spaced apart as much as possible.
  • the chemical liquid discharge part 36 is disposed symmetrically with the second chemical liquid injection nozzle 35 with respect to the center line of the second capsule groove 22, and the air circulating inside the second capsule groove 22 can be discharged. To be.
  • a separation filter 38 may be installed at an inlet of the chemical liquid discharge unit 36 so that air or a chemical liquid mixed with air is discharged and the injected tablet 40 does not pass.
  • the separation filter 38 includes a porous synthetic resin, polysulfone, polypropylene, silicone polymers, polyester, polytetrafluoro ethylene, and cellulose acetate. ), polyacrylonitrile, stainless steel, iron, brass, nylon, and the like may be used. That is, the separation filter 38 is configured to discharge the air inside while preventing the injected tablet 40 from flowing out.
  • the first film 2 and the second film 4 are supplied from both sides of the upper surface of the first die roll 10 and the second die roll 20, respectively, Each of the first die roll 10 and the second die roll 20 is wound around at least one surface and is rotated to the center and conveyed.
  • the depressurization unit 14 decompresses the inside of the second capsule groove 22 and thereby the second film 4 is in close contact with the inner surface of the second capsule groove 22.
  • the configuration in which the second chemical injection nozzle 35 is eccentrically disposed has been described through the embodiment of supplying the tablet 40 after the films 2 and 4 are pressed by the wedge 30, but is not limited thereto. It can be used as a method of discharging the residual air inside the capsule grooves 12 and 22 in the process of manufacturing the soft capsule without. That is, the second chemical liquid injection nozzle 35 is not necessarily disposed only on the side of the second die roll 20, but is also disposed on the side of the first die roll 10 to discharge the remaining air inside the first capsule groove 12. will be.

Abstract

The present invention relates to a soft capsule manufacturing device. The present invention comprises: a first die roll for supplying a first film while the first film is wound around at least one surface thereof, multiple first capsule grooves being formed along the outer peripheral surface of the first die role; a second die role disposed adjacent to the first die role so as to supply a second film while the second film is wound around at least one surface thereof, multiple second capsule grooves being formed along the outer peripheral surface of the second die role; wedges installed to be forced against the first film and the second film wound one surfaces of the first die roll and the second die roll, respectively; a pressure reducer for reducing the pressure in the first capsule grooves or the second capsule grooves such that the first film or the second film is forced against the inner surface thereof; a tablet supplier for supplying tablets to the first capsule grooves or the second capsule grooves; and liquid medication injection nozzles for injecting a liquid medication into the first capsule grooves and the second capsule grooves, thereby forming soft capsules. At least one of the liquid medication injection nozzles is capable of circulating air and the liquid medication inside the first capsule grooves or the second capsule grooves by means of spraying power.

Description

연질캡슐 제조 장치Soft capsule manufacturing device
본 발명은 연질캡슐 제조 장치에 관한 것으로, 보다 상세하게는 정제와 약액을 포함하는 연질캡슐을 제조하기 위한 연질캡슐 제조 장치에 관한 것이다.The present invention relates to a soft capsule manufacturing apparatus, and more particularly, to a soft capsule manufacturing apparatus for manufacturing a soft capsule containing a tablet and a chemical solution.
본 출원은 2019. 3. 25.자 한국 특허 출원 제10-2019-0033808호에 기초한 우선권의 이익을 주장하며, 해당 한국 특허 출원의 문헌에 개시된 모든 내용은 본 명세서의 일부로서 포함된다.This application claims the benefit of priority based on Korean Patent Application No. 10-2019-0033808 filed on March 25, 2019, and all contents disclosed in the documents of the Korean patent application are incorporated as part of this specification.
캡슐 형태의 약제도 다양한 형태로 제조될 수 있는데 외형만 캡슐이고 내부에는 파우더가 채워진 캡슐형 약제가 있는가 하면(이 경우 캡슐의 양측을 잡고서 당기면 캡슐이 분리되어 내부에 채워진 파우더가 노출된다), 내부에 정제와 약액이 채워지면서 이를 필름으로 감싸 연질캡슐 형태로 제조하는 약제도 있다. 그 외에도 다양한 형태의 약제가 제조되고 있는데, 이하에서는 후자 형태의 연질캡슐을 제조하는 연질캡슐 제조 장치를 중심으로 설명하기로 한다. Capsule-type drugs can also be manufactured in various forms, as long as there is a capsule-type drug that is a capsule only in appearance and is filled with powder inside (in this case, the capsule is separated by pulling by holding both sides of the capsule to expose the powder filled inside), inside There are also drugs that are filled with tablets and liquids, wrapped in a film, and manufactured in the form of soft capsules. In addition, various types of drugs are being manufactured. Hereinafter, a description will be made focusing on a soft capsule manufacturing apparatus for manufacturing the latter type of soft capsule.
한국등록특허 제10-1694749호에는 '고형 제형을 내용물로 함유하는 연질캡슐 제조 장치'에 대하여 개시되어 있다. Korean Patent Registration No. 10-1694749 discloses a'soft capsule manufacturing apparatus containing a solid dosage form'.
상기 특허에서는 i) 제 1 젤라틴 냉동드럼(10)에서 냉각된 제 1 젤라틴 시트를 제 1 이송 롤러(12)를 통해 좌측 다이롤(30) 상단에 공급하는 유니트; ii) 제 2 젤라틴 냉동드럼(20)에서 냉각된 제 2 젤라틴 시트를 제 2 이송 롤러(22)를 통해 우측 다이롤(40) 상단에 공급하는 유니트; iii) 타블렛 공급 슈터(50)로부터 공급된 타블렛을 타블렛 이송 롤러(45)를 통해 우측 다이롤 외주 감압면(402)으로 타블렛을 이송 투입하는 유니트; 및 iv) 좌측 다이롤 외주부(301)에 공급된 제 1 젤라틴 시트와 우측 다이롤 외주부(401)에 공급된 타블렛이 포켓(404)에 투입된 타블렛 함유 제 2 젤라틴 시트를 좌측 및 우측 다이롤이 서로 접촉하는 봉입 성형부(403)에서 중앙부 내용액 주입관(801)으로부터 내용액을 주입한 후 양쪽 젤라틴 시트 면을 서로 열압착 절단시켜 연질캡슐로 성형시키는 유니트;로 이루어진 고형 제형을 내용물로 함유하는 연질캡슐 제조 장치를 제공하고 있다. In the above patent, i) a unit for supplying the first gelatin sheet cooled in the first gelatin freezing drum 10 to the top of the left die roll 30 through the first transfer roller 12; ii) a unit for supplying the second gelatin sheet cooled in the second gelatin freezing drum 20 to the upper end of the right die roll 40 through the second transfer roller 22; iii) a unit for transferring and inserting the tablet supplied from the tablet supply shooter 50 to the right die roll outer peripheral pressure reducing surface 402 through the tablet transfer roller 45; And iv) the first gelatin sheet supplied to the left die roll outer circumferential part 301 and the tablet supplied to the right die roll outer circumferential part 401 are inserted into the pocket 404 and the second gelatin sheet containing the tablet is inserted into the left and right die rolls. After injecting the liquid from the central liquid injection pipe 801 in the encapsulated molding part 403 in contact, a unit that thermocompresses and cuts both sides of the gelatin sheet to form a soft capsule; contains a solid dosage form consisting of the contents. It provides a soft capsule manufacturing device.
상기 특허에서는 우측 다이롤 외주 감압면(402)을 통해 타블렛을 공급하는데, 이와 같이 미리 우측 다이롤 외주 감압면(402)에 외주면을 감압하여 형성하면 젤라틴 시트가 우측 다이롤 외주 감압면(402)에 밀착된 상태로 웨지 세그먼트 접착면(803)을 만나 접촉하게 된다. In the above patent, tablets are supplied through the right die-roll outer circumferential decompression surface 402. If the outer circumferential surface is decompressed on the right die-roll outer circumferential decompression surface 402 in advance as described above, the gelatin sheet is formed on the right die roll outer circumferential decompression surface 402 In a state in close contact with the wedge segment adhesive surface 803 is met and brought into contact.
이때, 젤라틴 시트는 우측 다이롤 외주 감압면(402)에 밀착된 상태를 유지하게 되지만, 감압면(402)과 감압면(402) 사이에 존재하는 젤라틴 시트가 불규칙하게 감압면(402)으로 끌려들어가게 되어 불규칙한 팽창탄성을 가지게 된다. 따라서, 최종 제품의 캡슐 모양이 감압면(402)의 형상에 대응되지 않는 형상을 가지게 되는 문제가 있다. 아울러 불규칙한 팽창탄성으로 인해 야기되는 불규칙한 젤라틴 시트의 두께는 주입되는 내용물의 질량에 영향을 주는 문제가 있다.At this time, the gelatin sheet is kept in close contact with the pressure-sensitive surface 402 on the outer periphery of the die roll on the right side, but the gelatin sheet existing between the pressure-sensitive surface 402 and the pressure-sensitive surface 402 is irregularly drawn to the pressure-sensitive surface 402. As it enters, it has irregular expansion elasticity. Therefore, there is a problem in that the shape of the capsule of the final product has a shape that does not correspond to the shape of the pressure-sensitive surface 402. In addition, there is a problem that the thickness of the irregular gelatin sheet caused by the irregular expansion elasticity affects the mass of the injected contents.
본 발명은 정제와 약액을 포함하는 연질캡슐의 접합선을 기준으로 한 횡단면을 다이롤에 형성되어 있는 캡슐홈의 감압면 형상과 일치하게 제조할 수 있는 구조를 가진 연질캡슐 제조 장치를 제공하는 것이다.The present invention provides an apparatus for manufacturing a soft capsule having a structure capable of manufacturing a cross section based on a junction line of a soft capsule containing a tablet and a drug solution to match the shape of the pressure reducing surface of the capsule groove formed on the die roll.
본 발명의 일 실시예에 따르면, 본 발명에 의한 연질캡슐 제조 장치는 적어도 일면에 제1 필름이 감아진 상태로 상기 제1 필름을 공급하고, 외주면을 따라 복수개의 제1 캡슐홈이 형성되는 제1 다이롤; 상기 제1 다이롤에 인접하게 배치되고, 적어도 일면에 제2 필름이 감아진 상태로 상기 제2 필름을 공급하며, 외주면을 따라 복수개의 제2 캡슐홈이 형성되는 제2 다이롤; 상기 제1 다이롤 및 제2 다이롤의 일면에 감아진 상기 제 1 필름 및 제2 필름에 밀착되게 설치되는 웨지; 상기 제1 캡슐홈 또는 제2 캡슐홈을 감압하여 상기 제1 필름 또는 제2 필름이 내면에 밀착되게 하는 감압부; 상기 제1 캡슐홈 또는 제2 캡슐홈으로 정제를 공급하는 정제 공급부; 및 상기 제1 캡슐홈 및 제2 캡슐홈으로 약액을 주입하여 연질캡슐을 성형하는 약액 주입노즐을 포함하고, 상기 약액 주입노즐 중 적어도 하나는 분사력으로 상기 제1 캡슐홈 또는 제2 캡슐홈의 내부 공기 및 약액을 순환시킬 수 있다.According to an embodiment of the present invention, the soft capsule manufacturing apparatus according to the present invention supplies the first film with the first film wound on at least one surface, and a plurality of first capsule grooves are formed along the outer circumferential surface. 1 die roll; A second die roll disposed adjacent to the first die roll, supplying the second film with a second film wound on at least one surface thereof, and having a plurality of second capsule grooves formed along an outer circumferential surface thereof; A wedge installed in close contact with the first film and the second film wound on one surface of the first die roll and the second die roll; A depressurization unit for depressurizing the first capsule groove or the second capsule groove so that the first film or the second film is in close contact with the inner surface; A tablet supply unit for supplying tablets to the first capsule groove or the second capsule groove; And a chemical liquid injection nozzle for injecting a chemical liquid into the first capsule groove and the second capsule groove to form a soft capsule, wherein at least one of the chemical liquid injection nozzles is an inside of the first capsule groove or the second capsule groove by a spraying force Air and chemical liquids can be circulated.
상기 약액 주입노즐의 주변에는 상기 순환된 내부 공기 또는 공기가 혼합된 약액이 배출되는 약액 배출부가 설치될 수 있다.A chemical liquid discharge part for discharging the circulated internal air or a chemical liquid mixed with air may be installed around the chemical liquid injection nozzle.
상기 약액 배출부는 상기 제1 캡슐홈 또는 제2 캡슐홈의 중심선에 대하여 상기 약액 주입노즐과 대칭되게 배치될 수 있다.The chemical liquid discharge part may be disposed symmetrically to the chemical liquid injection nozzle with respect to a center line of the first capsule groove or the second capsule groove.
상기 약액 배출부의 입구에는 약액만 배출되고 상기 정제는 통과하지 못하도록 분리필터가 설치될 수 있다.A separation filter may be installed at an inlet of the chemical liquid discharge part to discharge only the chemical liquid and prevent the tablet from passing through.
상기 제1 캡슐홈은 바닥면과 측벽이 만나는 모서리 부분이 곡면을 이루도록 형성될 수 있다.The first capsule groove may be formed such that a corner portion where a bottom surface and a side wall meet to form a curved surface.
상기 약액 주입노즐은, 상기 제1 캡슐홈으로 약액을 주입하여 상기 제1 필름이 약액의 용량만큼 요입되게 하는 제1 약액 주입노즐; 및 상기 제2 캡슐홈의 내면에 밀착된 상기 제2 필름으로 약액을 주입하는 제2 약액 주입노즐을 포함할 수 있다.The chemical liquid injection nozzle includes: a first chemical liquid injection nozzle for injecting a chemical liquid into the first capsule groove so that the first film is concaved by the amount of the chemical liquid; And a second chemical solution injection nozzle for injecting a chemical solution into the second film in close contact with the inner surface of the second capsule groove.
상기 제1 약액 주입노즐은 상기 웨지의 중앙을 관통하여 설치될 수 있다.The first chemical injection nozzle may be installed through the center of the wedge.
상기 제2 약액 주입노즐은 상기 제2 캡슐홈의 중심선에 대하여 편심되게 배치되고, 분사력으로 상기 제2 캡슐홈의 내부 공기 및 약액을 순환시킬 수 있다.The second chemical solution injection nozzle is disposed eccentrically with respect to the center line of the second capsule groove, and may circulate the air and the chemical solution inside the second capsule groove by the injection force.
상기 제2 약액 주입노즐의 주변에는 상기 순환된 내부 공기 또는 공기가 혼합된 약액이 배출되는 약액 배출부가 설치될 수 있다.A chemical liquid discharge part through which the circulated internal air or a chemical liquid mixed with air is discharged may be installed around the second chemical liquid injection nozzle.
상기 제2 약액 주입노즐 및 약액 배출부는 상기 웨지를 관통하여 설치되고, 상기 제2 약액 주입노즐 및 약액 배출부는 한 세트로 구성되어 상기 웨지의 길이방향을 따라 복수의 세트가 설치될 수 있다.The second chemical solution injection nozzle and the chemical solution discharge part may be installed through the wedge, and the second chemical solution injection nozzle and the chemical solution discharge part may be configured as a set, and a plurality of sets may be installed along the length direction of the wedge.
상기 제2 약액 주입노즐 및 약액 배출부는 상기 웨지를 관통하여 설치되고, 상기 제2 약액 주입노즐 및 약액 배출부는 각각이 적어도 하나 이상으로 구성되어 상기 웨지의 길이방향을 따라 배치될 수 있다. The second chemical liquid injection nozzle and the chemical liquid discharge part may be installed through the wedge, and the second chemical liquid injection nozzle and the chemical liquid discharge part may each be composed of at least one or more, and may be disposed along the length direction of the wedge.
1개의 상기 제2 약액 주입노즐 및 2개의 상기 약액 배출부, 또는 2개의 상기 제2 약액 주입노즐 및 1개의 상기 약액 배출부가 한 세트로 구성되어 배치될 수 있다.One of the second chemical liquid injection nozzles and the two chemical liquid discharge parts, or the two second chemical liquid injection nozzles and the one chemical liquid discharge part may be configured and disposed as a set.
본 발명의 일 실시예에 따르면, 정제와 약액을 포함하는 연질캡슐을 목표하였던 형상대로 제조할 수 있어 최종 제조된 제품의 신뢰성을 향상시킬 수 있다.According to an embodiment of the present invention, a soft capsule including a tablet and a chemical solution can be manufactured in a desired shape, thereby improving the reliability of the final manufactured product.
또한, 본 발명의 일 실시예에 따르면, 약액 주입노즐의 분사력을 이용하여 캡슐홈의 내부 잔존공기를 순환시켜 배출시킴으로써 약액이 항상 적정 용량만큼 주입될 수 있다. In addition, according to an embodiment of the present invention, by circulating and discharging the remaining air inside the capsule groove by using the spraying force of the chemical liquid injection nozzle, the chemical liquid can always be injected in an appropriate amount.
도 1은 본 발명의 일 실시예에 따른 연질캡슐 제조 장치의 도면.1 is a view of a soft capsule manufacturing apparatus according to an embodiment of the present invention.
도 2는 제2 캡슐홈에 정제가 공급되는 것을 보인 도면.Figure 2 is a view showing that the tablet is supplied to the second capsule groove.
도 3은 제1 약액 주입노즐에서 제1 필름으로 약액을 주입하는 것을 보인 도면. 3 is a view showing the injection of a chemical solution into a first film from a first chemical solution injection nozzle.
도 4는 제1 필름으로 주입되는 약액의 용량 차이를 보인 도면.4 is a view showing a difference in capacity of a chemical solution injected into a first film.
도 5는 제1 캡슐홈의 다른 실시예를 보인 도면. 5 is a view showing another embodiment of the first capsule groove.
도 6은 웨지에 형성된 제2 약액 주입노즐 및 약액 배출부를 보인 도면.6 is a view showing a second chemical liquid injection nozzle and a chemical liquid discharge part formed in the wedge.
도 7은 제2 약액 주입노즐 및 약액 배출부의 다른 실시예를 보인 도면.7 is a view showing another embodiment of a second chemical solution injection nozzle and a chemical solution discharge unit.
도 8은 제2 캡슐홈에서 공기 또는 공기가 혼합된 약액이 순환되는 것을 보인 도면.8 is a view showing that air or a chemical liquid mixed with air is circulated in a second capsule groove.
본 발명은 다양한 변환을 가할 수 있고 여러 가지 실시예를 가질 수 있는 바, 특정 실시예들을 도면에 예시하고 상세하게 설명하고자 한다. 그러나, 이는 본 발명을 특정한 실시 형태에 대해 한정하려는 것이 아니며, 본 발명의 사상 및 기술 범위에 포함되는 모든 변환, 균등물 내지 대체물을 포함하는 것으로 이해되어야 한다. 본 발명을 설명함에 있어서 관련된 공지 기술에 대한 구체적인 설명이 본 발명의 요지를 흐릴 수 있다고 판단되는 경우 그 상세한 설명을 생략한다.In the present invention, various transformations may be applied and various embodiments may be provided, and specific embodiments will be illustrated in the drawings and described in detail. However, this is not intended to limit the present invention to a specific embodiment, it is to be understood to include all conversions, equivalents, and substitutes included in the spirit and scope of the present invention. In describing the present invention, when it is determined that a detailed description of a related known technology may obscure the subject matter of the present invention, a detailed description thereof will be omitted.
제1, 제2 등의 용어는 다양한 구성요소들을 설명하는데 사용될 수 있지만, 상기 구성요소들은 상기 용어들에 의해 한정되어서는 안 된다. 상기 용어들은 하나의 구성요소를 다른 구성요소로부터 구별하는 목적으로만 사용된다.Terms such as first and second may be used to describe various components, but the components should not be limited by the terms. These terms are used only for the purpose of distinguishing one component from another component.
본 출원에서 사용한 용어는 단지 특정한 실시 예를 설명하기 위해 사용된 것으로, 본 발명을 한정하려는 의도가 아니다. 단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한, 복수의 표현을 포함한다. 본 출원에서, "포함한다" 또는 "가지다" 등의 용어는 명세서 상에 기재된 특징, 숫자, 단계, 동작, 구성요소, 부품 또는 이들을 조합한 것이 존재함을 지정하려는 것이지, 하나 또는 그 이상의 다른 특징들이나 숫자, 단계, 동작, 구성요소, 부품 또는 이들을 조합한 것들의 존재 또는 부가 가능성을 미리 배제하지 않는 것으로 이해되어야 한다.The terms used in the present application are used only to describe specific embodiments, and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly indicates otherwise. In the present application, terms such as "comprises" or "have" are intended to designate the presence of features, numbers, steps, actions, components, parts, or combinations thereof described in the specification, but one or more other features. It is to be understood that the presence or addition of elements or numbers, steps, actions, components, parts, or combinations thereof, does not preclude in advance.
이하, 본 발명에 의한 연질캡슐 제조 장치의 일 실시예를 첨부도면을 참조하여 상세히 설명하기로 하며, 첨부 도면을 참조하여 설명함에 있어, 동일하거나 대응하는 구성 요소는 동일한 도면번호를 부여하고 이에 대한 중복되는 설명은 생략하기로 한다.Hereinafter, an embodiment of a soft capsule manufacturing apparatus according to the present invention will be described in detail with reference to the accompanying drawings, and in the description with reference to the accompanying drawings, the same or corresponding components are given the same reference numbers and Redundant descriptions will be omitted.
도 1은 본 발명의 일 실시예에 따른 연질캡슐 제조 장치의 도면이고, 도 2는 제2 캡슐홈에 정제가 공급되는 것을 보인 도면이다.1 is a view of an apparatus for manufacturing a soft capsule according to an embodiment of the present invention, and FIG. 2 is a view showing that tablets are supplied to a second capsule groove.
이에 도시된 바에 따르면, 본 발명의 일 실시예에 따른 연질캡슐 제조 장치는 적어도 일면에 제1 필름(2)이 감아진 상태로 상기 제1 필름(2)을 공급하고, 외주면을 따라 복수개의 제1 캡슐홈(12)이 형성되는 제1 다이롤(10); 상기 제1 다이롤(10)에 인접하게 배치되고, 적어도 일면에 제2 필름(4)이 감아진 상태로 상기 제2 필름(4)을 공급하며, 외주면을 따라 복수개의 제2 캡슐홈(22)이 형성되는 제2 다이롤(20); 상기 제1 다이롤(10) 및 제2 다이롤(20)의 일면에 감아진 상기 제 1 필름(2) 및 제2 필름(4)에 밀착되게 설치되는 웨지(30); 상기 제2 필름(4)이 상기 웨지(30)와 밀착된 후, 상기 제2 캡슐홈(22)을 감압하여 상기 제2 필름(4)이 내면에 밀착되게 하는 감압부(24); 상기 웨지(30)에 설치되어 상기 제2 캡슐홈(22)으로 정제(40)를 공급하는 정제 공급부(32); 및 상기 제1 캡슐홈(12) 및 제2 캡슐홈(22)으로 약액을 주입하여 연질캡슐(50)을 성형하는 약액 주입노즐(34,35)을 포함할 수 있다. As shown, in the soft capsule manufacturing apparatus according to an embodiment of the present invention, the first film 2 is supplied with the first film 2 wound on at least one surface, and a plurality of first films are supplied along the outer circumferential surface. 1 first die roll 10 in which the capsule groove 12 is formed; It is disposed adjacent to the first die roll 10 and supplies the second film 4 with the second film 4 wound on at least one surface, and a plurality of second capsule grooves 22 along the outer circumferential surface thereof. ) A second die roll 20 is formed; A wedge 30 installed in close contact with the first film 2 and the second film 4 wound on one surface of the first die roll 10 and the second die roll 20; A decompression unit 24 for decompressing the second capsule groove 22 after the second film 4 is in close contact with the wedge 30 so that the second film 4 is in close contact with the inner surface; A tablet supply unit 32 installed in the wedge 30 to supply tablets 40 to the second capsule groove 22; And it may include a chemical liquid injection nozzles (34, 35) for injecting a chemical liquid into the first capsule groove 12 and the second capsule groove 22 to form the soft capsule 50.
제1 필름(2) 및 제2 필름(4)은 각각 좌측 및 우측에서 각각 공급이 되는데, 좌우에 각각 배치된 냉각 드럼(미도시)에서 미리 냉각된 후 공급된다. 제1 필름(2) 및 제2 필름(4)은 젤라틴 또는 식용 가능한 고분자물질 소재로 만들어지는 것으로서, 연질캡슐(50) 제조시 외막을 이루는 부분이다. The first film 2 and the second film 4 are supplied from the left and the right, respectively, and are supplied after being cooled in advance in a cooling drum (not shown) disposed on the left and right, respectively. The first film 2 and the second film 4 are made of gelatin or an edible polymer material, and are parts that form an outer film when the soft capsule 50 is manufactured.
제1 필름(2) 및 제2 필름(4)은 좌우에 각각 배치된 한 쌍의 다이롤(10,20)의 적어도 일면에 감아지도록 공급된다. 도 1을 참고하면, 제1 필름(2) 및 제2 필름(4)은 제1 다이롤(10) 및 제2 다이롤(20)의 상단부로 공급될 수 있다. 다이롤(10,20)의 상단부로 공급된 필름(2,4)은 상부에 배치된 웨지(30)의 하면에 밀착된다. The first film 2 and the second film 4 are supplied to be wound on at least one surface of a pair of die rolls 10 and 20 disposed on the left and right sides, respectively. Referring to FIG. 1, the first film 2 and the second film 4 may be supplied to upper ends of the first die roll 10 and the second die roll 20. The films 2 and 4 supplied to the upper ends of the die rolls 10 and 20 are in close contact with the lower surfaces of the wedges 30 disposed thereon.
한 쌍의 다이롤(10,20)에는 외주면을 따라 복수개의 캡슐홈(12,22)이 일정한 중심각 간격으로 형성된다. 캡슐홈(12,22)은 필름(2,4)을 연질캡슐(50) 형상으로 성형하기 위해 요입되게 형성된다. 그리고, 캡슐홈(12,22)은 다이롤(10,20)의 길이방향을 따라 복수개가 일정한 간격으로 형성된다. 즉, 캡슐홈(12,22)은 다이롤(10,20)의 외주면을 따라 복수의 열 및 행으로 배치되어 형성된다. A plurality of capsule grooves 12 and 22 are formed along the outer circumferential surface of the pair of die rolls 10 and 20 at regular center angle intervals. The capsule grooves 12 and 22 are formed to be concave in order to form the film 2 and 4 into a soft capsule 50 shape. In addition, a plurality of capsule grooves 12 and 22 are formed at regular intervals along the longitudinal direction of the die rolls 10 and 20. That is, the capsule grooves 12 and 22 are formed by being arranged in a plurality of columns and rows along the outer circumferential surfaces of the die rolls 10 and 20.
제2 캡슐홈(22)의 내면 일측에는 각각 감압부(24)가 연결되어 형성된다. 감압부(24)는 제2 캡슐홈(22) 내부에 음압을 형성하여 제2 필름(4)이 제2 캡슐홈(22)의 내면에 밀착되도록 하기 위한 부분으로서, 제2 다이롤(20) 내부에 반경 방향으로 관통하여 형성될 수 있다. 감압부(24)의 단부는 펌프(미도시) 등과 같은 감압을 위한 장비가 연결될 수 있다. 본 도면에서 감압부(24)는 제2 다이롤(20)에만 형성되는 것으로 도시하였으나, 이에 제한되지 않고 제1 다이롤(10)에 형성될 수도 있다. Each of the decompression units 24 is connected to one side of the inner surface of the second capsule groove 22 to be formed. The depressurization unit 24 is a portion for forming a negative pressure inside the second capsule groove 22 so that the second film 4 is in close contact with the inner surface of the second capsule groove 22, and the second die roll 20 It may be formed to penetrate inside in a radial direction. Equipment for depressurization, such as a pump (not shown), may be connected to an end of the depressurization unit 24. In this drawing, the depressurization unit 24 is shown to be formed only on the second die roll 20, but is not limited thereto and may be formed on the first die roll 10.
본 실시예에서 중요한 것은 감압부(24)는 제2 필름(4)이 웨지(30)에 의해 밀착된 후에 감압시킨다는 것이다. 만약에 제2 캡슐홈(22)이 미리 감압된 상태에서 웨지(30)에 의해 제2 필름(4)이 눌러지면 제2 필름(4)이 제2 캡슐홈(22)의 내면에 제2 캡슐홈(22)과 제2 캡슐홈(22) 사이에 위치한 제2 필름(4)이 불균일하게 제2 캡슐홈(22)으로 빨려 들어가서 밀착된다. 이 상태에서 연질캡슐(50)이 최종적으로 성형되면 외막을 형성하는 제2 필름(4)이 불균일한 팽창탄성으로 인해 연질캡슐(50) 형상이 변형되는 문제가 있다. 따라서, 본 실시예에서는 제2 다이롤(20)의 상부로 공급된 제2 필름(4)이 웨지(30)에 의해 밀착된 상태에서 감압이 이루어지도록 하여 제2 필름(4)이 제2 캡슐홈(22)의 내면에 밀착되도록 구성하였다. What is important in this embodiment is that the decompression unit 24 decompresses after the second film 4 is in close contact with the wedge 30. If the second film 4 is pressed by the wedge 30 while the second capsule groove 22 is previously depressurized, the second film 4 is placed on the inner surface of the second capsule groove 22. The second film 4 located between the groove 22 and the second capsule groove 22 is unevenly sucked into the second capsule groove 22 and adheres closely. In this state, when the soft capsule 50 is finally molded, there is a problem that the shape of the soft capsule 50 is deformed due to the non-uniform expansion elasticity of the second film 4 forming the outer film. Accordingly, in this embodiment, the second film 4 supplied to the upper portion of the second die roll 20 is depressurized in a state in which it is in close contact with the wedge 30, so that the second film 4 is a second capsule. It is configured to be in close contact with the inner surface of the groove (22).
다만, 본 실시예에서 감압부(24)는 제2 다이롤(20) 측에만 구비되고 제1 다이롤(10) 측에는 구비되지 않는다. 즉, 이하에서도 설명하겠지만 제1 필름(2)은 별도의 감압부에 의해 감압되지 않고 웨지(30)에만 밀착된 상태로 이송된다. However, in this embodiment, the depressurization unit 24 is provided only on the side of the second die roll 20 and is not provided on the side of the first die roll 10. That is, as will be described below, the first film 2 is not decompressed by a separate decompression unit and is transferred in close contact with only the wedge 30.
웨지(30)는 한 쌍의 다이롤(10,20)이 서로 간섭되지 않고 회전할 수 있도록 하부 양쪽에 오목한 곡면을 대칭적으로 갖는 쐐기형상으로 형성된다. The wedge 30 is formed in a wedge shape having concave curved surfaces symmetrically on both sides of the lower portion so that the pair of die rolls 10 and 20 can rotate without interfering with each other.
도 2를 참조하면, 정제 공급부(32)는 제2 필름(4)이 내면에 밀착된 제2 캡슐홈(22)으로 정제(40)를 공급한다. 정제 공급부(32)는 웨지(30)를 상하 방향으로 관통하여 형성되는 것으로서, 제2 다이롤(20) 쪽에 인접하게 배치될 수 있다. 정제 공급부(32)는 본 도면에서 일 예로 제시한 것에 불과하고 웨지(30)를 관통하여 설치될 수도 있고, 웨지(30)의 하면 부분에 별도로 설치되어 정제(40)를 공급할 수도 있다. Referring to FIG. 2, the tablet supply unit 32 supplies the tablet 40 to the second capsule groove 22 in which the second film 4 is in close contact with the inner surface. The tablet supply unit 32 is formed to penetrate the wedge 30 in the vertical direction and may be disposed adjacent to the second die roll 20 side. The tablet supply unit 32 is only shown as an example in this drawing and may be installed through the wedge 30, or may be separately installed on the lower surface of the wedge 30 to supply the tablet 40.
한편, 정제 공급부(32)를 통해 공급되는 정제(40)는 고형 제형에 해당하는 것으로서 통상의 정제와 이와 유사한 모든 고형 제형을 의미한다. 예를 들어, 정제(40)는 코팅정, 펠렛, 마이크로캡슐, 서방성 고형제, 속방성 고형제, 코어쉘타입 고형제 등이 사용될 수 있다. On the other hand, the tablet 40 supplied through the tablet supply unit 32 corresponds to a solid dosage form and means all solid dosage forms similar to that of a conventional tablet. For example, the tablet 40 may be a coated tablet, a pellet, a microcapsule, a sustained-release solid agent, an immediate-release solid agent, a core-shell type solid agent, or the like.
이하에서는 도 3 내지 도 6을 참조하여 약액 주입노즐에 대하여 설명하기로 한다. 도 3은 제1 약액 주입노즐에서 제1 필름으로 약액을 주입하는 것을 보인 도면이고, 도 4는 제1 필름으로 주입되는 약액의 용량 차이를 보인 도면이며, 도 5는 제1 캡슐홈의 다른 실시예를 보인 도면이고, 도 6은 웨지에 형성된 제2 약액 주입노즐 및 약액 배출부를 보인 도면이다. 본 실시예에서 약액 주입노즐(34,35)은, 상기 제1 캡슐홈(12)으로 약액을 주입하여 상기 제1 필름(2)이 약액의 용량만큼 요입되게 하는 제1 약액 주입노즐(34); 및 상기 제2 캡슐홈(22)의 내면에 밀착된 상기 제2 필름(4)으로 약액을 주입하는 제2 약액 주입노즐(35)을 포함할 수 있다. 이하에서는 약액 주입노즐(34,35)이 2개로 구성되어 각각의 캡슐홈(12,22)으로 약액이 주입되는 것으로 설명하겠으나, 이에 제한되는 것은 아니고 약액 주입노즐(34,35)이 하나로 구성되어 각각의 캡슐홈(12,22)으로 약액을 주입하는 구성도 가능할 것이다. Hereinafter, the chemical injection nozzle will be described with reference to FIGS. 3 to 6. 3 is a view showing the injection of a chemical solution from the first chemical injection nozzle to the first film, FIG. 4 is a view showing the difference in volume of the chemical solution injected into the first film, and FIG. 5 is another implementation of the first capsule groove It is a view showing an example, and FIG. 6 is a view showing a second chemical solution injection nozzle and a chemical solution discharge part formed in a wedge. In this embodiment, the chemical liquid injection nozzle 34, 35 is a first chemical liquid injection nozzle 34 that injects a chemical liquid into the first capsule groove 12 so that the first film 2 is concaved by the amount of the chemical liquid. ; And a second chemical solution injection nozzle 35 for injecting a chemical solution into the second film 4 in close contact with the inner surface of the second capsule groove 22. Hereinafter, it will be described that the chemical solution injection nozzles 34 and 35 are composed of two and the chemical solution is injected into each of the capsule grooves 12 and 22, but is not limited thereto, and the chemical solution injection nozzles 34 and 35 are configured as one. It will be possible to inject a chemical solution into each of the capsule grooves 12 and 22.
도 3을 참조하면, 제1 약액 주입노즐(34)은 웨지(30)의 중앙부를 상하 방향으로 관통하여 설치됨으로써, 제1 다이롤(10)에 의해 이송된 제1 필름(2)으로 약액을 주입한다. 이때, 제1 필름(2)은 상술한 바와 같이 별도의 감압부에 의하여 감압되지 않고 웨지(30)에 밀착된 상태로 이송된다. Referring to FIG. 3, the first chemical injection nozzle 34 is installed by penetrating the central portion of the wedge 30 in the vertical direction, so that the chemical solution is transferred to the first film 2 transferred by the first die roll 10. Inject. At this time, as described above, the first film 2 is not decompressed by a separate decompression unit and is transferred in close contact with the wedge 30.
이와 같이 이송된 제1 필름(2)으로 제1 약액 주입노즐(34)에서 약액을 주입한다. 그러면, 제1 약액 주입노즐(34)에서 분사되는 약액의 분사력에 의하여 제1 필름(2)은 제1 캡슐홈(12)으로 소정 깊이만큼 요입된다. 예를 들어, 제1 약액 주입노즐(34)에서는 연질캡슐(50) 전체에 수용된 약액의 절반에 해당하는 약액만큼 제1 필름(2) 쪽으로 주입하게 된다. A chemical solution is injected from the first chemical solution injection nozzle 34 into the first film 2 transferred as described above. Then, the first film 2 is concaved into the first capsule groove 12 by a predetermined depth by the injection force of the chemical liquid injected from the first chemical injection nozzle 34. For example, in the first chemical injection nozzle 34, a chemical solution corresponding to half of the chemical solution accommodated in the entire soft capsule 50 is injected toward the first film 2.
이때, 최종적으로 제조된 연질캡슐(50)의 전체 용량이 필름의 두께, 장치의 공차 등에 의하여 작게 되면 연질캡슐(50)에 수용된 약액의 용량을 조절할 필요가 있다. 작업자는 이 경우 도 4의 (b)에 도시된 바와 같이 약액의 용량을 작게 조절하여 주입할 수 있다. 결과적으로 연질캡슐의 제조에 있어 제품의 편차를 최대한 줄이고 신뢰도 있는 제품을 대량으로 생산할 수 있는 장점이 있다. At this time, if the total capacity of the finally manufactured soft capsule 50 is reduced by the thickness of the film and the tolerance of the device, it is necessary to adjust the capacity of the chemical solution contained in the soft capsule 50. In this case, as shown in (b) of FIG. 4, the operator can inject by adjusting the volume of the chemical solution small. As a result, in the manufacture of soft capsules, there is an advantage of reducing product deviation as much as possible and producing reliable products in large quantities.
이를 위하여 제1 캡슐홈(12)은 도 4의 (a)와 같이 바닥면과 측벽이 직각을 이루도록 형성될 수 있다. 즉, 제1 캡슐홈(12)의 종단면이 사각형을 이루도록 형성될 수 있다. 이와 같이 제1 캡슐홈(12)이 형성되면 실제 제조되는 연질캡슐(50)의 절반(반원형)보다 부피가 크기 때문에 약액을 많게 주입해도 제1 필름(2) 내에 약액이 원활하게 주입될 수 있다. To this end, the first capsule groove 12 may be formed such that the bottom surface and the sidewall form a right angle as shown in FIG. 4A. That is, the longitudinal section of the first capsule groove 12 may be formed to form a square. When the first capsule groove 12 is formed in this way, the volume is larger than the half (semicircle) of the soft capsule 50 that is actually manufactured, so even if a large amount of the chemical is injected, the chemical can be smoothly injected into the first film 2 .
또한, 제1 캡슐홈(12)은 도 5와 같이 바닥면과 측벽이 만나는 모서리 부분이 곡면을 이루도록 형성될 수 있다. 즉, 제1 캡슐홈(12)은 종단면이 U자형을 이루도록 형성될 수 있다. 이와 같이 제1 캡슐홈(12)이 형성되면 모서리 부분 쪽으로 약액이 보다 매끄럽게 주입되어 연질캡슐(50) 형태를 갖추는 것이 용이해질 수 있다. In addition, the first capsule groove 12 may be formed such that a corner portion where the bottom surface and the side wall meet to form a curved surface as shown in FIG. 5. That is, the first capsule groove 12 may be formed to have a U-shaped longitudinal section. When the first capsule groove 12 is formed in this way, the chemical liquid is injected more smoothly toward the corner portion, so that it may be easier to have the soft capsule 50 shape.
다음으로, 도 6을 참조하면, 웨지(30)에는 제2 약액 주입노즐(35)이 관통하여 설치됨으로써, 제2 다이롤(20)에 의해 이송된 제2 필름(4) 쪽으로 약액을 주입한다. 제2 캡슐홈(22)의 가장자리에는 밀착된 제2 필름(4)을 절단하기 위한 절단부(미도시)가 형성된다. 결국 약액이 주입되는 부분을 통과한 제1 필름(2) 및 제2 필름(4)은 중앙(웨지(30)의 하단 부분)에서 서로 가열 밀봉됨으로써 최종적으로 정제(40) 및 약액을 포함하는 연질캡슐(50)이 만들어진다. Next, referring to FIG. 6, a second chemical solution injection nozzle 35 is installed through the wedge 30, thereby injecting the chemical solution toward the second film 4 transferred by the second die roll 20. . A cutting part (not shown) for cutting the second film 4 in close contact is formed at the edge of the second capsule groove 22. Eventually, the first film 2 and the second film 4 passing through the portion where the chemical solution is injected are heat-sealed with each other in the center (the lower part of the wedge 30), and finally, the soft material containing the tablet 40 and the chemical solution A capsule 50 is made.
한편, 웨지(30)에는 약액이 주입되는 제2 약액 주입노즐(35)뿐만 아니라 제2 약액 주입노즐(35)의 분사력에 의해 순환된 공기 또는 공기가 혼합된 약액이 약액 배출부(36)가 형성된다. 약액 배출부(36)는 제2 약액 주입노즐(35)과 마찬가지로 웨지(30)를 관통하여 설치되는 것으로서, 제2 약액 주입노즐(35)과 한 쌍(한 세트)으로 구성된다. 그리고, 제2 약액 주입노즐(35) 및 약액 배출부(36)는 한 세트로 구성되어 웨지(30)의 길이방향(전후방향)을 따라 복수개의 세트가 배치된다. 본 도면에서는 총 7개의 세트가 웨지(30)의 길이방향을 따라 배치되는데 이에 제한되는 것은 아니고 웨지(30)의 설계 조건에 따라 다양한 개수로 배치될 수 있다. 제2 약액 주입노즐(35) 및 약액 배출부(36)가 위와 같이 제2 다이롤(20)의 회전방향에 대하여 수직방향으로 배치되면, 제2 캡슐홈(22)의 크기만큼 공정시간을 늘릴 수 있다. On the other hand, in the wedge 30, not only the second chemical solution injection nozzle 35 into which the chemical solution is injected, but also the air circulated by the injection force of the second chemical solution injection nozzle 35, or the chemical solution mixed with air, the chemical solution discharge unit 36 Is formed. The chemical liquid discharge part 36 is installed through the wedge 30 like the second chemical liquid injection nozzle 35, and is composed of a second chemical liquid injection nozzle 35 and a pair (one set). Further, the second chemical solution injection nozzle 35 and the chemical solution discharge unit 36 are configured as a set, and a plurality of sets are disposed along the longitudinal direction (front and rear direction) of the wedge 30. In this drawing, a total of seven sets are arranged along the longitudinal direction of the wedge 30, but are not limited thereto, and may be arranged in various numbers according to the design conditions of the wedge 30. When the second chemical liquid injection nozzle 35 and the chemical liquid discharge part 36 are arranged in a vertical direction with respect to the rotational direction of the second die roll 20 as above, the process time can be increased by the size of the second capsule groove 22. I can.
그리고, 웨지(30)의 상면에는 제2 약액 주입노즐(35)로 약액을 주입하는 주입구(52) 및 약액 배출부(36)를 통해 공기 또는 약액이 배출되는 배출구(54)가 구비된다. In addition, the upper surface of the wedge 30 is provided with an injection port 52 for injecting a chemical solution through the second chemical solution injection nozzle 35 and an outlet 54 through which air or a chemical solution is discharged through the chemical solution discharge unit 36.
도 7을 참조하면, 제2 약액 주입노즐(35) 및 약액 배출부(36)는 한 쌍(한 세트)으로만 구성되지 않고, 1개의 제2 약액 주입노즐(35)과 2개의 약액 배출부(36), 또는 2개의 제2 약액 주입노즐(35)과 1개의 약액 배출부(36)가 길이방향을 따라 배치될 수도 있다. 물론, 이와 같이 제2 약액 주입노즐(35) 및 약액 배출부(36)가 배치될 경우에는 제2 약액 주입노즐(35)과 약액 배출부(36)가 제2 캡슐홈(22)의 중심선에 대하여 대칭되게 배치될 필요는 없다. 이와 같이 배치되면, 약액의 공급이 많이 필요하거나 약액의 배출이 효과적으로 이루어져야 할 경우에 보다 원활하게 약액의 공급 및 배출이 이루어질 수 있다.Referring to FIG. 7, the second chemical liquid injection nozzle 35 and the chemical liquid discharge part 36 are not composed of only a pair (one set), but a second chemical liquid injection nozzle 35 and two chemical liquid discharge parts (36) Alternatively, two second chemical solution injection nozzles 35 and one chemical solution discharge part 36 may be disposed along the longitudinal direction. Of course, when the second chemical solution injection nozzle 35 and the chemical solution discharge part 36 are arranged in this way, the second chemical solution injection nozzle 35 and the chemical solution discharge part 36 are located at the center line of the second capsule groove 22. It need not be arranged symmetrically with respect to. When arranged in this way, when a large supply of the chemical solution is required or when the chemical solution is to be discharged effectively, the supply and discharge of the chemical solution can be made more smoothly.
또한, 본 도면에서는 제2 약액 주입노즐(35)과 약액 배출부(36)가 1개 또는 2개로 구성되는 것만 도시하였으나, 이에 제한되는 것은 아니고 1개 또는 3개 이상이 배치될 수도 있고, 양자가 각각 복수개로 배치될 수도 있다. In addition, in this drawing, only one or two of the second chemical injection nozzle 35 and the chemical solution discharge part 36 are shown, but the present invention is not limited thereto, and one or three or more may be disposed, and both May be disposed in plurality, respectively.
도 8을 참조하면, 제2 약액 주입노즐(35)은 제2 캡슐홈(22)으로 약액을 주입하는데, 이때 제2 약액 주입노즐(35)은 제2 캡슐홈(22)의 중심선에 대하여 편심되게 배치되어 약액을 주입하는 것이 바람직하다. 이는 제2 약액 주입노즐(35)에서 약액을 편심되게 주입하도록 함으로써, 약액과 함께 제2 캡슐홈(22)에 공기를 순환시켜 배출시키기 위함이다.Referring to FIG. 8, the second chemical solution injection nozzle 35 injects the chemical solution into the second capsule groove 22, wherein the second chemical solution injection nozzle 35 is eccentric with respect to the center line of the second capsule groove 22. It is preferable to be arranged to inject a chemical solution. This is to discharge by circulating air in the second capsule groove 22 together with the chemical liquid by eccentrically injecting the chemical liquid from the second chemical liquid injection nozzle 35.
보다 구체적으로 설명하면, 약액을 주입하기 전 정제(40)가 공급되는 과정에서 정제(40)와 함께 공기가 제2 캡슐홈(22)으로 유입될 수 있다. 이와 같이 공기가 제2 캡슐홈(22)의 내부에 남아있게 되면 약액이 적정 용량만큼 주입될 수 없어 제조된 연질캡슐(50)의 품질이 저하될 수 있다. 따라서, 본 실시예에서는 약액을 주입하는 과정에서 제2 약액 주입노즐(35)을 편심 배치함으로써 제2 캡슐홈(22)의 내부 잔존공기를 순환시켜 배출시키도록 구성하였다. In more detail, air may flow into the second capsule groove 22 together with the tablet 40 in the process of supplying the tablet 40 before injecting the chemical solution. As such, if the air remains inside the second capsule groove 22, the chemical liquid cannot be injected in an appropriate amount, and thus the quality of the manufactured soft capsule 50 may be deteriorated. Accordingly, in the present embodiment, the second chemical solution injection nozzle 35 is eccentrically disposed in the process of injecting the chemical solution, thereby circulating and discharging the remaining air inside the second capsule groove 22.
이상에서 설명한 제2 약액 주입노즐(35)의 분사력에 의해 순환된 공기 또는 공기가 혼합된 약액은 최대한 이격되게 배치된 약액 배출부(36)를 통해 외부로 배출될 수 있다. 약액 배출부(36)는 제2 캡슐홈(22)의 중심선에 대하여 제2 약액 주입노즐(35)과 대칭되게 배치되는 것으로서, 제2 캡슐홈(22)의 내부를 순환한 공기가 배출될 수 있도록 한다. The air circulated by the injection force of the second chemical liquid injection nozzle 35 described above or a chemical liquid mixed with air may be discharged to the outside through the chemical liquid discharge unit 36 arranged to be spaced apart as much as possible. The chemical liquid discharge part 36 is disposed symmetrically with the second chemical liquid injection nozzle 35 with respect to the center line of the second capsule groove 22, and the air circulating inside the second capsule groove 22 can be discharged. To be.
한편, 약액 배출부(36)의 입구에는 공기 또는 공기가 혼합된 약액이 배출되고 주입된 정제(40)는 통과하지 못하도록 분리필터(38)가 설치될 수 있다. 분리필터(38)로는 다공질을 갖는 합성수지나 폴리썰폰(Polysulfone), 폴리프로필렌(Polypropylene), 실리콘폴리머(Silicone Polymers), 폴리에스터(Polyester), 폴리테프론 에틸렌(Polytetrafluoro ethylene), 셀롤로스 아세테이트(Cellulose acetate), 폴리아크릴로니트릴(Polyacrylonitrile), 스테인리스 스틸, 철, 황동, 나일론(Nylon) 등의 소재 중 하나가 사용될 수 있다. 즉, 분리필터(38)는 주입된 정제(40)가 유출되는 것은 방지하면서 내부의 공기를 외부로 배출하도록 구성되는 것이다.Meanwhile, a separation filter 38 may be installed at an inlet of the chemical liquid discharge unit 36 so that air or a chemical liquid mixed with air is discharged and the injected tablet 40 does not pass. The separation filter 38 includes a porous synthetic resin, polysulfone, polypropylene, silicone polymers, polyester, polytetrafluoro ethylene, and cellulose acetate. ), polyacrylonitrile, stainless steel, iron, brass, nylon, and the like may be used. That is, the separation filter 38 is configured to discharge the air inside while preventing the injected tablet 40 from flowing out.
이상에서 설명한 구성을 가진 연질캡슐 제조 장치에 따르면, 제1 필름(2) 및 제2 필름(4)은 제1 다이롤(10) 및 제2 다이롤(20)의 상면 양측에서 각각 공급되고, 각각은 제1 다이롤(10) 및 제2 다이롤(20)의 적어도 일면에 감아진 상태로 중앙으로 회전되면서 이송된다.According to the soft capsule manufacturing apparatus having the configuration described above, the first film 2 and the second film 4 are supplied from both sides of the upper surface of the first die roll 10 and the second die roll 20, respectively, Each of the first die roll 10 and the second die roll 20 is wound around at least one surface and is rotated to the center and conveyed.
이때, 제1 필름(2) 및 제2 필름(4)은 상부에 배치된 웨지(30)에 의해 제1 다이롤(10) 및 제2 다이롤(20)에 밀착된다. 다음으로, 감압부(14)는 제2 캡슐홈(22)의 내부를 감압시키고 이에 의하여 제2 필름(4)은 제2 캡슐홈(22)의 내면에 밀착된다.At this time, the first film 2 and the second film 4 are in close contact with the first die roll 10 and the second die roll 20 by the wedge 30 disposed thereon. Next, the depressurization unit 14 decompresses the inside of the second capsule groove 22 and thereby the second film 4 is in close contact with the inner surface of the second capsule groove 22.
상기에서는 본 발명의 특정의 실시예를 참조하여 설명하였지만, 해당 기술 분야에서 통상의 지식을 가진 자라면 하기의 특허 청구의 범위에 기재된 본 발명의 사상 및 영역으로부터 벗어나지 않는 범위 내에서 본 발명을 다양하게 수정 및 변경시킬 수 있음을 이해할 수 있을 것이다.Although the above has been described with reference to specific embodiments of the present invention, those of ordinary skill in the relevant technical field may vary the present invention within the scope not departing from the spirit and scope of the present invention described in the following claims. You will understand that it can be modified and changed.
예를 들어, 제2 약액 주입노즐(35)을 편심 배치하는 구성은 웨지(30)에 의해 필름(2,4)이 눌려진 후 정제(40)를 공급하는 실시예를 통하여 설명하였으나, 이에 제한되지 않고 연질캡슐을 제조하는 공정에서 캡슐홈(12,22) 내부의 잔존공기를 배출시키는 방법으로 사용될 수 있다. 즉, 제2 약액 주입노즐(35)이 반드시 제2 다이롤(20) 측에만 배치되지 않고 제1 다이롤(10) 측에도 배치되어 제1 캡슐홈(12) 내부의 잔존공기를 배출시킬 수도 있는 것이다.For example, the configuration in which the second chemical injection nozzle 35 is eccentrically disposed has been described through the embodiment of supplying the tablet 40 after the films 2 and 4 are pressed by the wedge 30, but is not limited thereto. It can be used as a method of discharging the residual air inside the capsule grooves 12 and 22 in the process of manufacturing the soft capsule without. That is, the second chemical liquid injection nozzle 35 is not necessarily disposed only on the side of the second die roll 20, but is also disposed on the side of the first die roll 10 to discharge the remaining air inside the first capsule groove 12. will be.
<부호의 설명><Explanation of code>
2: 제1 필름 2: the first film
4: 제2 필름4: second film
10: 제1 다이롤10: first die roll
12: 제1 캡슐홈12: first capsule groove
20: 제2 다이롤20: second die roll
22: 제2 캡슐홈22: second capsule groove
24: 감압부24: decompression unit
30: 웨지30: wedge
32: 정제 공급부32: tablet supply unit
34: 제1 약액 주입노즐34: first chemical solution injection nozzle
35: 제2 약액 주입노즐35: second chemical liquid injection nozzle
36: 약액 배출부36: chemical liquid discharge unit
38: 분리필터38: separation filter
40: 정제40: tablet
50: 연질캡슐50: soft capsule
52 : 주입구52: inlet
54 : 배출구54: outlet

Claims (12)

  1. 적어도 일면에 제1 필름이 감아진 상태로 상기 제1 필름을 공급하고, 외주면을 따라 복수개의 제1 캡슐홈이 형성되는 제1 다이롤;A first die roll supplying the first film with the first film wound on at least one surface, and having a plurality of first capsule grooves formed along an outer circumferential surface thereof;
    상기 제1 다이롤에 인접하게 배치되고, 적어도 일면에 제2 필름이 감아진 상태로 상기 제2 필름을 공급하며, 외주면을 따라 복수개의 제2 캡슐홈이 형성되는 제2 다이롤;A second die roll disposed adjacent to the first die roll, supplying the second film with a second film wound on at least one surface thereof, and having a plurality of second capsule grooves formed along an outer circumferential surface thereof;
    상기 제1 다이롤 및 제2 다이롤의 일면에 감아진 상기 제 1 필름 및 제2 필름에 밀착되게 설치되는 웨지;A wedge installed in close contact with the first film and the second film wound on one surface of the first die roll and the second die roll;
    상기 제1 캡슐홈 또는 제2 캡슐홈을 감압하여 상기 제1 필름 또는 제2 필름이 내면에 밀착되게 하는 감압부;A depressurization unit for depressurizing the first capsule groove or the second capsule groove so that the first film or the second film is in close contact with the inner surface;
    상기 제1 캡슐홈 또는 제2 캡슐홈으로 정제를 공급하는 정제 공급부; 및A tablet supply unit for supplying tablets to the first capsule groove or the second capsule groove; And
    상기 제1 캡슐홈 및 제2 캡슐홈으로 약액을 주입하여 연질캡슐을 성형하는 약액 주입노즐을 포함하고,Injecting a chemical solution into the first capsule groove and the second capsule groove to form a soft capsule, and
    상기 약액 주입노즐 중 적어도 하나는 분사력으로 상기 제1 캡슐홈 또는 제2 캡슐홈의 내부 공기 및 약액을 순환시키는 것을 특징으로 하는 연질캡슐 제조 장치.At least one of the chemical injection nozzles circulates the internal air and the chemical liquid in the first capsule groove or the second capsule groove by spraying force.
  2. 제1항에 있어서,The method of claim 1,
    상기 약액 주입노즐의 주변에는 상기 순환된 내부 공기 또는 공기가 혼합된 약액이 배출되는 약액 배출부가 설치되는 것을 특징으로 하는 연질캡슐 제조 장치.A soft capsule manufacturing apparatus, characterized in that a chemical liquid discharge part through which the circulated internal air or a chemical liquid mixed with air is discharged is installed around the chemical liquid injection nozzle.
  3. 제2항에 있어서,The method of claim 2,
    상기 약액 배출부는 상기 제1 캡슐홈 또는 제2 캡슐홈의 중심선에 대하여 상기 약액 주입노즐과 대칭되게 배치되는 것을 특징으로 하는 연질캡슐 제조 장치. The soft capsule manufacturing apparatus, wherein the chemical liquid discharge part is disposed symmetrically with the chemical liquid injection nozzle with respect to a center line of the first capsule groove or the second capsule groove.
  4. 제2항에 있어서,The method of claim 2,
    상기 약액 배출부의 입구에는 약액만 배출되고 상기 정제는 통과하지 못하도록 분리필터가 설치되는 것을 특징으로 하는 연질캡슐 제조 장치.A device for producing soft capsules, characterized in that a separation filter is installed at the inlet of the chemical liquid discharge part to discharge only the chemical liquid and prevent the tablet from passing through.
  5. 제1항에 있어서,The method of claim 1,
    상기 제1 캡슐홈은 바닥면과 측벽이 만나는 모서리 부분이 곡면을 이루도록 형성되는 것을 특징으로 하는 연질캡슐 제조 장치. The first capsule groove is a soft capsule manufacturing apparatus, characterized in that formed so as to form a curved surface edge portion where the bottom surface and the side wall meet.
  6. 제1항에 있어서,The method of claim 1,
    상기 약액 주입노즐은,The chemical solution injection nozzle,
    상기 제1 캡슐홈으로 약액을 주입하여 상기 제1 필름이 약액의 용량만큼 요입되게 하는 제1 약액 주입노즐; 및A first chemical liquid injection nozzle for injecting a chemical liquid into the first capsule groove so that the first film is concaved by the amount of the chemical liquid; And
    상기 제2 캡슐홈의 내면에 밀착된 상기 제2 필름으로 약액을 주입하는 제2 약액 주입노즐을 포함하는 것을 특징으로 하는 연질캡슐 제조 장치. A soft capsule manufacturing apparatus comprising a second chemical solution injection nozzle for injecting a chemical solution into the second film in close contact with the inner surface of the second capsule groove.
  7. 제6항에 있어서,The method of claim 6,
    상기 제1 약액 주입노즐은 상기 웨지의 중앙을 관통하여 설치되는 것을 특징으로 하는 연질캡슐 제조 장치. The first chemical injection nozzle is a soft capsule manufacturing apparatus, characterized in that installed through the center of the wedge.
  8. 제6항에 있어서,The method of claim 6,
    상기 제2 약액 주입노즐은 상기 제2 캡슐홈의 중심선에 대하여 편심되게 배치되고, 분사력으로 상기 제2 캡슐홈의 내부 공기 및 약액을 순환시키는 것을 특징으로 하는 연질캡슐 제조 장치.The second chemical liquid injection nozzle is disposed eccentrically with respect to a center line of the second capsule groove, and circulates the air and the chemical liquid inside the second capsule groove with a spraying force.
  9. 제8항에 있어서,The method of claim 8,
    상기 제2 약액 주입노즐의 주변에는 상기 순환된 내부 공기 또는 공기가 혼합된 약액이 배출되는 약액 배출부가 설치되는 것을 특징으로 하는 연질캡슐 제조 장치.A soft capsule manufacturing apparatus, characterized in that a chemical liquid discharge part for discharging the circulated internal air or a chemical liquid mixed with air is installed around the second chemical liquid injection nozzle.
  10. 제9항에 있어서,The method of claim 9,
    상기 제2 약액 주입노즐 및 약액 배출부는 상기 웨지를 관통하여 설치되고, 상기 제2 약액 주입노즐 및 약액 배출부는 한 세트로 구성되어 상기 웨지의 길이방향을 따라 복수의 세트가 설치되는 것을 특징으로 하는 연질캡슐 제조 장치.The second chemical solution injection nozzle and the chemical solution discharge unit are installed through the wedge, and the second chemical solution injection nozzle and the chemical solution discharge unit are configured as a set, and a plurality of sets are installed along the longitudinal direction of the wedge. Soft capsule manufacturing device.
  11. 제9항에 있어서, The method of claim 9,
    상기 제2 약액 주입노즐 및 약액 배출부는 상기 웨지를 관통하여 설치되고, 상기 제2 약액 주입노즐 및 약액 배출부는 각각이 적어도 하나 이상으로 구성되어 상기 웨지의 길이방향을 따라 배치되는 것을 특징으로 하는 연질캡슐 제조 장치.The second chemical solution injection nozzle and the chemical solution discharge unit are installed through the wedge, and the second chemical solution injection nozzle and the chemical solution discharge unit are each composed of at least one and are arranged along the length direction of the wedge. Capsule manufacturing device.
  12. 제11항에 있어서, The method of claim 11,
    1개의 상기 제2 약액 주입노즐 및 2개의 상기 약액 배출부, 또는 2개의 상기 제2 약액 주입노즐 및 1개의 상기 약액 배출부가 한 세트로 구성되어 배치되는 것을 특징으로 하는 연질캡슐 제조 장치.One of the second chemical liquid injection nozzle and the two chemical liquid discharge parts, or the two second chemical liquid injection nozzle and the one said chemical liquid discharge part is a soft capsule manufacturing apparatus, characterized in that the configuration is arranged as a set.
PCT/KR2020/003624 2019-03-25 2020-03-17 Soft capsule manufacturing device WO2020197145A1 (en)

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