WO2020158071A1 - Ciment de verre ionomère liquide pour dentisterie, et ciment de verre ionomère - Google Patents

Ciment de verre ionomère liquide pour dentisterie, et ciment de verre ionomère Download PDF

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Publication number
WO2020158071A1
WO2020158071A1 PCT/JP2019/041656 JP2019041656W WO2020158071A1 WO 2020158071 A1 WO2020158071 A1 WO 2020158071A1 JP 2019041656 W JP2019041656 W JP 2019041656W WO 2020158071 A1 WO2020158071 A1 WO 2020158071A1
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WO
WIPO (PCT)
Prior art keywords
ionomer cement
glass ionomer
dental glass
acid
powder
Prior art date
Application number
PCT/JP2019/041656
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English (en)
Japanese (ja)
Inventor
裕介 島田
大三郎 森
Original Assignee
株式会社ジーシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社ジーシー filed Critical 株式会社ジーシー
Priority to JP2020569372A priority Critical patent/JPWO2020158071A1/ja
Publication of WO2020158071A1 publication Critical patent/WO2020158071A1/fr
Priority to JP2022184612A priority patent/JP2023009286A/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/15—Compositions characterised by their physical properties
    • A61K6/17—Particle size

Definitions

  • the present invention relates to a dental glass ionomer cement liquid used by mixing with a dental glass ionomer cement powder component containing aluminosilicate glass as a main component, and a dental glass ionomer cement.
  • Dental glass ionomer cement is used by reacting a polymer acid mainly composed of an acid such as polycarboxylic acid with glass powder for glass ionomer cement in the presence of water to cure.
  • Glass ionomer cement has an extremely good affinity for living organisms, and the cured product is semitransparent and has excellent aesthetics. Further, the glass ionomer cement has an excellent adhesive force to tooth substances such as enamel and dentin, and further, when the glass powder contains fluorine, the anti-caries action by the fluorine is exerted. It has excellent characteristics such as being present.
  • glass ionomer cement is widely used in the dental field for filling caries cavities, fusion of crown inlay bridges and orthodontic bands, lining of cavities, sealers for root canal filling, abutment construction and preventive filling. It is a material.
  • the form of dental glass ionomer cement is generally composed of a powder component containing fluoroaluminosilicate glass and a liquid component containing a polycarboxylic acid polymer (see, for example, Patent Document 1). This cement is used by mixing and kneading a powder component and a liquid component into a kneaded product, applying it to a treatment site, and then hardening it.
  • the powder component when mixing and kneading the powder component containing the aluminosilicate glass and the liquid component containing the polycarboxylic acid polymer. It is possible to increase the ratio of. However, when the ratio of the powder component is increased, the cement hardens too fast, and there is a problem that there is no time margin for clinical use. That is, it has been difficult to obtain a cement hardened product having high physical strength while ensuring an appropriate operating margin for clinical use.
  • an object of the present invention is to provide a dental glass ionomer cement liquid that can obtain a hardened cement with high physical strength while ensuring an appropriate operating margin for clinical use.
  • One aspect of the present invention is a dental glass ionomer cement liquid containing a polycarboxylic acid polymer, water, and a water reducing agent.
  • the dental glass ionomer cement liquid according to one aspect of the present invention, it is possible to obtain a cement hardened product having high physical strength while ensuring an appropriate operating margin for clinical use.
  • the dental glass ionomer cement liquid of the present embodiment has a polycarboxylic acid-based polymer, water, and a water reducing agent.
  • the polycarboxylic acid polymer is a component necessary for the reaction with the aluminosilicate glass powder contained in the powder component described later.
  • an acid-base reaction occurs in which the aluminum ion eluted from the aluminosilicate glass powder and the conjugate base of the polycarboxylic acid-based polymer undergo ionic cross-linking and are cured. ..
  • the polycarboxylic acid type polymer is a polymer of ⁇ - ⁇ unsaturated monocarboxylic acid or ⁇ - ⁇ unsaturated dicarboxylic acid.
  • ⁇ - ⁇ unsaturated monocarboxylic acid or ⁇ - ⁇ unsaturated dicarboxylic acid For example, one or more selected from acrylic acid, methacrylic acid, 2-chloroacrylic acid, 3-chloroacrylic acid, aconitic acid, mesaconic acid, maleic acid, itaconic acid, fumaric acid, glutaconic acid, and citraconic acid.
  • Examples of the polycarboxylic acid polymer include a copolymer or a homopolymer containing the same. You may use 2 or more types of these.
  • the polycarboxylic acid polymer preferably does not contain a polymerizable ethylenically unsaturated double bond.
  • the blending amount of the polycarboxylic acid polymer is preferably 5 to 60% by mass in the dental glass ionomer cement liquid.
  • the blending amount of the polycarboxylic acid-based polymer is 5% by mass or more, the dentin adhesion, which is a characteristic of a dental glass ionomer cement, is improved.
  • the blending amount of the polycarboxylic acid polymer is 60% by mass or less, the durability of the cured product is improved. More preferably, it is 20 to 50% by mass.
  • Water is a necessary component for acid-base reaction between aluminosilicate glass powder and polycarboxylic acid type polymer.
  • the water content may be the balance of the other components, but it is preferably 30 to 80% by mass in the dental glass ionomer cement liquid. When the amount of water is 30% by mass or more, the miscibility is improved. When the blending amount of water is 80% by mass or less, the physical strength of the cured product becomes high. More preferably, it is 40 to 70% by mass.
  • the water-reducing agent has the effect of preventing the cement from hardening too fast even if the ratio of the powder component is increased in the acid-base reaction by mixing and kneading the dental glass ionomer cement liquid and the powder component.
  • water reducing agent examples include lignin sulfonate-based, oxycarboxylate-based, naphthalene sulfonate-based, melamine sulfonate-based, polystyrene sulfonate-based, and polycarboxylate-based water reducing agents.
  • examples thereof include water reducing agents such as lignin sulfonate, oxycarboxylate, naphthalene sulfonate, melamine sulfonate, polystyrene sulfonate, and polycarboxylate.
  • the refractive index nd of the aluminosilicate glass powder is preferably in the range of 1.42 to 1.47.
  • the difference from the refractive index nd (about 1.42) of the matrix component of the dental glass ionomer cement that is practically useful is small, and the obtained cured dental glass ionomer cement is obtained. Transparency is increased.
  • At least one of the dental glass ionomer cement liquid of the present embodiment and the powder component can be appropriately blended with a contrast agent, an antibacterial agent, a fluorescent agent, a fragrance, a pigment, etc., if necessary.
  • the mass ratio (powder-liquid ratio) of the powder component to the dental glass ionomer cement liquid when preparing a kneaded product of the dental glass ionomer cement is preferably 1 to 5.
  • the powder-liquid ratio is 1 or more, the physical strength of the hardened dental cement is improved.
  • the powder-liquid ratio is 5 or less, the operability of the dental cement is improved.
  • a more preferable powder-liquid ratio is 3 to 4.5, and a further preferable powder-liquid ratio is 3.2 to 4.
  • Dental glass ionomer cement is used by mixing and kneading a powder component and a liquid component into a kneaded product, applying it to the treatment site, and then hardening it.
  • the time from the start of kneading until the shape of the kneading cannot be adjusted is defined as "operation allowance time”.
  • aluminosilicate glass powder ⁇ Preparation of aluminosilicate glass powder> Silica 27.5 g, alumina 12.7 g, aluminum fluoride 16.7 g, strontium fluoride 18.6 g, aluminum phosphate 8.8 g, sodium fluoride 4.2 g, potassium fluoride 5.6 g, lanthanum fluoride 5. 9 g was thoroughly mixed in a mortar. The obtained mixture was put in a magnetic crucible and allowed to stand in an electric furnace. After heating the electric furnace to melt at 1300° C. and homogenizing sufficiently, it was poured into water to obtain a lump of aluminosilicate glass.
  • aluminosilicate glass powder 100 parts by mass of 1% aluminum phosphate aqueous solution was mixed with 100 parts by mass of the aluminosilicate glass powder to prepare a slurry, which was dried at 120°C.
  • Polyacrylic acid powder (average molecular weight: 30,000) was mixed with the obtained powder in an amount of 3% by mass to obtain a powder component.
  • ⁇ Preparation of dental glass ionomer cement liquid The ingredients were mixed in the formulations shown in Table 1 to prepare dental glass ionomer cement solutions of Examples 1 to 13 and Comparative Examples 1 and 2. The unit of the blending amount is mass%.
  • Polyacrylic acid powder Polyacrylic acid powder having an average molecular weight of 25,000 (manufactured by FUJIFILM Wako Pure Chemical Industries) Melflux 5581F: Water-soluble salt of methacrylic acid-acrylic acid copolymer having polyoxyethylene chain having SKW East Asia Melflux 4930F: methacrylic acid having polyoxyethylene chain having acrylic acid and made of SKW East Asia Water-soluble salt of polymer Melment F4000: Water-soluble salt of copolymer of methacrylic acid and acrylic acid having polyoxyethylene chain manufactured by SKW East Asia ⁇ Operation allowance time>
  • a spatula was prepared by mixing the dental glass ionomer cement liquids of Examples 1 to 13 and Comparative Examples 1 and 2 and the powder components with the powder-liquid ratio shown in Table 1. Used and mixed for 30 seconds.
  • the kneaded product was filled in a stainless steel mold having a cavity of 2 mm ⁇ 2 mm ⁇ 25 mm, pressed with a glass plate through a cellophane, and taken out after 1 hour to obtain a prismatic cured product.
  • the obtained cured product was immersed in distilled water at 37° C. for 24 hours and then polished with a #320 water-resistant polishing paper to give a test sample.

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dental Preparations (AREA)

Abstract

L'invention concerne un ciment de verre ionomère liquide pour dentisterie qui comprend un polymère à base d'acide polycarboxylique, une eau, et un plastifiant réducteur d'eau.
PCT/JP2019/041656 2019-01-30 2019-10-24 Ciment de verre ionomère liquide pour dentisterie, et ciment de verre ionomère WO2020158071A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2020569372A JPWO2020158071A1 (ja) 2019-01-30 2019-10-24 歯科用グラスアイオノマーセメント液及び歯科用グラスアイオノマーセメント
JP2022184612A JP2023009286A (ja) 2019-01-30 2022-11-18 歯科用グラスアイオノマーセメント液及び歯科用グラスアイオノマーセメント

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019-013735 2019-01-30
JP2019013735 2019-01-30

Publications (1)

Publication Number Publication Date
WO2020158071A1 true WO2020158071A1 (fr) 2020-08-06

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JP (2) JPWO2020158071A1 (fr)
WO (1) WO2020158071A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52101893A (en) * 1976-02-24 1977-08-26 Nippon Kayaku Kk Liquid hardener for dental glass ionomer cement
JP2003183112A (ja) * 2001-12-17 2003-07-03 Gc Corp 歯科用ペースト系グラスアイオノマーセメント組成物
JP2007091607A (ja) * 2005-09-27 2007-04-12 Gc Corp 歯科用ペースト系グラスアイオノマーセメント組成物
JP2011506367A (ja) * 2007-12-14 2011-03-03 デンツプライ デトレイ ゲー．エム．ベー．ハー． 硬化組成物
JP2017061629A (ja) * 2015-09-25 2017-03-30 旭化成株式会社 粘性硬化剤組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013053075A (ja) * 2011-09-01 2013-03-21 Gc Corp 歯科用セメント組成物
JP6734659B2 (ja) * 2016-02-15 2020-08-05 株式会社松風 根管充填用シーラー組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52101893A (en) * 1976-02-24 1977-08-26 Nippon Kayaku Kk Liquid hardener for dental glass ionomer cement
JP2003183112A (ja) * 2001-12-17 2003-07-03 Gc Corp 歯科用ペースト系グラスアイオノマーセメント組成物
JP2007091607A (ja) * 2005-09-27 2007-04-12 Gc Corp 歯科用ペースト系グラスアイオノマーセメント組成物
JP2011506367A (ja) * 2007-12-14 2011-03-03 デンツプライ デトレイ ゲー．エム．ベー．ハー． 硬化組成物
JP2017061629A (ja) * 2015-09-25 2017-03-30 旭化成株式会社 粘性硬化剤組成物

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JPWO2020158071A1 (ja) 2021-09-30
JP2023009286A (ja) 2023-01-19

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