WO2020107226A1 - 一种中药组合物及其制备方法以及应用 - Google Patents

一种中药组合物及其制备方法以及应用 Download PDF

Info

Publication number
WO2020107226A1
WO2020107226A1 PCT/CN2018/117738 CN2018117738W WO2020107226A1 WO 2020107226 A1 WO2020107226 A1 WO 2020107226A1 CN 2018117738 W CN2018117738 W CN 2018117738W WO 2020107226 A1 WO2020107226 A1 WO 2020107226A1
Authority
WO
WIPO (PCT)
Prior art keywords
parts
chinese medicine
traditional chinese
medicine composition
ginseng
Prior art date
Application number
PCT/CN2018/117738
Other languages
English (en)
French (fr)
Inventor
刘志杰
Original Assignee
深圳市得道健康管理有限公司
刘志杰
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳市得道健康管理有限公司, 刘志杰 filed Critical 深圳市得道健康管理有限公司
Priority to PCT/CN2018/117738 priority Critical patent/WO2020107226A1/zh
Priority to CN201880028278.6A priority patent/CN111491647A/zh
Publication of WO2020107226A1 publication Critical patent/WO2020107226A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, its preparation method and application.
  • the technical problem to be solved by the present invention is to treat the above-mentioned diseases caused by evil heat in the human body.
  • the present invention provides a traditional Chinese medicine composition prepared by the following proportions of traditional Chinese medicine raw materials in parts by weight: chicken yellow 1-3 pieces, donkey-hide gelatin 5-60 parts, berberine 15- 75 servings, 10-50 servings of Scutellaria baicalensis, 10-50 servings of Paeonia lactiflora, 5-45 servings of ginseng, and 15-45 servings of licorice root.
  • the further technical solution is as follows: based on parts by weight, prepared from the following combination of traditional Chinese medicine raw materials: chicken yellow 2-3 pieces, donkey-hide gelatin 35-59 parts, Coptis chinensis 53-73 parts, scutellaria root 30-47 parts, peony 35-48 parts , 31-40 servings of ginseng and 29-43 servings of licorice root.
  • a further technical solution is as follows: based on parts by weight, prepared from the combination of the following traditional Chinese medicine raw materials: 2 chicken yellows, 45 parts of donkey-hide gelatin, 60 parts of Coptis chinensis, 30 parts of scutellaria root, 30 parts of paeonia, 30 parts of ginseng, and 30 parts of licorice root.
  • the present invention also provides a method for preparing a Chinese medicine composition as described in the first aspect, including the following steps:
  • a further technical solution is: in the step S1, the mass ratio of the raw material of traditional Chinese medicine to water is 1:9-11, and the soaking time is 20-40 min.
  • a further technical solution is: in the step S2, first heat to boiling, and then continue to cook for 60-90 min at 100-115°C.
  • a further technical solution is that: in the step S3, the final amount of medicinal juice obtained is 1/5-3/5 of the volume of water added.
  • step S4 the gelatin is powdered.
  • the present invention provides the use of the traditional Chinese medicine composition as described in the first aspect in the preparation of a medicine for clearing away heat, removing dryness, and nourishing blood and stopping profits.
  • the traditional Chinese medicine composition disclosed by the invention has the functions of clearing away heat and removing dryness, nourishing blood and stopping profits.
  • the above-mentioned components cooperate with each other according to the compatibility relationship of "Jun, Chen, Zuo, Shi", and synergistically aim at the body heat caused by evil heat without sweating or sweating, thirst, irritability, or irritability and insomnia, skin heat Dryness and epilepsy, or external jaundice, or seeing urgency and urgency, even dysentery, pure blood, dozens of lines a day, the skin is thin as firewood, angst in the abdomen, the pain is like a knife stab, or constipation has obvious symptoms Healing effect or relief effect. Suitable for clinical application.
  • FIG. 1 is a flowchart of a method for preparing a traditional Chinese medicine composition provided by an embodiment of the present invention.
  • the embodiment of the present invention provides a traditional Chinese medicine composition.
  • Chicken yellow, donkey-hide gelatin, Coptis chinensis, scutellaria root, paeonia lactiflora, ginseng, and licorice root are selected as raw materials of traditional Chinese medicine.
  • chicken yellow has the effect of nourishing yin and moisturizing, nourishing blood and quenching wind.
  • Ejiao has the effect of nourishing yin and nourishing blood and restoring the fetus. It can cure blood deficiency, labor cough, hematemesis, epistaxis, bloody stool.
  • Coptis chinensis has the effects of clearing away heat and dampness, purging fire and detoxifying.
  • Scutellaria has the effects of clearing away heat and dampness, purging fire and detoxifying, hemostasis, and relieving fetus.
  • Paeonia lactiflora has the effects of antispasmodic, analgesic and menstrual.
  • Ginseng has the functions of nourishing vital energy, replenishing the veins, solidifying the spleen, nourishing the spleen and lungs, regenerating the body and soothing the nerves.
  • Roasted licorice has the effect of nourishing qi and nourishing yin, and Tongyang Fumai.
  • This embodiment provides a traditional Chinese medicine composition, which includes one chicken yellow, 15 g of donkey-hide gelatin, 20 g of Coptis chinensis, 10 g of Scutellaria baicalensis, 20 g of Paeonia lactiflora, 10 g of ginseng, and 15 g of licorice root.
  • This embodiment also provides a method for preparing a traditional Chinese medicine composition, which includes the following steps:
  • the above-mentioned traditional Chinese medicine composition can be used for preparing medicines for clearing away heat and removing dryness, nourishing blood and stopping profits.
  • This embodiment provides a traditional Chinese medicine composition, which includes 2 chicken yellows, donkey-hide gelatin 45g, berberine 60g, scutellaria root 30g, paeonia lactiflora 30g, ginseng 30g, roasted licorice 30g.
  • This embodiment also provides a method for preparing a traditional Chinese medicine composition, which includes the following steps:
  • the above-mentioned traditional Chinese medicine composition can be used for preparing medicines for clearing away heat and removing dryness, nourishing blood and stopping profits.
  • This embodiment provides a traditional Chinese medicine composition, which includes three chicken yellows, donkey-hide gelatin 60g, berberine 75g, scutellaria root 50g, peony root 50g, ginseng 45g, and licorice root 45g.
  • This embodiment also provides a method for preparing a traditional Chinese medicine composition, which includes the following steps:
  • the above-mentioned traditional Chinese medicine composition can be used for preparing medicines for clearing away heat and removing dryness, nourishing blood and stopping profits.
  • This embodiment provides a traditional Chinese medicine composition, which includes 2 chicken yellows, 25 g of donkey-hide gelatin, 15 g of Coptis chinensis, 30 g of scutellaria root, 10 g of peony root, 5 g of ginseng, and 20 g of licorice root.
  • This embodiment also provides a method for preparing a traditional Chinese medicine composition, which includes the following steps:
  • the above-mentioned traditional Chinese medicine composition can be used for preparing medicines for clearing away heat and removing dryness, nourishing blood and stopping profits.
  • the present invention also provides the traditional Chinese medicine compositions of Examples 5-10.
  • the traditional Chinese medicine composition can be used to prepare medicines for clearing away heat, removing dryness, and nourishing blood and stopping bleeding.
  • Table 1 The Chinese medicine composition provided by Examples 5-10
  • Subjects A total of 845 patients, including 467 male patients and 378 female patients, with an age distribution between 9 and 60 years old. All patients had thermal dysentery or even bloody dysentery caused by fire poisoning, and the clinical manifestations were No sweat or less sweat, thirst, irritability, or irritability, or insomnia, hot and dry skin and anxiety, and even dysentery, pure blood, dozens of lines per day, thin as wood, twisted in the abdomen Anxious, painful like a knife.
  • Treatment Take the Chinese medicine composition juice in the scheme of Example 1 of the present invention, take it three times in the morning, middle and evening, each time taking 150-350ml, warmly take Qihe, and observe the clinical efficacy.
  • Criteria for curative effect 1) cured, symptoms and signs completely disappeared; 2) markedly effective, most symptoms and signs disappeared after treatment; 3) ineffective, symptoms and signs have not been relieved or even aggravated.
  • the Chinese medicine composition in this scheme under the mutual cooperation and synergy of each specific compatible Chinese herbal medicine component, has the functions of heat removing dryness and nourishing in curing or alleviating the related diseases caused by warm evils.
  • the obvious curative effect of Xuezhili is suitable for clinical application.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

一种中药组合物及其制备方法以及应用，该中药组合物由以下配比的中药原料制得：鸡子黄1-3枚、阿胶5-60克、黄连15-75克、黄芩10-50克、芍药10-50克、人参5-45克、炙甘草15-45克。该中药组合物具有清热除燥，养血止利的功效。针对因火毒内盛所导致的热性痢疾甚至是血性痢疾，身热无汗或少汗，口干渴，心中烦躁不安，或烦躁失眠，便秘等症状具有明显的治愈效果或缓解功效。

Description

一种中药组合物及其制备方法以及应用 技术领域
本发明涉及中药领域，尤其是指一种中药组合物及其制备方法以及应用。
背景技术
邪热，可导致人体内部机能失调，阳气不能敛降而外发，主要症状有身热无汗或少汗，口干渴，心中烦躁不安，或烦躁失眠，肌肤热燥而衄，或外发黄疸，或见里急下利，甚则痢下纯血，日数十行，蠃瘦如柴，腹中绞急，痛如刀刺，或便秘等。而现有的中药复方中，并没有针对人体因邪热引起的躁热、无汗、口干等拥有显著疗效的中药组合物。
发明内容
本发明所要解决的技术问题是：治疗人体因邪热引起的上述病症。
为了解决上述技术问题，第一方面，本发明提供一种中药组合物，按重量份计，由以下配比的中药原料制得：鸡子黄1-3枚、阿胶5-60份、黄连15-75份、黄芩10-50份、芍药10-50份、人参5-45份、炙甘草15-45份。
其进一步地技术方案为：按重量份计，由以下中药原料组合制得：鸡子黄1-2枚、阿胶15-25份、黄连20-42份、黄芩14-28份、芍药15-32份、人参8-21份、炙甘草19-25份。
其进一步地技术方案为：按重量份计，由以下中药原料组合制得：鸡子黄2-3枚、阿胶35-59份、黄连53-73份、黄芩30-47份、芍药35-48份、人参31-40 份、炙甘草29-43份。
其进一步地技术方案为：按重量份计，由以下中药原料组合制得：鸡子黄2枚、阿胶45份、黄连60份、黄芩30份、芍药30份、人参30份、炙甘草30份。
第二方面，本发明还提供一种如第一方面所述的中药组合物的制备方法，包括如下步骤：
S1、按比例取黄连、黄芩、芍药、人参、炙甘草加水浸泡，得到混合物；
S2、煎煮S1中的混合物；
S3、过滤，除去药渣，得药汁；
S4、将阿胶加入药汁中充分烊化，再加入鸡子黄，搅拌均匀即得。
其进一步地技术方案为：所述S1步骤中，中药原料与水的质量比为1：9-11，浸泡时间为20-40min。
其进一步地技术方案为：所述S2步骤中，先加热至沸腾，然后在100-115℃下继续煎煮60-90min。
其进一步地技术方案为：所述S3步骤中，最终所得药汁量为加入水的体积的1/5-3/5。
其进一步地技术方案为：所述S4步骤中，阿胶为粉状。
第三方面，本发明提供一种如第一方面所述的中药组合物在制备清热除燥、养血止利的药物中的应用。
本发明所公开的中药组合物具有清热除燥、养血止利的功效。上述组分按照“君、臣、佐、使”的配伍关系相互配合，协同作用，针对因邪热导致的身 热无汗或少汗，口干渴，心中烦躁不安，或烦躁失眠，肌肤热燥而衄，或外发黄疸，或见里急下利，甚则痢下纯血，日数十行，蠃瘦如柴，腹中绞急，痛如刀刺，或便秘等症状具有明显的治愈效果或缓解功效。适合临床应用。
附图说明
为了使本发明的内容更容易被清楚的理解，下面根据本发明的具体实施例并结合附图，对本发明作进一步详细的说明。
图1是本发明实施例提供的中药组合物的制备方法流程图。
具体实施方式
为详细说明本发明的技术内容、构造特征、所实现目的及效果，以下结合实施方式详予说明。
本发明实施例提供一种中药组合物，选择鸡子黄、阿胶、黄连、黄芩、芍药、人参、炙甘草为中药原料。其中鸡子黄具有滋阴润燥，养血熄风之功效。阿胶具有滋阴补血，安胎的功效。可治血虚，虚劳咳嗽，吐血，衄血、便血。黄连具有清热燥湿，泻火解毒的功效。可治疗湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄。黄芩具有有清热燥湿、泻火解毒、止血、安胎等功效。芍药具有具有镇痉、镇痛、通经的功效。人参具有大补元气，复脉固脱，补脾益肺，生津，安神等功效，可治疗一切气血津液不足之证。炙甘草具有益气滋阴，通阳复脉治疗功效。上述7种中药原料按照“君、臣、佐、使”的配伍关系相互配合，协同作用，可以使该中药组合物用于治疗因热引起的口干、烦躁等，病人往往身热无汗口干渴，甚至因血热妄行而出血。 干姜为大热之药，若使用干姜，只会以温增热，加重病情，更伤津血；宜使用具有益气滋阴的炙甘草，护胃气养津液。故本发明提供的中药组合物中，不添加干姜。
具体实施例如下：
实施例1
本实施例提供一种中药组合物，所述中药组合物中包括鸡子黄1枚、阿胶15g、黄连20g、黄芩10g、芍药20g、人参10g、炙甘草15g。
本实施例还提供一种制备中药组合物的方法，其包括如下步骤：
S1、按比例取黄连、黄芩、芍药、人参、炙甘草加水675ml浸泡20min，得到混合物，其中，人参为切片处理后得到；
S2、煎煮S1中的混合物，先大火加热至沸腾，然后转小火，在100℃下继续煎煮90min；
S3、关火，过滤，除去药渣，得药汁405ml；
S4、将阿胶打成粉状加入上述药汁中充分烊化，再加入鸡子黄1枚，搅拌均匀即得中药组合物。
上述的中药组合物可用于制备清热除燥、养血止利的药物。
实施例2
本实施例提供一种中药组合物，所述中药组合物中包括鸡子黄2枚、阿胶45g、黄连60g、黄芩30g、芍药30g、人参30g、炙甘草30g。
本实施例还提供一种制备中药组合物的方法，其包括如下步骤：
S1、按比例取黄连、黄芩、芍药、人参、炙甘草加水1800ml浸泡30min， 得到混合物，其中，人参为切片处理后得到；
S2、煎煮S1中的混合物，先大火加热至沸腾，然后转小火，在115℃下继续煎煮80min；
S3、关火，过滤，除去药渣，得药汁900ml；
S4、将阿胶打成粉状加入上述药汁中充分烊化，再加入鸡子黄2枚，搅拌均匀即得中药组合物。
上述的中药组合物可用于制备清热除燥、养血止利的药物。
实施例3
本实施例提供一种中药组合物，所述中药组合物中包括鸡子黄3枚、阿胶60g、黄连75g、黄芩50g、芍药50g、人参45g、炙甘草45g。
本实施例还提供一种制备中药组合物的方法，其包括如下步骤：
S1、按比例取黄连、黄芩、芍药、人参、炙甘草加水2915ml浸泡40min，得到混合物，其中，人参为切片处理后得到；
S2、煎煮S1中的混合物，先大火加热至沸腾，然后转小火，在105℃下继续煎煮70min；
S3、关火，过滤，除去药渣，得药汁583ml；
S4、将阿胶打成粉状加入上述药汁中充分烊化，再加入鸡子黄3枚，搅拌均匀即得中药组合物。
上述的中药组合物可用于制备清热除燥、养血止利的药物。
实施例4
本实施例提供一种中药组合物，所述中药组合物中包括鸡子黄2枚、阿胶25g、黄连15g、黄芩30g、芍药10g、人参5g、炙甘草20g。
本实施例还提供一种制备中药组合物的方法，其包括如下步骤：
S1、按比例取黄连、黄芩、芍药、人参、炙甘草加水720ml浸泡20min，得到混合物，其中，人参为切片处理后得到；
S2、煎煮S1中的混合物，先大火加热至沸腾，然后转小火，在115℃下继续煎煮90min；
S3、关火，过滤，除去药渣，得药汁560ml；
S4、将阿胶打成粉状加入上述药汁中充分烊化，再加入鸡子黄1枚，搅拌均匀即得中药组合物。
上述的中药组合物可用于制备清热除燥、养血止利的药物。
参见表1，本发明还提供实施例5-10的中药组合物，所述中药组合物可用于制备清热除燥、养血止利的药物。
表1所示的实施例均由实施例1-4所述的制备方法制备而得，
Figure PCTCN2018117738-appb-000001
表1实施例5-10提供的中药组合物
实验例
实验对象：患者共845例，其中男性患者467例，女性患者378例，年龄分布为9-60岁之间，所有患者火毒内盛所导致的热性痢疾甚至是血性痢疾，临床表现为身热无汗或少汗，口干渴，心中烦躁不安，或烦躁失眠，肌肤热燥而衄见里急下利，甚则痢下纯血，日数十行，蠃瘦如柴，腹中绞急，痛如刀刺。
治疗方式：服用本发明实施例1方案中的中药组合物药汁，分早中晚三次服用，每次服用150-350ml，温服七合，并进行临床疗效观察。
疗效判断标准：1)治愈，症状和体征完全消失；2)显效，治疗后大部分的症状和体征消失；3)无效，症状和体征没有得到缓解甚至有加重的趋势。
疗效统计：据统计，所有实验患者中，治愈597例，显效196例，无效52例，总有效率为93.8％。
如此，说明本方案中的中药组合物，在各个特定配伍的中药材组分间的相互配合、协同作用下，于治愈或缓解因温热之邪引起的相关病症方面，具有热除燥、养血止利的显著疗效，适合临床推广应用。
以上所述仅为本发明的实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书所作的等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。

Claims (10)

  1. 一种中药组合物，其特征在于，按重量份计，由以下配比的中药原料组合制得：鸡子黄1-3枚、阿胶5-60份、黄连15-75份、黄芩10-50份、芍药10-50份、人参5-45份、炙甘草15-45份。
  2. 如权利要求1所述的中药组合物，其特征在于，按重量份计，由以下中药原料组合制得：鸡子黄1-2枚、阿胶15-25份、黄连20-42份、黄芩14-28份、芍药15-32份、人参8-21份、炙甘草19-25份。
  3. 如权利要求1所述的中药组合物，其特征在于，按重量份计，由以下中药原料组合制得：鸡子黄2-3枚、阿胶35-59份、黄连53-73份、黄芩30-47份、芍药35-48份、人参31-40份、炙甘草29-43份。
  4. 如权利要求1所述的中药组合物，其特征在于，按重量份计，由以下中药原料组合制得：鸡子黄2枚、阿胶45份、黄连60份、黄芩30份、芍药30份、人参30份、炙甘草30份。
  5. 一种如权利要求1-4任一项所述的中药组合物的制备方法，其特征在于，包括如下步骤：
    S1、按比例取黄连、黄芩、芍药、人参以及炙甘草加水浸泡，得到混合物；
    S2、煎煮S1中的混合物，
    S3、过滤，除去药渣，得药汁；
    S4、将阿胶加入药汁中烊化，再加入鸡子黄，搅拌均匀即得。
  6. 如权利要求5所述的制备方法，其特征在于：所述S1步骤中，中药原料与水的质量比为1：9-11，浸泡时间为20-40min。
  7. 如权利要求5所述的制备方法，其特征在于：所述S2步骤中，先加热至沸腾，然后在100-115℃下继续煎煮60-90min。
  8. 如权利要求5所述的制备方法，其特征在于：所述S3步骤中，最终所得药汁量为加入水的体积的1/5-3/5。
  9. 如权利要求5所述的制备方法，其特征在于：所述S4步骤中，阿胶为粉状。
  10. 一种如权利要求1-4任一项所述的中药组合物在制备清热除燥、养血止利的药物中的应用。
PCT/CN2018/117738 2018-11-27 2018-11-27 一种中药组合物及其制备方法以及应用 WO2020107226A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2018/117738 WO2020107226A1 (zh) 2018-11-27 2018-11-27 一种中药组合物及其制备方法以及应用
CN201880028278.6A CN111491647A (zh) 2018-11-27 2018-11-27 一种中药组合物及其制备方法以及应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/117738 WO2020107226A1 (zh) 2018-11-27 2018-11-27 一种中药组合物及其制备方法以及应用

Publications (1)

Publication Number Publication Date
WO2020107226A1 true WO2020107226A1 (zh) 2020-06-04

Family

ID=70853680

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/117738 WO2020107226A1 (zh) 2018-11-27 2018-11-27 一种中药组合物及其制备方法以及应用

Country Status (2)

Country Link
CN (1) CN111491647A (zh)
WO (1) WO2020107226A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109498655A (zh) * 2018-12-27 2019-03-22 东阿阿胶股份有限公司 一种鲜阿胶及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520673A (zh) * 2013-10-12 2014-01-22 谭钦文 治疗气血不足证型月经病的中药
CN106552030A (zh) * 2015-09-18 2017-04-05 于伟 一种清热补血的中药配方
CN108452038A (zh) * 2017-02-21 2018-08-28 王新军 一种清热补血全新中药方

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103230448A (zh) * 2013-04-19 2013-08-07 康美药业股份有限公司 一种黄连阿胶汤复方配方颗粒及其制备方法和检测方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520673A (zh) * 2013-10-12 2014-01-22 谭钦文 治疗气血不足证型月经病的中药
CN106552030A (zh) * 2015-09-18 2017-04-05 于伟 一种清热补血的中药配方
CN108452038A (zh) * 2017-02-21 2018-08-28 王新军 一种清热补血全新中药方

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YONG ZONGYOU: "Treatment of "postoperative" disease with classic prescription", no. 4, 30-04-1985, pages 30 - 31 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109498655A (zh) * 2018-12-27 2019-03-22 东阿阿胶股份有限公司 一种鲜阿胶及其制备方法
CN109498655B (zh) * 2018-12-27 2022-05-03 东阿阿胶股份有限公司 一种鲜阿胶及其制备方法

Also Published As

Publication number Publication date
CN111491647A (zh) 2020-08-04

Similar Documents

Publication Publication Date Title
CN105362937A (zh) 一种可有效治疗肺结核的中药组合物及其制备方法
CN104435831A (zh) 一种治疗美尼尔氏综合症的药物及制备方法
WO2020107226A1 (zh) 一种中药组合物及其制备方法以及应用
WO2020107224A1 (zh) 一种中药组合物及其制备方法及应用
CN113842443A (zh) 用于治疗鼻咽癌放疗后口干症的药物组合物
CN103330854A (zh) 一种治疗鼻出血的中药组合物
WO2020107207A1 (zh) 一种中药组合物及其制备方法及应用
CN105030592A (zh) 一种青盐杜仲牙膏及其制作方法
CN104547369A (zh) 一种治疗眼睑痉挛的内服药物及其制备方法
CN104606471A (zh) 一种治疗慢性胃炎的中药组合物
WO2020107227A1 (zh) 一种中药组合物及其制备方法以及应用
CN102327440A (zh) 治疗流注的中草药
CN103007170B (zh) 一种治疗复发性口腔溃疡的中药组合物
WO2020107225A1 (zh) 一种中药组合物及其制备方法以及应用
CN105663850A (zh) 一种治疗口腔溃疡的中药组合物
CN105617162A (zh) 一种治疗口疮的中药组合物
WO2020107219A1 (zh) 一种中药组合物及其制备方法及应用
WO2020107210A1 (zh) 一种治疗哮喘的中药组合物及其制备方法和制药用途
WO2020107229A1 (zh) 一种中药组合物及其制备方法以及应用
CN117959383A (zh) 一种治疗肺结核的中药配方及制备方法
CN105055840A (zh) 治疗心律失常的药剂及其制备方法
CN104984004A (zh) 一种治疗全身淋巴结肿大的内服药物及其制备方法
CN105288118A (zh) 主治尿毒症的中药组合物及制法
CN104288429A (zh) 一种治疗阿狄森氏综合征的药物及制备方法
CN105561229A (zh) 一种治疗月经推迟的药物

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18941329

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 09.09.2021)

122 Ep: pct application non-entry in european phase

Ref document number: 18941329

Country of ref document: EP

Kind code of ref document: A1