WO2020107207A1 - 一种中药组合物及其制备方法及应用 - Google Patents

一种中药组合物及其制备方法及应用 Download PDF

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WO2020107207A1
WO2020107207A1 PCT/CN2018/117655 CN2018117655W WO2020107207A1 WO 2020107207 A1 WO2020107207 A1 WO 2020107207A1 CN 2018117655 W CN2018117655 W CN 2018117655W WO 2020107207 A1 WO2020107207 A1 WO 2020107207A1
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chinese medicine
parts
traditional chinese
raw materials
medicine composition
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刘志杰
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深圳市得道健康管理有限公司
刘志杰
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Priority to PCT/CN2018/117655 priority Critical patent/WO2020107207A1/zh
Priority to CN201880028280.3A priority patent/CN111615394A/zh
Publication of WO2020107207A1 publication Critical patent/WO2020107207A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/906—Zingiberaceae (Ginger family)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • the invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, its preparation method and application.
  • the technical problem to be solved by the present invention is: how to provide a traditional Chinese medicine composition to treat the diseases mentioned in the background art.
  • the present invention discloses a traditional Chinese medicine composition, based on parts by weight, specifically prepared from the following combination of traditional Chinese medicine raw materials: Qianhu 30-150 parts, Scutellaria baicalensis 15-75 parts, ginger 10-50 10-50 copies of licorice.
  • the traditional Chinese medicine composition is prepared by combining the following traditional Chinese medicine raw materials: 120 parts of Qianhu, 45 parts of Scutellaria baicalensis, 30 parts of ginger, and 30 parts of roasted licorice.
  • the preparation method specifically includes the following steps:
  • water is added in an amount of 5-7 times the total weight of the traditional Chinese medicine raw materials, and soaked for 20-40 minutes.
  • step S4 the final volume of the medicinal juice is 9/28-12/28 corresponding to the volume of the added water.
  • the traditional Chinese medicine composition is used in the preparation of a medicine for reconciling yin and yang and removing anxiety.
  • the traditional Chinese medicine composition disclosed by the invention is prepared by combining the raw materials of traditional Chinese medicine of Qianhu, Scutellaria baicalensis, ginger and licorice root.
  • the traditional Chinese medicine compound formed from the above-mentioned traditional Chinese medicine raw materials through the synergistic effect of the various components, has the effect of reconciling yin and yang and removing troubles. It can be used to treat diarrhea, colds, headaches and upsets caused by cold evils invading the body , Nausea, abdominal pain, or pain in the cold, lower profits and other illnesses.
  • a traditional Chinese medicine composition is prepared by combining the following traditional Chinese medicine raw materials by weight: Qianhu 30g, Scutellaria baicalensis 75g, ginger 50g, and licorice root 50g.
  • During preparation first weigh 30g of Qianhu, 75g of Scutellaria baicalensis, 50g of ginger (slice) and 50g of licorice root, and add them to a Chinese medicine decoction tank. Then add 1025ml of water into the decoction pot to soak the traditional Chinese medicine raw materials for 20min. After the soaking is over, heat the decoction tank again. The heat can be heated to boiling in the decoction tank first, and then adjusted to a low fire, and the heating temperature can be kept at 100-115°C for 60 minutes. Turn off the heat, filter the solid-liquid mixture in the decoction tank through a fine mesh or gauze, separate and remove the medicine residue, and finally get 439ml of black medicine juice.
  • the raw material of the traditional Chinese medicine disperses wind and clears heat, lowers gas and reduces phlegm, and is used for wind-heat coughing, phlegm fullness, and sputum yellowing.
  • Radix Scutellariae can clear away heat and dampness, purify fire and detoxify, and stop bleeding. It can be used for damp temperature, hot summer, chest tightness and vomiting, hot and humid stomach, diarrhea, jaundice, lung heat and cough, high fever and thirst, blood heat and vomiting, carbuncle and sore.
  • Ginger can relieve cold, relieve vomiting in warmth, reduce phlegm and cough, and can be used for cold, cold, stomach vomiting, cold phlegm cough.
  • Roasted licorice tonicize the spleen and stomach, replenish qi, and can be used for weak spleen and stomach, fatigue, fatigue, heart palpitations, and pulse generation.
  • the traditional Chinese medicine composition can be used in the preparation of medicines for reconciling yin and yang and removing anxiety.
  • a Chinese medicine composition is prepared by combining the following Chinese medicine raw materials by weight: Qianhu 120g, Scutellaria baicalensis 45g, ginger 30g, and roasted licorice 30g.
  • During preparation first weigh 120g of Qianhu, 45g of Scutellaria baicalensis, 30g of ginger (sliced) and 30g of licorice root, and add each of the raw materials of traditional Chinese medicine to a Chinese medicine decoction pot. Then add 1400ml of water to soak the traditional Chinese medicine raw materials into the decoction pot, the total soaking time is 30min. After the soaking is completed, the decoction tank is heated again. Specifically, a large fire can be used to heat the boil tank to a boil, and then adjusted to a small fire, and the heating temperature is maintained at 100-115°C to continue decoction for 80 minutes. Turn off the heat, filter the solid-liquid mixture in the decoction tank with a fine mesh or gauze, separate and remove the medicine residue, and finally get 600ml of black medicine juice.
  • the traditional Chinese medicine composition can be used in the preparation of medicines for reconciling yin and yang and removing anxiety.
  • a traditional Chinese medicine composition is prepared by combining the following traditional Chinese medicine raw materials by weight: Qianhu 150g, Scutellaria baicalensis 15g, ginger 10g, and roasted licorice 10g.
  • the decoction tank When preparing, first weigh 150g of Qianhu, 15g of Scutellaria baicalensis, 10g of ginger (sliced) and 10g of licorice root, and add the weighed ingredients of each traditional Chinese medicine to a Chinese medicine decoction tank. Then add 1295ml water to soak the traditional Chinese medicine raw materials into the decoction pot, the total soaking time is 40min. After the traditional Chinese medicine raw materials are soaked, the decoction tank is heated. Specifically, it can be heated to a boil in the decoction tank, and then adjusted to a low fire, and the heating temperature is maintained at 100-115°C to continue decoction for 90 minutes. Turn off the heat, filter the solid-liquid mixture in the decoction tank with a fine mesh or gauze, separate and remove the drug residue, and finally obtain 416ml of black drug juice.
  • the traditional Chinese medicine composition can be used in the preparation of medicines for reconciling yin and yang and removing anxiety.
  • Subjects A total of 234 patients, including 128 male patients and 106 female patients, with age distribution ranging from 3 to 45 years old, all patients have symptoms of diarrhea caused by cold evil invasion of the human body, and the clinical manifestations are Cold, head pain, upset, nausea, abdominal pain or cold pain, lower profit, etc.
  • Treatment take the Chinese herbal medicine composition juice of the present invention, take it in three times a day, take 200ml each time, take it continuously for a week, and observe the clinical efficacy.
  • Criteria for curative effect 1) cured, symptoms and signs completely disappeared; 2) markedly effective, most symptoms and signs disappeared after treatment; 3) ineffective, symptoms and signs have not been relieved or even aggravated.
  • Efficacy statistics According to statistics, among all experimental patients, 107 were cured, 100 were markedly effective, and 33 were ineffective. The total effective rate was 88.5%.
  • the traditional Chinese medicine composition of the present invention under the mutual cooperation and synergistic effect of the Chinese herbal medicine components with specific compatibility of Qianhu, Scutellaria baicalensis, ginger and licorice root, can reconcile Yin and Yang and eliminate troubles It has a significant effect and can be used to treat Shaoyang's disease and impotence syndrome.
  • the symptoms are hot sweating or cold, head pain, upset, nausea, abdominal pain, or pain when cold, and it is very suitable. Clinical promotion and application.

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Abstract

一种中药组合物及其制备方法以及该中药组合物在制备调和阴阳、除烦解表的药物中的应用，该中药组合物由前胡30-150份、黄芩15-75份、生姜10-50份和炙甘草10-50份制得。

Description

一种中药组合物及其制备方法及应用 技术领域
本发明涉及中药领域，尤其是指一种中药组合物及其制备方法及应用。
背景技术
在人们日常生活中，常常容易因由寒邪侵袭人体而形成少阳病机证，阳痞证。具体症状为身热汗出或畏凉，头目痛，心烦，干呕，腹痛或遇寒则痛，下利等。针对上述常发病症，若每次都服用西药予以缓解或治疗，长期以往，极容易对人体形成一定的副作用或抗药性。因属于常发病症，若采用中药复方进行治疗，可相对更加安全有效，对人体的副作用伤害程度也可降到最低。然而，目前现有技术中也没有疗效较佳的中药复方。
发明内容
本发明所要解决的技术问题是：如何提供一种中药组合物来治疗背景技术所述的病症。
为了解决上述技术问题，本发明公开了一种中药组合物，按重量份计，具体由以下配比的中药原料组合制得：前胡30-150份、黄芩15-75份、生姜10-50份、炙甘草10-50份。
进一步的，按重量份计，由以下中药原料组合制得：前胡40-70份、黄芩55-70份、生姜35-45份、炙甘草35-45份。
进一步的，按重量份计，由以下中药原料组合制得：前胡80-110份、黄芩 35-50份、生姜25-35份、炙甘草25-35份。
进一步的，按重量份计，由以下中药原料组合制得：前胡120-140份、黄芩20-30份、生姜15-25份、炙甘草15-25份
进一步的，按重量份计，所述中药组合物由以下中药原料组合制得：前胡120份、黄芩45份、生姜30份、炙甘草30份。
此外，还公开了一种上述中药组合物的制备方法，该制备方法具体包括如下步骤：
S1、配料，按照所述配比称取前胡、黄芩、生姜和炙甘草中药原料；
S2、浸泡，加水浸泡称取好的上述中药原料；
S3、煎熬，加热煎熬经浸泡的上述中药原料；
S4、过滤，煎熬结束后进行过滤，除去药渣，得药汁。
进一步的，上述制备方法，所述S2浸泡步骤中，按照所述中药原料总重量5-7倍的量加入水，并浸泡20-40min。
进一步的，上述制备方法，所述S3煎熬步骤中，先加热至沸腾，然后在100-115℃下继续煎熬60-90min。
进一步的，上述制备方法，所述S4步骤中，最终所得药汁体积为加水量对应体积的9/28—12/28。
最后，还公开了上述中药组合物的一种应用，具体的，将所述中药组合物应用于调和阴阳、除烦解表的药物制备中。
本发明所公开的中药组合物由前胡、黄芩、生姜和炙甘草中药原料组合制得。由上述各个中药原料形成的中药复方，通过各个组分间的协同作用，具有调和阴阳、除烦解表的功效，可用于治疗由寒邪侵袭人体而导致的腹泻、畏凉、 头目痛、心烦、干呕、腹痛或遇寒则痛、下利等病症。
具体实施方式
为详细说明本发明的技术内容、所实现目的及效果，以下结合实施方式详予说明。
实施例1
一种中药组合物，按照重量计，由以下中药原料组合制得：前胡30g、黄芩75g、生姜50g、炙甘草50g。
制备时，先分别称取前胡30g、黄芩75g、生姜(切片)50g和炙甘草50g中药原料，并将其共同加入一中药煎熬罐中。再向煎熬罐中加入1025ml水浸泡中药原料，浸泡时间为20min。待浸泡结束后，再对煎熬罐进行加热，可先大火加热至煎熬罐内沸腾，然后再调整为小火，并保持加热温度在100-115℃下继续煎熬60min。关火，通过过滤细网或者纱布过滤煎熬罐中的固液混合物，分离除去药渣，最后得439ml黑色药汁。
该中药方剂中，中药原料前胡可散风清热，降气化痰，用于风热咳嗽痰多、痰热喘满、咯痰黄稠。黄芩可清热燥湿、泻火解毒、止血，可用于湿温、暑温胸闷呕恶、湿热痞满、泻痢、黄疸、肺热咳嗽、高热烦渴、血热吐衄、痈肿疮毒。生姜可解表散寒、温中止呕、化痰止咳，可用于风寒感冒、胃寒呕吐、寒痰咳嗽。炙甘草补脾和胃、益气复脉，可用于脾胃虚弱、倦怠乏力、心动悸、脉结代。
此外，在组方虽是用来治疗寒热错杂的中热多寒少疾病的组方，但是毕竟存在寒性的临床表现，所以不能用寒凉的芍药，以防加重腹泻下利的症状，所 以本组方采用寒凉之性较为平和的前胡。对应的症候表现较轻浅，津液受损不严重，不必加如大枣等来补津液，炙甘草完全能够满足临床需求，同时炙甘草在本组方中具有调和药性的功用。
所述中药组合物可应用于调和阴阳、除烦解表的药物制备中。
实施例2
一种中药组合物，按照重量计，由以下中药原料组合制得：前胡120g、黄芩45g、生姜30g、炙甘草30g。
制取时，先分别称取前胡120g、黄芩45g、生姜(切片)30g和炙甘草30g中药原料，并将各个中药原料共同加入一中药煎熬罐中。再向煎熬罐中加入1400ml水浸泡中药原料，总浸泡时间为30min。待浸泡结束后，再对煎熬罐进行加热，具体可先采用大火加热至煎熬罐内沸腾，然后再调整为小火，并保持加热温度在100-115℃下继续煎熬80min。关火，采用过滤细网或者纱布过滤煎熬罐中的固液混合物，分离除去药渣，最终得600ml黑色药汁。
所述中药组合物可应用于调和阴阳、除烦解表的药物制备中。
实施例3
一种中药组合物，按照重量计，由以下中药原料组合制得：前胡150g、黄芩15g、生姜10g、炙甘草10g。
制取时，可先分别称取前胡150g、黄芩15g、生姜(切片)10g和炙甘草10g中药原料，并将称取好的各个中药原料共同加入一中药煎熬罐中。再向煎熬罐中加入1295ml水浸泡中药原料，总浸泡时间为40min。待中药原料浸泡好后，再对煎熬罐进行加热，具体可先大火加热至煎熬罐内沸腾，然后再调整为小火，并保持加热温度在100-115℃下继续煎熬90min。关火，利用过滤细网或者过滤 纱布过滤煎熬罐的中固液混合物，分离除去其中的药渣，最终得到416ml的黑色药汁。
所述中药组合物可应用于调和阴阳、除烦解表的药物制备中。
实施例4-11
实施例4-11中组合物其具体组成如表1所示，而对应的制备方法则与实施例2相同。
表1
Figure PCTCN2018117655-appb-000001
实验例
实验对象：患者共234例，其中男性患者128例，女性患者106例，年龄分布为3—45岁之间，所有患者皆有因寒邪侵袭人体而导致的腹泻的症状，且 还临床表现为畏凉、头目痛、心烦、干呕、腹痛或遇寒则痛、下利等。
治疗方式：服用本发明中的中药组合物药汁，每日分三次服用，每次服用200ml，连续服用一周，并进行临床疗效观察。
疗效判断标准：1)治愈，症状和体征完全消失；2)显效，治疗后大部分的症状和体征消失；3)无效，症状和体征没有得到缓解甚至有加重的趋势。
疗效统计：据统计，所有实验患者中，治愈107例，显效100例，无效33例，总有效率为88.5％。
根据上述实验例可知：本发明中的中药组合物，在前胡、黄芩、生姜和炙甘草各个特定配伍的中药材组分间的相互配合、协同作用下，在调和阴阳，除烦解表方面具有显著的功效，可主治少阳病机证，阳痞证，且症见为身热汗出或畏凉、头目痛、心烦、干呕、腹痛或遇寒则痛、下利等，非常适合临床推广应用。
以上所述仅为本发明的实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书所作的等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。

Claims (10)

  1. 一种中药组合物，其特征在于，按重量份计，由以下配比的中药原料组合制得：前胡30-150份、黄芩15-75份、生姜10-50份、炙甘草10-50份。
  2. 如权利要求1所述的中药组合物，其特征在于，按重量份计，由以下中药原料组合制得：前胡40-70份、黄芩55-70份、生姜35-45份、炙甘草35-45份。
  3. 如权利要求1所述的中药组合物，其特征在于，按重量份计，由以下中药原料组合制得：前胡80-110份、黄芩35-50份、生姜25-35份、炙甘草25-35份。
  4. 如权利要求1所述的中药组合物，其特征在于，按重量份计，由以下中药原料组合制得：前胡120-140份、黄芩20-30份、生姜15-25份、炙甘草15-25份。
  5. 如权利要求1所述的中药组合物，其特征在于，按重量份计，由以下中药原料组合制得：前胡120份、黄芩45份、生姜30份、炙甘草30份。
  6. 一种如权利要求1-5任一项所述中药组合物的制备方法，其特征在于，包括如下步骤：
    S1、配料，按照所述配比称取前胡、黄芩、生姜和炙甘草中药原料；
    S2、浸泡，加水浸泡称取好的上述中药原料；
    S3、煎熬，加热煎熬经浸泡的上述中药原料；
    S4、过滤，煎熬结束后进行过滤，除去药渣，得药汁。
  7. 如权利要求6所述的制备方法，其特征在于：所述S2浸泡步骤中，按照所述中药原料总重量5-7倍的量加入水，并浸泡20-40min。
  8. 如权利要求6所述的制备方法，其特征在于：所述S3煎熬步骤中，先 加热至沸腾，然后在100-115℃下继续煎熬60-90min。
  9. 如权利要求6所述的制备方法，其特征在于：所述S4步骤中，最终所得药汁体积为加水量对应体积的9/28—12/28。
  10. 如权利要求1-5任一项所述中药组合物的一种应用，其特征在于：将所述中药组合物应用于调和阴阳、除烦解表的药物制备中。
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