WO2020107224A1 - 一种中药组合物及其制备方法及应用 - Google Patents

一种中药组合物及其制备方法及应用 Download PDF

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WO2020107224A1
WO2020107224A1 PCT/CN2018/117735 CN2018117735W WO2020107224A1 WO 2020107224 A1 WO2020107224 A1 WO 2020107224A1 CN 2018117735 W CN2018117735 W CN 2018117735W WO 2020107224 A1 WO2020107224 A1 WO 2020107224A1
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chinese medicine
traditional chinese
parts
medicine composition
cold
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PCT/CN2018/117735
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English (en)
French (fr)
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刘志杰
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深圳市得道健康管理有限公司
刘志杰
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Priority to PCT/CN2018/117735 priority Critical patent/WO2020107224A1/zh
Priority to CN201880028286.0A priority patent/CN111491653A/zh
Publication of WO2020107224A1 publication Critical patent/WO2020107224A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Definitions

  • the invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, its preparation method and application.
  • the human body will cause severe joint and muscle pain due to cold evil attack on the body, and even inconvenience of movement.
  • the clinical manifestations are often cold and chills, cold or heavy pain in the limbs, cold and severe pain in the waist and legs, body or muscle movement, timidity and scariness , Depressed expression, weak voice or accompanied by coughing, dizziness, palpitations, unfavorable urination, multiple tongues, pale tooth marks, slippery water, etc.
  • there is no traditional Chinese medicine composition with significant curative effect against the above-mentioned diseases in the existing traditional Chinese medicine compound.
  • the technical problem to be solved by the present invention is: the above-mentioned various diseases caused by the human body invading the body due to cold evil.
  • the present invention discloses a traditional Chinese medicine composition, based on parts by weight, including the following proportion of traditional Chinese medicine raw materials: Poria 15-75 parts, Guizhi 15-75 parts, Schisandra 10-50 parts , Atractylodes 15-45, dried ginger 15-75, aconite 5-20, roasted licorice 15-75.
  • the raw material of traditional Chinese medicine also includes 15-45 parts of Pinellia.
  • the traditional Chinese medicine raw materials also include 15-75 parts of Evodia.
  • the raw material of traditional Chinese medicine also includes 30-75 parts of Magnolia officinalis.
  • the raw material of traditional Chinese medicine also includes 15-45 parts of Asarum, which is used to target patients with cough.
  • the preparation method specifically includes the following steps:
  • water is added in an amount of 6-7 times the total weight of the traditional Chinese medicine raw materials, and soaked for 20-40 minutes.
  • the final volume of the medicinal juice is 9/40-12/40 corresponding to the volume of the added water.
  • the solution also discloses an application of the above-mentioned traditional Chinese medicine composition, specifically the application of the traditional Chinese medicine composition in the preparation of medicines for warming yanghua drink and reducing invigorating tonic.
  • the traditional Chinese medicine composition in the present invention warms the yanghua drink and lowers the tonic and replenishes the body.
  • Cold and chills caused by the invasion of cold evil, cold or heavy pain in the limbs, cold and severe pain in the waist and legs, body or muscle movement, poor sleep, sleepy, timid and frightened, depressed expression, weak voice, Or abdominal fullness, hiccups, nausea, loss of appetite, fullness of lumps in the chest, abdominal pain, lower profits, or accompanied by coughing, dizziness, palpitations, urinary discomfort, multiple tongue pale teeth marks, water slippery, etc. have significant symptoms Relief and treatment effect.
  • FIG. 1 is a flow chart of a method for preparing a traditional Chinese medicine composition of the present invention
  • a traditional Chinese medicine composition is prepared by combining the following traditional Chinese medicine raw materials by weight: Poria cocos 15g, Guizhi 15g, Schisandra chinensis 10g, Atractylodes macrocephala 45g, dried ginger 75g, aconite 20g and roasted licorice 75g.
  • Poria diarrhea dampens, strengthens the spleen and calms the heart, and is used for edema and urination, sputum drinking, dizziness, spleen deficiency, less food, loose stools, diarrhea, uneasiness, panic and insomnia.
  • Guizhi can sweat and dissipate muscles, warm the meridians, help yang and qi, and calm the air. It is used for colds, colds, abdominal pain, blood cold and amenorrhea, arthralgia, phlegm, edema, palpitations, dolphins, etc. Illness.
  • Schisandra converges, astringent, nourishes Qi, nourishes the kidneys, and is used for prolonged coughing, asthma, dreams, spermatorrhea, frequent enuresis, frequent urination, prolonged diarrhea, spontaneous sweating, night sweats, thirsty wounds, shortness of breath, deficiency of internal heat, palpitations, insomnia And other illnesses.
  • Atractylodes macrocephala for spleen and qi, dryness and dampness, antiperspirant, and fetal relief. It is used for spleen deficiency, lack of food, abdominal distension and diarrhea, phlegm and dizziness, edema, spontaneous sweating, fetal movement and other disorders.
  • Dried ginger can disperse cold in the middle of the temperature, return to the yang and clear the veins, remove dampness and reduce phlegm. It is used for symptoms such as abdominal pain, vomiting and diarrhea, cold limbs, phlegm and asthma. Fuzi returns to the sun to help recuperate, supplement the fire to help the yang, chase wind and dampness, and is used for dying yang collapse, cold limbs, impotence, palace cold, cold abdominal pain, vomiting and diarrhea due to cold, yin and cold edema, external sensation due to yang, cold Dampness and other diseases.
  • Zhigancao Yiqi nourishing blood, nourishing yin and reinvigorating the pulse can be used to treat deficiency of qi and weak blood, deficiency of qi, lack of qi, palpitations, palpitation, insomnia, dry stools, pale red tongue and less fur, pulse generation; and fatigue and impotence , Long coughing, salivation, thirst and thirst, blood in the sputum, palpitations, upset, lack of gas, insomnia, spontaneous sweating, sweating, pulse count and other diseases.
  • the above components are prepared by decoction under a specific ratio, and the medicinal effects of each component are coordinated with each other and have a synergistic effect.
  • the composition of the present invention can be mainly used for the treatment of cold and stagnation syndrome in the middle and late stages.
  • peony belongs to cold and cold products, and it is easy to increase the condition of severe patients with cold and cold.
  • Guizhi at the same time, Guizhi also has the function of warming the sun and reducing the vomiting, which can warm the water drink caused by the cold and evil intrusion; at the same time, the ginseng is cold and the big tonic fluid can aggravate the water and wetness of the patient’s water, so use temperature
  • the Schisandra chinensis can not only warm the yanghua drink but also alleviate the symptoms of fluid deficiency caused by the impediment of water distribution.
  • the traditional Chinese medicine composition is used in the preparation of medicines for warming yang drink and reducing invigorating tonic.
  • a traditional Chinese medicine composition is prepared by combining the following traditional Chinese medicine raw materials by weight: Poria cocos 60g, Guizhi 60g, Schisandra chinensis 40g, Atractylodes macrocephala 30g, dried ginger 60g, aconite 10g and roasted licorice 45g.
  • Poria cocos 60g, Guizhi 60g, Schisandra chinensis 40g, Atractylodes macrocephala 30g, dried ginger 60g, aconite 10g and roasted licorice 45g Chinese medicine raw materials are jointly added into a Chinese medicine decoction pot. Then add 2000ml of water into the decoction pot to soak the raw material of traditional Chinese medicine for 30min. Then heat the decoction pot again, and then heat it to boil in the decoction pot first, then adjust to a low fire, and keep the heating temperature at 100-115 °C to continue decoction for 100min. Turn off the heat, filter the solid-liquid mixture in the decoction tank, remove the drug residue, and get 600ml of juice.
  • the traditional Chinese medicine composition is applied to the preparation of medicines for warming Yang drink and reducing invigorating and replenishing jin.
  • Hogpus 50g a raw material of traditional Chinese medicine, can also be added.
  • a traditional Chinese medicine composition is prepared by combining the following traditional Chinese medicine raw materials by weight: Poria cocos 75g, Guizhi 75g, Schisandra chinensis 50g, Atractylodes macrocephala 15g, dried ginger 15g, aconite 5g and roasted licorice 15g.
  • the traditional Chinese medicine composition is applied to the preparation of medicines for warming Yang drink and reducing invigorating and replenishing jin.
  • Subjects A total of 139 patients, including 29 males and 110 females, with an age distribution of 55-75 years old, all patients suffered severe joint and muscle pain caused by cold evil invasion of the body, and even inconvenience, clinical manifestations were cold Chills, cold or heavy pain in the limbs, cold and severe pain in the waist and legs, body or muscle movement, timidity, panic, depression, low voice or accompanied by coughing, dizziness, palpitations, urination, etc., multilingual Moss with pale tooth marks is slippery.
  • Treatment take the Chinese herbal medicine composition juice of the present invention, take it three times in the morning, middle and evening, taking 200ml each time for one week, and observe the clinical efficacy.
  • Criteria for curative effect 1) cured, symptoms and signs completely disappeared; 2) markedly effective, most symptoms and signs disappeared after treatment; 3) ineffective, symptoms and signs have not been relieved or even aggravated.
  • the Chinese medicine composition of the present invention has a significant effect in curing or alleviating the related diseases caused by the cold evil invading the body under the mutual cooperation and synergy of each specific compatible Chinese herbal medicine component, which is suitable for clinical Promotion and application.

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Abstract

一种中药组合物，是由以下配比的中药原料制得：茯苓15-75份、桂枝15-75份、五味子10-50份、白术15-45份、干姜15-75份、附子5-20份、炙甘草15-75份。该组合物具有温阳化饮，降逆补津的作用，对寒邪入侵导致的身凉畏寒，四肢厥冷或沉重疼痛，腰腿寒凉重痛等多种疾病有效。

Description

一种中药组合物及其制备方法及应用 技术领域
本发明涉及中药领域，尤其是指一种中药组合物及其制备方法及应用。
背景技术
人体由于寒邪侵袭机体会导致剧烈关节肌肉疼痛，甚至行动不便，临床常表现为身凉畏寒，四肢厥冷或沉重疼痛，腰腿寒凉重痛，身体或肌肉瞤动，胆小易惊，神情抑郁，语声低弱或伴咳喘、眩晕、心悸、小便不利，多舌淡齿痕苔水滑等等。而现有的中药复方中，并没有针对上述病症拥有显著疗效的中药组合物。
发明内容
本发明所要解决的技术问题是：人体因寒邪侵袭身体带来的上述各种病症。
为了解决上述技术问题，本发明公开了一种中药组合物，按重量份计，包括由以下配比的中药原料制得：茯苓15-75份、桂枝15-75份、五味子10-50份、白术15-45份、干姜15-75份、附子5-20份、炙甘草15-75份。
进一步的，在上述方案基础上，所述中药原料还包括半夏15-45份。
进一步的，在上述方案基础上，所述中药原料还包括吴茱萸15-75份。
进一步的，在上述方案基础上，所述中药原料还包括厚朴30-75份。
进一步的，在上述方案基础上，所述中药原料还包括细辛15-45份，用于针对伴有咳嗽的患者。
此外，还公开了一种上述中药组合物的制备方法，该制备方法具体包括如下步骤：
S1、配料，按照所述配比分别称取各中药原料；
S2、浸泡，加水浸泡称取好的上述中药原料；
S3、煎熬，加热煎熬经浸泡的上述中药原料；
S4、过滤，煎熬结束后进行过滤，除去药渣，得药汁。
进一步的，所述S2浸泡步骤中，按照所述中药原料总重量6-7倍的量加入水，并浸泡20-40min。
进一步的，所述S3煎熬步骤中，先加热至沸腾，然后在100-115℃下继续煎熬90-120min。
进一步的，所述S4步骤中，最终所得药汁体积为加水量对应体积的9/40—12/40。
最后，本方案还公开了上述中药组合物的一种应用，具体为将所述中药组合物应用于温阳化饮，降逆补津的药物制备中。
本发明中的中药组合物温阳化饮，降逆补津。对寒邪入侵导致的身凉畏寒，四肢厥冷或沉重疼痛，腰腿寒凉重痛，身体或肌肉瞤动，眠差、欲寐，胆小易惊，神情抑郁，语声低弱，或腹满腹胀，呃逆欲呕，食欲不振，胸中痞结坚满，时腹痛、下利，或伴咳喘、眩晕、心悸、小便不利，多舌淡齿痕苔水滑等等病症具有显著的缓解和治疗效果。
附图说明
[根据细则91更正 28.12.2018]　
下面结合附图详述本发明的具体方案
[根据细则91更正 28.12.2018]　
图1为本发明一种中药组合物的制备方法流程图
具体实施方式
为详细说明本发明的技术内容、所实现目的及效果，以下结合实施方式详 予说明。
实施例1
一种中药组合物，按照重量计，由以下中药原料组合制得：茯苓15g、桂枝15g、五味子10g、白术45g、干姜75g、附子20g和炙甘草75g。
制备时，分别称取茯苓15g、桂枝15g、五味子10g、白术45g、干姜75g、附子20g和炙甘草75g中药原料，共同加入一中药煎熬罐中。再向煎熬罐中加入1530ml水浸泡中药原料，浸泡时间为20min。然后再对煎熬罐进行加热，可先大火加热至煎熬罐内沸腾，然后再调整为小火，并保持加热温度在100-115℃下继续煎熬90min。关火，过滤煎熬罐中固液混合物，除去药渣，得459ml药汁。
在中药方剂中，茯苓利水渗湿、健脾宁心，用于水肿尿少、痰饮眩悸、脾虚食少、便溏泄泻、心神不安、惊悸失眠等病症。桂枝可发汗解肌、温通经脉、助阳化气、平冲降气，用于风寒感冒、脘腹冷痛、血寒经闭、关节痹痛、痰饮、水肿、心悸、奔豚等病症。五味子收敛固涩、益气生津、补肾宁心，用于久嗽虚喘、梦遗滑精、遗尿尿频、久泻不止、自汗、盗汗、津伤口渴、短气脉虚、内热消渴、心悸失眠等病症。白术健脾益气、燥湿利水、止汗、安胎，用于脾虚食少、腹胀泄泻、痰饮眩悸、水肿、自汗、胎动不安等病症。干姜温中散寒、回阳通脉、燥湿消痰，用于脘腹冷痛、呕吐泄泻、肢冷脉微、痰饮喘咳等病症。附子回阳救逆、补火助阳、逐风寒湿邪，用于亡阳虚脱、肢冷脉微、阳萎、宫冷、心腹冷痛、虚寒吐泻、阴寒水肿、阳虚外感、寒湿痹痛等病症。炙甘草益气养血、滋阴复脉，可用于治气虚血弱、虚羸少气、心悸心慌、虚烦失眠、大便干结、舌质淡红少苔、脉结代；以及虚劳肺痿、久咳不止、涎唾甚多、咽燥而渴、痰中有血、心悸、心烦、少气、失眠、自汗盗汗、脉虚数等病症。上述 组分在特定的配比下，经煎煮制备，各组分的药效相互配合，具有协同增效的作用。
此外，本发明中组合物主要可用于治疗中后期的凉滞证，如芍药属于寒凉之品，容易以寒增寒增加重患者的病情，所以本组合物去芍药而加具有温经通脉作用的桂枝，同时桂枝还具有温阳化饮，降逆止呕的功用，能够温化寒邪内侵所导致的水饮；同时人参性凉且大补津液能够加重患者水饮水湿，所以用温性的五味子，既能温阳化饮又能缓解由于水液输布障碍而导致的津液亏虚的症状。
所述中药组合物应用于温阳化饮，降逆补津的药物制备中。
在上述方案基础上，针对伴有呕吐胸下结坚的患者，还可加入中药原料半夏15g。
在上述方案基础上，针对呕吐伴有头痛的患者，还可加入中药原料吴茱萸15g。
在上述方案基础上，针对伴有腹满的患者，还可加入中药原料厚朴30g。
在上述方案基础上，针对伴有咳嗽的患者，还可加入中药原料细辛15g。
实施例2
一种中药组合物，按照重量计，由以下中药原料组合制得：茯苓60g、桂枝60g、五味子40g、白术30g、干姜60g、附子10g和炙甘草45g。
制取时，茯苓60g、桂枝60g、五味子40g、白术30g、干姜60g、附子10g和炙甘草45g中药原料，共同加入一中药煎熬罐中。再向煎熬罐中加入2000ml水浸泡中药原料，浸泡时间为30min。然后再对煎熬罐进行加热，可先大火加热至煎熬罐内沸腾，然后再调整为小火，并保持加热温度在100-115℃下继续煎熬 100min。关火，过滤煎熬罐中固液混合物，除去药渣，得600ml药汁。
将所述中药组合物应用于温阳化饮，降逆补津的药物制备中。
在上述方案基础上，针对还同时伴有呕吐胸下结坚的患者，还可加入中药原料半夏30g。
在上述方案基础上，针对还同时呕吐并伴有头痛的患者，还可加入中药原料吴茱萸45g。
在上述方案基础上，针对还同时伴有腹满的患者，还可加入中药原料厚朴50g。
在上述方案基础上，针对还同时伴有咳嗽的患者，还可加入中药原料细辛30g。
实施例3
一种中药组合物，按照重量计，由以下中药原料组合制得：茯苓75g、桂枝75g、五味子50g、白术15g、干姜15g、附子5g和炙甘草15g。
制取时：分别称取茯苓75g、桂枝75g、五味子50g、白术15g、干姜15g、附子5g和炙甘草15g中药原料，共同加入一中药煎熬罐中。再向煎熬罐中加入1750ml水浸泡中药原料，浸泡时间为40min。然后再对煎熬罐进行加热，可先大火加热至煎熬罐内沸腾，然后再调整为小火，并保持加热温度在100-115℃下继续煎熬120min。关火，过滤煎熬罐中固液混合物，除去药渣，得394ml药汁。
将所述中药组合物应用于温阳化饮，降逆补津的药物制备中。
在上述方案基础上，针对伴有呕吐胸下结坚的患者，还可加入中药原料半夏45g。
在上述方案基础上，针对呕吐伴有头痛的患者，还可加入中药原料吴茱萸 75g。
在上述方案基础上，针对伴有腹满的患者，还可加入中药原料厚朴75g。
在上述方案基础上，针对伴有咳嗽的患者，还可加入中药原料细辛45g。
实施例4-13
实施例4-13中组合物其具体组成如表1所示，而对应的制备方法则与实施例2相同。
表1
Figure PCTCN2018117735-appb-000001
实验例
实验对象：患者共139例，其中男性患者29例，女性患者110例，年龄分布为55-75岁之间，所有患者由寒邪侵袭机体导致剧烈关节肌肉疼痛，甚至行 动不便，临床表现身凉畏寒，四肢厥冷或沉重疼痛，腰腿寒凉重痛，身体或肌肉瞤动，胆小易惊，神情抑郁，语声低弱或伴咳喘、眩晕、心悸、小便不利等，多舌淡齿痕苔水滑。
治疗方式：服用本发明中的中药组合物药汁，分早中晚三次服用，每次服用200ml，连续服用一周，并进行临床疗效观察。
疗效判断标准：1)治愈，症状和体征完全消失；2)显效，治疗后大部分的症状和体征消失；3)无效，症状和体征没有得到缓解甚至有加重的趋势。
疗效统计：据统计，所有实验患者中，治愈45例，显效78例，无效16例，总有效率为88.5％。
如此，说明本发明中的中药组合物在各个特定配伍的中药材组分间的相互配合、协同作用下，在治愈或缓解寒邪侵袭机体而导致的相关病症方面，具有显著的疗效，适合临床推广应用。
以上所述仅为本发明的实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书所作的等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。

Claims (10)

  1. 一种中药组合物，其特征在于，按重量份计，包括由以下配比的中药原料组合制得：茯苓15-75份、桂枝15-75份、五味子10-50份、白术15-45份、干姜15-75份、附子5-20份、炙甘草15-75份。
  2. 如权利要求1所述的中药组合物，其特征在于，所述中药原料组合还包括半夏15-45份。
  3. 如权利要求1所述的中药组合物，其特征在于，所述中药原料组合还包括吴茱萸15-75份。
  4. 如权利要求1所述的中药组合物，其特征在于，所述中药原料组合还包括厚朴30-75份。
  5. 如权利要求1所述的中药组合物，其特征在于，所述中药原料组合还包括细辛15-45份。
  6. 一种如权利要求1-5任一项所述中药组合物的制备方法，其特征在于，包括如下步骤：
    S1、配料，按照所述配比分别称取各中药原料；
    S2、浸泡，加水浸泡称取好的上述中药原料；
    S3、煎熬，加热煎熬经浸泡的上述中药原料；
    S4、过滤，煎熬结束后进行过滤，除去药渣，得药汁。
  7. 如权利要求6所述的制备方法，其特征在于：所述S2浸泡步骤中，按照所述中药原料总重量6-7倍的量加入水，并浸泡20-40min。
  8. 如权利要求6所述的制备方法，其特征在于：所述S3煎熬步骤中，先加热至沸腾，然后在100-115℃下继续煎熬90-120min。
  9. 如权利要求6所述的制备方法，其特征在于：所述S4步骤中，最终所 得药汁体积为加水量对应体积的9/40—12/40。
  10. 如权利要求1-5任一项所述中药组合物的一种应用，其特征在于：将所述中药组合物应用于温阳化饮，降逆补津的药物制备中。
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