CN105055840A - 治疗心律失常的药剂及其制备方法 - Google Patents
治疗心律失常的药剂及其制备方法 Download PDFInfo
- Publication number
- CN105055840A CN105055840A CN201510537925.4A CN201510537925A CN105055840A CN 105055840 A CN105055840 A CN 105055840A CN 201510537925 A CN201510537925 A CN 201510537925A CN 105055840 A CN105055840 A CN 105055840A
- Authority
- CN
- China
- Prior art keywords
- radix
- water
- parts
- take
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 91
- 229940079593 drugs Drugs 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims description 27
- 206010003119 Arrhythmia Diseases 0.000 title abstract description 13
- 206010007521 Cardiac arrhythmias Diseases 0.000 title abstract description 13
- 241001448530 Rohdea japonica Species 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 103
- 238000004140 cleaning Methods 0.000 claims description 52
- 239000012535 impurity Substances 0.000 claims description 39
- 241000628997 Flos Species 0.000 claims description 29
- 241001478744 Disporopsis pernyi Species 0.000 claims description 27
- 241000903946 Clematidis Species 0.000 claims description 26
- 241000921449 Rhodobryum roseum Species 0.000 claims description 26
- 239000011780 sodium chloride Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 18
- 239000002775 capsule Substances 0.000 claims description 17
- 238000009835 boiling Methods 0.000 claims description 16
- 241000209094 Oryza Species 0.000 claims description 13
- 235000007164 Oryza sativa Nutrition 0.000 claims description 13
- 238000001764 infiltration Methods 0.000 claims description 13
- 235000009566 rice Nutrition 0.000 claims description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound data:image/svg+xml;base64,PD94bWwgdmVyc2lvbj0nMS4wJyBlbmNvZGluZz0naXNvLTg4NTktMSc/Pgo8c3ZnIHZlcnNpb249JzEuMScgYmFzZVByb2ZpbGU9J2Z1bGwnCiAgICAgICAgICAgICAgeG1sbnM9J2h0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnJwogICAgICAgICAgICAgICAgICAgICAgeG1sbnM6cmRraXQ9J2h0dHA6Ly93d3cucmRraXQub3JnL3htbCcKICAgICAgICAgICAgICAgICAgICAgIHhtbG5zOnhsaW5rPSdodHRwOi8vd3d3LnczLm9yZy8xOTk5L3hsaW5rJwogICAgICAgICAgICAgICAgICB4bWw6c3BhY2U9J3ByZXNlcnZlJwp3aWR0aD0nMzAwcHgnIGhlaWdodD0nMzAwcHgnIHZpZXdCb3g9JzAgMCAzMDAgMzAwJz4KPCEtLSBFTkQgT0YgSEVBREVSIC0tPgo8cmVjdCBzdHlsZT0nb3BhY2l0eToxLjA7ZmlsbDojRkZGRkZGO3N0cm9rZTpub25lJyB3aWR0aD0nMzAwLjAnIGhlaWdodD0nMzAwLjAnIHg9JzAuMCcgeT0nMC4wJz4gPC9yZWN0Pgo8dGV4dCB4PSc2OS44JyB5PScxNzAuMCcgY2xhc3M9J2F0b20tMCcgc3R5bGU9J2ZvbnQtc2l6ZTo0MHB4O2ZvbnQtc3R5bGU6bm9ybWFsO2ZvbnQtd2VpZ2h0Om5vcm1hbDtmaWxsLW9wYWNpdHk6MTtzdHJva2U6bm9uZTtmb250LWZhbWlseTpzYW5zLXNlcmlmO3RleHQtYW5jaG9yOnN0YXJ0O2ZpbGw6IzNCNDE0MycgPk48L3RleHQ+Cjx0ZXh0IHg9Jzk3LjQnIHk9JzE3MC4wJyBjbGFzcz0nYXRvbS0wJyBzdHlsZT0nZm9udC1zaXplOjQwcHg7Zm9udC1zdHlsZTpub3JtYWw7Zm9udC13ZWlnaHQ6bm9ybWFsO2ZpbGwtb3BhY2l0eToxO3N0cm9rZTpub25lO2ZvbnQtZmFtaWx5OnNhbnMtc2VyaWY7dGV4dC1hbmNob3I6c3RhcnQ7ZmlsbDojM0I0MTQzJyA+YTwvdGV4dD4KPHRleHQgeD0nMTE4LjYnIHk9JzE1NC4wJyBjbGFzcz0nYXRvbS0wJyBzdHlsZT0nZm9udC1zaXplOjI2cHg7Zm9udC1zdHlsZTpub3JtYWw7Zm9udC13ZWlnaHQ6bm9ybWFsO2ZpbGwtb3BhY2l0eToxO3N0cm9rZTpub25lO2ZvbnQtZmFtaWx5OnNhbnMtc2VyaWY7dGV4dC1hbmNob3I6c3RhcnQ7ZmlsbDojM0I0MTQzJyA+KzwvdGV4dD4KPHRleHQgeD0nMTg2LjgnIHk9JzE3MC4wJyBjbGFzcz0nYXRvbS0xJyBzdHlsZT0nZm9udC1zaXplOjQwcHg7Zm9udC1zdHlsZTpub3JtYWw7Zm9udC13ZWlnaHQ6bm9ybWFsO2ZpbGwtb3BhY2l0eToxO3N0cm9rZTpub25lO2ZvbnQtZmFtaWx5OnNhbnMtc2VyaWY7dGV4dC1hbmNob3I6c3RhcnQ7ZmlsbDojNUJCNzcyJyA+QzwvdGV4dD4KPHRleHQgeD0nMjE0LjQnIHk9JzE3MC4wJyBjbGFzcz0nYXRvbS0xJyBzdHlsZT0nZm9udC1zaXplOjQwcHg7Zm9udC1zdHlsZTpub3JtYWw7Zm9udC13ZWlnaHQ6bm9ybWFsO2ZpbGwtb3BhY2l0eToxO3N0cm9rZTpub25lO2ZvbnQtZmFtaWx5OnNhbnMtc2VyaWY7dGV4dC1hbmNob3I6c3RhcnQ7ZmlsbDojNUJCNzcyJyA+bDwvdGV4dD4KPHRleHQgeD0nMjIyLjknIHk9JzE1NC4wJyBjbGFzcz0nYXRvbS0xJyBzdHlsZT0nZm9udC1zaXplOjI2cHg7Zm9udC1zdHlsZTpub3JtYWw7Zm9udC13ZWlnaHQ6bm9ybWFsO2ZpbGwtb3BhY2l0eToxO3N0cm9rZTpub25lO2ZvbnQtZmFtaWx5OnNhbnMtc2VyaWY7dGV4dC1hbmNob3I6c3RhcnQ7ZmlsbDojNUJCNzcyJyA+LTwvdGV4dD4KPC9zdmc+Cg== data:image/svg+xml;base64,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 [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 13
- 239000000052 vinegar Substances 0.000 claims description 13
- 238000005406 washing Methods 0.000 claims description 13
- 229940023488 Pill Drugs 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 235000012907 honey Nutrition 0.000 claims description 3
- 239000000546 pharmaceutic aid Substances 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 230000001737 promoting Effects 0.000 abstract description 12
- 210000000952 Spleen Anatomy 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 7
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 241000410338 Ajuga decumbens Species 0.000 abstract description 2
- 241000218158 Clematis Species 0.000 abstract description 2
- 240000002948 Ophiopogon intermedius Species 0.000 abstract description 2
- 241000906564 Actaea vaginata Species 0.000 abstract 1
- 240000004499 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 235000015655 Crocus sativus Nutrition 0.000 abstract 1
- 240000004229 Crocus sativus Species 0.000 abstract 1
- 241000445924 Epiphyllum <angiosperm> Species 0.000 abstract 1
- 241000921453 Rhodobryum Species 0.000 abstract 1
- 210000003813 Thumb Anatomy 0.000 abstract 1
- 241000331444 Vincetoxicum amplexicaule Species 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 21
- 210000004369 Blood Anatomy 0.000 description 19
- 208000002193 Pain Diseases 0.000 description 16
- 210000002216 Heart Anatomy 0.000 description 14
- 201000010099 disease Diseases 0.000 description 13
- 239000000796 flavoring agent Substances 0.000 description 13
- 235000019634 flavors Nutrition 0.000 description 13
- 210000004072 Lung Anatomy 0.000 description 11
- 206010011224 Cough Diseases 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 9
- 208000002173 Dizziness Diseases 0.000 description 7
- 210000004185 Liver Anatomy 0.000 description 7
- 231100000614 Poison Toxicity 0.000 description 7
- 210000000038 chest Anatomy 0.000 description 6
- 239000003440 toxic substance Substances 0.000 description 6
- 206010019233 Headache Diseases 0.000 description 5
- 206010022114 Injury Diseases 0.000 description 5
- 210000003734 Kidney Anatomy 0.000 description 5
- 210000000214 Mouth Anatomy 0.000 description 5
- 231100000869 headache Toxicity 0.000 description 5
- 230000001717 pathogenic Effects 0.000 description 5
- 230000001225 therapeutic Effects 0.000 description 5
- 206010017553 Furuncle Diseases 0.000 description 4
- 206010033557 Palpitations Diseases 0.000 description 4
- 210000002784 Stomach Anatomy 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000002522 swelling Effects 0.000 description 4
- 230000002936 tranquilizing Effects 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 206010003549 Asthenia Diseases 0.000 description 3
- 208000008035 Back Pain Diseases 0.000 description 3
- 208000001848 Dysentery Diseases 0.000 description 3
- 210000003026 Hypopharynx Anatomy 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 206010022437 Insomnia Diseases 0.000 description 3
- 208000008930 Low Back Pain Diseases 0.000 description 3
- 206010027327 Menstrual disease Diseases 0.000 description 3
- 206010027514 Metrorrhagia Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 230000000004 hemodynamic Effects 0.000 description 3
- 230000003908 liver function Effects 0.000 description 3
- 201000010874 syndrome Diseases 0.000 description 3
- 210000001015 Abdomen Anatomy 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 206010003658 Atrial fibrillation Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 241000486666 Ceratostigma plumbaginoides Species 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010018987 Haemorrhage Diseases 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 208000004396 Mastitis Diseases 0.000 description 2
- 210000003205 Muscles Anatomy 0.000 description 2
- 241000612118 Samolus valerandi Species 0.000 description 2
- 210000001013 Sinoatrial Node Anatomy 0.000 description 2
- 208000004078 Snake Bites Diseases 0.000 description 2
- 208000003734 Supraventricular Tachycardia Diseases 0.000 description 2
- 206010042772 Syncope Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000003213 activating Effects 0.000 description 2
- 201000000736 amenorrhea Diseases 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 230000000740 bleeding Effects 0.000 description 2
- 231100000319 bleeding Toxicity 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 201000003453 lung abscess Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 244000052769 pathogens Species 0.000 description 2
- 201000002930 sinoatrial node disease Diseases 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010001115 Adams-Stokes syndrome Diseases 0.000 description 1
- 241000208327 Apocynaceae Species 0.000 description 1
- 210000001367 Arteries Anatomy 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010003402 Arthropod sting Diseases 0.000 description 1
- 208000006673 Asthma Diseases 0.000 description 1
- 210000000481 Breast Anatomy 0.000 description 1
- 241001504282 Bryaceae Species 0.000 description 1
- 206010006582 Bundle branch block right Diseases 0.000 description 1
- 206010007554 Cardiac failure Diseases 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010013023 Diphtheria Diseases 0.000 description 1
- 241000668709 Dipterocarpus costatus Species 0.000 description 1
- 206010013781 Dry mouth Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000001780 Epistaxis Diseases 0.000 description 1
- 206010016286 Febrile disease Diseases 0.000 description 1
- 206010016766 Flatulence Diseases 0.000 description 1
- 208000003512 Furunculosis Diseases 0.000 description 1
- 206010019280 Heart failure Diseases 0.000 description 1
- 208000006750 Hematuria Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 206010025482 Malaise Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N Metoprolol Chemical compound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300.0' height='300.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 13.6,147.3 L 19.4,152.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 19.4,152.0 L 25.1,156.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 40.3,159.4 L 47.5,156.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 47.5,156.6 L 54.7,153.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 54.7,153.8 L 73.4,168.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 73.4,168.9 L 95.8,160.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 95.8,160.2 L 99.6,136.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 101.1,157.4 L 103.7,140.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-4' d='M 114.5,175.3 L 95.8,160.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 99.6,136.5 L 122.0,127.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 122.0,127.8 L 140.7,142.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 121.7,133.8 L 134.8,144.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 140.7,142.9 L 147.9,140.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 147.9,140.1 L 155.1,137.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-7 atom-17' d='M 140.7,142.9 L 136.9,166.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 170.3,140.1 L 176.0,144.7' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 176.0,144.7 L 181.8,149.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 181.8,149.3 L 204.2,140.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 204.2,140.7 L 205.2,133.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 205.2,133.9 L 206.3,127.1' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-10 atom-12' d='M 204.2,140.7 L 222.9,155.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 222.9,155.8 L 230.1,153.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 230.1,153.0 L 237.3,150.2' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 252.5,152.9 L 258.2,157.6' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 258.2,157.6 L 264.0,162.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 264.0,162.2 L 286.4,153.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-14 atom-16' d='M 264.0,162.2 L 260.2,185.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 136.9,166.6 L 114.5,175.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 131.8,163.5 L 116.2,169.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='29.4' y='167.2' class='atom-1' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='160.2' y='139.1' class='atom-8' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='205.0' y='121.8' class='atom-11' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='211.6' y='121.8' class='atom-11' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='242.4' y='151.9' class='atom-13' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='242.4' y='143.5' class='atom-13' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85.0' height='85.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 3.4,41.7 L 5.0,43.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 5.0,43.0 L 6.7,44.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 10.6,45.2 L 12.8,44.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 12.8,44.3 L 15.0,43.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 15.0,43.5 L 20.3,47.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 20.3,47.8 L 26.7,45.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 26.7,45.3 L 27.7,38.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 28.2,44.5 L 28.9,39.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-4' d='M 32.0,49.6 L 26.7,45.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 27.7,38.6 L 34.1,36.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 34.1,36.1 L 39.4,40.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 34.0,37.8 L 37.7,40.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 39.4,40.4 L 41.5,39.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 41.5,39.6 L 43.7,38.7' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-7 atom-17' d='M 39.4,40.4 L 38.3,47.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 47.7,39.5 L 49.3,40.9' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 49.3,40.9 L 51.0,42.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 51.0,42.2 L 57.3,39.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 57.3,39.8 L 57.6,38.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 57.6,38.0 L 57.9,36.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-10 atom-12' d='M 57.3,39.8 L 62.6,44.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 62.6,44.0 L 64.8,43.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 64.8,43.2 L 67.0,42.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 71.0,43.2 L 72.6,44.5' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 72.6,44.5 L 74.3,45.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 74.3,45.9 L 80.6,43.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-14 atom-16' d='M 74.3,45.9 L 73.2,52.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 38.3,47.1 L 32.0,49.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 36.9,46.2 L 32.4,47.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='6.9' y='48.9' class='atom-1' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='43.9' y='40.9' class='atom-8' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='56.6' y='36.0' class='atom-11' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='60.7' y='36.0' class='atom-11' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='67.2' y='44.6' class='atom-13' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='67.2' y='39.3' class='atom-13' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
</svg>
 COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 229960002237 Metoprolol Drugs 0.000 description 1
- 206010027599 Migraine Diseases 0.000 description 1
- 208000008085 Migraine Disorders Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 244000021150 Orbignya martiana Species 0.000 description 1
- 235000014643 Orbignya martiana Nutrition 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010034038 Parotitis Diseases 0.000 description 1
- 241000218641 Pinaceae Species 0.000 description 1
- 241000209454 Plumbaginaceae Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 208000000418 Premature Cardiac Complexe Diseases 0.000 description 1
- JWHAUXFOSRPERK-UHFFFAOYSA-N Propafenone Chemical compound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300.0' height='300.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 13.6,87.2 L 40.2,103.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 40.2,103.9 L 67.9,89.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 67.9,89.3 L 76.3,94.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 76.3,94.6 L 84.6,99.8' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 104.5,100.7 L 113.4,96.1' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 113.4,96.1 L 122.2,91.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 122.2,91.4 L 148.7,108.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 148.7,108.2 L 148.3,118.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 148.3,118.4 L 147.9,128.7' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-5 atom-7' d='M 148.7,108.2 L 176.5,93.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 176.5,93.6 L 184.8,98.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 184.8,98.8 L 193.2,104.1' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 213.1,105.0 L 221.9,100.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 221.9,100.3 L 230.8,95.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 230.8,95.7 L 232.0,64.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 237.2,91.2 L 238.1,69.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-14 atom-9' d='M 257.3,112.4 L 230.8,95.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 232.0,64.3 L 259.7,49.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 259.7,49.7 L 286.3,66.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 260.4,57.6 L 278.9,69.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 286.3,66.5 L 285.0,97.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 285.0,97.8 L 257.3,112.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 278.0,94.4 L 258.5,104.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 257.3,112.4 L 256.1,143.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 254.4,146.4 L 262.7,151.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 262.7,151.7 L 271.1,156.9' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 257.7,141.1 L 266.1,146.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 266.1,146.4 L 274.4,151.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-15 atom-17' d='M 256.1,143.8 L 228.3,158.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 228.3,158.4 L 227.1,189.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-19' d='M 227.1,189.7 L 199.3,204.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-19 atom-20' d='M 199.3,204.3 L 172.8,187.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-19 atom-20' d='M 192.0,207.1 L 173.4,195.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-25 atom-24 atom-19' d='M 198.1,235.7 L 199.3,204.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-20 atom-20 atom-21' d='M 172.8,187.6 L 145.1,202.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 145.1,202.2 L 143.8,233.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 151.1,207.1 L 150.3,229.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-22 atom-22 atom-23' d='M 143.8,233.5 L 170.4,250.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-23 atom-24' d='M 170.4,250.3 L 198.1,235.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-23 atom-24' d='M 171.6,242.5 L 191.0,232.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='90.7' y='112.3' class='atom-3' style='font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='90.7' y='123.4' class='atom-3' style='font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
<text x='143.7' y='145.8' class='atom-6' style='font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='152.4' y='145.8' class='atom-6' style='font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='199.2' y='116.6' class='atom-8' style='font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='278.8' y='166.8' class='atom-16' style='font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85.0' height='85.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 3.4,24.3 L 10.8,29.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 10.8,29.0 L 18.6,24.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 18.6,24.9 L 21.4,26.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 21.4,26.6 L 24.1,28.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 28.1,28.6 L 31.0,27.1' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 31.0,27.1 L 33.9,25.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 33.9,25.5 L 41.4,30.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 41.4,30.2 L 41.2,33.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 41.2,33.6 L 41.1,37.0' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-5 atom-7' d='M 41.4,30.2 L 49.2,26.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 49.2,26.1 L 51.9,27.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 51.9,27.8 L 54.6,29.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 58.6,29.8 L 61.5,28.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 61.5,28.2 L 64.4,26.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 64.4,26.7 L 64.8,17.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 66.2,25.5 L 66.5,19.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-24 atom-14 atom-9' d='M 71.9,31.4 L 64.4,26.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 64.8,17.9 L 72.6,13.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 72.6,13.8 L 80.0,18.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 72.8,16.0 L 78.0,19.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 80.0,18.5 L 79.7,27.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 79.7,27.3 L 71.9,31.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 77.7,26.4 L 72.2,29.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 71.9,31.4 L 71.6,40.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 71.1,41.0 L 73.8,42.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 73.8,42.7 L 76.5,44.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 72.0,39.5 L 74.7,41.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 74.7,41.2 L 77.5,42.9' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-15 atom-17' d='M 71.6,40.2 L 63.7,44.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-17 atom-18' d='M 63.7,44.4 L 63.4,53.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-18 atom-19' d='M 63.4,53.2 L 55.6,57.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-19 atom-20' d='M 55.6,57.3 L 48.1,52.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-19 atom-20' d='M 53.5,58.1 L 48.3,54.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-25 atom-24 atom-19' d='M 55.2,66.1 L 55.6,57.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-20 atom-20 atom-21' d='M 48.1,52.6 L 40.3,56.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 40.3,56.7 L 40.0,65.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-21 atom-21 atom-22' d='M 42.0,58.1 L 41.8,64.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-22 atom-22 atom-23' d='M 40.0,65.5 L 47.4,70.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-23 atom-24' d='M 47.4,70.2 L 55.2,66.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-23 atom-23 atom-24' d='M 47.8,68.0 L 53.3,65.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='24.3' y='32.6' class='atom-3' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='24.3' y='37.9' class='atom-3' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
<text x='39.2' y='42.1' class='atom-6' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='43.4' y='42.1' class='atom-6' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='54.8' y='33.8' class='atom-8' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='77.2' y='47.9' class='atom-16' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 JWHAUXFOSRPERK-UHFFFAOYSA-N 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000008128 Pulmonary Tuberculosis Diseases 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 206010062104 Renal mass Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241001417494 Sciaenidae Species 0.000 description 1
- 206010039911 Seizure Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 206010040639 Sick sinus syndrome Diseases 0.000 description 1
- 208000007888 Sinus Tachycardia Diseases 0.000 description 1
- 206010040741 Sinus bradycardia Diseases 0.000 description 1
- 206010042576 Suppressed lactation Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000008203 Tachypnea Diseases 0.000 description 1
- 206010043089 Tachypnoea Diseases 0.000 description 1
- 210000002435 Tendons Anatomy 0.000 description 1
- 231100000765 Toxin Toxicity 0.000 description 1
- 210000003932 Urinary Bladder Anatomy 0.000 description 1
- 210000002700 Urine Anatomy 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 210000003462 Veins Anatomy 0.000 description 1
- 231100000611 Venom Toxicity 0.000 description 1
- 210000001048 Venoms Anatomy 0.000 description 1
- 206010047302 Ventricular tachycardia Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 230000001746 atrial Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 235000021271 drinking Nutrition 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000004634 feeding behavior Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000005035 ginseng Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 201000010238 heart disease Diseases 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000037315 hyperhidrosis Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000001976 improved Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 201000005505 measles Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000025627 positive regulation of urine volume Effects 0.000 description 1
- 229960000203 propafenone Drugs 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000306 recurrent Effects 0.000 description 1
- 230000001105 regulatory Effects 0.000 description 1
- 230000003014 reinforcing Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000000268 renotropic Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000000391 smoking Effects 0.000 description 1
- 229920000638 styrene acrylonitrile Polymers 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 239000008852 wen-xin Substances 0.000 description 1
Abstract
本发明公开了治疗心律失常的药剂，主要由下列原料药制备而成，均为质量份：桂枝8-16；回心草10-13；石首鱼7-13；麦门冬11-14；白毛夏枯草9-15；雪里开7-14；黄脚鸡6-15；朴松实8-13；昙花10-14；合掌消9-13；羌活8-14；棕树心7-12；万年青10-15；紫金莲9-12；番红花7-15。本发明经多年临床实践总结而成，具有益气健脾、行气活血的功效，疗效显著。
Description
技术领域
[0001] 本发明涉及中医中药领域，特别是涉及治疗心律失常的药剂及其制备方法。
背景技术
[0002] 心律失常是由于窦房结激动异常或激动产生于窦房结以外，激动的传导缓慢、阻 滞或经异常通道传导，即心脏活动的起源和(或）传导障碍导致心脏搏动的频率和(或）节律 异常。心律失常的血流动力学改变的临床表现主要取决于心律失常的性质，类型，心功能及 对血流动力学影响的程度，如轻度的窦性心动过缓，窦性心律不齐，偶发的房性期前收缩， 一度房室传导阻滞等对血流动力学影响甚小，故无明显的临床表现，较严重的心律失常，如 病窦综合征，快速心房颤动，阵发性室上性心动过速，持续性室性心动过速等，可引起心悸， 胸闷，头晕，低血压，出汗，严重者可出现晕厥，阿-斯综合征，甚至猝死，由于心律失常的类 型不同，临床表现各异。中医认为，心律失常属中医心悸、怔忡、晕厥范畴，其病因主要为 "瘀"、"热"、"虚"三个方面，"瘀"为淤血内阻，心脉不畅；"热"为血分蕴热，与淤胶结难解； "虚"为气虚、阴虚，涉及心、脾、肝、肾四脏。
[0003] 公布号CN 104758553 A (申请号201510182945. 4)的中国专利文献公开了一种用 于治疗心律失常的中药，它是由以下重量配比的原料药材制备而成：薤白10份、人参10 份、五味子15份、生地25份、当归10份、桂枝10份、茯神12份、柏仁子15份、远志 10份。公布号CN 104173916 A (申请号201410361176. X)的中国专利文献公开了一种治 疗心律失常的中药制剂，其原料药材分别是：当归10份、赤芍10份、红花9份、琥珀8份、广 郁金9份、川考9份、失笑散8份、柴胡10份、枳壳12份。公布号CN 102284004 A(申请号 201110251914. 1)的中国专利文献公开了一种治疗心律失常的药剂，它是由下列原料药制 成：甘松、党参、桂枝、甘草、七叶一枝花、川考、石菖蒲、麦冬、五味子、密蒙花和黄精。
[0004] 中医药治疗此病的药物有不少，但大多存在缺陷，为改善患者的生活质量，提高治 疗效果，需要加强对此方面的研究，争取得到一种更安全有效的中药配方。
发明内容
[0005] 针对现有技术的问题，本发明的目的是提供一种效果显著、服用安全适用性广的 治疗心律失常的药剂及其制备方法。
[0006] 本发明的技术方案是： 治疗心律失常的药剂，主要由下列原料药制备而成，均为质量份：桂枝8-16 ;回心草 10-13 ;石首鱼7-13 ;麦门冬11-14 ;白毛夏枯草9-15 ;雪里开7-14 ;黄脚鸡6-15 ;朴松实 8-13 ;昙花10-14 ;合掌消9-13 ;羌活8-14 ;棕树心7-12 ;万年青10-15 ;紫金莲9-12 ;番红 花 7-15。
[0007] 优选方案为，桂枝1〇_14 ;回心草11_12 ;石首鱼9_11 ;麦门冬12_13 ;白毛夏枯草 10-14 ;雪里开9-12 ;黄脚鸡9-12 ;朴松实10-11 ;昙花11-13 ;合掌消10-12 ;羌活10-12 ; 棕树心9-10 ;万年青11-14 ;紫金莲10-11 ;番红花9-13。
[0008] 更加优选的是，桂枝12 ;回心草11. 5 ;石首鱼10 ;麦门冬12. 5 ;白毛夏枯草12 ; 雪里开10. 5 ;黄脚鸡10. 5 ;朴松实10. 5 ;昙花12 ;合掌消11 ;羌活11 ;棕树心9. 5 ;万年青 12. 5 ;紫金莲10. 5 ;番红花11。
[0009] 所述的治疗心律失常的药剂，将其制成药学上可接受的散剂，其制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量4-6倍的浓度20%盐水(优选的：加入盐 水量为石首鱼质量的5倍)，煮至熟透，取出，切成条状，置于油锅内，炸至表面呈黄色，取出， 沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮10-20分钟(优选的：煮 12-18分钟；更加优选的：煮15分钟)，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸25-35分钟（优选的：隔水蒸28-32分钟；更加优选的：隔水蒸30分钟），取出捣碎， 置于烤箱内，恒温烘干，取出； (5) 将步骤（1) (2) (3) (4)所制原料药粉碎过筛，即得散剂。
[0010] 所述的治疗心律失常的药剂散剂的制备方法，步骤（5)粉碎过100-200目筛(优选 的：粉碎过130-170目筛；更加优选的：粉碎过150目筛)。
[0011] 所述的治疗心律失常的药剂，将其制成药学上可接受的胶囊剂，其制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量4-6倍的浓度20%盐水(优选的：加入盐 水量为石首鱼质量的5倍)，煮至熟透，取出，切成条状，置于油锅内，炸至表面呈黄色，取出， 沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮10-20分钟(优选的：煮 12-18分钟；更加优选的：煮15分钟)，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸25-35分钟（优选的：隔水蒸28-32分钟；更加优选的：隔水蒸30分钟），取出捣碎， 置于烤箱内，恒温烘干，取出； (5) 将上述步骤所制原料药粉碎过60-140目筛(优选的：粉碎过80-120目筛；更加优 选的：粉碎过100目筛)，加入药学辅料，制成颗粒，装填入胶囊内，即得胶囊剂。
[0012] 所述的治疗心律失常的药剂胶囊剂的制备方法，步骤（5)每粒胶囊中所含药粉量 为0. 2-0. 4g (优选的：每粒胶囊内所含药粉量为0. 3g)。
[0013] 所述的治疗心律失常的药剂，将其制成药学上可接受的丸剂，其制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量4-6倍的浓度20%盐水(优选的：加入盐 水量为石首鱼质量的5倍)，煮至熟透，取出，切成条状，置于油锅内，炸至表面呈黄色，取出， 沥去油，放凉，粉碎； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮10-20分钟(优选的：煮 12-18分钟；更加优选的：煮15分钟)，取出，烘干粉碎； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸25-35分钟（优选的：隔水蒸28-32分钟；更加优选的：隔水蒸30分钟），取出捣碎， 与步骤（3)所制原料药一起加水煎煮20-30分钟（优选的：加水煎煮25分钟)，过滤后收集 滤液； (5) 喷雾干燥步骤（4)所得滤液，再与步骤（1) (2)所制药粉混合，加入炼蜜水泛制成 丸，即得丸剂。
[0014] 所述的治疗心律失常的药剂丸剂的制备方法，步骤（4)加水量为所煮原料药质量 的5-7倍(优选的：加水量为所煮原料药质量的6倍)。
[0015] 所述的治疗心律失常的药剂，将其制成药学上可接受的煎膏剂，其制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量4-6倍的浓度20%盐水(优选的：加入盐 水量为石首鱼质量的5倍)，煮至熟透，取出，切成条状，置于油锅内，炸至表面呈黄色，取出， 沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮10-20分钟(优选的：煮 12-18分钟；更加优选的：煮15分钟)，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸25-35分钟（优选的：隔水蒸28-32分钟；更加优选的：隔水蒸30分钟），取出捣碎， 与步骤（3)所制原料药一起加水煎煮15-25分钟(优选的：加水煎煮20分钟)，过滤后收集 滤液； (5) 将步骤（1) (2)所制原料药粉碎过80目筛，加入步骤（4)所得滤液内，加热浓缩至 清膏，即得煎膏剂。
[0016] 所述的治疗心律失常的药剂煎膏剂的制备方法，步骤（4)加水量为所煮原料药质 量的5-8倍(优选的：加水量为所煮原料药质量的6-7倍；更加优选的：加水量为所煮原料 药质量的6.5倍)。
[0017] 本发明提供的治疗心律失常的药剂配方科学，制备方法简单。除此之外，它的优良 之处还表现在： 1、 本发明所得产品，治疗效果好，治愈率高，可有效降低复发率； 2、 本配方经多年临床实践总结而成，具有益气健脾、行气活血的功效； 3、 本发明所选中药材，安全无副作用，可长期服用，能调节患者身体机能。
具体实施方式
[0018] 下面结合实施例和实验例详细说明本发明的技术方案，但保护范围不限于此。
[0019] 本发明所用主要中药原料的药理如下： 桂枝：性味与归经：辛、甘，温。归心、肺、膀胱经。功能与主治：发汗解肌，温通经脉，助 阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。
[0020] 回心草：基原：为真藓科植物红大叶藓的全草。性味：淡；微苦；平。归经：心经。 功能主治：养心安神；镇静。主心脏病；心慌；心悸怔忡；神经衰弱。
[0021] 石首鱼：基原：为石首鱼科动物大黄鱼或小黄鱼的肉。性味：甘，平。归经：脾；胃； 肝；肾经。功能主治：益气健脾；补肾；明目；止痢。主病后、产后体虚；乳汁不足；肾虚腰痛； 水肿；视物昏花；头痛；胃痛；泻痢。
[0022] 麦门冬：基原：为百合科植物麦冬或沿阶草的块根。性味：甘；微苦；寒。归经：肺； 胃；心经。功能主治：滋阴润肺；益胃生津；清心除烦。主肺燥干咳；肺痈；阴虚劳嗽；津伤 口渴；消渴；心烦失眠；咽喉疼痛；肠燥便秘；血热吐衄。
[0023] 白毛夏枯草：基原：为唇形科植物金疮小草的全草。性味：味苦；甘；性寒。归经： 归肺；肝经。功能主治：清热解毒；化痰止咳；凉血散血。主咽喉肿痛；肺热咳嗽；肺痈；目 赤肿痛；痢疾；痈肿疔疮；毒蛇咬伤；跌打损伤。
[0024] 雪里开：基原：为毛茛科植物单叶铁线莲的根或叶。性味：辛；苦；性凉。归经：心； 肺；胃经。功能主治：清热解毒；怯疲镇咳；彳丁气活血；止痛。主小儿尚热te风；咳嗽；咽喉 肿痛；头痛；胃痛；腹痛；跌打损伤；腮腺炎；疖毒疔疮；蛇伤。
[0025] 黄脚鸡：基原：为百合科植物深裂竹根七的根茎。性味：味甘；性平。功能主治：益 气健脾；养阴润肺；活血舒筋。主产后虚弱；小儿疳积；阴虚咳嗽；多汗；口干；跌打肿痛；风 湿疼痛；腰痛。
[0026] 朴松实：基原：为松科植物秦冷杉的球果。性味：甘；涩；微辛；性平。功能主治： 平肝熄风；调经活血；止带。主高血压痛；头痛；眩晕；心神不安；月经不调；崩漏；带下。
[0027] 昙花：基原：为仙人掌科植物昙花的花。性味：甘；性平。归经：肺；心经。功能主 治：清肺止咳；凉血止血；养心安神。主肺热咳嗽；肺痨；咯血；崩漏；心悸；失眠。
[0028] 合掌消：基原：为萝蘑科植物合掌消的根或全草。性味：味苦；辛；性平。归经：肺； 脾经。功能主治：清热解毒；祛风湿；活血消肿。主风湿痹痛；偏头痛；腰痛；月经不调；乳 痈；痈肿疔毒。
[0029] 羌活：性温，味辛、苦。具有散寒祛风、除湿止痛之功能。用于风寒感冒，头痛身疼。 本品辛温，气雄而散，发表力强，主散太阳经风邪及寒湿之邪，有散寒祛风、胜湿止痛之功。
[0030] 棕树心：基原：为棕榈科植物棕榈的心材。性味：味苦；涩；性平。归经：心；脾经。 功能主治：养心安神；收敛止血。主心悸；头昏；崩漏；脱肛；子宫脱垂。
[0031] 万年青：基原：为百合科万年青属植物万年青的根和根茎。药性：苦、微甘，寒，小 毒。归肺、心经。功用主治：清热解毒、强心利尿。主治咽喉肿痛，白喉，痄腮，疮疡肿毒，乳 痈，蛇虫咬伤，心力衰竭，水肿，臌胀，咯血，吐血。
[0032] 紫金莲：基原：为白花丹科植物岷江蓝雪花、蓝雪花的根。性味：辛；甘；性温；有 毒。归经：肝经。功能主治：行气活血止痛。主脘腹胁痛；跌打损伤；骨折。
[0033] 番红花：基原：为鸢尾科植物番红花花柱的上部及柱头。性味：甘；平。归经：心； 肝经。功能主治：活血祛瘀；散郁开结；凉血解毒。主痛经；经闭；月经不调；产后恶露不净； 腹中包块疼痛；跌扑损伤；忧郁痞闷；惊悸；温病发斑；麻疹。
[0034] 实施例1治疗心律失常的药剂，主要由下列原料药制备而成(每份10g):桂枝8份， 回心草10份，石首鱼7份，麦门冬11份，白毛夏枯草9份，雪里开7份，黄脚鸡6份，朴松实 8份，昙花10份，合掌消9份，羌活8份，棕树心7份，万年青10份，紫金莲9份，番红花7 份。上述治疗心律失常的药剂散剂的制备方法是： (1)取石首鱼洗净，放入锅内，加入石首鱼质量5倍的浓度20%盐水，煮至熟透，取出，切 成条状，置于油锅内，炸至表面呈黄色，取出，沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮15分钟，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸30分钟，取出捣碎，置于烤箱内，恒温烘干，取出； (5) 将步骤（1) (2) (3) (4)所制原料药粉碎过150目筛，即得散剂。
[0035] 实施例2治疗心律失常的药剂，主要由下列原料药制备而成(每份10g):桂枝16 份，回心草13份，石首鱼13份，麦门冬14份，白毛夏枯草15份，雪里开14份，黄脚鸡15份， 朴松实13份，昙花14份，合掌消13份，羌活14份，棕树心12份，万年青15份，紫金莲12 份，番红花15份。上述治疗心律失常的药剂胶囊剂的制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量5倍的浓度20%盐水，煮至熟透，取出，切 成条状，置于油锅内，炸至表面呈黄色，取出，沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮15分钟，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸30分钟，取出捣碎，置于烤箱内，恒温烘干，取出； (5) 将上述步骤所制原料药粉碎过100目筛，加入药学辅料，制成颗粒，装填入胶囊内， 每粒胶囊中所含药粉量为〇. 3g，即得胶囊剂。
[0036]典型病例：XXX，男性，36岁。主诉：间歇性心慌；病史：患者自三个月前因劳累过度 加饮酒过量，开始出现心慌症状，伴有轻微的胸闷气短，无头痛、昏厥等其他不适症，每次发 作时间为10-20分钟，自动缓解，反复发作，经医院心电图检查，确诊为心律失常。
[0037] 服用本实例所得胶囊剂，每次2-3粒，温开水冲服，一天两次，二十天为一个疗程， 患者服用十天后，心慌症状有所减轻，发作次数减少，继续服用两个疗程后，基本不发作，复 查显示心电图基本正常，停药随访半年，患者未复发。
[0038] 实施例3治疗心律失常的药剂，主要由下列原料药制备而成(每份10g):桂枝10 份，回心草11份，石首鱼9份，麦门冬12份，白毛夏枯草10份，雪里开9份，黄脚鸡9份，朴 松实10份，昙花11份，合掌消10份，羌活10份，棕树心9份，万年青11份，紫金莲10份， 番红花9份。上述治疗心律失常的药剂丸剂的制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量5倍的浓度20%盐水，煮至熟透，取出，切 成条状，置于油锅内，炸至表面呈黄色，取出，沥去油，放凉，粉碎； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮15分钟，取出，烘干粉 碎； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸30分钟，取出捣碎，与步骤（3)所制原料药一起加入所煮原料药质量6倍的水煎煮 25分钟，过滤后收集滤液； (5)喷雾干燥步骤（4)所得滤液，再与步骤（1) (2)所制药粉混合，加入炼蜜水泛制成 丸，即得丸剂。
[0039]典型病例：XXX，女性，45岁。病史：患者近一年内，反复性出现胸闷、心悸头晕乏力 等不适症，刚开始以为劳累过度所致，休息后可缓解，昨日无明显诱因病情再次发作，休息 后未能缓解，遂来医院就诊，经心电图显示，室上性心动过速，确诊为心律失常。
[0040] 经人推荐服用本实例所得丸剂，每次2-3丸，温开水冲服，一天两次，二十天为一 个疗程，患者服用一个疗程后，胸闷、心悸等不适症明显缓解，继续服用一个疗程后，诸症全 消，心电图正常，一年后随访，病情未再复发。
[0041] 实施例4治疗心律失常的药剂，主要由下列原料药制备而成(每份10g):桂枝14 份，回心草12份，石首鱼11份，麦门冬13份，白毛夏枯草14份，雪里开12份，黄脚鸡12份， 朴松实11份，昙花13份，合掌消12份，羌活12份，棕树心10份，万年青14份，紫金莲11 份，番红花13份。上述治疗心律失常的药剂煎膏剂的制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量5倍的浓度20%盐水，煮至熟透，取出，切 成条状，置于油锅内，炸至表面呈黄色，取出，沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮15分钟，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸30分钟，取出捣碎，与步骤（3)所制原料药一起加入所煮原料药质量6. 5倍的水煎 煮20分钟，过滤后收集滤液； (5) 将步骤（1) (2)所制原料药粉碎过80目筛，加入步骤（4)所得滤液内，加热浓缩至 清膏，即得煎膏剂。
[0042] 典型病例：XXX，男性，52岁。患者三个小时前，突然感到胸闷、心悸，气喘严重，并 伴有轻微的头晕、恶心，休息两个后，症状无明显改善，遂前往医院就诊，自述有吸烟饮酒 史，心电图显示窦性心动过速，完全性右束支传导阻滞，确诊为心律失常一阵发性心房颤 动。
[0043] 服用本实例所得煎膏剂，每次4_8g，温开水冲服，一天两次，二十天为一个疗程， 患者服用十天后，胸闷、心悸等症状缓解，头晕、恶心消除，继续服用一个疗程后，患者不适 症全部消除，心电图轻微异常，再服用一个疗程后，患者自感痊愈，停药半年内随访，正常生 活，病情未再发作。
[0044] 实施例5治疗心律失常的药剂，主要由下列原料药制备而成(每份10g):桂枝12 份，回心草11. 5份，石首鱼10份，麦门冬12. 5份，白毛夏枯草12份，雪里开10. 5份，黄脚鸡 10. 5份，朴松实10. 5份，昙花12份，合掌消11份，羌活11份，棕树心9. 5份，万年青12. 5 份，紫金莲10. 5份，番红花11份。上述治疗心律失常的药剂散剂的制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量5倍的浓度20%盐水，煮至熟透，取出，切 成条状，置于油锅内，炸至表面呈黄色，取出，沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮15分钟，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸30分钟，取出捣碎，置于烤箱内，恒温烘干，取出； (5) 将步骤（1) (2) (3) (4)所制原料药粉碎过150目筛，即得散剂。
[0045] 试验例1本发明所得治疗心律失常的药剂(实施例5)的临床应用： 选取人群：2013年4月-2014年12月，依据就诊病历，在四所医院筛选心律失常患者 281例，年龄19-65岁，平均年龄49. 2±2. 5岁，病程3个月-10年，其中男性患者162例，女 性患者119例。所有患者均有不同程度的心悸、胸闷、气促、失眠、乏力等症状，结合其体征 及心电图结果，符合中华医学会制定的心律失常诊断标准。
[0046] 试验前，将患者随机分为两组，实验组163例和对照组118例，两组在性别、年龄、 病程、病情等方面无显著差异。实验组服用本发明所得产品，一天两次，每次2-3g，温开水冲 月艮，二十天为一个疗程；对照组服用其他常规药物(心律平、倍他乐克、稳心颗粒等)。服药期 间对两组患者进行连续观察，记录症状改善、心电图、动态心电图改善情况。
[0047] 疗效判定标准：参照文献疗效标准，（1)治愈：心律失常消失90%以上，临床症状消 失或明显改善，心电图正常或明显改善；（2)有效：心律失常改善50%以上，临床症状大部分 消失或缓解，心电图改善；（3)无效：心律失常无减轻，症状及心电图改善不明显。总有效率 =治愈率+有效率 临床结果：经三个疗程的服药后，两组的治疗结果如表1所示：
由表1可知，实验组的治愈患者为106例，治愈率为65. 0%，有效患者为53例，总有效 率为97. 5%，而对照组被治愈的患者为60例，治愈率为50. 8%，有效的患者为39例，总有效 率83. 9%，明显低于实验组的治疗效果，说明本发明所得产品疗效显著，治愈率高。且服药期 间，实验组患者未出现不良反应，复查尿便常规，肝功肾功均正常，对照组患者有8例患者 出现恶心呕吐，复查血尿便常规，肝功肾功，有2例肝功异常，停药后不良反应均消失。
[0048] 本发明中所使用的中药，桂枝可温通经脉，回心草、昙花可养心安神，石首鱼、黄脚 鸡可益气健脾，麦门冬可滋阴润肺，白毛夏枯草、万年青可清热解毒，雪里开、紫金莲可行气 活血，朴松实可平肝熄风，合掌消可活血消肿，羌活可除湿止痛，棕树心可收敛止血，番红花 可散郁开结，多种药材协同作用，共奏益气健脾、行气活血之功效。
[0049] 应当指出的是，具体实施方式只是本发明比较有代表性的例子，显然本发明的技 术方案不限于上述实施例，还可以有很多变形。本领域的普通技术人员，以本发明所明确公 开的或根据文件的书面描述毫无异议的得到的，均应认为是本专利所要保护的范围。
Claims (10)
1. 治疗心律失常的药剂，其特征在于，主要由下列原料药制备而成，均为质量份：桂枝 8- 16 ;回心草10-13 ;石首鱼7-13 ;麦门冬11-14 ;白毛夏枯草9-15 ;雪里开7-14 ;黄脚鸡 6-15 ;朴松实8-13 ;昙花10-14 ;合掌消9-13 ;羌活8-14 ;棕树心7-12 ;万年青10-15 ;紫金 莲9-12 ;番红花7-15。
2. 如权利要求1所述的治疗心律失常的药剂，其特征在于，桂枝10-14 ;回心草11-12 ; 石首鱼9-11 ;麦门冬12-13 ;白毛夏枯草10-14 ;雪里开9-12 ;黄脚鸡9-12 ;朴松实10-11 ; 昙花11-13 ;合掌消10-12 ;羌活10-12 ;棕树心9-10 ;万年青11-14 ;紫金莲10-11 ;番红花 9- 13 (优选的是：桂枝12 ;回心草11. 5 ;石首鱼10 ;麦门冬12. 5 ;白毛夏枯草12 ;雪里开 10. 5 ;黄脚鸡10. 5 ;朴松实10. 5 ;昙花12 ;合掌消11 ;羌活11 ;棕树心9. 5 ;万年青12. 5 ;紫 金莲10. 5 ;番红花11)。
3. 如权利要求1-2任一所述的治疗心律失常的药剂，其特征在于，将其制成药学上可 接受的散剂，其制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量4-6倍的浓度20%盐水(优选的：加入盐 水量为石首鱼质量的5倍)，煮至熟透，取出，切成条状，置于油锅内，炸至表面呈黄色，取出， 沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮10-20分钟(优选的：煮 12-18分钟；更加优选的：煮15分钟)，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸25-35分钟（优选的：隔水蒸28-32分钟；更加优选的：隔水蒸30分钟），取出捣碎， 置于烤箱内，恒温烘干，取出； (5) 将步骤（1) (2) (3) (4)所制原料药粉碎过筛，即得散剂。
4. 如权利要求3所述的治疗心律失常的药剂散剂的制备方法，其特征在于，步骤（5)粉 碎过100-200目筛(优选的：粉碎过130-170目筛；更加优选的：粉碎过150目筛)。
5. 如权利要求1-2任一所述的治疗心律失常的药剂，其特征在于，将其制成药学上可 接受的胶囊剂，其制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量4-6倍的浓度20%盐水(优选的：加入盐 水量为石首鱼质量的5倍)，煮至熟透，取出，切成条状，置于油锅内，炸至表面呈黄色，取出， 沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮10-20分钟(优选的：煮 12-18分钟；更加优选的：煮15分钟)，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸25-35分钟（优选的：隔水蒸28-32分钟；更加优选的：隔水蒸30分钟），取出捣碎， 置于烤箱内，恒温烘干，取出； (5) 将上述步骤所制原料药粉碎过60-140目筛(优选的：粉碎过80-120目筛；更加优 选的：粉碎过100目筛)，加入药学辅料，制成颗粒，装填入胶囊内，即得胶囊剂。
6. 如权利要求5所述的治疗心律失常的药剂胶囊剂的制备方法，其特征在于，步骤（5) 每粒胶囊中所含药粉量为〇. 2-0. 4g(优选的：每粒胶囊内所含药粉量为0. 3g)。
7. 如权利要求1-2任一所述的治疗心律失常的药剂，其特征在于，将其制成药学上可 接受的丸剂，其制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量4-6倍的浓度20%盐水(优选的：加入盐 水量为石首鱼质量的5倍)，煮至熟透，取出，切成条状，置于油锅内，炸至表面呈黄色，取出， 沥去油，放凉，粉碎； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮10-20分钟(优选的：煮 12-18分钟；更加优选的：煮15分钟)，取出，烘干粉碎； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸25-35分钟（优选的：隔水蒸28-32分钟；更加优选的：隔水蒸30分钟），取出捣碎， 与步骤（3)所制原料药一起加水煎煮20-30分钟（优选的：加水煎煮25分钟)，过滤后收集 滤液； (5) 喷雾干燥步骤（4)所得滤液，再与步骤（1) (2)所制药粉混合，加入炼蜜水泛制成 丸，即得丸剂。
8. 如权利要求7所述的治疗心律失常的药剂丸剂的制备方法，其特征在于，步骤（4)加 水量为所煮原料药质量的5-7倍(优选的：加水量为所煮原料药质量的6倍)。
9. 如权利要求1-2任一所述的治疗心律失常的药剂，其特征在于，将其制成药学上可 接受的煎膏剂，其制备方法是： (1) 取石首鱼洗净，放入锅内，加入石首鱼质量4-6倍的浓度20%盐水(优选的：加入盐 水量为石首鱼质量的5倍)，煮至熟透，取出，切成条状，置于油锅内，炸至表面呈黄色，取出， 沥去油，放凉； (2) 取桂枝、昙花和番红花洗净除杂，加入姜块，置于醋水中煮10-20分钟(优选的：煮 12-18分钟；更加优选的：煮15分钟)，取出，烘干； (3) 将回心草、白毛夏枯草、雪里开和黄脚鸡除杂洗净，切丝，加入淘米水浸8分钟，取 出，置于炒锅内，文火翻炒，不断淋入冰糖水浸润，炒至表面变黄，取出，烘干； (4) 将麦门冬、朴松实、合掌消、羌活、棕树心、万年青和紫金莲洗净除杂，放入蒸锅内， 隔水蒸25-35分钟（优选的：隔水蒸28-32分钟；更加优选的：隔水蒸30分钟），取出捣碎， 与步骤（3)所制原料药一起加水煎煮15-25分钟(优选的：加水煎煮20分钟)，过滤后收集 滤液； (5) 将步骤（1) (2)所制原料药粉碎过80目筛，加入步骤（4)所得滤液内，加热浓缩至 清膏，即得煎膏剂。
10. 如权利要求9所述的治疗心律失常的药剂煎膏剂的制备方法，其特征在于，步骤 (4)加水量为所煮原料药质量的5-8倍(优选的：加水量为所煮原料药质量的6-7倍；更加 优选的：加水量为所煮原料药质量的6. 5倍)。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510537925.4A CN105055840A (zh) | 2015-08-28 | 2015-08-28 | 治疗心律失常的药剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510537925.4A CN105055840A (zh) | 2015-08-28 | 2015-08-28 | 治疗心律失常的药剂及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105055840A true CN105055840A (zh) | 2015-11-18 |
Family
ID=54485517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510537925.4A Pending CN105055840A (zh) | 2015-08-28 | 2015-08-28 | 治疗心律失常的药剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105055840A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434885A (zh) * | 2016-01-27 | 2016-03-30 | 刘兆英 | 一种治疗阴虚火旺型心律失常的中药及制备方法 |
-
2015
- 2015-08-28 CN CN201510537925.4A patent/CN105055840A/zh active Pending
Non-Patent Citations (2)
| Title |
|---|
| 曾庆琪: "《常见病内治小方》", 31 May 2002, 江苏科学技术出版社 * |
| 祝丹等: "心律失常的中医用药及组方规律探讨", 《陕西中医学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434885A (zh) * | 2016-01-27 | 2016-03-30 | 刘兆英 | 一种治疗阴虚火旺型心律失常的中药及制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106421649A (zh) | 一种治疗脑中风的中药组合物及其制备方法 | |
| CN103860773A (zh) | 用于治疗心肌缺血的中药组合物及其制备方法 | |
| CN105055840A (zh) | 治疗心律失常的药剂及其制备方法 | |
| CN105288118A (zh) | 主治尿毒症的中药组合物及制法 | |
| CN103550351B (zh) | 治疗偏头疼的中药组合物及其制备方法 | |
| CN105056071A (zh) | 防治心律不齐的中药方剂及制法 | |
| CN105168947A (zh) | 一种治疗肝阴不足证型胁痛的中药组合物 | |
| CN104888148A (zh) | 一种治疗慢性乙型肝炎的药物 | |
| CN105056072A (zh) | 一种治疗心律不齐的内服药 | |
| CN104873627A (zh) | 一种治疗荨麻疹的中药剂及制法 | |
| CN104435151A (zh) | 治疗高血压的中药制剂及制法 | |
| CN104435922A (zh) | 一种治疗动脉硬化的中药组合物 | |
| CN105616559A (zh) | 治疗急性细菌性痢疾的组合物 | |
| CN104435176B (zh) | 肝热上冲型高血压疏肝泄热药剂及制法 | |
| CN104887948A (zh) | 治疗心绞痛的中药方剂 | |
| CN105168647A (zh) | 治疗血栓闭塞性脉管炎的中药外洗剂及制法 | |
| CN105770545A (zh) | 一种治疗肺挫伤的中药制剂及其制备方法 | |
| CN105168929A (zh) | 主治脑癌的中药组合物及制法 | |
| CN105056010A (zh) | 一种医治心律失常的药剂及制法 | |
| CN105943915A (zh) | 一种治疗水饮凌心型心律失常的中药及制备方法 | |
| CN104940822A (zh) | 一种治疗心绞痛的中药剂及其制备方法 | |
| CN105055959A (zh) | 一种治疗血热妄行型疫黄病的中药 | |
| CN105596811A (zh) | 主治动脉粥样硬化的中药组合物及制法 | |
| CN105168555A (zh) | 用于医治脑癌的制剂及制法 | |
| CN105213837A (zh) | 一种医治肾阴虚型盗汗的制剂及制法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| C06 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C10 | Entry into substantive examination | ||
| CB02 | Change of applicant information |
Address after: 810000 Qinghai Province, Eastern District of Xining City Garden No. 21 North Street, building 3, Oriental Pearl 2-501 Applicant after: Huo Tongyan Address before: 250000 Shandong, Ji'nan, East Industrial and Commercial Road Flyover District No. 13 Applicant before: Huo Tongyan |
|
| CB02 | Change of applicant information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151118 |
|
| RJ01 | Rejection of invention patent application after publication |