WO2020062947A1 - 化学发光检测仪 - Google Patents

化学发光检测仪 Download PDF

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Publication number
WO2020062947A1
WO2020062947A1 PCT/CN2019/091425 CN2019091425W WO2020062947A1 WO 2020062947 A1 WO2020062947 A1 WO 2020062947A1 CN 2019091425 W CN2019091425 W CN 2019091425W WO 2020062947 A1 WO2020062947 A1 WO 2020062947A1
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WO
WIPO (PCT)
Prior art keywords
reaction cup
sample
reagent
cuvette
plate
Prior art date
Application number
PCT/CN2019/091425
Other languages
English (en)
French (fr)
Inventor
吴承云
张猛
房瑜
周伟伟
许德晨
景宏维
孙家振
张国秀
Original Assignee
基蛋生物科技股份有限公司
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Publication date
Application filed by 基蛋生物科技股份有限公司 filed Critical 基蛋生物科技股份有限公司
Publication of WO2020062947A1 publication Critical patent/WO2020062947A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403—Sample carriers with closing or sealing means
    • G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples
    • G01N2035/0422—Plate elements with several rows of samples carried on a linear conveyor
    • G01N2035/0424—Two or more linear conveyors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples
    • G01N2035/0425—Stacks, magazines or elevators for plates

Definitions

  • the present application relates to the field of biological sample analysis and detection equipment, and in particular, to a chemiluminescence detector.
  • Chemiluminescence detector is a combination of high-sensitivity chemiluminescence measurement technology and highly specific immune response. It is used for the detection and analysis of various antigens, antibodies, hormones and drugs. A new immunoassay technology developed after immunoassay.
  • the purpose of this application is to provide a chemiluminescence detector with a high degree of automation, which can reduce the risk of operators contacting medical waste.
  • a chemiluminescence detector includes: a sample injection device, the sample injection device is used to transport a sample test tube; a reaction cup replenishment and recovery device, the reaction cup replenishment and recovery device is used to transport the reaction cup and the recovery reaction cup; a reagent tray; a reagent tray It is used to place reagent kits or sample diluents; incubation plate components; incubation plate components are used to place the reaction cups delivered by the reaction cup replenishment and recovery device, and provide the required reaction temperature for the reaction of samples and reagents in the reaction cups; detection chamber; The detection chamber is used to detect the reaction solution reacted in the incubation tray; and a robotic arm system; the robotic arm system includes a reagent grasping arm device and a sample arm device; the reagent grasping arm device is provided with an electromagnetic gripper for grasping the reaction cup and a A suction needle assembly for sucking reagents or waste liquid; the reagent grasping arm device can be moved to the reaction cup replenishment and recovery device and
  • the cuvette lifting assembly includes a first driving mechanism and at least two cuvette holders for accommodating a cuvette box; the first driving mechanism is connected to the cuvette holder, It is used to drive the cuvette rack up and down; at least two cuvette feeding components; each cuvette feeding component includes a lid opening mechanism and a second driving mechanism; the second driving mechanism is connected to the lid opening mechanism and is used to drive the lid opening The mechanism moves to the bottom of the cuvette box to open the lid, and removes or returns the cuvette box after the opening to the cuvette holder; and a gripper assembly; the gripper assembly is configured to place the The cuvettes in the cuvette box are grasped and placed in the incubation plate; and the used cuvette clips are put back into the cuvette box after the lid is opened.
  • the cuvette tray and the cuvette tray are provided with a plurality of holes for placing the cuvette; the cuvette tray rotates intermittently according to a cycle; the cleaning component, the cleaning component includes a suction needle group And cleaning plate group; the cleaning plate group is set on the reaction cup plate, the liquid suction needle group can extend through the cleaning plate group and enter the reaction cup to suck waste liquid, and the cleaning plate group is provided with a cleaning tube group; and a magnetic adsorption component, magnetic
  • the adsorption assembly includes a magnetic adsorption part and a driving part for adsorbing magnetic beads; the driving part is drivingly connected to the magnetic adsorption part; wherein the driving part is configured to drive the magnetic force before the liquid suction needle group sucks the waste liquid in the reaction cup; The adsorption part moves in a direction close to the reaction cup to adsorb the magnetic beads on the side wall of the reaction cup.
  • the jaw assembly and the jaw assembly include two grippers; the electromagnetic drive mechanism, the electromagnetic drive mechanism and the jaw assembly are drivingly connected, and the two grippers for driving the jaw assembly approach each other Or stay away to clamp or release the cuvette; and a detection component, the detection component is connected to the electromagnetic drive mechanism, and the detection component detects whether the gripper catches the cuvette according to whether the electromagnetic drive mechanism is reset.
  • the chemiluminescence detector further includes a reaction cup shaker, and the reaction cup shaker is disposed below the reaction cup plate, and is used to shake and shake the reaction cup on the reaction cup plate;
  • the cup shaker includes: a frame; the frame includes a first fixed plate, a second fixed plate opposite to each other, and a guide post; the guide post is connected between the first fixed plate and the second fixed plate; a lifting component; a lifting component setting Between the first fixing plate and the second fixing plate; the lifting component can move between the first fixing plate and the second fixing plate along the guide column; and the shaker component; the shaker component is fixedly connected to the lifter component, and shakes evenly The component passes through the first fixing plate; the shaker assembly includes a reaction cup shaker seat and a rotation mechanism for placing the reaction cup; the reaction cup shaker seat is rotatably connected to the rotation mechanism.
  • the shape of the cuvette plate is substantially circular, and the reagent plate is disposed in the circular cuvette plate; the reagent plate is further provided with a reagent kit scanning component.
  • the chemiluminescence detector further includes a reaction cup lifting device, the reaction cup lifting device is disposed below the detection chamber, and the reaction cup lifting device is used for lifting the reaction cup in the incubation tray assembly. Raise to the testing room.
  • the reaction cup lifting device includes a lifting rack assembly and a lifting motor; the lifting rack assembly is drivingly connected to the lifting motor, and the lifting rack assembly can be connected to the reaction cup, and Driven by the lifting motor, the cuvette is lifted to the detection chamber.
  • the sample sampling device includes a rack feeding mechanism, a rack discharging mechanism, and a test tube rotating wheel mechanism;
  • the rack feeding mechanism is used to transport a sample rack with the sample test tubes to a close incubation tray assembly;
  • the mechanism is used to transport the sample rack away from the incubation tray assembly;
  • the test tube rotation wheel mechanism is used to drive each test tube sample on the sample rack to scan and scan the sample information.
  • the sample sampling device further includes a test tube pushing wheel mechanism.
  • the test tube pushing wheel mechanism is used for pressing the sample test tube on the sample rack, and cooperates with the test tube rotation wheel mechanism to scan the code.
  • a chemiluminescence detector provided by the present application includes a sample sampling device, a reaction cup replenishment and recovery device, a reagent tray, an incubation tray assembly, a detection chamber, and a robot arm system.
  • the sample injection device is used to transport a sample test tube.
  • the reaction cup replenishment and recovery device is used for conveying the reaction cup and recovering the reaction cup.
  • Reagent trays are used to hold kits or sample diluents.
  • the incubation tray assembly is used to place the reaction cup delivered by the reaction cup replenishment and recovery device, and provide the required reaction temperature for the reaction of the sample and reagent in the reaction cup.
  • the detection chamber is used to detect the reaction solution reacted in the incubation plate.
  • the robot arm system includes a reagent grasping arm device and a sample arm device; the reagent grasping arm device is provided with an electromagnetic gripper for grasping the reaction cup and an aspiration needle assembly for extracting reagents or waste liquid; the reagent grasping arm device can be moved to the reaction cup Resupply recovery device and incubation tray assembly; sample arm device can be moved to incubation tray assembly and sample injection device.
  • the reaction cup replenishment and recovery device can automatically open the lid of the reaction cup, and cooperate with the reagent grasping arm device to add the reaction cup to the incubation tray assembly.
  • the reagent plate provides reagents and is added to the reaction cup on the incubation plate assembly with the reagent grasping arm device.
  • the sample injection device transports the sample test tube, and cooperates with the sample arm device to add the sample to the reaction cup on the incubation tray assembly, so as to react with the reagents.
  • the incubation tray assembly performs a series of processing on the reaction cup and transfers it to the detection room for processing. Detection.
  • the entire process is highly automated, reducing the intensity of manual operations, and reducing the risk of operator exposure to medical waste.
  • FIG. 1-1 is a schematic structural diagram of a first perspective of chemiluminescence detection provided by an embodiment of the present application
  • FIG. 1-2 is a schematic structural view of a second viewing angle of a chemiluminescence detector provided in an embodiment of the present application;
  • Figure 2-1 is an exploded view of the incubation tray assembly
  • Figure 2-2 is a schematic structural diagram of a four-needle cleaning station for an incubation tray assembly
  • Figure 2-3 is a schematic structural diagram of a magnet pushing device of an incubation tray assembly
  • Figure 3-1 is a schematic perspective view of a reagent tray
  • Figure 3-2 is a schematic cross-sectional view of a reagent disc
  • Figure 4-1 is an exploded view of the reaction cup replenishment and recovery device
  • 4-2 is an exploded schematic view of a feeding component of the reaction cup replenishment and recovery device
  • FIG. 5 is a schematic structural diagram of a reagent grasping arm device
  • Figure 6-1 is a schematic structural diagram of a sample sampling device
  • Figure 6-2 is a schematic structural diagram of a rack feeding mechanism of a sample sampling device
  • FIG. 6-3 is a schematic structural diagram of a racking mechanism of a sample sampling device
  • 6-4 is a schematic structural diagram of a test tube rotating wheel mechanism of a sample sampling device
  • FIG. 7 is a schematic structural diagram of a test tube pushing wheel mechanism
  • FIG. 8 is a schematic structural diagram of a sample arm device
  • FIG. 9 is a schematic structural diagram of a reaction cup shaker
  • FIG. 10 is a schematic structural diagram of a reaction cup lifting device
  • FIG. 11 is an exploded schematic view of a detection chamber
  • FIG. 12 is a schematic diagram of a runner in a measurement room of a detection room
  • FIG. 13 is a schematic structural diagram of an electromagnetic gripper.
  • Icons 1-bottom frame; 101-cup box replacement port; 2-incubation tray assembly; 201-incubation tray support; 202-incubation tray insulation shell; 203-incubation tank; 204-incubation motor; 205-incubation drive gear; 206-reaction cup plate; 207-reaction cup; 208-bearing; 209-bearing cover; 210-incubation plate cover; 211-opening and closing door; 212-opening and closing door guide; 213-four-pin cleaning station; 214-magnet Propulsion device; 215-heating belt; 3-reagent tray; 301-reagent shaft; 302-rolling bearing; 303-sample reagent tray; 304-reagent box; 305-magnetic bead cup; 306-rotor top cover; 307-magnetic beads Rotating gear; 308-star gear; 309-cooling tank; 310-insulation shell; 311-Peltier; 312-water-cooled radiator; 313-reagent driven
  • orientations or positional relationships indicated by the terms “up” and “inner” are based on the orientations or positional relationships shown in the accompanying drawings, or the products used in this application are often used.
  • the orientation or position relationship of the placement is only for the convenience of describing the application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, structure and operation in a specific orientation, so it cannot be understood as limit.
  • This embodiment provides a chemiluminescence detector, which includes a bottom plate frame 1, an incubation tray assembly 2, a reagent tray 3, a reaction cup replenishment and recovery device 4, a robotic arm system, and sample injection.
  • the robot arm system includes a reagent gripper arm device 5 and a sample arm device 7.
  • the reaction cup replenishment and recovery device 4 can automatically open the lid of the reaction cup, and cooperate with the reagent grasping arm device 5 to add the reaction cup to the incubation tray assembly 2.
  • the reagent plate 3 provides reagents, and cooperates with the reagent grasping arm device 5 to add the reagents to the reaction cup on the incubation plate assembly 2.
  • the sample injection device 6 delivers a sample test tube, and cooperates with the sample arm device 7 to add a sample to the reaction cup on the incubation tray assembly 2 to react with the reagent.
  • the incubation tray assembly 2 incubates and shakes the reaction cup. Uniform and magnetic separation.
  • the cuvette lifting device 9 transfers a series of processed cuvettes on the incubation tray assembly 2 to the detection chamber 10 for detection. The entire process is highly automated, reducing the intensity of manual operations, and reducing the risk of operator exposure to medical waste.
  • the bottom frame 1 serves as the base of the entire chemiluminescence detector, an incubation tray assembly 2, a reagent tray 3, a reaction cup replenishment recovery device 4, a reagent grasping arm device 5, a sample feed
  • the sample device 6, the sample arm device 7, the cuvette shaker device 8, the cuvette lifting device 9, and the detection chamber 10 are all mounted on the bottom frame 1.
  • the incubation tray assembly 2 includes a reaction cup tray 206, a cleaning assembly, and a magnetic adsorption assembly.
  • a four-needle cleaning station 213 is selected as the cleaning component.
  • the magnetic attraction component selects the magnet propulsion device 214.
  • the incubation disk assembly 2 further includes an incubation disk support 201, an incubation disk insulation case 202, an incubation tank 203, an incubation motor 204, an incubation driving gear 205, a reaction cup 207, a bearing 208, a bearing cover 209, and an incubation disk cover 210.
  • the incubation tank 203 of the incubation tray assembly 2 is connected to a plurality of incubation tray struts 201 by screws and fixed on the bottom plate.
  • An incubation tray insulation shell 202 is arranged on the outside of the tray, and heat loss is reduced by thermal insulation cotton for thermal insulation.
  • the incubation motor 204 is installed on the incubation tank 203, and the incubation driving gear 205 is connected to the motor shaft.
  • the inner ring of the bearing 208 is fixed to the incubation tank 203 by the bearing cover 209.
  • the outer ring carries the reaction cup plate 206, and the reaction cup plate 206 can A number of reaction cups are loaded and serve as gears to mesh with the incubation driving gear 205.
  • the incubation motor 204 drives the reaction cup disc 206 to rotate, thereby driving the reaction cups in the disc to the sample addition position and reagent addition position.
  • the incubation plate cover 210 is fixed to the top of the incubation tank 203 by screws.
  • the incubation plate cover 210 is equipped with an opening and closing door 211 through an opening and closing door guide 212.
  • the opening and closing door 211 serves as both a reagent addition position and a reaction cup. The adding position is pushed away by the reagent grasping arm device 5 and closed by a return spring.
  • the incubation plate cover 210 is also provided with a sample application position.
  • the heating belt 215 is sandwiched between the incubation shell 202 and the incubation tank 203, and is attached to the bottom of the incubation tank 203.
  • a magnet advancement device 214 is arranged inside the incubation tank 203.
  • the magnet advancement device 214 includes Magnetic adsorption part and driving part for adsorbing magnetic beads.
  • the driving part is a lead screw motor, and the magnetic adsorption part can be approached or separated from the reaction cup tray under the driving of the lead screw motor.
  • the lead screw motor provides power and is guided by dual guide rails to implement the loading and evacuation of the magnetic field.
  • the magnet propulsion device 214 there is a four-needle cleaning station 213 fixed to the top of the incubation tank 203.
  • the schematic diagram of its structure is shown in Figure 2-2.
  • the four-needle cleaning station 213 is powered by a screw motor and guided by a linear guide to achieve the up and down movement of the cleaning needle.
  • the peristaltic pump is connected to the cleaning needle to extract the cleaning waste liquid.
  • the plunger pump fills the cleaning fluid.
  • the four-needle cleaning station 213 and the magnet propulsion device 214 jointly implement the magnetic separation function of the instrument.
  • the four-needle cleaning station 213 is also provided with an acid joint for injecting the acid excitation solution into the reaction cup.
  • the reagent tray 3 includes: a reagent shaft 301, a rolling bearing 302, a sample reagent tray 303, a reagent box 304, a magnetic bead cup 305, a runner cover 306, and a magnetic bead rotation gear 307. , Stellar gear 308, cooling tank 309, insulation case 310, Peltier 311, water-cooled radiator 312, reagent driven gear 313, reagent motor 314, reagent driving gear 315, motor bracket 316, code scanning bracket 317, code scanner 318. Scanning code pad 319, side insulation cotton 320, reagent tray cover 322, cover opening sensor 323, movable cover 324, bottom insulation cotton 325, pillar 326, and reagent reset optocoupler and code disk.
  • the reagent tray 3 is arranged in the inner ring of the incubation tray assembly 2 and is fixed on the bottom frame 1 through a plurality of pillars 326.
  • the heat insulation shell 310 is affixed with side insulation cotton 320 and bottom insulation cotton 325 to prevent heat exchange.
  • the reagent plate cover plate 322 is fixed on the cooling groove 309, and the movable cover plate 324 is placed on the cooling groove.
  • the cover opening sensor 323 can detect whether the movable cover plate 324 is open.
  • the reagent tray 3 is further provided with a reagent kit scanning component.
  • a motor bracket 316 is arranged on the reagent tray cover 322, and a code scanner 318 is fixed on the reagent tray 322.
  • the code scanner 318 passes through the window of the code scanner pad 319 fixed on the reagent tray cover 322. Scan code.
  • a reagent suction port 321 is reserved on the reagent plate cover 322.
  • the internal structure of the reagent tray is: the reagent motor 314 is fixed to the cooling tank 309 via the motor support 316, the reagent driving gear 315 is installed on the main shaft of the reagent motor 314, and the reagent driven gear 313 drives the reagent shaft 301 to rotate.
  • the reagent shaft 301 is installed in the central hole of the cooling tank 309 through the rolling bearing 302, and the sample reagent tray 303 is fixed to the reagent shaft 301 by screws.
  • the reagent reagent tray 303 is arranged in the sample reagent tray 303, and a magnetic bead cup 305 is placed at the end of each reagent kit 304.
  • the magnetic bead cup 305 is supported by the rotary cover 306.
  • the rotary cover is connected to the magnetic bead rotating gear 307, and the magnetic beads rotate.
  • the gear 307 is installed in the shaft hole of the sample reagent disc 303, and meshes with the sun gear 308 fixed in the cooling tank 309 to form a planetary gear train.
  • the magnetic bead rotation gear 307 revolves around the sun gear 308, and also rotates to drive the support.
  • the top cover 306 of the runner of the magnetic bead cup 305 is rotated to achieve the purpose of mixing the reagents in the magnetic bead cup 305.
  • the Peltier method is adopted.
  • Peltier 311 is attached to the cooling tank 309 on the cold side, and the hot side is attached to the water-cooled radiator 312.
  • the water-cooled radiator 312 and The water-cooled row arranged on the bottom plate frame 1 dissipates heat for it.
  • the reaction cup replenishment and recovery device 4 includes a reaction cup lifting assembly 400 and at least two sets of reaction cup feeding assemblies 410.
  • the first driving mechanism is connected to the cuvette holder for driving the cuvette holder to rise and fall.
  • the cuvette lifting assembly includes a first driving mechanism and at least two cuvette holders 404 for accommodating the cuvette cassette 405.
  • the first driving mechanism is a lead screw linear motor 401.
  • the reaction cup lifting assembly further includes a guide shaft 402, a support shaft 403, a guide shaft pressure plate 406, a guide shaft connection block 407, a linear bearing 408, and a shaft retaining ring 409.
  • the reaction cup holder 404 includes a top cover 4041, a left side plate 4042, a lower baffle 4043, a lifting frame bottom plate 4044, an elastic sheet 4045, and a right side plate 4046.
  • the working process of the cuvette lifting assembly 400 is that the cuvette holders 404 are installed on both sides of the guide shaft connection block 407, and the lead screw linear motor 401 provides power to make the guide shaft connection block 407 and the cuvette holder 404 along the guide shaft 402. Move up and down to the cup box replacement port 101 of the bottom frame 1 and add the cuvette box 405 to the cuvette holder 404 along the replacement port by the operator.
  • the left and right plates 4042 and 4046 of the cuvette holder 404 The chute ensures the preliminary positioning of the cuvette box 405 in the cuvette holder 404, and the cuvette box is fixed in the cuvette holder 404 through the elastic sheet 4045.
  • the cuvette lifting assembly 400 lifts and lowers the cuvette holder 404 to a specified height.
  • the cuvette feeding assembly 410 opens the cuvette box 405, and the hook removes the plastic holder 4052 of the cuvette box 405 and the cuvette therein.
  • For the reagent grasping arm device 5 grasp the reaction cup.
  • the cuvette feeding assembly 410 includes a lid opening mechanism and a second driving mechanism; the second driving mechanism is connected to the lid opening mechanism and is used to drive the lid opening mechanism to move to the bottom of the cuvette box for lid opening , And remove the lid of the cuvette box or return it to the cuvette holder.
  • the second driving mechanism is a motor 411.
  • the lid opening mechanism includes a supporting plate 416 and a positioning pin 418. The lid is opened by the positioning pin 418.
  • the reaction cup feeding assembly 410 further includes a motor support base 412, a motor mounting plate 413, a rail pad 414, a linear guide 415, a photocoupler 417, a driven rack 419, and a driving gear 420.
  • the working process of the cuvette feeding assembly 410 is that the motor 411 provides power, and the driving gear 420 and the driven rack 419 transmit power, which is guided by the linear guide 415, and the positioning pin 418 opens the lid of the cuvette box 405, and the hook is removed
  • the plastic holder 4052 and the cuvettes therein are conveyed to the bottom of the reagent grasping arm device 5 for grasping the cuvettes.
  • the used cuvettes are also recovered into the open-cylinder cuvette box 405 on the cuvette feeding assembly 410 via the electromagnetic gripper 513 of the reagent gripping arm device 5, and then returned to the cuvette holder in the cuvette lifting assembly 400.
  • the cuvette lifting assembly 400 is operated to the replacement port to replace the cuvette box 405.
  • the user only needs to add the cuvette box 405 from the replacement port, and then the lid can be automatically opened to transfer the cuvette to the reagent arm of the gripper, and added to the incubation plate by the electromagnetic gripper 513. After the cuvette is used up, the cuvette is picked up by the electromagnetic gripper 513 into the cuvette box 405 for recycling, which improves the degree of automation of the instrument and reduces the risk of the operator contacting medical waste.
  • the reagent gripping arm device 5 includes a gripping arm holder 501, a gripping arm base 502, a gripping arm x-direction motor 503, a gripping arm x-direction guide 504, a synchronization wheel 505, and a gripping arm x-direction timing belt.
  • the components of the reagent grasping arm device 5 are all mounted on the grasping arm base 502, and are mounted on the base frame 1 by the grasping arm bracket 501. It includes movements in two directions, x and z.
  • the x-direction movement is driven by the grasping arm x-direction motor 503.
  • the synchronous wheel 505 is mounted on the motor shaft, the x-direction synchronous belt and the driven wheel 509 mounted on the grasping arm base 502.
  • the transmission is guided by the gripping arm x-direction guide rail 504 mounted on the gripping arm base 502 to perform x-direction operation.
  • the electromagnetic gripper 513 is connected to the gripper z-direction guide 511 through the gripper seat 512 and the reagent needle 515 through the reagent needle mount 514.
  • the gripper z-direction guide rail 511 is mounted on the gripper z-direction base 507 and is mounted on the gripper z
  • the gripping arm z-direction motor 508 toward the base 507 is driven by a synchronization wheel 505 connected to the z-direction gripping arm z-direction motor 508, a driven wheel 509 mounted on the gripping arm z-direction base 507, and a gripping arm z-direction timing belt 510.
  • the transmission realizes the z-direction movement of the electromagnetic gripper 513 and the reagent needle 515, so as to realize the processes of gripping the reaction cup of the electromagnetic gripper 513 and the reagent suction of the reagent needle 515.
  • the reagent needle 515 is cleaned in a negative pressure flow by a reagent needle cleaning block 516 fixed to the grasping arm z toward the base 507.
  • a waste liquid needle assembly 517 is also installed on the grasping arm bracket 501 on one side, which is driven by a lead screw motor and driven by a linear guide to drive the waste liquid needle 518 down to suck the waste liquid in the reaction cup.
  • the electromagnetic gripper 513 includes a gripper assembly 5131, an electromagnetic drive mechanism 5132, a detection assembly 5133, and a gripper substrate 5134.
  • the jaw assembly 5131 includes two grippers.
  • the electromagnetic driving mechanism 5132 is drivingly connected to the jaw assembly 5131.
  • the two grippers used to drive the jaw assembly 5131 approach or move away from each other to clamp or release the reaction cup.
  • the detecting component 5133 is connected to the electromagnetic driving mechanism 5132, and the detecting component detects whether the gripper catches the reaction cup according to whether the electromagnetic driving mechanism 5132 is reset.
  • the electromagnetic drive mechanism has a small volume, a simple control system, and does not need to be equipped with an air source device. The structure is compact and the cost is low.
  • the setting of the detection component further guarantees the stability and reliability of the entire electromagnetic gripper device for grasping the reaction cup.
  • the sample injection device 6 includes a hexagonal pillar 601, a rack feeding mechanism 602, a driven wheel 603, an X-direction pushing frame guide 604, a pushing frame timing belt 605, a push rod connection block 606,
  • the entire injector is mounted on the bottom plate through the hexagonal pillar 601, and the injector tray 614 is mounted on the hexagonal pillar 601 for the user to place a sample rack.
  • the x-direction push frame mechanism is driven by a push frame motor 610.
  • the push frame motor 610 is equipped with a synchronous wheel 608, and is mounted on the base plate through the push frame motor bracket 609. It is driven by the push frame synchronous belt 605 and the driven wheel 603.
  • the X-direction pushing frame guide 604 is guided to perform the X-direction movement.
  • the push rod connecting block 606 is installed on the X-direction push frame guide rail 604, and a test tube push rod 611 is fixedly connected to the push rod connection block 606 to drive the sample rack and the test tube 612 to move in the x direction.
  • the racking mechanism 602 includes a racking guide rail base 6021, a racking guide rail 6022, a push-in slide base 6023, a push-in hook 6024, a rack-in motor support 6025, a rack-in motor 6026, and a rack-in synchronization With 6027.
  • the racking mechanism 602 is installed on the bottom plate through the racking guide base 6021, and the racking motor 6026 is connected to the racking guide base 6021 through the racking motor support 6025, and is synchronized by the synchronization wheel 608 and racking on the axis of the racking motor 6026.
  • the racking mechanism 607 includes a racking guide base 6071, a racking motor 6072, a racking lever 6073, a push pin 6074, a racking guide 6075, a racking carriage 6076, and a timing belt 6077.
  • the racking mechanism 607 is mounted on the bottom plate through the racking guide base 6071, and the racking motor 6072 is fixed to the racking rail base 6071, and is transmitted through the synchronous wheel 608, the timing belt 6077 and the driven wheel 603 installed on the shaft of the racking motor 6072.
  • the retraction slide 6076 Guided by the retraction guide 6075 installed on the retraction guide 6060, driving the retraction slide 6076 mounted on the retraction guide 6075, the retraction slide 6076 is equipped with a retraction lever 6073 through a push pin 6074 , Used to push the sample rack out.
  • the test tube rotating wheel mechanism 613 includes a rotating wheel motor 6131, a motor support 6132, a rotating wheel base 6133, a bearing holder 6134, a rubber wheel 6135, a rotating wheel timing belt 6136, and a rotating shaft 6137.
  • the test tube rotating wheel mechanism 613 installs the rotating wheel base 6133 on the bottom plate through the hexagonal pillar 601, and the rotating wheel motor 6131 is installed on the rotating wheel base 6133 through the motor support 6132.
  • the rotating shaft is driven by the synchronous wheel 608 and the rotating wheel timing belt 6136 to drive the rotating shaft. 6137 rotates, the rotating shaft 6137 is installed in the bearing seat 6134 through two bearings, and is fixed on the rotating wheel base 6133.
  • the other end of the rotating shaft 6137 is installed with a rubber wheel 6135, thereby driving the test tube to rotate.
  • the test tube pushing wheel mechanism 1700 includes a pushing wheel base 1701, a pushing wheel guide 1702, a pushing wheel screw motor 1703, a pushing wheel connection seat 1704, a pushing wheel link 1705, a cleaning pool seat 1706, and a rotary bearing 1707. , Code scanner 1708, sample needle cleaning pool 1709, push wheel bracket 1710, and code scanner bracket 1711.
  • the test tube pusher mechanism 1700 is mounted on the base plate via a pusher base 1701, on which a pusher guide rail 1702 is mounted, and a pusher bracket 1710 is mounted on the pusher guide rail 1702, which is driven by a pusher screw motor 1703 and is connected via a pusher connection 1704 transmits power to the push wheel bracket 1710, moves the push wheel bracket 1710 along the push wheel link 1705 on the push wheel guide 1702, and pushes the rotary bearing 1707 installed on the push wheel bracket 1710 to compact the test tube in the sample rack for supply
  • the test tube rotation wheel mechanism 613 rotates and scans the code.
  • the code scanner 1708 is mounted on the push wheel base 1701 through a code scanner bracket 1711.
  • the sample needle cleaning pool 1709 is mounted on the scanner holder 1711 through the cleaning pool base 1706 for the sample needle to clean the inner wall.
  • the sample arm device 7 includes a sample arm holder 701, a sample arm base 702, a sample needle y-direction motor 703, a sample needle y-direction guide 704, a synchronous wheel 705, a driven wheel 706, and a sample needle y.
  • Timing belt 707 sample needle substrate 708, motor pad 709, sample needle z-direction motor 710, sample needle z-direction guide 711, guide rail connection block 712, sample needle z-direction timing belt 713, sample needle 714, sample needle cleaning block 715, Shake z-direction motor 716, Shake z-direction guide 717, Shake z-direction timing belt 718, Shake base 719, Grip motor 720, Push rod connection block 721, Shake main shaft 722, Left claw bracket 723 , Left claw 724, right claw bracket 725, right claw 726, shaker guide 727, clamp timing belt 728, shaker lever 729, shaker motor base 730, and shaker motor 731.
  • each part of the sample arm device 7 is mounted on the sample arm base 702 and connected to the base plate through the sample arm support 701. It includes movements in y and z directions.
  • the y-direction movement is driven by the sample needle y-direction motor 703.
  • the synchronous wheel 705 is installed on the motor shaft.
  • the sample needle y-direction timing belt 707 and the sample arm base 702 are installed.
  • the driven wheel 706 is driven and guided by the sample needle y mounted on the sample arm base 702 to the guide rail 704 to perform y-direction operation.
  • the sample needle 714 is connected to the sample needle z-direction guide 711 through the guide rail connection block 712, and the z-direction sample needle z-direction guide 711 is mounted on the sample needle substrate 708.
  • the sample needle z-direction is connected to the sample needle substrate 708 through the motor pad 709. Driven by the motor 710, the z-direction sample needle z-direction motor 710 is connected to a synchronous wheel 705, a driven wheel 706 mounted on the sample needle base plate 708, and the sample needle z-direction timing belt 713 is driven to realize the z-direction movement of the sample needle 714.
  • the sample needle 714 can be cleaned in a negative pressure flow by a sample needle cleaning block 715 fixed to the sample needle substrate 708.
  • the sample shaker mechanism is driven by a shaker z-direction motor 716 connected to the sample arm base 702 through a motor pad 709, and a synchronous wheel 705 connected to the shaker z-direction motor 716 and a driven wheel mounted on the sample arm base 702. 706 and the shaker z-direction synchronous belt 718 are driven by the shaker z-direction guide rail 717 mounted on the sample arm base 702, and are moved up and down.
  • the shaker base 719 is connected to the shaker z-direction guide 717.
  • a shaker guide 727 is installed on the shaker base 719.
  • the shaker guide 727 has double sliders, and the left and right claw brackets 723 and 725 are respectively mounted on the sliders.
  • the left claw 724 and the right claw 726 are mounted on the left claw bracket 723 and the right claw bracket 725 by shaking the main shaft 722, and the left claw bracket 723 and the right claw bracket 725 are connected to the upper and lower two of the timing belt 728 through a pressure plate.
  • the clamping timing belt 728 is arranged on the driven wheel 706; the clamping motor 720 is connected to the shake base 719, and drives the push rod connection block 721 to move, the push rod connection block 721 is connected to the right claw bracket 725, and the push rod connection block 721 drives the right claw 726 to move, and drives the left claw 724 to move toward each other, so as to realize clamping and releasing of the test tube.
  • the shaker z is started to the motor 716, which drives the left and right side claws and the test tube to rise to the specified height, and the left and right side claws are driven by the shaker lever 729 to swing around the shaker main axis 722 by 0-90 ° to realize the sample. Shake well.
  • the shaker lever 729 is driven by the shaker motor 731, and the shaker motor 731 is mounted on the sample arm base 702 through the shaker motor base 730.
  • the reaction cup shaker device 8 includes a frame, a lifting component, and a shaker component.
  • the rack includes a first fixing plate 801, a second fixing plate 802, a guide post 806, and a cylindrical support post 805.
  • the lifting assembly includes a lifting substrate 803, a connection block 804, a lifting motor 807, and a motor mounting plate 808.
  • the shaker assembly includes a reaction cup shaker 814 and a rotation mechanism.
  • the rotation mechanism includes a mixing motor 809, a motor pad 810, an eccentric post 811, a mixing post 812, a limit pin 813, a support post 815, and a linear bearing 816.
  • the cuvette shaker device 8 is fixed to the bottom frame 1 through a connection block 804 and a first fixing plate 801.
  • the first fixing plate 801, the second fixing plate 802, and a cylindrical support column 805 constitute a frame of the module.
  • the motor mounting plate 808 is fixed to the first fixing plate 801 by a pillar 815.
  • a linear bearing 816 is mounted on the lifting substrate 803, guided by the guide post 806, and driven to the height of the reaction cup by the lifting motor 807.
  • the mixing motor 809 is connected to the lifting substrate 803 through the motor pad 810, and the mixing motor 809 is installed at the shaft end There is an eccentric column 811.
  • the eccentric column 811 is connected to the mixing column 812 through a rolling bearing.
  • the reaction cup shaker 814 is fixed on the mixing column 812, so that the rotary motion is transmitted to the reaction cup shaker 814.
  • the mixing column 812 is composed of The two limiting pins 813 mounted on the lifting substrate 803 limit the rotation angle.
  • the mixing column 812 can only be shaken in a small range in a fixed direction, which drives the shaking of the reaction cup. After mixing for a certain period of time, the mixing motor 809 stops rotating, the lifting motor 807 rotates in the reverse direction, drives the lifting substrate 803 to descend, the reaction cup shaker seat 814 exits the work position, and ends the work flow.
  • the reaction cup lifting device 9 includes a left support plate 901, a right support plate 902, a motor mounting plate 903, a lifting motor 904, a lifting gear 905, a lifting rack 906, a lifting The lifting guide 907, the stopper 908, the optocoupler 909, and the optocoupler 910.
  • the motor mounting plate 903 is fixedly connected to the left and right support plates, and is mounted on the bottom frame through the left and right support plates.
  • the slider of the lifting motor 904 and the lifting rail 907 is mounted on the motor mounting plate 903, the lifting gear 905 is mounted on the lifting motor 904, and the lifting rack is mounted on the guide rail of the lifting rail 907.
  • the 905 drives the lifting rack 906 to lift the reaction cup.
  • the limit stop 908 is mounted on the lifting rack 906 to limit the stroke of the lifting guide.
  • the photocoupler 910 is mounted on the lifting rack, and the photocoupler 909 is mounted on the motor mounting plate 903 for resetting the lifting rack 906.
  • the detection chamber 10 is disposed above the reaction cup lifting device 9, so that the reaction cup lifting device 9 can lift the reaction cup in the incubation tray assembly 2 to the detection chamber 10.
  • the detection room 10 includes a measurement room 1001, a measurement room cover 1002, a PMT mounting plate 1003, a PMT 1004, an alkali connector 1005, a cooling fin 1006, a Peltier 1007, a cooling fin 1008, and a fan 1009. , Measuring room motor 1010, synchronous wheel 1011, measuring room timing belt 1012 and rotating shaft 1013.
  • One side of the measurement room 1001 is connected to the PMT 1004 through a PMT mounting plate 1003 for detecting the luminescence value; the other side is cooled by a Peltier 1007 attached to the cooling sheet 1006 on the cold surface to cool the measurement room 1001 and maintain the measurement room 1001 at a constant temperature.
  • the hot surface of the Peltier 1007 is affixed to the cooling fins 1008, and is radiated by a fan 1009.
  • a rotating wheel is installed in the measuring room 1001 through a bearing and a rotating shaft 1013 (as shown in FIG. 12).
  • the reaction cup is lifted from the lifting inlet 1014 to the reaction cup hole of the rotating wheel of the measuring room 1001.
  • the rotating shaft 1013 is synchronized by the synchronous wheel 1011 and the measuring room.
  • the runner With 1012 transmission, driven by the measurement room motor 1010, the runner is rotated, the reaction cup is rotated to the detection window of PMT1004, and the alkali connector 1005 is injected into the alkali excitation solution to emit light. After the detection is completed, the cuvette is returned to the cuvette tray of the incubation tray assembly 2 through the lifting inlet 1014.
  • the user When using this chemiluminescence detector, the user adds a new reaction cup box from the cup box replacement port, automatically opens the lid through the reaction cup replenishment and recovery device, and adds the reaction cup to the incubation plate with the reagent grasping arm device; open the reagent plate to add Refrigerate and shake the reagents in the kit; then load the sample holder, advance the sample holder and test tube to the sampling point by the sampler, suck the sample by the sample arm, and fill the reaction cup in the incubation tray Then, the reagent in the reagent tray is sucked by the reagent grasping arm, and filled into the same reaction cup, and then the reaction solution in the cup is incubated in the incubation plate, shaken and magnetically separated, and entered through the reaction cup lifting device.
  • reaction cup is used to extract the waste liquid through the waste liquid needle
  • the reaction cup is recovered by the reagent grasping arm to the replenishment and recovery device, thereby realizing the fully automated management of the entire immunoassay process, reducing the intensity of manual operations, and increasing the degree of automation of the instrument To reduce the risk of operator exposure to medical waste.

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Abstract

一种化学发光检测仪，包括：样本进样装置(6)、反应杯补给回收装置(4)、试剂盘(3)、孵育盘组件(2)、检测室(10)以及机械臂系统。机械臂系统包括试剂抓手臂装置(5)和样本臂装置(7)。反应杯补给回收装置(4)能够自动对反应杯(207)进行开盖，并配合试剂抓手臂装置(5)将反应杯(207)添加至孵育盘组件(2)中。试剂盘(3)提供试剂，并配合试剂抓手臂装置(5)将试剂添加至孵育盘组件(2)上的反应杯(207)中。样本进样装置(6)输送样本试管，并配合样本臂装置(7)将样本添加至孵育盘组件(2)上的反应杯(207)中，从而与试剂发生反应，同时，孵育盘组件(2)对反应杯(207)进行一系列处理后传送至检测室(10)进行检测。整个过程自动化程度高，降低人工操作的强度，减小操作人员接触医疗垃圾的风险。

Description

化学发光检测仪 技术领域
本申请涉及生物样本分析检测设备领域，具体而言，涉及一种化学发光检测仪。
背景技术
化学发光检测仪是将具有高灵敏度的化学发光测定技术与高特异性的免疫反应结合，用于各种抗原、抗体、激素和药物等的检测分析技术，是继放免分析、酶免分析、荧光免疫分析之后发展起来的一种最新的免疫检测技术。
现有技术中的免疫检测技术，大多采用自动或者半自动仪器进行检测分析，自动化程度地，人工操作的强度大，接触医疗垃圾的风险较大。
发明内容
本申请的目的在于提供一种化学发光检测仪，自动化程度高，能够减小操作人员接触医疗垃圾的风险。
为了实现上述目的，本申请实施例采用的技术方案如下：
一种化学发光检测仪，包括：样本进样装置，样本进样装置用于输送样本试管；反应杯补给回收装置，反应杯补给回收装置用于输送反应杯以及回收反应杯；试剂盘；试剂盘用于放置试剂盒或样本稀释液；孵育盘组件；孵育盘组件用于放置反应杯补给回收装置输送过来的反应杯，并为反应杯内样本和试剂的反应提供需要的反应温度；检测室；检测室用于对孵育盘反应过的反应液进行检测；以及机械臂系统；机械臂系统包括试剂抓手臂装置和样本臂装置；试剂抓手臂装置设置有用于抓取反应杯的电磁抓手和用于吸取试剂或者废液的吸取针组件；试剂抓手臂装置能够移动至反应杯补给回收装置和孵育盘组件处；样本臂装置能够移动至孵育盘组件和样本进样装置处。
在本申请较佳的实施例中，反应杯升降组件；反应杯升降组件包括第一驱动机构以及至少两个用于容置反应杯盒的反应杯架；第一驱动机构连接于反应杯架，用以驱动反应杯架升降；至少两个反应杯进给组件；每一个反应杯进给组件均包括开盖机构和第二驱动机构；第二驱动机构连接于开盖机构，用以驱动开盖机构移动至反应杯盒的底部进行开盖，并将开盖后的反应杯盒移出或者移回至反应杯架；以及抓手组件； 抓手组件被配置为用于将放置在开盖后的反应杯盒中的反应杯抓取放置于孵育盘；以及将使用过的反应杯夹取放回至开盖后的反应杯盒中。
在本申请较佳的实施例中，反应杯盘，反应杯盘上设置有多个用于放置反应杯的孔位；反应杯盘按周期间歇式旋转；清洗组件，清洗组件包括吸液针组和清洗板组；清洗板组设置在反应杯盘上，吸液针组能够穿过清洗板组伸入反应杯内吸取废液，清洗板组上设置有清洗管组；以及磁性吸附组件，磁性吸附组件包括用于吸附磁珠的磁性吸附部和驱动部；驱动部传动连接于磁性吸附部；其中，驱动部被配置为用于当吸液针组吸取反应杯内的废液之前，驱动磁性吸附部向靠近反应杯的方向运动，以将磁珠吸附在反应杯的侧壁上。
在本申请较佳的实施例中，夹爪组件，夹爪组件包括两个抓手；电磁驱动机构，电磁驱动机构与夹爪组件传动连接，用于驱动夹爪组件的两个抓手相互靠近或者远离，以夹紧或者释放反应杯；以及检测组件，检测组件连接于电磁驱动机构，检测组件根据电磁驱动机构是否复位检测抓手是否抓取到反应杯。
在本申请较佳的实施例中，化学发光检测仪还包括反应杯摇匀装置，反应杯摇匀装置设置在反应杯盘下方，用于对反应杯盘上的反应杯进行震荡摇匀；反应杯摇匀装置包括：机架；机架包括第一固定板、相对设置的第二固定板以及导向柱；导向柱连接在第一固定板和第二固定板之间；升降组件；升降组件设置在第一固定板和第二固定板之间；升降组件能够沿导向柱在第一固定板和第二固定板之间移动；以及摇匀组件；摇匀组件固定连接于升降组件，且摇匀组件穿出于第一固定板；摇匀组件包括用于放置反应杯的反应杯摇匀座以及旋转机构；反应杯摇匀座转动连接于旋转机构。
在本申请较佳的实施例中，反应杯盘的形状大致呈环形，试剂盘设置在环形的反应杯盘内；试剂盘还设置有试剂盒扫描组件。
在本申请较佳的实施例中，化学发光检测仪还包括反应杯举升装置，反应杯举升装置设置在检测室的下方，反应杯举升装置用于将孵育盘组件中的反应杯举升至检测室。
在本申请较佳的实施例中，反应杯举升装置包括举升齿条组件以及举升电机；举升齿条组件传动连接于举升电机，举升齿条组件能够连接于反应杯，并在举升电机的驱动下，将反应杯举升至检测室。
在本申请较佳的实施例中，样本进样装置包括进架机构、退架机构以及试管旋转 轮机构；进架机构用于将放置有样本试管的样本架输送至靠近孵育盘组件；退架机构用于将样本架输送至远离孵育盘组件；试管旋转轮机构用于带动样本架上的每一个试管样本转动扫描样本信息。
在本申请较佳的实施例中，样本进样装置还包括试管推轮机构，试管推轮机构用于压紧样本架上的样本试管，配合试管旋转轮机构旋转扫码。
本申请的有益效果是：
本申请提供的一种化学发光检测仪，包括：样本进样装置、反应杯补给回收装置、试剂盘、孵育盘组件、检测室以及机械臂系统。其中，样本进样装置用于输送样本试管。反应杯补给回收装置用于输送反应杯以及回收反应杯。试剂盘用于放置试剂盒或样本稀释液。孵育盘组件用于放置反应杯补给回收装置输送过来的反应杯，并为反应杯内样本和试剂的反应提供需要的反应温度。检测室用于对孵育盘反应过的反应液进行检测。机械臂系统包括试剂抓手臂装置和样本臂装置；试剂抓手臂装置设置有用于抓取反应杯的电磁抓手和用于吸取试剂或者废液的吸取针组件；试剂抓手臂装置能够移动至反应杯补给回收装置和孵育盘组件处；样本臂装置能够移动至孵育盘组件和样本进样装置处。该仪器，反应杯补给回收装置能够自动对反应杯进行开盖，并配合试剂抓手臂装置将反应杯添加至孵育盘组件中。试剂盘提供试剂，并配合试剂抓手臂装置将试剂添加至孵育盘组件上的反应杯中。样本进样装置输送样本试管，并配合样本臂装置将样本添加至孵育盘组件上的反应杯中，从而与试剂发生反应，同时，孵育盘组件对反应杯进行一系列处理后传送至检测室进行检测。整个过程自动化程度高，降低人工操作的强度，减小操作人员接触医疗垃圾的风险。
附图说明
为了更清楚地说明本申请实施例的技术方案，下面将对实施例中所需要使用的附图作简单地介绍，应当理解，以下附图仅示出了本申请的某些实施例，因此不应被看作是对范围的限定，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他相关的附图。
图1-1为本申请实施例提供的化学发光检测第一视角的结构示意图；
图1-2为本申请实施例提供的化学发光检测仪第二视角的结构示意图；
图2-1是孵育盘组件的分解示意图；
图2-2是孵育盘组件四针清洗站结构示意图；
图2-3是孵育盘组件磁铁推进装置结构示意图；
图3-1是试剂盘的立体示意图；
图3-2是试剂盘的剖视示意图；
图4-1是反应杯补给回收装置的分解示意图；
图4-2是反应杯补给回收装置的进给组件的分解示意图；
图5是试剂抓手臂装置的结构示意图；
图6-1是样本进样装置的结构示意图；
图6-2是样本进样装置的进架机构结构示意图；
图6-3是样本进样装置的退架机构结构示意图；
图6-4是样本进样装置的试管旋转轮机构结构示意图；
图7是试管推轮机构的结构示意图；
图8是样本臂装置的结构示意图；
图9是反应杯摇匀装置的结构示意图；
图10是反应杯举升装置的结构示意图；
图11是检测室的分解示意图；
图12为检测室测量室内的转轮示意图；
图13为电磁抓手的结构示意图。
图标：1-底板框架；101-杯盒更换口；2-孵育盘组件；201-孵育盘支柱；202-孵育盘保温壳；203-温育槽；204-孵育电机；205-孵育主动齿轮；206-反应杯盘；207-反应杯；208-轴承；209-轴承盖；210-孵育盘盖板；211-开闭门；212-开闭门导轨；213-四针清洗站；214-磁铁推进装置；215-加热带；3-试剂盘；301-试剂轴；302-滚动轴承；303-样本试剂盘；304-试剂盒；305-磁珠杯；306-转轮上盖；307-磁珠旋转齿轮；308-恒星齿轮；309-冷却槽；310-保温壳；311-帕尔帖；312-水冷散热器；313-试剂从动齿轮；314-试剂电机；315-试剂主动齿轮；316-电机支架；317-扫码支架；318-扫码器；319-扫码垫板；320-侧边保温棉；321-试剂吸取口；322-试剂盘盖板； 323-开盖传感器；324-活动盖板；325-底部保温棉；326-支柱；4-反应杯补给回收装置；400-反应杯升降组件；410-反应杯进给组件；401-丝杠直线电机；402-导向轴；403-支撑轴；404-反应杯架；4041-顶盖；4042-左侧板；4043-下层挡板；4044-升降架底板；4045-弹片；4046-右侧板；405-反应杯盒；4052-塑料托架；406-导向轴压板；407-导向轴连接块；408-直线轴承；409-轴用挡圈；410-反应杯进给组件；411-电机；412-电机支撑座；413-电机安装板；414-导轨垫板；415-直线导轨；416-托板；417-光耦片；418-定位销；419-从动齿条；420-驱动齿轮；5-试剂抓手臂装置；501-抓手臂支架；502-抓手臂基座；503-抓手臂x向电机；504-抓手臂x向导轨；505-同步轮；506-抓手臂x向同步带；507-抓手臂z向基座；508-抓手臂z向电机；509-从动轮；510-抓手臂z向同步带；511-抓手臂z向导轨；512-抓手座；513-电磁抓手；5131-夹爪组件；5132-电磁驱动机构；5133-检测组件；5134-抓手基板；514-试剂针座；515-试剂针；516-试剂针清洗块；517-废液针组件；518-废液针；6-样本进样装置；601-六角支柱；602-进架机构；6021-进架导轨座；6022-进架导轨；6023-推入滑座；6024-推入钩；6025-进架电机支座；6026-进架电机；6027-进架同步带；603-从动轮；604-X向推架导轨；605-推架同步带；606-推杆连接块；607-退架机构；6071-退架导轨座；6072-退架电机；6073-退架拨杆；6074-推块销；6075-退架导轨；6076-退架滑座；6077-退架同步带；608-同步轮；609-推架电机支架；6011-退架导轨座；610-推架电机；611-试管推杆；612-样本架及试管；613-试管旋转轮机构；6131-旋转轮电机；6132-电机支座；6133-旋转轮底座；6134-轴承座；6135-橡胶轮；6136-旋转轮同步带；6137-旋转轴；614-进样器托盘；1700-试管推轮机构；1701-推轮基座；1702-推轮导轨；1703-推轮丝杠电机；1704-推轮连接座；1705-推轮连杆；1706-清洗池座；1707-旋转轴承；1708-扫码器；1709-样本针清洗池；1710-推轮支架；1711-扫码器支架；7-样本臂装置；701-样本臂支架；702-样本臂基座；703-样本针y向电机；704-样本针y向导轨；705-同步轮；706-从动轮；707-样本针y向同步带；708-样本针基板；709-电机垫板；710-样本针z向电机；711-样本针z向导轨；712-导轨连接块；713-样本针z向同步带；714-样本针；715-样本针清洗块；716-摇匀z向电机；717-摇匀z向导轨；718-摇匀z向同步带；719-摇匀基座；720-夹取电机；721-推杆连接块；722-摇匀主轴；723-左爪支架；724-左侧爪；725-右爪支架；726-右侧爪；727-摇匀导轨；728-夹取同步带；729-摇匀拨杆；730-摇匀电机座；731-摇匀电机；8-反应杯摇匀装置；801-第一固定板；802-第二固定板；803-升降基板；804-连接块；805-圆柱支撑柱；806-导向柱；807-升降电机；808-电机安装板；809-混匀电机；810-电机垫板；811-偏心柱； 812-混匀柱；813-限位钉；814-反应杯摇匀座；815-支柱；816-直线轴承；9-反应杯举升装置；901-左侧支撑板；902-右侧支撑板；903-电机安装板；904-举升电机；905-举升齿轮；906-举升齿条；907-举升导轨；908-限位挡片；909-光耦；910-光耦片；10-检测室；1001-测量室；1002-测量室盖板；1003-PMT安装板；1004-PMT；1005-碱接头；1006-致冷片；1007-帕尔帖；1008-散热翅；1009-风扇；1010-测量室电机；1011-同步轮；1012-测量室同步带；1013-转轴；1014-升降入口。
具体实施方式
为使本申请实施例的目的、技术方案和优点更加清楚，下面将结合本申请实施例中的附图，对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本申请一部分实施例，而不是全部的实施例。通常在此处附图中描述和示出的本申请实施例的组件可以以各种不同的配置来布置和设计。
因此，以下对在附图中提供的本申请的实施例的详细描述并非旨在限制要求保护的本申请的范围，而是仅仅表示本申请的选定实施例。基于本申请中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本申请保护的范围。
应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步定义和解释。
在本申请实施例的描述中，需要说明的是，术语“上”、“内”等指示的方位或位置关系为基于附图所示的方位或位置关系，或者是该申请产品使用时惯常摆放的方位或位置关系，仅是为了便于描述本申请和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请的限制。
在本申请的描述中，还需要说明的是，除非另有明确的规定和限定，术语“设置”、“安装”、“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本申请中的具体含义。
请参照图1-1～图13，本实施例提供一种化学发光检测仪，其包括底板框架1、孵育盘组件2、试剂盘3、反应杯补给回收装置4、机械臂系统、样本进样装置6、反应杯摇匀装置8、反应杯举升装置9以及检测室10。其中，机械臂系统包括试剂抓手 臂装置5和样本臂装置7。该化学发光检测仪，反应杯补给回收装置4能够自动对反应杯进行开盖，并配合试剂抓手臂装置5将反应杯添加至孵育盘组件2中。试剂盘3提供试剂，并配合试剂抓手臂装置5将试剂添加至孵育盘组件2上的反应杯中。样本进样装置6输送样本试管，并配合样本臂装置7将样本添加至孵育盘组件2上的反应杯中，从而与试剂发生反应，同时，孵育盘组件2对反应杯进行温育、震荡摇匀及磁性分离。反应杯举升装置9将经过孵育盘组件2上一系列处理后的反应杯传送至检测室10进行检测。整个过程自动化程度高，降低人工操作的强度，减小操作人员接触医疗垃圾的风险。
进一步地，参照图1-1～图1-2，底板框架1作为整个化学发光检测仪的基体，孵育盘组件2、试剂盘3、反应杯补给回收装置4、试剂抓手臂装置5、样本进样装置6、样本臂装置7、反应杯摇匀装置8、反应杯举升装置9以及检测室10均安装在该底板框架1上。
进一步地，如图2-1所示，孵育盘组件2包含反应杯盘206、清洗组件以及磁性吸附组件。在本实施例中，清洗组件选择四针清洗站213。磁性吸附组件选择磁铁推进装置214。进一步地，孵育盘组件2还包括孵育盘支柱201、孵育盘保温壳202、温育槽203、孵育电机204、孵育主动齿轮205、反应杯207、轴承208、轴承盖209、孵育盘盖板210、开闭门211(同时也是加试剂、加杯位)、开闭门导轨212、及加热带215。孵育盘组件2的温育槽203通过螺钉连接于若干孵育盘支柱201，并固定于底板上，盘外侧布置孵育盘保温壳202，并通过保温棉减少热量散失，进行保温。孵育电机204安装于温育槽203上，电机轴上连接有孵育主动齿轮205；轴承208内圈由轴承盖209固定于温育槽203，外圈承载反应杯盘206，反应杯盘206既能装载若干反应杯，又作为齿轮，与孵育主动齿轮205相啮合，由孵育电机204驱动反应杯盘206旋转，从而带动盘中的反应杯到达加样位、加试剂位。孵育盘盖板210由螺钉固连于温育槽203顶部，孵育盘盖板210上通过开闭门导轨212安装有开闭门211，开闭门211既作为加试剂位，又作为反应杯的添加位，它由试剂抓手臂装置5推开，由复位弹簧关闭。孵育盘盖板210还布置有加样位。加热带215夹在孵育盘保温壳202与温育槽203之前，贴于温育槽203的底部，为孵育盘制热，温育槽203的内部布置有磁铁推进装置214，磁铁推进装置214包括用于吸附磁珠的磁性吸附部和驱动部。具体地，驱动部为丝杠电机，磁性吸附部能够在丝杠电机的驱动下靠近或者远离反应杯盘。如图2-3所示，由丝杠电机提供动力，由双导轨导向，实现磁场的加载与撤离；磁铁推进装置214的正上方，有固定于温育槽203顶部的四针清洗站213，其结构示 意图如图2-2所示，四针清洗站213采用丝杠电机提供动力，由直线导轨导向，实现清洗针的上下运动，由蠕动泵连接于清洗针进行清洗废液的抽取，由柱塞泵实现清洗液的加注。四针清洗站213、磁铁推进装置214共同实现仪器的磁性分离功能。四针清洗站213上还布置有酸接头，用于加注酸激发液至反应杯。
进一步地，如图3-1及3-2，试剂盘3包括：试剂轴301、滚动轴承302、样本试剂盘303、试剂盒304、磁珠杯305、转轮上盖306、磁珠旋转齿轮307、恒星齿轮308、冷却槽309、保温壳310、帕尔帖311、水冷散热器312、试剂从动齿轮313、试剂电机314、试剂主动齿轮315、电机支架316、扫码支架317、扫码器318、扫码垫板319、侧边保温棉320、试剂盘盖板322、开盖传感器323、活动盖板324、底部保温棉325、支柱326及试剂复位光耦及码盘。
试剂盘3布置于孵育盘组件2的内环中，通过若干支柱326固定于底板框架1上，其保温壳310贴有侧边保温棉320及底部保温棉325，阻止热量交换。试剂盘盖板322固定于冷却槽309上，活动盖板324则放置于冷却槽上，可通过开盖传感器323感知活动盖板324是否打开。进一步地，试剂盘3还设置有试剂盒扫描组件。具体地，在本实施例中，试剂盘盖板322上布置有电机支架316，上面固定有扫码器318，扫码器318通过固定于试剂盘盖板322上的扫码垫板319的窗口进行扫码。试剂盘盖板322上预留有试剂吸取口321。
试剂盘内部构造为：试剂电机314经电机支架316固定于冷却槽309，试剂主动齿轮315安装于试剂电机314的主轴，驱动试剂从动齿轮313带动试剂轴301旋转。试剂轴301通过滚动轴承302安装于冷却槽309中心孔，样本试剂盘303则通过螺钉固连于试剂轴301。样本试剂盘303布置有试剂盒304，每个试剂盒304的末位放置有磁珠杯305，由转轮上盖306托起，转轮上盖连接于磁珠旋转齿轮307上，磁珠旋转齿轮307安装于样本试剂盘303的轴孔中，与固定于冷却槽309的恒星齿轮308啮合，形成行星轮系，磁珠旋转齿轮307围绕恒星齿轮308公转的同时，也进行自转，带动托起磁珠杯305的转轮上盖306旋转，达到混匀磁珠杯305中的试剂的目的。另外，由于试剂盘3需要冷藏试剂，故采用帕尔帖制冷的方法，帕尔帖311冷面贴于冷却槽309给试剂盘制冷，热面贴于水冷散热器312，由水冷散热器312及布置于底板框架1的水冷排为其散热。
进一步地，反应杯补给回收装置4包含反应杯升降组件400及至少两套反应杯进给组件410。第一驱动机构连接于反应杯架，用以驱动反应杯架升降。如图4-1所示， 反应杯升降组件包括第一驱动机构以及至少两个用于容置反应杯盒405的反应杯架404。具体地，在本实施例中，第一驱动机构为丝杠直线电机401。进一步地，反应杯升降组件还包括导向轴402，支撑轴403、导向轴压板406、导向轴连接块407、直线轴承408以及轴用挡圈409。进一步地，反应杯架404包括顶盖4041、左侧板4042、下层挡板4043、升降架底板4044、弹片4045以及右侧板4046。反应杯升降组件400的工作过程是，反应杯架404安装于导向轴连接块407的的两侧，丝杠直线电机401提供动力，使导向轴连接块407及反应杯架404沿着导向轴402上下升降，至底板框架1的杯盒更换口101，由操作者将反应杯盒405沿着更换口添加至反应杯架404中，反应杯架404的左侧板4042及右侧板4046上的滑槽保证反应杯盒405在反应杯架404中初步定位，通过弹片4045将反应杯盒固定于反应杯架404中。接着反应杯升降组件400进行升降，将反应杯架404下降至指定高度，由反应杯进给组件410将反应杯盒405开盖，钩取出反应杯盒405的塑料托架4052及其中的反应杯，供试剂抓手臂装置5抓取反应杯。
如图4-2所示，反应杯进给组件410包括开盖机构和第二驱动机构；第二驱动机构连接于开盖机构，用以驱动开盖机构移动至反应杯盒的底部进行开盖，并将开盖后的反应杯盒移出或者移回至反应杯架。具体地，在本实施例中，第二驱动机构为电机411。开盖机构包括托板416和定位销418。通过定位销418进行开盖。进一步地，反应杯进给组件410还包括电机支撑座412、电机安装板413、导轨垫板414、直线导轨415、光耦片417、从动齿条419以及驱动齿轮420。反应杯进给组件410的工作过程是，电机411提供动力，由驱动齿轮420及从动齿条419传输动力，通过直线导轨415进行导向，由定位销418给反应杯盒405开盖，钩取出塑料托架4052及其中的反应杯，并输送至试剂抓手臂装置5下方进行反应杯的抓取。另外，使用过的反应杯也经由试剂抓手臂装置5的电磁抓手513回收至反应杯进给组件410上的开盖反应杯盒405中，然后回到反应杯升降组件400中的反应杯架404中，由反应杯升降组件400运行至更换口进行反应杯盒405的更换。
该反应杯补给回收装置4，用户只需要从更换口处添加反应杯盒405，就可以自动开盖将反应杯输送至抓手试剂臂下，通过电磁抓手513添加至孵育盘中。在反应杯使用完之后再通过电磁抓手513将反应杯抓取至反应杯盒405中进行回收，提高仪器的自动化程度以及减小操作人员接触医疗垃圾的风险。
进一步地，如图5所示，试剂抓手臂装置5包含抓手臂支架501、抓手臂基座502、抓手臂x向电机503、抓手臂x向导轨504、同步轮505、抓手臂x向同步带506、抓 手臂z向基座507、抓手臂z向电机508、从动轮509、抓手臂z向同步带510、抓手臂z向导轨511、抓手座512、电磁抓手513、试剂针座514、试剂针515、试剂针清洗块516及废液针组件517。试剂抓手臂装置5的零件均安装于抓手臂基座502，并由抓手臂支架501安装于底板框架1。它包含x与z两个方向的运动，其x向运动由抓手臂x向电机503驱动，同步轮505安装于电机轴，经x向同步带及安装于抓手臂基座502上的从动轮509传动，由安装于抓手臂基座502上的抓手臂x向导轨504导向，进行x向运行。电磁抓手513通过抓手座512、试剂针515通过试剂针座514连接于抓手臂z向导轨511上，抓手臂z向导轨511安装于抓手臂z向基座507，通过安装于抓手臂z向基座507的抓手臂z向电机508驱动，经连接于z向抓手臂z向电机508的同步轮505、安装于抓手臂z向基座507的从动轮509及抓手臂z向同步带510传动，实现电磁抓手513及试剂针515的z向运动，以实现电磁抓手513的反应杯抓取及试剂针515的试剂吸取等流程。试剂针515通过固定于抓手臂z向基座507的试剂针清洗块516进行负压流式清洗。此外，在一侧的抓手臂支架501上，还安装有废液针组件517，该组件通过丝杠电机驱动，经直线导轨传动，带动废液针518下降吸取反应杯中的废液。
进一步地，如图13所示，电磁抓手513包括夹爪组件5131、电磁驱动机构5132、检测组件5133以及抓手基板5134。具体地，夹爪组件5131包括两个抓手。电磁驱动机构5132与夹爪组件5131传动连接，用于驱动夹爪组件5131的两个抓手相互靠近或者远离，以夹紧或者释放反应杯。检测组件5133连接于电磁驱动机构5132，检测组件根据电磁驱动机构5132是否复位检测抓手是否抓取到反应杯。电磁驱动机构体积较小，控制系统简单，不需要配置气源装置，结构紧凑，成本较低。检测组件的设置，进一步保证了整个电磁抓手装置抓取反应杯的稳定可靠性。
进一步地，如图6-1所示，样本进样装置6包含六角支柱601、进架机构602、从动轮603、X向推架导轨604、推架同步带605、推杆连接块606、退架机构607、同步轮608、推架电机支架609、推架电机610、试管推杆611、样本架及试管612、试管旋转轮机构613及进样器托盘614。整个进样器通过六角支柱601安装于底板，进样器托盘614安装于六角支柱601上，供用户放置样本架。其中x向推架机构由推架电机610驱动，推架电机610安装有同步轮608，通过推架电机支架609安装于底板，经推架同步带605及从动轮603传动，由安装于底板的X向推架导轨604导向，进行x向运动。推杆连接块606安装于X向推架导轨604上，其上固连有试管推杆611，带动样本架及试管612沿x向运动。
如图6-2所示，进架机构602包含进架导轨座6021、进架导轨6022、推入滑座6023、推入钩6024、进架电机支座6025、进架电机6026、进架同步带6027。进架机构602通过进架导轨座6021安装于底板，进架电机6026通过进架电机支座6025连接于进架导轨座6021，通过安装于进架电机6026轴上的同步轮608、进架同步带6027及从动轮603传动，由安装于进架导轨座6021的进架导轨6022导向，驱动安装于进架导轨6022上的推入滑座6023运动，推入钩6024安装于推入滑座6023上，用于推动样本架进架。
如图6-3所示，退架机构607包含退架导轨座6071、退架电机6072、退架拨杆6073、推块销6074、退架导轨6075、退架滑座6076、退架同步带6077。退架机构607通过退架导轨座6071安装于底板，退架电机6072固定于退架导轨座6071，通过安装于退架电机6072轴上的同步轮608、退架同步带6077及从动轮603传动，由安装于退架导轨座6011的退架导轨6075导向，驱动安装于退架导轨6075上的退架滑座6076运动，退架滑座6076上通过推块销6074安装有退架拨杆6073，用于推动样本架退出。
如图6-4所示，试管旋转轮机构613包含旋转轮电机6131、电机支座6132、旋转轮底座6133、轴承座6134、橡胶轮6135、旋转轮同步带6136及旋转轴6137。试管旋转轮机构613通过六角支柱601将旋转轮底座6133安装于底板，旋转轮电机6131通过电机支座6132安装于旋转轮底座6133上，通过同步轮608及旋转轮同步带6136传动，驱动旋转轴6137旋转，旋转轴6137通过两个轴承安装于轴承座6134中，并固定在旋转轮底座6133上，旋转轴6137的另一端安装有橡胶轮6135，从而带动试管旋转。
如图7所示，试管推轮机构1700包含推轮基座1701、推轮导轨1702、推轮丝杠电机1703、推轮连接座1704、推轮连杆1705、清洗池座1706、旋转轴承1707、扫码器1708、样本针清洗池1709、推轮支架1710及扫码器支架1711。试管推轮机构1700通过推轮基座1701安装于底板，其上安装有推轮导轨1702，推轮支架1710安装于推轮导轨1702上，通过推轮丝杠电机1703驱动，经推轮连接座1704将动力传动至推轮支架1710，使推轮支架1710沿推轮连杆1705在推轮导轨1702上运动，推动安装于推轮支架1710上的旋转轴承1707压紧样本架中的试管，供试管旋转轮机构613旋转扫码。扫码器1708通过扫码器支架1711安装于推轮基座1701上。最后样本针清洗池1709通过清洗池座1706安装于扫码器支架1711上，供样本针清洗内壁。
进一步地，如图8所示，样本臂装置7包含样本臂支架701、样本臂基座702、样本针y向电机703、样本针y向导轨704、同步轮705、从动轮706、样本针y向同步带707、样本针基板708、电机垫板709、样本针z向电机710、样本针z向导轨711、导轨连接块712、样本针z向同步带713、样本针714、样本针清洗块715、摇匀z向电机716、摇匀z向导轨717、摇匀z向同步带718、摇匀基座719、夹取电机720、推杆连接块721、摇匀主轴722、左爪支架723、左侧爪724、右爪支架725、右侧爪726、摇匀导轨727、夹取同步带728、摇匀拨杆729、摇匀电机座730及摇匀电机731。
进一步地，样本臂装置7的各个零件安装于样本臂基座702，通过样本臂支架701连接于底板上。它包含y与z两个方向的运动，其y向运动由样本针y向电机703驱动，同步轮705安装于电机轴，经样本针y向同步带707及安装于样本臂基座702上的从动轮706传动，由安装于样本臂基座702上的样本针y向导轨704导向，进行y向运行。样本针714通过导轨连接块712连接于样本针z向导轨711上，z向样本针z向导轨711安装于样本针基板708，由通过电机垫板709连接于样本针基板708的样本针z向电机710驱动，经连接于z向样本针z向电机710的同步轮705、安装于样本针基板708的从动轮706及样本针z向同步带713传动，实现样本针714的z向运动。样本针714可通过固定于样本针基板708的样本针清洗块715进行负压流式清洗。样本摇匀机构由通过电机垫板709连接于样本臂基座702的摇匀z向电机716驱动，经连接于摇匀z向电机716的同步轮705、安装于样本臂基座702的从动轮706及摇匀z向同步带718传动，由安装于样本臂基座702的摇匀z向导轨717导向，进行上下升降。摇匀基座719连接于摇匀z向导轨717，摇匀基座719上安装有摇匀导轨727，摇匀导轨727具有双滑块，滑块上分别安装左爪支架723及右爪支架725，左侧爪724与右侧爪726通过摇匀主轴722安装于左爪支架723与右爪支架725上，且左爪支架723与右爪支架725通过压板连接于夹取同步带728的上下两侧，夹取同步带728布置于从动轮706上；夹取电机720连接于摇匀基座719，驱动推杆连接块721运动，推杆连接块721连接于右爪支架725，推杆连接块721带动右侧爪726运动，并带动左侧爪724相向运动，以实现试管的夹取与松开。当试管夹取后，摇匀z向电机716启动，带动左右侧爪及试管上升至指定高度，由摇匀拨杆729驱动左右侧爪绕摇匀主轴722做0-90°的摆动，实现样本的摇匀。由摇匀拨杆729由摇匀电机731驱动，摇匀电机731通过摇匀电机座730安装于样本臂基座702。
进一步地，如图9所示，反应杯摇匀装置8包含机架、升降组件以及摇匀组件。 具体地，机架包括第一固定板801、第二固定板802、导向柱806、以及圆柱支撑柱805。升降组件包括升降基板803、连接块804、升降电机807、电机安装板808。摇匀组件包括反应杯摇匀座814和旋转机构。具体地，旋转机构包括混匀电机809、电机垫板810、偏心柱811、混匀柱812、限位钉813、支柱815及直线轴承816。反应杯摇匀装置8通过连接块804及第一固定板801固定于底板框架1，由第一固定板801、第二固定板802及圆柱支撑柱805构成该模块的框架，升降电机807安装于电机安装板808，通过支柱815固定于第一固定板801。升降基板803上安装有直线轴承816，经导向柱806导向，通过升降电机807驱动升降至反应杯的高度，混匀电机809通过电机垫板810连接于升降基板803，混匀电机809轴端安装有偏心柱811，偏心柱811通过一个滚动轴承连接于混匀柱812，反应杯摇匀座814固定于混匀柱812上，从而将旋转运动传递至反应杯摇匀座814，混匀柱812由安装于升降基板803上的两个限位钉813限制转动角度。使混匀柱812只能在固定方向进行小范围的晃动，带动了反应杯的晃动。在一定时长混匀后，混匀电机809停止转动，升降电机807反向旋转，驱动升降基板803下降，反应杯摇匀座814退出工作位，结束工作流程。
进一步地，如图10所示、反应杯举升装置9包含左侧支撑板901、右侧支撑板902、电机安装板903、举升电机904、举升齿轮905、举升齿条906、举升导轨907、限位挡片908、光耦909、光耦片910。电机安装板903固连于左、右侧支撑板，通过左、右侧支撑板安装于底板框架上。举升电机904、举升导轨907的滑块安装于电机安装板903上，举升齿轮905安装于举升电机904上，举升齿条安装于举升导轨907的导轨上，通过举升齿轮905驱动举升齿条906举升反应杯。限位挡片908安装于举升齿条906上，限制举升导轨行程。光耦片910安装于举升齿条，光耦909安装于电机安装板903，用于举升齿条906的复位。
进一步地，如图11所示，检测室10设置在反应杯举升装置9上方，从而使得反应杯举升装置9能够将将孵育盘组件2中的反应杯举升至检测室10。具体地，在本实施例中，检测室10包含测量室1001、测量室盖板1002、PMT安装板1003、PMT1004、碱接头1005、致冷片1006、帕尔帖1007、散热翅1008、风扇1009、测量室电机1010、同步轮1011、测量室同步带1012及转轴1013。测量室1001一侧通过PMT安装板1003连接PMT1004，用于检测发光值；另一侧通过冷面贴于致冷片1006的帕尔帖1007为测量室1001制冷，保持测量室1001恒温。帕尔帖1007的热面贴于散热翅1008，通过风扇1009为其散热。测量室1001内通过轴承及转轴1013安装有转轮(如图12)，反应杯由升降入口1014被举升至测量室1001的转轮的反应杯孔，转轴1013通过同 步轮1011及测量室同步带1012传动，经测量室电机1010驱动，使转轮旋转，将反应杯转动至PMT1004的检测窗口，由碱接头1005注入碱激发液进行发光。检测完成后反应杯由升降入口1014回到孵育盘组件2的反应杯盘中。
该化学发光检测仪，使用时，用户从杯盒更换口处添加新反应杯盒，通过反应杯补给回收装置自动开盖，配合试剂抓手臂装置将反应杯添加至孵育盘中；打开试剂盘加入试剂盒，让试剂盒中的试剂冷藏及摇匀；接着载入样本架，由进样器将样本架及试管推进至吸样点，由样本臂吸取样本，并加注于孵育盘的反应杯中，再由试剂抓手臂吸取试剂盘中的试剂，加注于同一反应杯中，随即杯中的反应液在孵育盘中进行温育、震荡摇匀及磁性分离，经由反应杯举升装置进入检测室进行检测。使用过的反应杯经废液针抽取废液后，由试剂抓手臂将反应杯回收至补给回收装置，从而实现整个免疫分析过程的全自动化管理，降低人工操作的强度，提高了仪器的自动化程度，减小操作人员接触医疗垃圾的风险。
以上所述仅为本申请的优选实施例而已，并不用于限制本申请，对于本领域的技术人员来说，本申请可以有各种更改和变化。凡在本申请的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本申请的保护范围之内。应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步定义和解释。

Claims (10)

  1. 一种化学发光检测仪，其特征在于，包括：
    样本进样装置，所述样本进样装置用于输送样本试管；
    反应杯补给回收装置，所述反应杯补给回收装置用于输送反应杯以及回收所述反应杯；
    试剂盘；所述试剂盘用于放置试剂盒或样本稀释液；
    孵育盘组件；所述孵育盘组件用于放置所述反应杯补给回收装置输送过来的所述反应杯，并为所述反应杯内样本和试剂的反应提供需要的反应温度；
    检测室；所述检测室用于对所述孵育盘组件反应过的反应液进行检测；以及
    机械臂系统；所述机械臂系统包括试剂抓手臂装置和样本臂装置；所述试剂抓手臂装置设置有用于抓取反应杯的电磁抓手和用于吸取试剂或者废液的吸取针组件；所述试剂抓手臂装置能够移动至所述反应杯补给回收装置和所述孵育盘组件处；所述样本臂装置能够移动至所述孵育盘组件和所述样本进样装置处。
  2. 如权利要求1所述的化学发光检测仪，其特征在于，所述反应杯补给回收装置包括：
    反应杯升降组件；所述反应杯升降组件包括第一驱动机构以及至少两个用于容置反应杯盒的反应杯架；所述第一驱动机构连接于所述反应杯架，用以驱动所述反应杯架升降；以及
    至少两个反应杯进给组件；每一个所述反应杯进给组件均包括开盖机构和第二驱动机构；所述第二驱动机构连接于所述开盖机构，用以驱动所述开盖机构移动至所述反应杯盒的底部进行开盖，并将开盖后的所述反应杯盒移出或者移回至所述反应杯架。
  3. 如权利要求1所述的化学发光检测仪，其特征在于，所述孵育盘组件包括：
    反应杯盘，所述反应杯盘上设置有多个用于放置反应杯的孔位；所述反应杯盘按周期间歇式旋转；
    清洗组件，所述清洗组件包括吸液针组和清洗板组；所述清洗板组设置在所述反应杯盘上，所述吸液针组能够穿过所述清洗板组伸入所述反应杯内吸取废液，所述清洗板组上设置有清洗管组；以及
    磁性吸附组件，所述磁性吸附组件包括用于吸附磁珠的磁性吸附部和驱动部；所述驱动部传动连接于所述磁性吸附部；
    其中，所述驱动部被配置为用于当所述吸液针组吸取所述反应杯内的废液之前，驱动所述磁性吸附部向靠近所述反应杯的方向运动，以将所述磁珠吸附在所述反应杯的侧壁上。
  4. 如权利要求1所述的化学发光检测仪，其特征在于，所述电磁抓手包括：
    夹爪组件，所述夹爪组件包括两个抓手；
    电磁驱动机构，所述电磁驱动机构与所述夹爪组件传动连接，用于驱动所述夹爪组件的两个所述抓手相互靠近或者远离，以夹紧或者释放反应杯；以及
    检测组件，所述检测组件连接于所述电磁驱动机构，所述检测组件根据所述电磁驱动机构是否复位检测所述抓手是否抓取到所述反应杯。
  5. 如权利要求3所述的化学发光检测仪，其特征在于，所述化学发光检测仪还包括反应杯摇匀装置，所述反应杯摇匀装置设置在所述反应杯盘下方，用于对所述反应杯盘上的所述反应杯进行震荡摇匀；
    所述反应杯摇匀装置包括：
    机架；所述机架包括第一固定板、相对设置的第二固定板以及导向柱；所述导向柱连接在所述第一固定板和所述第二固定板之间；
    升降组件；所述升降组件设置在所述第一固定板和所述第二固定板之间；所述升降组件能够沿所述导向柱在所述第一固定板和所述第二固定板之间移动；以及
    摇匀组件；所述摇匀组件固定连接于所述升降组件，且所述摇匀组件穿出于所述第一固定板；所述摇匀组件包括用于放置反应杯的反应杯摇匀座以及旋转机构；所述反应杯摇匀座转动连接于所述旋转机构。
  6. 如权利要求5所述的化学发光检测仪，其特征在于，
    所述反应杯盘的形状大致呈环形，所述试剂盘设置在环形的所述反应杯盘内；所述试剂盘还设置有试剂盒扫描组件。
  7. 如权利要求1-6任一项所述的化学发光检测仪，其特征在于，
    所述化学发光检测仪还包括反应杯举升装置，所述反应杯举升装置设置在所述检测室的下方，所述反应杯举升装置用于将所述孵育盘组件中的所述反应杯举升至所述检测室。
  8. 如权利要求7所述的化学发光检测仪，其特征在于，
    所述反应杯举升装置包括举升齿条组件以及举升电机；所述举升齿条组件传 动连接于所述举升电机，所述举升齿条组件能够连接于所述反应杯，并在所述举升电机的驱动下，将所述反应杯举升至所述检测室。
  9. 如权利要求1所述的化学发光检测仪，其特征在于，
    所述样本进样装置包括进架机构、退架机构以及试管旋转轮机构；所述进架机构用于将放置有样本试管的样本架输送至靠近所述孵育盘组件；所述退架机构用于将所述样本架输送至远离所述孵育盘组件；所述试管旋转轮机构用于带动所述样本架上的每一个所述试管样本转动扫描样本信息。
  10. 如权利要求9所述的化学发光检测仪，其特征在于，
    所述样本进样装置还包括试管推轮机构，所述试管推轮机构用于压紧所述样本架上的所述样本试管，配合所述试管旋转轮机构旋转扫码。
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CN208833787U (zh) * 2018-09-28 2019-05-07 基蛋生物科技股份有限公司 化学发光检测仪

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