WO2020057195A1 - 体外定量检测仪器 - Google Patents
体外定量检测仪器 Download PDFInfo
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- WO2020057195A1 WO2020057195A1 PCT/CN2019/091430 CN2019091430W WO2020057195A1 WO 2020057195 A1 WO2020057195 A1 WO 2020057195A1 CN 2019091430 W CN2019091430 W CN 2019091430W WO 2020057195 A1 WO2020057195 A1 WO 2020057195A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
Definitions
- the present application relates to the field of external quantitative detection, in particular to an in vitro quantitative detection instrument.
- In vitro quantitative detection equipment can quantitatively detect human serum, plasma, whole blood or urine. For clinical auxiliary diagnosis.
- test tube of the in vitro quantitative detection instrument does not need to be shaken to open the cover, and the cover needs to be manually shaken to remove the cover.
- the size of the machine is too large and the weight is too heavy.
- the purpose of the present application is to provide an in vitro quantitative detection instrument, which does not need to manually open the lid of the test tube and shake it to cover it, and has a high degree of automation.
- An in vitro quantitative detection instrument includes: a sample injection device, the sample injection device is used for transporting a test tube rack for placing a sample test tube; and a shake opening device, the shake opening device is arranged near the sample injection device, and the shutter is opened
- the device is used for opening, shaking, and closing the sample test tubes transported by the sample injection device;
- the reagent container transport device the reagent container transport device includes a plurality of reagent cartridge storage components and reagent cartridge transport mechanisms; incubation and detection components; and
- the robotic arm is connected with a liquid suction needle group, and the robotic arm can transport the liquid suction needle group to a sample sampling device, a reagent box transportation device, and an incubation and detection component.
- the shake-opening device includes: a support portion; a cover-opening mechanism, the cover-opening mechanism is connected to one side of the support portion; the cover-opening mechanism includes a cover-opening jaw, a first driving component, a first Two driving components and a third driving component; the first driving component, the second driving component, and the third driving component are all drivingly connected to the lid opening jaw; the first driving component is used for driving the lid opening jaw to clamp or release the sample test tube Cover; the second drive component is used to drive the lid opening jaw to rotate; the third drive component is used to drive the lid opening jaw to move up and down relative to the support; shake mechanism, the shake mechanism is connected to the other side of the support; The mechanism includes a clamping component, a fourth driving component, a fifth driving component, and a sixth driving component; the fourth driving component, the fifth driving component, and the sixth driving component are all drivingly connected to the clamping component; the clamping component is used for clamping The sample test tube; the fourth driving component is
- the cover-opening clamping jaw includes at least three supporting jaws; the output shaft of the first driving component is connected with at least three inclined planes; and the connecting ends of the at least three supporting jaws are provided with matching connections with the inclined planes.
- the first driving component moves, at least three supporting claws are driven to slide along the inclined surface, so that at least three supporting claws approach or move away from each other.
- the clamping assembly includes a swinging member, a first clamping section and a second clamping section; the swinging member is connected to the first clamping section; the second clamping section is drivingly connected to the fifth drive Component; the first clamping portion and the second clamping portion are oppositely arranged.
- the first clamping portion is fixedly connected to the fourth driving component, and when the fourth driving component moves, the first clamping portion is moved to move the first clamping portion toward or away from the second Clamping section.
- the reagent cartridge storage assembly includes a plurality of receiving chambers for storing the reagent cartridges and a cartridge case; each cartridge contains a cartridge case; a plurality of reagents The boxes are stacked in the magazine housing.
- the kit transport mechanism includes a gripping component, a moving track, and a driving component; the gripping component is used to remove the reagent cartridge from the cartridge housing; the gripping component is drivingly connected to the driving component, To drive the gripping component to move along the moving track.
- the sample sampling device includes a driving part, a moving guide rail, and a plurality of supporting plates for placing test tube racks; the driving part is drivingly connected to the moving guide rail; each supporting plate is connected to the moving guide rail.
- the sample sampling device further includes a code scanning component.
- the code scanning component is disposed near the shaker and opening device; the code scanning component is used for scanning the sample information in the test tube rack.
- the in vitro quantitative detection instrument further includes a casing, the casing having a first end and an opposite second end; the sample sampling device is disposed at the first end, and the incubation component and the detection component are disposed at The second end, the robot arm is disposed between the first end and the second end.
- An in vitro quantitative detection instrument includes a sample sampling device, a shaker and lid opening device, a reagent cartridge transport device, an incubation and detection component, and a robot arm.
- the sample injection device is used for transporting a test tube rack in which sample test tubes are placed.
- the shaking and opening device is arranged close to the sample sampling device.
- the shaking and opening device is used to open and shake and close the sample test tube transported by the sample injection device.
- the kit transporting device includes a plurality of kit storage components and a kit transport mechanism.
- the robotic arm is connected with a liquid aspiration needle group, and the robotic arm can transport the liquid aspiration needle group to a sample sampling device, a reagent box transportation device, and an incubation and detection component.
- the in vitro quantitative detection instrument is provided with a shaking and opening device, so that the entire in vitro quantitative detection instrument can automatically cover and shake, and does not need to perform shaking and removing the cap manually, thereby improving the degree of automation. Further, by setting a sample sampling device, a reagent box transport device, and a robot arm, automatic sample tube sampling, automatic reagent box transportation, automatic sample addition, and automatic detection are realized, and the degree of automation of the entire in vitro quantitative detection instrument is improved.
- FIG. 1 is a schematic structural diagram of a first perspective of an in vitro quantitative detection instrument provided by a first embodiment of the present application
- FIG. 2 is a schematic structural diagram of a second perspective of an in vitro quantitative detection instrument provided by the first embodiment of the present application;
- FIG. 3 is a schematic structural view of a first viewing angle of a shaking and opening device of an in vitro quantitative detection instrument provided by a first embodiment of the present application;
- FIG. 4 is a schematic structural view of a second perspective of the shake-and-uncover device of the in vitro quantitative detection instrument provided by the first embodiment of the present application;
- FIG. 5 is a schematic structural view of a third perspective of the shake-uncovering device of the in vitro quantitative detection instrument provided by the first embodiment of the present application;
- FIG. 6 is a schematic structural diagram of a cover-opening gripper of an in vitro quantitative detection instrument provided by the first embodiment of the present application;
- FIG. 7 is a schematic structural diagram of a kit delivery device of an in vitro quantitative detection instrument provided by the first embodiment of the present application.
- FIG. 8 is a schematic structural diagram of a kit delivery mechanism of an in vitro quantitative detection instrument provided by the first embodiment of the present application.
- FIG. 9 is a schematic structural diagram of a cartridge case of an in vitro quantitative detection instrument provided by the first embodiment of the present application.
- Icon 10-in vitro quantitative detection instrument; 100-sample sampling device; 101-sample aspiration area; 102-sample addition area; 110-drive section; 120-moving guide; 130-support plate; 140-scanning module; 200 -Shake lid opening device; 210- support; 211- first support plate; 212- second support plate; 220- cover opening mechanism; 221- cover opening jaws; 222- first drive assembly; 2211-inclined surface; 2212-chute; 2221-connecting part; 223-second driving assembly; 2231-driving part; 2232-synchronous belt assembly; 225-third driving assembly; 230-shaking mechanism; 231-clamping assembly; 2311-swing Pieces; 2312-first clamping portion; 2313-second clamping portion; 2314-connecting plate; 232- fourth driving component; 233- fifth driving component; 234- sixth driving component; 240- fixed test tube mechanism; 241-fixing piece; 242-driving piece; 300-reagent box
- orientations or positional relationships indicated by the terms “up” and “inner” are based on the orientations or positional relationships shown in the accompanying drawings, or the products used in this application are often used.
- the orientation or position relationship of the placement is only for the convenience of describing the application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, structure and operation in a specific orientation, so it cannot be understood as limit.
- This embodiment provides an in vitro quantitative detection device 10, which includes a sample sampling device 100, a shaker and lid opening device 200, a kit transport device 300, an incubation and detection component 400, and a robot arm. 500 and the housing 600.
- the in vitro quantitative detection device 10 is provided with a shake-and-uncover device 200 so that the entire in vitro quantitative-detection device 10 can be automatically opened and covered and shaken without manual shaking and uncovering, thereby increasing the degree of automation.
- the sample tube is automatically sampled, thereby realizing automatic transport of the reagent cartridge, automatic TIP sample addition, and automatic detection, thereby improving the entire in vitro quantitative detection instrument 10 Degree of automation.
- the kit transport device 300, the incubation and detection assembly 400, and the robot arm 500 are all disposed in the housing 600.
- the housing 600 has a first end 610 and an opposite second end 620; the sample sampling device 100 is disposed at the first end 610, the incubation and detection assembly 400 is disposed at the second end 620, and the robot arm 500 is disposed at the first Between one end 610 and the second end 620.
- the shaking and opening device 200 is disposed in the housing 600 and exposed to the first end 610, so as to cooperate with the sample sampling device 100 to open and shake the sample test tube.
- the robot arm 500 is disposed between the first end 610 and the second end 620 to facilitate operation between the sample sampling device 100, the incubation component, and the detection component.
- the robotic arm 500 is connected with a liquid suction needle group, and the robotic arm 500 can transport the liquid suction needle group to the sample sampling device 100, the reagent cartridge transfer device 300, and the incubation and detection component 400.
- the in vitro quantitative detection instrument 10 includes a sample injection device 100, a shaker opening device 200, a reagent cartridge conveying device 300, an incubation and detection module 400, and a robot arm 500. Each detection process has a reasonable layout, reliable operation, compact structure, and reduced the entire size. Volume of the in vitro quantitative detection device 10.
- incubation and detection component 400 described above may be selected from structures commonly used in the art and suitable for fluorescence detection.
- the sample injection device 100 is used for transporting a test tube rack in which a sample test tube is placed.
- the sample injection device 100 includes a driving part 110, a moving guide 120, and a plurality of supporting plates 130 for placing test tube racks; the driving part 110 is drivingly connected to the moving guide 120; each supporting plate 130 is connected to the moving guide 120 .
- the sample sampling device 100 further includes a code scanning component 140, which is disposed near the shaker and opening device 200; the code scanning component 140 is configured to scan the sample information in the test tube rack.
- the shake-opening and opening device 200 is disposed near the sample sampling device 100, and the shake-opening and opening device 200 is used for opening, shaking, and closing the sample test tube delivered by the sample injection device 100.
- the shake-uncovering device 200 includes a support portion 210, a lid-opening mechanism 220, a shaker mechanism 230, and a fixed test tube mechanism 240.
- the lid opening mechanism 220 is connected to one side of the support portion 210, and the shaker mechanism 230 is connected to the other side of the support portion 210 so that the lid opening and shaker operations do not interfere with each other and can be performed sequentially.
- the layout of the lid opening mechanism 220 and the shaker mechanism 230 is reasonable and compact, which further makes the volume of the entire in vitro quantitative detection apparatus 10 smaller and has the characteristics of miniaturization.
- the support portion 210 includes a first support plate 211 and a second support plate 212.
- the first support plate 211 and the second support plate 212 are oppositely disposed.
- the lid opening mechanism 220 is connected to one side of the first support plate 211
- the shaker mechanism 230 is connected to the other side of the first support plate 211, thereby separating the lid opening mechanism 220 and the shaker mechanism 230.
- the second support plate 212 is disposed on the side of the lid opening mechanism 220 away from the first support plate 211, which further increases the overall rigidity of the entire lid opening device 200, thereby ensuring smooth lid opening and smooth movement of the lid opening. Sex.
- the lid opening mechanism 220 includes a lid opening jaw 221, a first driving component 222, a second driving component 223, and a third driving component 225.
- the first driving component 222, the second driving component 223, and the third driving component 225 are all drivingly connected to the cover opening jaw 221.
- the first driving component 222 is used to drive the lid opening jaw 221 to clamp or release the sample test tube cover;
- the second driving component 223 is used to drive the lid opening jaw 221 to rotate;
- the third driving component 225 is used to drive the lid opening jaw 221 Up and down movement.
- the cap opening jaw 221 clamps the sample test tube cap and rotates at the same time, and the up and down movement realizes the operation of the mold person to unscrew the bottle cap, and then the sample test tube cap is opened or the sample test tube cap is capped.
- the lid opening jaw 221 includes at least three supporting jaws.
- the output shaft of the first driving component 222 is provided with at least three inclined surfaces 2211; the connecting ends of the at least three supporting claws are provided with inclined grooves 2212 that are matched and connected with the inclined surfaces 2211.
- the first driving component 222 moves, at least three supporting claws are driven to slide along the inclined surface 2211, so that the at least three supporting claws approach or move away from each other.
- a connecting portion 2221 is provided at an end portion of the output shaft of the first driving component 222, and at least three inclined surfaces 2211 are connected to the connecting portion 2221.
- the first driving component 222 is a linear motor.
- the three inclined surfaces 2211 are driven to slide in the foregoing three inclined grooves 2212, so that the three claws move away from each other or approach each other.
- the bottle cap needs to be opened, the three claws are close to each other and grasp the sample test tube.
- a plurality of friction portions are provided on an inner wall of each claw, so that the sample test tube can be firmly grasped.
- the second driving component 223 includes a driving portion 2231 and a timing belt component 2232; the driving portion 2231 is drivingly connected to the timing belt component 2232; and the timing belt component 2232 is drivingly connected to the cover opening jaw 221.
- the driving part 2231 is a motor
- the driving wheel of the timing belt assembly 2232 is connected to the motor
- the driven wheel is connected to the aforementioned connection part 2221
- the connection part 2221 is connected to the cover opening jaw 221.
- the connection portion 2221 is shared by the first driving component 222 and the second driving component 223, which greatly reduces the volume of the entire in vitro quantitative detection instrument 10.
- the third driving component 225 is a lead screw motor component.
- the lead screw motor component is drivingly connected to the lid opening jaw 221 to drive the lid opening jaw 221 to move up and down. When the lid opening jaw 221 rotates and cooperates with the up and down movement, it can ensure that the lid of the sample test tube is opened.
- the third driving component 225 to make the lid opening jaw 221 move up and down, the height of the lid opening jaw 221 can be adjusted, the space utilization rate is high, it is suitable for sample test tubes of different heights, and meets the testing and analysis equipment in the prior art
- the situation where high and low test tubes are used at the same time greatly increases the applicable range of the entire in vitro quantitative detection instrument 10 and effectively solves the problem of the matching of samples and test tubes in the prior art.
- the shaker mechanism 230 includes a clamping component 231, a fourth driving component 232, a fifth driving component 233, and a sixth driving component 234.
- the fourth driving component 232, the fifth driving component 233, and the sixth driving component 234 are all drivingly connected to the clamping component 231.
- the fourth driving component 232 is used to drive the clamping component 231 to rotate to drive the sample test tube to shake.
- the fifth driving component 233 is configured to drive the clamping component 231 toward or away from the fourth driving component 232.
- the sixth driving component 234 is used for driving the clamping component 231 to move up and down.
- the sample test tube is clamped by the clamping component 231, and the fourth driving component 232 rotates the clamping component 231, so that the sample test tube can be shaken from side to side.
- the movement of the sixth driving component 234 can also realize that the sample test tube is shaken up and down. By shaking in all directions, the test solution in the sample test tube is evenly shaken.
- the clamping assembly 231 includes a swinging member 2311, a first clamping portion 2312 and a second clamping portion 2313.
- the swinging member 2311 is connected to the first clamping portion 2312; the second clamping portion 2313 is connected to the fifth driving component 233; the first clamping portion 2312 and the second clamping portion 2313 are oppositely disposed.
- the swinging member 2311 is located at an end of the first clamping portion 2312 away from the second clamping portion 2313. When the sample test tube is clamped between the first clamping portion 2312 and the second clamping portion 2313, the swinging member 2311 functions as a weight Role, with the sample test tube swing.
- clamping component 231 is fixedly connected to the fourth driving component 232, and when the fourth driving component 232 moves, the clamping component 231 is driven to move, so that the second clamping portion 2313 is clamped near or away from the first clamping portion 2312. Or loosen the sample tube.
- the fifth driving component 233 is a motor
- the second clamping portion 2313 is drivingly connected to the motor.
- the fourth driving component 232 includes a belt transmission component and a motor.
- the first clamping portion 2312 is driven toward or away from the second clamping portion 2313 by the transmission of the belt transmission component.
- the belt transmission component of the fourth driving component 232 is disposed above the clamping component 231 and is connected to the clamping component 231 through a connecting plate 2314.
- One end of the connecting plate 2314 is fixedly connected to the belt.
- the first holding portion 2312 and the swinging member 2311 of the clamping assembly 231 are installed at the other end of the connecting plate 2314.
- the sixth driving component 234 is a linear motor, and the clamping component 231 is connected to the linear motor through the connection plate 2314 described above.
- the linear motor moves up and down, it can drive the clamping assembly 231 to move up and down, and can further shake the sample test tube up and down, further improving the effect of sample shaking.
- the fixed test tube mechanism 240 includes a fixing member 241 and a driving member 242; the fixing member 241 is used to fix the sample test tube; the driving member 242 is used to drive the fixing member 241 to run straight under the lid opening jaw 221 to cooperate with the lid opening jaw 221 Open the lid of the sample tube.
- the fixing member 241 includes two fixing brackets disposed opposite to each other, and the sample test tube can be fixed between the two fixing brackets. Further optionally, both of the fixing brackets are made of a flexible material, so that not only the sample test tube can be well fixed, but the sample test tube will not be damaged.
- the reagent cartridge transporting device 300 includes a plurality of reagent cartridge storage assemblies 310 and a reagent cartridge transport mechanism 320.
- the reagent cartridge storage assembly 310 includes a plurality of accommodating chambers 311 for storing reagent kits, and a cartridge case 312; each cartridge 311 houses a cartridge case 312; and a plurality of reagent cartridges 313 Stacked inside the magazine housing 312.
- the kit transport mechanism 320 includes a gripping component 321, a moving rail 322, and a driving component 323.
- the gripping component 321 is used to grip the reagent cartridge 313 out of the cartridge housing 312; the gripping component 321 is drivingly connected to the driving component 323 to drive the gripping component 321 to move along the moving track 322.
- the test tube rack is automatically sent to the scanning area in the sample injection device 100 to scan the code through the scanning module 140, and then sent to the shaker and opening device 200 to shake it.
- the rack is sent to the sample introduction device 100 and shaken to the lid opening device 200 for lid opening.
- the robot arm 500 automatically extracts the TIP head, and automatically draws the diluent according to need and adds it to the mixing area of the incubation and detection module 400. After cleaning the TIP head, move to the aspiration area 101. After that, the sample is sent to the sample application area 102 by the sample injection device 100 and sucked by the robot arm 500.
- the operator manually places the reagent cartridge magazine in the reagent cartridge storage assembly 310 of the reagent cartridge transporting device 300.
- the reagent cartridge transport mechanism 320 After detecting the cartridge, the reagent cartridge transport mechanism 320 automatically removes the required reagent cartridge as needed and waits in the sample application area 102.
- the robot arm 500 is charged.
- the loaded reagent strip is sent from the sample loading area 102 to the incubation area of the incubation and detection module 400 by the reagent cartridge transport mechanism 320.
- the incubation time is detected by the kit transport mechanism 320 from the incubation area to the detection area of the incubation and detection assembly 400.
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Abstract
本申请涉及外定量检测领域，具体而言，涉及一种体外定量检测仪器。该仪器包括样本进样装置、摇匀开盖装置、试剂盒运送装置、温育、检测组件以及机械臂。摇匀开盖装置靠近样本进样装置设置，摇匀开盖装置用于对样本进样装置运送来的样本试管进行开盖摇匀关盖。试剂盒运送装置包括多个试剂盒存储组件以及试剂盒输送机构。机械臂连接有吸液针组，机械臂能够将吸液针组运送至样本进样装置、试剂盒运送装置以及温育、检测组件。通过设置摇匀开盖装置使得整个体外定量检测仪器能够自动开盖覆盖以及摇匀，不需要人工进行摇匀拔盖，提高了自动化程度。通过设置样本进样装置、试剂盒运送装置以及机械臂使得样本试管自动进样、加样、检测。
Description
本申请涉及外定量检测领域，具体而言，涉及一种体外定量检测仪器。
体外定量检测仪器能够定量检测人血清，血浆，全血或尿液。用于临床辅助诊断。
现有技术中的体外定量检测仪器试管不带摇匀开盖需要人工摇匀拔盖，机器尺寸偏大重量过重。
发明内容
本申请的目的在于提供一种体外定量检测仪器，不需要人工对试管进行开盖摇匀覆盖，自动化程度高。
为了实现上述目的，本申请实施例采用的技术方案如下：
一种体外定量检测仪器，包括：样本进样装置，样本进样装置用于输送放置样本试管的试管架；摇匀开盖装置，摇匀开盖装置靠近样本进样装置设置，摇匀开盖装置用于对样本进样装置运送来的样本试管进行开盖摇匀关盖；试剂盒运送装置，试剂盒运送装置包括多个试剂盒存储组件以及试剂盒输送机构；温育、检测组件；以及机械臂，机械臂连接有吸液针组，机械臂能够将吸液针组运送至样本进样装置、试剂盒运送装置以及温育、检测组件。
在本申请较佳的实施例中，摇匀开盖装置包括：支撑部；开盖机构，开盖机构连接于支撑部的一侧；开盖机构包括开盖夹爪、第一驱动组件、第二驱动组件以及第三驱动组件；第一驱动组件、第二驱动组件以及第三驱动组件均传动连接于开盖夹爪；第一驱动组件用于驱动开盖夹爪夹紧或者松开样本试管盖；第二驱动组件用于驱动开盖夹爪转动；第三驱动组件用于驱动开盖夹爪相对支撑部上下运动；摇匀机构，摇匀机构连接于支撑部的另一侧；摇匀机构包括夹持组件、第四驱动组件、第五驱动组件以及第六驱动组件；第四驱动组件、第五驱动组件以及第六驱动组件均传动连接于夹持组件；夹持组件用于夹持样本试管；第四驱动组件用于驱动夹持组件转动以带动样本试管摇晃；第五驱动组件用于驱动夹持组件靠近或者远离第四驱动组件；第六驱动 组件用于驱动夹持组件上下运动；以及固定试管机构，固定试管机构设置在开盖夹爪下方，用于固定样本试管以配合开盖夹爪开盖。
在本申请较佳的实施例中，开盖夹爪包括至少三个支爪；第一驱动组件的输出轴连接有至少三个斜面；至少三个支爪的连接端均设置有与斜面匹配连接的斜槽；当第一驱动组件运动时，带动至少三个支爪沿斜面滑动，以使至少三个支爪相互靠近或者远离。
在本申请较佳的实施例中，夹持组件包括摇摆件、第一夹持部和第二夹持部；摇摆件连接于第一夹持部；第二夹持部传动连接于第五驱动组件；第一夹持部和第二夹持部相对设置。
在本申请较佳的实施例中，第一夹持部固定连接于第四驱动组件，当第四驱动组件运动时带动第一夹持部运动，以使第一夹持部靠近或者远离第二夹持部。
在本申请较佳的实施例中，试剂盒存储组件包括多个用于存放试剂盒的容置腔以及弹夹壳体；每一个容置腔内均放置有一个弹夹壳体；多个试剂盒叠放在弹夹壳体内。
在本申请较佳的实施例中，试剂盒输送机构包括夹取组件、移动轨道以及驱动组件；夹取组件用于将试剂盒从弹夹壳体内夹取出；夹取组件传动连接于驱动组件，以带动夹取组件沿移动轨道移动。
在本申请较佳的实施例中，样本进样装置包括驱动部、移动导轨以及多个用于放置试管架的支撑板；驱动部传动连接于移动导轨；每一个支撑板均连接于移动导轨。
在本申请较佳的实施例中，样本进样装置还包括扫码组件，扫码组件靠近摇匀开盖装置设置；扫码组件用于对试管架内的样本信息进行扫码。
在本申请较佳的实施例中，体外定量检测仪器还包括壳体，壳体具有第一端和相对的第二端；样本进样装置设置在第一端，温育组件和检测组件设置在第二端，机械臂设置在第一端和第二端之间。
本申请的有益效果是：
本申请提供的一种体外定量检测仪器，包括：样本进样装置、摇匀开盖装置、试剂盒运送装置、温育、检测组件以及机械臂。其中，样本进样装置用于输送放置样本试管的试管架。摇匀开盖装置靠近样本进样装置设置，摇匀开盖装置用于对样本进样装置运送来的样本试管进行开盖摇匀关盖。试剂盒运送装置包括多个试剂盒存储组件以及试剂盒输送机构。机械臂连接有吸液针组，机械臂能够将吸液针组运送至样本进 样装置、试剂盒运送装置以及温育、检测组件。该体外定量检测仪器通过设置摇匀开盖装置使得整个体外定量检测仪器能够自动开盖覆盖以及摇匀，不需要人工进行摇匀拔盖，提高了自动化程度。进一步地，通过设置样本进样装置、试剂盒运送装置以及机械臂，实现了样本试管自动进样、试剂盒自动运输、自动加样、自动检测，提高了整个体外定量检测仪器的自动化程度。
为了更清楚地说明本申请实施例的技术方案，下面将对实施例中所需要使用的附图作简单地介绍，应当理解，以下附图仅示出了本申请的某些实施例，因此不应被看作是对范围的限定，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他相关的附图。
图1为本申请第一实施例提供的体外定量检测仪器的第一视角的结构示意图；
图2为本申请第一实施例提供的体外定量检测仪器的第二视角的结构示意图；
图3为本申请第一实施例提供的体外定量检测仪器的摇匀开盖装置的第一视角的结构示意图；
图4为本申请第一实施例提供的体外定量检测仪器的摇匀开盖装置的第二视角的结构示意图；
图5为本申请第一实施例提供的体外定量检测仪器的摇匀开盖装置的第三视角的结构示意图；
图6为本申请第一实施例提供的体外定量检测仪器的开盖夹爪的结构示意图；
图7为本申请第一实施例提供的体外定量检测仪器的试剂盒运送装置的结构示意图；
图8为本申请第一实施例提供的体外定量检测仪器的试剂盒输送机构的结构示意图；
图9为本申请第一实施例提供的体外定量检测仪器的弹夹壳体的结构示意图。
图标：10-体外定量检测仪器；100-样本进样装置；101-吸样区；102-加样区；110-驱动部；120-移动导轨；130-支撑板；140-扫码组件；200-摇匀开盖装置；210-支撑部；211-第一支撑板；212-第二支撑板；220-开盖机构；221-开盖夹爪；222-第一驱 动组件；2211-斜面；2212-斜槽；2221-连接部；223-第二驱动组件；2231-驱动部；2232-同步带组件；225-第三驱动组件；230-摇匀机构；231-夹持组件；2311-摇摆件；2312-第一夹持部；2313-第二夹持部；2314-连接板；232-第四驱动组件；233-第五驱动组件；234-第六驱动组件；240-固定试管机构；241-固定件；242-驱动件；300-试剂盒运送装置；310-试剂盒存储组件；311-容置腔；312-弹夹壳体；313-试剂盒；320-试剂盒输送机构；321-夹取组件；322-移动轨道；323-驱动组件；400-温育、检测组件；500-机械臂；600-壳体；610-第一端；620-第二端。
为使本申请实施例的目的、技术方案和优点更加清楚，下面将结合本申请实施例中的附图，对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本申请一部分实施例，而不是全部的实施例。通常在此处附图中描述和示出的本申请实施例的组件可以以各种不同的配置来布置和设计。
因此，以下对在附图中提供的本申请的实施例的详细描述并非旨在限制要求保护的本申请的范围，而是仅仅表示本申请的选定实施例。基于本申请中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本申请保护的范围。
应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步定义和解释。
在本申请实施例的描述中，需要说明的是，术语“上”、“内”等指示的方位或位置关系为基于附图所示的方位或位置关系，或者是该申请产品使用时惯常摆放的方位或位置关系，仅是为了便于描述本申请和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请的限制。
在本申请的描述中，还需要说明的是，除非另有明确的规定和限定，术语“设置”、“安装”、“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本申请中的具体含义。
第一实施例
请参照图1-图9，本实施例提供一种体外定量检测仪器10，其包括样本进样装置 100、摇匀开盖装置200、试剂盒运送装置300、温育、检测组件400、机械臂500以及壳体600。该体外定量检测仪器10通过设置摇匀开盖装置200使得整个体外定量检测仪器10能够自动开盖覆盖以及摇匀，不需要人工进行摇匀拔盖，提高了自动化程度。进一步地，通过设置样本进样装置100、试剂盒运送装置300以及机械臂500使得样本试管自动进样，实现了试剂盒自动运输，自动TIP加样，自动检测，提高了整个体外定量检测仪器10的自动化程度。
进一步地，试剂盒运送装置300、温育、检测组件400以及机械臂500均设置在壳体600内。进一步地，壳体600具有第一端610和相对的第二端620；样本进样装置100设置在第一端610，温育、检测组件400设置在第二端620，机械臂500设置在第一端610和第二端620之间。进一步地，摇匀开盖装置200设置在壳体600内露出至第一端610处，从而与样本进样装置100相互配合，对样本试管进行开盖摇匀关盖。进一步地，机械臂500设置在第一端610和第二端620之间，方便在样本进样装置100、温育组件以及检测组件之间运行。具体地，机械臂500连接有吸液针组，机械臂500能够将吸液针组运送至样本进样装置100、试剂盒运送装置300以及温育、检测组件400。该体外定量检测仪器10样本进样装置100、摇匀开盖装置200、试剂盒运送装置300、温育、检测组件400以及机械臂500各个检测流程布局合理，运行可靠，结构紧凑，缩小了整个体外定量检测仪器10的体积。
需要说明的是，上述的温育、检测组件400可以选择本领域常见的适于荧光检测的结构。
进一步地，样本进样装置100用于输送放置样本试管的试管架。具体地，样本进样装置100包括驱动部110、移动导轨120以及多个用于放置试管架的支撑板130；驱动部110传动连接于移动导轨120；每一个支撑板130均连接于移动导轨120。
进一步地，样本进样装置100还包括扫码组件140，扫码组件140靠近摇匀开盖装置200设置；扫码组件140用于对试管架内的样本信息进行扫码。
进一步地，摇匀开盖装置200靠近样本进样装置100设置，摇匀开盖装置200用于对样本进样装置100运送来的样本试管进行开盖摇匀关盖。
具体地，摇匀开盖装置200包括支撑部210、开盖机构220、摇匀机构230以及固定试管机构240。
进一步地，开盖机构220连接于支撑部210的一侧，摇匀机构230连接于支撑部 210的另一侧从而使得开盖和摇匀操作不会相互干扰，能够依次进行。开盖机构220和摇匀机构230布局合理紧凑，进一步使得整个体外定量检测仪器10的体积较小，具有小型化的特点。
进一步地，支撑部210包括第一支撑板211和第二支撑板212。第一支撑板211和第二支撑板212相对设置。开盖机构220连接于第一支撑板211的一侧，摇匀机构230连接于第一支撑板211的另一侧，从而将开盖机构220和摇匀机构230分隔开。进一步地，第二支撑板212设置在开盖机构220远离第一支撑板211的一侧，进一步地增加了整个摇匀开盖装置200的整体刚性，进而能够保证摇匀、开盖运动的平稳性。
进一步地，开盖机构220包括开盖夹爪221、第一驱动组件222、第二驱动组件223以及第三驱动组件225。第一驱动组件222、第二驱动组件223以及第三驱动组件225均传动连接于开盖夹爪221。第一驱动组件222用于驱动开盖夹爪221夹紧或者松开样本试管盖；第二驱动组件223用于驱动开盖夹爪221转动；第三驱动组件225用于驱动开盖夹爪221上下运动。从而使得开盖夹爪221夹紧样本试管盖同时转动，并且上下运动即实现模人手拧开瓶盖的动作，进而将样本试管盖打开或者为样本试管盖上盖子。
进一步地，开盖夹爪221包括至少三个支爪。第一驱动组件222的输出轴设置有至少三个斜面2211；至少三个支爪的连接端均设置有与斜面2211匹配连接的斜槽2212。当第一驱动组件222运动时，带动至少三个支爪沿斜面2211滑动，以使至少三个支爪相互靠近或者远离。
具体地，在第一驱动组件222的输出轴的端部设置有连接部2221，至少三个斜面2211连接于连接部2221。在本实施例中，第一驱动组件222为直线电机，当直线电机运动时，带动三个斜面2211在前述的三个斜槽2212内滑动，进而使得三个支爪相互远离或者相互靠近。当需要打开瓶盖时，三个支爪相互靠近，抓紧样本试管。进一步地，每一个支爪的内壁上均设置有多个摩擦部，进而能够稳固地抓紧样本试管。
进一步地，第二驱动组件223包括驱动部2231和同步带组件2232；驱动部2231传动连接于同步带组件2232；同步带组件2232传动连接于开盖夹爪221。在本实施例中，驱动部2231为电机，同步带组件2232的主动轮连接于电机，从动轮连接于前述连接部2221，连接部2221连接于开盖夹爪221，进而当电机转动时，能够带动开盖夹爪221转动。进一步地，由于同步带组件2232连接于连接部2221，使得连接部2221为第一驱动组件222和第二驱动组件223共用，极大地减小了整个体外定量检 测仪器10的体积。
进一步地，第三驱动组件225为丝杠电机组件。丝杠电机组件传动连接于开盖夹爪221，以驱动开盖夹爪221上下运动。当开盖夹爪221转动时同时配合上下运动，能够保证将样本试管的盖子打开。进一步地，通过设置第三驱动组件225使得开盖夹爪221上下运动，能够调整开盖夹爪221的高度，空间利用率高，适用于不同高度的样本试管，满足现有技术中检测分析设备需要高、低试管同时使用的情况，极大地增大了整个体外定量检测仪器10的适用范围，有效解决了现有技术中样本与试管搭配问题。
进一步地，摇匀机构230包括夹持组件231、第四驱动组件232、第五驱动组件233以及第六驱动组件234。第四驱动组件232、第五驱动组件233以及第六驱动组件234均传动连接于夹持组件231。第四驱动组件232用于驱动夹持组件231转动以带动样本试管摇晃。第五驱动组件233用于驱动夹持组件231靠近或者远离第四驱动组件232。第六驱动组件234用于驱动夹持组件231上下运动。通过夹持组件231夹紧样本试管，第四驱动组件232转动夹持组件231，进而使得样本试管实现左右摇晃。第六驱动组件234的运动，还可以实现样本试管上下摇晃，通过全方位的摇晃，进而保证将样本试管内的试液摇匀。
进一步地，夹持组件231包括摇摆件2311、第一夹持部2312和第二夹持部2313。摇摆件2311连接于第一夹持部2312；第二夹持部2313连接于第五驱动组件233；第一夹持部2312和第二夹持部2313相对设置。摇摆件2311位于第一夹持部2312远离第二夹持部2313的一端，当第一夹持部2312和第二夹持部2313之间夹紧样本试管时，摇摆件2311起到配重的作用，配合样本试管摇摆。
进一步地，夹持组件231固定连接于第四驱动组件232，当第四驱动组件232运动时带动夹持组件231运动，以使第二夹持部2313靠近或者远离第一夹持部2312夹紧或者松开样本试管。
进一步地，在本实施例中，第五驱动组件233为电机，第二夹持部2313传动连接于电机，当电机转动时，能够带动第二夹持部2313转动。第四驱动组件232包括带传动组件和电机，当电机转动时，通过带传动组件的传动，带动第一夹持部2312靠近或者远离第二夹持部2313。
具体地，第四驱动组件232的带传动组件设置在夹持组件231的上方，通过连接板2314连接于夹持组件231。连接板2314的一端固定连接于皮带，夹持组件231的 第一夹持部2312以及摇摆件2311安装在连接板2314的另一端，进而当电机带动皮带运动时，第一夹持部2312以及摇摆件2311向靠近或者远离第二夹持部2313的方向运动。
进一步地，第六驱动组件234为直线电机，夹持组件231通过上述的连接板2314连接于直线电机。当直线电机上下运动时，能够带动夹持组件231上下运动，进而能够实现对样本试管的上下摇晃，进一步地提高样本摇匀的效果。
进一步地，固定试管机构240包括固定件241以及驱动件242；固定件241用于固定样本试管；驱动件242用于驱动固定件241在开盖夹爪221下方直线运行，以配合开盖夹爪221打开样本试管的盖子。具体地，在本实施例中，固定件241包括两个相对设置的固定支件，样本试管能够被固定在这两个固定支件之间。进一步可选的，这两个固定支件均选择由柔性材料制成，进而不仅能够很好地固定住样本试管，而且不会损坏样本试管。
进一步地，试剂盒运送装置300包括多个试剂盒存储组件310以及试剂盒输送机构320。进一步地，试剂盒存储组件310包括多个用于存放试剂盒的容置腔311以及弹夹壳体312；每一个容置腔311内均放置有一个弹夹壳体312；多个试剂盒313叠放在弹夹壳体312内。试剂盒输送机构320包括夹取组件321、移动轨道322以及驱动组件323。夹取组件321用于将试剂盒313从弹夹壳体312内夹取出；夹取组件321传动连接于驱动组件323，以带动夹取组件321沿移动轨道322移动。
使用时，试管架在样本进样装置100里被自动送到扫码区通过扫码组件140扫码，然后被送至摇匀开盖装置200摇匀，摇匀完成后放回试管架，试管架被样本进样装置100送至摇匀开盖装置200进行开盖。机械臂500会自动提取TIP头，自动根据需要吸取稀释液加至温育、检测组件400的混匀区。清洁TIP头后移动至吸样区101。之后再由样本进样装置100将样本送至加样区102由机械臂500进行吸样。由操作人员手工在试剂盒运送装置300的试剂盒存储组件310放入试剂条弹夹，试剂盒输送机构320在检测到弹夹之后会根据需要自动取出需要的试剂条并在加样区102等待机械臂500加样。加样完的试剂条由试剂盒输送机构320从加样区102送至温育、检测组件400的温育区。温育时间到了由试剂盒输送机构320从温育区送至温育、检测组件400的检测区检测。
以上所述仅为本申请的优选实施例而已，并不用于限制本申请，对于本领域的技术人员来说，本申请可以有各种更改和变化。凡在本申请的精神和原则之内，所作的 任何修改、等同替换、改进等，均应包含在本申请的保护范围之内。应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步定义和解释。
Claims (10)
- 一种体外定量检测仪器，其特征在于，包括：样本进样装置，所述样本进样装置用于输送放置样本试管的试管架；摇匀开盖装置，所述摇匀开盖装置靠近所述样本进样装置设置，所述摇匀开盖装置用于对所述样本进样装置运送来的所述样本试管进行开盖摇匀关盖；试剂盒运送装置，所述试剂盒运送装置包括多个试剂盒存储组件以及试剂盒输送机构；温育、检测组件；以及机械臂，所述机械臂连接有吸液针组，所述机械臂能够将所述吸液针组运送至所述样本进样装置、所述试剂盒运送装置以及所述温育、检测组件。
- 如权利要求1所述的体外定量检测仪器，其特征在于，所述摇匀开盖装置包括：支撑部；开盖机构，所述开盖机构连接于所述支撑部的一侧；所述开盖机构包括开盖夹爪、第一驱动组件、第二驱动组件以及第三驱动组件；所述第一驱动组件、所述第二驱动组件以及所述第三驱动组件均传动连接于所述开盖夹爪；所述第一驱动组件用于驱动所述开盖夹爪夹紧或者松开样本试管盖；所述第二驱动组件用于驱动所述开盖夹爪转动；所述第三驱动组件用于驱动所述开盖夹爪相对所述支撑部上下运动；摇匀机构，所述摇匀机构连接于所述支撑部的另一侧；所述摇匀机构包括夹持组件、第四驱动组件、第五驱动组件以及第六驱动组件；所述第四驱动组件、所述第五驱动组件以及所述第六驱动组件均传动连接于所述夹持组件；所述夹持组件用于夹持所述样本试管；所述第四驱动组件用于驱动所述夹持组件转动以带动所述样本试管摇晃；所述第五驱动组件用于驱动所述夹持组件靠近或者远离所述第四驱动组件；所述第六驱动组件用于驱动所述夹持组件上下运动；以及固定试管机构，所述固定试管机构设置在所述开盖夹爪下方，用于固定所述样本试管以配合所述开盖夹爪开盖。
- 如权利要求2所述的体外定量检测仪器，其特征在于，所述开盖夹爪包括至少三个支爪；所述第一驱动组件的输出轴连接有至少三个斜面；至少三个所述 支爪的连接端均设置有与所述斜面匹配连接的斜槽；当所述第一驱动组件运动时，带动至少三个所述支爪沿所述斜面滑动，以使至少三个所述支爪相互靠近或者远离。
- 如权利要求2所述的体外定量检测仪器，其特征在于，所述夹持组件包括摇摆件、第一夹持部和第二夹持部；所述摇摆件连接于所述第一夹持部；所述第二夹持部传动连接于所述第五驱动组件；所述第一夹持部和所述第二夹持部相对设置。
- 如权利要求4所述的体外定量检测仪器，其特征在于，所述第一夹持部固定连接于第四驱动组件，当所述第四驱动组件运动时带动所述第一夹持部运动，以使所述第一夹持部靠近或者远离所述第二夹持部。
- 如权利要求1所述的体外定量检测仪器，其特征在于，所述试剂盒存储组件包括多个用于存放试剂盒的容置腔以及弹夹壳体；每一个所述容置腔内均放置有一个所述弹夹壳体；多个所述试剂盒叠放在所述弹夹壳体内。
- 如权利要求6所述的体外定量检测仪器，其特征在于，所述试剂盒输送机构包括夹取组件、移动轨道以及驱动组件；所述夹取组件用于将所述试剂盒从所述弹夹壳体内夹取出；所述夹取组件传动连接于所述驱动组件，以带动所述夹取组件沿所述移动轨道移动。
- 如权利要求1所述的体外定量检测仪器，其特征在于，所述样本进样装置包括驱动部、移动导轨以及多个用于放置试管架的支撑板；所述驱动部传动连接于所述移动导轨；每一个所述支撑板均连接于所述移动导轨。
- 如权利要求8所述的体外定量检测仪器，其特征在于，所述样本进样装置还包括扫码组件，所述扫码组件靠近所述摇匀开盖装置设置；所述扫码组件用于对所述试管架内的样本信息进行扫码。
- 如权利要求1-9任一项所述的体外定量检测仪器，其特征在于，所述体外定量检测仪器还包括壳体，所述壳体具有第一端和相对的第二端；所述样本进样 装置设置在所述第一端，所述温育组件和所述检测组件设置在所述第二端，所述机械臂设置在所述第一端和所述第二端之间。
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| CN109580923A (zh) * | 2018-12-24 | 2019-04-05 | 徐建顺 | 一种血栓检测机 |
| CN109939758A (zh) * | 2019-03-28 | 2019-06-28 | 上海市嘉定区中心医院 | 一种血液流变检测用的自动血液前处理及移液平台 |
| CN112147106A (zh) * | 2019-06-27 | 2020-12-29 | 深圳市帝迈生物技术有限公司 | 微流控样本分析装置及其进样机构 |
| CN110794158A (zh) * | 2019-09-27 | 2020-02-14 | 广州万孚生物技术股份有限公司 | 体外诊断分析仪、自动取样装置及自动取样方法 |
| CN113122436A (zh) * | 2021-03-29 | 2021-07-16 | 中标华谱(山东)智能科技有限公司 | 一种食品微生物测试用的培养皿制作装置及方法 |
| CN113252650B (zh) * | 2021-04-13 | 2024-03-15 | 珠海迪尔生物工程股份有限公司 | B群工作站 |
| CN114047346A (zh) * | 2022-01-11 | 2022-02-15 | 南京万承生物科技有限公司 | 一种体液样本体外自动化检测系统的前处理模块 |
| CN115639368B (zh) * | 2022-10-25 | 2024-04-26 | 南京帝基生物科技有限公司 | 呼吸道病毒的快速检测试剂盒及制备方法 |
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