WO2020017760A1 - 각질 박리 증진용 화장료 조성물 - Google Patents

각질 박리 증진용 화장료 조성물 Download PDF

Info

Publication number
WO2020017760A1
WO2020017760A1 PCT/KR2019/006806 KR2019006806W WO2020017760A1 WO 2020017760 A1 WO2020017760 A1 WO 2020017760A1 KR 2019006806 W KR2019006806 W KR 2019006806W WO 2020017760 A1 WO2020017760 A1 WO 2020017760A1
Authority
WO
WIPO (PCT)
Prior art keywords
exfoliation
weight
keratin
glycerin
serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2019/006806
Other languages
English (en)
French (fr)
Korean (ko)
Inventor
안병준
강내규
김진현
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG H&H Co Ltd
Original Assignee
LG Household and Health Care Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020190063704A external-priority patent/KR102253135B1/ko
Application filed by LG Household and Health Care Ltd filed Critical LG Household and Health Care Ltd
Priority to CN202411370951.8A priority Critical patent/CN119157765A/zh
Priority to US17/260,724 priority patent/US20210267865A1/en
Priority to EP19838725.0A priority patent/EP3824872B1/en
Priority to JP2021502856A priority patent/JP7558606B2/ja
Priority to CN201980047555.2A priority patent/CN112423730B/zh
Publication of WO2020017760A1 publication Critical patent/WO2020017760A1/ko
Anticipated expiration legal-status Critical
Priority to JP2024071804A priority patent/JP7726595B2/ja
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients

Definitions

  • the present invention relates to a cosmetic composition for enhancing skin exfoliation.
  • the stratum corneum is the outermost layer of the skin and consists of a lipid layer of lamellae structure containing keratinocytes and ceramides.
  • the stratum corneum has a protective effect from external substances and at the same time functions as a protective film that prevents water escape into the interior. Done.
  • the normal stratum corneum has a thickness of about 15-20 layers, and the decomposition of the coniode mossom proceeds due to the action of the serine protease that is activated outside the stratum corneum, and eventually undergoes a complete detachment from the skin. This process takes about 15-20 days for normal cells. Even without genetic diseases such as ichthyosis, aging, dryness, acne skin, etc., the stratum corneum is thickened longer than normal, the stratum corneum is thickening, the stratum corneum is thickening.
  • keratin stratification is generally caused by factors such as decreased skin moisturizing power, decreased expression or activity of serine protease, ultraviolet rays, and decreased cellular activity.
  • methods such as keratin exfoliation through physical scrub preparations, exfoliation by chemical preparations, and physiological cell activity increase are generally used.
  • This method of keratin exfoliation artificially removes external keratinocytes and replaces the outermost stratum corneum with new keratinocytes from the inside to solve keratin stratification and solve external problems such as skin stiffness and dullness. There is this.
  • Resolving keratin stratification by enhancing keratin exfoliation also has additional effects such as fine wrinkles removal, blemishes, rough skin improvement, etc., and is being used in various products.
  • alpha hydroxy acid (AHA), beta Beta hydroxy acid (BHA) or poly hydroxy acid (PHA) is typically used.
  • AHA, BHA, and PHA is inserted into the stratum corneum to release hydrogen ions, weakening the corniodesmosome bond, leading to delamination. Because of the high, inevitably low pH is required. Therefore, low pH causes skin side effects such as itching, itching, and erythema, and research is being conducted to overcome such side effects.
  • the present inventors have identified a composition including serine and carnitine that exhibits efficacy over AHA in the same concentration in neutral or weakly acidic conditions according to the prior application patent 10-2017-0165268 according to a previous study, and the stimulation is relatively low It was also confirmed that no appearance was provided as an excellent novel keratin peeling material.
  • the problem to be solved by the present invention is to select the composition of the cosmetic so that the accessibility of the exfoliating agent to the keratin binding protein, so that the added exfoliation promoting effect can be fully exhibited, there is no irritation to the cosmetic It is to provide cosmetics.
  • the problem to be solved by the present invention is to solve the problem that the keratin exfoliation efficacy is reduced when the serine or carnitine, which has an effect that is superior to the efficacy of the existing keratin exfoliation efficacy raw material at the weak acid-neutral pH, actually applied to cosmetic formulation.
  • the problem to be solved by the present invention is to provide a cosmetic composition for enhancing keratin exfoliation, including serine or carnitine, but substantially no moisturizer component having a polyol group or at a certain concentration or less.
  • the present invention provides a cosmetic composition for enhancing keratin exfoliation, including a keratin exfoliant, does not include a polyol moisturizer or 10% by weight or less based on the total weight of the composition.
  • the exfoliating agent of the cosmetic composition for promoting exfoliation of the present invention is any one or more of serine and carnitine.
  • the polyol moisturizing agent of the cosmetic composition for promoting exfoliation of the invention glycerin (Glycerine), dipropylene glycol (Dipropylene glycol), butylene glycol (Butylene glycol), glycerin-26 ( One or more selected from the group consisting of Glycereth-26), methylgluceth-20, and pentyleneglycol.
  • the exfoliating agent of the cosmetic composition for enhancing exfoliation of the present invention is included in 0.001 to 20% by weight relative to the total composition weight.
  • the polyol humectant of the cosmetic composition for enhancing keratin exfoliation of the present invention is not included or is included in an amount of 10% by weight or less based on the total composition weight.
  • the cosmetic composition for enhancing exfoliation of the invention is pH 5 to 8.
  • the accessibility of the exfoliating agent to the exfoliating protein is maintained so that the exfoliation promoting effect can be fully exhibited.
  • the cosmetic composition for exfoliation including serine or carnitine, which gives a keratin exfoliation effect that is superior to the efficacy of the conventional efficacy ingredient at low acidity-neutral pH without stimulation, the exfoliation effect of serine or carnitine is maintained without being reduced. It is effective.
  • 1 is a result of evaluation of skin exfoliation of porcine skin according to the combination of 5% serine and glycerin.
  • Figure 2 is a result of evaluation of skin peeling of porcine skin according to the combination of carnitine 5% and glycerin.
  • 3 is a result of evaluation of skin exfoliation of porcine skin according to a combination of serine, glycerin, dipropylene glycol, and 1,3-butylene glycol.
  • Figure 4 is a result of evaluation of skin exfoliation of porcine skin according to the combination consisting of more varied concentration of DPG in a serine 5% solution.
  • 5 is a result of evaluation of skin exfoliation of porcine skin according to a combination of carnitine and glycerin, dipropylene glycol, and 1,3-butylene glycol.
  • Figure 8 shows the result of measuring the relative comparison of the keratin exfoliation ability in the combination of carnitine (5%) and glycerin.
  • Figure 9 shows the result of measuring the relative comparison value of keratin exfoliation ability in the combination of serine (5%) and glycerin.
  • Figure 10 shows the result of measuring the relative comparison value of keratin exfoliation ability in the combination of carnitine (0.5%) and glycerin.
  • Figure 11 shows the result of measuring the relative comparison value of keratin exfoliation ability in the combination of serine (0.5%) and glycerin.
  • Figure 13 shows the result of TT100% measurement by the combination of serine and glycerin.
  • the present invention for achieving the above-described object, and provides a cosmetic composition for enhancing keratin exfoliation, including a keratin exfoliant, a polyol moisturizing agent or no more than 10% by weight relative to the total composition weight.
  • the present inventors have attempted to produce a commercially available cosmetics that impart keratin exfoliation enhancement function by including a keratin exfoliant in a cosmetic composition including various additives such as surfactant, perfume, preservative, moisturizer, thickener, antioxidant, etc. While confirming that there is a problem that the efficiency is significantly lowered than the expected ability to enhance the exfoliation according to the concentration, while studying this, the cause of the exfoliation function is exfoliated by a moisturizer component, especially a moisturizer having a polyol group, among various cosmetic additives.
  • the present invention provides a cosmetic composition of a composition in which the exfoliating agent, in particular serine or carnitine, can maintain its effect. More specifically, the present invention was intended to provide a cosmetic for serine or carnitine that imparted a keratin exfoliation effect superior to the efficacy of the existing efficacy ingredient at mildly acidic-neutral pH without stimulation.
  • a moisturizer having a polyol group in the serine or carnitine such as glycerin (Glycerin), dipropylene glycol (Dipropylene glycol, DPG) and 1,3-butylene glycol (Butylene glycol, BG) was confirmed that the keratin exfoliation effect is sharply reduced when more than a certain concentration of polyol, such as one or more. Accordingly, the present invention provides within the scope that does not substantially include the polyol humectant component in serine or carnitine or significantly reduce its effects.
  • the present invention provides a cosmetic composition for enhancing keratin exfoliation that includes a keratin exfoliant and substantially does not include a polyol moisturizer.
  • the term "substantially free” refers to up to 2% by weight, preferably up to 1% by weight, more preferably up to 0.5% by weight, more preferably up to 0.3% by weight relative to the total weight of the composition. Even more preferably 0.1% by weight or less, most preferably no content at all.
  • the moisturizer having a polyol group is a raw material which is very widely used in cosmetic compositions as much as purified water, in particular, in the case of keratin exfoliation products to provide a cosmetic composition for enhancing keratin exfoliation including a polyol moisturizing agent in that a moisturizing is required more than usual. Is a problem.
  • the present invention provides a cosmetic composition for enhancing skin exfoliation, including a polyol moisturizer, in addition to the exfoliating agent.
  • a cosmetic composition for enhancing skin exfoliation including a polyol moisturizer, in addition to the exfoliating agent.
  • the composition of the present invention includes the polyol moisturizing agent, it is contained in an amount of more than 0 to 10% by weight, preferably more than 0 to 2% by weight, more preferably more than 0 to 0.5% by weight.
  • the moisturizer content is out of the above numerical range, keratin exfoliation effect is significantly reduced, the content range has a critical significance.
  • the term "exfoliation” means that keratin accumulated in the stratum corneum of the skin is eliminated or removed from the stratum corneum of the skin. It is a concept that includes both the case of removing from the stratum corneum of the skin only by the treatment of the cosmetic composition without applying a separate force as well as when removed by applying a physical force.
  • the exfoliating agent of the cosmetic composition for enhancing exfoliation of the present invention may be any one or more of serine and carnitine.
  • the exfoliating agent of the cosmetic composition for enhancing exfoliation of the present invention may be included in 0.001 to 20% by weight relative to the total composition weight, preferably 0.01 to 17% by weight, more preferably 0.05 to 15 wt% may be included.
  • the content thereof is less than 0.001% by weight, it may be difficult to obtain the desired effect, and when the content exceeds 20% by weight, the effect of increasing the content may be insignificant.
  • the polyol moisturizing agent of the cosmetic composition for enhancing keratin exfoliation of the present invention is glycerin (Glycerine), dipropylene glycol (DiGlycol, DPG), butylene glycol (Butylene Glycol, BG), glycerol Lys-26 (Glycereth-26), methylgluceth-20 (methyl gluceth-20) and pentylene glycol (Pentyleneglycol) may be at least one selected from the group consisting of, specifically glycerin, dipropylene glycol and 1, It may be at least one selected from the group consisting of 3-butylene glycol.
  • the polyol humectant of the cosmetic composition for enhancing exfoliation of the present invention may not be included or may be included in an amount of 10% by weight or less based on the total composition weight, preferably 5% by weight or less, more preferably. 2 wt% or less, more preferably 1 wt% or less, more preferably 0.5 wt% or less, more preferably 0.3 wt% or less, even more preferably 0.1 wt% or less. If their content is more than 10% by weight, it may be difficult to obtain a sufficient keratin exfoliation effect of the intended keratin exfoliant.
  • the cosmetic composition for enhancing exfoliation of the present invention may be pH 5 to 8, preferably 5 to 7.5, more preferably 5.5 to 7.
  • the cosmetic composition for promoting keratin exfoliation of the present invention may be optionally selected in addition to the above components, and optionally further selected according to the formulation or purpose of use of the cosmetic.
  • the compositions of each formulation may contain various bases and additives necessary and appropriate for the formulation of the formulation, and preservatives, thickeners, surfactants, silicone polymers, oxidative stabilizers, organics, etc. without departing from the effect thereof. It can be prepared including known compounds such as solvents, antioxidants, emollients, colorants, flavorings and the like.
  • the cosmetic composition according to the present invention was confirmed by the screening method by the skin exfoliation evaluation method and the human test method by DHA staining that shows excellent exfoliation effect even in the formulation containing a moisturizer having a polyol.
  • the activity of serine or carnitine in the neutral or weakly acidic pH range of 5-7 was equal to or higher than the effect of gluconolactone (PHA) or lactic acid (AHA) at pH 4 by porcine skin exfoliation assay. This was confirmed by the combination of the concentration of each material of the polyol humectant component.
  • the content of the polyol moisturizing agent is 0.1% by weight or more.
  • Exfoliation efficacy is drastically reduced, and when it exceeds 10% by weight, the exfoliation efficacy is not left at 0%, which is the capacity of water, which is a negative control, which means that the exfoliation ability does not appear significantly even in human tests.
  • the polyol moisturizing agent content is In the case of 10% and 50%, the number of keratin turnover days (TT100) compared to the existing ability did not appear to be significantly different from that of the non-coating 20 days. It was confirmed that the decrease to 17 days, preferably 14 days compared to the day.
  • the present invention is substantially free of the polyol humectant component since the keratin exfoliant serine or carnitine is reduced to an insignificant level of activity by the polyol humectant glycerin, dipropylene glycol, 1,3-butylene glycol. It provides within the range which does not significantly reduce the effect.
  • the exfoliating composition used in the present invention contains serine or carnitine, and contains substantially no one or more of the polyol moisturizing agents glycerin, dipropylene glycol, and 1,3-butylene glycol, or the effect thereof. It means the case selected within the range that does not reduce.
  • Combination Keratin exfoliation efficacy material (% by weight) Moisturizer with Polyol Group (% by weight) pH Serine Carnitine glycerin Dipropylene Glycol (DPG) 1,3-butylene glycol (1,3-BG)
  • DPG dipropylene Glycol
  • 1,3-BG 1,3-butylene glycol
  • Non-clinical keratin is difficult due to the conventional clinical evaluation method, which takes a long time, it is difficult to conduct all experiments with various concentrations and pH conditions of various raw materials, and it is difficult to conduct experiments for all cases of the composition combined from each raw material.
  • the necessity of peeling evaluation method has arisen.
  • the keratin exfoliation evaluation method described in the Journal of the European Academy of Dermatology and Venereology, 2014, 28, 415-423 was used.
  • the pig skin was biopted and the sample to be tested was added.
  • the number of exfoliated keratin was measured with a cell counter, and the sample containing water alone was plotted as a negative control (0%) and 10% gluconolactone pH 4 as a positive control (100%).
  • At least one selected from the group consisting of moisturizers glycerin, dipropylene glycol and 1,3-butylene glycol having a polyol group in combination with serine or carnitine shows keratin exfoliation efficacy when included in the range of 10% by weight or less. Therefore, it is necessary to use substantially no such moisturizer component or to use a specific concentration or less, preferably 10% by weight or less, to exhibit a significant exfoliation effect.
  • the exfoliation ability of serine and carnitine is influenced by the concentration of glycerol, dipropylene glycol, and 1,3-butylene glycol, which have polyol groups. It has been found that when there is no practical use or the use below 10%, the consumer can feel the effect.
  • Example 2 DHA Evaluation method of keratin turnover enhancement by staining method
  • DHA staining for the evaluation of keratin turnover rates was performed on 10 healthy males between 20 and 40 years of age using the method described in Dermatology 1993, 186, 133-137.
  • the color of the lower arm and upper arm of the test subject was measured with a chroma meter, and about 0.4 ml of dihydroxy acetone (DHA) at a concentration of 10% was added to 1.5 ⁇ 1.5 cm gauze. Buried and attached to the inside of the upper and lower arms for 8 hours. After 48 hours, the color of the brown colored area by DHA was measured to compare the color difference with that before the sample application.
  • DHA dihydroxy acetone
  • TT100% decreases about 6 days from 20 days to 14 days without coating, but it can be seen that there is no significant change in the concentration of glycerin 10% or 50% compared to the no coating group.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
PCT/KR2019/006806 2018-07-17 2019-06-05 각질 박리 증진용 화장료 조성물 Ceased WO2020017760A1 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN202411370951.8A CN119157765A (zh) 2018-07-17 2019-06-05 组合物在制造化妆品中的应用以及增强角质剥离的方法
US17/260,724 US20210267865A1 (en) 2018-07-17 2019-06-05 Cosmetic composition for increasing skin exfoliation
EP19838725.0A EP3824872B1 (en) 2018-07-17 2019-06-05 Cosmetic composition for increasing skin exfoliation
JP2021502856A JP7558606B2 (ja) 2018-07-17 2019-06-05 角質剥離増進用の化粧料組成物
CN201980047555.2A CN112423730B (zh) 2018-07-17 2019-06-05 角质剥离增强用化妆料组合物
JP2024071804A JP7726595B2 (ja) 2018-07-17 2024-04-25 角質剥離増進用の化粧料組成物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2018-0083069 2018-07-17
KR20180083069 2018-07-17
KR10-2019-0063704 2019-05-30
KR1020190063704A KR102253135B1 (ko) 2018-07-17 2019-05-30 각질 박리 증진용 화장료 조성물

Publications (1)

Publication Number Publication Date
WO2020017760A1 true WO2020017760A1 (ko) 2020-01-23

Family

ID=69165088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2019/006806 Ceased WO2020017760A1 (ko) 2018-07-17 2019-06-05 각질 박리 증진용 화장료 조성물

Country Status (4)

Country Link
EP (1) EP3824872B1 (https=)
JP (1) JP7726595B2 (https=)
CN (1) CN119157765A (https=)
WO (1) WO2020017760A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4306100A4 (en) * 2021-03-08 2025-03-19 LG Household & Health Care Ltd. COSMETIC COMPOSITION COMPRISING CARNITINE SALICYLATE AS ACTIVE INGREDIENT

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960040351A (ko) * 1995-05-11 1996-12-17 한동근 피부의 보습 및 각질연화 조성물
KR20050113669A (ko) * 2003-03-28 2005-12-02 론자 인코포레이티드 피부 외용 ｌ-카르니틴 조성물
KR100678865B1 (ko) * 2005-08-30 2007-02-05 주식회사 코리아나화장품 상지 추출물 및 카르니틴을 유효성분으로 함유하는 피부미백용 화장료 조성물
KR20100061881A (ko) * 2008-12-01 2010-06-10 주식회사 더페이스샵 각질 박리 촉진용 화장료 조성물
KR101165848B1 (ko) * 2005-08-18 2012-07-13 (주)아모레퍼시픽 효소 및 아미노산을 함유하는 피부 화장료 조성물
KR20180083069A (ko) 2017-01-12 2018-07-20 고려대학교 산학협력단 가상현실을 이용한 안과 검사 시스템 및 방법
KR20190063704A (ko) 2017-11-30 2019-06-10 롯데케미칼 주식회사 1,4-사이클로헥산디메탄올 제조 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11130650A (ja) * 1997-03-31 1999-05-18 Shiseido Co Ltd デスモソームの分解促進剤および角層剥離剤
DE852949T1 (de) * 1997-03-31 1998-11-19 Shiseido Co Ltd Verwendung von Alpha-Aminosäuren zur Förderung des desmosomalen Abbaues oder der Abschuppung der Hornschicht
JP3791731B2 (ja) * 1998-08-06 2006-06-28 株式会社ノエビア 角質剥離剤
JP2000063255A (ja) * 1998-08-12 2000-02-29 Shiseido Co Ltd 皮膚外用剤
ITMI20041603A1 (it) * 2004-08-04 2004-11-04 Vama Farmacosmetica S R L Materia prima cosmetica a base di 1-carnitina per preparato ad effetto idratante di lunga durata e preparato cosmetico ottenuto con questa materia prima
KR100678864B1 (ko) * 2005-08-30 2007-02-05 주식회사 코리아나화장품 천궁 추출물 및 카르니틴을 유효성분으로 함유하는 피부미백용 화장료 조성물
KR20080016186A (ko) * 2006-08-18 2008-02-21 조봉상 지방분해 기능을 갖는 코엔자임 에이, 엘-카르니틴 및카페인 혼합물, 피부재생기능을 갖는 아이쥐에프-1과천연필링기능을 갖는 화이트 윌로우박 추출물을 포함하는화장료 조성물.
US20150359732A1 (en) * 2013-03-13 2015-12-17 Avon Products, Inc. Vernonia cinerea extracts and methods of use
ES2910653T3 (es) * 2015-01-27 2022-05-13 Professional Dietetics S P A In Forma Abbreviata P D S P A Composiciones que comprenden a) quitosano, b) ácido glicólico, c) carnitina y/o n-acetilcisteína para el tratamiento de descamación dermoepidérmica
KR101934022B1 (ko) * 2017-12-04 2018-12-31 주식회사 엘지생활건강 피부 각질 박리 촉진용 화장용 조성물
KR102771004B1 (ko) * 2018-10-17 2025-02-21 주식회사 엘지생활건강 피부 각질 박리 촉진용 화장료 조성물

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960040351A (ko) * 1995-05-11 1996-12-17 한동근 피부의 보습 및 각질연화 조성물
KR20050113669A (ko) * 2003-03-28 2005-12-02 론자 인코포레이티드 피부 외용 ｌ-카르니틴 조성물
KR101165848B1 (ko) * 2005-08-18 2012-07-13 (주)아모레퍼시픽 효소 및 아미노산을 함유하는 피부 화장료 조성물
KR100678865B1 (ko) * 2005-08-30 2007-02-05 주식회사 코리아나화장품 상지 추출물 및 카르니틴을 유효성분으로 함유하는 피부미백용 화장료 조성물
KR20100061881A (ko) * 2008-12-01 2010-06-10 주식회사 더페이스샵 각질 박리 촉진용 화장료 조성물
KR20180083069A (ko) 2017-01-12 2018-07-20 고려대학교 산학협력단 가상현실을 이용한 안과 검사 시스템 및 방법
KR20190063704A (ko) 2017-11-30 2019-06-10 롯데케미칼 주식회사 1,4-사이클로헥산디메탄올 제조 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DERMATOLOGY, vol. 186, 1993, pages 133 - 137
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, vol. 28, 2014, pages 415 - 423

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4306100A4 (en) * 2021-03-08 2025-03-19 LG Household & Health Care Ltd. COSMETIC COMPOSITION COMPRISING CARNITINE SALICYLATE AS ACTIVE INGREDIENT

Also Published As

Publication number Publication date
EP3824872B1 (en) 2024-07-03
EP3824872A4 (en) 2022-04-27
JP7726595B2 (ja) 2025-08-20
EP3824872A1 (en) 2021-05-26
CN119157765A (zh) 2024-12-20
JP2024096233A (ja) 2024-07-12

Similar Documents

Publication Publication Date Title
DE69325366T2 (de) Verfahren zur hautpflege und mittel
WO2019112129A1 (ko) 피부 각질 박리 촉진용 화장용 조성물
WO2021006490A1 (ko) 그래핀 양자점을 유효성분으로 함유하는 화장료 조성물
WO2009136747A2 (ko) 줄기세포 배양액을 포함하는 화장료 조성물 및 이의 제조방법
WO2020226347A1 (ko) 피부 보습 화장료 조성물, 이를 이용한 화장품 및 이의 제조방법
WO2022149634A1 (ko) 저온 고압 효소 반응시킨 컬러 베이스 및 추출액을 함유하는 색조 화장료 조성물
WO2020017760A1 (ko) 각질 박리 증진용 화장료 조성물
CN114028246A (zh) 一种含有乙酰姜油酮的抗衰老修护组合物及应用
WO2018074642A1 (ko) 천연 세라마이드 및 로즈힙열매 오일을 유효성분으로 함유하는 입술 보호용 화장료 조성물
WO2017171404A1 (ko) 펜타사이클릭 트리터펜 카페익 액씨드 에스터를 포함하는 피부 보습 또는 피부 미백용 조성물
KR101717496B1 (ko) 클렌징 화장료 조성물
WO2010058986A2 (en) Cosmetic composition containing extracts of adenophora triphylla var. japonica hara, angelica tenuissima and medicinal herbs
WO2022211587A1 (ko) 신규한 스핑고모나스 파우치모빌리스 균주 및 이의 용도
KR20200008945A (ko) 각질 박리 증진용 화장료 조성물
WO2021010596A1 (ko) 산화 그래핀을 유효성분으로 함유하는 화장료 조성물
KR100824212B1 (ko) 태반을 함유하는 피부보호용 조성물 및 그의 제조방법
WO2024128370A1 (ko) 칡뿌리 추출물의 발효물을 포함하는 미백 또는 주름 개선용 화장료 조성물
WO2021242070A1 (ko) 피부탄력 증진 또는 피부주름 개선용 광반응성 화장료 조성물 및 이의 제조방법
HK40044303A (en) Cosmetic composition for increasing skin exfoliation
EP2153814A1 (en) Use of compositions comprising urea
WO2010140795A2 (ko) 인태반 유래 성장인자 및 사이토카인들을 함유한 유사 인태반 조성물 및 이의 화장품 용도
HK40044303B (zh) 角质剥离增强用化妆料组合物
WO2013077574A1 (ko) 데아닌 유도체를 함유하는 피부 외용제 조성물
KR102132538B1 (ko) 쌀겨 추출 화장료 부스터의 제조 방법, 화장료 부스터 및 이를 이용한 화장료 조성물
WO2025048546A1 (ko) 피부 개선용 조성물

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19838725

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2021502856

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2019838725

Country of ref document: EP

Effective date: 20210217