WO2019246435A1 - Systems and methods for dual-component drug agent delivery - Google Patents

Systems and methods for dual-component drug agent delivery Download PDF

Info

Publication number
WO2019246435A1
WO2019246435A1 PCT/US2019/038302 US2019038302W WO2019246435A1 WO 2019246435 A1 WO2019246435 A1 WO 2019246435A1 US 2019038302 W US2019038302 W US 2019038302W WO 2019246435 A1 WO2019246435 A1 WO 2019246435A1
Authority
WO
WIPO (PCT)
Prior art keywords
delivery system
fluid
hub
bfs
vial
Prior art date
Application number
PCT/US2019/038302
Other languages
English (en)
French (fr)
Inventor
Jay S. Walker
Marc Andrew Koska
Original Assignee
Koska Family Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/169,983 external-priority patent/US11382833B2/en
Application filed by Koska Family Limited filed Critical Koska Family Limited
Priority to CN201980052817.4A priority Critical patent/CN112543654B/zh
Priority to EP19823345.4A priority patent/EP3810230A4/en
Priority to JP2020571495A priority patent/JP2021527535A/ja
Priority to KR1020217001595A priority patent/KR20210049084A/ko
Publication of WO2019246435A1 publication Critical patent/WO2019246435A1/en
Priority to US17/129,593 priority patent/US20210128835A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
    • B29C49/04—Extrusion blow-moulding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/42—Component parts, details or accessories; Auxiliary operations
    • B29C49/4273—Auxiliary operations after the blow-moulding operation not otherwise provided for
    • B29C49/428—Joining
    • B29C49/42802—Joining a closure or a sealing foil to the article or pincing the opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/42—Component parts, details or accessories; Auxiliary operations
    • B29C49/4273—Auxiliary operations after the blow-moulding operation not otherwise provided for
    • B29C49/42808—Filling the article
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7158—Bottles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
PCT/US2019/038302 2018-06-20 2019-06-20 Systems and methods for dual-component drug agent delivery WO2019246435A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201980052817.4A CN112543654B (zh) 2018-06-20 2019-06-20 用于双组分药剂递送的系统和方法
EP19823345.4A EP3810230A4 (en) 2018-06-20 2019-06-20 SYSTEMS AND METHODS FOR DELIVERY OF ACTIVE AGENTS WITH TWO COMPONENTS
JP2020571495A JP2021527535A (ja) 2018-06-20 2019-06-20 二成分薬剤送達のためのシステムおよび方法
KR1020217001595A KR20210049084A (ko) 2018-06-20 2019-06-20 이중 성분 약물 제제 전달을 위한 시스템 및 방법
US17/129,593 US20210128835A1 (en) 2018-06-20 2020-12-21 Systems and methods for pre-filled dual-chamber medical agent delivery

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862687340P 2018-06-20 2018-06-20
US62/687,340 2018-06-20
US16/169,983 US11382833B2 (en) 2016-04-25 2018-10-24 Systems and methods for fluid delivery
US16/169,983 2018-10-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US17/129,593 Continuation-In-Part US20210128835A1 (en) 2018-06-20 2020-12-21 Systems and methods for pre-filled dual-chamber medical agent delivery

Publications (1)

Publication Number Publication Date
WO2019246435A1 true WO2019246435A1 (en) 2019-12-26

Family

ID=68984266

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/038302 WO2019246435A1 (en) 2018-06-20 2019-06-20 Systems and methods for dual-component drug agent delivery

Country Status (5)

Country Link
EP (1) EP3810230A4 (ko)
JP (1) JP2021527535A (ko)
KR (1) KR20210049084A (ko)
CN (1) CN112543654B (ko)
WO (1) WO2019246435A1 (ko)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021207040A1 (en) * 2020-04-05 2021-10-14 Koska Family Limited Systems and methods for pre-filled medical delivery devices
WO2022026275A1 (en) * 2020-07-30 2022-02-03 Koska Family Limited Systems and methods for pre-filled medical delivery assemblies
WO2022058906A1 (en) * 2020-09-21 2022-03-24 Orofino Pharmaceuticals Group Srl Deformable pre-packaged device for injecting a liquid
WO2022120269A1 (en) * 2020-12-04 2022-06-09 Koska Family Limited Systems and methods for rotational piercing of pre-filled medical delivery assemblies
US11382833B2 (en) 2016-04-25 2022-07-12 Koska Family Limited Systems and methods for fluid delivery
WO2022180488A1 (en) * 2021-02-26 2022-09-01 Koska Family Limited Pre-filled multi-fluid medical delivery assemblies
US11607369B2 (en) 2017-11-17 2023-03-21 Koska Family Limited Systems and methods for fluid delivery manifolds
WO2023049213A1 (en) * 2021-09-21 2023-03-30 Koska Family Limited Pre-filled blow-fill-seal intradermal injection system
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container
WO2023141120A1 (en) * 2022-01-18 2023-07-27 Credence Medsystems, Inc. Mixing and injection system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017001925A1 (en) * 2015-07-02 2017-01-05 Marc Andrew Koska Single use delivery device prefilled with a reconstitutable agent
WO2017125859A2 (en) * 2016-01-20 2017-07-27 Appelbaum Nicholas Generating a dosing aid label for a syringe
WO2017187262A1 (en) * 2016-04-25 2017-11-02 Marc Andrew Koska Medical delivery system
US9808608B2 (en) * 2014-11-16 2017-11-07 International Business Machines Corporation Helical coil delivery device for active agent

Family Cites Families (7)

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US5330426A (en) * 1992-08-13 1994-07-19 Science Incorporated Mixing and delivery syringe assembly
US7621887B2 (en) * 2000-10-10 2009-11-24 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
AR076716A1 (es) * 2009-06-02 2011-06-29 Sanofi Aventis Deutschland Modulo medicado con medicamento de premezcla
JP2013542791A (ja) * 2010-11-03 2013-11-28 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイスのための薬用モジュール
US9179260B2 (en) * 2012-12-03 2015-11-03 Mylan Inc. Medicament information system and method
AU2015331599B2 (en) * 2014-10-18 2020-11-05 Abbvie Inc. Wearable automatic injection system and apparatus
EP3031486A1 (en) * 2014-12-09 2016-06-15 CONARIS research institute AG Medication cartridges for optimised dosing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9808608B2 (en) * 2014-11-16 2017-11-07 International Business Machines Corporation Helical coil delivery device for active agent
WO2017001925A1 (en) * 2015-07-02 2017-01-05 Marc Andrew Koska Single use delivery device prefilled with a reconstitutable agent
WO2017125859A2 (en) * 2016-01-20 2017-07-27 Appelbaum Nicholas Generating a dosing aid label for a syringe
WO2017187262A1 (en) * 2016-04-25 2017-11-02 Marc Andrew Koska Medical delivery system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3810230A4 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11382833B2 (en) 2016-04-25 2022-07-12 Koska Family Limited Systems and methods for fluid delivery
US11607369B2 (en) 2017-11-17 2023-03-21 Koska Family Limited Systems and methods for fluid delivery manifolds
WO2021207040A1 (en) * 2020-04-05 2021-10-14 Koska Family Limited Systems and methods for pre-filled medical delivery devices
WO2022026275A1 (en) * 2020-07-30 2022-02-03 Koska Family Limited Systems and methods for pre-filled medical delivery assemblies
WO2022058906A1 (en) * 2020-09-21 2022-03-24 Orofino Pharmaceuticals Group Srl Deformable pre-packaged device for injecting a liquid
WO2022120269A1 (en) * 2020-12-04 2022-06-09 Koska Family Limited Systems and methods for rotational piercing of pre-filled medical delivery assemblies
WO2022180488A1 (en) * 2021-02-26 2022-09-01 Koska Family Limited Pre-filled multi-fluid medical delivery assemblies
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container
WO2023049213A1 (en) * 2021-09-21 2023-03-30 Koska Family Limited Pre-filled blow-fill-seal intradermal injection system
WO2023141120A1 (en) * 2022-01-18 2023-07-27 Credence Medsystems, Inc. Mixing and injection system

Also Published As

Publication number Publication date
EP3810230A4 (en) 2022-03-23
CN112543654B (zh) 2024-01-05
CN112543654A (zh) 2021-03-23
JP2021527535A (ja) 2021-10-14
EP3810230A1 (en) 2021-04-28
KR20210049084A (ko) 2021-05-04

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