WO2019228250A1 - 一种骨髓涂片数字化的流程方法 - Google Patents
一种骨髓涂片数字化的流程方法 Download PDFInfo
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- WO2019228250A1 WO2019228250A1 PCT/CN2019/088157 CN2019088157W WO2019228250A1 WO 2019228250 A1 WO2019228250 A1 WO 2019228250A1 CN 2019088157 W CN2019088157 W CN 2019088157W WO 2019228250 A1 WO2019228250 A1 WO 2019228250A1
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- Prior art keywords
- bone marrow
- physical
- smear
- area
- smears
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- 210000001185 bone marrow Anatomy 0.000 title claims abstract description 71
- 238000000034 method Methods 0.000 title claims abstract description 28
- 230000008569 process Effects 0.000 title claims abstract description 13
- 210000004027 cell Anatomy 0.000 claims abstract description 30
- 210000003593 megakaryocyte Anatomy 0.000 claims abstract description 22
- 238000012546 transfer Methods 0.000 claims description 12
- 210000002798 bone marrow cell Anatomy 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 2
- 238000000386 microscopy Methods 0.000 abstract description 8
- 238000011161 development Methods 0.000 abstract description 3
- 238000007654 immersion Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 description 8
- 238000007689 inspection Methods 0.000 description 7
- 230000000877 morphologic effect Effects 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000010186 staining Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 208000008720 Bone Marrow Neoplasms Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 206010033661 Pancytopenia Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000006491 bone marrow cancer Diseases 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000000093 cytochemical effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000011206 morphological examination Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0669—Bone marrow stromal cells; Whole bone marrow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Definitions
- the invention belongs to the field of computer medicine bone marrow smear examination, and in particular relates to a method for digitizing a bone marrow smear.
- Morphological examination of bone marrow cells is one of the key diagnostic methods in hematology. It is often used to diagnose a variety of conditions, including leukemia, multiple myeloma, lymphoma, anemia, and pancytopenia. According to the "Guidelines for the Diagnosis of Bone Marrow Tumors" issued by the World Health Organization, detailed and accurate manual microscopic examination is required during diagnosis.
- Normal bone marrow contains all differentiated cells at developmental stage, from early precursor stem cells to functional mature cells, including hematopoietic stem cells, which are precursors of most blood cells, and mesenchymal stem cells and endothelial stem cells, which are considered gatekeeper cells of the bone marrow.
- the technical problem to be solved by the present invention is to provide a method for digitizing a bone marrow smear, which converts a physical bone marrow smear into a digital smear. Simplify the process of manual microscopy; improve the consistency and standardization of bone marrow examination report results; facilitate remote consultations, reduce the turnaround time of physical smears, especially for special samples; provide continuous education for all employees, and improve bone marrow morphology experience.
- a method for digitizing a bone marrow smear including the following steps:
- the specific area in the step (5) is a label area of the slide, wherein the slide is divided into a label area and a detection area by a horizontal scale line.
- the advantages of the present invention are: converting bone marrow physical smears into digital smears, simplifying the process of manual microscopy; improving the consistency and standardization of bone marrow examination report results; facilitating remote consultation and reducing the turnaround time of physical smears, especially for special Sample; Provide continuous education for all employees to improve bone marrow morphology experience.
- Embodiment 1 The embodiment of the present invention is a method for digitizing a bone marrow smear, which includes the following steps:
- the industrial application of the invention and its advantages transform bone marrow physical smears into digital smears, simplify the process of manual microscopy; improve the consistency and standardization of bone marrow examination report results; facilitate remote consultation and reduce the turnaround time of physical smears , Especially special samples; provide continuous education for all employees to improve bone marrow morphology experience.
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Multimedia (AREA)
- Medicinal Chemistry (AREA)
- Educational Administration (AREA)
- Algebra (AREA)
- Computational Mathematics (AREA)
- Mathematical Analysis (AREA)
- Mathematical Optimization (AREA)
- Mathematical Physics (AREA)
- Pure & Applied Mathematics (AREA)
- Business, Economics & Management (AREA)
- Medical Informatics (AREA)
- Educational Technology (AREA)
- Theoretical Computer Science (AREA)
- Signal Processing (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
Claims (2)
- 一种骨髓涂片数字化的流程方法,其特征在于,包括如下步骤:(1)获取骨髓物理涂片相关的病历信息;(2)生成骨髓物理涂片的全局图像;(3)生成骨髓物理涂片的待数字化区域以及有核细胞采集数量和巨核细胞分类数量;(4)生成该骨髓物理涂片的数字标签;(5)打印并将数字标签粘贴在对应的骨髓物理涂片的特定区域;(6)重复(1)~(5)步骤,直至生成并粘贴所有骨髓物理涂片的数字标签;(7)将带有数字标签的骨髓物理涂片装入玻片盒;(8)将玻片盒装入骨髓细胞扫描设备的入口;(9)将玻片盒传送至扫描设备的上片位;(10)通过红外扫描结构确认并记录玻片盒中有骨髓物理涂片的位置;(11)将骨髓物理涂片从玻片盒传送至载物台;(12)读取骨髓物理涂片的数字标签;(13)切换至低倍镜扫描(3)生成的待数字化区域并标记和识别其中的目标观察物;(14)生成(13)扫描区域的拼接图像;(15)切换至高倍镜扫描(3)生成的巨核细胞分类数量的巨核细胞,标记并识别巨核细胞;(16)生成(15)扫描的巨核细胞图像;(17)在骨髓物理涂片上滴加专用镜油;(18)切换至油镜扫描(3)生成的待数字化区域里的有核细胞采集数量的有核细胞,标记并识别;(19)生成(18)扫描的有核细胞图像;(20)生成骨髓物理涂片的数字化涂片;(21)将骨髓物理涂片从载物台传送至玻片盒;(22)重复(11)~(21)步骤,直至玻片盒中所有的骨髓物理涂片都生成数字化涂片;(23)将玻片盒从上片位传送至专用的扫描设备的入口;(24)取出玻片盒,完成了骨髓涂片数字化的全部过程。
- 根据权利要求1所述的一种骨髓涂片数字化的流程方法,其特征在于,所述步骤(5)中的特定区域为玻片的标签区,其中玻片通过横向刻度线分为标签区和检测区。
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/979,499 US11802820B2 (en) | 2018-05-28 | 2019-05-23 | Method for digitizing bone marrow smear |
EP19811683.2A EP3805764B1 (en) | 2018-05-28 | 2019-05-23 | Process method for bone marrow smear digitization |
RU2020133613A RU2755247C1 (ru) | 2018-05-28 | 2019-05-23 | Способ оцифровывания мазка пунктата костного мозга |
AU2019277871A AU2019277871B2 (en) | 2018-05-28 | 2019-05-23 | Process method for bone marrow smear digitization |
KR1020207030280A KR102489789B1 (ko) | 2018-05-28 | 2019-05-23 | 골수 도판의 디지털화 플로우 방법 |
JP2020548683A JP7004354B2 (ja) | 2018-05-28 | 2019-05-23 | 骨髄塗抹標本のデジタル化のための方法 |
IL277043A IL277043A (en) | 2018-05-28 | 2020-08-31 | A method for bone marrow surface digitization |
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CN201810522618.2 | 2018-05-28 | ||
CN201810522618.2A CN108896363A (zh) | 2018-05-28 | 2018-05-28 | 一种骨髓涂片数字化的流程方法 |
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WO2019228250A1 true WO2019228250A1 (zh) | 2019-12-05 |
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PCT/CN2019/088157 WO2019228250A1 (zh) | 2018-05-28 | 2019-05-23 | 一种骨髓涂片数字化的流程方法 |
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US (1) | US11802820B2 (zh) |
EP (1) | EP3805764B1 (zh) |
JP (1) | JP7004354B2 (zh) |
KR (1) | KR102489789B1 (zh) |
CN (1) | CN108896363A (zh) |
AU (1) | AU2019277871B2 (zh) |
IL (1) | IL277043A (zh) |
RU (1) | RU2755247C1 (zh) |
TW (1) | TWI746984B (zh) |
WO (1) | WO2019228250A1 (zh) |
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CN108896363A (zh) * | 2018-05-28 | 2018-11-27 | 杭州智微信息科技有限公司 | 一种骨髓涂片数字化的流程方法 |
CN111833296B (zh) * | 2020-05-25 | 2023-03-10 | 中国人民解放军陆军军医大学第二附属医院 | 一种骨髓细胞形态学自动检测审核系统及审核方法 |
CN114018924A (zh) * | 2021-11-23 | 2022-02-08 | 杭州智微信息科技有限公司 | 一种自动检测尿脱落细胞中异常细胞的方法 |
CN114252971B (zh) * | 2021-12-31 | 2023-09-05 | 杭州智微信息科技有限公司 | 一种用于骨髓涂片的自动对焦方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1553166A (zh) * | 2003-12-19 | 2004-12-08 | 武汉大学 | 显微多光谱骨髓及外周血细胞自动分析仪和方法 |
CN1582327A (zh) * | 2001-09-06 | 2005-02-16 | 基因描绘系统有限公司 | 复制细胞的快速检测 |
CN103827655A (zh) * | 2011-07-22 | 2014-05-28 | 罗氏血液诊断股份有限公司 | 样品运送系统及方法 |
US20170176481A1 (en) * | 2015-12-18 | 2017-06-22 | Abbott Laboratories | Systems and Methods for Automated Analysis |
CN107478484A (zh) * | 2010-11-10 | 2017-12-15 | 罗氏血液诊断股份有限公司 | 制备用于检查的生物标本的自动化系统及方法 |
CN107849738A (zh) * | 2015-02-16 | 2018-03-27 | 密执安州立大学董事会 | 用于进行免疫测定的系统和方法 |
CN108896363A (zh) * | 2018-05-28 | 2018-11-27 | 杭州智微信息科技有限公司 | 一种骨髓涂片数字化的流程方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2143686C1 (ru) * | 1998-05-19 | 1999-12-27 | Гусев Александр Анатольевич | Способ исследования биологических материалов и устройство для его осуществления |
US20020186875A1 (en) * | 2001-04-09 | 2002-12-12 | Burmer Glenna C. | Computer methods for image pattern recognition in organic material |
US7219016B2 (en) * | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
US7272252B2 (en) * | 2002-06-12 | 2007-09-18 | Clarient, Inc. | Automated system for combining bright field and fluorescent microscopy |
CN1308230C (zh) | 2005-06-17 | 2007-04-04 | 吉林大学 | 一种高度水溶性碳纳米管的制备方法 |
RU2308745C1 (ru) * | 2006-10-09 | 2007-10-20 | Государственное образовательное учреждение высшего профессионального образования Московский инженерно-физический институт (государственный университет) | Способ микроскопического исследования образца, содержащего микрообъекты с разнородными зонами |
US9607372B2 (en) * | 2007-07-11 | 2017-03-28 | Hernani D. Cualing | Automated bone marrow cellularity determination |
US8748186B2 (en) * | 2009-12-22 | 2014-06-10 | Abbott Laboratories | Method for performing a blood count and determining the morphology of a blood smear |
CN103006883A (zh) * | 2012-12-25 | 2013-04-03 | 青岛市市立医院 | 一种治疗血小板减少症的药物组合物及其制备方法 |
CN103966020A (zh) * | 2014-04-29 | 2014-08-06 | 周凡 | 一种香柏油脱油处理的方法 |
-
2018
- 2018-05-28 CN CN201810522618.2A patent/CN108896363A/zh active Pending
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2019
- 2019-05-23 JP JP2020548683A patent/JP7004354B2/ja active Active
- 2019-05-23 AU AU2019277871A patent/AU2019277871B2/en active Active
- 2019-05-23 EP EP19811683.2A patent/EP3805764B1/en active Active
- 2019-05-23 US US16/979,499 patent/US11802820B2/en active Active
- 2019-05-23 KR KR1020207030280A patent/KR102489789B1/ko active IP Right Grant
- 2019-05-23 WO PCT/CN2019/088157 patent/WO2019228250A1/zh active Application Filing
- 2019-05-23 RU RU2020133613A patent/RU2755247C1/ru active
- 2019-05-27 TW TW108118261A patent/TWI746984B/zh active
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- 2020-08-31 IL IL277043A patent/IL277043A/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1582327A (zh) * | 2001-09-06 | 2005-02-16 | 基因描绘系统有限公司 | 复制细胞的快速检测 |
CN1553166A (zh) * | 2003-12-19 | 2004-12-08 | 武汉大学 | 显微多光谱骨髓及外周血细胞自动分析仪和方法 |
CN107478484A (zh) * | 2010-11-10 | 2017-12-15 | 罗氏血液诊断股份有限公司 | 制备用于检查的生物标本的自动化系统及方法 |
CN103827655A (zh) * | 2011-07-22 | 2014-05-28 | 罗氏血液诊断股份有限公司 | 样品运送系统及方法 |
CN107849738A (zh) * | 2015-02-16 | 2018-03-27 | 密执安州立大学董事会 | 用于进行免疫测定的系统和方法 |
US20170176481A1 (en) * | 2015-12-18 | 2017-06-22 | Abbott Laboratories | Systems and Methods for Automated Analysis |
CN108896363A (zh) * | 2018-05-28 | 2018-11-27 | 杭州智微信息科技有限公司 | 一种骨髓涂片数字化的流程方法 |
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Publication number | Publication date |
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JP7004354B2 (ja) | 2022-01-21 |
AU2019277871B2 (en) | 2021-07-08 |
EP3805764A4 (en) | 2022-03-16 |
KR20200135460A (ko) | 2020-12-02 |
TWI746984B (zh) | 2021-11-21 |
US20210096045A1 (en) | 2021-04-01 |
US11802820B2 (en) | 2023-10-31 |
JP2021517642A (ja) | 2021-07-26 |
AU2019277871A1 (en) | 2020-08-27 |
EP3805764A1 (en) | 2021-04-14 |
RU2755247C1 (ru) | 2021-09-14 |
EP3805764B1 (en) | 2024-01-10 |
EP3805764C0 (en) | 2024-01-10 |
CN108896363A (zh) | 2018-11-27 |
TW202012904A (zh) | 2020-04-01 |
KR102489789B1 (ko) | 2023-01-17 |
IL277043A (en) | 2020-10-29 |
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