WO2019181510A1 - Produit aérosol - Google Patents

Produit aérosol Download PDF

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Publication number
WO2019181510A1
WO2019181510A1 PCT/JP2019/008878 JP2019008878W WO2019181510A1 WO 2019181510 A1 WO2019181510 A1 WO 2019181510A1 JP 2019008878 W JP2019008878 W JP 2019008878W WO 2019181510 A1 WO2019181510 A1 WO 2019181510A1
Authority
WO
WIPO (PCT)
Prior art keywords
component
mass
stock solution
aerosol product
propellant
Prior art date
Application number
PCT/JP2019/008878
Other languages
English (en)
Japanese (ja)
Inventor
拓也 山科
康輝 稲田
敏郎 松村
Original Assignee
株式会社マンダム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社マンダム filed Critical 株式会社マンダム
Priority to JP2020508170A priority Critical patent/JPWO2019181510A1/ja
Publication of WO2019181510A1 publication Critical patent/WO2019181510A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants

Definitions

  • the present invention relates to an aerosol product.
  • bactericidal composition containing a bactericidal component such as triclosan or isopropylmethylphenol and a lysozyme (salt) such as lysozyme chloride is known (Patent Document 1).
  • lysozyme chloride is water-soluble, when preparing a composition containing lysozyme chloride, it is common to select a water-based formulation.
  • dimethyl ether having a relatively high solubility in water is generally used as a propellant.
  • an object of the present invention is to provide an aerosol product having a composition containing lysozyme chloride and water as a stock solution, in which deactivation of lysozyme chloride is suppressed.
  • the present invention is an aerosol product in which a container body is filled with a stock solution and a propellant,
  • the stock solution relates to an aerosol product containing the following component A, component B and component C, and the propellant containing liquefied petroleum gas.
  • Component A Lysozyme chloride
  • Component B Nonionic surfactant
  • Component C Water
  • the aerosol product of the present invention is an aerosol product using a water-based composition containing lysozyme chloride as a stock solution, the deactivation of lysozyme chloride is suppressed, that is, the stability of lysozyme chloride is high. Play.
  • lysozyme chloride As a result of further investigation by the inventors, as a stock solution, lysozyme chloride, a nonionic surfactant, and water were used, and a water-insoluble liquefied petroleum gas was used as a propellant. It was found that the stability of lysozyme chloride can be improved unexpectedly by using an aerosol product emulsified with liquefied petroleum gas, and the present invention has been completed.
  • lysozyme chloride In the composition containing lysozyme chloride and water, since water is a good solvent for lysozyme chloride, lysozyme chloride can exist stably without being deactivated.
  • the aerosol product having the above composition as a stock solution when dimethyl ether having high solubility in water is used as a propellant, dimethyl ether is dissolved in the water in the stock solution, and the solubility of lysozyme chloride in water decreases. Conceivable. As a result, it is presumed that lysozyme chloride is denatured or lysozyme chloride aggregates and is inactivated.
  • water is maintained as a good solvent for lysozyme chloride by deliberately using liquefied petroleum gas having low solubility in water as a propellant, and deactivation of lysozyme chloride is suppressed. That is, it is presumed that the effect of high stability of lysozyme chloride is exerted.
  • the stock solution in the aerosol product of the present invention contains component A: lysozyme chloride, component B: nonionic surfactant, and component C: water as essential components.
  • the aerosol product of the present invention preferably further contains component D: ethanol in addition to the essential components. Further, components other than component A to component D (other components) may be further contained. Each of Component A to Component D and other components may be used alone or in combination of two or more.
  • Component A is lysozyme chloride.
  • Component A is a polysaccharide hydrolase that is a component of the bacterial cell membrane, and has pharmacological actions such as lysis.
  • Component A can be easily obtained as a commercial product.
  • the content of component A in 100% by mass of the stock solution in the present invention is preferably 0.1% by mass or more, more preferably 0.15% by mass or more, from the viewpoint of achieving a sufficient bactericidal effect. From the viewpoint of cost effectiveness and solubility in the stock solution, it is preferably 1.5% by mass or less, and more preferably 1.0% by mass or less.
  • Component B is a nonionic surfactant, and the stability as a preparation can be improved by stably emulsifying the liquefied petroleum gas contained in the stock solution and the propellant.
  • Component B may be used alone or in combination of two.
  • Component B includes alkyl glucoside, glycerin fatty acid ester, polyglycerin fatty acid ester, ethylene oxide condensate of glycerin fatty acid ester, polyethylene glycol fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, ethylene oxide condensate of sorbitan fatty acid ester, poly Examples thereof include oxyalkylene alkyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, and polyoxyethylene lanolin.
  • glycerin fatty acid esters include glyceryl monocaprylate, glyceryl monocaprate, glyceryl monolaurate, glyceryl monomyristate, glyceryl monopalmitate, glyceryl monostearate, glyceryl monoisostearate, glyceryl monobehenate, monooleic acid
  • glyceryl, glyceryl monoerucate, glyceryl sesquioleate, glyceryl distearate, glyceryl diisostearate, and glyceryl diarachiate examples include glyceryl, glyceryl monoerucate, glyceryl sesquioleate, glyceryl distearate, glyceryl diisostearate, and glyceryl diarachiate.
  • polyglyceryl fatty acid ester examples include diglyceryl monocaprylate, decaglyceryl monocaprylate, hexaglyceryl monocaprate, tetraglyceryl monolaurate, hexaglyceryl monolaurate, decaglyceryl monolaurate, poly (4 to 10 polylaurate) ) Glyceryl, decaglyceryl monomyristate, decaglyceryl monostearate, decaglyceryl monoisostearate, poly (2-10) glyceryl monostearate, diglyceryl monooleate, hexaglyceryl monooleate, diglyceryl sesquioleate, Poly (2-10) glyceryl diisostearate, poly (6-10) glyceryl distearate, diglyceryl triisostearate, poly (10) glyceryl tristearate Like it is exemplified.
  • ethylene oxide condensate of glycerin fatty acid ester examples include polyoxyethylene glyceryl monostearate and polyoxyethylene glyceryl monooleate.
  • polyethylene glycol fatty acid ester examples include polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, and the like.
  • polyethylene glycol monolaurate for example, trade name “Emanon 1112” (manufactured by Kao Corporation, average added mole number of oxyethylene group: 12) and the like can be mentioned.
  • propylene glycol fatty acid ester examples include propylene glycol monostearate, propylene glycol monolaurate, propylene glycol monooleate and the like.
  • sorbitan fatty acid esters include sorbitan monooleate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monopalmitate, sorbitan monolaurate, sorbitan trioleate, sorbitan tristearate, sorbitan sesquistearate, sesquiolein Examples include acid sorbitan, sorbitan sesquiisostearate, coconut oil fatty acid sorbitan, and the like.
  • ethylene oxide condensate of sorbitan fatty acid ester examples include polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene monoisostearate
  • examples include ethylene sorbitan, mono coconut oil fatty acid polyoxyethylene sorbitan, polystearic acid polyoxyethylene sorbitan, and trioleic acid polyoxyethylene sorbitan.
  • polyoxyethylene sorbitan monostearate examples include trade name “Rheidol TW-S120V” (manufactured by Kao Corporation, average added mole number of oxyethylene groups: 20).
  • Examples of commercially available polyoxyethylene hydrogenated castor oil include trade name “EMALEX HC-20” (manufactured by Nippon Emulsion Co., Ltd.), trade name “EMALEX HC-50” (manufactured by Japan Emulsion Co., Ltd.), and the like.
  • Preferred oxyalkylene groups in the polyoxyalkylene alkyl ether include oxyethylene groups and oxypropylene groups.
  • the average added mole number of the oxyalkylene group in the polyoxyalkylene alkyl ether is preferably 8 to 42, more preferably 10 to 40.
  • the oxyalkylene group in the polyoxyalkylene alkyl ether may be only one type, or two or more types, for example, a polyoxyethylene polyoxypropylene (POEPOP) group in which an oxyethylene group and an oxypropylene group are combined.
  • POEPOP polyoxyethylene polyoxypropylene
  • the average added mole number when the oxyalkylene group in the polyoxyalkylene alkyl ether contains two or more oxyalkylene groups is the total of the average added mole numbers of the two or more oxyalkylene groups.
  • the alkyl group in the polyoxyalkylene alkyl ether is preferably a saturated or unsaturated group having 12 to 28 carbon atoms. Specific examples include a lauryl group, a cetyl group, a stearyl group, an oleyl group, an isocetyl group, a decyltetradecyl group, and the like.
  • polyoxyalkylene alkyl ether examples include polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene polyoxypropylene lauryl ether, polyoxypropylene cetyl ether, Examples include polyoxypropylene isocetyl ether, polyoxypropylene stearyl ether, polyoxypropylene oleyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene polyoxypropylene cetyl ether and the like. Among these, polyoxyethylene polyoxypropylene decyl tetradecyl ether is preferable from the viewpoint of easily obtaining a cracking spray that emits a cracking sound.
  • polyoxyalkylene alkyl ether As a commercially available product of polyoxyalkylene alkyl ether, for example, as a polyoxyethylene polyoxypropylene decyl tetradecyl ether, a trade name “Nikkol PEN-4612” (manufactured by Nikko Chemicals, average added mole number of oxyethylene group: 12, Average addition mole number of oxypropylene group: 6), trade name “Nikkol PEN-4630” (manufactured by Nikko Chemicals, average addition mole number of oxyethylene group: 30, average addition mole number of oxypropylene group: 6); poly Examples of the oxyethylene polyoxypropylene cetyl ether include trade name “PBC-44” (manufactured by Nippon Surfactant Kogyo Co., Ltd., average added mole number of oxyethylene group: 20, average added mole number of oxypropylene group: 8) and the like. .
  • the content of component B in 100% by mass of the stock solution in the present invention is preferably 0.05% by mass or more, more preferably 0.1% by mass from the viewpoint of stably emulsifying the stock solution and liquefied petroleum gas. On the other hand, from the viewpoint of suppressing stickiness and odor derived from component B, it is preferably 1.5% by mass or less, and more preferably 1.0% by mass or less.
  • the content of component B is the total amount of all components B contained in the stock solution.
  • Component C is water. Component C serves as a medium in the stock solution.
  • the content of Component C in 100% by mass of the stock solution in the present invention is preferably 55.0% by mass or more, more preferably 60.0% by mass or more, from the viewpoint of improving the stability of Component A, and more preferably Preferably, it is 65.0% by mass or more.
  • it is preferably 99.0% by mass or less, more preferably 90.0% by mass or less, and further Preferably it is 85.0 mass% or less.
  • the stock solution in the aerosol product of the present invention preferably further contains component D ethanol.
  • the content of the component D in 100% by mass of the stock solution in the present invention is that the quick drying property is imparted to the discharged product, the user is given a feeling of cooling, or the components other than the components A and C are added to the stock solution. From the viewpoint of improving the solubility, it is preferably 1.0% by mass or more, more preferably 10.0% by mass or more, while from the viewpoint of the stability of Component A, preferably 30.0% by mass or less. More preferably, it is 25.0 mass% or less, More preferably, it is 22.0 mass% or less.
  • the stock solution in the aerosol product of the present invention can optionally contain components other than component A to component D (other components).
  • Other components include, for example, bactericides other than Component A such as benzalkonium chloride, benzethonium chloride, halocarban, trichlorocarbanilide, chlorhexidine hydrochloride, isopropylmethylphenol, triclosan, and chlorhexidine gluconate; aluminum chloride, aluminum sulfate Antiperspirant components such as potassium, aluminum sulfate, aluminum acetate, chlorohydroxyaluminum, allantoin chlorohydroxyaluminum and zinc paraphenol sulfonate; metal oxides (such as zinc oxide), alkyldiethanolamide, hydroxyapatite, tea extract, fragrance Deodorant ingredients such as antioxidants, surfactants other than Component B, coloring agents, chelating agents, refreshing agents, vitamins, neutralizing agents, amino acids, pH adjusting agents, whitening agents, anti-inflammatory agents,
  • the stock solution can be prepared by a conventional method.
  • the above-described constituent components are mixed and a known method, specifically, a method of stirring with a homomixer or the like can be mentioned.
  • the propellant in the aerosol product of the present invention contains liquefied petroleum gas. It does not specifically limit as liquefied petroleum gas,
  • the liquefied petroleum gas used for aerosol products can be employ
  • the content of liquefied petroleum gas in 100% by mass of the propellant is preferably 95.0% by mass or more, more preferably 100% by mass, from the viewpoint of injection stability.
  • propellants that can be used in combination with liquefied petroleum gas include compressed gas such as nitrogen gas and carbon dioxide gas.
  • the propellant is liquefied petroleum gas and compressed gas alone or liquefied petroleum. Preferably only gas.
  • the propellant in the aerosol product of the present invention preferably does not contain a liquefied gas having high solubility in water such as dimethyl ether.
  • the mass ratio of the stock solution to the propellant is preferably 20/80 or more, more preferably from the viewpoint of facilitating emulsification of the liquefied petroleum gas and the stock solution. 30/70 or more.
  • 95/5 or less is preferable from the viewpoint of securing the momentum of injection, the viewpoint of giving a refreshing feeling during use, the viewpoint of improving the cooling feeling by liquefied petroleum gas, or the viewpoint of injecting the stock solution to the end, and 92/8 or less More preferred.
  • the aerosol product of the present invention can be produced by filling an aerosol container with a stock solution and a propellant by a conventional method.
  • Spray form foam form, etc. are mentioned as the discharge form of aerosol products.
  • spray form it is also possible to provide a cracking spray that emits a cracking sound and cracking sound immediately after discharge, and can give an appropriate stimulation to the discharge surface.
  • the parts to which the aerosol product of the present invention is applied include the scalp, face (for example, forehead, eyes, eyes, cheeks, mouth, etc.), arms, elbows, back of hands, fingertips, feet, knees, heels, neck, heel, back, etc. Is mentioned.
  • the aerosol product of the present invention can be uniformly injected in a state in which the stock solution and liquefied petroleum gas are emulsified, the user feels a refreshing feeling due to the momentum of injection and a cooling feeling due to volatilization of the liquefied petroleum gas. Can do. Therefore, the use to an antiperspirant, a deodorant, an antiperspirant deodorant, and a deodorant agent is preferable.
  • a discharge form is a cracking spray, it is more preferable to set it as a deodorant agent.
  • the aerosol product of the present invention may be, for example, any of cosmetics, quasi drugs, medicines, and miscellaneous goods.
  • Examples 1 to 10, Comparative Examples 1 to 7 Manufacture of aerosol products
  • the stock solution having the composition described in Table 1 and Table 2 was filled into an aerosol container ( ⁇ 35 mm ⁇ 105 mm, aluminum can, full container amount: 91 mL), and an aerosol valve was clinched into the container.
  • a propellant liquefied petroleum gas or dimethyl ether
  • the total amount of the stock solution and the propellant filled in the aerosol container was 40 g in any of the examples and comparative examples.
  • the titer of lysozyme chloride in each discharge was determined by the method described in the 17th revision Japanese Pharmacopoeia “Lysozyme Hydrochloride”.
  • the ejected material was ejected from the stem of each test aerosol product, and the obtained propellant was subjected to ultrasonic treatment to volatilize the remaining propellant as a sample sample.
  • a sample solution was appropriately diluted with a pH 6.2 phosphate buffer. 3 mL of the sample solution heated in a 35 ° C. water bath was added to 3 mL of pH 6.2 phosphate buffer and 3 mL of a substrate solution for lysozyme chloride (Micrococcus lysodeikticus at pH 6.2).
  • a lysozyme standard solution a solution obtained by diluting a quantified lysozyme chloride standard product with a pH 3.0 hydrochloric acid solution.
  • the aerosol product manufactured in the above preferable range can uniformly inject the stock solution and the liquefied petroleum gas, so that the user can feel the refreshing feeling due to the momentum of the injection and the cooling feeling due to the volatilization of the liquefied petroleum gas. . Therefore, the use to a deodorant agent and a refreshing agent, such as a bad smell inhibitor, is preferable.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un produit aérosol ayant un concentré liquide et un agent propulseur chargé dans un corps d'un récipient, le concentré liquide contenant des composants A, B et C indiqués ci-dessous, et le propulseur contenant un gaz de pétrole liquéfié. Un tel produit d'aérosol présente une stabilité élevée du chlorure de lysozyme, et est ainsi de préférence applicable à une utilisation dans des agents déodorants. Composant A : chlorure de lysozyme. Composant B : tensioactif non ionique. Composant C : eau.
PCT/JP2019/008878 2018-03-19 2019-03-06 Produit aérosol WO2019181510A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020508170A JPWO2019181510A1 (ja) 2018-03-19 2019-03-06 エアゾール製品

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018-050950 2018-03-19
JP2018050950 2018-03-19

Publications (1)

Publication Number Publication Date
WO2019181510A1 true WO2019181510A1 (fr) 2019-09-26

Family

ID=67987823

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2019/008878 WO2019181510A1 (fr) 2018-03-19 2019-03-06 Produit aérosol

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JP (1) JPWO2019181510A1 (fr)
WO (1) WO2019181510A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001072543A (ja) * 1999-09-03 2001-03-21 Daizo:Kk エアゾールフォーム組成物
JP2002309241A (ja) * 2001-04-13 2002-10-23 Daizo:Kk 油中水型エアゾール製品
JP2005350385A (ja) * 2004-06-09 2005-12-22 Mandom Corp 体臭防止剤
JP2007145771A (ja) * 2005-11-29 2007-06-14 Mandom Corp 殺菌剤組成物及びデオドラント剤
JP2009256224A (ja) * 2008-04-14 2009-11-05 Daizo:Kk エアゾール組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101485616B (zh) * 2008-01-17 2012-09-05 花王株式会社 清脆乳液

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001072543A (ja) * 1999-09-03 2001-03-21 Daizo:Kk エアゾールフォーム組成物
JP2002309241A (ja) * 2001-04-13 2002-10-23 Daizo:Kk 油中水型エアゾール製品
JP2005350385A (ja) * 2004-06-09 2005-12-22 Mandom Corp 体臭防止剤
JP2007145771A (ja) * 2005-11-29 2007-06-14 Mandom Corp 殺菌剤組成物及びデオドラント剤
JP2009256224A (ja) * 2008-04-14 2009-11-05 Daizo:Kk エアゾール組成物

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