JPWO2019181510A1 - エアゾール製品 - Google Patents
エアゾール製品 Download PDFInfo
- Publication number
- JPWO2019181510A1 JPWO2019181510A1 JP2020508170A JP2020508170A JPWO2019181510A1 JP WO2019181510 A1 JPWO2019181510 A1 JP WO2019181510A1 JP 2020508170 A JP2020508170 A JP 2020508170A JP 2020508170 A JP2020508170 A JP 2020508170A JP WO2019181510 A1 JPWO2019181510 A1 JP WO2019181510A1
- Authority
- JP
- Japan
- Prior art keywords
- component
- mass
- stock solution
- aerosol product
- propellant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000000443 aerosol Substances 0.000 title claims abstract description 44
- 102000016943 Muramidase Human genes 0.000 claims abstract description 41
- 108010014251 Muramidase Proteins 0.000 claims abstract description 41
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 41
- 239000004325 lysozyme Substances 0.000 claims abstract description 41
- 229960000274 lysozyme Drugs 0.000 claims abstract description 41
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 41
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 38
- 239000011550 stock solution Substances 0.000 claims abstract description 31
- 239000003380 propellant Substances 0.000 claims abstract description 29
- 239000003915 liquefied petroleum gas Substances 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000002781 deodorant agent Substances 0.000 abstract description 9
- -1 alkyl glucoside Chemical class 0.000 description 44
- 239000000047 product Substances 0.000 description 38
- 235000014113 dietary fatty acids Nutrition 0.000 description 16
- 239000000194 fatty acid Substances 0.000 description 16
- 229930195729 fatty acid Natural products 0.000 description 16
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 14
- 125000006353 oxyethylene group Chemical group 0.000 description 13
- 239000000203 mixture Substances 0.000 description 12
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 10
- 239000007789 gas Substances 0.000 description 8
- 239000002202 Polyethylene glycol Substances 0.000 description 7
- 150000005215 alkyl ethers Chemical class 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- 238000005336 cracking Methods 0.000 description 6
- 235000019645 odor Nutrition 0.000 description 6
- 125000005702 oxyalkylene group Chemical group 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 5
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- UYZQWKKNVBJVOF-UHFFFAOYSA-N 1-decoxytetradecane Chemical compound CCCCCCCCCCCCCCOCCCCCCCCCC UYZQWKKNVBJVOF-UHFFFAOYSA-N 0.000 description 3
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- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 3
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- 238000004519 manufacturing process Methods 0.000 description 3
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- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 3
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 3
- ZNVKGUVDRSSWHV-UHFFFAOYSA-L zinc;4-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=C(S([O-])(=O)=O)C=C1.OC1=CC=C(S([O-])(=O)=O)C=C1 ZNVKGUVDRSSWHV-UHFFFAOYSA-L 0.000 description 3
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 2
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 2
- 208000035985 Body Odor Diseases 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
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- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004147 Sorbitan trioleate Substances 0.000 description 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- CMPDPBDUZTUXAD-UHFFFAOYSA-N [3-hydroxy-2-(16-methylheptadecanoyloxy)propyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCC(C)C CMPDPBDUZTUXAD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
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- 238000007796 conventional method Methods 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
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- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 229940074045 glyceryl distearate Drugs 0.000 description 2
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- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 2
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- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- PAFJZWHXMSQJKV-UQZRNVAESA-N (3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol;octadecanoic acid Chemical compound OC[C@@H](O)C1OC[C@H](O)[C@H]1O.OC[C@@H](O)C1OC[C@H](O)[C@H]1O.OC[C@@H](O)C1OC[C@H](O)[C@H]1O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O PAFJZWHXMSQJKV-UQZRNVAESA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 description 1
- ZXNAIPHYBVMMPY-KTKRTIGZSA-N 1-erucoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(=O)OCC(O)CO ZXNAIPHYBVMMPY-KTKRTIGZSA-N 0.000 description 1
- QHZLMUACJMDIAE-SFHVURJKSA-N 1-hexadecanoyl-sn-glycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)CO QHZLMUACJMDIAE-SFHVURJKSA-N 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
- MUHFRORXWCGZGE-KTKRTIGZSA-N 2-hydroxyethyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCO MUHFRORXWCGZGE-KTKRTIGZSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- ZVTDEEBSWIQAFJ-KHPPLWFESA-N 2-hydroxypropyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C)O ZVTDEEBSWIQAFJ-KHPPLWFESA-N 0.000 description 1
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- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
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- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001816 polyoxyethylene sorbitan tristearate Substances 0.000 description 1
- 235000010988 polyoxyethylene sorbitan tristearate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 229940026235 propylene glycol monolaurate Drugs 0.000 description 1
- 229940093625 propylene glycol monostearate Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 description 1
- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N sec-butylidene Natural products CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
前記原液が、下記成分A、成分B及び成分Cを含有し、前記噴射剤が液化石油ガスを含有する、エアゾール製品に関する。
成分A:塩化リゾチーム
成分B:非イオン性界面活性剤
成分C:水
本発明のエアゾール製品における原液は、成分A:塩化リゾチーム、成分B:非イオン性界面活性剤、及び成分C:水を必須成分として含有する。本発明のエアゾール製品は、前記必須成分に加えて、成分D:エタノールをさらに含有することが好ましい。また、成分A〜成分D以外の成分(その他の成分)をさらに含有してもよい。成分A〜成分Dやその他の成分は、それぞれ、1種のみを用いてもよく、2種以上を用いてもよい。
本発明のエアゾール製品における噴射剤は、液化石油ガスを含有する。液化石油ガスとしては特に限定されず、エアゾール製品に使用される液化石油ガスを採用することができ、例えば、プロパン、ノルマルブタン、イソブタンおよびイソペンタンからなる群から選ばれる1種の液化ガス、あるいは2種以上の液化ガスの混合ガスとすることができる。
本発明のエアゾール製品における、原液と噴射剤との質量比(原液/噴射剤)は、液化石油ガスと原液との乳化をしやすくする観点から、好ましくは20/80以上であり、より好ましくは30/70以上である。一方、噴射の勢いを確保する観点、使用時に爽快感を与える観点、液化石油ガスによる冷却感を向上させる観点あるいは原液を最後まで噴射させる観点から、95/5以下が好ましく、92/8以下がより好ましい。
表1及び表2に記した組成からなる原液をエアゾール容器(φ35mm×105mm、アルミ缶、容器満注量:91mL)に充填し、エアゾールバルブを該容器にクリンチした。次いで、噴射剤(液化石油ガス又はジメチルエーテル)を、原液に対して表1及び表2の質量部となるようにステムより充填し、適したスパウトを装着してエアゾール製品を製造した。なお、エアゾール容器に充填した原液と噴射剤の合計量は、いずれの実施例及び比較例においても40gであった。
塩化リゾチーム:キユーピー社製、商品名「塩化リゾチーム」
POEPOPデシルテトラデシルエーテル:日光ケミカルズ社製、商品名「Nikkol PEN−4630」、オキシエチレン基の平均付加モル数:30、オキシプロピレン基の平均付加モル数:6
ポリオキシエチレンセチルエーテル:日光ケミカルズ社製、商品名「Nikkol BC−40」、オキシエチレン基の平均付加モル数:40
ポリオキシエチレン硬化ヒマシ油:日本エマルジョン社製、商品名「EMALEX HC−50」、オキシエチレン基の平均付加モル数:50
モノステアリン酸ポリオキシエチレンソルビタン:花王社製、商品名「レオドール TW−S120V」、オキシエチレン基の平均付加モル数:20
モノラウリン酸ポリエチレングリコール:花王社製、商品名「エマノーン 1112」、オキシエチレン基の平均付加モル数:12
IPMP:大阪化成社製、商品名「イソプロピルメチルフェノール」
液化石油ガス:20℃における蒸気圧0.29MPa
製造直後の試験用エアゾール製品の吐出物中の塩化リゾチームの力価(mg(力価)/mg)を初期値として、40℃で表1及び表2に示す期間保存した後の試験用エアゾール製品の吐出物中の塩化リゾチームの力価(mg(力価)/mg)を試験値として測定した。測定された初期値及び試験値から残存率(%)を算出した。表1及び表2では残存率が90%以上の場合を「A」とし、90%未満の場合を「B」とした。
すなわち、各試験用エアゾール製品のステムから吐出物を吐出させ、得られた吐出物に対して超音波処理することで残存する噴射剤を揮散させたものを試料サンプルとし、得られた試料サンプルをpH6.2リン酸塩緩衝液で適宜希釈したものを、試料溶液とした。35℃の水浴中で加温した3mLの試料溶液を、あらかじめ35℃の水浴中で加温した3mLのpH6.2リン酸塩緩衝液と3mLの塩化リゾチーム用基質溶液(Micrococcus lysodeikticusをpH6.2のリン酸塩緩衝液で懸濁し、640nmの波長での透過率を10%とした懸濁液)との混合溶液に加えた後、35℃で正確に10分間反応させ、吸光度の減少を塩化リゾチーム標準溶液(定量した塩化リゾチーム標準品をpH3.0の塩酸溶液で希釈した溶液)による減少と比較することで定量した。
(原液)
塩化リゾチーム 0.40
イソプロピルメチルフェノール 0.20
パラフェノールスルホン酸亜鉛 0.20
POEPOPデシルテトラデシルエーテル 0.60
エタノール 20.00
香料 0.30
精製水 78.30
合計 100.00(質量%)
(噴射剤)
液化石油ガス 100.00
合計 100.00(質量%)
原液:噴射剤=70:30(質量比)
(原液)
塩化リゾチーム 0.15
イソプロピルメチルフェノール 0.15
パラフェノールスルホン酸亜鉛 0.40
POEPOPデシルテトラデシルエーテル 0.80
エタノール 22.00
メントール 0.20
精製水 76.30
合計 100.00(質量%)
(噴射剤)
液化石油ガス 100.00
合計 100.00(質量%)
原液:噴射剤=50:50(質量比)
Claims (4)
- 原液と噴射剤とが容器本体に充填されたエアゾール製品であって、
前記原液が、下記成分A、成分B及び成分Cを含有し、前記噴射剤が液化石油ガスを含有する、エアゾール製品。
成分A:塩化リゾチーム
成分B:非イオン性界面活性剤
成分C:水 - 前記原液が下記成分Dをさらに含有し、前記原液100質量%中、成分Dの含有量が30.0質量%以下である、請求項1に記載のエアゾール製品。
成分D:エタノール - 前記原液100質量%中、成分Aの含有量が0.1質量%以上、1.5質量%以下である、請求項1又は2に記載のエアゾール製品。
- 前記原液100質量%中、成分Bの含有量が0.05質量%以上、1.5質量%以下である、請求項1〜3のいずれか一項に記載のエアゾール製品。
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JP2018050950 | 2018-03-19 | ||
JP2018050950 | 2018-03-19 | ||
PCT/JP2019/008878 WO2019181510A1 (ja) | 2018-03-19 | 2019-03-06 | エアゾール製品 |
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WO (1) | WO2019181510A1 (ja) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001072543A (ja) * | 1999-09-03 | 2001-03-21 | Daizo:Kk | エアゾールフォーム組成物 |
JP2002309241A (ja) * | 2001-04-13 | 2002-10-23 | Daizo:Kk | 油中水型エアゾール製品 |
JP2005350385A (ja) * | 2004-06-09 | 2005-12-22 | Mandom Corp | 体臭防止剤 |
JP2007145771A (ja) * | 2005-11-29 | 2007-06-14 | Mandom Corp | 殺菌剤組成物及びデオドラント剤 |
JP2009191064A (ja) * | 2008-01-17 | 2009-08-27 | Kao Corp | クラッキングローション |
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Publication number | Priority date | Publication date | Assignee | Title |
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JP5507818B2 (ja) * | 2008-04-14 | 2014-05-28 | 株式会社ダイゾー | エアゾール組成物 |
-
2019
- 2019-03-06 WO PCT/JP2019/008878 patent/WO2019181510A1/ja active Application Filing
- 2019-03-06 JP JP2020508170A patent/JPWO2019181510A1/ja not_active Ceased
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001072543A (ja) * | 1999-09-03 | 2001-03-21 | Daizo:Kk | エアゾールフォーム組成物 |
JP2002309241A (ja) * | 2001-04-13 | 2002-10-23 | Daizo:Kk | 油中水型エアゾール製品 |
JP2005350385A (ja) * | 2004-06-09 | 2005-12-22 | Mandom Corp | 体臭防止剤 |
JP2007145771A (ja) * | 2005-11-29 | 2007-06-14 | Mandom Corp | 殺菌剤組成物及びデオドラント剤 |
JP2009191064A (ja) * | 2008-01-17 | 2009-08-27 | Kao Corp | クラッキングローション |
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