JP3905512B2 - エアゾール組成物 - Google Patents
エアゾール組成物 Download PDFInfo
- Publication number
- JP3905512B2 JP3905512B2 JP2003422293A JP2003422293A JP3905512B2 JP 3905512 B2 JP3905512 B2 JP 3905512B2 JP 2003422293 A JP2003422293 A JP 2003422293A JP 2003422293 A JP2003422293 A JP 2003422293A JP 3905512 B2 JP3905512 B2 JP 3905512B2
- Authority
- JP
- Japan
- Prior art keywords
- stock solution
- urea
- propellant
- aerosol composition
- aerosol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000001569 carbon dioxide Substances 0.000 claims description 18
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- 230000000087 stabilizing effect Effects 0.000 claims description 3
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- 230000003020 moisturizing effect Effects 0.000 description 16
- -1 and the like Chemical class 0.000 description 15
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Landscapes
- Medicinal Preparation (AREA)
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Description
しかしながら、これらの組成物においても、尿素の安定化は未だ十分ではなかった。
また、本発明は、原液中に尿素1〜20質量%及び水10〜90質量%を含有する原液と、炭酸ガスを50容積%(25℃)以上含む噴射剤を、容積比率(25℃)で原液:噴射剤=1:50〜1:3の割合で混合することによる尿素の安定化方法を提供するものである。
尿素は、原液中に1〜20質量%、好ましくは1〜10質量%含有される。原液中に1質量%以上の尿素を含有させることにより、保湿効果、角質軟化効果及び鎮痒効果、特に優れた保湿効果を得ることができる。また、20質量%以下であれば、特に優れた安定性が得られる。
原液中のpH調整剤の含有量は、原液のpHのみならず、原液と噴射剤を混合した後の組成物のpHの関係により調整することができ、尿素に対してモル当量比で1〜10%、好ましくは3〜10%である。この範囲内であれば、原液のpHと噴射剤を混合したときのpHの変化量を小さくすることができ、粘度変化や乳化状態劣化などの組成物の状態変化を抑えることができる。
多価アルコールとしては、例えば、エチレングリコール、プロピレングリコール、1,3−ブチレングリコール、ジエチレングリコール、ジプロピレングリコール、トリエチレングリコール、ヘキシレングリコール、ポリエチレングリコール、エトキシジグリコール、グリセリン等が挙げられる。これらのうち、保湿効果の点から、特に、プロピレングリコール、1,3−ブチレングリコール、ジプロピレングリコール、ポリエチレングリコール、エトキシジグリコール、グリセリンが好ましい。
多価アルコールは1種以上を用いることができ、原液中に1〜20質量%、特に3〜20質量%含有させるのが好ましい。
かかる成分としては、例えば、エタノール、プロパノール、イソプロパノール等の炭素数1〜3の直鎖又は分岐鎖の低級アルコールを挙げることができる。低級アルコールを配合すると、エアゾール組成物を皮膚に塗布した際、気化熱によって皮膚に冷却感を与え、爽快感を与えることができる。また、低級アルコールは、原液中の水と噴射剤との相溶性を高め、エアゾール組成物を均質化するのにも有効である。低級アルコールとしては、製剤安定性の面から、特に、エタノール、イソプロパノールが好ましい。低級アルコールは1種以上を用いることができ、原液中に0.1〜10質量%、特に0.1〜5質量%含有させるのが好ましい。
炭酸ガスとともに用いられる噴射剤としては、例えば、液化石油ガス(エタン、プロパン、エチレン、イソブタン、ノルマルブタン、プロピレン等、これらの混合ガス(例えば、イソブタンとプロパン、プロパンとブタンの混合ガス等))、エーテル系噴射剤(ジメチルエーテル等)、フロロカーボン(フロロカーボン、クロロフロロカーボン、ブロモクロロフロロカーボン等)、圧縮ガス(窒素、空気、これらの混合ガス等)、フロンガス(モノクロロジフルオロエタン、テトラフルオロエタン等)が挙げられ、1種以上を用いることができる。特に、窒素、ジメチルエーテル、液化石油ガスが好ましい。
噴射剤が混合物である場合には、炭酸ガス:他の噴射剤の混合比率(容積比)は、気体状態(1気圧、25℃)で10:0〜5:5であるのが好ましい。
特に、尿素の効果である保湿効果、角質軟化効果又は鎮痒効果を有するエアゾール剤、具体的には、エアゾール剤形態の化粧料又は洗浄料、エアゾール剤の形態を有する鎮痒製剤、保湿製剤、角質軟化製剤などとして好適である。
表1に示す処方に従い、常法により、原液成分を混合して原液を製造し、次いでこの原液と噴射剤を所定の割合でエアゾール缶に充填して、エアゾール組成物を得た。製造直後及び45℃の恒温槽で1ヶ月間保存した後において、組成物の臭い、しっとり感及びpHを評価した。結果を表1に併せて示す。
(1)臭い:
エアゾール組成物を、容器から噴射したとき、噴射された液のにおいを直接嗅ぎ、その臭いを、臭い(0点)/臭くない(1点)で評価した。5名の専門パネラーによって評価した合計の点数を示す。
エアゾール組成物を肌上に噴射し、肌になじませるように伸ばした際に感じるしっとり感を、しっとりする(2点)/ややしっとりする(1点)/しっとりしない(0点)で評価した。5名の専門パネラーによって評価した合計の点数を示す。
Claims (4)
- 原液中に尿素1〜20質量%、尿素に対してモル当量比で1〜10%のpH調整剤及び水10〜90質量%を含有する原液と、炭酸ガスとを含有し、製造時のpHが5〜8(25℃)であるエアゾール組成物。
- 原液中に、多価アルコールを1〜20質量%含有する請求項1記載のエアゾール組成物。
- 原液中に、尿素を1〜10質量%含有する請求項1又は2記載のエアゾール組成物。
- 原液中に尿素1〜20質量%及び水10〜90質量%を含有する原液と、炭酸ガスを50容積%(25℃)以上含む噴射剤を、容積比率(25℃)で原液:噴射剤=1:50〜1:3の割合で混合することによる尿素の安定化方法。
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JP2018012707A (ja) * | 2017-08-12 | 2018-01-25 | 株式会社 Mtg | 噴霧装置用化粧料 |
WO2022230853A1 (ja) * | 2021-04-28 | 2022-11-03 | 花王株式会社 | エアゾール化粧料 |
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