WO2019117216A1 - Produit générateur d'aérosol de type pulvérisateur doseur et procédé d'utilisation de produit générateur d'aérosol de type pulvérisateur doseur - Google Patents

Produit générateur d'aérosol de type pulvérisateur doseur et procédé d'utilisation de produit générateur d'aérosol de type pulvérisateur doseur Download PDF

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Publication number
WO2019117216A1
WO2019117216A1 PCT/JP2018/045763 JP2018045763W WO2019117216A1 WO 2019117216 A1 WO2019117216 A1 WO 2019117216A1 JP 2018045763 W JP2018045763 W JP 2018045763W WO 2019117216 A1 WO2019117216 A1 WO 2019117216A1
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WIPO (PCT)
Prior art keywords
injection
aerosol
noise level
aerosol product
valve
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PCT/JP2018/045763
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English (en)
Japanese (ja)
Inventor
健二 延原
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アース製薬株式会社
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Application filed by アース製薬株式会社 filed Critical アース製薬株式会社
Priority to JP2019559182A priority Critical patent/JP7328897B2/ja
Publication of WO2019117216A1 publication Critical patent/WO2019117216A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B9/00—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour
    • B05B9/03—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material
    • B05B9/04—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/44—Valves specially adapted therefor; Regulating devices
    • B65D83/52—Valves specially adapted therefor; Regulating devices for metering

Definitions

  • the present invention relates to metered dose aerosol products and methods of using metered dose aerosol products. More particularly, the present invention relates to a metered-dose aerosol product and a method of using the metered-dose aerosol product, wherein the user can realize that the aerosol composition is sufficiently jetted at the time of jetting and the excessive use can be suppressed. .
  • the constant injection type aerosol products in circulation have a small discharge amount per one time (for example, preferably about 0.2 to 0.9 mL) (see, for example, Patent Document 1). Therefore, the size of the aerosol product can be reduced, which is easy and convenient.
  • the present invention has been made in view of such conventional problems, and the user can realize that the aerosol composition is sufficiently injected at the time of injection, and a quantitative injection type aerosol product that can prevent excessive use, and It is an object of the present invention to provide a method of using a metered dose aerosol product.
  • the present inventor pays attention to a time average value (equivalent noise level) of noise that fluctuates in a predetermined time (for example, 10 seconds) after injection, and such equivalent noise level is above a certain level.
  • a time average value equivalent noise level
  • the present inventors have found that the user can realize that the aerosol composition has been sufficiently injected at the time of injection, whereby the appropriate number of times can be injected and overuse can be suppressed, thus completing the present invention.
  • the jet amount is adjusted to a specific range to achieve the above noise level range.
  • the present invention has been accomplished by finding that the above problems can be solved.
  • the usage method of the fixed injection type aerosol product of this invention which solves the said subject uses the said fixed injection type aerosol product,
  • the equivalent noise level of 10 seconds of the injection sound in A characteristic in a common noise meter is 62 dB or more
  • a method of using the metered-dose aerosol product that generates a jet noise so that
  • the user can realize that the aerosol composition is sufficiently sprayed at the time of spraying, the drug, the solvent, and the like due to excessive use are not excessively dispersed in the environment, and a desired effect is obtained. It is possible to provide a metered dose aerosol product that can be used and a method of using the metered dose aerosol product.
  • the metered-dose aerosol product (hereinafter, also simply referred to as an aerosol product) according to one embodiment of the present invention is an aerosol container filled with an aerosol composition containing a stock solution and a propellant, and a metered-dose aerosol attached to the aerosol container.
  • a valve hereinafter, also simply referred to as an aerosol valve
  • the aerosol product has an injection amount of 1 to 3 mL per time, and an equivalent noise level of 10 seconds of the injection noise at the A characteristic in the ordinary noise level meter is 62 dB or more. Each of these will be described below.
  • the following description is an illustration, and an aerosol container, an aerosol valve, and the injection member may be suitably design-changed.
  • the aerosol container is a pressure-resistant container for pressure-filling the aerosol composition.
  • An aerosol container is a substantially cylindrical container in which the space where an aerosol composition is filled is formed.
  • An opening is provided at the top of the aerosol container. The opening is sealed by an aerosol valve described later.
  • the material of the aerosol container is not particularly limited.
  • the aerosol container may be made of various metals, resin, glass, etc. having pressure resistance.
  • Aerosol composition is the content of an aerosol product and comprises a stock solution and a propellant.
  • Undiluted solution is a component which can constitute an aerosol composition with a propellant.
  • the stock solution is loaded into the aerosol container when the aerosol composition is prepared.
  • the stock solution can contain the active ingredient.
  • the active ingredient is, for example, an insecticidal ingredient, a bactericidal ingredient (antifungal ingredient), a deodorizing ingredient, an aromatic ingredient and the like.
  • insecticidal component is not particularly limited.
  • An insecticidal component can be suitably selected according to the kind of object pest.
  • the insecticidal component include pyrethroid compounds such as pyrethrin, allethrin, phthalthrin, resmethrin, phenmethrin, permethrin, empentrin, cifenothrin, imifurothrin, transfluthrin, metfluthrin, cyfluthrin, profluthrin, fenitrothion, dichlorvos, chlorpyrifos methylmethyl, etc.
  • organophosphorus compounds such as diazinon and fenthion; carbamate compounds such as carbaryl and propoxur; and insecticidal compounds such as methoprene, pyriproxyfen, methoxadiazon, fipronil, amidoflumetho and the like.
  • the above insecticidal component may be used in combination of two or more insecticidal components.
  • bactericidal component antifungal component
  • examples of the bactericidal component include isopropylmethylphenol, triclosan, thymol, alkyldiaminoethylglycine hydrochloride, silver ion and the like.
  • the type of the deodorant component is not particularly limited.
  • Deodorizing components are, for example, lauryl methacrylate, tea extract, plant polyphenols and the like.
  • the content of the active ingredient may be a content that exhibits the effect of the active ingredient (for example, in the case of an insecticidal ingredient, an insecticidal effect (such as a knockdown effect)), the content of the active ingredient
  • the upper limit of is not particularly limited.
  • the content of the active ingredient is not particularly limited.
  • the content is preferably 0.01% by weight / volume (w / v%) or more in the aerosol composition, for example, 0.1% by weight / volume% (w / v) % Or more is more preferable.
  • the content of the pesticidal ingredient is preferably 0.01% by weight / volume% (w / v%) or more in the aerosol composition, and 0.1% by weight / volume% It is more preferable that it is (w / v%) or more. With the above amount, sufficient insecticidal effect can be obtained.
  • the stock solution may contain a solvent.
  • a solvent is suitably contained, for example, in order to mix
  • the solvent may be lower alcohol such as ethanol and isopropanol, polyhydric alcohol such as glycerin and ethylene glycol, linear, branched or cyclic paraffins, petroleum oils such as kerosene, water; isopropyl myristate, laurin Esters such as hexyl acid;
  • the content of the solvent is preferably 0.5 parts by mass or more, and more preferably 1 part by mass or more with respect to 1 part by mass of the active ingredient.
  • the content of the solvent is preferably 1000 parts by mass or less, and more preferably 500 parts by mass or less with respect to 1 part by mass of the active ingredient. If it is in the said range, a stock solution will be easy to mix
  • the stock solution contains, in addition to the above active ingredients, nonionic, anionic or cationic surfactants, antioxidants such as butylhydroxytoluene; stabilizers such as citric acid and ascorbic acid; inorganic powders such as talc and silicic acid Arbitrary components, such as a fragrance
  • nonionic, anionic or cationic surfactants such as butylhydroxytoluene
  • stabilizers such as citric acid and ascorbic acid
  • inorganic powders such as talc and silicic acid
  • dye, may be contained suitably.
  • the propellant is a medium for injecting the stock solution, and is pressure-filled into the aerosol container together with the stock solution.
  • the propellant is not particularly limited.
  • the propellant is hydrofluoroolefin, dimethyl ether (DME), liquefied petroleum gas (LPG) and the like.
  • DME dimethyl ether
  • LPG liquefied petroleum gas
  • the above-mentioned propellant may be used combining two or more propellants.
  • hydrofluoroolefin is exemplified by hydrofluoropropene.
  • hydrofluoropropene is 1,3,3,3-tetrafluoropropene, 2,3,3,3-tetrafluoropropene, 2,3,3-trifluoropropene, 3,3,3- Examples are trifluoropropene, 1-chloro-3,3,3-trifluoropropene and the like.
  • 1-chloro-3,3,3-trifluoropropene include (E) -1-chloro-3,3,3-trifluoropropene and the like.
  • compressed gas such as carbon dioxide gas, nitrogen gas, compressed air, oxygen gas, etc. may be used in combination to adjust the pressure of the aerosol composition. .
  • the blending ratio (volume ratio) of the undiluted solution of the aerosol composition and the propellant is preferably 1:99 to 25:75, more preferably 3:97 to 25:75, 3:97 to 20:80. It is further preferred that With such a volume ratio, the aerosol product can be easily adjusted so that the equivalent noise level for 10 seconds of the jet noise at the time of discharge is 62 dB or more, and as a result, the aerosol composition is sufficiently jetted at the time of jet The user can realize that he is
  • the aerosol valve is a mechanism for taking out the aerosol composition filled in the aerosol container, and closes the opening of the aerosol container. Moreover, the aerosol valve of this embodiment is provided with a metering chamber for temporarily storing the aerosol composition taken out of the aerosol container. The volume of the metering chamber corresponds to the volume of the aerosol composition sprayed by one injection. The volume of the metering chamber of this embodiment is 1 to 3 mL.
  • the aerosol valve includes an opening and closing member for switching communication between the inside and the outside of the metering chamber of the aerosol valve by switching the injection member by the user, a housing to which the opening and closing member is attached, and A mounting member is provided for holding in place.
  • the opening and closing member includes a stem that slides up and down in conjunction with the injection member. The sliding of the stem switches the communication (injection state) and shutoff (non-injection state) of the aerosol composition.
  • the aerosol valve is formed with a housing bore for taking in the aerosol composition from the aerosol container and a stem bore for delivering the taken-in aerosol composition to the spray member.
  • the housing hole is formed in the housing.
  • the stem hole is formed in the stem. The path from the housing bore to the stem bore constitutes an internal passage through which the aerosol composition passes.
  • the stem is a site attached to the aerosol valve, and an internal passage is formed for delivering the aerosol composition taken into the aerosol valve to the injection button.
  • the internal passage is suitably opened and closed by a stem rubber.
  • the internal pressure of the aerosol valve at 25 ° C. is preferably 0.3 MPa or more, more preferably 0.4 MPa or more, in the state of being filled with the stock solution and the propellant. Further, the internal pressure of the aerosol valve at 25 ° C. is preferably 0.7 MPa or less, and more preferably 0.6 MPa or less.
  • the internal pressure of an aerosol valve is less than 0.3 Mpa, an aerosol product tends to become small in a jet noise, and it is hard to be realized by a user.
  • the internal pressure of the aerosol valve is less than 0.3 MPa, the aerosol composition may drip from the injection port after the injection.
  • the internal pressure of the aerosol valve exceeds 0.7 MPa, the aerosol composition may leak from the aerosol container.
  • the internal pressure of the aerosol valve is, for example, PGM-10KE compact pressure sensor (manufactured by Kyowa Electric Industry) attached to a WGA-710C instrumentation conditioner (manufactured by Kyowa Electric Industry) at 25 ° C as the aerosol valve. It can measure by connecting.
  • the injection member is a member for injecting the stock solution taken from the aerosol container together with the propellant.
  • the injection member is provided with an injection hole for injecting the aerosol composition.
  • the number, size, shape, and cross-sectional area of the injection ports can be appropriately selected as needed so that the equivalent noise level (L Aeq ) described later is 62 dB or more. Therefore, the aerosol product of the present embodiment may employ an injection member in which various injection holes are formed in a range where the equivalent noise level (L Aeq ) is 62 dB or more.
  • the number, size and shape of the injection ports are not particularly limited. As an example, the number of injection holes may be one, or two or more. Further, the size of the injection port (injection port diameter) is preferably 0.2 mm or more, more preferably 0.3 mm or more, and still more preferably 0.5 mm or more. The diameter of the injection port is preferably 4.5 mm or less, more preferably 3.5 mm or less, and still more preferably 2.5 mm or less.
  • the shape (cross-sectional shape) of the injection port may be circular, oval, square, or various irregular shapes.
  • the total cross-sectional area (total opening area) of the injection port is not particularly limited.
  • the total cross-sectional area is appropriately adjusted as necessary so that the equivalent noise level (L Aeq ) described later is 62 dB or more.
  • the total cross-sectional area is preferably 0.2 mm 2 or more, and more preferably 0.3 mm 2 or more.
  • the total cross-sectional area is preferably 4.0 mm 2 or less, more preferably 3.5 mm 2 or less.
  • the “total cross-sectional area” is the total area of the cross-sectional area (opening area) of the injection port. That is, when there is one injection port, the total cross-sectional area is the cross-sectional area of the injection port itself, and when there are two or more injection ports, the total cross-sectional area is the sum of the cross-sectional areas of all the injection ports.
  • the length of the injection passage in the injection member is not particularly limited.
  • the length of the injection passage is appropriately adjusted as necessary so that the equivalent noise level (L Aeq ) described later is 62 dB or more.
  • the length of the injection passage is preferably 10 mm or more.
  • the length of the injection passage is preferably 50 mm or less, and more preferably 40 mm or less.
  • “the length of the injection passage” is the length from the tip of the stem to the injection port.
  • the stem mechanism and the aerosol valve are operated, and the metering chamber of the aerosol valve communicates with the outside.
  • a predetermined amount of the aerosol composition in the metering chamber of the aerosol valve is taken out according to the pressure difference between the metering chamber of the aerosol valve and the outside, and is jetted from the injection port of the injection member.
  • the aerosol product of this embodiment is adjusted so that the injection amount per injection is 1 to 3 mL.
  • the injection amount per injection may be 1.0 mL or more.
  • the injection amount per injection may be 3.0 mL or less, preferably 2.5 mL or less.
  • the injection amount per injection is less than 1.0 mL, the jetted aerosol composition tends to have a low jet noise and is hard to be perceived by the user.
  • the injection amount per time exceeds 3.0 mL, the aerosol product tends to make it difficult to design a metering chamber.
  • the aerosol product of the present embodiment has an equivalent noise level (L Aeq ) of 10 seconds for the jet noise at the A characteristic in the ordinary noise level meter at 62 dB or more.
  • the equivalent noise level (L Aeq ) may be adjusted to be 62 dB or more, preferably 64 dB or more, and more preferably 67 dB or more.
  • the upper limit of the equivalent noise level (L Aeq ) is not particularly limited. From the viewpoint of noise during injection, the equivalent noise level (L Aeq ) is preferably 90 dB or less. When the equivalent noise level (L Aeq ) is 62 dB or more, the user can realize that the aerosol composition is sufficiently injected.
  • the equivalent noise level (L Aeq ) is a numerical value for quantitatively grasping the noise level in the case of temporal variation, and based on JIS Z8731-1999, within a certain measurement time (in the present embodiment) It is defined as the noise level of a continuous steady sound giving an average squared sound pressure equal to the average squared sound pressure of fluctuating noise in 10 seconds). The smaller the value of the equivalent noise level (L Aeq ), the less noise and the quieter. Also, the A-characteristic refers to a frequency-weighting characteristic in consideration of human hearing used in measurement by a sound level meter.
  • the equivalent noise level (L Aeq ) of the present embodiment is measured , for example, with an A characteristic from a distance of 10 cm just beside the injection hole of the aerosol product with a normal sound level meter NL-21 (manufactured by Rion Co., Ltd.). It can be calculated. Further, the equivalent noise level (L Aeq ) in the present embodiment is a noise level when the background equivalent noise level (L Aeq ) is 36 dB.
  • the aerosol product of the present embodiment achieves the above-mentioned equivalent noise level (L Aeq ), so that it is usually used (for example, a quiet living room etc. The background in this case is about 35 to 37 dB) ), It can be realized that the user is using it.
  • the difference between the equivalent noise level (L Aeq ) and the background noise level is preferably 15 dB or more, and more preferably 20 dB or more.
  • the difference between the equivalent noise level (L Aeq ) and the background noise level is 15 dB or more, the user can realize that the aerosol composition is sufficiently jetted regardless of the place of use.
  • the maximum noise level (L Amax ) of the injection noise in the A characteristic of the ordinary noise level meter is preferably 78 dB or more, and more preferably 80 dB or more.
  • the upper limit of the maximum noise level (L Amax ) is not particularly limited. From the viewpoint of noise during injection, the maximum noise level (L Amax ) is preferably 100 dB or less.
  • the maximum noise level (L Amax ) represents the maximum value of the noise level within the measurement time.
  • the maximum noise level (L Amax ) of the present embodiment is measured, for example, with an A characteristic from a distance of 10 cm just beside the injection hole of the aerosol product with a normal sound level meter NL-21 (manufactured by Rion Co., Ltd.). It can be calculated. Further, the maximum noise level (L Amax ) in the present embodiment is the noise level when the background maximum noise level (L Amax ) is 36.8 dB.
  • the mixing ratio of the above-mentioned undiluted solution and propellant is specified, the injection amount per time is adjusted to be 1 to 3 mL, and the A characteristic in the ordinary noise level meter
  • the equivalent noise level (L Aeq ) of 10 seconds of the jet noise is 62 dB or more, the user can realize that the aerosol composition is sufficiently jetted.
  • the method of adjusting the injection amount per injection within the above range or the method of adjusting the equivalent noise level (L Aeq ).
  • the equivalent noise level (L Aeq ) can be adjusted by adjusting the internal pressure of the aerosol valve at 25 ° C, adjusting the mixture ratio of the undiluted solution and the propellant, in addition to the method of adjusting the injection amount per one time. Adjustment can be made as appropriate by adjusting the number, size, shape and the like of the ejection members.
  • an aerosol product may be produced by filling the aerosol container with the undiluted solution, closing the opening of the aerosol container by means of the aerosol valve, and pressure filling the propellant through the orifice or stem of the injection member. it can.
  • the amount of injection per injection and the equivalent noise level (L Aeq ) are adjusted within a predetermined range, so that the aerosol composition is sufficiently injected at the time of injection. The user can realize that it is possible to prevent overuse.
  • the method of using the metered- dose aerosol product uses the above-described metered- dose aerosol product to determine the 10-second equivalent noise level ( LAeq ) of the jet noise at the A characteristic in a common sound level meter.
  • This is a method of generating an injection sound so as to be 62 dB or more. According to such a method, the user can realize that the aerosol composition has been sufficiently injected at the time of injection, and the excessive use can be suppressed.
  • the equivalent noise level (L Aeq ) when the method of using the fixed injection type aerosol product of this embodiment is implemented is a noise level when the background equivalent noise level (L Aeq ) is 36 dB.
  • Aerosol product 1 injection member (injection diameter ⁇ 0.6 mm, opening area 0.28 mm 2 , injection port with one circular injection nozzle cross-sectional shape, length of injection passage 10.8 mm), aerosol valve (volume of metering chamber 1.) 0 mL)
  • Aerosol product 2 injection member (injection diameter ⁇ 1.0 mm, opening area 0.79 mm 2 , injection port having a circular cross-sectional shape of injection port, injection path length 18.6 mm), aerosol valve (volume of metering chamber 1.
  • Aerosol product 3 injection member (injection diameter ⁇ 1.6 mm, opening area 2.01 mm 2 , injection port having a circular cross-sectional shape of injection port, injection path length 18.6 mm), aerosol valve (volume of metering chamber 1.
  • Aerosol product 4 Injection member (aperture diameter: 2.0 mm, opening area: 3.14 mm 2 , injection port with one circular injection nozzle cross-sectional shape, length of injection passage: 18.6 mm), aerosol valve (volume of metering chamber: 1) 0 mL) Aerosol product 5: Injection member (injection diameter ⁇ 1.8 mm, opening area 2.54 mm 2 , injection port with circular injection nozzle cross section, length of injection passage 36 mm), aerosol valve (volume of measuring chamber 1.0 mL) Aerosol product 6: Injection member (injection diameter ⁇ 1.0 mm, total opening area 2.36 mm 2 , injection port 3 circular injection nozzle cross section shape, injection path length 36 mm), aerosol valve (volume of measuring chamber 1.0 mL ) Aerosol product 7: Injection member (injection diameter ⁇ 0.5 mm, total opening area 1.57 mm 2 , injection port 8 circular injection nozzle cross-sectional shape, length of injection passage 36 mm), aerosol valve (volume of measuring volume of measuring
  • Aerosol product 9 injection member (injection diameter ⁇ 1.0 mm, opening area 0.79 mm 2 , injection port having a circular cross-sectional shape of injection port, injection path length 18.6 mm), aerosol valve (volume of metering chamber 2.
  • Aerosol product 10 injection member (injection diameter ⁇ 1.6 mm, opening area 2.01 mm 2 , injection port having a circular cross-sectional shape of injection port, injection path length 18.6 mm), aerosol valve (volume of metering chamber 2.
  • Aerosol product 11 injection member (injection diameter ⁇ 2.0 mm, opening area 3.14 mm 2 , injection port with one circular injection nozzle cross-sectional shape, length 18.6 mm of injection passage), aerosol valve (volume of metering chamber 2.) 2 mL) Aerosol product 12: Injection member (aperture diameter ⁇ 1.8 mm, opening area 2.54 mm 2 , injection port with one circular injection nozzle cross-sectional shape, length of injection passage 36 mm), aerosol valve (volume of measuring chamber 2.2 mL) Aerosol product 13: Injection member (injection diameter ⁇ 1.0 mm, total opening area 2.36 mm 2 , injection port 3 circular injection nozzle cross section shape, length of injection passage 36 mm), aerosol valve (volume of metering chamber 2.2 mL ) Aerosol product 14: Injection member (injection diameter ⁇ 0.5 mm, total opening area 1.57 mm 2 , injection port 8 circular injection nozzle cross section shape, length of injection passage 36 mm), aerosol valve (volume of
  • Aerosol product 16 injection member (injection diameter ⁇ 1.0 mm, opening area 0.79 mm 2 , injection port with one circular injection nozzle cross-sectional shape, length 18.6 mm of injection passage), aerosol valve (volume of metering chamber: 0. 2 mL) Aerosol product 17: injection member (injection diameter ⁇ 1.6 mm, opening area 2.01 mm 2 , injection port with one circular injection nozzle cross-sectional shape, injection path length 18.6 mm), aerosol valve (volume of metering chamber: 0.
  • Aerosol product 18 injection member (injection diameter ⁇ 2.0 mm, opening area 3.14 mm 2 , injection port having a circular cross-sectional shape of injection port, injection path length 18.6 mm), aerosol valve (volume of metering chamber: 0.
  • Aerosol product 19 Injection member (aperture diameter ⁇ 1.8 mm, opening area 2.54 mm 2 , injection port with one circular injection nozzle cross-sectional shape, length of injection passage 36 mm), aerosol valve (volume of measurement chamber 0.2 mL)
  • Aerosol product 20 injection member (injection diameter ⁇ 1.0 mm, total opening area 2.36 mm 2 , injection port 3 circular injection nozzle cross-sectional shape, length of injection passage 36 mm), aerosol valve (volume of metering chamber 0.2 mL )
  • Aerosol product 21 injection member (injection diameter ⁇ 0.5 mm, total opening area 1.57 mm 2 , injection port 8 circular injection nozzle cross section shape, length of injection passage 36 mm), aerosol valve (volume of metering chamber 0.2 mL )
  • Example 1 Transfluthrin was dissolved in isopropyl alcohol (IPA) to a concentration of 25 w / v% to prepare a stock solution. 100% of the obtained stock solution is filled in an aerosol container with a volume of 287 mL, and after attaching an aerosol valve, the propellant (liquefied so that the blending ratio (volume ratio) of the stock solution and the propellant is 6.4 / 93.6 Oil gas saturated vapor pressure: 0.29 MPa (25 ° C.) was pressure-filled, and the injection member was attached to produce an aerosol product (aerosol valve, aerosol member 7 was used for the injection member).
  • IPA isopropyl alcohol
  • the internal pressure (25 ° C.) of the aerosol valve was 0.36 MPa.
  • the internal pressure of the valve is 25 ° C by connecting the PGM-10 KE compact pressure sensor (Kyowa Electric Co., Ltd.) attached to the WGA-710C instrumentation conditioner (Kyowa Electric Co., Ltd.) to the aerosol valve It was measured.
  • Example 2 Propellant (liquefied petroleum gas saturated steam so that the mixing ratio (volume ratio) of the undiluted solution and the propellant prepared in Example 1 is 6.4 / 93.6, using the aerosol valve 14 and the aerosol product 14 as a spraying member
  • An aerosol product was prepared in the same manner as Example 1, except that the pressure was 0.49 MPa (25 ° C.).
  • Example 1 Example 1 and Example 1 except that the undiluted solution formulation described in Table 2 or Table 3 to be described later, the type and gas pressure of the propellant, the valve internal pressure, and the type of aerosol product used (any of aerosol products 1 to 21) were changed.
  • An aerosol product was prepared by the same method.
  • Each aerosol product can be used in a room of 8 tatami ( 36-dB background noise equivalent level (L Aeq ) as a fixed-injection aerosol containing transfluthrin as an active ingredient) and it can be realized that the air has been sufficiently injected into the room It was injected up to.
  • the aerosol composition was repeatedly jetted to the user who did not get a feeling of use in one jet, and the number of jets until the user felt that the jet was sufficiently jetted into the room was examined. The results are shown in Table 1.
  • the aerosol products of Examples 1, 2, 5, 9, 68 show that in many testers, the aerosol composition is sufficiently injected into the room with one injection. I was able to feel it.
  • some testers required three to four injections to realize that the aerosol composition was sufficiently injected into the room, and were sufficiently injected into the room. The average number of injections to realize that it was two was. From these results, when the equivalent noise level (L Aeq ) is 62 dB or more (Examples 1, 2, 5, 9, 68), the user can realize that the aerosol composition is sufficiently injected. Was shown.
  • Examples 1 to 91, Comparative Examples 1 to 28 An aerosol product was prepared in the same manner as in Example 1 except that the undiluted solution formulation described in Table 1, the type and gas pressure of the propellant, the valve internal pressure, and the type of aerosol product used (aerosol products 1 to 21) were changed.
  • the equivalent noise level (L Aeq ) (dB) and the maximum noise level (L Amax ) (dB) were measured.
  • the results of the equivalent noise level (L Aeq ) (dB) are shown in Table 2.
  • the results of the maximum noise level (L Amax ) (dB) are shown in Table 3.
  • LPG represents liquefied petroleum gas
  • IPA represents isopropyl alcohol
  • IPM isopropyl myristate
  • DME dimethyl ether.
  • the aerosol products of Examples 1 to 91 each have an injection volume of 1.0 to 3.0 mL and an equivalent noise level (L Aeq ) of 62 dB or more. Met. Therefore, the aerosol products of Examples 1 to 91 should be sufficiently sprayed by the tester as described in connection with Table 1, even when using various aerosol compositions and spraying members. Was thought to be able to prevent overuse. Also, these tendencies were similar when referring to the maximum noise level (L Amax ). On the other hand, among the comparative examples 1 to 28, the aerosol products of comparative examples 1, 3, 5 to 8, 10 to 24 and 26 to 28 had an equivalent noise level (L Aeq ) of less than 62 dB, and thus were sufficient by the tester.

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  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Nozzles (AREA)
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Abstract

L'invention concerne un produit générateur d'aérosol de type pulvérisateur doseur pourvu d'un récipient d'aérosol rempli d'une composition d'aérosol qui comprend une solution mère et un agent propulseur et d'une soupape génératrice d'aérosol à pulvérisation dosée qui est fixée au récipient d'aérosol, la quantité pulvérisée à chaque pulvérisation étant de 1 à 3 ml et le niveau de pression acoustique continu équivalent pondéré A pendant 10 secondes de son de pulvérisation dans un dispositif de mesure de niveau acoustique de classe normale étant supérieur ou égal à 62 dB.
PCT/JP2018/045763 2017-12-13 2018-12-12 Produit générateur d'aérosol de type pulvérisateur doseur et procédé d'utilisation de produit générateur d'aérosol de type pulvérisateur doseur WO2019117216A1 (fr)

Priority Applications (1)

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JP2019559182A JP7328897B2 (ja) 2017-12-13 2018-12-12 定量噴射型エアゾール製品および定量噴射型エアゾール製品の使用方法

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JP2017-238441 2017-12-13
JP2017238441 2017-12-13

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WO2019117216A1 true WO2019117216A1 (fr) 2019-06-20

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023106385A1 (fr) * 2021-12-09 2023-06-15 アース製薬株式会社 Produit d'aérosol de type à pulvérisation de quantité fixe

Citations (7)

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JP2001293402A (ja) * 2000-04-13 2001-10-23 Daizo:Kk エアゾール製品
US20090032617A1 (en) * 2005-09-23 2009-02-05 Philip Craig Withers Spray Caps for Generating Spraying Sounds Having Enhanced Perceived Loudness
JP2010100342A (ja) * 2009-12-07 2010-05-06 Daizo:Kk エアゾール製品
WO2011065413A1 (fr) * 2009-11-25 2011-06-03 株式会社ダイゾー Buse de pulvérisation et produit d'aérosol
JP2011219132A (ja) * 2010-04-09 2011-11-04 Daizo:Kk エアゾール製品
JP2012115792A (ja) * 2010-12-02 2012-06-21 Kobayashi Pharmaceutical Co Ltd エアゾール噴射装置
JP2016222267A (ja) * 2015-05-28 2016-12-28 株式会社ダイゾー エアゾール製品

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JP2001302445A (ja) * 2000-04-17 2001-10-31 Daizo:Kk エアゾール製品
JP2007031479A (ja) * 2005-07-22 2007-02-08 Toyo Aerosol Ind Co Ltd 噴霧用エアゾール組成物およびエアゾール製品
US9327898B2 (en) * 2012-06-26 2016-05-03 Conopco, Inc. Aerosol spray production

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001293402A (ja) * 2000-04-13 2001-10-23 Daizo:Kk エアゾール製品
US20090032617A1 (en) * 2005-09-23 2009-02-05 Philip Craig Withers Spray Caps for Generating Spraying Sounds Having Enhanced Perceived Loudness
WO2011065413A1 (fr) * 2009-11-25 2011-06-03 株式会社ダイゾー Buse de pulvérisation et produit d'aérosol
JP2010100342A (ja) * 2009-12-07 2010-05-06 Daizo:Kk エアゾール製品
JP2011219132A (ja) * 2010-04-09 2011-11-04 Daizo:Kk エアゾール製品
JP2012115792A (ja) * 2010-12-02 2012-06-21 Kobayashi Pharmaceutical Co Ltd エアゾール噴射装置
JP2016222267A (ja) * 2015-05-28 2016-12-28 株式会社ダイゾー エアゾール製品

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023106385A1 (fr) * 2021-12-09 2023-06-15 アース製薬株式会社 Produit d'aérosol de type à pulvérisation de quantité fixe

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