WO2019101357A1 - Préparations topiques - Google Patents

Préparations topiques Download PDF

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Publication number
WO2019101357A1
WO2019101357A1 PCT/EP2018/000527 EP2018000527W WO2019101357A1 WO 2019101357 A1 WO2019101357 A1 WO 2019101357A1 EP 2018000527 W EP2018000527 W EP 2018000527W WO 2019101357 A1 WO2019101357 A1 WO 2019101357A1
Authority
WO
WIPO (PCT)
Prior art keywords
particles
acid
agents
topical preparations
skin
Prior art date
Application number
PCT/EP2018/000527
Other languages
German (de)
English (en)
Inventor
Herbert Deutz
Gregor Luthe
Matthias Bischoff
Lena PETER
Original Assignee
Dr. Deutz Kosmetik Gmbh
Smart Material Printing B.V.
Magnetic Hyperthermia Solutions B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Deutz Kosmetik Gmbh, Smart Material Printing B.V., Magnetic Hyperthermia Solutions B.V. filed Critical Dr. Deutz Kosmetik Gmbh
Priority to EP18830134.5A priority Critical patent/EP3713647A1/fr
Publication of WO2019101357A1 publication Critical patent/WO2019101357A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/44—Elemental carbon, e.g. charcoal, carbon black
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Definitions

  • the present invention relates to topical preparations.
  • the present invention relates to a process for the preparation of topical preparations.
  • the present invention relates to the use of the topical preparations.
  • the present invention relates to cosmetics, care products, products for saunas and steam baths, powders, solids, gels, creams, ointments, lotions, drops, sprays, metered aerosols, gargles, lozenges, enemas, enemas, foams, coatings on textile fabrics, face masks, Gauze, patches and medical devices and components of release materials containing or consisting of the topical preparations.
  • Topical medicines or care products are understood in medicine and cosmetics to mean all those medicines or care products that are not taken or injected, but applied locally. Since local application of the drug is brought directly to the site of action, this can often reduce the dose as much as possible and thus reduce the risk of side effects. All superficial organs, ie the skin and mucous membranes of the respiratory tract, the digestive tract and the external eye are accessible to local treatment or care. But also an injection into a joint is a topical (local, intraarticular) treatment.
  • Antibiotics can also be used topically, for example for bacterial skin infections. Sulfonamides are mainly used here.
  • care products means, for example, products for hair care, for skin care, oral care and / or nail care.
  • a very good example are care products for the sauna.
  • a sauna product is used, which is applied to the skin and includes, among other things, black amber.
  • the skin is often rubbed with salt before the sauna session. This is to help the body with the purification.
  • Cleaning preparations for the skin and / or the hair contain surfactants, activated carbon having a particle size of 0.5 to 60 ⁇ m, pearlescing agents and / or at least one structural agent selected from the group of acrylate copolymers and alkoxylated thickeners, and also sodium chloride.
  • an absorbent fire ointment which contains activated carbon powder of a particle size ⁇ 50 pm, an absorbent ointment matrix and an isotonic regulator.
  • the activated carbon is added to an aqueous solution of sodium chloride, after which the water is evaporated.
  • the burn ointment can effectively eliminate the burn wound toxins and prevent the growth of harmful bacteria in the wound. It promotes wound healing and cell proliferation in the wound tissue.
  • the US patent application US 2013/0259913 A1 discloses particles which are not suitable for oral ingestion and contain at least two incompatible hydrophilic and lipophilic substances, the particles being produced by PGSS (Particles from Gas Saturated Solutions). Paraffin and microcrystalline wax may be considered as lipophilic material in addition to numerous other materials. Further information on the waxes are not made.
  • the particles may be used in the manufacture of consumer products such as shampoos, personal cleansers, laundry detergents, dishwashing detergents, non-aqueous liquid products, soap bars, paper products, cosmetics, lotions or skin-care agents. From the US patent application US 2012/0258150 A1 particles are known which are produced by the PGSS process.
  • the particles have a size of 1 nm to 1 mm, preferably 1 nm to 500 pm and contain a water-insoluble polymer and a volatile material, in particular a perfume or a raw material for perfume.
  • a water-insoluble polymer and a volatile material in particular a perfume or a raw material for perfume.
  • a water-insoluble polymer in particular a perfume or a raw material for perfume.
  • paraffin and microcrystalline wax may be considered in addition to numerous other materials. Further information on the waxes are not made.
  • the particles may be used in the manufacture of consumer products such as shampoos, personal cleansers, laundry detergents, dishwashing detergents, non-aqueous liquid products, soap bars, paper products, cosmetics, lotions or skin-care agents.
  • a cosmetic composition which contains a combination of a film-forming polymers with 'a wax microdispersion.
  • the wax particles preferably have average dimensions of less than 1 ⁇ m and preferably less than 0.5 ⁇ m.
  • organic waxes are used.
  • the cosmetic composition may contain alkali salts of organic bases and alkylsulfuric acids and alkylsulfonic acids as surfactants and organic pigments such as carbon black.
  • German Patent DE 699 17 690 T3 discloses the use of a microdispersion of wax in a cosmetic or dermatological composition. Among other things, organic waxes are used. The microdispersion of wax is used as an active ingredient for the prevention and / or treatment of the appearance of wrinkles and / or wrinkles.
  • German Offenlegungsschrift 10 2008 021 007 A1 discloses a microdispersion of waxes which contains inorganic particles of carbon allotropes, in particular carbon nanotubes.
  • the microdispersion is used in cosmetics, especially nail varnishes.
  • German published patent application DE 10 2012 214 662 A1 discloses a cosmetic composition with delayed release of active ingredient.
  • the cosmetic composition contains, based in each case on the particle weight, 30 to 90% by weight of polyalphaolefin waxes and 10 to 70% by weight of one or more cosmetic active ingredients.
  • European patent EP 1 235 546 B1 discloses the use of nanoscale waxes with particle diameters of 10 to 300 nm, which are encased by a protective colloid, for the production of surface-active preparations, such as hair treatment compositions.
  • Protective colloids used are gelatin, casein, gum arabic, lysalbinic acid, starch, polyvinyl alcohols, polyvinylpyrrolidones, polyalkylene glycols and polyacrylates.
  • the cosmetic preparations may also contain sodium chloride.
  • a wax beeswax or sunflower wax is used.
  • crystalline nanocellulose can be used in antiviral ointments.
  • US Patent Application US 2015/0367024 A1 discloses the use of hydrogels of nanofibrillar cellulose for preventing and controlling the disfigurement of scars in wound healing or tissue repair.
  • US Patent Application US 2017/0000903 A1 discloses the use of gels of crystalline cellulose in the field of cosmetics.
  • the gels act as surfactants and can stabilize emulsions.
  • US Patent Application US 2014/0083416 describes processes for producing microcrystalline and nanocrystalline cellulose. It is only cursory that the products can be used in food, cosmetics or medicine.
  • microplastics or microbeads that are not biodegraded, for example as exfoliating particles.
  • Microplasticity is released into the environment, especially in rivers, lakes and seas, where it accumulates in the food chain.
  • the cosmetic industry is now anxious to find substitutes for microplastics.
  • materials such as alumina, silica or ground nutshells are suggested as alternatives.
  • shampoos containing phyllosilicates are already common products.
  • European Patent Application EP 0 563 876 A2 proposes biodegradable microbeads for use in cosmetics and pharmaceuticals. These microbeads can be made by the reaction of glyceraldehyde with natural proteins such as gelatin, albumin and casein.
  • US Patent Application US 2014/0026916 A1 proposes a process for the reduction of environmental pollution in aqueous systems, in which the use of polyhydroxyalkanoate microbeads in personal care products is proposed.
  • the polyhydroxyalkanoate microbeads are said to rapidly sink in aqueous systems.
  • microbeads based on biodegradable, starch-based thermoplastic polymers as described in the European patent EP 2 493 975 B1. These products are commercially available under the trademark Solanyl®.
  • biocides are listed by way of example:
  • biocides are 10,10'-oxybisphenoxoarsine (OBPA), octylisothiazolinone (OIT), dichloroctylisothiazolinone (DCOIT), butylbenzisothiazolinone (BBIT), iodocarb (3-iodo-2-propynylbutylcabamate), zinc pyrithione (zinc salt of pyridine-2-one).
  • thiol-1-oxide trichlosan (polychlorinated phenoxyphenols), silver ions and silver, especially in the form of silver nanoparticles.
  • the known biocides have disadvantages such as a narrow range of applications, a comparatively high toxicity, the tendency to cause resistance and cross-resistance and a still largely unexplained ecological long-term effect.
  • Polyoxometalates are inorganic polyacids with - in contrast to isopolyacids - at least two different central atoms.
  • the second central atom may also be actinide or lanthanide;
  • the tungsten heteropolyacids are thermally much more stable than the analogous molybdenum compounds.
  • E eg, boron, silicon, zinc
  • the heterohexametallate type [(E0 6 ) M 6 O 18 ] ni 2 (Anderson-Evans anions) is frequently found [cf. Römpp Online, Version 3.47 "Heteropolyacids"].
  • US Pat. Nos. 5,824,706 and 6,020,369 disclose the prevention and treatment of respiratory viral infections in which a POM-containing aerosol spray is applied to the lungs.
  • topical POM-containing compositions with the aid of which pollutants, in particular warfare agents, are removed from the environment. Additionally, the topical compositions may still contain cerium, silver, gold, or platinum compounds. In particular, perfluoropolyethers (PFPE) can be used as the carrier.
  • PFPE perfluoropolyethers
  • CEES 2-chloroethylethyl sulfide
  • CEESO 2-chloroethylethyl sulfoxide
  • a bleaching agent which contains peroxide and an activator.
  • the activator may be tungsten silicic acid.
  • the bleach can remove mold and fungus from tiles and curtains.
  • Japanese Unexamined Patent Publication JP 002005281299 A discloses the use of potassium salt of 12-silicotungstic acid as an antibacterial and antifungal agent for use in furniture coating compositions.
  • polymers functionalized with reactive polyoxometalates which serve to decontaminate harmful compounds.
  • German laid-open specification DE 10 2015 000 812 A1 discloses hydrous cleansing and personal care products having a biocidal action which contain polyoxometalates as a biocidal constituent.
  • German Patent Application DE 10 2015 000 813 A1 discloses a method for destroying medicaments and toxins and their metabolites with the aid of polyoxometalate micro and / or nanoparticles.
  • the present invention was based on the object cosmetics, toiletries, products for saunas and steam baths, powders, solids, gels, creams, ointment lotions, drops, sprays, metered aerosols gargles, lozenges, enemas, enemas, suppositories, Foams providing toilet utensils, textile fabrics, face masks, envelopes, sanitary napkins, tampons, gauze, plasters, medical devices, and release materials that function, inter alia, as a moisture regulator and / or water storage, inorganic and / or organic matter based on, in and / or under the human or animal skin, bind, absorb and / or render harmless, suppress the formation of unpleasant odors and / or inhibit unhealthy bacteria and promote healthy bacteria.
  • the aforementioned products are said to be of advantage as medical, especially oncological and dermatological, cosmetics and care products, products for saunas and steam baths and for the care of the skin, mucous membranes, especially mucous membranes in the mouth, on and in the genitals and in the intestine, eyes, ears , Mouth, lips, fingernails, toenails, cornea, warts and scars, in excretions of noxa, drugs, toxins, drugs, acids and bases over the skin, in lesions, itching, burning, intertrigo, infections and redness, for preventive protection, to be used to assist healing processes in existing infections, wounds or burns, in decorative cosmetics, in cosmetic facial care, in hair care and in the personal care of humans and animals.
  • the resulting homogenised mixture is processed into powders, solids, gels, creams, ointments, lotions, drops, sprays, metered aerosols, gargles, lozenge enemas, enemas, suppositories or foams and / or on and / or in textile fabrics, face masks, Gauze, envelopes, bandages, tampons, plasters, medical devices and / or release materials applied, and which is hereinafter referred to as "inventive method".
  • topical preparations as medical and decorative cosmetics, care products and products for saunas and steam baths and for the care of skin, mucous membranes, eyes, ears, mouth, lips, fingernails, toenails, cornea, warts and scars, in excretions of noxious substances, drugs, toxins, medicines, acids and bases via the skin, in the case of lesions, itching, burning, intertrigo, infections and redness, for preventive protection, to support healing processes in existing infections, wounds or burns, in decorative cosmetics, in the cosmetic facial care, in the hair care and in the personal care of humans and animals, which is referred to below as "inventive use”.
  • the medical and decorative cosmetics, toiletries, products for saunas and steam baths, powders, solids, gels, creams, ointment lotions, drops, sprays, metered aerosols gargle solutions, lozenges, enemas, enemas, suppositories, foams toilet utensils, textile Tissues, facemasks, envelopes, sanitary napkins, tampons, gauze, plasters, medical devices and release materials have functioned well as moisture regulators and / or water storages, inorganic and / or organic substances located on, in and / or under human or animal skin , bind, absorb and / or render harmless, suppress the formation of unpleasant odors and / or inhibit unhealthy bacteria and promote healthy bacteria.
  • the products according to the invention could advantageously be used as medical, in particular oncological and dermatological, cosmetics and care products, products for saunas and steam baths and for the care of skin, mucous membranes, in particular mucous membranes in the mouth, on and in the genitals and in the intestine, eyes, ears, Mouth, lips, fingernails, toenails, cornea, warts and scars, in excretions of noxa, drugs, toxins, medicines, acids and bases over the skin, in lesions, itching, burning, intertrigo, infections and redness, for preventive protection, for Assist healing processes in existing infections, wounds or burns, in decorative cosmetics, in cosmetic facial care, in hair care and in the personal care of humans and animals.
  • topical preparations according to the invention and the products according to the invention could be prepared in a simple and very reproducible manner by the method according to the invention.
  • topical preparations according to the invention were tolerable for allergy sufferers and / or for all skin types.
  • they were bacteriostatic and had an antiviral, fungicidal or fungistatic and nematicidal action.
  • the charcoal particles (A) may consist of charcoal and / or their screenings and / or wood ash, activated carbon, hard coal, animal charcoal, animal waste coal, pyrogenic carbon of different pyrolysis degree, functionalized carbon and / or functionalized coal, pretreated coal, washed coal, coal with different degrees of charring, Extracted coal coke, natural coke and incompletely outgassed coke and / or obtained by a pyrolysis process in a mobile or stationary pyrolysis of predominantly lignin-rich, organic materials such as wood, plant stems, leaves, fruit pits, nut shells and / or bones. Bones have the advantage that they are particularly phosphorus-containing.
  • the pyrolysis process is operated under oxygen exclusion at about 1000 ° C.
  • the person skilled in the art understands how to adapt the pyrolysis conditions to the particular circumstances, such as the type of pyrolysis plant, the ambient pressure and / or the amount of the type and nature of the pyrolysis product. These materials are customary and known and are evident, for example, from German Patent Application DE 10 2015 010 041 A1, paragraphs [0055] to [0064].
  • the coal produced by various processes has intramolecular carbon structures, e.g. can be influenced by the pyrolysis conditions. Thereby, the properties of the carbon used for the process according to the invention can be adapted in view of a high nutrient and water storage capacity.
  • the carbon particles (A) can have a wide variety of morphologies and geometric shapes, so that they can be excellently adapted to the other constituents of the topical preparations according to the invention.
  • cavities can be different in size.
  • spherical carbon particles (A) may have pointed outgrowths in the form of cones. Furthermore, their surface may have depressions so that the carbon particles (A) have a strawberry or raspberry morphology.
  • the dumbbell, tori, needles or plates can be bent in at least one direction of the room. They can be freely selectable in any form.
  • the mean particle size dso of the carbon particles (A) varies between the limits given above.
  • the carbon particles (A) may be monodisperse, oligodisperse and / or polydisperse and therefore be excellently adapted to the particular intended use of the topical preparations according to the invention.
  • the mean particle size co can be measured by transmission electron microscopy (TEM), scanning electron microscopy (SEM), scanning transmission electron microscopy (RTEM), atomic force microscopy (AFM) or scanning tunneling microscopy (TRM). It can be set to the desired value using standard and well-known screening methods.
  • the carbon particles (A) have largely free or completely free surfaces.
  • the amounts of carbon particles (A) used in the topical preparations according to the invention can vary very widely and depend mainly on their intended use.
  • the amounts used are from 0.01 to 20 wt .-%, preferably 0.05 to 18 wt .-% and in particular 0.1 to 15 wt .-%, each based on the total amount of a given inventive topical preparations. For special applications, higher dosages can also be used.
  • Particularly advantageous topical preparations according to the invention comprise particles (B) having an average particle size dso equal to 10 nm to ⁇ 1000 pm, preferably 20 nm to 1000 nm, preferably 30 nm to 800 nm and in particular 40 nm to 600 nm. Containing particles (B) and / or consist of at least one, in particular one, type of nanocrystalline and / or microcrystalline natural waxes and / or semi-synthetic waxes based on natural waxes and / or biodegradable microplastics.
  • wax is a phenomenology term for a series of naturally or synthetically or synthetically obtained substances, which generally have the following properties: kneadable at 20 ° C, solid to brittle-hard, coarse to fine crystalline, translucent to opaque, non-glassy, melting above 40 ° C without decomposition, but already slightly above the melting point relatively low viscosity and generally or advantageously not stringy, have a strong temperature-dependent consistency and solubility and are polishable under light pressure. If more than one of the above-mentioned properties is not met, this substance is not wax according to the DGF (German Society for Fat Science) (see DGF unit method Ml 1 (75)).
  • Waxes differ from similar synthetic or natural products such as resins, plastic masses, metal soaps, etc. mainly in that they generally in the molten, low-viscosity state between about 50 ° C and 90 ° C, in exceptional cases up to about 200 ° C. pass over and virtually free of ash-forming Connections are. Waxes form pastes or gels and usually burn with a sooting flame.
  • a wax (B) which contains polar functional groups, in particular groups which contain heteroatoms from the group of oxygen, nitrogen and / or sulfur, preferably oxygen, particularly preferably hydroxyl groups, polyether groups, in particular polyethylene oxide groups, and / or carboxyl groups.
  • suitable natural waxes are vegetable waxes such as candelilla wax, carnauba wax, Japan wax, esparto wax wax, cork wax, guaruma wax, rice germ oil wax, sugarcane wax, ouricury wax, montan wax, absolute flower waxes, cuba palm wax, cotton wax, flax wax, peat wax, rose wax, jasmine wax, peethawax, myrtle wax and waxy wax ,
  • suitable natural waxes are animal waxes such as spermaceti, wool wax, shellac, china wax, beeswax and ragwort wax.
  • suitable natural waxes are mineral waxes such as ceresin and ozokerite.
  • modified natural waxes are hard waxes, montan ester waxes, Sasol waxes, hydrogenated jojoba waxes, wool wax alcohols (Eucerit), and modified beeswaxes (Cerabellina).
  • the wax particles (B) of natural and semi-synthetic waxes using the gas antisolvent recrystallization (GAS), the PCA (Precipitation with a Compressed Fluid Antisolvent) method, the PGSS method (Particles from Gas Saturated Solutions) or the RESS process (Rapid Expansion of Supercritical Solutions) (see, for example, US Patent Applications US 2012/0258150 A1 and US 2013/0259913 A1).
  • GAS gas antisolvent recrystallization
  • PCA Precipitation with a Compressed Fluid Antisolvent
  • PGSS method Particles from Gas Saturated Solutions
  • RESS process Rapid Expansion of Supercritical Solutions
  • the topical preparations according to the invention may contain biodegradable and non-degradable microplastics or microbeads, which, however, is less preferred according to the invention. If non-biodegradable microplastics is used, their amount should be kept as low as possible.
  • Suitable biodegradable microbeads are known for example from US patent application 2014/0026916 A1. They have a mean particle size dso ⁇ 400 pm and consist of polyhydroxyalkanoates. Polyhydroxyalkanoates (PHA) or polyhydroxy-fatty acids (PHF) are naturally occurring water-insoluble and linear polyesters, which are formed by many bacteria as a reserve for carbon and energy. In nature, they are made by fermenting sugar or fats. These biopolymers are biodegradable and are used to make bioplastics. It has the advantage that they sink to the bottom in water and biodegrade.
  • PHA polyhydroxyalkanoates
  • PHF polyhydroxy-fatty acids
  • biodegradable microbeads are known for example from US patent application US 2010/0278882 A1. They consist of cross-linked proteins, such as silk proteins, and have an average particle size d.sub.50 of from 0.1 .mu.m to 100 .mu.m.
  • biodegradable microbeads are furthermore known from European patent application EP 0 563 876 A2. They are made by cross-linking natural proteins such as gelatin, albumin and casein with glyceraldehyde as a cross-linking agent.
  • the average particle size dso of the wax particles (B) and / or of the biodegradable microbeads (B) can vary widely and thus be perfectly adapted to the requirements of the individual case.
  • the average particle size d 50 is preferably between 1 ⁇ m and ⁇ 1000 ⁇ m, preferably 10 ⁇ m to 700 ⁇ m, more preferably 50 ⁇ m to 500 ⁇ m and in particular 100 ⁇ m to 300 ⁇ m.
  • the wax particles (B) and / or the biodegradable microbeads (B) can be protected by protective colloids from aggregation or agglomeration.
  • Protective colloids are usually water-soluble, preferably biodegradable, polymers such as partially saponified polyvinyl acetate, polyvinyl alcohol, polyvinylpyrrolidone, cellulose ethers (Tylose) such as methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, starch, proteins, alginates, pectins and gelatin.
  • polymers such as partially saponified polyvinyl acetate, polyvinyl alcohol, polyvinylpyrrolidone, cellulose ethers (Tylose) such as methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, starch, proteins, alginates, pectins and gelatin.
  • the content of the topical formulations according to the invention on wax particles and / or biodegradable microbeads (B) can vary widely and can thus be adapted excellently to the respective intended use.
  • a given topical preparation according to the invention based on its total amount, contains 0.1% by weight to 50% by weight, 0.5% to 45% by weight and in particular 1% by weight to 40% by weight of wax particles (B).
  • Further advantageous topical preparations according to the invention comprise particles (C) of an average particle size d 50 of from 10 nm to ⁇ 1000 nm, preferably 300 nm to 900 nm, preferably 650 ⁇ 200 nm and in particular 650 ⁇ 100 nm. They contain at least one type and / or consist of at least one type of nanocrystalline, nanofibrillar, microcrystalline and / or microfibrillar polysaccharides.
  • CNF cellulose nanofibers
  • MFC microfibrillar celluloses
  • MCC microcrystalline celluloses
  • NFP nanofibrillary polysaccharides
  • NC nanocrystalline celluloses
  • BNC bacterial nanocelluloses
  • a given topical preparation according to the invention contains, based on its total amount, from 0.01% by weight to 10% by weight, preferably from 0.02% by weight to 9% by weight and in particular from 0.03 to 8% by weight. -%.
  • Still further advantageous topical preparations according to the invention contain (D): heteropolyacids and isopolyacids and their isomers, defect structures and substructures, collectively called polyoxometalates (POM), in the form of their molecules having a largest molecular diameter ⁇ 2 nm, preferably ⁇ 1, 5 nm and in particular ⁇ 1 nm, collectively called POM molecules and in the form of microparticles and nanoparticles having an average particle size of 1 nm to ⁇ 1000 pm, preferably 2 nm to 500 pm, preferably 5 nm to 250 pm, more preferably 5 nm to 150 pm and in particular 5 nm to 100 pm.
  • POM polyoxometalates
  • the data ⁇ 2 nm, ⁇ 1, 5 nm and ⁇ 1 nm do not include a molecular diameter of 0 nm, but that the lower limit of the molecular diameter is equal to the largest diameter of the smallest existing POM molecule.
  • the mean particle size of the POM microparticles to be used according to the invention and POM nanoparticles measured by transmission electron microscopy (TEM), scanning electron microscopy (SEM), scanning transmission electron microscopy (RTEM), atomic force microscopy (AFM) or scanning tunneling microscopy (TRM) can vary very widely and meet the requirements of the invention To be adjusted individually.
  • the POM microparticles and POM nanoparticles can have a wide variety of morphologies and geometric shapes, so that they can also be perfectly adapted to the requirements of the individual case in this respect.
  • they can be compact and have at least one cavity and / or a core-shell structure, wherein the core and the shell can be constructed of different materials. They may also have different geometric shapes such as spheres, ellipsoids, cubes, cuboids, pyramids, cones, cylinders, rhombuses, dodecahedra, truncated dodecahedra, icosahedra, truncated icosahedra, dumbbells, tori, platelets or needles with circular, oval, elliptical, square, triangular , quadrangular, pentagonal, hexagonal, heptagonal, octagonal, or star-shaped (tri-quad, quadrilateral, pentagonal, or polygonal) outline.
  • geometric shapes such as spheres, ellipsoids, cubes, cuboids, pyramids, cones, cylinders, rhombuses, dodecahedra, truncated dodecahedra, ico
  • POM microparticles and / or POM nanoparticles of different morphology and / or geometric form may have pointed outgrowths in the form of cones.
  • two or three cylindrical POM microparticles and / or POM nanoparticles may assemble to form a T-shaped or Y-shaped particle.
  • their surface may have pits so that the POM microparticles and / or POM nanoparticles have a strawberry, raspberry or blackberry morphology.
  • the dumbbells, tori, needles or plates can be bent in at least one direction of the room.
  • the diameter of the POM microparticles and POM nanoparticles can vary widely and therefore be perfectly adapted to the requirements of the individual case.
  • the diameter of the POM microparticles and / or POM nanoparticles to be used according to the invention, which have no spherical shape, is equal to the longest distance traveled by the respective POM microparticles and POM nanoparticles.
  • the diameter of the nanoparticles preferred according to the invention is preferably 1 nm to ⁇ 1000 pm, preferably 2 nm to 500 pm, preferably 5 nm to 250 pm, more preferably 5 nm to 150 pm and in particular 5 nm to 100 pm.
  • the elemental composition and structure of the POM can also vary very widely.
  • n-prime number here is an integer from 3 to 20 denoting the valence of an anion that varies depending on the variables X and M.
  • TM is a divalent or trivalent transition metal ion such as Mn 2+ , Fe 2+ , Fe 3+ , Co 2+ , Co 3+ , Ni 2+ , Cu 2+ and Zn 2+ .
  • the superscript t is an integer and denotes the valence of an anion, which varies depending on the significance of the variable TM.
  • variable A stands for phosphorus, silicon or germanium and the index x stands for 0 or for an integer from 1 to 40.
  • the index y stands for an integer from 1 to 10
  • the index a stands for one integer from 1 to 8
  • the index b is an integer from 15 to 150.
  • the z factor varies depending on the nature and the degree of oxidation of the variable A.
  • the aqua complexes and the active fragments of the POM XIII are also suitable.
  • y is preferably 6-a, where the index a is an integer of 1 to 5 and the index b is 19.
  • variable A is silicon or germanium
  • the index x is 2
  • the index y is 18
  • the index a is 6
  • the index b is 77.
  • the index x is 2 or 4
  • the index y is 12, 15, 17 or 30
  • the index a is 1, 3 or 6
  • the index b is 62 or 123.
  • the isomers of POM come into consideration.
  • the keggin structure has five isomers, the alpha, beta, gamma, delta, and epsilon structure.
  • defect structures or lacunary structures as well as partial structures can be considered.
  • the anions I to XIII are applied in the form of salts with cations which are approved for cleansing and personal care and pharmaceutical use.
  • Suitable cations are H + , Na + , K + and NH 4 + ,
  • Mono-, di-, tri- or tetra- (C 1 -C 20 -alkylammonium) such as pentadecyldimethyl-ferrocenylmethylammonium, undecyldimethylferrocenylmethylammonium,
  • HISH + histidinium
  • ARGFT argininium
  • LYSH + lysinium
  • oligomers and polymers bearing primary, secondary, tertiary and quaternary ammonium groups, primary, secondary and tertiary sulfonium groups and / or primary, secondary and tertiary phosphonium groups.
  • Synthetic oligomers and polymers are common and well known and are used, for example, in electrodeposition paints.
  • natural cationic oligomers and polymers are polyamino-saccharides such as polyglucosamines, especially chitosan.
  • n number in particular integer, from 1 to 50.
  • suitable POM are disclosed in US Pat. No. 7,097,858 B2, column 14, line 56, to column 17, line 19, and from TABLE 8a, col. 22, line 41, to col. 23, line 28, compounds number 1-53, and TABLE 8b, column 23, line 30, to column 25, line 34, compounds number 1 to 150.
  • the molecular POMs to be used according to the invention can be prepared by means of customary and known wet-chemical processes, such as, for example, precipitation processes.
  • the POM microparticles and POM nanoparticles to be used according to the invention can be prepared by customary and known wet-chemical processes. However, it is also possible to dissolve the POM in water and to spray the resulting solution against a warm stream of air. In addition, it is possible to evaporate the solution under vacuum, being irradiated with IR radiation. Furthermore, it is possible to prepare solutions, in particular aqueous, solutions of POM on cold surfaces, such as frozen, smooth metal surfaces, dry ice, cryogenic organic solvents and liquefied gases, such as methane, ethane propane, butane, methylcyclohexane or benzine, liquid nitrogen or liquid helium spray on and evaporate the dry ice or the liquid substances.
  • solutions, in particular aqueous, solutions of POM on cold surfaces such as frozen, smooth metal surfaces, dry ice, cryogenic organic solvents and liquefied gases, such as methane, ethane propane, butane, methylcyclohexane or benzine
  • the molecular POM, POM microparticles and / or POM nanoparticles described above are unchanged, oxygen-substituted, functionalized, aggregated, agglomerated and / or supported. For example, they may be functionalized, agglomerated and supported. But they can also not be functionalized and not aggregated.
  • They may be dissolved, suspended, lipophilized and / or fluidized with organic groups and / or in and / or on compact and / or porous as acid, salt, soft oxometalate (SOMS), coating and / or polyoxometalate nanocomposite and / or molecular disperse Particles, films, fibers and / or sponges, in hydrogels, in micelles, in vesicles, in microcapsules, in gels, in powders, in and on coatings, in and on plastics, in and on tablets, in creams, lotions, ointments and / or foams and / or in mixtures and / or in conjunction with functional materials, antibiotics and / or biocidal materials.
  • SOMS soft oxometalate
  • the unaltered POMs are the POMs that arise during their manufacture without further functionalization or modification.
  • terminal oxide centers are replaced by other ligands, such as sulfide ions, bromide ions, amino groups, nitrosyl groups, and / or alkoxy groups.
  • ligands such as sulfide ions, bromide ions, amino groups, nitrosyl groups, and / or alkoxy groups.
  • the sulfur-containing POM are also called polyoxothiometalates.
  • the aggregates are loose aggregates of particles that are held together by cohesion and can not be distributed by conventional and known dispersion methods. Their inner surface is smaller than the sum of the surfaces of the primary particles.
  • the agglomerates are aggregates of primary particles and their aggregates, which are bridged over edges and corners. Their inner surface corresponds approximately to the sum of the surfaces of the primary particles.
  • the molecular POM, POM microparticles and POM nanoparticles to be used according to the invention can be present "naked". That is, their surface is not surrounded by a shell and / or is not functionalized.
  • the molecular POM, POM microparticles and POM nanoparticles to be used according to the invention can be surrounded by a shell and / or carry at least one functional group.
  • the material of the shells may be the functional groups or the functional groups may be present directly on the surface of the molecular POM, the POM microparticles, and the POM nanoparticles.
  • the material of the shell and / or the functional groups can be selected so that the molecular POM, POM microparticles and POM nanoparticles to be used according to the invention are particularly rapidly and homogeneously in an organic and / or inorganic, solid or liquid matrix, in particular a distribute and / or modify the physical and / or chemical properties of the molecular POM, POM microparticles, and POM nanoparticles in a particular desired manner, and / or modify the physical and / or chemical properties of the organic and / or inorganic polymeric matrix or inorganic ceramic matrix acting as a support material and / or binder mask.
  • the shells and / or the functional groups may be attached to the surface of the molecular POM, POM microparticles and POM nanoparticles via covalent and / or ionic bonds and / or electrostatic and / or van der Waals forces.
  • the bond between the surface of the molecular POM, POM microparticles and POM nanoparticles and the shell and / or the functional groups can be permanently or reversibly, i. be solvable again.
  • the shells may be constructed of organic, inorganic and organometallic, polymeric, oligomeric and low molecular weight materials or combinations of at least two of these materials.
  • the topical preparations according to the invention may contain at least one ingredient (E) commonly used for topical preparations, selected from the group consisting of water, phyllosilicates, ground clays, bolus americus clays, healing earth, nut shells, willow bark, lapacho healing cortices, siliceous earth, pumice stones, Geopolymers, amines, gemstones, trace elements and neutral inorganic salts, beta-glucans, glutathione, albumin, xylan, phytates, complexing agents, antioxidants, radical scavengers, menthol, caffeine, teein, papain, esculin hemihydrate, carotenoids, lecithins, abscinic acid, cyanidin, guanidine, Urea, thiourea, fillers, solvents, humectants, solubilizers, nonionic wetting agents, buffers, thickeners, binders, coating agents, disintegrants
  • Cell differentiation reagents analgesics, anesthetics, anesthetics, contrast agents, enzymes, cytokines, antihistamines, immunomodulators, hemostatic reagents, hormones, angiogenic and antiangiogenic agents, neurotransmitters, therapeutic oligonucleotides, viral particles, growth factors, retinoids, cell adhesion factors, extracellular matrix glycoproteins, osteogenic factors, antibodies, antigens , Steroids, analgesics, potassium sulfate, royal jelly, propolis, encapsulated perfumes, nutrients hexahydroxycyclohexanehexaphosphoric acid ester salt nanoparticles, especially salts of phytic acid, and surfactants, in effective amounts.
  • suitable ingredients are in particular phyllosilicates, which are particularly preferred as nanoparticles and / or microparticles having an average particle size dso of 1 nm to ⁇ 1000 pm, preferably 10 nm to 900 pm, preferably 300 nm to 1000 nm, particularly preferably 650 ⁇ 200 nm preferably 650 ⁇ 150 nm and in particular 650 ⁇ 100 nm
  • the elemental composition and the structure of the layered silicate micro- and / or nanoparticles can also vary widely.
  • classification of the silicates into the following structures is known:
  • Phyllosilicates are silicates whose silicates consist of layers of corner-sharing S1O 4 tetrahedra. These layers and / or bilayers are not further linked to one another.
  • the technically important and in sedimentary rocks widespread clay minerals are also phyllosilicates.
  • the layered structure of these minerals determines the shape and properties of the crystals. They are usually tabular to leafy with good to perfect cleavage parallel to the layers.
  • the number of rings that make up the silicate layers often determines the symmetry and shape of the crystals. Between the layers, water molecules, large cations and / or lipids can be stored.
  • bentonite from the group of montmorillonites ((Na, Ca) o .3 (Al, Mg) 2 Si 4 0io (OH) 2 -nH 2 0).
  • Bentonite is a mixture of various clay minerals and contains montmorillonite as its main constituent.
  • sodium bentonite absorbs water, it can absorb a variety of its own dry weight.
  • calcium bentonite can absorb fats and / or oils.
  • the layered silicate micro- and / or nanoparticles described above are functionalized, non-functionalized, aggregated, non-aggregated, agglomerated, non-agglomerated, supported and / or unsupported.
  • they may be functionalized, agglomerated and supported. But they can also not be functionalized and aggregated.
  • Polyethylene glycols (macrogols, PEG); Polyethylene oxides (PEO) (tablets, ointments, creams);
  • Emulsifiers cetylstearyl alcohol, glycerol monostearate, lecithin, fatty acid esters of sorbitan, polyoxyethylene sorbitan (polysorbates), polyoxyethylene, polyoxyethylene fatty alcohol ethers (emulsions, creams), methyl glucose, sesquistearates, stearic acid and derivatives thereof, acrylate-based emulsifiers, e.g. Acrylates / C 10-330 Alkyl Acrylate Crosspolymer
  • Solubilizers and / or wetting agents polyethylene glycols (PEG, macrogols), polyethylene oxides (PEO, PolyOx), polysorbates (solutions, suspensions) • buffer: dipotassium hydrogen phosphate sodium dihydrogen phosphate,
  • Thickeners and binders starches, guar gum, xanthan gum, alginate, carrageenan, pectin, tragacanth, polyacrylic acids, polyvinylpyrrolidone (granules, tablets); fumed silica, substituted cellulose ethers (methylcellulose, ethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose) (tablets, gels, viscous solutions), Butyrospermum Parkii Butter, MAGNESIUM SULFATE
  • sucrose sucrose (sugar dragee); Gelatin (capsules);
  • Gelatin polysuccinate (“soft capsules”), polyacrylates, ethylcellulose, methylcellulose (filmcoating: film capsules, film-coated tablets, pellets)
  • disintegrants and / or disintegrants starches (tablets, tabs);
  • Croscarmellosis tablettes, capsules, granules
  • Sodium bicarbonate in combination with citric acid effervescent tablets
  • Lubricants and / or mold release agents polyethylene glycols (PEG, macrogols), polyethylene oxides (PEO), talc, magnesium stearate (tableting)
  • Flow control agent fumed silica (powders, granules)
  • Antioxidants butylated hydroxytoluene, all-rac-a-tocopherol
  • Sweeteners, flavoring agents sucrose, sorbitol, sweeteners such as saccharin sodium and cyclamate
  • Ammonium bicarbonate ammonium bicarbonate • AMMONIUM CARBONATE
  • Citric acid citric acid
  • Vitamin C Ascorbic acid
  • vitamin E alpha tocopheryl acetate
  • Anthocyanins (cyanidin, peonidin, malvidin, delphinidin, petunidin, pelargonidin)
  • Curcumin curcumin; 1, 7-bis (4-hydroxy-3-methoxyphenyl) hepta-1, 6-diene-3,5-dione carmine; carminic
  • chlorophyll Chlorophyll a / b; Trisodium (2S-trans) - [18-carboxy-20- (carboxymethyl) -13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-8-vinyl-21H, 23H-porphine 2-propionato (5)
  • cyclomethicone Composed of octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5) and dodecamethylcyclohexasiloxane (D6)
  • Lactic acid 2-hydroxypropionic acid, 2-hydroxypropanoic acid y-6
  • Ammonium benzoate, ammonium salt of benzoic acid AMMONIUM BISULFITE
  • Butyl paraben (potassium salt); 4-hydroxybenzoic acid butyl ester (potassium salt)
  • Ethyl paraben (potassium salt); 4-hydroxybenzoic acid ethyl ester (potassium salt)
  • Methylparaben (potassium salt); 4-hydroxybenzoic acid methyl ester (potassium salt)
  • Butyl paraben (sodium salt); 4-Hydroxybenzoic acid butyl ester (sodium salt) SODIUM ETHYLPARABEN
  • Methylparaben sodium salt
  • 4-Hydroxybenzoic acid methyl ester sodium salt
  • Triclocarban 1- (4-chlorophenyl) -3- (3,4-dichlorophenyl) urea
  • alkyl acrylates C10-C30
  • acrylic acid methacrylic acid and / or other alkyl acrylates
  • Cetearyl alcohol mixture of 1-hexadecanol (cetyl alcohol) and 1-octadecanol (stearyl alcohol)
  • Potassium alginate potassium salt of alginic acid
  • Palmitic acid glycol esters 2-Hydroxyethylpalmitat
  • Propylene glycol stearate Ester of stearic acid and propylene glycol (1: 1) containing sodium or potassium stearate *
  • Cetearyl isononanoate esters of isononanoic acid and cetearyl alcohol
  • Vitamins include Vitamin A, Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B4, Vitamin B5, Vitamin B6, Vitamin B7, Vitamin B8, Vitamin B9, Vitamin B12, Vitamin C, Vitamin D, Vitamin E, Vitamin K
  • Substances that are usually added to surfactant preparations in order to counteract their degreasing character are substances which are also called moisturizers and / or moisturizers.
  • moisturizing substances are used.
  • the list below is exemplary and not exhaustive. The person skilled in the art, on the basis of his general knowledge, can easily name further possible refatting substances.
  • Glyceryl trimyristate Esterification product of glycerine and myristic acid (1: 3)
  • Glyceryl tripalmitate Esterification product of glycerol and palmitic acid (1: 3)
  • Oils are a collective term for different liquid fatty substances. These include, inter alia, mineral oils, silicone oils and / or oils of natural origin, such as vegetable oils and / or essential oils. These are often characterized by monounsaturated and / or polyunsaturated fatty acids. Oils of animal origin are usually referred to as fats. In addition, many oil components used in cosmetics are based on natural starting materials synthetically produced. Just like the lubricating substances, oil components prevent the premature drying of the skin and / or hair. In the list below, the oils are listed by example and not by definition. The person skilled in the art, on the basis of his general knowledge, can easily name further possible oils.
  • Cetearyl alcohol mixture of 1-hexadecanol (cetyl alcohol) and 1-octadecanol (stearyl alcohol)
  • cyclomethicone Composed of octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5) and dodecamethylcyclohexasiloxane (D6)
  • Glycerol stearate glycerol monostearate, stearic acid-glycerol ester
  • Macadamia ; Macadamia nut, genuine; macadamia nut oil
  • Macadamia trifoliate; macadamia nut oil
  • avocado oil avocado oil
  • Essential oils are volatile, intense-smelling mixtures of oily consistency that are sparingly soluble in water. They are usually obtained from vegetable raw materials by steam distillation. They can also be obtained by synthesis, extraction or by squeezing. Herbal substances such as menthol, cineole, vanillin and / or thymol are also referred to as essential oils. In medicine, they are used depending on the oil for the treatment of numerous complaints, u. a. Muscle and joint pain, infectious diseases, colds and discomfort in the gastrointestinal tract. Furthermore, they are used in cosmetics especially for perfuming.
  • Flavors are products that are added to foods, for example, to give them a special smell and / or taste.
  • An aroma can consist of numerous flavors, aroma extracts, thermally derived reaction aromas, smoke flavors and / or aroma precursors. Most flavors are used industrially in food production, and some flavors are also available in retail stores. Flavorings are chemically defined substances with taste-giving properties (aroma properties), which are used for the production of flavors. There are different natural, nature-identical and / or artificial flavorings.
  • fragrances used in cosmetics are organic compounds from the animal and plant kingdoms. Furthermore, fragrances are compounds that are synthetic can be produced. The purpose of the fragrances in cosmetic products is to mask the odor of a drug and continue to trigger pleasant sensations in the consumer. Perfumes in the narrower sense are fragrances and fragrance mixtures that are supposed to change or mask the body odor.
  • anisalcohol Anisyl alcohol, 4-methoxybenzyl alcohol
  • Lactic acid 2-hydroxypropionic acid, 2-hydroxypropanoic acid
  • Vitamin C Ascorbic acid
  • avocado oil avocado oil
  • Zinc lactate (zinc salt of lactic acid)
  • Steareth-20-methacrylate is an ester of methacrylic acid with polyethylene glycol (avg. 20 units -CH 2 -CH 2 -O-)
  • T ololsulphonamide-formaldehyde resin • PHTHALIC ANHYDRIDE / TRIMELLITIC ANHYDRIDE / GLYCOLS COPOLYMER
  • Tanning agents, tanning agents and / or tannin extracts are tanning agents and / or tannin extracts:
  • tannins are chemicals used to tan animal skins. By treating with tannins the animal skins are converted into leather, which among other things prevents the rot. Furthermore, there are naturally occurring, ie natural, as well as artificially produced, ie synthetic tannins.
  • Tanning agents are plant parts and / or mixtures containing one and / or more tannins. The terms tanning agent and / or tanning agent are often used as synonyms.
  • a tannin extract is an extract of a Tanning agent. After extraction, the tanning agent is in a higher concentration, without any interfering constituents of the starting material. Vegetable tannins, also called tannins, are also used in medicine. Furthermore, tannins are known as taste components of wine and tea.
  • Synthetic tanning agents Synthetic tanning agents (Syntans) based on phenol derivatives
  • Bittern refers to all chemical compounds that have a bitter taste. They are not a chemically unified group, but are characterized only by the fact that they taste bitter. The following bitter substances are only exemplary and not fully listed. The person skilled in the art, on the basis of his general knowledge, can easily name other possible bitter substances.
  • Dyes, colored pigments, white pigments, fluorescent pigments and phosphorescent pigments (phosphorus) can be added in many different ways to the topical preparations according to the invention. Preference is given to chalk, talc, montmorillonite, Clay minerals, papers, paper-like materials and / or titanium dioxide, also black titanium dioxide.
  • Plant extracts are extracts of plants used in cosmetics.
  • the following list of plant extracts is exemplary and not exhaustive. The person skilled in the art can easily name further possible plant extracts.

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Abstract

L'invention concerne des préparations topiques, contenant (A) au moins un type de particules carbonées présentant une taille moyenne de particule d50 = 650 ± 200 nm, des procédés pour leur préparation, leur utilisation, en particulier comme cosmétiques, produits de soins et produits pour saunas et bains de vapeur et pour les soins de la peau, des muqueuses, des yeux, des oreilles, de la bouche, des lèvres, des ongles, des ongles des pieds, de la cornée, des verrues et des cicatrices, lors d'excrétions d'agents nocifs, de drogues, de toxines, de médicaments, d'acides et de bases via la peau, dans le cas de lésions, de prurit, de brûlures, d'infections et de rougeurs, pour la protection préventive, pour le soutien de processus de guérison dans le cas d'infections, de plaies ou de brûlures existantes, dans la thérapie contre le cancer, la chimiothérapie, les maladies de la peau telle que : le psoriasis, la dermite atopique, l'acné, l'eczéma, l'eczéma atrophique, les verrues, la rosacée, l'herpès, le zona, la rougeole, les oreillons, la rubéole, la varicelle, le syndrome pieds-mains-bouche, dans la cosmétique décorative, dans les soins cosmétiques du visage, dans les soins capillaires et les soins corporels de l'homme et de l'animal, ainsi que des produits les contenant.
PCT/EP2018/000527 2017-11-25 2018-11-22 Préparations topiques WO2019101357A1 (fr)

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Cited By (4)

* Cited by examiner, † Cited by third party
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DE102021004907A1 (de) 2021-09-29 2023-03-30 Smart Material Printing B.V. Mechanochemisch vorbehandelte, schwermetallfreie Aktivkohlepartikel A zur Verwendung in der Medizin
DE102021004906A1 (de) 2021-09-29 2023-03-30 Smart Material Printing B.V. Schwermetallfreie topische Medizinprodukte und Kosmetika, Verfahren zu ihrer Herstellung und ihre Verwendung
DE102021004905A1 (de) 2021-09-29 2023-03-30 Smart Material Printing B.V. Mechanochemisch vorbehandelte, schwermetallfreie Aktivkohlepartikel A
WO2023052393A1 (fr) 2021-09-29 2023-04-06 Smart Material Printing B.V. Particules de charbon actif a prétraitées mécanochimiquement exemptes de métaux lourds, médicaments topiques, produits médicinaux et produits cosmétiques, procédé de production et utilisations

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DE102021004907A1 (de) 2021-09-29 2023-03-30 Smart Material Printing B.V. Mechanochemisch vorbehandelte, schwermetallfreie Aktivkohlepartikel A zur Verwendung in der Medizin
DE102021004906A1 (de) 2021-09-29 2023-03-30 Smart Material Printing B.V. Schwermetallfreie topische Medizinprodukte und Kosmetika, Verfahren zu ihrer Herstellung und ihre Verwendung
DE102021004905A1 (de) 2021-09-29 2023-03-30 Smart Material Printing B.V. Mechanochemisch vorbehandelte, schwermetallfreie Aktivkohlepartikel A
WO2023052393A1 (fr) 2021-09-29 2023-04-06 Smart Material Printing B.V. Particules de charbon actif a prétraitées mécanochimiquement exemptes de métaux lourds, médicaments topiques, produits médicinaux et produits cosmétiques, procédé de production et utilisations

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