WO2019100911A1 - 化合物及使用了该化合物的有机电致发光器件 - Google Patents
化合物及使用了该化合物的有机电致发光器件 Download PDFInfo
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- WO2019100911A1 WO2019100911A1 PCT/CN2018/112442 CN2018112442W WO2019100911A1 WO 2019100911 A1 WO2019100911 A1 WO 2019100911A1 CN 2018112442 W CN2018112442 W CN 2018112442W WO 2019100911 A1 WO2019100911 A1 WO 2019100911A1
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 925
- 125000003118 aryl group Chemical group 0.000 claims abstract description 49
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 47
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 32
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 28
- 150000002367 halogens Chemical class 0.000 claims abstract description 28
- 239000001257 hydrogen Substances 0.000 claims abstract description 26
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims abstract description 15
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims abstract description 14
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 11
- KKCJKJCQZURMPE-UHFFFAOYSA-N [hydroxy(nitro)silyl]formonitrile Chemical compound C(#N)[SiH](O)[N+](=O)[O-] KKCJKJCQZURMPE-UHFFFAOYSA-N 0.000 claims abstract description 10
- 125000005549 heteroarylene group Chemical group 0.000 claims abstract description 10
- 125000000732 arylene group Chemical group 0.000 claims abstract description 9
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims abstract description 7
- 229910052805 deuterium Inorganic materials 0.000 claims abstract description 6
- 125000000714 pyrimidinyl group Chemical group 0.000 claims abstract description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 61
- -1 methoxy, cyano, phenyl Chemical group 0.000 claims description 60
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 54
- 125000001624 naphthyl group Chemical group 0.000 claims description 37
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 31
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 24
- 125000005561 phenanthryl group Chemical group 0.000 claims description 23
- 125000001424 substituent group Chemical group 0.000 claims description 23
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 20
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 claims description 18
- 239000012044 organic layer Substances 0.000 claims description 18
- 125000004076 pyridyl group Chemical group 0.000 claims description 18
- 235000010290 biphenyl Nutrition 0.000 claims description 16
- 239000004305 biphenyl Substances 0.000 claims description 15
- YJTKZCDBKVTVBY-UHFFFAOYSA-N 1,3-Diphenylbenzene Chemical group C1=CC=CC=C1C1=CC=CC(C=2C=CC=CC=2)=C1 YJTKZCDBKVTVBY-UHFFFAOYSA-N 0.000 claims description 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 125000002541 furyl group Chemical group 0.000 claims description 12
- 125000001544 thienyl group Chemical group 0.000 claims description 11
- 125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 10
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 claims description 10
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 229910052717 sulfur Inorganic materials 0.000 claims description 9
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 8
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 125000005259 triarylamine group Chemical group 0.000 claims description 8
- SLGBZMMZGDRARJ-UHFFFAOYSA-N Triphenylene Natural products C1=CC=C2C3=CC=CC=C3C3=CC=CC=C3C2=C1 SLGBZMMZGDRARJ-UHFFFAOYSA-N 0.000 claims description 7
- 125000006267 biphenyl group Chemical group 0.000 claims description 7
- 125000005580 triphenylene group Chemical group 0.000 claims description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 6
- 125000003914 fluoranthenyl group Chemical group C1(=CC=C2C=CC=C3C4=CC=CC=C4C1=C23)* 0.000 claims description 6
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 5
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 5
- 125000005509 dibenzothiophenyl group Chemical group 0.000 claims description 5
- 229910052731 fluorine Inorganic materials 0.000 claims description 5
- 239000011737 fluorine Substances 0.000 claims description 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 4
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000005577 anthracene group Chemical group 0.000 claims description 4
- 125000005241 heteroarylamino group Chemical group 0.000 claims description 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 3
- 125000001769 aryl amino group Chemical group 0.000 claims description 3
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 claims description 2
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 287
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 513
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 387
- 238000006243 chemical reaction Methods 0.000 description 324
- 238000003756 stirring Methods 0.000 description 323
- 238000002360 preparation method Methods 0.000 description 321
- 239000007787 solid Substances 0.000 description 298
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 214
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 181
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 181
- 239000000203 mixture Substances 0.000 description 171
- 239000010410 layer Substances 0.000 description 137
- 235000019441 ethanol Nutrition 0.000 description 132
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 128
- 229910000027 potassium carbonate Inorganic materials 0.000 description 107
- 229910052757 nitrogen Inorganic materials 0.000 description 103
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 100
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 99
- 238000010992 reflux Methods 0.000 description 94
- 239000012299 nitrogen atmosphere Substances 0.000 description 83
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 72
- 238000004440 column chromatography Methods 0.000 description 69
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 66
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 65
- 238000000746 purification Methods 0.000 description 49
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 44
- SAHIZENKTPRYSN-UHFFFAOYSA-N [2-[3-(phenoxymethyl)phenoxy]-6-(trifluoromethyl)pyridin-4-yl]methanamine Chemical compound O(C1=CC=CC=C1)CC=1C=C(OC2=NC(=CC(=C2)CN)C(F)(F)F)C=CC=1 SAHIZENKTPRYSN-UHFFFAOYSA-N 0.000 description 40
- 239000008346 aqueous phase Substances 0.000 description 40
- HMUNWXXNJPVALC-UHFFFAOYSA-N 1-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C(CN1CC2=C(CC1)NN=N2)=O HMUNWXXNJPVALC-UHFFFAOYSA-N 0.000 description 37
- 238000002347 injection Methods 0.000 description 32
- 239000007924 injection Substances 0.000 description 32
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 30
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 30
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 30
- BMQDAIUNAGXSKR-UHFFFAOYSA-N (3-hydroxy-2,3-dimethylbutan-2-yl)oxyboronic acid Chemical compound CC(C)(O)C(C)(C)OB(O)O BMQDAIUNAGXSKR-UHFFFAOYSA-N 0.000 description 26
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 26
- 230000000052 comparative effect Effects 0.000 description 25
- 239000003480 eluent Substances 0.000 description 24
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 22
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 22
- ABRVLXLNVJHDRQ-UHFFFAOYSA-N [2-pyridin-3-yl-6-(trifluoromethyl)pyridin-4-yl]methanamine Chemical compound FC(C1=CC(=CC(=N1)C=1C=NC=CC=1)CN)(F)F ABRVLXLNVJHDRQ-UHFFFAOYSA-N 0.000 description 22
- 238000000034 method Methods 0.000 description 22
- 229910000160 potassium phosphate Inorganic materials 0.000 description 22
- 235000011009 potassium phosphates Nutrition 0.000 description 22
- 229910052708 sodium Inorganic materials 0.000 description 22
- 239000011734 sodium Substances 0.000 description 22
- 230000005525 hole transport Effects 0.000 description 21
- 239000003208 petroleum Substances 0.000 description 21
- 239000000243 solution Substances 0.000 description 21
- 239000002904 solvent Substances 0.000 description 21
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 20
- DORMTBIPKNPJPY-UHFFFAOYSA-N acetic acid;iodobenzene Chemical compound CC(O)=O.IC1=CC=CC=C1 DORMTBIPKNPJPY-UHFFFAOYSA-N 0.000 description 20
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 20
- BWHDROKFUHTORW-UHFFFAOYSA-N tritert-butylphosphane Chemical compound CC(C)(C)P(C(C)(C)C)C(C)(C)C BWHDROKFUHTORW-UHFFFAOYSA-N 0.000 description 20
- 239000008096 xylene Substances 0.000 description 20
- VNFWTIYUKDMAOP-UHFFFAOYSA-N sphos Chemical compound COC1=CC=CC(OC)=C1C1=CC=CC=C1P(C1CCCCC1)C1CCCCC1 VNFWTIYUKDMAOP-UHFFFAOYSA-N 0.000 description 19
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 17
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 16
- NSGDYZCDUPSTQT-UHFFFAOYSA-N N-[5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide Chemical compound Cc1c(Br)cn(Cc2ccc(F)cc2)c(=O)c1NC(=O)C1CCCCCC1 NSGDYZCDUPSTQT-UHFFFAOYSA-N 0.000 description 16
- QYGCZEVLULCLAH-UHFFFAOYSA-N OBO.ClC1=CC=CC=C1 Chemical compound OBO.ClC1=CC=CC=C1 QYGCZEVLULCLAH-UHFFFAOYSA-N 0.000 description 16
- 239000007864 aqueous solution Substances 0.000 description 16
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 16
- 239000007791 liquid phase Substances 0.000 description 16
- 239000012074 organic phase Substances 0.000 description 16
- 230000008569 process Effects 0.000 description 16
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 15
- 238000007740 vapor deposition Methods 0.000 description 15
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 14
- 239000000543 intermediate Substances 0.000 description 14
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- ZEEBGORNQSEQBE-UHFFFAOYSA-N [2-(3-phenylphenoxy)-6-(trifluoromethyl)pyridin-4-yl]methanamine Chemical compound C1(=CC(=CC=C1)OC1=NC(=CC(=C1)CN)C(F)(F)F)C1=CC=CC=C1 ZEEBGORNQSEQBE-UHFFFAOYSA-N 0.000 description 12
- 229910001873 dinitrogen Inorganic materials 0.000 description 12
- 230000009477 glass transition Effects 0.000 description 12
- 239000002346 layers by function Substances 0.000 description 12
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 12
- 238000000967 suction filtration Methods 0.000 description 12
- 239000010408 film Substances 0.000 description 11
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- LIGACIXOYTUXAW-UHFFFAOYSA-N phenacyl bromide Chemical compound BrCC(=O)C1=CC=CC=C1 LIGACIXOYTUXAW-UHFFFAOYSA-N 0.000 description 11
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 10
- VQFAIAKCILWQPZ-UHFFFAOYSA-N bromoacetone Chemical compound CC(=O)CBr VQFAIAKCILWQPZ-UHFFFAOYSA-N 0.000 description 10
- 235000019439 ethyl acetate Nutrition 0.000 description 10
- 125000000623 heterocyclic group Chemical group 0.000 description 10
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 9
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 9
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 8
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- PYOKUURKVVELLB-UHFFFAOYSA-N trimethyl orthoformate Chemical compound COC(OC)OC PYOKUURKVVELLB-UHFFFAOYSA-N 0.000 description 8
- CAYQIZIAYYNFCS-UHFFFAOYSA-N (4-chlorophenyl)boronic acid Chemical compound OB(O)C1=CC=C(Cl)C=C1 CAYQIZIAYYNFCS-UHFFFAOYSA-N 0.000 description 7
- 239000002019 doping agent Substances 0.000 description 7
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- 230000008020 evaporation Effects 0.000 description 7
- 238000004768 lowest unoccupied molecular orbital Methods 0.000 description 7
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 7
- 235000019341 magnesium sulphate Nutrition 0.000 description 7
- 235000011056 potassium acetate Nutrition 0.000 description 7
- 230000000171 quenching effect Effects 0.000 description 7
- NOUCKIVQOMKHET-UHFFFAOYSA-N quinazoline;2h-triazole Chemical group C=1C=NNN=1.N1=CN=CC2=CC=CC=C21 NOUCKIVQOMKHET-UHFFFAOYSA-N 0.000 description 7
- 230000006798 recombination Effects 0.000 description 7
- 238000005215 recombination Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 239000000758 substrate Substances 0.000 description 7
- KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 6
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 description 6
- BTTNYQZNBZNDOR-UHFFFAOYSA-N 2,4-dichloropyrimidine Chemical compound ClC1=CC=NC(Cl)=N1 BTTNYQZNBZNDOR-UHFFFAOYSA-N 0.000 description 6
- LDXJRKWFNNFDSA-UHFFFAOYSA-N 2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound C1CN(CC2=NNN=C21)CC(=O)N3CCN(CC3)C4=CN=C(N=C4)NCC5=CC(=CC=C5)OC(F)(F)F LDXJRKWFNNFDSA-UHFFFAOYSA-N 0.000 description 6
- 239000000460 chlorine Substances 0.000 description 6
- 238000000151 deposition Methods 0.000 description 6
- 125000006575 electron-withdrawing group Chemical group 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 238000010791 quenching Methods 0.000 description 6
- OHVLMTFVQDZYHP-UHFFFAOYSA-N 1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-2-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound N1N=NC=2CN(CCC=21)C(CN1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)=O OHVLMTFVQDZYHP-UHFFFAOYSA-N 0.000 description 5
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 5
- MFGSTSNUMVXOHJ-UHFFFAOYSA-M [I+].CC([O-])=O Chemical compound [I+].CC([O-])=O MFGSTSNUMVXOHJ-UHFFFAOYSA-M 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 238000006467 substitution reaction Methods 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
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- FDPIMTJIUBPUKL-UHFFFAOYSA-N dimethylacetone Natural products CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 125000005945 imidazopyridyl group Chemical group 0.000 description 1
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 1
- 125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 125000001715 oxadiazolyl group Chemical group 0.000 description 1
- AFSVSXMRDKPOEW-UHFFFAOYSA-N oxidoiodine(.) Chemical group I[O] AFSVSXMRDKPOEW-UHFFFAOYSA-N 0.000 description 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000001791 phenazinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3N=C12)* 0.000 description 1
- 229950000688 phenothiazine Drugs 0.000 description 1
- 125000001644 phenoxazinyl group Chemical group C1(=CC=CC=2OC3=CC=CC=C3NC12)* 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- QLULGIRFKAWHOJ-UHFFFAOYSA-N pyridin-4-ylboronic acid Chemical compound OB(O)C1=CC=NC=C1 QLULGIRFKAWHOJ-UHFFFAOYSA-N 0.000 description 1
- QJZUKDFHGGYHMC-UHFFFAOYSA-N pyridine-3-carbaldehyde Chemical compound O=CC1=CC=CN=C1 QJZUKDFHGGYHMC-UHFFFAOYSA-N 0.000 description 1
- 125000005551 pyridylene group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- YVTHLONGBIQYBO-UHFFFAOYSA-N zinc indium(3+) oxygen(2-) Chemical compound [O--].[Zn++].[In+3] YVTHLONGBIQYBO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K50/00—Organic light-emitting devices
- H10K50/10—OLEDs or polymer light-emitting diodes [PLED]
- H10K50/14—Carrier transporting layers
- H10K50/16—Electron transporting layers
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
- H10K85/60—Organic compounds having low molecular weight
- H10K85/649—Aromatic compounds comprising a hetero atom
- H10K85/657—Polycyclic condensed heteroaromatic hydrocarbons
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
- H10K85/60—Organic compounds having low molecular weight
- H10K85/649—Aromatic compounds comprising a hetero atom
- H10K85/657—Polycyclic condensed heteroaromatic hydrocarbons
- H10K85/6572—Polycyclic condensed heteroaromatic hydrocarbons comprising only nitrogen in the heteroaromatic polycondensed ring system, e.g. phenanthroline or carbazole
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K50/00—Organic light-emitting devices
- H10K50/10—OLEDs or polymer light-emitting diodes [PLED]
- H10K50/14—Carrier transporting layers
- H10K50/16—Electron transporting layers
- H10K50/166—Electron transporting layers comprising a multilayered structure
Definitions
- the present invention relates to a class of organic compounds and organic electroluminescent devices using the same.
- the phosphorescent dye is generally not used alone as a light-emitting layer, but is doped in a suitable host material to form a host-guest light-emitting system to attenuate the high-concentration quenching effect of the triplet excitons.
- a suitable host material to form a host-guest light-emitting system to attenuate the high-concentration quenching effect of the triplet excitons.
- the energy gap of the host material is greater than the dye, and the triplet energy level ET is higher than the triplet energy level ET of the dye molecule. In this way, the T1 state energy can be smoothly transferred from the host material to the phosphorescent dye or the triplet excitons can be confined to the dye molecules, thereby achieving high-efficiency phosphorescence emission.
- the glass transition temperature Tg of the host material is related to the film formability and thermal stability of the material. Materials with low Tg temperatures have poor thermal stability and are easy to crystallize or agglomerate, which will greatly reduce the life of the device and seriously reduce device efficiency.
- CBP is a widely used phosphorescent host material, and it has been reported to use it as a host, BCP, BAlq, etc. as a hole blocking material to obtain a highly efficient OLED device.
- Japanese pioneer companies have also reported the use of BAlq derivatives as host materials to obtain high-efficiency OLED devices.
- Patent Document 1 discloses a compound using a fused bicyclic group as a skeleton structure
- Patent Document 2 and Patent Document 3 disclose a compound in which a nitrogen-containing heteroaryl group such as a triazine is bonded to a dibenzoxazole nitrogen atom
- Patent Document 4 discloses a compound in which a nitrogen-containing heteroaryl group such as a triazine is bonded to a nitrogen atom of benzoxazole as an organic electroluminescent compound
- Patent Document 5 discloses A compound in which a nitrogen-containing heteroaryl group such as a quinazoline is bonded to a nitrogen atom of a carbazole derivative as an organic electroluminescent compound.
- the above reference does not specifically disclose an organic electroluminescent compound which is introduced into the host material structure as an electron-defining group as a compound represented by the following formula (I) or (II).
- electron transport materials mostly have a high electron affinity and thus have a strong ability to accept electrons, but a common electron transport material such as AlQ 3 (octahydroxyquinoline aluminum) relative to a hole transport material.
- the electron mobility is much lower than the hole mobility of the hole transporting material, and thus the possibility of recombination of holes and electrons caused by the imbalance of carrier injection and transport in the OLED device is lowered, thereby reducing
- the luminous efficiency of the device on the other hand, electron transport materials with lower electron mobility can cause the operating voltage of the device to rise, thereby affecting power efficiency, which is disadvantageous for energy saving.
- LiQ doping into the ET material layer is widely used to achieve low voltage and high efficiency of the device.
- the role of LiQ is mainly to enable the electron injection effect to be significantly improved.
- lithium ions can increase the electron mobility of ET materials, so that LiQ-doped ET devices have low operating voltage and high luminous efficiency.
- Patent Document 1 International Patent Publication No. WO2006/049013
- Patent Document 2 U.S. Patent No. 8,227,798
- Patent Document 3 Korean Patent Application No. 10-2010-0108924
- Patent Document 4 Korean Patent No. 10-1074193
- Patent Document 5 International Patent Publication No. WO2012/121561
- Non-Patent Document 1 J. Appl. Phys., 2001, 90: 5048-5051; Appl. Phys. Lett., 2002, 80: 2308-2310.
- the object of the present invention to provide a class of fused heterocyclic derivatives which have a high glass transition temperature and a high melting point, thereby providing a class having a high glass transition temperature and a high melting point. At the same time, it has a compound with high carrier transport and luminous efficiency.
- the object of the present invention is to apply the derivative to the organic light-emitting functional layer as the host material of the light-emitting layer, and obtain an organic electroluminescent device with high thermal stability and long service life, thereby obtaining a high thermal stability.
- An organic electroluminescent device having a long life, a low driving voltage, and high luminous efficiency.
- another object of the present invention is to provide a kind of fused heterocyclic derivative which has good electron transporting property, and an organic electroluminescent device using such a compound has a lower operating voltage than the prior art.
- the luminous efficiency is high.
- the inventors of the present invention have intensively studied to propose a novel class of compounds usable for organic electroluminescent devices and devices using the same, which have high glass by introducing a structure of the formula (I) or (II).
- the conversion temperature and the high melting point simultaneously have good electron transport properties, thereby solving the above problems in the prior art.
- the compound of the present invention is represented by the following general formula (I) or (II):
- X is selected from CR 4 or N; and R 1 to R 4 are each independently selected from the group consisting of hydrogen, hydrazine, halogen, cyano, nitro, hydroxy, silane, substituted or unsubstituted C1-C12 alkyl, C1.
- a C12 alkoxy group a substituted or unsubstituted C5-C60 aryl or heteroaryl group
- the substituent of the C5-C60 aryl or heteroaryl group being selected from the group consisting of hydrazine, halogen, cyano, nitro, hydroxy a silyl group, an amino group, a substituted or unsubstituted C1-C12 alkyl group, a C1-C12 alkoxy group, a C6-C30 substituted or unsubstituted aryl group, a C10-C30 substituted or unsubstituted heteroaryl group, C6 a substituted or unsubstituted arylamino group of -C30, a substituted or unsubstituted heteroarylamino group of C3 to C30, a substituted or unsubstituted aryl group of C6 to C30, and a substituted or unsubstituted C10 to C30 group
- the substituent of the heteroaryl group is selected from the group consisting of phenyl, biphenyl, terphenyl, naphthyl and phenanthryl; the number of R 3 is 0 to 4, and when the number of R 3 is 2 or more, R 3 is the same.
- L 1 and L 2 are each independently selected from a single bond, -O-, -S-, -NR a -, C1-C5 alkylene, (C1-C3 alkylene)-O-(C1 ⁇ C3 alkylene), C6-C30 arylene, C3 ⁇ C30 Heteroarylene; the dotted line and Cy in the formula (II) represent a five- or six-membered aromatic or aromatic heterocyclic ring fused to a pyrimidine ring.
- a compound satisfying the above definition has good electron transport properties while having a high glass transition temperature and a high melting point.
- the principle is not clear, and it is presumed as follows:
- a pyrimidotriazole group (when X is N) or a pyrimidazolidinyl group (when X is CR 4 ) as a mother nucleus has a large
- the conjugated structure makes the glass transition temperature Tg of the compound greatly improved, and the organic electroluminescent material containing such a compound has high thermal and chemical stability, and thus is compared with the organic electroluminescent material of the prior art.
- the above compounds of the present invention have a very good coplanar conjugated structure, and the molecules can fully undergo ⁇ - ⁇ interaction between groups in a solid state, which facilitates electrons between material molecules.
- the transfer so that the material containing such compounds has a very high electron mobility, so the application of such materials in OLED devices is beneficial to reduce the operating voltage of the device and improve the luminous efficiency of the device.
- substitution bond of R 3 in the structural formula is directed to the expression of the center of the ring, indicating that the substitution position can be at any possible position of the ring.
- the expression of the substitution bond in the structural formula is similar.
- the expression of Ca to Cb means that the group has a number of carbon atoms a to b, and unless otherwise specified, the number of carbon atoms generally does not include the number of carbon atoms of the substituent.
- the alkyl group may be straight or branched.
- examples of the C1-C12 alkyl group include a methyl group, an ethyl group, a n-propyl group, an isopropyl group, a n-butyl group, a sec-butyl group, an isobutyl group, a t-butyl group, and a pentyl group.
- C1-C12 alkoxy group examples include a group obtained by linking the above-mentioned C1-C12 alkyl group to -O-, for example, a methoxy group, an ethoxy group, a propoxy group, a butoxy group, a pentyloxy group, or the like.
- C5-C60 aryl group examples include a phenyl group, a biphenyl group, a naphthyl group, an anthracenyl group, a phenanthryl group, a fluorenyl group and the like.
- a phenyl group, a naphthyl group, and more preferably a phenyl group are preferable; a C60 heteroaryl group which may be a nitrogen-containing heteroaryl group, an oxygen-containing heteroaryl group, a sulfur-containing heteroaryl group or the like, and specific examples thereof include a pyridyl group, a pyrimidinyl group, a pyrazinyl group, a pyridazinyl group, and the like.
- an aryl group, an arylene group, a heteroaryl group, a heteroarylene group or the like includes not only a single ring but also a fused ring.
- substituted or unsubstituted means, unless otherwise specified, substituted by one or more substituents selected from the group consisting of halogen, cyano, hydroxy, alkoxy, alkyl, aryl, hetero
- An aryl group preferably fluorine, cyano, methoxy, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, phenyl, biphenyl, naphthyl, Fenyl, fluorenyl, dibenzofuranyl, dibenzothiophenyl, pyridyl, quinolyl, phenylpyridyl, pyridylphenyl, etc.; or no substituent.
- the inventors of the present invention have found that by appropriately limiting the group of the compound of the present invention, it is possible to obtain a host material or an electron transport material which is more excellent in some aspects of performance.
- the details are as follows.
- a first preferred embodiment of the compound of the present invention relates to a compound which can be used as a host material and which is represented by the following general formula (I) or (II):
- X is selected from CR 4 or N; and R 1 to R 4 are each independently selected from hydrogen, C1-C10 alkyl, substituted or unsubstituted C5-C60 aryl or heteroaryl, said aryl or
- the substituent of the heteroaryl group is selected from the group consisting of hydrazine, fluorine, methyl, methoxy, cyano, phenyl, biphenyl, naphthyl, phenanthryl, pyridyl, furyl, thienyl, fluorenyl, benzofuran Benzo, benzothienyl, substituted or unsubstituted fluorenyl, dibenzofuranyl, dibenzothiophenyl, substituted or unsubstituted carbazolyl, benzoxazolyl, dibenzoxazolyl,
- the substituent of the fluorenyl group and the carbazolyl group is selected from the group consisting of a phenyl group
- a pyrimidotriazole group (when X is N) or a pyrimidazolidinyl group (when X is CR 4 ) as a mother nucleus has a large conjugated structure, so that the compound The glass transition temperature Tg is greatly improved, and the organic electroluminescent material containing such a compound has high thermal and chemical stability, and thus has a longer life than the organic electroluminescent material of the prior art.
- the five- or six-membered aromatic ring or aromatic heterocyclic ring is preferably selected from the group consisting of a benzene ring, a pyridine ring, a furan ring, and a thiophene ring.
- R 1 is preferably a structure represented by the following formula (III):
- L 3 is independently selected from the group consisting of a single bond, -O-, -S-, C1-C5 alkylene, (C1-C3 alkylene)-O-(C1-C3 alkylene), C6-C30 Arylene, C3 to C30 heteroarylene;
- R 5 and R 6 are independently selected from H, D, substituted or unsubstituted C1 to C12 alkyl, C1 to C12 alkoxy, halogen, cyano, a nitro group, a hydroxyl group, a silane group, a C6-C30 substituted or unsubstituted aryl group, a C10-C30 substituted or unsubstituted heteroaryl group;
- the number of R 5 and R 6 is 0 to 4, respectively, when R 5 Or when the number of R 6 is 2 or more, R 5 is the same or different, and R 6 is the same or different; or R 5 and R 6 are independently fused to the bonded benzene
- the aryl or heteroaryl group formed is optionally selected from 0 to 5 independently selected from substituted or unsubstituted C1 to C12 alkyl, halogen, cyano, nitro, hydroxy, silane, C6 to C30. Substituted by a substituted or unsubstituted aryl group, a C3 to C30 substituted or unsubstituted heteroaryl group; Y is C(R 7 ) 2 , NR 8 , O, S; n is equal to 0 or 1, when n It is 0, which represents two carbon atoms directly connected to the Y attached; R 7 and R 8 are independently selected from hydrogen C1 ⁇ C5 alkyl, phenyl, halo, cyano, nitro, hydroxy, two R 7 the same or different.
- R 1 in the above formula (I) or (II) to the structure represented by the above formula (III)
- a dibenzo nitrogen-containing heterocyclic group which can serve as an electron donor can be introduced into the molecule to The carrier transport is balanced to improve the performance of the organic electroluminescent device using the above compound as a host material, which has high luminance, high efficiency, and low driving voltage.
- n is preferably 0.
- a compound represented by the general formulae (I) and (II) having electron-deficient properties can be linked to a carbazole derivative group which can serve as an electron donor to form a receptor-donor molecule, thereby improving
- the energy gap and the triplet energy level of the molecule can obtain a bipolar phosphorescent host material with excellent performance, which makes the carrier transport on the molecule more balanced, thereby improving the brightness and efficiency of the organic electroluminescent device using the compound.
- the use of an organic functional layer of a bipolar material can make the device structure simple.
- L 3 is preferably a single bond or a phenylene group.
- L 3 is preferably a single bond or a phenylene group.
- a compound represented by the general formulae (I) and (II) having electron-deficient properties can be directly or permeated with a carbazole derivative group which can serve as an electron donor.
- the benzene ring is connected to further enhance its function as a bipolar host material.
- R 5 and R 6 are independently selected from hydrogen, a substituted or unsubstituted C1-C4 alkyl group, a phenyl group, a naphthyl group, a furyl group, a thienyl group, a pyrrolyl group, Pyridyl, biphenyl, terphenyl, naphthyl, anthracenyl, phenanthryl, anthracenyl, fluorenyl and its derivatives, fluoranthenyl, triphenylene, fluorenyl, fluorenyl, Tetraphenyl, triarylamine, 9,9-dimethylindenyl, distyrylphenyl, benzindenyl, indenyl or fluorenyl, or as shown in formula (V) a benzoheteroaryl group; or R 5 and R 6 are independently fused to a benzene ring to which they are attached
- the linking site is located on N in the formula (V) or on the benzene ring, and when the point of attachment is on the benzene ring in (V), N is bonded to the alkyl group of H, phenyl, C1 to C4; Is C(R 9 ) 2 , NR 10 , O, S; m is equal to 0 or 1, when m is 0, it means that two carbon atoms connected to X' are directly connected; R a , R b , R 9 and R 10 is independently selected from the group consisting of hydrogen, C1-C5 alkyl, C1-C5 alkoxy, halogen, cyano, nitro, hydroxy, phenyl, two R 9 being the same or different; X' is the same as or different from Y .
- R 2 to R 4 are each independently selected from the following groups:
- R 1 is one of the following groups:
- R 1 is one of the above groups
- carrier transport can be appropriately balanced, so that excitons are uniformly distributed, and carriers are avoided at the interface.
- the recombination reduces the quenching of the triplet-triplet state at high exciton concentrations.
- An organic electroluminescence device using a compound in which R 1 is one of the above groups has high luminance, high efficiency, and low driving voltage.
- R 1 is one of the following groups:
- R 1 is one of the above groups
- the performance of the above compound as a bipolar host material of a doped light-emitting device can be further improved, and the carrier transport can be further balanced to reduce the triplet state at a high exciton concentration.
- An organic electroluminescence device using a compound in which R 1 is one of the above groups can have higher brightness, efficiency, and lower driving voltage.
- the general formulae (I) and (II) are preferably such that when X is CR 4 , R 2 is hydrogen, and the general formulae (I) and (II) are more preferably selected from one of the following structures:
- R 1 to R 4 are selected from one of the combinations shown in Table 1 below.
- R 2 (R 4 ) in the second column of Table 1 is explained. Since the general formulae (I) and (II) are selected from one of the above structures, when X is N, R 4 does not exist at X. When it is CR 4 , R 2 is hydrogen, so one of R 2 and R 4 must have been determined. In order to make the table more concise, in Table 1, R 2 and R 4 are placed in the same column, and R 2 (R) is used. 4 ) indicates another.
- the fused heterocyclic derivative of the first preferred embodiment of the present invention has one, two or all of the following advantages:
- a fused heterocyclic derivative provided by the present embodiment which comprises a compound represented by the general formulae (I) and (II) having an electron-deficient property and a carbazole derivative group which can serve as an electron donor to form a receptor-
- the donor molecule is modified to increase the energy gap and triplet energy level of the molecule, thereby obtaining a bipolar phosphorescent host material with excellent performance.
- the pyrimidotriazole group or the quinazoline triazole group as a mother nucleus has a large conjugated structure, so that the glass transition temperature Tg of the compound is greatly improved, and such an organic electroluminescent material has Higher thermal and chemical stability.
- the compound of the present embodiment is used as a bipolar host material of a doped light-emitting device, carrier transport can be properly balanced, so that excitons are uniformly distributed, and carrier recombination at the interface is avoided. The quenching of the triplet-triplet state at high exciton concentrations. Moreover, an organic functional layer based on a bipolar material can make the device structure simple.
- the performance of the organic electroluminescent device can be greatly improved, so that it has high brightness and high efficiency. Low drive voltage and long service life.
- a second preferred embodiment of the compound of the present invention relates to a compound which can be used as a host material and is represented by the following formula (II):
- Cy is a benzene ring and X is N; and L 1 and L 2 are each independently selected from a single bond, -O-, -S-, -NR a -, C1-C5 alkylene group, (C1 to C3 sub- Alkyl)-O-(C1-C3 alkylene), C6-C30 arylene, C3-C30 heteroarylene; R 1 is represented by the following formula (IV), and R 2 and R 3 are each independently Selected from hydrogen, hydrazine, C1-C12 alkyl, C1-C12 alkoxy, halogen, cyano, nitro, hydroxy, silane, C6-C30 substituted or unsubstituted aryl, C3-C30 substitution Or an unsubstituted heteroaryl group; the number of R 3 is 0 to 4, and when the number of R 3 is 2 or more, R 3 is the same or different;
- R 5 and R 6 are independently selected from the group consisting of H, D, C1 to C12 alkyl, C1 to C12 alkoxy, halogen, cyano, nitro, hydroxy, silyl, amino, C6 to C30 substituted or not a substituted arylamino group, a C3 to C30 substituted or unsubstituted heteroarylamino group, a C6 to C30 substituted or unsubstituted aryl group, a C3 to C30 substituted or unsubstituted heteroaryl group; R 5 and R 6 The number is 0 to 4, and when the number of R 5 or R 6 is 2 or more, R 5 is the same or different, and R 6 is the same or different; or R 5 and R 6 are independently thickened with the attached benzene ring.
- a C9-C30 aryl or heteroaryl group is optionally selected from 0 to 5 independently selected from C1 to C12 alkyl, halogen, cyano, nitro, hydroxy, Substituted with a silane group, a C6-C30 substituted or unsubstituted aryl group, a C3 to C30 substituted or unsubstituted heteroaryl group;
- Y is C(R 7 ) 2 , NR 8 , O, S; Is 0 or 1; when n is 0, it means that two carbon atoms connected to Y are directly connected, and R 7 and R 8 are independently selected from hydrogen, C1-C5 alkyl, phenyl, halogen, cyano, Nitro, hydroxy; two R 7 are the same or different .
- n is preferably 0.
- L 2 is preferably a bond
- L 1 is a bond, benzene or naphthalene.
- R 5 and R 6 are independently selected from hydrogen, substituted or unsubstituted C 1 -C 4 alkyl, phenyl, naphthyl, furyl, thienyl, pyrrolyl, pyridyl, biphenyl, triple Phenyl, naphthyl, anthracenyl, phenanthryl, anthracenyl, fluorenyl and its derivatives, fluoranthenyl, triphenylene, fluorenyl, fluorenyl, Tetraphenyl, triarylamine, 9,9-dimethylindenyl, distyrylphenyl, benzindenyl, indenyl or fluorenyl, or as shown in formula (V) a benzoheteroaryl group; or R 1 and R 2 are independently fused to a benzene ring to which they are attached to form a naphthyl group, an anthracenyl group,
- the linking site is located on N in the formula (V) or on the benzene ring, and when the point of attachment is on the benzene ring in (V), N is bonded to the alkyl group of H, phenyl, C 1 -C 4 ;
- X' is C(R 9 ) 2 , NR 10 , O, S;
- m is 0 or 1; when m is 0, it means that two carbon atoms connected to X' are directly connected, R a , R b , R 9 and R 10 are independently selected from the group consisting of hydrogen, C1-C5 alkyl, C1-C5 alkoxy, halogen, cyano, nitro, hydroxy, phenyl; two R 9 are the same or different;
- X' is the same as Y Or different.
- R 2 is preferably selected from the group consisting of H, D, a substituted or unsubstituted C1-C4 alkyl group, a phenyl group, a phenyl group substituted with a furyl group, a thienyl group, a pyrrolyl group and/or a pyridyl group, a biphenyl group, Terphenyl, naphthyl, anthracenyl, phenanthryl, anthracenyl, fluorenyl and its derivatives, fluoranthenyl, triphenylene, fluorenyl, fluorenyl, Tetraphenyl, furyl, phenylfuranyl, thienyl, phenylthienyl, pyrrolyl, phenylpyrrolyl, pyridyl, phenylpyridyl, pyrazinyl, fluorenyl, indenyl , quino
- -L 2 -R 2 is preferably selected from one of the following formulas:
- the C1-C12 alkyl group is more preferably a C1-C4 alkyl group, preferably a methyl group, an ethyl group, an isopropyl group or a cyclohexyl group; and a C1-C12 alkoxy group, more preferably a C1-C4 alkane group.
- Specific examples of the oxy group include a methoxy group, an ethoxy group, a propoxy group, and an isopropoxy group.
- the quinazoline triazole derivative containing a substituted or unsubstituted arylamine group proposed in the present embodiment is a bipolar phosphorescent host material.
- bipolar materials are ideal host materials, because the organic functional layer based on bipolar materials not only makes the device structure simple, but also can properly balance the transport of carriers, so that the exciton is evenly distributed, avoiding The recombination of carriers at the interface reduces the quenching of the triplet-triplet state at high exciton concentrations.
- the electron-deficient receptor group and the electron-rich donor group are linked to form a receptor-donor molecule, which will increase the energy gap and triplet energy level of the molecule, thereby achieving higher Excellent bipolar phosphorescent host material with triplet and wide energy gap.
- the present embodiment connects a quinazoline triazole group having electron-deficient properties to a carbazole derivative group which can serve as an electron donor.
- These compounds have a large spatial structure and can avoid blending.
- the heterogeneous body is quenched in the stacking of energy, and the large spatial structure makes the glass transition temperature Tg of the material greatly improved.
- These materials also have high thermal and chemical stability.
- the organic electroluminescent device it can be used as a bipolar host material of a doped light-emitting device.
- the fused heterocyclic derivative provided by the present embodiment has a high glass transition temperature, a high melting point, and high carrier transport efficiency and luminous efficiency.
- an organic light-emitting functional layer as a host material of a light-emitting layer
- an organic electroluminescence device having a low driving voltage and high light-emitting efficiency can be obtained.
- the fused heterocyclic derivative of the present invention has one, two or all of the following advantages:
- a fused heterocyclic derivative according to the present invention which comprises a quinazoline triazole group having electron-deficient properties and a carbazole derivative group which can serve as an electron donor to form a receptor-donor molecule
- the energy gap and the triplet energy level of the molecule are improved, thereby obtaining a bipolar phosphorescent host material with excellent performance.
- the quinazoline triazole group as a mother nucleus has a large conjugated structure, so that the glass transition temperature Tg of the compound is greatly improved, and such an organic electroluminescent material has high thermal and chemical stability. .
- the carrier transport can be properly balanced, so that excitons are uniformly distributed, and carrier recombination at the interface is avoided, and the height is reduced. The quenching of the triplet-triplet state under exciton concentration.
- an organic functional layer based on a bipolar material can make the device structure simple.
- the compound of the formula (1) prepared by the present invention is used as a host material of a red phosphorescent emitting layer, the performance of the organic electroluminescent device can be greatly improved, so that it has high brightness, high efficiency, low driving voltage, and Long service life.
- the compound of the present invention can also be used in combination with a conventionally known light-emitting layer host material.
- a third preferred embodiment of the compound of the present invention relates to a compound which can be used as an electron transporting material, represented by the following general formula (I) or (II):
- X is selected from CR 4 or N; and R 1 to R 4 are each independently selected from hydrogen, C1-C10 alkyl, substituted or unsubstituted C5-C60 aryl or heteroaryl, said aryl or
- the substituent of the heteroaryl group is selected from the group consisting of hydrazine, fluorine, methyl, methoxy, cyano, phenyl, biphenyl, naphthyl, phenanthryl, substituted or unsubstituted fluorenyl, and substituents of the fluorenyl group Selected from phenyl, biphenyl, terphenyl, naphthyl, phenanthryl; the number of R 3 is 1; L 1 and L 2 are single bonds; the dotted line and Cy in the formula (II) represent a pyrimidine ring A fused five or six membered aromatic or aromatic heterocyclic ring.
- the groups of the commonly used electron transporting materials include a group such as pyridine, quinoline, phenanthroline, triazine or the like.
- the above compounds of the present embodiment employ a novel class of groups having strong electron affinity, and the Gaussian calculation results in a LUMO of the compound of the present invention of about -1.51 eV, which is significantly lower than a commonly used electron withdrawing group such as pyridine.
- the LUMO level of (-0.61 eV), quinoline (-1.38 eV), and phenanthroline (-1.41 eV) indicates that the compounds of the formula (I) and (II) have high electron affinity and are one.
- An excellent electron withdrawing group, a compound having such a substituent has good electron injecting properties.
- the mechanism by which the compound of the present embodiment has the above-mentioned good properties is inconclusive, it is presumed that this is because the compounds of the general formulae (I) and (II) have a very good coplanar conjugated structure, so that such substitution is possible.
- the compound molecules of the group can fully undergo ⁇ - ⁇ interaction between groups in the solid state, which facilitates the transfer of electrons between the molecules of the material, so that the material containing such a compound has a very high electron mobility.
- the application of such materials in OLED devices is advantageous for reducing the operating voltage of the device and improving the luminous efficiency of the device.
- the general formulae (I) and (II) are preferably such that when X is CR 4 , R 2 is hydrogen, and the general formulae (I) and (II) are more preferably selected from one of the following structures:
- R 1 ⁇ R 4 comprises at least one of an anthracene ring structure, the structure is more preferably R 1 ⁇ R 4, at least one of the following formula (VI) represented by:
- B is a substituted or unsubstituted fluorenyl group
- the substituent of the fluorenyl group is selected from the group consisting of a phenyl group, a biphenyl group, a terphenyl group, a naphthyl group, and a phenanthryl group.
- L is a single bond, a monocyclic arylene group having a carbon number of 5 to 10 or a monocyclic heteroarylene group, preferably a single bond, a monocyclic arylene group having 5 to 6 carbon atoms or a monocyclic heteroarylene group.
- the group is more preferably a single bond, a phenylene group or a pyridylene group.
- R 1 to R 4 By setting at least one of R 1 to R 4 as the above structure, the conjugated structure of the anthracene ring and the strong electron affinity can be better utilized, and the electron transport performance of the above compound can be improved.
- R 1 to R 4 which are not the structures represented by the general formula (VI) are each independently selected from the following groups:
- the structure represented by the formula (VI) is more preferably selected from one of the following groups:
- R 1 to R 4 are selected from one of the following Table 2.
- R 2 (R 4 ) in the second column of Table 2 is explained. Since the general formulae (I) and (II) are selected from one of the above structures, when X is N, R 4 does not exist at X. When it is CR 4 , R 2 is hydrogen, so one of R 2 and R 4 must have been determined. In order to make the table more concise, in Table 2, R 2 and R 4 are placed in the same column, and R 2 (R) is used. 4 ) indicates another.
- R 1 to R 4 as a combination in the above table, the conjugated structure of the anthracene ring can be more fully utilized, the LUMO of the above compound can be further reduced, the electron affinity of the above compound can be improved, and the above compound can be made good. Electronic injection performance.
- the compound of the present embodiment is closer to the work function of the cathode material due to the high electron affinity specific to the parent structure, so that the material can easily obtain electrons from the cathode and has strong electron injectability; Aspects of this material have high electron mobility.
- the materials of the present embodiment can realize the technical effects that can be realized by the commonly used ET with LiQ in the case of using the materials alone, thereby avoiding the use of LiQ which is sensitive to water and environment to match conventional ET materials.
- a fourth preferred embodiment of the compound of the present invention relates to a compound which can be used as an electron transporting material, represented by the following general formula (II):
- Cy is a benzene ring and X is N; and L 1 and L 2 are each independently selected from a single bond, -O-, -S-, -NR a -, C1-C5 alkylene group, (C1 to C3 sub- Alkyl)-O-(C1-C3 alkylene), C6-C30 arylene, C3-C30 heteroarylene; R 1 , R 2 , R 3 are each independently selected from H, substituted or not Substituted C1-C12 alkyl, C1-C12 alkoxy, halogen, cyano, nitro, hydroxy, silane, C6-C30 substituted or unsubstituted aryl, C3-C30 substituted or unsubstituted hetero
- the number of R 3 in the aryl group is 1 to 4, and when the number of R 3 is 2 or more, R 3 is the same or different, and at least one of R 1 and R 2 is a substituted or unsubstit
- R 1 and R 2 is a substituted or unsubstituted fused aryl group, the fused aryl group contains a fused ring formed by two or more benzene rings; and the thick
- the aryl group and the substituent thereon may form a conjugated ⁇ bond with L 1 or L 2 attached thereto, the conjugated ⁇ bond includes at least four benzene rings, or the fused aryl itself
- the conjugated ⁇ bond formed includes at least three benzene rings.
- R 1 and R 2 are selected from a substituted or unsubstituted naphthyl group, an anthracenyl group, a fluorenyl group, a fluorenyl group, a phenanthryl group, a fluorenyl group, a benzofluorenyl group, and a benzene group.
- substituent is 1 to 4 independently selected from H, substituted or unsubstituted C1 to C12 alkyl, C1 to C12 alkoxy, halogen, cyano, nitro, hydroxy, silane, a substituted or unsubstituted aryl group of C6 to C18 or a substituted or unsubstituted heteroaryl group of C3 to C11, which are the same or different.
- R 1 and R 2 are a naphthyl group or a group represented by the formula (VII), wherein * represents a linking site, and the formula (VII) is optionally 1 to 4 Substituted independently by a substituent selected from H, substituted or unsubstituted C1-C12 alkyl, C1-C12 alkoxy, phenyl, halogen, cyano, nitro, hydroxy, said substituents being the same or different;
- Ar 3 is selected from the group consisting of H, substituted or unsubstituted C1-C12 alkyl, C1-C12 alkoxy, halogen, cyano, nitro, hydroxy, C6-C12 substituted or unsubstituted aryl, C3 a substituted or unsubstituted heteroaryl group of -C11; when two Ar 3 are present in the formula (VII), the two Ar 3 are the same or different;
- L 1 and L 2 are independently a single bond, a phenyl group, a furyl group, a thienyl group, a pyrrolyl group, a pyridyl group, a biphenyl group, a terphenyl group, or a naphthyl group.
- the Ar 3 is independently selected from the group consisting of hydrogen, phenyl, naphthyl, furyl, thienyl, pyrrolyl, pyridyl, biphenyl, terphenyl, naphthyl, anthracenyl, phenanthryl , mercapto, fluorenyl and its derivatives, fluoranthene, triphenylene, fluorenyl, fluorenyl, And tetraphenyl, triarylamine, 9,9-dimethylindenyl, distyrylphenyl, benzindenyl, indenyl or fluorenyl.
- R 1 and R 2 are a naphthyl group or a group represented by the formula (VII), it is preferred that the other one is hydrogen, phenyl, naphthyl, furyl, thienyl, pyrrolyl.
- pyridyl biphenyl, terphenyl, naphthyl, anthracenyl, phenanthryl, anthracenyl, fluorenyl and its derivatives, fluoranthenyl, triphenylene, fluorenyl, fluorenyl, And tetraphenyl, triarylamine, 9,9-dimethylindenyl, distyrylphenyl, benzindenyl, indenyl or fluorenyl.
- Preferred structures of the compounds involved in the present embodiment are as follows, but are not limited to these compounds.
- the groups of commonly used electron transporting materials include groups such as pyridine, quinoline, phenanthroline and triazine.
- the compounds in the scheme employ a novel class of groups with strong electron affinity: quinazoline and triazole, Gauss calculated that the quinazoline and triazole parent compound has a LUMO of about -1.651 eV.
- the compound of the present embodiment is closer to the work function of the cathode material due to the high electron affinity specific to the parent structure, so that the material can easily obtain electrons from the cathode and has strong electron injectability; Aspects of this material have high electron mobility.
- the material of the present invention can realize the technical effects that the commonly used ET can be combined with QLi in the case of using the material alone, thereby avoiding the use of water and environment sensitive QLi to match the conventional ET material, such that In the screen production line, the use of materials is reduced, which is beneficial to reduce material costs.
- the number of evaporation sources of mass production equipment can be reduced, thereby reducing the design and manufacturing cost and process complexity of the equipment. The meaning.
- the inventors have also found that when the quinazoline triazole compound is substituted by a thiol group, it has a very suitable HOMO, LUMO energy level, and the resulting compound is suitable for electron and hole transport channels, and has a higher
- the charge transport properties which may be related to the distribution of HOMO and LUMO on the thiol functional group.
- the mercapto functional group can impart reversible electrochemical redox characteristics to the compound, which makes the compound of the present invention containing a mercapto functional group exhibit excellent electron transport properties, and thus an electron transport material as a device is preferable.
- the invention also provides the use of the above compounds in organic electroluminescent devices.
- the above compounds can be used as, but not limited to, an electron transporting material or a light emitting layer host material.
- the present invention also provides an organic electroluminescent device comprising a first electrode, a second electrode, and one or more organic layers between the first electrode and the second electrode, wherein the organic At least one of the above compounds is included in the layer.
- the organic layer between the first electrode and the second electrode usually includes an organic layer such as an electron injection layer, an electron transport layer, a light-emitting layer, a hole transport layer, and a hole injection layer.
- the organic layer includes a hole transporting layer, an organic light emitting layer, and an electron transporting layer, the organic light emitting layer comprising a host material and a dopant dye, and the host material of the organic light emitting layer is selected from the above Compound. More preferably, the dopant material is a red phosphorescent dye.
- the organic layer contains an electron injecting layer, the electron injecting layer contains the compound, and it is preferable that the organic layer contains an electron transporting layer, and the electron transporting layer contains the above compound.
- the compound of the present embodiment can be applied to an organic electronic device such as an organic electroluminescence device, a lighting element, an organic thin film transistor, an organic field effect transistor, an organic thin film solar cell, an information tag, an electronic artificial skin sheet, and a sheet.
- an organic electronic device such as an organic electroluminescence device, a lighting element, an organic thin film transistor, an organic field effect transistor, an organic thin film solar cell, an information tag, an electronic artificial skin sheet, and a sheet.
- Large area sensors such as material scanners, electronic paper, and organic EL panels.
- an organic functional layer based on a bipolar material can make the device structure simple.
- the organic electroluminescent device substrate of the present embodiment may use a substrate in a conventional organic light-emitting device, such as glass or plastic, preferably a glass substrate.
- the anode material may be a transparent highly conductive material such as indium tin oxide (ITO), indium zinc oxide (IZO), tin dioxide (SnO 2 ), zinc oxide (ZnO) or the like.
- ITO indium tin oxide
- IZO indium zinc oxide
- SnO 2 tin dioxide
- ZnO zinc oxide
- ITO is used as the anode material in the device of the present invention.
- the thickness of the hole transport layer is generally from 5 nm to 5 ⁇ m, and the hole transport layer may be N,N'-bis(3-methylphenyl)-N,N'-diphenyl-[1,1 -biphenyl]-4,4'-diamine (TPD) or N,N'-diphenyl-N,N'-bis(1-naphthyl)-(1,1'-biphenyl)- A triarylamine material such as 4,4'-diamine (NPB).
- TPD N,N'-bis(3-methylphenyl)-N,N'-diphenyl-[1,1 -biphenyl]-4,4'-diamine
- NPD N,N'-diphenyl-N,N'-bis(1-naphthyl)-(1,1'-biphenyl)-
- a triarylamine material such as 4,4'-diamine (NPB).
- the device structure may be a single light emitting layer or a multiple light emitting layer structure; each light emitting layer may be a single light emitting light emitting material structure or a doped structure; the light emitting dopant may be selected from a phosphorescent material; Such as red, yellow, blue, green and so on.
- the cathode may be made of a metal or a mixture thereof, such as Mg:Ag, Ca:Ag, or the like, or may be an electron injecting layer/metal layer structure such as a common cathode structure such as LiF/Al or Li 2 O/Al.
- the electron injecting layer may be a simple substance, a compound or a mixture of an alkali metal, an alkaline earth metal, a transition metal, or a composite cathode structure composed of a multilayer material.
- an organic electroluminescent device includes a multilayer organic functional layer interposed between a cathode and an anode, including a hole transport layer, a light emitting layer, an electron transport layer, an electron injection layer, and the like.
- a manufacturing method and general compositions are also applicable to the present invention.
- the intermediate preparations involved in the first preferred embodiment and the third preferred embodiment of the present application can be roughly classified into two types, one being a pyrimidine (derivative) and a triazole intermediate M1, and the other being a pyrimidine (derivative). And an imidazole intermediate M2.
- the preparation method is as follows:
- N-phenylcarbazole-3-boronic acid 500 g, 1.742 mol
- 3-bromocarbazole (412 g, 1.584 mol)
- potassium carbonate 656 g, 4.752 mol
- toluene:ethanol:water 3 L, 1 L
- tetrakistriphenylphosphine palladium 18.3 g, 0.016 mol
- 2,4-Dichloroquinazoline 500 g, 2.5 mol
- hydrazine hydrate 470 g, 7.5 mol, 80% aqueous solution
- the mixture was allowed to react to room temperature for 1 hour, and the obtained solid was filtered, and the solid was washed with water and ethanol, and dried to give the white solid compound 8-1 (415 g, 86%).
- the compound 8-3 (7 g, 25 mmol), the compound 1-4 (10 g, 23.64 mmol), potassium carbonate (10 g, 72.46 mmol) was added to a flask containing 200 mL of acetonitrile, and the mixture was heated under reflux with stirring for 12 hours under nitrogen atmosphere, TLC showed The reaction is complete. 200 mL of water was added and the resulting pale yellow solid was filtered. The organic layer was dissolved in methylene chloride (MgSO4). Molecular weight calculated: 652.24, found m/Z: 652.2.
- the compound 15-2 (5.6 g, 20 mmol), the compound 3-2 (5.5 g, 20 mmol), potassium carbonate (8.3 g, 60 mmol) was added to a flask containing 200 mL of acetonitrile, and the mixture was heated under reflux with stirring for 12 hours under nitrogen atmosphere, TLC. The reaction is shown to be complete. 200 mL of water was added and the resulting pale yellow solid was filtered. The mixture was dissolved in dichloromethane, dried over anhydrous sodium sulfate, and then purified to afford white crystals of compound 6BI-63 (8.6 g, yield 86%). Molecular weight calculated: 501.16, found m/Z: 501.2.
- the compound 20-2 (5.7 g, 20 mmol), the compound 1-4 (8.46 g, 20 mmol), potassium carbonate (8.3 g, 60 mmol) was added to a flask containing 200 mL of acetonitrile, and the mixture was heated under reflux with stirring for 15 hours under nitrogen atmosphere, TLC The reaction is shown to be complete. 200 mL of water was added and the resulting pale yellow solid was filtered. The residue was dissolved in dichloromethane, dried over anhydrous sodium Molecular weight calculated: 657.20, found m/Z: 657.2.
- 2,4-Dichloroquinazoline 500 g, 2.5 mol
- hydrazine hydrate 470 g, 7.5 mol, 80% aqueous solution
- the mixture was allowed to react to room temperature for 1 hour, and the obtained solid was filtered with suction, and the solid was washed with water and ethanol, and dried to give the white solid compound 1-1 (415 g, 86%).
- N-phenylcarbazole-3-boronic acid 500 g, 1.742 mol
- 3-bromocarbazole (412 g, 1.584 mol)
- potassium carbonate 656 g, 4.752 mol
- toluene:ethanol:water 3 L, 1 L
- tetrakistriphenylphosphine palladium 18.3 g, 0.016 mol
- the compound 1-3 (7 g, 25 mmol), the compound 1-4 (10 g, 23.64 mmol), potassium carbonate (10 g, 72.46 mmol) was added to a flask containing 200 mL of acetonitrile, and the mixture was heated under reflux with stirring for 12 hours under nitrogen atmosphere, TLC showed The reaction is complete. 200 mL of water was added and the resulting pale yellow solid was filtered. The organic layer was dissolved in EtOAc (EtOAc m. Molecular weight calculated: 652.24, found m/Z: 652.2.
- Phenylboronic acid (1.85 g, 15.2 mmol), compound 7-4 (11.1 g, 15.2 mmol), potassium carbonate (6.3 g, 45.6 mmol) in 1,4-dioxane/water (300 mL/100 mL)
- the flask was replaced with nitrogen under stirring at room temperature, and tetrakistriphenylphosphine palladium (176 mg, 0.152 mmol) was added. After the addition, the reaction was stirred for 8 hours, and the reaction was monitored by TLC. The precipitated solid was filtered. The liquid phase was separated, and the aqueous phase was extracted with methylene chloride. The organic phase was combined, dried over anhydrous sodium sulfate, filtered and evaporated.
- the compound 10-3 (8 g, 18.8 mmol), the compound 9-2 (7 g, 19.7 mmol), potassium carbonate (7.8 g, 56.4 mmol) was added to a flask containing 200 mL of acetonitrile, and the mixture was heated under reflux with stirring for 15 hours under a nitrogen atmosphere. TLC showed the reaction was complete. 200 mL of water was added and the resulting pale yellow solid was filtered. The organic layer was dissolved in methylene chloride (MgSO4). Molecular weight calculated: 745.23, found m/Z: 745.2.
- Phenylboronic acid (1.65 g, 13.56 mmol), compound 3-4 (10.2 g, 13.56 mmol), potassium carbonate (5.6 g, 40.7 mmol) was added to a flask containing 1,4-dioxane/water (150 mL / 50 mL)
- the Pd(PPh 3 ) 4 (157 mg, 0.136 mmol) was added after replacing nitrogen with stirring at room temperature. After the addition, the reaction was stirred for 8 hours, and the reaction was monitored by TLC.
- the precipitated solid was filtered. The liquid phase was separated, and the aqueous phase was extracted with methylene chloride. The organic phase was combined, dried over anhydrous sodium sulfate, filtered and evaporated.
- the crude solid was combined and purified by column chromatography (eluent eluting dichloromethane) to afford compound C26 (7.1 g, yield 70%). Molecular weight calculated: 750.28, found C/Z: 750.3.
- organic electroluminescent materials are all materials commonly used in the art, and can be prepared by themselves or commercially purchased by those skilled in the art based on known methods.
- the glass plate coated with the ITO (120 nm) transparent conductive layer was sonicated in a commercial cleaning agent, rinsed in deionized water, and ultrasonically degreased in an acetone:ethanol mixed solvent (1:1 by volume) in a clean environment. Bake to complete removal of water, wash with UV light and ozone, and bombard the surface with a low energy cation beam from Satella (ULVAC);
- the glass substrate with the anode was placed in a vacuum chamber, evacuated to 1 ⁇ 10 -5 to 9 ⁇ 10 ⁇ 3 Pa, and the compound HI-1 was vacuum-deposited on the anode layer film to form a thickness of 80 nm.
- a hole injection layer 1; a compound HI-2 was vacuum-deposited on the hole injection layer 1 to form a hole injection layer 2 having a thickness of 5 nm; and a compound HT-1 was vacuum-deposited on the hole injection layer 2 to form a thickness.
- the compound C1 as the main body of the light-emitting layer was placed in a unit of a vacuum vapor deposition apparatus, and the compound D-1 as a dopant was placed in another unit of the vacuum vapor deposition apparatus, and the two materials were simultaneously evaporated at different rates, D
- the mass ratio of -1 to the host material compound 1I-12 is 3:97, and the total film thickness of the vapor deposition is 40 nm; then the compound ET-1 and the compound LiQ are respectively placed in two units of the vacuum vapor deposition apparatus to be 1:
- the ratio of 1 is evaporated, and each of the deposition is 50 Wt% of the doping amount on the luminescent layer
- An electron transport layer having a thickness of 40nm.
- an Al cathode having a thickness of 80 nm was deposited on the electron injecting layer by another vacuum vapor deposition apparatus. Thereby forming an OLED device.
- all materials used to make the OLED device were purified by vacuum sublimation purification equipment at 10-6 torr.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 1II-12.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 1II-63.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 1II-327.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 2I-12.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 2II-63.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 2II-327.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 3I-12.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 3I-327.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 3II-327.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 4I-12.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 4II-327.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 4I-63.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 5BII-327.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 6BI-12.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 6BI-63.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 7AII-327.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 8AI-12.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 9AII-327.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound 10AI-12.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with the compound CBP.
- An organic electroluminescent device was obtained in the same manner as in Example 1-1, except that the host material compound 1I-12 was replaced with a reference compound H-1 which is commonly used in the industry.
- the driving voltage and current efficiency of the organic electroluminescent devices prepared in the device examples 1-1 to 1-20 and the device comparative examples 1-1 to 1-2 were measured using a digital source meter and a luminance meter at the same brightness and The life of the device. Specifically, the voltage is raised at a rate of 0.1 V per second, and the voltage when the luminance reaches 1000 cd/m 2 , that is, the driving voltage is measured, and the current density at this time is measured; the ratio of the luminance to the current density is the current efficiency; T95
- the life test was performed using a luminance meter at a luminance of 5000 cd/m 2 , and a constant current was measured, and the time at which the luminance was lowered to 4,750 cd/m 2 was measured in hours. The results of the measurement results are shown in Table 4.
- the device embodiments 1-1 to 1-20 are different from the device comparative example 1-1 in that the device is implemented.
- Examples 1-1 to 1-20 used the series of compounds of the present embodiment instead of the comparative device Comparative Example 1-1 as the red light host material. Since the material itself has both an electron-donating group and an electron-withdrawing group, the material has good double-carrier transport performance, and can effectively broaden the exciton recombination region, so that the quenching between the triplet excitons is significantly reduced.
- the luminous efficiency can be effectively improved, and the device data shows that using the material of the embodiment as the main material of the light-emitting layer can reduce the operating voltage of the device and the high current efficiency, thereby demonstrating the excellent carrier transport balance of the material in the embodiment and Energy level matching.
- the novel organic material of the present embodiment was used for the host material in the organic electroluminescence device, and the voltage thereof was reduced by 50% or more with respect to CBP as a host material. At the same time, it has better voltage-current-luminous characteristics and higher efficiency. In particular, the lifetime of the device is significantly improved compared to the device lifetime in the device comparison example 1.
- the novel organic material of the present embodiment is used for the host material in the organic electroluminescent device, and the voltage is equivalent or reduced with respect to H-1 as the host material, and the efficiency and lifetime are also different. The degree of improvement.
- organic electroluminescent materials are all materials commonly used in the art, and can be prepared by themselves or commercially purchased by those skilled in the art based on known methods.
- the glass plate coated with the ITO (120 nm) transparent conductive layer was sonicated in a commercial cleaning agent, rinsed in deionized water, and ultrasonically degreased in an acetone:ethanol mixed solvent (1:1 by volume) in a clean environment. Bake to complete removal of water, wash with UV light and ozone, and bombard the surface with a low energy cation beam from Satella (ULVAC);
- the glass substrate with the anode was placed in a vacuum chamber, evacuated to 1 ⁇ 10 -5 to 9 ⁇ 10 ⁇ 3 Pa, and the compound HI-1 was vacuum-deposited on the anode layer film to form a thickness of 80 nm. a first hole injecting layer; vacuum-depositing the compound HI-2 over the first hole injecting layer to form a second hole injecting layer having a thickness of 5 nm; and vacuum-decomposing the compound HT on the second hole injecting layer 1.
- the luminescent layer is specifically operated by placing the compound C1 as the main body of the luminescent layer in a unit of a vacuum vapor deposition apparatus, and placing the compound D-1 as a dopant in another unit of the vacuum vapor deposition apparatus, which is different.
- the two materials were simultaneously evaporated at a rate, the mass ratio of D-1 to the host material compound C1 was 3:97, and the total thickness of the vapor deposited film was 40 nm; then the compound ET-1 and the compound EI-1 were respectively placed in a vacuum vapor deposition apparatus. Evaporation in a ratio of 1:1 in two units, and each deposition A doping amount of 50 Wt% was to form an electron transport layer having a thickness of 40 nm on the light-emitting layer.
- an Al cathode having a thickness of 80 nm was deposited on the electron injecting layer by another vacuum vapor deposition apparatus. Thereby forming an OLED device.
- all materials used to make OLED devices were purified by vacuum sublimation purification equipment at 10 -6 torr.
- An organic electroluminescent device was obtained in the same manner as in Example 2-1, except that the host material compound C1 was replaced with the compound C2.
- An organic electroluminescent device was obtained in the same manner as in Example 2-1, except that the host material compound C1 was replaced with the compound C12.
- An organic electroluminescent device was obtained in the same manner as in Example 2-1, except that the host material compound C1 was replaced with the compound C25.
- An organic electroluminescent device was obtained in the same manner as in Example 2-1, except that the host material compound C1 was replaced with the compound C29.
- An organic electroluminescent device was obtained in the same manner as in Example 2-1, except that the host material compound C1 was replaced with the compound C32.
- An organic electroluminescent device was obtained in the same manner as in Example 2-1, except that the host material compound C1 was replaced with the compound C33.
- An organic electroluminescent device was obtained in the same manner as in Example 2-1, except that the host material compound C1 was replaced with the compound C36.
Abstract
本发明提供一种化合物,由以下通式(I)或(II)表示: (I), (II) 其中,X选自CR4或N;R1~R4分别独立地选自氢、氘、卤素、氰基、硝基、羟基、硅烷基、取代或未取代的C1~C12的烷基、C1~C12烷氧基、取代或未取代的C3~C60的芳基或杂芳基;R3的数量为0~4个,当R3的数量为2个以上时,R3相同或者不同;L1和L2分别独立地选自单键、-O-、-S-、-NRa-、C1~C5的亚烷基、(C1~C3亚烷基)-O-(C1~C3亚烷基)、C6~C30的亚芳基、C3~C30的亚杂芳基;通式(II)中的虚线和Cy表示与嘧啶环稠合的五元或六元的芳环或芳杂环。该化合物可作为主体材料或电子传输材料用于有机电致发光器件中。本发明还提供了一种包含上述化合物的有机电致发光器件。
Description
本发明涉及一类有机化合物以及使用了该化合物的有机电致发光器件。
近年来,随着OLED技术在照明和显示两大领域的不断推进,人们对于其核心材料的研究更加关注,一个效率好寿命长的有机电致发光器件通常是器件结构以及各种有机材料的优化搭配的结果。常见的功能化有机材料有:空穴注入材料、空穴传输材料、电子注入材料、电子传输材料以及发光主体材料和发光客体(染料)等。为了制备性能更好的发光器件,业界一直致力于开发新的有机电致发光材料以进一步提高器件的发光效率和寿命。
在经典的磷光OLED器件中,磷光染料通常不单独作为发光层,而是将其掺杂在合适的主体材料中,形成主客体发光体系,以削弱三线态激子的高浓度猝灭效应。为了实现有效的能量传递,通常要求主体材料的能隙大于染料、且三线态能级ET要高于染料分子的三线态能级ET。这样才能顺利把T1态能量从主体材料传递至磷光染料或将三线态激子限制于染料分子中,从而实现高效率的磷光发射。此外,主体材料的玻璃化转变温度Tg关系到材料的成膜性和热稳定性。Tg温度低的材料热稳定性差且容易结晶或团聚,将大大降低器件的寿命,严重降低器件效率。
CBP是一种广为使用的磷光主体材料,有报道使用其作为主体,BCP,BAlq等作为空穴阻挡材料获得高效率的OLED器件。日本先锋公司等也曾有使用BAlq衍生物作为主体材料获得高效率OLED器件报道。
专利文献1公开了一种使用稠双环基团作为骨架结构的化合物;专利文献2和专利文献3公开了一种化合物,其中含氮杂芳基诸如三嗪键合到二苯并咔唑氮原子上作为有机电致发光化合物;专利文献4公开了一种化合物,其中含氮杂芳基诸如三嗪键合到苯并咔唑的氮原子上作为有机电 致发光化合物;专利文献5公开了一种化合物,其中含氮杂芳基诸如喹唑啉键合到咔唑衍生物氮原子上作为有机电致发光化合物。然而,上述参考文献没有具体公开后述通式(I)或(II)代表的化合物作为缺电子基团引入主体材料结构中的有机电致发光化合物。
另一方面,电子传输材料大多具有较高的电子亲和势,因而有较强的接受电子的能力,但是相对于空穴传输材料,常见的电子传输材料例如AlQ
3(八羟基喹啉铝)的电子迁移率要远低于空穴传输材料的空穴迁移率,因而在OLED器件中一方面会导致载流子的注入和传输不均衡而导致的空穴与电子的复合几率降低,从而降低器件的发光效率,另一方面具有较低电子迁移率的电子传输材料会导致器件的工作电压升高,从而影响功率效率,对能源的节约不利。
在目前OLED屏体厂商中,广泛使用LiQ掺杂到ET材料层中的技术手段来实现器件的低电压和高效率。LiQ的作用主要在于能够使电子的注入效果显著提升,另一方面,锂离子能提高ET材料电子迁移率,从而使LiQ掺杂ET的器件具有低的工作电压和高的发光效率。
现有技术文献
专利文献
专利文献1:国际专利公开WO2006/049013号
专利文献2:美国专利8,227,798号
专利文献3:韩国专利申请10-2010-0108924号
专利文献4:韩国专利10-1074193号
专利文献5:国际专利公开WO2012/121561号
非专利文献
非专利文献1:J.Appl.Phys.,2001,90:5048-5051;Appl.Phys.Lett.,2002,80:2308-2310.
发明内容
尽管上述的传统主体材料具有较好的光电性能,但其较低的玻璃化转变温度且热稳定性较差,导致器件在使用过程中性能下降。另外,使用BAlq、CBP或者类似材料用作磷光主体材料,由于工作电压高导致这类OLED器件在功率效率上并没有明显提高,且器件寿命较短。如上所述,现有材料仍有不足之处,开发具有高热稳定性和高光电性能的新型主体材料具有很重要的实际应用价值。
鉴于此,本发明的一个目的在于提供一类稠杂环衍生物,这类化合物具有高的玻璃化转变温度和高的熔点,进而提供一类在具有高的玻璃化转变温度和高的熔点的同时还具有高的载流子传输及发光效率的化合物。本发明的目的还在于将该类衍生物应用于有机发光功能层作为发光层的主体材料,得到一种热稳定性高、寿命长的有机电致发光器件,进而得到一种热稳定性高、寿命长且驱动电压低、发光效率高的有机电致发光器件。
另一方面,业界常用的ET搭配LiQ的技术方案仍存在不足之处。一方面,LiQ对水和环境敏感导致工艺复杂性提高,不利于设备的设计制造成本的降低;另一方面,材料的使用种类较多,不利于材料成本的降低。为了解决上述问题,进一步满足对OLED器件的光电性能不断提升的需求,以及移动化电子器件对于节能的需求,需要开发新型的、高效的OLED材料,尤其是开发新的具有高迁移率的电子传输材料。
鉴于此,本发明的另一个目的在于提供一类稠杂环衍生物,其具有良好的电子传输性能,与现有技术相比,使用了这类化合物的有机电致发光器件的工作电压较低,发光效率较高。
本发明的发明人经过深入研究,提出一类新型的可用于有机电致发光器件的化合物和使用该化合物的器件,该化合物通过引入通式(I)或(II)结构,在具有高的玻璃化转变温度和高的熔点的同时,还具有良好的电子传输性能,从而解决了现有技术中存在的上述问题。具体而言,本发明的化合物由以下通式(I)或(II)表示:
其中,X选自CR
4或N;R
1~R
4分别独立地选自氢、氘、卤素、氰基、硝基、羟基、硅烷基、取代或未取代的C1~C12的烷基、C1~C12烷氧基、取代或未取代的C5~C60的芳基或杂芳基,所述C5~C60的芳基或杂芳基的取代基选自氘、卤素、氰基、硝基、羟基、硅烷基、氨基、取代或未取代的C1~C12烷基、C1~C12烷氧基、C6~C30的取代或未取代的芳基、C10~C30的取代或未取代的杂芳基、C6~C30的取代或未取代的芳基氨基、C3~C30的取代或未取代的杂芳基氨基,所述C6~C30的取代或未取代的芳基和所述C10~C30的取代或未取代的杂芳基的取代基选自苯基、联苯基、三联苯基、萘基、菲基;R
3的数量为0~4个,当R
3的数量为2个以上时,R
3相同或者不同; L
1和L
2分别独立地选自单键、-O-、-S-、-NR
a-、C1~C5的亚烷基、(C1~C3亚烷基)-O-(C1~C3亚烷基)、C6~C30的亚芳基、C3~C30的亚杂芳基;通式(II)中的虚线和Cy表示与嘧啶环稠合的五元或六元的芳环或芳杂环。
本发明的发明人发现,满足上述限定的化合物在具有高的玻璃化转变温度和高的熔点的同时,还具有良好的电子传输性能。其原理尚不明确,推测如下:在本发明的上述化合物中,作为母核的嘧啶并三氮唑基团(X为N时)或嘧啶并咪唑基团(X为CR
4时)具有较大的共轭结构,使得化合物的玻璃化转变温度Tg大大提高,包含这样的化合物的有机电致发光材料具有较高的热及化学稳定性,因此与现有技术中的有机电致发光材料相比寿命更长;另一方面,本发明的上述化合物具有非常好的共平面的共轭结构,其分子在固态下能够充分发生基团间的π-π相互作用,有利于电子在材料分子间的传递,从而使得含有这类化合物的材料具有非常高的电子迁移率,因此这类材料应用在OLED器件中有利于降低器件的工作电压,提高器件的发光效率。
这里需要说明的是,结构式中R
3的取代键指向环中央的表达方式,表示取代位置可以在环的任意可能位置。结构式中取代键的表达的意思均与之类似。Ca~Cb的表达方式代表该基团具有的碳原子数为a~b,除非特殊说明,一般而言该碳原子数不包括取代基的碳原子数。
在本说明书中,烷基可以为直链或支链的。若无特别说明,作为C1~C12烷基的例子可举出:甲基、乙基、正丙基、异丙基、正丁基、仲丁基、异丁基、叔丁基、戊基、异戊基、己基、庚基、辛基、壬基、癸基、十一烷基、十二烷基等,其中优选甲基、乙基、正丙基、异丙基,更优选甲基;作为C1~C12烷氧基,可举出上述C1~C12烷基的例子与-O-连接得到的基团,例如甲氧基、乙氧基、丙氧基、丁氧基、戊氧基、己氧基、庚氧基、辛氧基、壬氧基、癸氧基、十一烷氧基、十二烷氧基等,其中优选甲氧基、乙氧基、丙氧基、更优选甲氧基;作为C5~C60芳基的例子可举出:苯基、联苯基、萘基、蒽基、菲基、芴基等,其中优选苯基、萘基、更优选苯基;作为C5~C60杂芳基,其可为含氮杂芳基、含氧杂芳基、含硫杂芳基等,具体的例如可举出:吡啶基、嘧啶基、吡嗪基、哒嗪基、三嗪基、喹啉基、异喹啉基、萘啶基、酞嗪基、喹喔啉基、喹唑啉基、菲啶基、吖啶基、菲咯啉基、吡咯基、咪唑基、吡唑基、三唑基、四唑基、吲哚基、苯并咪唑基、吲唑基、咪唑并吡啶基、苯并三唑基、咔唑基、呋喃基、噻吩基、噁唑基、噻唑基、异噁唑基、异噻唑基、噁二唑基、噻二唑基、苯并呋喃基、苯并噻吩基、苯并噁唑基、苯并噻唑基、苯并异噁唑基、苯并异噻唑基、苯并噁二唑基、苯并噻二唑基、二苯并呋喃基、二苯并噻吩基、哌啶基、吡咯烷基、哌嗪基、吗啉基、吩嗪基、吩噻嗪基、吩噁嗪基等,其中优选吡啶基、喹啉基、二苯并呋喃基、二苯并噻吩基,更优选吡啶基。
在本说明书中,若无特别说明,芳基、亚芳基、杂芳基、亚杂芳基等均不仅包括单环的情况,也包括稠环的情况。杂原子,通常指选自B、N、O、S、P、P(=O)、Si和Se中的原子或原子团。
在本说明书中,若无特别说明,表述“取代或未取代的”表示被一个或多个选自以下的取代基取代:卤素、氰基、羟基、烷氧基、烷基、芳基、杂芳基,优选为氟、氰基、甲氧基、甲基、乙基、正丙基、异丙基、正丁基、异丁基、叔丁基、苯基、联苯基、萘基、菲基、芴基、二苯并呋喃基、二苯并噻吩基、吡啶基、喹啉基、苯基吡啶基、吡啶基苯基等;或者没有取代基。
本发明的发明人发现,通过对本发明的化合物的基团进行适当的限定,能够得到某一方面的性能更加优异的主体材料或电子传输材料。现具体说明如下。
本发明的化合物的第一优选实施方案涉及一种化合物,其可用作主体材料,由以下通式(I)或(II)表示:
其中,X选自CR
4或N;R
1~R
4分别独立地选自氢、C1~C10的烷基、取代或未取代的C5~C60的芳基或杂芳基,所述芳基或杂芳基的取代基选自氘、氟、甲基、甲氧基、氰基、苯基、联苯基、萘基、菲基、吡啶基、呋喃基、噻吩基、茚基、苯并呋喃基、苯并噻吩基、取代或未取代的吲哚基、二苯并呋喃基、二苯并噻吩基、取代或未取代的咔唑基、苯并咔唑基、二苯并咔唑基,所述吲哚基和咔唑基的取代基选自苯基、联苯基、萘基、菲基,R
3的数量为1个,L
1和L
2为单键;通式(II)中的虚线和Cy表示与嘧啶环稠合的五元或六元的芳环或芳杂环。
在本发明提供的上述化合物中,作为母核的嘧啶并三氮唑基团(X为N时)或嘧啶并咪唑基团(X为CR
4时)具有较大的共轭结构,使得化合物的玻璃化转变温度Tg大大提高,包含这样的化合物的有机电致发光材料具有较高的热及化学稳定性,因此与现有技术中的有机电致发光材料相比寿命更长。
在上述化合物中,上述通式(I)或(II)中,五元或六元的芳环或芳杂环优选选自苯环、吡啶环、呋喃环、噻吩环。
在上述化合物中,上述通式(I)或(II)中,R
1优选为以下通式(III)表示的结构:
其中,L
3独立地选自单键、-O-、-S-、C1~C5的亚烷基、(C1~C3亚烷基)-O-(C1~C3亚烷基)、C6~C30的亚芳基、C3~C30的亚杂芳基;R
5和R
6独立地选自H、D、取代或未取代的C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C10~C30的取代或未取代的杂芳基;R
5和R
6的数量分别为0~4个,当R
5或R
6的数量为2个以上时,R
5相同或者不同,R
6相同或者不同;或者R
5和R
6独立地与相连接的苯环稠合形成C9~C12的芳基或杂芳基,所形成的芳基或杂芳基任选地被0~5个独立地选自取代或未取代的C1~C12烷基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基的取代基所取代;Y为C(R
7)
2、NR
8、O、S;n等于0或1,当n为0时,其表示与Y相连的两个碳原子直接相连;R
7和R
8独立地选自氢、C1~C5的烷基、苯基、卤素、氰基、硝基、羟基,两个R
7相同或者不同。
通过将上述通式(I)或(II)中的R
1设为以上通式(III)表示的结构,可以在分子中引入可作为电子给体的二苯并含氮杂环基团,以平衡载流子传输,从而提高使用上述化合物作为主体材料的有机电致发光器件的性能,使其具有高亮度、高效率、低驱动电压。
在上述化合物中,通式(III)中,n优选为0。通过将n设为0,可以将具有缺电子特性的通式(I)和(II)代表化合物与可作为电子给体的咔唑衍生物基团相连接,形成受体-给体型分子,提高分子的能隙及三线态能级,可以获得性能优良的双极性磷光主体材料,使分子上的载流子传输更加平衡,从而提高使用了该化合物的有机电致发光器件的亮度和效率。此外,使用了双极性材料的有机功能层可以使器件结构变得简单。
在上述化合物中,通式(III)中,L
3优选为单键或亚苯基。通过将L
3优选设为单键或亚苯基,可以使具有缺电子特性的通式(I)和(II)代表化合物与可作为电子给体的咔唑衍生物基团直接相连或隔着苯环相连,进一步提高其作为双极性主体材料的功能。
在上述化合物中,通式(III)中,优选R
5和R
6独立地选自氢、取代或未取代的C1~C4烷基、苯基、萘基、呋喃基、噻吩基、吡咯基、吡啶基、联苯基、三联苯基、萘基、蒽基、菲基、茚基、芴基及其衍生物、荧蒽基、三亚苯基、芘基、苝基、
基、并四苯基、三芳胺基、9,9-二甲基芴基、二苯乙烯基苯基、苯并芴基、茚并芴基或茚基、或者如式(V)所示二苯并杂芳基;或者R
5和R
6 独立地与与之相连的苯环稠合形成萘基、蒽基、菲基、茚基、芴基、苯并呋喃基、苯并噻吩基、苯并吡啶基、苯并吡咯基,或者如式(V)所示二苯并杂芳基:
其中,连接位点位于式(V)中的N上或者苯环上,当连接点位于(V)中的苯环上时,N与H、苯基、C1~C4的烷基相连;X’为C(R
9)
2、NR
10、O、S;m等于0或1,当m为0时,其表示与X’相连的两个碳原子直接相连;R
a、R
b、R
9和R
10独立地选自氢、C1~C5的烷基、C1~C5烷氧基、卤素、氰基、硝基、羟基、苯基,两个R
9相同或者不同;X’与Y相同或者不同。
在上述化合物中,上述通式(I)或(II)中,R
2~R
4分别独立地选自以下基团:
在上述化合物中,通式(I)或(II)中,优选R
1为以下基团中的一种:
R
1为以上基团中的一种的上述化合物作为掺杂型发光器件的双极性主体材料时,可以适当平衡载流子的传输,从而使激子均匀的分布,避免载流子在界面处的复合,减小高激子浓度下三线 态-三线态的猝灭。使用了R
1为以上基团中的一种的化合物的有机电致发光器件具有高亮度、高效率、低驱动电压。
在上述化合物中,通式(I)或(II)中,更优选R
1为以下基团中的一种:
R
1为以上基团中的一种时,可以进一步提高上述化合物作为掺杂型发光器件的双极性主体材料时的性能,进一步平衡载流子的传输从而减小高激子浓度下三线态-三线态的猝灭。使用了R
1为以上基团中的一种的化合物的有机电致发光器件能够具有更高的亮度、效率和更低的驱动电压。
在上述化合物中,通式(I)和(II)优选在X为CR
4时,R
2为氢,通式(I)和(II)更优选选自以下结构中的一种:
通过将通式(I)和(II)设为以上结构中的一种,可以得到结构更加优化母核,从而大大提高化合物的玻璃化转变温度Tg,提高使用了该化合物的有机电致发光材料的热及化学稳定性,从而提高了有机电致发光材料的寿命。
在上述化合物中,进一步优选R
1~R
4选自以下表1中的一种组合。这里对表1中第2列的R
2(R
4)进行说明,由于通式(I)和(II)选自以上结构中的一种,在X为N时,R
4不存在,在X为CR
4时,R
2为氢,因此R
2和R
4中必然有一个已经确定,为了使表格更简洁,在表1中将R
2和R
4放在同一列中,用R
2(R
4)表示另一个。
表1
通过将上述化合物中的R
1~R
4设为上表中的一种组合,可以大大提高包含上述化合物的有机电致发光器件的性能,使其具有高亮度、高效率、低驱动电压、较长的使用寿命。
本发明第一优选实施方案的稠杂环衍生物具有如下的优点中的一种、两种或者全部:
1.本实施方案提供的稠杂环衍生物,将具有缺电子特性的通式(I)和(II)代表化合物与可作电子给体的咔唑衍生物基团相连接,形成受体-给体型分子,提高分子的能隙及三线态能级,从而获得性能优良的双极性磷光主体材料。此外,作为母核的嘧啶并三氮唑基团或喹唑啉并三氮唑基团具有较大的共轭结构,使得化合物的玻璃化转变温度Tg大大提高,这样的有机电致发光材料具有较高的热及化学稳定性。
2.本实施方案的化合物作为掺杂型发光器件的双极性主体材料时,可以适当平衡载流子的传输,从而使激子均匀的分布,避免载流子在界面处的复合,减小高激子浓度下三线态-三线态的猝灭。而且,基于双极性材料的有机功能层可以使器件结构变得简单。
3.本实施方案制备的通式(I)和(II)代表化合物用作红色磷光发光层的主体材料时,也可以大大提高有机电致发光器件的性能,使其具有高亮度、高效率、低驱动电压、较长的使用寿命。
本发明的化合物的第二优选实施方案涉及一种化合物,其可用作主体材料,由以下通式(II)表示:
其中,Cy为苯环,X为N;L
1和L
2分别独立地选自单键、-O-、-S-、-NR
a-、C1~C5的亚烷基、(C1~C3亚烷基)-O-(C1~C3亚烷基)、C6~C30的亚芳基、C3~C30的亚杂芳基;R
1由以下通式(IV)表示,R
2、R
3分别独立地选自氢、氘、C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基;R
3的数量为0~4个,当R
3的数量为2个以上时,R
3相同或者不同;
其中,R
5和R
6独立地选自H、D、C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、硅烷基、氨基、C6~C30的取代或未取代的芳基氨基、C3~C30的取代或未取代的杂芳基氨基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基;R
5和R
6的数量分别为0~4个,当R
5或R
6的数量为2个以上时,R
5相同或者不同,R
6相同或者不同;或者R
5和R
6独立地与相连接的苯环稠合形成C9~C30的芳基或杂芳基,所形成的芳基或杂芳基任选地被0~5个独立地选自C1~C12烷基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基的取代基所取代;Y为C(R
7)
2、NR
8、O、S;n为0或1;当n为0时,其表示与Y相连的两个碳原子直接相连,R
7和R
8独立地选自氢、C1~C5的烷基、苯基、卤素、氰基、硝基、羟基;两个R
7相同或者不同。
上述化合物中,n优选为0。
上述化合物中,优选L
2为键,L
1为键、苯或萘。
上述化合物中,优选R
5和R
6独立的选自氢、取代或未取代的C1~C4烷基、苯基、萘基、呋喃基、噻吩基、吡咯基、吡啶基、联苯基、三联苯基、萘基、蒽基、菲基、茚基、芴基及其衍生物、荧蒽基、三亚苯基、芘基、苝基、
基、并四苯基、三芳胺基、9,9-二甲基芴基、二苯乙烯基苯基、苯并芴基、茚并芴基或茚基、或者如式(V)所示二苯并杂芳基;或者R
1和R
2独立的与与之 相连的苯环稠合形成萘基、蒽基、菲基、茚基、芴基、苯并呋喃基、苯并噻吩基、苯并吡啶基、苯并吡咯基,或者如式(V)所示二苯并杂芳基;
其中,连接位点位于式(V)中的N上或者苯环上,当连接点位于(V)中的苯环上时,N与H、苯基、C
1~C
4的烷基相连;X’为C(R
9)
2、NR
10、O、S;m为0或1;当m为0时,其表示与X’相连的两个碳原子直接相连,R
a、R
b、R
9和R
10独立的选自氢、C1~C5的烷基、C1~C5烷氧基、卤素、氰基、硝基、羟基、苯基;两个R
9相同或者不同;X’与Y相同或者不同。
上述化合物中,优选R
2选自H、D、取代或未取代的C1~C4烷基、苯基、被呋喃基、噻吩基、吡咯基和/或吡啶基取代的苯基、联苯基,三联苯基,萘基,蒽基,菲基,茚基,芴基及其衍生物,荧蒽基,三亚苯基,芘基,苝基,
基、并四苯基、呋喃基、苯基呋喃基、噻吩基、苯基噻吩基、吡咯基、苯基吡咯基、吡啶基、苯基吡啶基、吡嗪基、芴基、茚并芴基、喹啉、三嗪基、苯并呋喃基、苯并噻吩基、苯并三嗪、苯并吡嗪、异苯并呋喃基、吲哚基、苯并喹啉、二苯并呋喃基、二苯并噻吩基、二苯并吡咯基、三芳胺基、9,9-二甲基芴基、二苯乙烯基苯基、苯并芴基、茚并芴基或茚基、咔唑基、咔唑基及其衍生物、苯基取代的二唑、啡啉基、啡啉并噻唑基和苯并间二氧杂环戊烯基中的至少一种。
上述化合物中,当R
5和/或R
6与与之相连的苯环稠合时,与L
1相连的基团选自下式中的一种,其中*表示与L
1的连接位点:
上述化合物中,-L
2-R
2优选选自下式中的一种:
作为C1~C12的烷基,更优选为C1~C4的烷基,优选为甲基、乙基、异丙基、环己基;作为C1~C12的烷氧基,更优选为C1~C4的烷氧基,作为具体例可举出甲氧基、乙氧基、丙氧基、 异丙氧基等。
本实施方案提出的含有取代或非取代芳胺基的喹唑啉并三氮唑衍生物,是一种双极性磷光主体材料。理论上,双极性材料是理想的主体材料,因为基于双极性材料的有机功能层不但使器件结构变得简单,而且可以适当平衡载流子的传输,从而使激子均匀的分布,避免载流子在界面处的复合,减小高激子浓度下三线态-三线态的猝灭。在分子设计中,将电子缺乏的受体基团和电子丰富的给体基团连接起来,形成受体-给体型分子,这样将提高分子的能隙及三线态能级,从而可获得较高三线态、较宽能隙的优良双极性磷光主体材料。
本实施方案基于上述思想,将具有缺电子特性的喹唑啉并三氮唑基团与可作电子给体的咔唑衍生物基团相连接,这些化合物具有较大的空间结构,可以避免掺杂客体在能量传输中的堆垛淬熄,同时较大的空间结构使得材料的玻璃化转变温度Tg大大提高,这些材料同样具有很高的热及化学稳定性。在有机电致发光器件中,可作为掺杂型发光器件的双极性主体材料。
为了更清楚说明本实施方案的内容,下面具体叙述本实施方案涉及到的化合物的优选结构:
本实施方案提供的稠杂环衍生物具有高的玻璃化转变温度,高的熔点,同时具有高的载流子传输及发光效率。将该类衍生物应用于有机发光功能层作为发光层的主体材料,可以得到驱动电压低、发光效率高的有机电致发光器件。具体而言,本发明的稠杂环衍生物具有如下的优点中的一种、两种或者全部:
1、本发明提供的稠杂环衍生物,将具有缺电子特性的喹唑啉并三氮唑基团与可作电子给体的咔唑衍生物基团相连接,形成受体-给体型分子,提高分子的能隙及三线态能级,从而获得性能优 良的双极性磷光主体材料。此外,作为母核的喹唑啉并三氮唑基团具有较大的共轭结构,使得化合物的玻璃化转变温度Tg大大提高,这样的有机电致发光材料具有较高的热及化学稳定性。
2、本发明的化合物作为掺杂型发光器件的双极性主体材料时,可以适当平衡载流子的传输,从而使激子均匀的分布,避免载流子在界面处的复合,减小高激子浓度下三线态-三线态的猝灭。而且,基于双极性材料的有机功能层可以使器件结构变得简单。
3、本发明制备的式(1)所示化合物用作红色磷光发光层的主体材料时,也可以大大提高有机电致发光器件的性能,使其具有高亮度、高效率、低驱动电压、较长的使用寿命。本发明的化合物也可以与现有公知的发光层主体材料组合使用。
本发明的化合物的第三优选实施方案涉及一种化合物,其可用作电子传输材料,由以下通式(I)或(II)表示:
其中,X选自CR
4或N;R
1~R
4分别独立地选自氢、C1~C10的烷基、取代或未取代的C5~C60的芳基或杂芳基,所述芳基或杂芳基的取代基选自氘、氟、甲基、甲氧基、氰基、苯基、联苯基、萘基、菲基、取代或未取代的蒽基,所述蒽基的取代基选自苯基、联苯基、三联苯基、萘基、菲基;R
3的数量为1个;L
1和L
2为单键;通式(II)中的虚线和Cy表示与嘧啶环稠合的五元或六元的芳环或芳杂环。
为了提高材料的电子注入和传输性能,需要选择具有较强电子亲和能力的基团,常用的电子传输材料的基团包括吡啶、喹啉、邻菲罗啉、三嗪等基团。本实施方案的上述化合物采用了一类新颖的具有很强电子亲和能力的基团,高斯计算得出本发明化合物的LUMO约为-1.651eV,显著地低于常用的拉电子基团例如吡啶(-0.61eV)、喹啉(-1.38eV)、邻菲罗啉(-1.41eV)的LUMO能级,表明通式(I)和(II)类化合物具有高的电子亲和性,是一种优异的拉电子基团,具有此类取代基的化合物具有良好的电子注入性能。虽然本实施方案中的化合物具有上述良好性能的机理尚无定论,但据推测这是由于通式(I)和(II)类化合物具有非常好的共平面的共轭结构,使得具有此类取代基团的化合物分子在固态下能够充分发生基团间的π-π相互作用,有利于电子在材料分子间的传 递,从而使得含有这类化合物的材料具有非常高的电子迁移率。这类材料应用在OLED器件中有利于降低器件的工作电压,提高器件的发光效率。
在上述化合物中,通式(I)和(II)优选在X为CR
4时,R
2为氢,通式(I)和(II)更优选选自以下结构中的一种:
在上述化合物中,优选R
1~R
4中的至少一者包含蒽环结构,更优选R
1~R
4中的至少一者为以下通式(VI)表示的结构:
-L-B (VI)
其中,B为取代或未取代的蒽基,所述蒽基的取代基选自苯基、联苯基、三联苯基、萘基、菲基。L为单键、碳原子数为5~10的单环亚芳基或单环亚杂芳基,优选为单键、碳原子数为5~6的单环亚芳基或单环亚杂芳基,更优选为单键、亚苯基或亚吡啶基。
通过将R
1~R
4中至少一者设为上述结构,可以更好地利用蒽环的共轭结构和强电子亲和能力,提高上述化合物的电子传输性能。
另外,R
1~R
4中不为通式(VI)表示的结构的基团分别独立地选自以下基团:
在上述化合物中,通式(VI)表示的结构选自以下基团中的一种:
通式(VI)表示的结构更优选选自以下基团中的一种:
通过将通式(VI)表示的结构设为以上基团中的一种,可以提高电子在材料分子间的传递效率,使得上述化合物具有更高的电子迁移率。
在上述化合物中,进一步优选R
1~R
4选自以下表2中的一种组合。这里对表2中第2列的R
2(R
4)进行说明,由于通式(I)和(II)选自以上结构中的一种,在X为N时,R
4不存在,在X为CR
4时,R
2为氢,因此R
2和R
4中必然有一个已经确定,为了使表格更简洁,在表2中将R
2和R
4放在同一列中,用R
2(R
4)表示另一个。
表2
通过将R
1~R
4设为上表中的一种组合,可以更加充分地利用蒽环的共轭结构,进一步降低上述化合物的LUMO,提高上述化合物的电子亲和性,使上述化合物具有良好的电子注入性能。
本实施方案中的化合物,一方面由于母体结构所特有的高电子亲和势,因而与阴极材料的功函数更加接近,使得材料能够很容易的从阴极得到电子,具有强电子注入性;另一方面本材料具有很高的电子迁移率。综合以上两点,本实施方案的材料在单独使用的情况下,就能够实现业界常用的ET搭配LiQ所能实现的技术效果,从而避免使用对水和环境敏感的LiQ来搭配常规的ET材料,这样一方面在屏体量产线上,减少了材料的使用种类,有利于降低材料成本,另一方面可以减少量产设备的蒸发源数目,从而降低设备的设计制造成本和工艺复杂性,具有非常大的意义。
本发明的化合物的第四优选实施方案涉及一种化合物,其可用作电子传输材料,由以下通式(II)表示:
其中,Cy为苯环,X为N;L
1和L
2分别独立地选自单键、-O-、-S-、-NR
a-、C1~C5的亚烷基、(C1~C3亚烷基)-O-(C1~C3亚烷基)、C6~C30的亚芳基、C3~C30的亚杂芳基;R
1、R
2、R
3分别独立地选自H、取代或未取代的C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基,R
3的数量为1~4个,当R
3的数量为2个以上时,R
3相同或者不同,R
1和R
2中至少一个为取代或未取代的稠合芳基,所述稠合芳基中含有2个以上的苯环形成的稠合环,或者R
1、R
2和R
3同时为苯基。
在上述化合物中,优选R
1和R
2中至少一个为取代或未取代的稠合芳基,所述稠合芳基中含有2个以上的苯环形成的稠合环;并且所述的稠合芳基与其上的取代基或者是与连接于其的L
1或L
2形成共轭π键,所述的共轭π键中包括至少四个苯环,或者所述的稠合芳基自身所形成的共轭π键中包括至少三个苯环。
在上述化合物中,优选所述的R
1和R
2中的至少一个选自取代或未取代的萘基、蒽基、荧蒽基、芴基、菲基、芘基、苯并蒽基、苯并芘基;所述取代基为1~4个独立的选自H、取代或未取代的C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、硅烷基、C6~C18的取代或未取代的芳基、C3~C11的取代或未取代的杂芳基,所述取代基相同或者不同。
在上述化合物中,优选所述R
1和R
2中的至少一个为萘基或式(VII)所示的基团,其中*表示连接位点,式(VII)任选的被1~4个独立的选自H、取代或未取代的C1~C12烷基、C1~C12烷氧基、苯基、卤素、氰基、硝基、羟基的取代基所取代,所述取代基相同或者不同;其中Ar
3选自选自H、取代或未取代的C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、C6~C12的取代或未取代的芳基、C3~C11的取代或未取代的杂芳基;当式(VII)中存在两个Ar
3时,两个Ar
3相同或者不同;
在上述化合物中,优选L
1和L
2独立的为单键、苯基、呋喃基、噻吩基、吡咯基、吡啶基、 联苯基、三联苯基、或萘基。
在上述化合物中,优选所述Ar
3独立的选自氢、苯基、萘基、呋喃基、噻吩基、吡咯基、吡啶基、联苯基、三联苯基、萘基、蒽基、菲基、茚基、芴基及其衍生物、荧蒽基、三亚苯基、芘基、苝基、
基、并四苯基、三芳胺基、9,9-二甲基芴基、二苯乙烯基苯基、苯并芴基、茚并芴基或茚基。
在上述化合物中,当R
1和R
2中的其中一个为萘基或式(VII)所示的基团时,优选另外一个为氢、苯基、萘基、呋喃基、噻吩基、吡咯基、吡啶基、联苯基、三联苯基、萘基、蒽基、菲基、茚基、芴基及其衍生物、荧蒽基、三亚苯基、芘基、苝基、
基、并四苯基、三芳胺基、9,9-二甲基芴基、二苯乙烯基苯基、苯并芴基、茚并芴基或茚基。
作为本实施方案涉及到的化合物的优选结构可以列举如下,但不限于这些化合物。
为了提高材料的电子注入和传输性能,需要选择具有较强电子亲和能力的基团,常用的电子传输材料的基团包括吡啶、喹啉、邻菲罗啉、三嗪等基团,本实施方案中的化合物采用了一类新颖的具有很强电子亲和能力的基团:喹唑啉并三氮唑,高斯计算得出喹唑啉并三氮唑母体化合物的LUMO约为-1.651eV,显著地低于常用的拉电子基团例如吡啶(-0.61eV)、喹啉(-1.38eV)、邻菲罗啉(-1.41eV)的LUMO能级,表明喹唑啉并三氮唑基团具有高的电子亲和性,是一种优异的拉电子基团,具有此类取代基的化合物具有良好的电子注入性能。另外由于喹唑啉并三氮唑 具有非常好的共平面的共轭结构,使得具有此类取代基团的化合物分子在固态下能够充分发生基团间的π-π相互作用,从而有利于电子在材料分子间的传递,使得这类材料具有非常高的电子迁移率。这类材料应用在OLED器件中有利于降低器件的工作电压,提高器件的发光效率。
本实施方案中的化合物,一方面由于母体结构所特有的高电子亲和势,因而与阴极材料的功函数更加接近,使得材料能够很容易的从阴极得到电子,具有强电子注入性;另一方面本材料具有很高的电子迁移率。综合以上两点,本发明材料在单独使用的情况下,就能够实现业界常用的ET搭配QLi所能实现的技术效果,从而避免使用对水和环境敏感的QLi来搭配常规的ET材料,这样一方面在屏体量产线上,减少了材料的使用种类,有利于降低材料成本,另一方面可以减少量产设备的蒸发源数目,从而降低设备的设计制造成本和工艺复杂性,具有非常大的意义。
此外,发明人还发现,当喹唑啉并三氮唑类化合物被蒽基取代的时候,具有非常合适的HOMO、LUMO能级,所得的化合物适合成为电子和空穴传输通道,而且具有较高的电荷传输性能,这可能与HOMO、LUMO均分布在蒽基官能团上有关。蒽基官能团可以赋予化合物可逆的电化学氧化还原特性,这使得含有蒽基官能团的本发明化合物表现出优异的电子传输性能,因此作为器件的电子传输材料是优选的。
本发明还提供了上述化合物在有机电致发光器件中的应用。其中,上述化合物可以用作但不限于电子传输材料或发光层主体材料。
本发明还提供了一种有机电致发光器件,包括第一电极、第二电极和位于所述第一电极和第二电极之间的一层或多层有机层,其特征在于,所述有机层中包括至少一种上述化合物。作为第一电极和第二电极之间的有机层,通常包含电子注入层、电子传输层、发光层、空穴传输层、空穴注入层等有机层。
上述有机电致发光器件中,优选上述有机层包括空穴传输层、有机发光层以及电子传输层,所述有机发光层包括主体材料和掺杂染料,所述有机发光层的主体材料选自上述化合物。更优选地,所述掺杂材料为红色磷光染料。
上述的有机电致发光器件中,优选上述有机层包含电子注入层,所述电子注入层包含上述化合物;也优选上述有机层包含电子传输层,上述电子传输层包含上述的化合物。
本实施方案的化合物可以应用于有机电子器件中,有机电子器件如有机电致发光器件、照明元件、有机薄膜晶体管、有机场效应晶体管、有机薄膜太阳能电池、信息标签、电子人工皮肤片材、片材型扫描器等大面积传感器、电子纸及有机EL面板等。而且,基于双极性材料的有机功能层可以使器件结构变得简单。
本实施方案的有机电致发光器件基片可以使用传统有机发光器件中的基板,例如:玻璃或塑料,优选使用玻璃基板。
阳极材料可以采用透明的高导电性材料,例如铟锡氧(ITO)、铟锌氧(IZO)、二氧化锡(SnO2)、氧化锌(ZnO)等。本发明器件中优选使用ITO作阳极材料。
在本发明的器件中,空穴传输层厚度一般在5nm-5μm,空穴传输层可以采用N,N’-二(3-甲苯基)-N,N’-二苯基-[1,1-联苯基]-4,4’-二胺(TPD)或N,N’-二苯基-N,N’-二(1-萘基)-(1,1’-联苯基)-4,4’-二胺(NPB)等三芳胺类材料。器件结构可以为单发光层也可以是多发光层结构;每层发光层可以为单发光体发光材料结构也可以是掺杂结构;发光掺杂剂可以选用磷光材料;发光颜色不限,可以为如红、黄、蓝、绿等。
阴极可以采用金属及其混合物结构,如Mg∶Ag、Ca∶Ag等,也可以是电子注入层/金属层结构,如LiF/Al、Li
2O/Al等常见阴极结构。其中电子注入层可以为碱金属、碱土金属、过渡金属的单质、化合物或混合物,也可以是多层材料构成的复合阴极结构。
一般而言,有机电致发光器件包括介于阴极和阳极之间的多层有机功能层,其包括空穴传输层、发光层、电子传输层和电子注入层等。除以下一般说明以及实施例中所列举的内容以外,本领域技术人员已知的涉及有机电致发光器件的其它技术内容,例如制作方法及一般成分等,也适用于本发明中。
下面,参照以下实施例描述了本发明的代表化合物的制备方法。由于本发明化合物具有相同的骨架,本领域人员基于这些制备方法,可以通过已知的官能团转换方法、容易的合成其他本发明的化合物。以下,还提供包含所述化合物的发光器件的制备方法和发光性质测定。除特别说明外,本发明中所用原料、中间体均为市售商品;本发明中质谱采用ZAB-HS型质谱仪测定(英国Micromass公司制造)。
本申请第一优选实施方案和第三优选实施方案涉及的中间体制备大致可以分为两类,一类是嘧啶(衍生物)并三氮唑类中间体M1,另一类为嘧啶(衍生物)并咪唑类中间体M2。其制备方法如下:
中间体M1的制备:
以2,4-二氯嘧啶(或者其衍生物)为起始原料,首先与水合肼反应,取代掉2,4-二氯嘧啶(或者其衍生物)活性相对较高的4位氯原子生成中间体A。中间体A进而与醛缩合反应脱去一分子水生成中间体B。中间体B再与醋酸碘苯氧化关环反应生成第一类中间体M1。
中间体M2的制备:
以2,4-二氯嘧啶(或者其衍生物)为起始原料,首先与氨水反应,取代掉2,4-二氯嘧啶(或者其衍生物)活性高的4位氯原子生成中间体C。中间体C进而与α-溴代(杂)芳基或烷基乙基酮反应生成第二类中间体M2。
本申请第一优选实施方案的具体化合物的合成实施例如下:
实施例A1:化合物1I-12的制备
化合物1-1的制备
在烧瓶中将2,4-二氯嘧啶(500g,3.38mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(634g,10.14mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物1-1(389g,80%)。
化合物1-2的制备
将化合物1-1(144g,1mol)加入含有1.5L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(138g,1.3mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物1-2(151g,65%)。
化合物1-3的制备
将化合物1-2(151g,0.65mol)加入含有3L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(251g,0.78mol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。抽滤所得固体,正己烷淋洗,干燥得淡棕黄色固体化合物1-3(109g,73%)。
化合物1-4的制备
将N-苯基咔唑-3-硼酸(500g,1.742mol),3-溴咔唑(412g,1.584mol),碳酸钾(656g,4.752mol)溶于含甲苯∶乙醇∶水(3L、1L、1L)烧瓶中,室温搅拌下置换氮气后加入四三苯基膦钯(18.3g,0.016mol)。加毕,搅拌回流反应6小时,TLC监控反应终点。过滤析出的固体。液相分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=10∶1),得到化合物1-4(543g,收率81%)。
化合物1I-12的制备
将化合物1-3(5.44g,23.64mmo),化合物1-4(10g,23.64mmol),碳酸钾(10g,72.46mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到类白色固体化合物1I-12(12.1g,收率85%)。分子量计算值:602.22,实测值m/Z:602.2。
实施例A2:化合物1II-12的制备
化合物2-1的制备
将对氯苯硼酸(7.8g,50mmol),化合物1-3(11.5g,50mmol),碳酸钾(20.7g,150mmol)加入含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(578mg,0.5mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物2-1(10.7g,收率70%)。
化合物1II-12的制备
将化合物2-1(6.12g,20mmol),化合物1-4(8.46g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd
2(dba)
3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物1II-12(11.2g,收率81%)。分子量计算值:694.28,实测值m/Z:694.3。
实施例A3:化合物1II-63的制备
化合物3-1的制备
将二苯并呋喃-4-硼酸(116.6g,0.55mmol),化合物1-3(100.5g,0.5mol),碳酸钾(207g,1.5mol)加入含1,4-二氧六环/水(1.5L/0.5L)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(5.78g,5mmol)。加毕,搅拌下加热至回流反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物3-1(130g,收率90%)。
化合物3-2的制备
将化合物3-1(130g,0.45mol),PPh
3(295g,1.13mol)加入含邻二氯苯(1.5L)的烧瓶中,氮气氛,搅拌下加热至回流反应36小时,TLC监控反应终点。减压旋除溶剂,柱层析分离提纯得到化合物3-2(105g,收率91%)。
化合物1II-63的制备
将化合物2-1(6.12g,20mmol),化合物3-2(5.14g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd2(dba)3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物1II-63(9.2g,收率85%)。分子量计算值:543.21,实测值m/Z:543.2。
实施例A4:化合物1II-327的制备
化合物1II-327的制备
将化合物2-1(6.12g,20mmol),7H-二苯并咔唑(5.34g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd2(dba)3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物1II-327(9.1g,收率82%)。分子量计算值:553.23,实测值m/Z:553.2。
实施例A5:化合物2I-12的制备
化合物5-1的制备
将化合物2-氯-4-氨基嘧啶(129g,1mol),溴代苯乙酮(218g,1.1mol)加入含有1.3L DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物5-1(172g,75%)。
化合物2I-12的制备
将化合物5-1(4.58g,20mmol),化合物1-4(8.46g,20mmol),碳酸钾(8.3g,60mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到类白色固体化合物2I-12(10.6g,收率88%)。分子量计算值:601.23,实测值m/Z:601.2。
实施例A6:化合物2II-63的制备
化合物6-1的制备
将对氯苯硼酸(17.2g,0.11mmol),化合物5-1(22.9g,0.1mol),碳酸钾(41.4g,0.3mol)加入含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(1.2g,1mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物6-1(22.9g,收率75%)。
化合物2II-63的制备
将化合物6-1(6.1g,20mmol),化合物3-2(5.14g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd2(dba)3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物2II-63(9.4g,收率87%)。分子量计算值:542.21,实测值m/Z:542.2。
实施例A7:化合物2II-327的制备
化合物2II-327的制备
将化合物6-1(6.1g,20mmol),7H-二苯并咔唑(5.34g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd2(dba)3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物2II-327(8.8g,收率80%)。分子量计算值:552.23,实测值m/Z:552.2。
实施例A8:化合物3I-12的制备
化合物8-1的制备
将2,4-二氯喹唑啉(500g,2.5mol)溶于含10L乙醇烧瓶中,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤所得固体,用水和乙醇分别洗涤固体,晾干得到类白色固体化合物8-1(415g,86%)。
化合物8-2的制备
将化合物8-1(200g,1.03mol)加入含有2L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(120g,1.13mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物8-2(184g,63%)。
化合物8-3的制备
将化合物8-2(184g,652.4mmol)加入含有4L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(252g,782.9mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入4L正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥淡棕黄色固体化合物8-3(130g,71%)。
化合物3I-12的制备
将化合物8-3(7g,25mmol),化合物1-4(10g,23.64mmol),碳酸钾(10g,72.46mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物3I-12(11.5g,收率75%)。分子量计算值:652.24,实测值m/Z:652.2。
实施例A9:化合物3I-327的制备
化合物3I-327的制备
将化合物8-3(5.6g,20mmol),7H-二苯并咔唑(5.34g,20mmol),碳酸钾(8.3g,60mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到类白色固体化合物3I-327(9.1g,收率89%)。分子量计算值:511.18,实测值m/Z:511.2。
实施例A10:化合物3II-327的制备
化合物10-1的制备
将对氯苯硼酸(31.2g,0.2mol),化合物8-3(56g,0.2mmol),碳酸钾(82.8g,0.6mol)加入含1,4-二氧六环/水(900mL/300mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)4(2.31g,2mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物10-1(50.6g,收率71%)。
化合物3II-327的制备
将化合物10-1(7.1g,20mmol),7H-二苯并咔唑(5.34g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd2(dba)3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物3II-327(9.1g,收率89%)。分子量计算值:511.18,实测值m/Z:511.2。
实施例A11:化合物4I-12的制备
化合物11-1的制备
将化合物2-氯-4-氨基喹唑啉(179g,1mol),溴代苯乙酮(218g,1.1mol)加入含有1.3L DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物11-1(209g,75%)。
化合物4I-12的制备
将化合物11-1(5.58g,20mmol),化合物1-4(8.46g,20mmol),碳酸钾(8.3g,60mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到类白色固体化合物4I-12(10.6g,收率88%)。分子量计算值:601.23,实测值m/Z:601.2。
实施例A12:化合物4II-327的制备
化合物12-1的制备
将对氯苯硼酸(31.2g,0.2mol),化合物11-1(55.8g,0.2mmol),碳酸钾(82.8g,0.6mol)加入含1,4-二氧六环/水(900mL/300mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.31g,2mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物12-1(49g,收率69%)。
化合物4II-327的制备
将化合物12-1(7.1g,20mmol),7H-二苯并咔唑(5.34g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd2(dba)3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物4II-327(9.5g,收率79%)。分子量计算值:602.25,实测值m/Z:602.3。
实施例A13:化合物4I-63的制备
化合物4I-63的制备
将化合物11-2(5.6g,20mmol),化合物3-2(5.5g,20mmol),碳酸钾(8.3g,60mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到类白色固体化合物4I-63(8.8g,收率88%)。分子量计算值:500.16,实测值m/Z:500.2。
实施例A14:化合物5BII-327的制备
化合物14-1的制备
在烧瓶中将2,4-二氯吡啶并[3,4-d]嘧啶(497.5g,2.5mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物14-1(370.5g,76%)。
化合物14-2的制备
将化合物14-1(195g,1mol)加入含有2L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(138g,1.3mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物14-2(184g,65%)。
化合物14-3的制备
将化合物14-2(184g,650mmol)加入含有4L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(251g,780mmol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。抽滤析出的固体,正己烷淋洗,干燥得淡棕黄色固体化合物14-3(128g,70%)。
化合物5BII-327的制备
将化合物14-3(7.14g,20mmol),7H-二苯并咔唑(5.34g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd2(dba)3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物5BII-327(9.1g,收率75%)。分子量计算值:604.24,实测值m/Z:604.2。
实施例A15:化合物6BI-12的制备
化合物15-1的制备
将2,4-二氯吡啶并[3,4-d]嘧啶(49.8g,250mmol),28%氨水(94g,750mmol加入含500mL乙醇的烧瓶中,室温搅拌下搅拌反应48小时。TLC监控反应终点。过滤析出的固体,乙醇淋洗,干燥得到化合物15-1(27g,收率60%)。
化合物15-2的制备
将化合物15-1(27g,0.15mol),溴代苯乙酮(32.7g,0.165mol)加入含有400mL DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物15-2(31.5g,75%)。
化合物6BI-12的制备
将化合物15-2(5.6g,20mmol),化合物1-4(8.46g,20mmol),碳酸钾(8.3g,60mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到类白色固体化合物6BI-12(11.6g,收率89%)。分子量计算值:652.24,实测值m/Z:652.2。
实施例A16:化合物6BI-63的制备
将化合物15-2(5.6g,20mmol),化合物3-2(5.5g,20mmol),碳酸钾(8.3g,60mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到类白色固体化合物6BI-63(8.6g,收率86%)。分子量计算值:501.16,实测值m/Z:501.2。
实施例A17:化合物7AII-327的制备
化合物17-1的制备
在烧瓶中将2,4-二氯噻吩并[2,3-d]嘧啶(510g,2.5mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物17-1(375g,75%)。
化合物17-2的制备
将化合物17-1(375g,1.875mol)加入含有4L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(260g,2.45mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物17-2(351g,65%)。
化合物17-3的制备
将化合物17-2(351g,1.22mol)加入含有7L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(471g,1.46mol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。抽滤析出的固体,正己烷淋洗,干燥得淡棕黄色固体化合物17-3(251g,72%)。
化合物17-4的制备
将对氯苯硼酸(31.2g,0.2mol),化合物17-3(57.2g,0.2mmol),碳酸钾(82.8g,0.6mol)加入含1,4-二氧六环/水(900mL/300mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.31g,2mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物17-4(47g,收率65%)。
化合物7AII-327的制备
将化合物17-4(7.24g,20mmol),7H-二苯并咔唑(5.34g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd2(dba)3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物7AII-327(9g,收率76%)。分子量计算值:593.17,实测值m/Z:593.2。
实施例A18:化合物8AI-12的制备
化合物18-1的制备
将2,4-二氯噻吩并[2,3-d]嘧啶(51g,250mmol),28%氨水(94g,750mmol加入含500mL乙醇的烧瓶中,室温搅拌下搅拌反应48小时。TLC监控反应终点。过滤析出的固体,乙醇淋洗,干燥得到化合物18-1(29g,收率63%)。
化合物18-2的制备
将化合物18-1(27.8g,0.15mol),溴代苯乙酮(32.7g,0.165mol)加入含有400mL DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物18-2(32.5g,76%)。
化合物8AI-12的制备
将化合物18-2(5.7g,20mmol),化合物1-4(8.46g,20mmol),碳酸钾(8.3g,60mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水, 过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到类白色固体化合物8AI-12(11.2g,收率85%)。分子量计算值:657.20,实测值m/Z:657.2。
实施例A19:化合物9AII-327的制备
化合物19-1的制备
在烧瓶中将2,4-二氯噻吩并[3,2-d]嘧啶(510g,2.5mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物19-1(365g,73%)。
化合物19-2的制备
将化合物19-1(365g,1.825mol)加入含有4L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(251g,2.37mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物19-2(347g,66%)。
化合物19-3的制备
将化合物19-2(347g,1.2mol)加入含有7L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(465g,1.44mol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。抽滤析出的固体,正己烷淋洗,干燥得淡棕黄色固体化合物19-3(240g,70%)。
化合物19-4的制备
将对氯苯硼酸(15.6g,0.1mol),化合物19-3(28.6g,0.1mmol),碳酸钾(41.4g,0.3mol)加入含1,4-二氧六环/水(450mL/150mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(1.15g,1mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物19-4(24.6g,收率68%)。
化合物9AII-327的制备
将化合物19-4(7.24g,20mmol),7H-二苯并咔唑(5.34g,20mmol),叔丁醇钠(5.8g,60mmol)加入含有200mL二甲苯的烧瓶中,氮气氛搅拌下加入Pd2(dba)3(183mg,0.2mmol),三叔丁基膦(50%二甲苯溶液)(242mg,0.6mmol),加毕,加热回流反应15小时,TLC显示反应完全。减压旋干溶剂,二氯甲烷溶解,水洗,无水硫酸钠干燥,柱层析得到类白色固体化合物9AII-327(9.1g,收率75%)。分子量计算值:609.20,实测值m/Z:609.2。
实施例A20:化合物10AI-12的制备
化合物20-1的制备
将2,4-二氯噻吩并[3,2-d]嘧啶(51g,250mmol),28%氨水(94g,750mmol加入含500mL乙醇的烧瓶中,室温搅拌下搅拌反应48小时。TLC监控反应终点。过滤析出的固体,乙醇淋洗,干燥得到化合物20-1(29.6g,收率64%)。
化合物20-2的制备
将化合物20-1(29.6g,0.16mol),溴代苯乙酮(34.8g,0.176mol)加入含有400mL DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物20-2(32.8g,72%)。
化合物10AI-12的制备
将化合物20-2(5.7g,20mmol),化合物1-4(8.46g,20mmol),碳酸钾(8.3g,60mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到类白色固体化合物10AI-12(11.4g,收率87%)。分子量计算值:657.20,实测值m/Z:657.2。
本申请第二优选实施方案的具体化合物的合成实施例如下:
实施例C1:化合物C1的制备
化合物1-1的制备
将2,4-二氯喹唑啉(500g,2.5mol)溶于含10L乙醇烧瓶中,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤所得固体,用水和乙醇分别洗涤固体,晾干得到类白色固体化合物1-1(415g,86%)。
化合物1-2的制备(参考文献J.Heterocyclic chem.27,497,1990)
将化合物1-1(200g,1.03mol)加入含有2L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(120g,1.13mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物1-2(184g,63%)。
化合物1-3的制备
将化合物1-2(184g,652.4mmol)加入含有4L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(252g,782.9mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入4L正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥淡棕黄色固体化合物1-3(130g,71%)。
化合物1-4的制备
将N-苯基咔唑-3-硼酸(500g,1.742mol),3-溴咔唑(412g,1.584mol),碳酸钾(656g,4.752mol)溶于含甲苯∶乙醇∶水(3L、1L、1L)烧瓶中,室温搅拌下置换氮气后加入四三苯基膦钯(18.3g,0.016mol)。加毕,搅拌回流反应6小时,TLC监控反应终点。过滤析出的固体。液相分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=10∶1),得到化合物1-4(543g,收率81%)。
化合物C1的制备
将化合物1-3(7g,25mmol),化合物1-4(10g,23.64mmol),碳酸钾(10g,72.46mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入200mL 水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物C1(11.5g,收率75%)。分子量计算值:652.24,实测值m/Z:652.2。
实施例C2:化合物C2的制备
化合物2-1的制备
将化合物1-1(20g,103mmol)加入含有200mL乙醇的烧瓶中,室温搅拌下滴加苯对甲基甲醛(15g,125mmol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物2-1(19.8g,65%)。
化合物2-2的制备
将化合物2-1(19.8g,67mmol)加入含有200L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(25.8g,80.1mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入200mL正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥淡棕黄色固体化合物2-2(14.6g,74%)。
化合物C2的制备
将化合物2-2(7.35g,25mmol),化合物1-4(10g,23.64mmol),碳酸钾(10g,72.46mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物C2(11.2g,收率71%)。分子量计算值:666.25,实测值m/Z:666.2。
实施例C3:化合物C6的制备
化合物3-1的制备
将化合物1-1(20g,103mmol)加入含有200mL乙醇的烧瓶中,室温搅拌下滴3-甲醛基吡啶(13.3g,125mmol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物3-1(16.3g,56%)。
化合物3-2的制备
将化合物3-1(16.3g,57.6mmol)加入含有200L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(22.3g,69.1mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入200mL正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥得淡棕黄色固体化合物3-2(10g,70%)。
化合物C6的制备
将化合物2-2(7.03g,25mmol),化合物1-4(10g,23.64mmol),碳酸钾(10g,72.46mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。固体用二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷~二氯甲烷∶甲醇=10∶1)得到淡黄色固体化合物C6(10.6g,收率65%)。分子量计算值:653.23,实测值m/Z:653.2。
实施例C4:化合物C9的制备
化合物4-1的制备
将化合物1-1(20g,103mmol)加入含有200mL乙醇的烧瓶中,室温搅拌下加入二苯并呋喃-2-甲醛(24.5g,125mmol),加毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物4-1(25.6g,67%)。
化合物4-2的制备
将化合物4-1(25.6g,69mmol)加入含有200L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(26.7g,82.8mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入200mL正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥得棕黄色固体化合物4-2(17.8g,70%)。
化合物C9的制备
将化合物4-2(9.25g,25mmol),化合物1-4(10g,23.64mmol),碳酸钾(10g,72.46mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤得淡黄色固体。所得固体用二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物C9(12.8g,收率73%)。分子量计算值:742.25,实测值m/Z:742.2。
实施例C5:化合物C12的制备
化合物5-1的制备
将化合物1-1(20g,103mmol)加入含有200mL乙醇的烧瓶中,室温搅拌下加入对苯基苯甲醛(22.7g,125mmol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得淡黄色固体化合物5-1(24.3g,66%)。
化合物5-2的制备
将化合物5-1(24.3g,69mmol)加入含有200L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(26.7g,82.8mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入200mL正己烷搅拌5分钟后抽滤得到固体,正己烷淋洗,干燥得淡棕黄色固体化合物5-2(18.1g,74%)。
化合物C12的制备
将化合物5-2(8.9g,25mmol),化合物1-4(10g,23.64mmol),碳酸钾(10g,72.46mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤得淡黄色固体。所得固体用二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物C12(12g,收率70%)。分子量计算值:728.27,实测值m/Z:728.2。
实施例C6:化合物C13的制备
化合物6-1的制备
将对溴苯甲醛(18.4g,0.1mol),4-吡啶硼酸(12.3g,0.1mol),碳酸钾(41.4g,0.3mol)溶于含1,4-二氧六环∶水(0.3L/0.1L)的烧瓶中,室温搅拌下置换氮气后加入四三苯基膦钯(1.15g,1mmol)。加毕,搅拌回流反应6小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为石油醚∶乙酸乙酯=2∶1),得到化合物6-1(15g,收率82%)。
化合物6-2的制备
将化合物1-1(13.4g,69mmol)加入含有200mL乙醇的烧瓶中,室温搅拌下加入6-1(15g,82mmol),加毕继续搅拌反应30分钟,过滤得到固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物6-2(15.1g,61%)。
化合物2-2的制备
将化合物2-1(15.1g,42mmol)加入含有200L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(16.1g,50mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入200mL正己烷搅拌5分钟后抽滤得到固体,所得固体用正己烷淋洗,干燥棕黄色固体化合物6-3(10.5g,70%)。
化合物C13的制备
将化合物6-3(8.93g,25mmol),化合物1-4(10g,23.64mmol),碳酸钾(10g,72.46mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷~二氯甲烷∶甲醇=10∶1)得到类白色固体化合物C13(11.2g,收率65%)。分子量计算值:729.26,实测值m/Z:729.2。
实施例C7:化合物C23的制备
化合物7-1的制备
将2,4-二氯-7-溴喹唑啉(50g,0.181mol)溶于含1L乙醇烧瓶中,搅拌下在5℃滴加水合肼(34g,0.543mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤所得固体,用水和乙醇分别洗涤固体,晾干得到类白色固体化合物7-1(39.4g,80%)。
化合物7-2的制备
将化合物7-1(39,4g,0.145mol)加入含有0.4L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(18.4g,0.174mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得淡黄色固体化合物7-2(34g,65%)。
化合物7-3的制备
将化合物7-2(34g,94.3mmol)加入含有0.4L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(36.4g,113.2mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入0.4L正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥淡棕黄色固体化合物7-3(23.6g,70%)。
化合物7-4的制备
将化合物7-3(7.5g,21mmol),化合物1-4(8.5g,20mmol),碳酸钾(8.3g,60mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物7-4(11.1g,收率76%)。
化合物C23的制备
将苯硼酸(1.85g,15.2mmol),化合物7-4(11.1g,15.2mmol),碳酸钾(6.3g,45.6mmol)溶于含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入四三苯基膦钯 (176mg,0.152mmol)。加毕,搅拌回流反应8小时,TLC监控反应终点。过滤析出的固体。液相分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=5∶1),得到化合物C23(7.75g,收率70%)。分子量计算值:728.27,实测值m/Z:728.2。
实施例C8:化合物C25的制备
化合物8-1的制备
将化合物1-4(12.69g,30mmol),对溴碘苯(13.4g,45mmol),CuI(2.86g,15mmol),乙二胺(1.8g,30mmol),磷酸钾(19.1g,90mmol)加入含300mL甲苯的烧瓶中,氮气氛下加热回流反应20小时,TLC监控反应终点。加水搅拌分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=10∶1),得到化合物8-1(13.7g,收率79%)。
化合物8-2的制备
将化合物8-1(13.7g,23.7mmol),硼酸频哪醇酯(9.04g,35.6mmol),醋酸钾(7g,71.1mmol)溶于含300mL 1,4-二氧六环的烧瓶中,室温搅拌下置换氮气后加入Pd(dppf)
2Cl
2(196mg,0.24mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。加水分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=2∶1),得到化合物8-1(10.4g,收率70%)。
化合物C25的制备
将化合物8-2(10.4g,16.6mmol),化合物1-3(4.88g,17.4mmol),碳酸钾(6.9g,49.8mmol)溶于含1,4-二氧六环∶水(210mL∶70mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(196mg,0.17mmol)。加毕,搅拌回流反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=5∶1),得到化合物C25(9g,收率75%)。分子量计算值:728.27,实测值m/Z:728.2。
实施例C9:化合物C29的制备
化合物9-1的制备
将化合物1-1(20g,103mmol)加入含有200mL乙醇的烧瓶中,室温搅拌下加入3-苯基苯甲醛(20.6g,113mol),加毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物9-1(22.9g,62%)。
化合物9-2的制备
将化合物9-1(22.9g,64mmol)加入含有400mL乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(24.7g,76.8mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入400mL正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥淡棕黄色固体化合物9-2(16.2g,71%)。
化合物9-3的制备
将二苯并呋喃-2-硼酸(50g,0.236mol),3-溴咔唑(55.9g,0.215mol),碳酸钾(89g,0.645mol)溶于含甲苯∶乙醇∶水(300mL、100mL、100mL)的烧瓶中,室温搅拌下置换氮气后加入四三苯基膦钯(2.5g,2.15mmol)。加毕,搅拌回流反应8小时,TLC监控反应终点。过滤析出的固体。液相分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=10∶1),得到化合物9-3(59.8g,收率 80%)。
化合物C29的制备
将化合物9-2(10.7g,30.2mmol),化合物9-3(10g,28.7mmol),碳酸钾(11.9g,86.1mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入200mL水,过滤得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物C29(13.7g,收率73%)。分子量计算值:653.22,实测值m/Z:653.2。
实施例C10:化合物C32的制备
化合物10-1的制备
将2,8-二溴二苯并噻吩(20g,58.8mmol),苯硼酸(7.2g,58.8mmol),碳酸钾(24.3g,176mmol)溶于含甲苯∶乙醇∶水(300mL、100mL、100mL)的烧瓶中,室温搅拌下置换氮气后加入四三苯基膦钯(693mg,0.6mmol)。加毕,搅拌回流反应6小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=15∶1),得到化合物10-1(15.3g,收率77%)。
化合物10-2的制备
氮气氛下,将化合物10-1(15.3g,45.3mmol)加入含有200mL无水四氢呋喃的烧瓶中,-78℃下,滴加2.5M正丁基锂(20mL,49.8mmol),滴毕自然升至0℃反应30分钟,降温至-78℃滴加硼酸三乙丙酯(12.8g,68mmol),滴毕,自然升至室温反应2小时,滴加20mL 1M稀盐酸反应1小时。加入乙酸乙酯,分液,水相用乙酸乙酯萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。乙醇洗涤,得到化合物10-2(11.2g,收率81%)。
化合物10-3的制备
将3-溴咔唑(8.2g,33.5mmol),化合物10-2(11.2g,36.8mmol),碳酸钾(13.8g,100mmol)溶于含甲苯∶乙醇∶水(150mL、50mL、50mL)的烧瓶中,室温搅拌下置换氮气后加入四三苯基膦钯(393mg,0.34mmol)。加毕,搅拌回流反应6小时,TLC监控反应终点。过滤析出的固体。液相分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=12∶1),得到化合物10-3(12g,收率84%)。
化合物C32的制备
将化合物10-3(8g,18.8mmol),化合物9-2(7g,19.7mmol),碳酸钾(7.8g,56.4mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷~乙酸乙酯)得到类白色固体化合物C32(10g,收率71%)。分子量计算值:745.23,实测值m/Z:745.2。
实施例C11:化合物C33的制备
化合物11-1的制备
将2-溴硝基苯(10g,49.75mmol),二苯并呋喃-4-硼酸(11.1g,52.2mmol),碳酸钾(20.6g,149mmol)溶于含甲苯∶乙醇∶水(150mL、50mL、50mL)的烧瓶中,室温搅拌下置换氮气后加入四三苯基膦钯(578mg,0.5mmol)。加毕,搅拌回流反应6小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=10∶1),得到化合物11-1(12.8g,收率89%)。
化合物11-2的制备
将化合物11-1(12.8g,44.3mmol),三苯基膦(29g,110.7mmol)加入含有300mL邻二氯苯的烧瓶中,氮气氛搅拌下加热回流反应36小时,TLC显示反应完全。旋除溶剂,二氯甲烷溶解,柱层析(洗脱剂为石油醚∶二氯甲烷=5∶1~1∶1)得到类白色固体化合物11-2(9.45g,收率83%)。
化合物C33的制备
将化合物11-2(8g,31.1mmol),化合物5-2(11.6g,32.7mmol),碳酸钾(12.9g,93.3mmol)加入含有300mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入300mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷~乙酸乙酯)得到类白色固体化合物C33(14g,收率78%)。分子量计算值:577.19,实测值m/Z:577.2。
实施例C12:化合物C36的制备
化合物12-1的制备
将化合物1-1(20g,103mmol)加入含有200mL乙醇的烧瓶中,室温搅拌下加人2-萘甲醛(17.6g,113mmol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物12-1(22.2g,65%)。
化合物12-2的制备
将化合物12-1(22.2g,67mmol)加入含有400mL乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(25.9g,80.4mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入400mL正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥淡棕黄色固体化合物12-2(15.5g,70%)。
化合物C36的制备
将化合物11-2(10g,38.9mmol),化合物12-2(13.5g,40.9mmol),碳酸钾(16.1g,116.7mmol)加入含有300mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入300mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物C36(13g,收率61%)。分子量计算值:551.17,实测值m/Z:551.2。
实施例C13:化合物C41的制备
化合物13-2的制备
将化合物13-1(10g,36.8mmol),碘苯(12.1g,55.1mmol),CuI(3.2g,16.8mmol),乙二胺(2.2g,36.8mmol),磷酸钾(23.4g,110.4mmol)加入含200mL甲苯的烧瓶中,氮气氛下加热回流反应20小时,TLC监控反应终点。加水搅拌分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干 燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=12∶1),得到化合物13-2(10.9g,收率85%)。
化合物C41的制备
将化合物13-2(10.9g,31.3mmol),化合物1-3(9.2g,32.9mmol),碳酸钾(13g,93.9mmol)加入含有200mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入200mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物C41(14.5g,收率78%)。分子量计算值:592.24,实测值m/Z:592.2。
实施例C14:化合物C55的制备
化合物14-1的制备
将2-硝基苯硼酸(15g,89.8mmol),对溴苯甲醛(15.7g,85.5mmol),碳酸钾(35.4g,256.5mmol)溶于含甲苯∶乙醇∶水(300mL、100mL、100mL)的烧瓶中,室温搅拌下置换氮气后加入四三苯基膦钯(1.04g,0.9mmol)。加毕,搅拌回流反应6小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=9∶1),得到化合物14-1(16.7g,收率86%)。
化合物14-2的制备
将化合物14-1(16.7g,73.5mmol),三苯基膦(48.2g,184mmol)加入含有300mL邻二氯苯的烧瓶中,氮气氛搅拌下加热回流反应36小时,TLC显示反应完全。旋除溶剂,二氯甲烷溶解,柱层析(洗脱剂为石油醚∶二氯甲烷=20∶1~10∶1)得到类白色固体化合物14-2(11.75g,收率82%)。
化合物14-3的制备
将化合物14-2(11.75g,60.3mmol),碘苯(18.4g,90.4mmol),CuI(5.7g,30mmol),乙二胺 (3.6g,60.3mmol),磷酸钾(38.4g,181mmol)加入含300mL甲苯的烧瓶中,氮气氛下加热回流反应20小时,TLC监控反应终点。加水搅拌分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=12∶1),得到化合物14-3(13.1g,收率80%)。
化合物14-4的制备
将化合物1-1(7.8g,40.3mmol)加入含有150mL乙醇的烧瓶中,室温搅拌下加入14-3(13.1g,48.3mmol),加毕继续搅拌反应30分钟,过滤得到固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物14-4(12.4g,69%)。
化合物14-5的制备
将化合物14-4(12.4g,27.8mmol)加入含有250L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(10.7g,33.4mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入250mL正己烷搅拌5分钟后抽滤得到固体,所得固体用正己烷淋洗,干燥得棕黄色固体化合物14-5(8.9g,72%)。
化合物C55的制备
将化合物14-5(8.9g,20mmol),7H-二苯并咔唑(5.08g,19mmol),碳酸钾(7.9g,57mmol)加入含有150mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应15小时,TLC显示反应完全。加入150mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷~乙酸乙酯)得到类白色固体化合物C55(9.9g,收率77%)。分子量计算值:676.24,实测值m/Z:676.2。
实施例C15:化合物C61的制备
化合物C61的制备
将化合物7H-二苯并咔唑(10g,37.4mmol),化合物9-2(14g,39.3mmol),碳酸钾(15.5g,112.2mmol)加入含有300mL乙腈的烧瓶中,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。加入300mL水,过滤所得淡黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷-乙酸乙酯)得到类白色固体化合物C61(15g,收率68%)。分子量计算值:587.21,实测值m/Z:587.2。
本申请第三优选实施方案的具体化合物的合成实施例如下:
实施例B1:
化合物1-121的制备
化合物1-1的制备
在烧瓶中将2,4-二氯嘧啶(500g,3.38mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(634g,10.14mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物1-1(389g,80%)。
化合物1-2的制备
将化合物1-1(144g,1mol)加入含有1.5L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(138g,1.3mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物1-2(151g,65%)。
化合物1-3的制备
将化合物1-2(151g,0.65mol)加入含有3L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(251g,0.78mol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。抽滤所得固体,正己烷淋洗,干燥得淡棕黄色固体化合物1-3(109g,73%)。
化合物1-4的制备
将
2-溴-9,10-二(B-萘基)-蒽(508g,1mol),硼酸频哪醇酯(381g,1.5mol),醋酸钾(294g,3mol)加入含1,4-二氧六环(3L)烧瓶中,室温搅拌下置换氮气后加入Pd(dppf
2)Cl
2(7.32g,0.01mol)。加毕,搅拌回流反应24小时,TLC监控反应终点。过滤析出的固体。水洗,干燥得到化合物1-4(500.4g,收率90%)。
化合物1-121的制备
将化合物1-3(5.75g,25mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热至90℃反应12小时,TLC显示反应完全。过滤 析出的黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物1-121(7.8g,收率70%)。分子量计算值:624.23,实测值C/Z:624.2。
实施例B2:
化合物1-124的制备
化合物2-1的制备
将化合物5-溴-2,4-二氯嘧啶(45.2g,200mmol)加入含有500mL乙醇的烧瓶中,搅拌下在5℃滴加水合肼(37.5g,600mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物2-1(33.3g,75%)。
化合物2-2的制备
将化合物2-1(33.3g,0.15mol)加入含有350mL乙醇的烧瓶中,室温搅拌下滴加苯甲醛(20.7g,0.2mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物2-2(28g,60%)。
化合物2-3的制备
将化合物2-2(28g,0.09mol)加入含有300mL乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(34.8g,0.11mol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。抽滤所得固体,正己烷淋洗,干燥得淡棕黄色固体化合物2-3(19.7g,71%)。
化合物2-4的制备
将化合物2-3(7.7g,25mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热至90℃反应12小时,TLC显示反应完全。过滤 析出的黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物2-4(8.2g,收率65%)。
化合物1-124的制备
将化合物2-4(8.2g,11.7mmol),吡啶-3-硼酸(1.73g,14mmol),碳酸钾(4.84g,35.1mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(139mg,0.12mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物1-124(6.8g,收率83%)。分子量计算值:701.26,实测值C/Z:701.3。
实施例B3:
化合物1-321的制备
化合物3-1的制备
将对氯
苯硼酸(7.8g,50mmol),化合物1-3(11.5g,50mmol),碳酸钾(20.7g,150mmol)加入含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(578mg,0.5mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物3-1(10.7g,收率70%)。
化合物3-2的制备
将化合物3-1(10.7g,35mmol),硼酸频哪醇酯(13.3g,52.5mmol),磷酸钾(14.5g,105mmol)加入含1,4-二氧六环(300mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(320mg,0.35mmol),Sphos(431mg,1.05mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物3-2(15.1g,收率80%)。
化合物1-321的制备
将9-溴-10-萘基蒽(5.73g,15mmol),化合物3-2(5.97g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4 (173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物1-321(4.3g,收率85%)。分子量计算值:574.22,实测值C/Z:574.2。
实施例B4:
化合物2-121的制备
化合物4-1的制备
将化合物2-氯-4-氨基嘧啶(129g,1mol),溴代苯乙酮(218g,1.1mol)加入含有1.3L DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物4-1(172g,75%)。
化合物2-121的制备
将化合物4-1(4.1g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热至80℃反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物2-121(8.7g,收率78%)。分子量计算值:623.24,实测值C/Z:623.2。
实施例B5:
化合物2-114的制备
化合物5-1的制备
将5-溴-2,4-二氯嘧啶(56.5g,250mmol),28%氨水(94g,750mmol加入含500mL乙醇的烧瓶中,室温搅拌下搅拌反应48小时。TLC监控反应终点。过滤析出的固体,乙醇淋洗,干燥得到化合物5-1(34g,收率66%)。
化合物5-2的制备
将化合物5-1(34g,165mmol),溴代苯乙酮(36g,182mmol)加入含有600mL DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得棕黄色固体化合物5-2(35.5g,70%)。
化合物5-3的制备
将化合物5-2(5.5g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热至80℃反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物5-3(9g,收率71%)。
化合物2-114的制备
将化合物5-3(9g,12.8mmol),吡啶-3-硼酸(1.73g,14mmol),碳酸钾(5.3g,38.4mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(150mg,0.13mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所 得固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物2-114(7.8g,收率87%)。分子量计算值:700.26,实测值C/Z:700.3。
实施例B6:
化合物2-411的制备
化合物6-1的制备
将2-氯-4-氨基嘧啶(64.5g,0.5mol),溴丙酮(81.6g,0.6mmol)加入含有700mL DMF的烧瓶中,搅拌下加热至100℃反应15小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体,用乙醇淋洗,干燥后柱层析得到得棕黄色固体化合,6-1(58.7g,72%)。
化合物6-2的制备
将对氯
苯硼酸(34.3g,220mmol),化合物6-1(33.4g,200mmol),碳酸钾(82.8g,600mmol)加入含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.3g,0.2mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物6-2(35.9g,收率74%)。
化合物6-3的制备
将化合物6-2(24.3g,100mmol),硼酸频哪醇酯(38.1g,150mmol),磷酸钾(41.4g,300mmol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(1.15g,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物6-3(26.8g,收率80%)。
化合物2-411的制备
将
9-(4-联苯基)-10-溴蒽(6.12g,15mmol),化合物6-3(5.03g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物2-411(6.9g,收率86%)。分子量计算值:537.22,实测值C/Z:537.2。
实施例B7:
化合物3-121的制备
化合物7-1的制备
在烧瓶中将2,4-二氯喹唑啉(500g,2.5mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物7-1(415g,86%)。
化合物7-2的制备
将化合物7-1(200g,1.03mol)加入含有2L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(120g,1.13mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物7-2(184g,63%)。
化合物7-3的制备
将化合物7-2(184g,652.4mmol)加入含有4L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(252g,782.9mmol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。加入4L正己烷搅拌5分钟后抽滤析出的固体,正己烷淋洗,干燥得淡棕黄色固体化合物7-3(130g,71%)。
化合物3-121的制备
将化合物7-3(5g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤析出的黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物3-121(8.5g,收率70%)。分子量计算值:674.25,实测值C/Z:674.2。
实施例B8:
化合物3-321的制备
化合物8-1的制备
将对氯
苯硼酸(31.2g,0.2mol),化合物7-3(56g,0.2mmol),碳酸钾(82.8g,0.6mol)加入含1,4-二氧六环/水(900mL/300mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.31g,2mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物8-1(50.6g,收率71%)。
化合物8-2的制备
将化合物8-1(35.6g,0.1mol),硼酸频哪醇酯(38.1g,0.15mol),磷酸钾(41.4g,0.3mol)加入含1,4-二氧六环(1L)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(916mg,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物8-2(31.4g,收率70%)。
化合物3-321的制备
将9-溴-10-萘基蒽(5.73g,15mmol),化合物8-2(6.72g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物3-321(7.5g,收率88%)。分子量计算值624.23,实测值C/Z:624.2。
实施例B9:
化合物3-401的制备
化合物9-1的制备
将化合物
7-1(19.4g,0.1mol),原甲酸三甲酯(150ml,做溶剂)加入烧瓶中,搅拌下加热至回流反应3小时,TLC监控反应终点。减压旋除溶剂,乙醇煮洗,抽滤干燥得到化合物9-1(17.5g,收率86%)。
化合物9-2的制备
将对氯
苯硼酸(14.8g,94.6mmol),化合物9-1(17.5g,86mmol),碳酸钾(35.6g,258mmol)加入含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(1g,0.86mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物9-2(16.9g,收率70%)。
化合物9-3的制备
将化合物9-2(16.8g,60mmol),硼酸频哪醇酯(22.9g,90mmol),磷酸钾(38.2g,180mmol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(550mg,0.6mmol),Sphos(738mg,1.8mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物9-3(16.7g,收率75%)。
化合物3-401的制备
将
9-(4-联苯基)-10-溴蒽(6.12g,15mmol),化合物9-3(5.58g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4 (173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物3-401(7.1g,收率83%)。分子量计算值:574.22,实测值C/Z:574.2。
实施例B10:
化合物4-121的制备
化合物10-1的制备
将化合物2-氯-4-氨基喹唑啉(179g,1mol),溴代苯乙酮(218g,1.1mol)加入含有1.3L DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物10-1(209g,75%)。
化合物4-121的制备
将化合物10-1(5g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热至80℃反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物4-121(9.1g,收率75%)。分子量计算值:673.25,实测值C/Z:673.2。
实施例B11:
化合物4-321的制备
化合物11-1的制备
将对氯
苯硼酸(31.2g,0.2mol),化合物10-1(55.8g,0.2mmol),碳酸钾(82.8g,0.6mol)加入含1,4-二氧六环/水(900mL/300mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.31g,2mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物11-1(49g,收率69%)。
化合物11-2的制备
将化合物11-1(35.5g,0.1mol),硼酸频哪醇酯(38.1g,0.15mol),磷酸钾(41.4g,0.3mol)加入含1,4-二氧六环(1L)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(916mg,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物11-2(31.7g,收率71%)。
化合物4-321的制备
将9-溴-10-萘基蒽(5.73g,15mmol),化合物11-2(6.71g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物4-321(7.9g,收率85%)。分子量计算值623.24,实测值C/Z:623.2。
实施例B12:
化合物4-411的制备
化合物12-1的制备
将2-氯-4-氨基喹唑啉(89.5g,0.5mol),溴丙酮(81.6g,0.6mmol)加入含有700mL DMF的烧瓶中,搅拌下加热至100℃反应15小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体,用乙醇淋洗,干燥后柱层析得到得棕黄色固体化合,12-1(79.2g,73%)。
化合物12-2的制备
将对氯
苯硼酸(34.3g,220mmol),化合物12-1(43.4g,200mmol),碳酸钾(82.8g,600mmol)加入含1,4-二氧六环/水(600mL/200mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.3g,0.2mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。抽滤所得固体,柱层析分离提纯得到化合物12-2(43.9g,收率75%)。
化合物12-3的制备
将化合物12-2(29.3g,100mmol),硼酸频哪醇酯(38.1g,150mmol),磷酸钾(41.4g,300mmol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(1.15g,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物12-3(30.8g,收率80%)。
化合物4-411的制备
将
9-(4-联苯基)-10-溴蒽(6.12g,15mmol),化合物12-3(5.78g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物4-411(7.3g,收率83%)。分子量计算值:587.24,实测值C/Z:587.2。
实施例B13:
化合物5B-121的制备
化合物13-1的制备
在烧瓶中将
2,4-二氯吡啶并[3,4-d]嘧啶(497.5g,2.5mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物13-1(370.5g,76%)。
化合物13-2的制备
将化合物13-1(195g,1mol)加入含有2L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(138g,1.3mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物13-2(184g,65%)。
化合物13-3的制备
将化合物13-2(184g,650mmol)加入含有4L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(251g,780mmol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。抽滤析出的固体,正己烷淋洗,干燥得淡棕黄色固体化合物13-3(128g,70%)。
化合物5B-121的制备
将化合物13-3(5.06g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤析出的黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物5B-121(8.6g,收率71%)。分子量计算值:675.25,实测值C/Z:675.2。
实施例B14:化合物5B-321的制备
化合物14-1的制备
将对氯
苯硼酸(31.2g,0.2mol),化合物13-3(56.2g,0.2mmol),碳酸钾(82.8g,0.6mol)加入含1,4-二氧六环/水(900mL/300mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.31g,2mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物14-1(46.4g,收率65%)。
化合物11-2的制备
将化合物14-2(35.7g,0.1mol),硼酸频哪醇酯(38.1g,0.15mol),磷酸钾(41.4g,0.3mol)加入含1,4-二氧六环(1L)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(916mg,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物14-2(31.4g,收率70%)。
化合物5B-321的制备
将9-溴-10-萘基蒽(5.73g,15mmol),化合物14-2(6.74g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物5B-321(7.5g,收率80%)。分子量计算值625.23,实测值C/Z:625.2。
实施例B15:
化合物5B-401的制备
化合物15-1的制备
将化合物
13-1(19.5g,0.1mol),原甲酸三甲酯(150ml,做溶剂)加入烧瓶中,搅拌下加热至回流反应3小时,TLC监控反应终点。减压旋除溶剂,乙醇煮洗,抽滤干燥得到化合物15-1(16.8g,收率82%)。
化合物15-2的制备
将对氯
苯硼酸(14g,90.2mmol),化合物15-1(16.8g,82mmol),碳酸钾(33.9g,246mmol)加入含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(947mg,0.82mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物15-2(16.1g,收率70%)。
化合物15-3的制备
将化合物15-2(16.1g,57.4mmol),硼酸频哪醇酯(21.9g,86.1mmol),磷酸钾(23.8g,172mmol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(550mg,0.6mmol),Sphos(738mg,1.8mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物15-3(19.1g,收率74%)。
化合物5B-401的制备
将
9-(4-联苯基)-10-溴蒽(6.12g,15mmol),化合物15-3(6.74g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物5B-401(7.1g,收率82%)。分子量计算值:575.21,实测值C/Z:575.2。
实施例B16:
化合物6B-121的制备
化合物16-1的制备
将
2,4-二氯吡啶并[3,4-d]嘧啶(49.8g,250mmol),28%氨水(94g,750mmol加入含500mL乙醇的烧瓶中,室温搅拌下搅拌反应48小时。TLC监控反应终点。过滤析出的固体,乙醇淋洗,干燥得到化合物16-1(27g,收率60%)。
化合物16-2的制备
将化合物16-1(27g,0.15mol),溴代苯乙酮(32.7g,0.165mol)加入含有400mL DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物16-2(31.5g,75%)。
化合物6B-121的制备
将化合物16-2(5g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热至80℃反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物6B-121(9.3g,收率77%)。分子量计算值:674.25,实测值C/Z:674.2。
实施例B17:
化合物6B-321的制备
化合物17-1的制备
将对氯
苯硼酸(31.2g,0.2mol),化合物16-2(56g,0.2mmol),碳酸钾(82.8g,0.6mol)加入含1,4-二氧六环/水(900mL/300mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.31g,2mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物17-1(47g,收率66%)。
化合物17-2的制备
将化合物16-2(35.6g,0.1mol),硼酸频哪醇酯(38.1g,0.15mol),磷酸钾(41.4g,0.3mol)加入含1,4-二氧六环(1L)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(916mg,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物17-2(31.8g,收率71%)。
化合物6B-321的制备
将9-溴-10-萘基蒽(5.73g,15mmol),化合物14-2(6.73g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物6B-321(7.8g,收率83%)。分子量计算值624.23,实测值C/Z:624.2。
实施例B18:
化合物6B-411的制备
化合物18-1的制备
将化合物16-1(90g,0.5mol),溴丙酮(81.6g,0.6mmol)加入含有700mL DMF的烧瓶中,搅拌下加热至100℃反应15小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体,用乙醇淋洗,干燥后柱层析得到得棕黄色固体化合18-1(76.3g,70%)。
化合物18-2的制备
将对氯
苯硼酸(34.3g,220mmol),化合物18-1(43.6g,200mmol),碳酸钾(82.8g,600mmol)加入含1,4-二氧六环/水(600mL/200mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.3g,0.2mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。抽滤所得固体,柱层析分离提纯得到化合物18-2(45.3g,收率77%)。
化合物18-3的制备
将化合物18-2(29.4g,100mmol),硼酸频哪醇酯(38.1g,150mmol),磷酸钾(41.4g,300mmol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(1.15g,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物18-3(30.9g,收率80%)。
化合物6B-411的制备
将
9-(4-联苯基)-10-溴蒽(6.12g,15mmol),化合物18-3(5.79g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物6B-411(7.1g,收率81%)。分子量计算值:588.23,实测值C/Z:588.2。
实施例B19:
化合物7A-121的制备
化合物19-1的制备
在烧瓶中将2,4-二氯噻吩并[2,3-d]嘧啶(510g,2.5mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物19-1(375g,75%)。
化合物19-2的制备
将化合物19-1(375g,1.875mol)加入含有4L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(260g,2.45mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物19-2(351g,65%)。
化合物19-3的制备
将化合物19-2(351g,1.22mol)加入含有7L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(471g,1.46mol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。抽滤析出的固体,正己烷淋洗,干燥得淡棕黄色固体化合物19-3(251g,72%)。
化合物7A-121的制备
将化合物19-3(5.1g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4 (208mg,0.18mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤析出的黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物7A-121(8.8g,收率72%)。分子量计算值:680.20,实测值C/Z:680.2。
实施例B20:
化合物7A-321的制备
化合物20-1的制备
将对氯
苯硼酸(31.2g,0.2mol),化合物19-3(57.2g,0.2mmol),碳酸钾(82.8g,0.6mol)加入含1,4-二氧六环/水(900mL/300mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.31g,2mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物20-1(47g,收率65%)。
化合物20-2的制备
将化合物20-1(36.2g,0.1mol),硼酸频哪醇酯(38.1g,0.15mol),磷酸钾(41.4g,0.3mol)加入含1,4-二氧六环(1L)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(916mg,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物20-2(32.6g,收率72%)。
化合物7A-321的制备
将9-溴-10-萘基蒽(5.73g,15mmol),化合物20-2(6.81g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物7A-321(7.6g,收率81%)。分子量计算值630.19,实测值C/Z:630.2。
实施例B21:
化合物7A-401的制备
化合物21-1的制备
将化合物19-
2(20.2g,0.1mol),原甲酸三甲酯(150ml,做溶剂)加入烧瓶中,搅拌下加热至回流反应3小时,TLC监控反应终点。减压旋除溶剂,乙醇煮洗,抽滤干燥得到化合物21-1(17.4g,收率83%)。
化合物21-2的制备
将对氯
苯硼酸(14g,90.2mmol),化合物21-1(17.2g,82mmol),碳酸钾(33.9g,246mmol)加入含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(947mg,0.82mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物21-2(16.9g,收率72%)。
化合物21-3的制备
将化合物21-2(16.9g,59mmol),硼酸频哪醇酯(22.5g,88.6mmol),磷酸钾(24.4g,177mmol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(550mg,0.6mmol),Sphos(738mg,1.8mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物21-3(15.6g,收率70%)。
化合物7A-401的制备
将
9-(4-联苯基)-10-溴蒽(6.12g,15mmol),化合物15-3(5.67g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4 (173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物7A-401(7.4g,收率85%)。分子量计算值:580.17,实测值C/Z:580.2。
实施例B22:化合物8A-121的制备
化合物22-1的制备
将2,4-二氯噻吩并[2,3-d]嘧啶(51g,250mmol),28%氨水(94g,750mmol加入含500mL乙醇的烧瓶中,室温搅拌下搅拌反应48小时。TLC监控反应终点。过滤析出的固体,乙醇淋洗,干燥得到化合物22-1(29g,收率63%)。
化合物22-2的制备
将化合物22-1(27.8g,0.15mol),溴代苯乙酮(32.7g,0.165mol)加入含有400mL DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物22-2(32.5g,76%)。
化合物8A-121的制备
将化合物22-2(5.1g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热至80℃反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物8A-121(9.2g,收率75%)。分子量计算值:679.21,实测值C/Z:679.2。
实施例B23:
化合物8A-321的制备
化合物23-1的制备
将对氯
苯硼酸(15.6g,0.1mol),化合物22-2(28.5g,0.1mmol),碳酸钾(41.4g,0.3mol)加入含1,4-二氧六环/水(450mL/150mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(1.15g,1mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物23-1(24.2g,收率67%)。
化合物23-2的制备
将化合物23-1(23.2g,0.067mol),硼酸频哪醇酯(25.4g,0.1mol),磷酸钾(27.7g,0.2mol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(641mg,0.7mmol),Sphos(861mg,2.1mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物23-2(22.5g,收率74%)。
化合物8A-321的制备
将9-溴-10-萘基蒽(5.73g,15mmol),化合物23-2(6.8g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物8A-321(7.5g,收率80%)。分子量计算值629.19,实测值C/Z:629.2。
实施例B24:
化合物8A-411的制备
化合物24-1的制备
将化合物22-1(92.5g,0.5mol),溴丙酮(81.6g,0.6mmol)加入含有700mL DMF的烧瓶中,搅拌下加热至100℃反应15小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体,用乙醇淋洗,干燥后柱层析得到得棕黄色固体化合24-1(79.2g,71%)。
化合物24-2的制备
将对氯
苯硼酸(34.3g,220mmol),化合物24-1(44.6g,200mmol),碳酸钾(82.8g,600mmol)加入含1,4-二氧六环/水(600mL/200mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.3g,0.2mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。抽滤所得固体,柱层析分离提纯得到化合物24-2(44.9g,收率75%)。
化合物24-3的制备
将化合物24-2(29.9g,100mmol),硼酸频哪醇酯(38.1g,150mmol),磷酸钾(41.4g,300mmol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(1.15g,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物24-3(30.6g,收率77%)。
化合物8A-411的制备
将
9-(4-联苯基)-10-溴蒽(6.12g,15mmol),化合物24-3(5.86g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物8A-411(7.3g,收率82%)。分子量计算值:593.19,实测值C/Z:593.2。
实施例B25:
化合物9A-121的制备
化合物25-1的制备
在烧瓶中将2,4-二氯噻吩并[3,2-d]嘧啶(510g,2.5mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物25-1(365g,73%)。
化合物25-2的制备
将化合物25-1(365g,1.825mol)加入含有4L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(251g,2.37mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物25-2(347g,66%)。
化合物25-3的制备
将化合物25-2(347g,1.2mol)加入含有7L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(465g,1.44mol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。抽滤析出的固体,正己烷淋洗,干燥得淡棕黄色固体化合物25-3(240g,70%)。
化合物9A-121的制备
将化合物25-3(5.1g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤析出的黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物9A-121(9.1g,收率74%)。分子量计算值:680.20,实测值C/Z:680.2。
实施例B26:
化合物9A-321的制备
化合物26-1的制备
将对氯
苯硼酸(15.6g,0.1mol),化合物25-3(28.6g,0.1mmol),碳酸钾(41.4g,0.3mol)加入含1,4-二氧六环/水(450mL/150mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(1.15g,1mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物26-1(24.6g,收率68%)。
化合物26-2的制备
将化合物26-1(24.6g,0.067mol),硼酸频哪醇酯(25.4g,0.1mol),磷酸钾(27.7g,0.2mol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(641mg,0.7mmol),Sphos(861mg,2.1mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物26-2(21.3g,收率70%)。
化合物9A-321的制备
将9-溴-10-萘基蒽(5.73g,15mmol),化合物26-2(6.8g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物9A-321(8.5g,收率83%)。分子量计算值630.19,实测值C/Z:630.2。
实施例B27:
化合物9A-401的制备
化合物27-1的制备
将化合物25-
2(20.2g,0.1mol),原甲酸三甲酯(150ml,做溶剂)加入烧瓶中,搅拌下加热至回流反应3小时,TLC监控反应终点。减压旋除溶剂,乙醇煮洗,抽滤干燥得到化合物27-1(16.8g,收率80%)。
化合物27-2的制备
将对氯
苯硼酸(13.7g,88mmol),化合物27-1(16.8g,80mmol),碳酸钾(33.1g,240mmol)加入含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(924mg,0.8mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物27-2(16g,收率70%)。
化合物27-3的制备
将化合物27-2(16g,56mmol),硼酸频哪醇酯(21.3g,84mmol),磷酸钾(23.2g,168mmol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(550mg,0.6mmol),Sphos(738mg,1.8mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物27-3(15.7g,收率74%)。
化合物9A-401的制备
将
9-(4-联苯基)-10-溴蒽(6.12g,15mmol),化合物27-3(5.67g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物9A-401(7.7g,收率88%)。分子量计算值:580.17,实测值C/Z:580.2。
实施例B28:
化合物10A-121的制备
化合物28-1的制备
将2,4-二氯噻吩并[3,2-d]嘧啶(51g,250mmol),28%氨水(94g,750mmol加入含500mL乙醇的烧瓶中,室温搅拌下搅拌反应48小时。TLC监控反应终点。过滤析出的固体,乙醇淋洗,干燥得到化合物28-1(29.6g,收率64%)。
化合物28-2的制备
将化合物28-1(29.6g,0.16mol),溴代苯乙酮(34.8g,0.176mol)加入含有400mL DMF的烧瓶中,搅拌下加热至100℃反应20小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体用乙醇淋洗,干燥后柱层析得到得浅棕黄色固体化合物28-2(32.8g,72%)。
化合物10A-121的制备
将化合物28-2(5.1g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热至80℃反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物10A-121(9.4g,收率77%)。分子量计算值:679.21,实测值C/Z:679.2
实施例B29:
化合物10A-321的制备
化合物29-1的制备
将对氯
苯硼酸(15.6g,0.1mol),化合物28-2(28.5g,0.1mmol),碳酸钾(41.4g,0.3mol)加入含1,4-二氧六环/水(450mL/150mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(1.15g,1mmol)。加毕,搅拌下80℃反应12小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物29-1(24.9g,收率69%)。
化合物29-2的制备
将化合物29-1(24.9g,0.069mol),硼酸频哪醇酯(25.4g,0.1mol),磷酸钾(27.7g,0.2mol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(641mg,0.7mmol),Sphos(861mg,2.1mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。过滤所得固体,二氯甲烷溶解,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物29-2(23.4g,收率75%)。
化合物10A-321的制备
将9-溴-10-萘基蒽(5.73g,15mmol),化合物29-2(6.8g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物10A-321(7.6g,收率81%)。分子量计算值629.19,实测值C/Z:629.2。
实施例B30:
化合物10A-411的制备
化合物30-1的制备
将化合物28-1(92.5g,0.5mol),溴丙酮(81.6g,0.6mmol)加入含有700mL DMF的烧瓶中,搅拌下加热至100℃反应15小时,TLC显示反应完全。降至室温,加水析出固体,过滤所得固体,用乙醇淋洗,干燥后柱层析得到得棕黄色固体化合30-1(78g,70%)。
化合物30-2的制备
将对氯
苯硼酸(34.3g,220mmol),化合物30-1(44.6g,200mmol),碳酸钾(82.8g,600mmol)加入含1,4-二氧六环/水(600mL/200mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(2.3g,0.2mmol)。加毕,搅拌下80℃反应8小时,TLC监控反应终点。抽滤所得固体,柱层析分离提纯得到化合物30-2(44.9g,收率75%)。
化合物30-3的制备
将化合物30-2(29.9g,100mmol),硼酸频哪醇酯(38.1g,150mmol),磷酸钾(41.4g,300mmol)加入含1,4-二氧六环(500mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(1.15g,1mmol),Sphos(1.23g,3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。抽滤,固体用二氯甲烷溶解;液相水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯得到化合物30-3(27.3g,收率70%)。
化合物10A-411的制备
将
9-(4-联苯基)-10-溴蒽(6.12g,15mmol),化合物30-3(5.86g,15mmol),碳酸钾(6.2g,45mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(173mg,0.15mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析得到黄色固体化合物10A-411(7.6g,收率85%)。分子量计算值:593.19,实测值C/Z:593.2。
本申请第四优选实施方案的具体化合物的合成实施例如下:
实施例D1:化合物C2的制备
化合物1-1的制备
在烧瓶中将2,4-二氯喹唑啉(500g,2.5mol)溶于10L乙醇后,搅拌下在5℃滴加水合肼(470g,7.5mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤析出的固体,用水和乙醇分别洗涤,晾干得到类白色固体化合物1-1(415g,86%)。
化合物1-2的制备(参考文献J.Heterocyclic chem.27,497,1990)
将化合物1-1(200g,1.03mol)加入含有2L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(120g,1.13mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物1-2(184g,63%)。
化合物1-3的制备
将化合物1-2(184g,652.4mmol)加入含有4L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(252g,782.9mmol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。加入4L正己烷搅拌5分钟后抽滤析出的固体,正己烷淋洗,干燥得淡棕黄色固体化合物1-3(130g,71%)。
化合物1-4的制备
将2-溴-9,10-二(B-萘基)-蒽(508g,1mol),硼酸频哪醇酯(381g,1.5mol),醋酸钾(294g,3mol)加入含1,4-二氧六环(3L)烧瓶中,室温搅拌下置换氮气后加入Pd(dppf
2)Cl
2(7.32g,0.01mol)。加毕,搅拌回流反应24小时,TLC监控反应终点。过滤析出的固体。水洗,干燥得到化合物1-4(500.4g,收率90%)。
化合物C2的制备
将化合物1-3(5g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤析出的黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物C2(8.5g,收率70%)。分子量计算值:674.25,实测值C/Z:674.2。
实施例D2:化合物C14的制备
化合物2-1的制备
将化合物1-1(20g,103mmol)加入含有200mL乙醇的烧瓶中,室温搅拌下加入二苯并呋喃-2-甲醛(24.5g,125mmol),加毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得黄色固体化合物2-1(25.6g,67%)。
化合物2-2的制备
将化合物2-1(25.6g,69mmol)加入含有200L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(26.7g,82.8mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入200mL正己烷,搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥得棕黄色固体化合物2-2(17.8g,70%)。
化合物C14的制备
将化合物2-2(6.66g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所 得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物C14(10g,收率73%)。分子量计算值:764.26,实测值C/Z:764.3。
实施例D3:化合物C26的制备
化合物3-1的制备
在烧瓶中将2,4-二氯-7-溴喹唑啉(50g,0.181mol)溶于1L乙醇后,搅拌下在5℃滴加水合肼(34g,0.543mol,80%水溶液),滴加过程保持温度低于10℃。滴加完毕自然升至室温反应1小时,抽滤所得固体,用水和乙醇分别洗涤固体,晾干得到淡黄色固体化合物3-1(39.4g,80%)。
化合物3-2的制备
将化合物3-1(39.4g,0.145mol)加入含有0.4L乙醇的烧瓶中,室温搅拌下滴加苯甲醛(18.4g,0.174mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得淡黄色固体化合物3-2(34g,65%)。
化合物3-3的制备
将化合物3-2(34g,94.3mmol)加入含有0.6L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(36.4g,113.2mmol),加毕,继续搅拌反应1.5小时,TLC显示反应完全。加入0,6L正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥得淡黄色固体化合物3-3(23.6g,70%)。
化合物3-4的制备
将化合物3-3(6.44g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所 得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物3-4(10.2g,收率75%)。
化合物C26的制备
将苯硼酸(1.65g,13.56mmol),化合物3-4(10.2g,13.56mmol),碳酸钾(5.6g,40.7mmol)加入含有1,4-二氧六环/水(150mL/50mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(157mg,0.136mmol)。加毕,搅拌回流反应8小时,TLC监控反应终点。过滤析出的固体。液相分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。合并固体粗品,柱层析分离提纯(洗脱剂为二氯甲烷),得到化合物C26(7.1g,收率70%)。分子量计算值:750.28,实测值C/Z:750.3。
实施例D4:化合物C32的制备
化合物4-1的制备
将化合物1-1(20g,0.103mol)加入含有0.4L乙醇的烧瓶中,室温搅拌下加入对溴苯甲醛(22.8g,0.124mol),滴加完毕继续搅拌反应30分钟,过滤所得固体,分别用乙醇和正己烷淋洗,干燥得淡黄色固体化合物4-1(24.1g,65%)。
化合物4-2的制备
将化合物4-1(24.1g,66.9mmol)加入含有0.4L乙醇的烧瓶中,室温搅拌下分批加入醋酸碘苯(225.9g,80.3mmol),加毕继续搅拌反应1.5小时,TLC显示反应完全。加入0.4L正己烷搅拌5分钟后抽滤所得固体,正己烷淋洗,干燥得淡棕黄色固体化合物4-2(16.8g,70%)。
化合物4-3的制备
将苯硼酸(5.71g,46.83mmol),化合物4-2(16.8g,46.83mmol),碳酸钾(19.4g,140.5mmol)加入含有1,4-二氧六环/水(150mL/50mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(541mg,0.468mmol)。加毕,搅拌回流反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=5∶1~3∶1),得到化合物4-3(12.5g,收率67%)。
化合物C32的制备
将化合物4-3(7.2g,18mmol),化合物1-4(10g,18mmol),碳酸钾(7.45g,54mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(208mg,0.18mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物C32(10.8g,收率80%)。分子量计算值:750.28,实测值C/Z:750.3。
实施例D5:化合物C43的制备
化合物5-1的制备
将对氯苯硼酸(8.36g,53.6mmol),化合物1-3(15g,53.6mmol),碳酸钾(22.2g,160.8mmol)加入含1,4-二氧六环/水(300mL/100mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(619mg,0.536mmol)。加毕,搅拌回流反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=5∶1~2∶1),得到化合物5-1(14.1g,收率74%)。
化合物5-2的制备
将化合物5-1(14.1g,39.7mmol),硼酸频哪醇酯(15.1g,59.5mmol),磷酸钾(25.2g,119.1mmol)加入含1,4-二氧六环(300mL)烧瓶中,室温搅拌下置换氮气后加入Pd
2(dba)
3(364mg,0.397mmol),Sphos(488mg,1.191mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=3∶1),干燥得到化合物5-2(15.1g,收率85%)。
化合物C43的制备
将9-溴-10-萘基蒽(7.64g,20mmol),化合物5-2(8.96g,20mmol),碳酸钾(8.3g,60mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(231mg,0.2mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物C43(10.2g,收率82%)。分子量计算值:624.23,实测值C/Z:624.2。
实施例D6:化合物C53的制备
化合物6-1的制备
将化合物4-3(15g,37.5mmol),硼酸频哪醇酯(14.3g,56.3mmol),醋酸钾(11g,112.5mol)加入含1,4-二氧六环(300mL)烧瓶中,室温搅拌下置换氮气后加入Pd(dppf
2)Cl
2(275mg,0.375mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。过滤析出的固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为石油醚∶二氯甲烷=2∶1),干燥得到化合物6-1(14.1g,收率84%)。
化合物C53的制备
将9-溴-10-萘基蒽(7.64g,20mmol),化合物6-1(9g,20mmol),碳酸钾(8.3g,60mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(231mg,0.2mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物C53(10.7g,收率86%)。分子量计算值:624.23,实测值C/Z:624.2。
实施例D7:化合物C63的制备
化合物7-1的制备
将苯硼酸(3.66g,30mmol),化合物3-3(10.7g,30mmol),碳酸钾(12.4g,90mmol)加入含有1,4-二氧六环/水(150mL/50mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(347mg,0.3mmol)。加毕,搅拌回流反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=5∶1),得到化合物7-1(7.8g,收率65%)。
化合物7-2的制备
将化合物7-1(7.8g,19.5mmol),硼酸频哪醇酯(7.44g,29.3mmol),醋酸钾(5.7g,58.5mol)加入含1,4-二氧六环(200mL)烧瓶中,室温搅拌下置换氮气后加入Pd(dppf
2)Cl
2(143mg,0.195mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=3∶1),干燥得到化合物7-2(7.7g,收率88%)。
化合物C63的制备
将9-溴-10-萘基蒽(6.57g,17.2mmol),化合物6-1(7.7g,17.2mmol),碳酸钾(7.1g,51.6mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(200mg,0.17mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物C63(9.3g,收率87%)。分子量计算值:624.23,实测值C/Z:624.2。
实施例D8:化合物C75的制备
化合物8-1的制备
将苯硼酸(3.66g,30mmol),2,7-二溴菲(10g,30mmol),碳酸钾(12.4g,90mmol)加入含有1,4-二氧六环/水(150mL/50mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(347mg,0.3mmol)。加毕,搅拌回流反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=10∶1),得到化合物8-1(8.5g,收率85%)。
化合物C75的制备
将化合物8-1(8.5g,25.5mmol),化合物7-2(11.4g,25.5mmol),碳酸钾(10.5g,76.5mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(300mg,0.26mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物C75(12.9g,收率88%)。分子量计算值:574.22,实测值C/Z:574.2。
实施例D9:化合物C89的制备
化合物9-1的制备
将化合物8-1(9.96g,30mmol),硼酸频哪醇酯(11.43g,45mmol),醋酸钾(8.82g,90mol)加入含1,4-二氧六环(200mL)烧瓶中,室温搅拌下置换氮气后加入Pd(dppf
2)Cl
2(220mg,0.3mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为石油醚∶二氯甲烷=5∶1),干燥得到化合物9-1(9.12g,收率80%)。
化合物C89的制备
将化合物9-1(9.12g,24mmol),化合物1-3(6.72g,24mmol),碳酸钾(9.94g,72mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(277mg,0.24mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷)得到黄色固体化合物C89(9.7g,收率81%)。分子量计算值:498.18,实测值C/Z:498.2。
实施例D10:化合物C94的制备
化合物10-1的制备
将4-吡啶硼酸(3.69g,30mmol),2,6-二溴芘(10.74g,30mmol),碳酸钾(12.4g,90mmol)加入含有1,4-二氧六环/水(150mL/50mL)烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(347mg,0.3mmol)。加毕,搅拌回流反应8小时,TLC监控反应终点。分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为二氯甲烷),得到化合物10-1(8.57g,收率80%)。
化合物10-2的制备
将化合物10-1(8.57g,24mmol),硼酸频哪醇酯(9.14g,36mmol),醋酸钾(9.94g,72mol)加入含1,4-二氧六环(200mL)烧瓶中,室温搅拌下置换氮气后加入Pd(dppf
2)Cl
2(176mg,0.24mmol)。加毕,搅拌回流反应24小时,TLC监控反应终点。水洗分液,水相用二氯甲烷萃取,合并有机相,无水硫酸钠干燥,过滤,减压旋除溶剂。柱层析分离提纯(洗脱剂为二氯甲烷∶甲醇=50∶1),干燥得到化合物10-2(6.81g,收率70%)。
化合物C94的制备
将化合物10-2(6.81g,16.8mmol),化合物1-3(4.7g,16.8mmol),碳酸钾(6.96g,50.4mmol)加入含有1,4-二氧六环∶水(150mL∶50mL)的烧瓶中,室温搅拌下置换氮气后加入Pd(PPh
3)
4(196mg,0.17mmol)。加毕,氮气氛搅拌下加热回流反应12小时,TLC显示反应完全。过滤所得黄色固体。二氯甲烷溶解,无水硫酸钠干燥,柱层析(洗脱剂为二氯甲烷∶甲醇=30∶1)得到黄色固体化合物C94(7.3g,收率83%)。分子量计算值:523.18,实测值C/Z:523.2。
采用质谱分析,对化合物C1至C97进行表征,数据见表3所示。
表3 合成实施例化合物表征数据
化合物 | 分子式 | 计算值 | 实测值 |
C1 | C41H26N4 | 574.22 | 574.2 |
C2 | C49H30N4 | 674.25 | 674.2 |
C3 | C53H34N4 | 726.28 | 726.3 |
C4 | C57H34N4 | 774.28 | 774.3 |
C5 | C57H34N4 | 774.28 | 774.3 |
C6 | C50H32N4 | 688.26 | 688.3 |
C7 | C50H29N5 | 699.24 | 699.2 |
C8 | C48H29N5 | 675.24 | 675.2 |
C9 | C48H29N5 | 675.24 | 675.2 |
C10 | C48H29N5 | 675.24 | 675.2 |
C11 | C47H28N4O | 664.23 | 664.2 |
C12 | C47H28N4O | 664.23 | 664.2 |
C13 | C47H28N4S | 680.20 | 680.2 |
C14 | C55H32N4O | 764.26 | 764.3 |
C15 | C58H38N4 | 790.31 | 790.3 |
C16 | C53H32N4 | 724.26 | 724.3 |
C17 | C53H32N4 | 724.26 | 724.3 |
C18 | C55H34N4 | 750.28 | 750.3 |
C19 | C55H34N4 | 750.28 | 750.3 |
C20 | C55H34N4 | 750.28 | 750.3 |
C21 | C59H36N4 | 800.29 | 800.3 |
C22 | C59H36N4 | 800.29 | 800.3 |
C23 | C57H34N4 | 774.28 | 774.3 |
C24 | C61H38N4 | 826.31 | 826.3 |
C25 | C61H38N4 | 826.31 | 826.3 |
C26 | C55H34N4 | 750.28 | 750.3 |
C27 | C59H36N4 | 800.29 | 800.3 |
C28 | C54H33N5 | 751.27 | 751.3 |
C29 | C54H33N5 | 751.27 | 751.3 |
C30 | C54H33N5 | 751.27 | 751.3 |
C31 | C47H30N4 | 650.25 | 650.2 |
C32 | C55H34N4 | 750.28 | 750.3 |
C33 | C59H38N4 | 802.31 | 802.3 |
C34 | C63H38N4 | 850.31 | 850.3 |
C35 | C63H38N4 | 850.31 | 850.3 |
C36 | C54H33N5 | 751.27 | 751.3 |
C37 | C54H33N5 | 751.27 | 751.3 |
C38 | C54H33N5 | 751.27 | 751.3 |
C39 | C54H33N5 | 751.27 | 751.3 |
C40 | C54H33N5 | 751.27 | 751.3 |
C41 | C41H26N4 | 574.22 | 574.2 |
C42 | C45H28N4 | 624.23 | 624.2 |
C43 | C45H28N4 | 624.23 | 624.2 |
C44 | C47H30N4 | 650.25 | 650.2 |
C45 | C53H34N4 | 726.28 | 726.3 |
C46 | C44H27N5 | 625.23 | 625.2 |
C47 | C44H27N5 | 625.23 | 625.2 |
C48 | C44H27N5 | 625.23 | 625.2 |
C49 | C49H30N4 | 674.25 | 674.2 |
C50 | C51H32N4 | 700.26 | 700.3 |
C51 | C41H26N4 | 574.22 | 574.2 |
C52 | C45H28N4 | 624.23 | 624.2 |
C53 | C45H28N4 | 624.23 | 624.2 |
C54 | C47H30N4 | 650.25 | 650.2 |
C55 | C53H34N4 | 726.28 | 726.3 |
C56 | C44H27N5 | 625.23 | 625.2 |
C57 | C44H27N5 | 625.23 | 625.2 |
C58 | C44H27N5 | 625.23 | 625.2 |
C59 | C49H30N4 | 674.25 | 674.2 |
C60 | C51H32N4 | 700.26 | 700.3 |
C61 | C41H26N4 | 574.22 | 574.2 |
C62 | C45H28N4 | 624.23 | 624.2 |
C63 | C45H28N4 | 624.23 | 624.2 |
C64 | C47H30N4 | 650.25 | 650.2 |
C65 | C53H34N4 | 726.28 | 726.3 |
C66 | C44H27N5 | 625.23 | 625.2 |
C67 | C44H27N5 | 625.23 | 625.2 |
C68 | C44H27N5 | 625.23 | 625.2 |
C69 | C44H27N5 | 625.23 | 625.2 |
C70 | C44H27N5 | 625.23 | 625.2 |
C71 | C37H24N4 | 524.20 | 524.2 |
C72 | C37H24N4 | 524.20 | 524.2 |
C73 | C41H26N4 | 574.22 | 574.2 |
C74 | C41H26N4 | 574.22 | 574.2 |
C75 | C41H26N4 | 574.22 | 574.2 |
C76 | C37H22N4 | 522.18 | 522.2 |
C77 | C39H24N4 | 548.20 | 548.2 |
C78 | C38H25N5 | 551.21 | 551.2 |
C79 | C36H25N5 | 525.20 | 525.2 |
C80 | C37H24N6 | 552.21 | 552.2 |
C81 | C37H24N6 | 552.21 | 552.2 |
C82 | C36H23N5 | 525.20 | 525.2 |
C83 | C36H23N5 | 525.20 | 525.2 |
C84 | C39H26N4 | 550.22 | 550.2 |
C85 | C37H24N4 | 524.20 | 524.2 |
C86 | C36H26N4 | 514.22 | 514.2 |
C87 | C35H25N5 | 515.21 | 515.2 |
C88 | C35H25N5 | 515.21 | 515.2 |
C89 | C35H22N4 | 498.18 | 498.2 |
C90 | C34H21N5 | 499.18 | 499.2 |
C91 | C39H24N4 | 548.20 | 548.2 |
C92 | C38H23N5 | 549.20 | 549.2 |
C93 | C37H22N4 | 522.18 | 522.2 |
C94 | C36H21N5 | 523.18 | 523.2 |
C95 | C41H24N4 | 572.20 | 572.2 |
C96 | C37H22N4O | 538.18 | 538.2 |
C97 | C37H22N4S | 554.16 | 554.2 |
器件实施例
本申请第一优选实施方案的具体化合物的器件实施例如下:
应用以下器件结构进行OLED器件评测:ITO(120nm)/HI-1(80nm)/HI-2(5nm)/HT-1(10nm)/HT-2(60nm)/Host:D-1(97∶3,40nm)/ET-1:EI-1(50∶50,40nm)/EI-1(2nm)/Al(80nm)(上述缩写分别对应ITO阳极/空穴注入层1/空穴传输层2/空穴传输层1/空穴传输层2/发光层/电子传输层/电子注入层/Al阴极,以下上述缩写的意义相同),下式示出了器件中各功能层所使用材料的结构式:
上述有机电致发光材料都是本领域常用的材料,本领域人员基于公知方法可以自行制备或商业购买。
器件实施例1-1.以化合物1I-12作为主体材料
将涂布了ITO(120nm)透明导电层的玻璃板在商用清洗剂中超声处理,在去离子水中冲洗,在丙酮∶乙醇混合溶剂(体积比1∶1)中超声除油,在洁净环境下烘烤至完全除去水份,用紫外光和臭氧清洗,并用Satella(ULVAC)的低能阳离子束轰击表面;
把上述带有阳极的玻璃基片置于真空腔内,抽真空至1×10
-5~9×10
-3Pa,在上述阳极层膜上真空蒸镀化合物HI-1,形成厚度为80nm的空穴注入层1;在空穴注入层1之上真空蒸镀化合物HI-2,形成厚度为5nm空穴注入层2;在空穴注入层2之上真空蒸镀化合物HT-1,形成厚度为10nm空穴传输层1;在空穴传输层1上真空蒸镀化合物HT-2形成厚度为80nm空穴传输层2;在空穴传输层2上形成电致发光层,具体操作为:将作为发光层主体的化合物C1放置在真空气相沉积设备的单元中,将作为掺杂剂的化合物D-1放置在真空气相沉积设备的另一单元中,以不同的速率同时蒸发两种材料,D-1与主体材料化合物1I-12的质量比为3∶97,蒸镀总膜厚为40nm;然后将化合物ET-1和化合物LiQ分别放入真空气相沉积设备的2个单元中,以1∶1的比例进行蒸发,并且每一个沉积50Wt%的掺杂量以在发光层上形成厚度为40nm的电子传输层。接下来,将化合物LiQ作为厚度为2nm的电子注入层沉积在电子传输层上后,通过另一个真空气相沉积设备将厚度为80nm的Al阴极沉积在电子注入层上。从而形成OLED器件。使用前,在10-6torr下通过真空升华提纯设备提纯用于制作OLED器件的所有材料。
器件实施例1-2.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物1II-12。
器件实施例1-3.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物1II-63。
器件实施例1-4.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物1II-327。
器件实施例1-5.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物2I-12。
器件实施例1-6.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物2II-63。
器件实施例1-7.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物2II-327。
器件实施例1-8.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物3I-12。
器件实施例1-9.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物3I-327。
器件实施例1-10.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物3II-327。
器件实施例1-11.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物4I-12。
器件实施例1-12.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物4II-327。
器件实施例1-13.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物4I-63。
器件实施例1-14.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物5BII-327。
器件实施例1-15.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物6BI-12。
器件实施例1-16.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物6BI-63。
器件实施例1-17.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物7AII-327。
器件实施例1-18.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物8AI-12。
器件实施例1-19.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物9AII-327。
器件实施例1-20.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物10AI-12。
器件比较例1-1.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为化合物CBP。
器件比较例1-2.
采用与实施例1-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物1I-12替换为业内常用的参比化合物H-1。
在同样亮度下,使用数字源表及亮度计测定器件实施例1-1~1-20以及器件对比例1-1~1-2中制备得到的有机电致发光器件的驱动电压和电流效率以及器件的寿命。具体而言,以每秒0.1V的速率提升电压,测定当亮度达到1000cd/m
2时的电压即驱动电压,同时测出此时的电流密度;亮度与电流密度的比值即为电流效率;T95的寿命测试使用亮度计在5000cd/m
2亮度下,保持恒定的电流,测量其亮度降为4750cd/m
2的时间,单位为小时。测定结果结果见表4。
表4 第一优选实施方案的化合物用作主体材料时器件的测定结果
从表4中的数据可以看出,在有机电致发光器件结构中其他材料相同的情况下,器件实施例1-1~1-20与器件比较例1-1相比,差别在于,器件实施例1-1~1-20采用了本实施方案的系列化合物代替对比器件比较例1-1中CBP作为红光主体材料。由于材料本身同时具有给电子基团和拉电子基团,使得材料具有很好的双载流子传输性能,能够有效的拓宽激子复合区域,使得三线态激 子之间的淬灭显著降低,因而可以有效的提高发光效率,器件数据显示,采用本实施方案材料作为发光层主体材料能够降低器件工作电压和较高的电流效率显示了本实施方案中材料的优异的载流子传输平衡性以及能级匹配性。
与器件比较例1-1相比较,使用本实施方案的新型有机材料用于有机电致发光器件中主体材料,相对于CBP作为主体材料其电压降低了50%以上。同时具有更好的电压-电流-发光特性,更高的效率。尤其是器件的寿命较器件比较例1中的器件寿命有了非常显著提高。
与器件比较例1-2相比较,使用本实施方案的新型有机材料用于有机电致发光器件中主体材料,相对于H-1作为主体材料其电压相当或有所降低,效率和寿命也有不同程度的提高。
本申请第二优选实施方案的具体化合物的器件实施例如下:
应用以下器件结构进行OLED器件评测:ITO(120nm)/HI-1(80nm)/HI-2(5nm)/HT-1(10nm)/HT-2(60nm)/Host:D-1(97∶3,40nm)/ET-1:EI-1(50∶50,40nm)/EI-1(2nm)/Al(80nm)(上述缩写分别对应阳极/第一空穴注入层/第二空穴注入层/第一空穴传输层/第二空穴传输层/发光层/电子传输层/电子注入层/阴极,以下上述缩写的意义相同),下式示出了器件中各功能层所使用材料的结构式:
上述有机电致发光材料都是本领域常用的材料,本领域人员基于公知方法可以自行制备或商业购买。
器件实施例2-1.以化合物C1作为主体材料
将涂布了ITO(120nm)透明导电层的玻璃板在商用清洗剂中超声处理,在去离子水中冲洗,在丙酮∶乙醇混合溶剂(体积比1∶1)中超声除油,在洁净环境下烘烤至完全除去水份,用紫外光和臭氧清洗,并用Satella(ULVAC)的低能阳离子束轰击表面;
把上述带有阳极的玻璃基片置于真空腔内,抽真空至1×10
-5~9×10
-3Pa,在上述阳极层膜上真 空蒸镀化合物HI-1,形成厚度为80nm的第一空穴注入层;在第一空穴注入层之上真空蒸镀化合物HI-2,形成厚度为5nm第二空穴注入层;在第二空穴注入层之上真空蒸镀化合物HT-1,形成厚度为10nm第一空穴传输层;在第一空穴传输层上真空蒸镀化合物HT-2形成厚度为80nm第二空穴传输层;在第二空穴传输层上形成电致发光层,具体操作为:将作为发光层主体的化合物C1放置在真空气相沉积设备的单元中,将作为掺杂剂的化合物D-1放置在真空气相沉积设备的另一单元中,以不同的速率同时蒸发两种材料,D-1与主体材料化合物C1的质量比为3∶97,蒸镀总膜厚为40nm;然后将化合物ET-1和化合物EI-1分别放入真空气相沉积设备的2个单元中,以1∶1的比例进行蒸发,并且每一个沉积50Wt%的掺杂量以在发光层上形成厚度为40nm的电子传输层。接下来,将化合物EI-1作为厚度为2nm的电子注入层沉积在电子传输层上后,通过另一个真空气相沉积设备将厚度为80nm的Al阴极沉积在电子注入层上。从而形成OLED器件。使用前,在10
-6torr下通过真空升华提纯设备提纯用于制作OLED器件的所有材料。
器件实施例2-2.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物C2。
器件实施例2-3.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物C12。
器件实施例2-4.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物C25。
器件实施例2-5.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物C29。
器件实施例2-6.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物C32。
器件实施例2-7.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物C33。
器件实施例2-8.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物C36。
器件实施例2-9.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物C55。
器件实施例2-10.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物C61。
器件比较例2-1.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物CBP。
器件比较例2-2.
采用与实施例2-1相同的方法制备得到有机电致发光器件,不同在于,将主体材料化合物C1替换为化合物H-1
表5 第二优选实施方案的化合物用作主体材料时器件的测定结果
从表5中的数据可以看出,在有机电致发光器件结构中其他材料相同的情况下,器件实施例2-1~2-10与器件比较例2-1相比,差别在于,器件实施例2-1~2-10采用了本实施方案系列化合物代替器件比较例2-1中CBP作为红光主体材料。由于材料本身同时具有给电子基团和拉电子基团,使得材料具有很好的双载流子传输性能,能够有效的拓宽激子复合区域,使得三线态激子之间的淬灭显著降低,因而可以有效的提高发光效率,器件数据显示,采用本实施方案材料作为发光层主体材料能够降低器件工作电压和较高的电流效率显示了本实施方案中材料的优异的载流子传输平衡性以及能级匹配性。
与器件比较例2-1相比较,使用本实施方案的新型有机材料用于有机电致发光器件中主体材料,相对于CBP做为主体材料其电压降低了50%以上。同时具有更好的电压-电流-发光特性,更高的效率。尤其是器件的寿命较器件比较例1中的器件寿命有了非常显著提高。
与器件比较例2-2相比较,使用本实施方案的新型有机材料用于有机电致发光器件中主体材料,相对于H-1做为主体材料其电压相当或有所降低,效率和寿命也有不同程度的提高。
本申请第三优选实施方案的具体化合物的器件实施例如下:
应用以下器件结构进行OLED器件评测:ITO/HAT/HIL/HTL/EML/ETL/LiF/Al(上述缩写分别对应ITO阳极/空穴注入层/空穴传输层/发光层/电子传输层/电子注入层/LiF和Al的阴极,以下上述缩写的意义相同),下式示出了器件中各功能层所使用材料的结构式(所有材料均购自百灵威试剂,纯度>99.9%):
器件实施例3-1:使用本发明化合物作为电子传输材料
将涂布了ITO(150nm)透明导电层的玻璃板在商用清洗剂中超声处理,在去离子水中冲洗,在丙酮∶乙醇混合溶剂(体积比1∶1)中超声除油,在洁净环境下烘烤至完全除去水份,用紫外光和臭氧清洗,并用低能阳离子束轰击表面;
把上述带有阳极的玻璃基片置于真空腔内,抽真空至1×10
-5~9×10
-3pa,在上述阳极层膜上真空蒸镀HAT,形成厚度为10nm的第一空穴注入层;在第一空穴注入层之上真空蒸镀2-TNATA[4,4′,4″-三(N,N-(2-萘基)-苯基氨基)三苯胺],形成厚度为60nm的第二空穴注入层;在第二空穴注入层之上真空蒸镀化合物NPB,形成厚度为20nm的空穴传输层,蒸镀速率为0.1nm/s;
在上述空穴传输层上形成电致发光层,具体操作为:将作为发光层主体的Zn(Bzp)
2放置在真空气相沉积设备的小室中,将作为掺杂剂的(piq)
2Ir(acac)[二-(1-苯基异喹啉基)乙酰丙酮铱(III)]放置在真空气相沉积设备的另一室中,以不同的速率同时蒸发两种材料,(piq)
2Ir(acac)的浓度为4%,蒸镀总膜厚为30nm;
在发光层之上真空蒸镀本发明化合物1-121形成厚膜为20nm的电子传输层,其蒸镀速率为0.1nm/s;
在电子传输层上真空蒸镀0.5nm的LiF作为电子注入层和厚度为150nm的Al层作为器件的阴极。
器件实施例3-2.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为1-124。
器件实施例3-3.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为1-321。
器件实施例3-4.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为2-121。
器件实施例3-5.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为2-114。
器件实施例3-6.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为2-411。
器件实施例3-7.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为3-121。
器件实施例3-8.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为3-321。
器件实施例3-9.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为3-401。
器件实施例3-10.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为4-121。
器件实施例3-11.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为4-321。
器件实施例3-12.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为4-411。
器件实施例3-13.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为5B-121。
器件实施例3-14.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为5B-321。
器件实施例3-15.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为5B-401。
器件实施例3-16.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为6B-121。
器件实施例3-17.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为6B-321。
器件实施例3-18.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为6B-411。
器件实施例3-19.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为7A-121。
器件实施例3-20.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为7A-321。
器件实施例3-21.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为7A-401。
器件实施例3-22.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为8A-121。
器件实施例3-23.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为8A-321。
器件实施例3-24.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为8A-411。
器件实施例3-25.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为9A-121。
器件实施例3-26.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为9A-321。
器件实施例3-27.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为9A-401。
器件实施例3-28.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为10A-121。
器件实施例3-29.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为10A-321。
器件实施例3-30.本发明材料用作电子传输材料
采用与实施例3-1相同的方法制备得到有机电致发光器件,不同在于,将化合物1-121替换为10A-411。
器件比较例3-1.使用Bphen作为电子传输材料
采用与实施例3-1相同的方法制备有机电致发光器件,不同在于,将化合物1-121替换为Bphen。
器件比较例3-2.使用LG201:LiQ作为电子传输材料
采用与实施例3-1相同的方法制备有机电致发光器件,不同在于,将化合物1-121替换为1∶1的LG201和LiQ,采取双源共蒸的形式来实现。
在同样亮度下,使用Keithley 2602数字源表亮度计(北京师范大学光电仪器厂)测定器件实施例3-1~3-30以及对比例3-1和3-2中制备得到的有机电致发光器件的驱动电压和电流效率,结果见表6。
表6 第三优选实施方案的化合物用作电子传输材料时器件的测定结果
电子传输材料 | 要求亮度(cd/m 2) | 驱动电压(V) | 电流效率(cd/A) | |
实施例3-1 | 1-121 | 1000 | 3.5 | 12.1 |
实施例3-2 | 1-124 | 1000 | 3.4 | 12.0 |
实施例3-3 | 1-321 | 1000 | 3.6 | 12.5 |
实施例3-4 | 2-121 | 1000 | 4.0 | 12.8 |
实施例3-5 | 2-114 | 1000 | 3.6 | 12.1 |
实施例3-6 | 2-411 | 1000 | 3.7 | 12.3 |
实施例3-7 | 3-121 | 1000 | 3.6 | 12.9 |
实施例3-8 | 3-321 | 1000 | 3.6 | 12.2 |
实施例3-9 | 3-401 | 1000 | 3.7 | 12.7 |
实施例3-10 | 4-121 | 1000 | 3.6 | 11.5 |
实施例3-11 | 4-321 | 1000 | 3.6 | 12.7 |
实施例3-12 | 4-411 | 1000 | 3.4 | 12.0 |
实施例3-13 | 5B-121 | 1000 | 3.4 | 12.4 |
实施例3-14 | 5B-321 | 1000 | 3.5 | 12.8 |
实施例3-15 | 5B-401 | 1000 | 3.5 | 12.6 |
实施例3-16 | 6B-121 | 1000 | 3.6 | 12.4 |
实施例3-17 | 6B-321 | 1000 | 3.5 | 12.1 |
实施例3-18 | 6B-411 | 1000 | 3.5 | 12.3 |
实施例3-19 | 7A-121 | 1000 | 3.7 | 12.0 |
实施例3-20 | 7A-321 | 1000 | 3.8 | 12.7 |
实施例3-21 | 7A-401 | 1000 | 3.8 | 12.9 |
实施例3-22 | 8A-121 | 1000 | 3.7 | 12.3 |
实施例3-23 | 8A-321 | 1000 | 3.6 | 12.5 |
实施例3-24 | 8A-411 | 1000 | 3.8 | 12.8 |
实施例3-25 | 9A-121 | 1000 | 3.7 | 12.2 |
实施例3-26 | 9A-321 | 1000 | 3.7 | 12.4 |
实施例3-27 | 9A-401 | 1000 | 3.6 | 12.6 |
实施例3-28 | 10A-121 | 1000 | 3.7 | 12.1 |
实施例3-29 | 10A-321 | 1000 | 3.7 | 12.5 |
实施例3-30 | 10A-411 | 1000 | 3.6 | 12.7 |
对比例3-1 | Bphen | 1000 | 4.5 | 9.0 |
对比例3-2 | LG201:LiQ | 1000 | 4.1 | 10.5 |
由表6可以看出,在有机电致发光器件结构中其他材料相同的情况下,器件实施例3-1~3-30与器件比较例3-1相比,差别在于,器件实施例3-1~3-30采用了本实施方案的系列化合物代替器件比较例3-1中Bphen作为电子传输材料。本发明系列化合物由于使用更加缺电子的嘧啶(衍生物)并三氮唑(咪唑)体系,使电子注入更加有效,同时良好的电子迁移率性能更易于电子传输,可以更加有效地与空穴传输实现平衡,因而能有效的降低器件工作电压,提高电流效率,在同样的器件结构下,提高了发光器件的发光效率。
在有机电致发光器件结构中其他材料相同的情况下,器件实施例3-1~3-30与器件比较例3-2相比,差别在于,器件实施例3-1~3-30采用了本发明系列化合物代替器件比较例3-2中已商品化的电子传输材料LG201搭配LiQ作为电子传输材料,电压更低,效率也有小幅度提升。但是LG201需要用对水较敏感的LiQ搭配使用相比,本发明化合物能够在不用LiQ的情况下,有效地实现将电子从阴极注入到发光层的效果,从而减少了工艺复杂性,同时其较高的电子迁移率也有助于提升发光效率和降低工作电压。以上结果表明,本发明的新型有机材料作为有机电致发光器件的电子传输材料,是性能良好的有机发光功能材料,有望推广商业化应用。
本申请第四优选实施方案的具体化合物的器件实施例如下:
应用以下器件结构进行OLED器件评测:ITO/HAT/HIL/HTL/EML/ETL/LiF/Al(上述缩写分别对应ITO阳极/空穴注入层/空穴传输层/发光层/电子传输层/电子注入层/LiF和Al的阴极,以下上 述缩写的意义相同),下式示出了器件中各功能层所使用材料的结构式(所有材料均购自百灵威试剂,纯度>99.9%):
器件实施例4-1:使用本发明化合物作为电子传输材料
将涂布了ITO(150nm)透明导电层的玻璃板在商用清洗剂中超声处理,在去离子水中冲洗,在丙酮∶乙醇混合溶剂(体积比1∶1)中超声除油,在洁净环境下烘烤至完全除去水份,用紫外光和臭氧清洗,并用低能阳离子束轰击表面;
把上述带有阳极的玻璃基片置于真空腔内,抽真空至1×10
-5~9×10
-3Pa,在上述阳极层膜上真空蒸镀HAT,形成厚度为10nm的第一空穴注入层;在第一空穴注入层之上真空蒸镀2-TNATA[4,4′,4″-三(N,N-(2-萘基)-苯基氨基)三苯胺],形成厚度为60nm的第二空穴注入层;在第二空穴注入层之上真空蒸镀化合物NPB,形成厚度为20nm的空穴传输层,蒸镀速率为0.1nm/s;
在上述空穴传输层上形成电致发光层,具体操作为:将作为发光层主体的Zn(Bzp)
2放置在真空气相沉积设备的小室中,将作为掺杂剂的(piq)
2Ir(acac)[二-(1-苯基异喹啉基)乙酰丙酮铱(III)]放置在真空气相沉积设备的另一室中,以不同的速率同时蒸发两种材料,(piq)
2Ir(acac)的浓度为4%,蒸镀总膜厚为30nm;
在发光层之上真空蒸镀本发明化合物C2形成厚膜为20nm的电子传输层,其蒸镀速率为0.1nm/s;
在电子传输层上真空蒸镀0.5nm的LiF作为电子注入层和厚度为150nm的Al层作为器件的阴极。
器件实施例4-2.本发明材料用作电子传输材料
采用与实施例4-1相同的方法制备得到有机电致发光器件,不同在于,将化合物C2替换为C14。
器件实施例4-3.本发明材料用作电子传输材料
采用与实施例4-1相同的方法制备得到有机电致发光器件,不同在于,将化合物C2替换为C26。
器件实施例4-4.本发明材料用作电子传输材料
采用与实施例4-1相同的方法制备得到有机电致发光器件,不同在于,将化合物C2替换为C32。
器件实施例4-5.本发明材料用作电子传输材料
采用与实施例4-1相同的方法制备得到有机电致发光器件,不同在于,将化合物C2替换为C43。
器件实施例4-6.本发明材料用作电子传输材料
采用与实施例4-1相同的方法制备得到有机电致发光器件,不同在于,将化合物C2替换为C53。
器件实施例4-7.本发明材料用作电子传输材料
采用与实施例4-1相同的方法制备得到有机电致发光器件,不同在于,将化合物C2替换为C63。
器件实施例4-8.本发明材料用作电子传输材料
采用与实施例4-1相同的方法制备得到有机电致发光器件,不同在于,将化合物C2替换为C75。
器件实施例4-9.本发明材料用作电子传输材料
采用与实施例4-1相同的方法制备得到有机电致发光器件,不同在于,将化合物C2替换为C89。
器件实施例4-10.本发明材料用作电子传输材料
采用与实施例4-1相同的方法制备得到有机电致发光器件,不同在于,将化合物C2替换为C94。
器件比较例4-1.使用Bphen作为电子传输材料
采用与实施例4-1相同的方法制备有机电致发光器件,不同在于,将化合物C2替换为Bphen。
器件比较例4-2.使用LG201:QLi作为电子传输材料
采用与实施例4-1相同的方法制备有机电致发光器件,不同在于,将化合物C2替换为1∶1的LG201和QLi,采取双源共蒸的形式来实现。
在同样亮度下,使用Keithley 2602数字源表亮度计(北京师范大学光电仪器厂)测定器件实施例4-1~4-10以及对比例4-1和4-2中制备得到的有机电致发光器件的驱动电压和电流效率,结果见表7。
表7 第四优选实施方案的化合物用作电子传输材料时器件的测定结果
电子传输材料 | 要求亮度(cd/m 2) | 驱动电压(V) | 电流效率(cd/A) | |
实施例4-1 | C2 | 1000 | 3.6 | 12.9 |
实施例4-2 | C14 | 1000 | 3.8 | 12.0 |
实施例4-3 | C26 | 1000 | 3.6 | 12.3 |
实施例4-4 | C32 | 1000 | 4.0 | 11.8 |
实施例4-5 | C43 | 1000 | 3.6 | 12.2 |
实施例4-6 | C53 | 1000 | 3.7 | 12.4 |
实施例4-7 | C63 | 1000 | 3.5 | 12.1 |
实施例4-8 | C75 | 1000 | 3.7 | 11.3 |
实施例4-9 | C89 | 1000 | 3.7 | 11.0 |
实施例4-10 | C94 | 1000 | 3.6 | 10.7 |
对比例4-1 | Bphen | 1000 | 4.5 | 9.0 |
对比例4-2 | LG201:QLi | 1000 | 4.1 | 10.5 |
从表7中的数据可以看出,在有机电致发光器件结构中其他材料相同的情况下,器件实施例4-1~4-10与器件比较例4-1相比,差别在于,器件实施例4-1~4-10采用了本实施方案系列化合物代替器件比较例4-1中Bphen作为电子传输材料。本实施方案系列化合物由于使用更加缺电子的喹唑啉并三氮唑体系,使电子注入更加有效,同时良好的电子迁移率性能更易于电子传输,可以更加有效地与空穴传输实现平衡,因而能有效的降低器件工作电压,提高电流效率,在同样的器件结构下,提高了发光器件的发光效率。
器件实施例4-1~4-10与器件比较例4-2,在有机电致发光器件结构中其他材料相同的情况下,本实施方案系列化合物代替器件比较例2中已商品化的电子传输材料LG201搭配QLi作为电子传输材料,电压基本一致甚至更低,效率也有小幅度提升。但是LG201需要用对水较敏感的QLi搭配使用相比,本实施方案化合物能够在不用QLi的情况下,有效地实现将电子从阴极注入到发 光层的效果,从而减少了工艺复杂性,同时其较高的电子迁移率也有助于提升发光效率和降低工作电压。以上结果表明,本实施方案的新型有机材料作为有机电致发光器件的电子传输材料,是性能良好的有机发光功能材料,有望推广商业化应用。
以上详细描述了本发明的优选实施方式,但是,本发明并不限于上述实施方式中的具体细节,在本发明的技术构思范围内,可以对本发明的技术方案进行多种简单变型,这些简单变型均属于本发明的保护范围。
另外需要说明的是,在上述具体实施方式中所描述的各个具体技术特征,在不矛盾的情况下,可以通过任何合适的方式进行组合,为了避免不必要的重复,本发明对各种可能的组合方式不再另行说明。
此外,本发明的各种不同的实施方式之间也可以进行任意组合,只要其不违背本发明的思想,其同样应当视为本发明所公开的内容。
Claims (15)
- 一种化合物,由以下通式(I)或(II)表示:其中,X选自CR 4或N;R 1~R 4分别独立地选自氢、氘、卤素、氰基、硝基、羟基、硅烷基、取代或未取代的C1~C12的烷基、C1~C12烷氧基、取代或未取代的C3~C60的芳基或杂芳基,所述C5~C60的芳基或杂芳基的取代基选自氘、卤素、氰基、硝基、羟基、硅烷基、氨基、取代或未取代的C1~C12烷基、C1~C12烷氧基、C6~C30的取代或未取代的芳基、C10~C30的取代或未取代的杂芳基、C6~C30的取代或未取代的芳基氨基、C3~C30的取代或未取代的杂芳基氨基,所述C6~C30的取代或未取代的芳基和所述C10~C30的取代或未取代的杂芳基的取代基选自苯基、联苯基、三联苯基、萘基、菲基;R 3的数量为0~4个,当R 3的数量为2个以上时,R 3相同或者不同;L 1和L 2分别独立地选自单键、-O-、-S-、-NR a-、C1~C5的亚烷基、(C1~C3亚烷基)-O-(C1~C3亚烷基)、C6~C30的亚芳基、C3~C30的亚杂芳基;通式(II)中的虚线和Cy表示与嘧啶环稠合的五元或六元的芳环或芳杂环。
- 根据权利要求1所述的化合物,其中,R 1~R 4分别独立地选自氢、CI~C10的烷基、取代或未取代的C5~C60的芳基或杂芳基,所述芳基或杂芳基的取代基选自氘、氟、甲基、甲氧基、氰基、苯基、联苯基、萘基、菲基、吡啶基、呋喃基、噻吩基、茚基、苯并呋喃基、苯并噻吩基、取代或未取代的吲哚基、二苯并呋喃基、二苯并噻吩基、取代或未取代的咔唑基、苯并咔唑基、二苯并咔唑基,所述吲哚基和咔唑基的取代基选自苯基、联苯基、萘基、菲基,R 3的数量为1个,L 1和L 2为单键。
- 根据权利要求2所述的化合物,其中,所述通式(I)或(II)中,R 1为以下通式(III)表示的结构,:其中,L 3选自单键、-O-、-S-、C1~C5的亚烷基、(C1~C3亚烷基)-O-(C1~C3亚烷基)、C6~C30的亚芳基、C3~C30的亚杂芳基;R 5和R 6独立地选自H、D、取代或未取代的C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C10~C30的取代或未取代的杂芳基;R 5和R 6的数量分别为0~4个,当R 5或R 6的数量为2个以上时,R 5相同或者不同,R 6相同或者不同;或者R 5和R 6独立地与相连接的苯环稠合形成C9~C12的芳基或杂芳基,所形成的芳基或杂芳基任选地被0~5个独立地选自取代或未取代的C1~C12烷基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基的取代基所取代;Y为C(R 7) 2、NR 8、O、S;n为0或1,当n为0时,其表示与Y相连的两个碳原子直接相连;R 7和R 8独立地选自氢、C1~C5的烷基、苯基、卤素、氰基、硝基、羟基,两个R 7相同或者不同。
- 根据权利要求1所述的化合物,其结构由通式(II)表示,Cy为苯环,X为N,R 1由以下通式(IV)表示,R 2、R 3分别独立地选自氢、氘、C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基;其中,R 5和R 6独立地选自H、D、C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、硅烷基、氨基、C6~C30的取代或未取代的芳基氨基、C3~C30的取代或未取代的杂芳基氨基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基;R 5和R 6的数量分别为0~4个,当R 5或R 6的数量为2个以上时,R 5相同或者不同,R 6相同或者不同;或者R 5和R 6独立地与相连接的苯环稠合形成C9~C30的芳基或杂芳基,所形成的芳基或杂芳基任选地被0~5个独立地选自C1~C12烷基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基的取代基所取代;Y为C(R 7) 2、NR 8、O、S;n为0或1;当n为0时,其表示与Y 相连的两个碳原子直接相连,R 7和R 8独立地选自氢、C1~C5的烷基、苯基、卤素、氰基、硝基、羟基;两个R 7相同或者不同。
- 根据权利要求5所述的化合物,其中,所述R 5和R 6独立的选自氢、取代或未取代的C1~C4烷基、苯基、萘基、呋喃基、噻吩基、吡咯基、吡啶基、联苯基、三联苯基、萘基、蒽基、菲基、茚基、芴基及其衍生物、荧蒽基、三亚苯基、芘基、苝基、 基、并四苯基、三芳胺基、9,9-二甲基芴基、二苯乙烯基苯基、苯并芴基、茚并芴基或茚基、或者如式(V)所示二苯并杂芳基;或者R 1和R 2独立的与与之相连的苯环稠合形成萘基、蒽基、菲基、茚基、芴基、苯并呋喃基、苯并噻吩基、苯并吡啶基、苯并吡咯基,或者如式(V)所示二苯并杂芳基;其中,连接位点位于式(V)中的N上或者苯环上,当连接点位于(V)中的苯环上时,N与H、苯基、C 1~C 4的烷基相连;X’为C(R 9) 2、NR 10、O、S;m为0或1;当m为0时,其表示与X’相连的两个碳原子直接相连,R a、R b、R 9和R 10独立的选自氢、C1~C5的烷基、C1~C5烷氧基、卤素、氰基、硝基、羟基、苯基;两个R 9相同或者不同;X’与Y相同或者不同。
- 根据权利要求1所述的化合物,其中,R 1~R 4分别独立地选自氢、C1~C10的烷基、取代或未取代的C5~C60的芳基或杂芳基,所述芳基或杂芳基的取代基选自氘、氟、甲基、甲氧基、氰基、苯基、联苯基、萘基、菲基、取代或未取代的蒽基,所述蒽基的取代基选自苯基、联苯基、三联苯基、萘基、菲基,R 3的数量为1个,L 1和L 2为单键。
- 根据权利要求8所述的化合物,其中,R 1~R 4中的至少一者包含蒽环结构。
- 根据权利要求1所述的化合物,其结构由通式(II)表示,Cy为苯环,X为N,R 1、R 2、R 3分别独立地选自H、取代或未取代的C1~C12烷基、C1~C12烷氧基、卤素、氰基、硝基、羟基、硅烷基、C6~C30的取代或未取代的芳基、C3~C30的取代或未取代的杂芳基,R 3的数量为1~4个,当R 3的数量为2个以上时,R 3相同或者不同,R 1和R 2中至少一个为取代或未取代的稠合芳基,所述稠合芳基中含有2个以上的苯环形成的稠合环,或者R 1、R 2和R 3同时为苯基。
- 权利要求1~13中任一项所述的化合物在有机电致发光器件中的应用。
- 一种有机电致发光器件,该器件包括第一电极、第二电极和位于所述第一电极和第二电极之间的一层或多层有机层,其特征在于,所述有机层中包括至少一种权利要求1~9中任一项所述化合物。
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