WO2019093397A1 - 凍結乾燥生成物の製造方法、及び、凍結乾燥用袋、並びに、凍結乾燥装置 - Google Patents

凍結乾燥生成物の製造方法、及び、凍結乾燥用袋、並びに、凍結乾燥装置 Download PDF

Info

Publication number
WO2019093397A1
WO2019093397A1 PCT/JP2018/041414 JP2018041414W WO2019093397A1 WO 2019093397 A1 WO2019093397 A1 WO 2019093397A1 JP 2018041414 W JP2018041414 W JP 2018041414W WO 2019093397 A1 WO2019093397 A1 WO 2019093397A1
Authority
WO
WIPO (PCT)
Prior art keywords
bag
lyophilization
treated
freeze
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/041414
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
悟志 富田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Able Corp
Original Assignee
Able Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Able Corp filed Critical Able Corp
Publication of WO2019093397A1 publication Critical patent/WO2019093397A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/80—Freezing; Subsequent thawing; Cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Definitions

  • the present invention relates to a method of lyophilizing an object to produce a lyophilised product, a bag used for lyophilizing an object, and an apparatus for lyophilizing an object.
  • a target substance is often produced while culturing cells, microorganisms and the like in a culture solution, and usually, the target substance of the culture is obtained in a dispersed state in the culture solution.
  • Lyophilization is known as a technique for removing water from the liquid in which the target substance is dispersed, and various techniques have been proposed for the procedure, container, apparatus and the like.
  • An object of the present invention is to provide a method for producing a freeze-dried product capable of efficiently producing a freeze-dried product of stable quality, a lyophilization bag, and a freeze-drying apparatus.
  • the method for producing a freeze-dried product according to the present invention is a method for producing a freeze-dried product by freeze-drying an object to be treated, which is a bag configured to be capable of holding a liquid in a sealed state.
  • the method further comprises the steps of: supplying the solution to a bag; and lyophilizing the material to be treated, wherein the bag is at least partially constituted by a porous sheet impervious to liquid and bacteria, and the material to be treated is In the step of lyophilizing the treated material, the moisture of the material to be treated is sublimed into a gas, and the gas is discharged from the bag through the porous sheet.
  • the step of supplying the object to be treated has a desired thickness of the object based on the size information of the bag and the type information of the object to be treated. And adjusting the amount of the object to be treated.
  • the step of preparing the freeze-drying bag may include, when the object to be treated is supplied based on information on the type and amount of the object to be treated, the object to be treated.
  • the process may include the step of selecting the lyophilization bag so that the thickness of the article becomes a desired value.
  • the step of freeze-drying the object to be treated may include the step of supplying heat of sublimation to the object to be treated through the porous sheet.
  • a freeze-drying bag according to the present invention is a freeze-drying bag for freeze-drying an object to be treated contained therein, the bag body being capable of holding a liquid in a sealed state; An interior of the bag having a sterile port for aseptically supplying the object, at least a portion of the bag being constituted by a liquid- and bacteria-impermeable porous sheet The moisture of the object to be treated which has been sublimed to a gas in the lyophilization step is discharged from the bag through the porous sheet.
  • the lyophilization bag may further include a second aseptic port for aseptically supplying liquid to the inside of the bag body.
  • the aseptic port may be arranged to avoid the area constituted by the porous sheet.
  • the lyophilization apparatus according to the present invention is an apparatus for lyophilizing the pre-treated material accommodated in the lyophilization bag.
  • the lyophilizer includes a lyophilization chamber for lyophilizing the object to be treated, a pressure reducing mechanism for reducing the pressure in the lyophilization chamber, and a heating mechanism for applying sublimation heat to the object to be treated.
  • the heating mechanism may apply sublimation heat to the object via the porous sheet.
  • a lyophilization bag capable of aseptically supplying an object under general environment.
  • the freeze-drying container can be formed into a bag shape and the water can be discharged from the surface, the area of the discharge surface can be expanded, and the freeze-drying treatment can be performed efficiently.
  • a lyophilization process can be implemented on fixed conditions, and the freeze-dried product of the quality stable can be manufactured.
  • the object to be treated can be sublimated from the area close to the porous sheet, the sublimated water can be immediately discharged and the freeze-drying can be performed efficiently.
  • FIG. 1 is a view showing a freeze-drying bag according to the present embodiment.
  • FIG. 2 is a diagram showing a method of producing a lyophilized product according to the present embodiment.
  • FIG. 3 is a diagram showing a method of producing a lyophilized product according to the present embodiment.
  • FIG. 4 is a diagram showing a method of producing a lyophilized product according to the present embodiment.
  • FIG. 5 is a view showing a lyophilizer according to the present embodiment.
  • FIG. 6 is a view showing a freeze-drying bag according to a modification.
  • FIGS. 1 (A) and 1 (B) are a perspective view of the freeze-drying bag 100
  • FIG. 1 (B) is a cross-sectional view of the freeze-drying bag 100.
  • the lyophilization bag 100 is a bag used for lyophilizing the material to be treated 1 contained therein to produce a lyophilised product 2.
  • the freeze-drying bag 100 has a bag body 10.
  • the bag 10 is a member configured to be capable of holding a liquid in a sealed state therein.
  • the bag body 10 has a first surface 12 and a second surface 14 facing each other. The outer surfaces of the first and second surfaces 12 and 14 are joined to each other at opposing surfaces. This enables the bag 10 to keep the liquid sealed inside.
  • a part of the bag body (the first surface 12) is constituted by the porous sheet 16.
  • the porous sheet 16 is a sheet-like member configured to be impermeable to liquid and bacteria.
  • the porous sheet 16 is configured to allow gas to pass therethrough.
  • a non-woven fabric made by laminating a hydrophobic fibrous resin material for example, a polyolefin-based resin material
  • a sheet is DuPont Tyvek (registered trademark).
  • DuPont Tyvek registered trademark
  • the area 17 other than the porous sheet 16 of the bag body 10 is configured so as not to transmit (substantially) gas and liquid.
  • the second surface 14 can be realized, for example, by a transparent sheet of polyethylene.
  • the present invention is not limited to this, and it is also possible to constitute all the bag bodies 10 by a porous sheet (not shown).
  • the freeze-drying bag 100 has a seal portion 18 as shown in FIGS. 1 (A) and 1 (B).
  • the seal portion 18 is a region where the first and second surfaces 12 and 14 are joined.
  • the seal portion 18 is configured to surround the periphery of the bag body 10 (first and second surfaces 12 and 14). Thereby, as shown to FIG.
  • sealed space S enclosed by the 1st and 2nd surfaces 12 and 14 and the seal part 18 is formed, and in the bag 100 for lyophilization
  • the seal portion 18 can be formed, for example, by heat welding or ultrasonic welding of the first and second surfaces 12 and 14.
  • the freeze-drying bag 100 (bag body 10) is configured to be deformable, and the height of the freeze-drying bag 100 (the bag body 10) increases as the amount of the processing object 1 supplied to the space S increases. From this, in the freeze-drying bag 100, the height of the space S can be adjusted by adjusting the supply amount of the object 1 to be treated.
  • the lyophilization bag 100 has a sterile port 20, as shown in FIG. 1 (A).
  • the aseptic port 20 is a member that makes it possible to supply the object 1 aseptically to the inside of the lyophilization bag 100 (bag 10).
  • the sterile port 20 has a nozzle 22.
  • the nozzle 22 is attached to the first surface 12 of the lyophilization bag 100.
  • the aseptic port 20 has a tube 24 connected to the nozzle 22, and the aseptic connector 26 is attached to the tip of the tube 24.
  • the sterile connector 26 is a member capable of aseptically connecting the respective connection destinations even in a general environment in cooperation with the paired sterile connector 28 (see FIG. 3A). .
  • the aseptic port 20 is attached to the lyophilization bag 100 in the area 17 where the porous sheet 16 of the first surface 12 is avoided. Avoiding the porous sheet 16 can reduce the risk of outflow of the object 1 from the boundary between the aseptic port 20 and the bag 10. However, it is also possible to attach the sterile port 20 to the porous sheet 16. Further, in the present embodiment, two aseptic ports 20 are attached to the lyophilization bag 100, one for supplying the object 1 and the other for wetting the manufactured lyophilization product 2.
  • the method for producing the freeze-dried product 2 includes the step of preparing a freeze-drying bag 100 (step S10).
  • the freeze-drying bag 100 can be formed by laminating a liquid- and bacteria-impermeable porous sheet and a transparent sheet of polyethylene, and bonding the peripheral portions.
  • a method according to the purpose such as heat welding, ultrasonic welding, adhesion, etc. can be applied.
  • the lyophilization bag 100 is preferably prepared in a sterile state. After the porous sheet and the transparent sheet are joined to form a bag, irradiation with gamma rays can prepare a sterile freeze-drying bag 100.
  • the step of preparing the lyophilization bag 100 may be realized by selecting one lyophilization bag 100 from a plurality of bags of different sizes prepared in advance. At this time, the height of the space S (the thickness of the object 1 to be processed) is set to a desired value (freeze) based on the information on the processing amount in one freeze-drying bag 100 and the information on the type of the object 1 It is also possible to select the lyophilization bag 100 so as to obtain a value suitable for the drying process.
  • the manufacturing method of the lyophilization product 2 includes the step of supplying the material to be processed 1 to the space S of the lyophilization bag 100 via the aseptic port 20 (step S20).
  • step S20 the aseptic connector 26 is connected to the aseptic connector 28 and the workpiece 1 is supplied to the space S from the outside through the aseptic connectors 26 and 28. .
  • the object 1 can be supplied to the space S aseptically under a general environment without placing the lyophilization bag 100 in an aseptic environment.
  • the to-be-processed object 1 can be enclosed in the bag 100 for freeze-drying aseptically.
  • the height of the space S (the thickness of the object 1) has a desired value (lyophilization processing) based on the size information of the freeze-drying bag 100 and the type information of the object 1 It may include the step of setting the supply amount of the object 1 so as to be a suitable height).
  • the height (thickness) of the lyophilization bag 100 is determined by the amount of the material 1 to be supplied and the size of the lyophilization bag 100 (space S It depends on the circumference of From this, the material to be treated 1 is regulated to have a desired thickness (thickness suitable for the lyophilization treatment) by supplying the material to be treated 1 in a preset amount to the lyophilization bag 100. As a result, it is possible to lyophilize the object 1 efficiently.
  • the method for producing the lyophilised product 2 includes the step of producing the lyophilised product 2 by subjecting the material to be treated 1 to lyophilization (step S30). In this step, as shown in FIG.
  • the freeze-drying bag 100 is placed in a low temperature environment to freeze the object 1 and then the freeze-drying bag 100 is placed in a reduced pressure environment 4 (B) and 4 (C), the step of sublimating the water (ice) of the object to be treated 1 into a gas.
  • the sublimated gas is discharged from the space S through the porous sheet 16 of the first surface 12 (see FIG. 4 (B)). Thereby, the substance to be treated 1 is freeze-dried (water of the substance to be treated 1 is removed), and a freeze-dried product 2 is produced.
  • the step of lyophilizing the object 1 (the step of subliming the water of the object 1 into a gas) is performed via the porous sheet 16 (from the porous sheet 16 side) This can be performed while supplying sublimation heat to the object 1. As a result, the sublimated water is easily discharged from the lyophilization bag 100, so that the lyophilization process can be performed efficiently.
  • the lyophilization apparatus 200 is an apparatus for lyophilizing the object 1 to produce a lyophilised product 2.
  • the lyophilization apparatus 200 accommodates the lyophilization bag 100, and the lyophilization apparatus 200 includes the lyophilization room 202 for accommodating the lyophilization bag 100 and lyophilizing the object 1 to be processed inside. .
  • the lyophilizer 200 has a pressure reducing mechanism 204 that reduces the pressure in the lyophilization chamber 202. By decompressing the inside of the lyophilization chamber 202 by the decompression mechanism 204, the water (ice) of the to-be-treated material 1 in a frozen state is sublimated, and the gas is absorbed via the surface 12 (porous sheet) of the lyophilization bag 100. It is discharged from the space S.
  • the lyophilizer 200 has a heating mechanism 206.
  • the heating mechanism 206 is a mechanism for heating the object 1 in the lyophilization process.
  • the heating mechanism 206 can supplement the heat of sublimation to the freeze-drying bag 100 (object 1 to be treated), and the freeze-drying process can be efficiently advanced.
  • the heating mechanism 206 is configured to apply sublimation heat to the object 1 via the porous sheet 16. Further, the operation of the heating mechanism 206 is controlled such that the frozen state of the object 1 is maintained.
  • the freeze-drying bag 100 is disposed such that the porous sheet 16 (first surface 12) faces upward, and the heating mechanism 206 (heat source) is disposed above it.
  • the lyophilizer 200 has a freezing mechanism 210.
  • the freezing mechanism 210 is a mechanism for freezing (pre-freezing before drying processing) the object 1 in the lyophilization bag 100.
  • the freezing mechanism 210 is configured to lower the temperature of the lyophilization chamber 202 to freeze the object 1.
  • the present invention is not limited to this, and it is also possible to configure so as to freeze the object 1 in a freezing room different from the lyophilization room 202.
  • the lyophilizer 200 has a controller 220.
  • the controller 220 plays a role of controlling the operation of the lyophilizer 200.
  • the control unit 220 controls the operation of the pressure reducing mechanism 204 based on the set value of the air pressure of the lyophilization chamber 202 and the measured value of the air pressure of the lyophilization chamber 202 detected by the sensor 208. Thereby, the air pressure in the lyophilization chamber 202 can be maintained at the set value.
  • the control unit 220 can also be configured to control the operation of the heating mechanism 206 and the freezing mechanism 210.
  • Freezing is performed by controlling the operation of the heating mechanism 206 and the freezing mechanism 210 based on temperature data from a temperature sensor that measures the temperature of the processing object 1 and a temperature sensor that measures the temperature inside the freeze-drying chamber 202.
  • the quality and efficiency of the drying process can be enhanced.
  • the control unit 220 controls the air pressure of the lyophilization chamber 202 and the object based on the information on the size of the lyophilization bag 100, the amount of the object 1 to be supplied, and the type. It is also possible to configure to select the freezing temperature of the treatment 1. According to this, since the lyophilization process can be performed under certain conditions, the lyophilization process can be efficiently performed, and the quality of the lyophilization product 2 can be stabilized.
  • the object to be treated 1 is placed in a lyophilization bag 100 and subjected to lyophilization to produce a lyophilization product 2.
  • a part of the surface of the freeze-drying bag 100 is a porous sheet, so that the gas can be released from the surface of the freeze-drying bag 100. Therefore, the area of the gas release area can be increased, and the drying process can be performed efficiently. Further, by using the bag-like container, the distribution area of the object to be treated 1 can be widened, and the thickness of the object to be treated 1 can be reduced, so that the efficiency of the freezing process can be enhanced.
  • the lyophilization bag 100 by selecting the lyophilization bag 100 according to the amount and type of the object 1 or the amount of the object 1 according to the size of the lyophilization bag 100 and the type of the object 1.
  • the thickness of the to-be-processed object 1 can be regulated to a desired value. Since the conditions of the lyophilization between batches can be adjusted by this, the quality of a lyophilization process can be stabilized and the quality of the lyophilization product 2 can be stabilized.
  • the aseptic port 20 is connected to the lyophilization bag 100. This makes it possible to aseptically supply the object to be processed 1 to the lyophilization bag 100 even under a general environment.
  • the heat of sublimation is applied to the object 1 through the porous sheet 16. According to this, the heat of sublimation is applied to the area near the porous sheet 16 in the object 1, and the sublimation occurs from the area near the porous sheet 16. Since the sublimated gas is discharged through the porous sheet 16, the efficiency of the lyophilization process can be enhanced. And, as described above, in the present embodiment, the area of the porous sheet 16 can be increased, so that the heat of sublimation can be applied to a wide range, and the lyophilization process can be performed efficiently. Furthermore, in the present embodiment, storage and management of the lyophilized product 2 are facilitated.
  • the lyophilization process is a process for removing water from the solution
  • the volume of the object largely changes before and after the process.
  • the lyophilization process is performed in a bag-like container and the air in the container can be discharged
  • the external shape of the lyophilization bag 100 can be reduced after the lyophilization process. it can. Therefore, storage and management of the lyophilized product 2 can be facilitated without transferring the lyophilized product 2 to another container or the like. That is, according to the present embodiment, it is possible to provide a lyophilization bag 100 (storage container for the lyophilization product 2) in which the lyophilization product 2 can be easily stored and managed.
  • the lyophilization bag 101 has a first surface 32 and a second surface 34. Then, in the freeze-drying bag 101, the entire surface of the first surface 32 is formed of a porous sheet. According to this, the sublimated gas can be discharged from the entire surface of the first surface 32. This can further increase the efficiency of the lyophilization process.
  • seat of 2 sheets was mentioned as an example and demonstrated as a lyophilization bag so far, this invention is not limited to this. Although not particularly illustrated, it is also possible to use a three-dimensional bag (three-dimensionally constructed bag) having a gusset as a freeze-drying bag.
  • a freeze-dried product with stable quality by regulating the outer shape of the object to be treated so that the thickness of the object becomes a desired value based on the size information of the bag and the type information of the object to be treated In the field where technology for producing the target substance is spreading while cultivating cells, microorganisms etc. in culture solution using cells It can be applied mainly to the field of food.

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Food Science & Technology (AREA)
  • Mechanical Engineering (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
  • Packages (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
PCT/JP2018/041414 2017-11-10 2018-11-01 凍結乾燥生成物の製造方法、及び、凍結乾燥用袋、並びに、凍結乾燥装置 Ceased WO2019093397A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017-229632 2017-11-10
JP2017229632A JP2019090596A (ja) 2017-11-10 2017-11-10 凍結乾燥生成物の製造方法、及び、凍結乾燥用袋、並びに、凍結乾燥装置

Publications (1)

Publication Number Publication Date
WO2019093397A1 true WO2019093397A1 (ja) 2019-05-16

Family

ID=66438926

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2018/041414 Ceased WO2019093397A1 (ja) 2017-11-10 2018-11-01 凍結乾燥生成物の製造方法、及び、凍結乾燥用袋、並びに、凍結乾燥装置

Country Status (2)

Country Link
JP (1) JP2019090596A (enExample)
WO (1) WO2019093397A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11175092B2 (en) * 2016-10-10 2021-11-16 Purdue Research Foundation Continuous roll-to-roll freeze-drying system and process
EP4553432A1 (en) * 2023-11-08 2025-05-14 Bachem Holding AG Drying bag and drying system
WO2025099273A1 (en) * 2023-11-08 2025-05-15 Bachem Holding Ag Drying bag and drying system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0229256A (ja) * 1988-05-26 1990-01-31 Boehringer Mannheim Gmbh 生物学的または薬学的物質を凍結乾燥する容器
US6517526B1 (en) * 2000-12-29 2003-02-11 Yehuda Tamari Container for lyophilizing biological products
US20140259724A1 (en) * 2013-03-13 2014-09-18 Hemcon Medical Technologies, Inc. Low Aspect Ratio Staged Closure Devices, Systems, and Methods for Freeze-Drying, Storing, Reconstituting, and Administering Lyophilized Plasma

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07121354B2 (ja) * 1986-07-30 1995-12-25 東海高熱工業株式会社 粒状乾燥物製造方法及び真空凍結乾燥装置
CN102226635B (zh) * 2011-06-09 2013-02-27 四川宏普微波科技有限公司 一种微波连续冻干装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0229256A (ja) * 1988-05-26 1990-01-31 Boehringer Mannheim Gmbh 生物学的または薬学的物質を凍結乾燥する容器
US6517526B1 (en) * 2000-12-29 2003-02-11 Yehuda Tamari Container for lyophilizing biological products
US20140259724A1 (en) * 2013-03-13 2014-09-18 Hemcon Medical Technologies, Inc. Low Aspect Ratio Staged Closure Devices, Systems, and Methods for Freeze-Drying, Storing, Reconstituting, and Administering Lyophilized Plasma

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11175092B2 (en) * 2016-10-10 2021-11-16 Purdue Research Foundation Continuous roll-to-roll freeze-drying system and process
US20220074662A1 (en) * 2016-10-10 2022-03-10 Purdue Research Foundation Continuous roll-to-roll freeze-drying system and process
US11592236B2 (en) * 2016-10-10 2023-02-28 Purdue Research Foundation Continuous roll-to-roll freeze-drying system and process
EP4553432A1 (en) * 2023-11-08 2025-05-14 Bachem Holding AG Drying bag and drying system
WO2025098660A1 (en) * 2023-11-08 2025-05-15 Bachem Holding Ag Drying bag and drying system
WO2025099273A1 (en) * 2023-11-08 2025-05-15 Bachem Holding Ag Drying bag and drying system

Also Published As

Publication number Publication date
JP2019090596A (ja) 2019-06-13

Similar Documents

Publication Publication Date Title
JP7649274B2 (ja) 凍結乾燥
WO2019093397A1 (ja) 凍結乾燥生成物の製造方法、及び、凍結乾燥用袋、並びに、凍結乾燥装置
EP3694322B1 (en) Lyophilization container and method of using same
US6447701B1 (en) Method for producing porous structures
JP5411256B2 (ja) 細胞培養装置および方法
JP6598477B2 (ja) 複合材の成形装置及び複合材の成形方法
JPS5832085B2 (ja) シンクウスキンホウソウホウホウ オヨビ ソノタメノソウチ
JP2019090596A5 (enExample)
KR101806344B1 (ko) 폴리감마글루탐산의 최적 진공동결건조 방법
TWI351505B (en) An effective method to improve the drying rate of
WO2015162273A1 (en) A method to dry multiple individual frozen bodies and a system for applying this method
TWM542140U (zh) 與冷凍乾燥機配合使用的艙體
Babu et al. 6. Recent Advances in Freeze-Drying: A Comprehensive Review of Principles, Innovations and Applications
JP3892530B2 (ja) 木質材の寸法安定化処理方法
HK40070219A (en) Multi-part lyophilization container and method of use
JPH1110608A (ja) 木質材の寸法安定化方法
TW201112971A (en) Method of improve the drying rate of freeze-drying

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18875888

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18875888

Country of ref document: EP

Kind code of ref document: A1