Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
  • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
  • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
  • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents

Definitions

• the present invention relates to solvents for agricultural applications (e.g., pesticides) and to pesticide formulations.
• High polarity solvents play a critical role in the preparation of pesticide formulations by dissolving active ingredients to make high concentration products.
• Commonly used high polarity solvents include, for example, N-methyl pyrrolidone (NMP) or dimethyl sulfoxide (DMSO) , which provide excellent dissolution performance with various active ingredients.
• NMP N-methyl pyrrolidone
• DMSO dimethyl sulfoxide
• reproductive toxicity or other toxicity which drive global safety and regulatory concerns.
• the present invention provides solvents for agricultural applications, such as pesticides, that, in some embodiments, have good dissolution properties for a variety of active ingredients.
• the present invention provides a solvent for pesticides that comprises (a) an ether ester of Formula 1:
• R 1 and R 2 are each independently one of an alkyl group having 1 to 4 carbon atoms or an aryl group, wherein R 3 is hydrogen, methyl, or ethyl, and wherein n is 1 to 6; and (b) a polar amide of Formula 2:
• R 4 is an alkyl group having 1 to 4 carbon atoms
• R 5 and R 6 are each independently an alkyl group having 1 to 3 carbon atoms.
• the present invention provides a solvent for pesticides that consists essentially of (a) an ether ester of Formula 1:
• R 1 and R 2 are each independently one of an alkyl group having 1 to 4 carbon atoms or an aryl group, wherein R 3 is hydrogen, methyl, or ethyl, and wherein n is 1 to 6; and (b) a polar amide of Formula 2:
• R 4 is an alkyl group having 1 to 4 carbon atoms
• R 5 and R 6 are each independently an alkyl group having 1 to 3 carbon atoms.
• the present invention provides a pesticide formulation that comprises a solvent according to any of the embodiments of the present invention disclosed herein and a pesticide.
• the present invention provides a pesticide formulation that comprises (a) 5 to 30 weight percent of the ether ester of Formula 1; (b) 30 to 90 weight percent of the polar amide of Formula 2; (c) 2 to 70 weight percent of a pesticide; and (d) 3 to 20 weight percent of an emulsifier.
• an aqueous composition that includes particles of “a” hydrophobic polymer can be interpreted to mean that the composition includes particles of "one or more" hydrophobic polymers.
• the numerical ranges disclosed herein include all values from, and including, the lower and upper value.
• ranges containing explicit values e.g., 1 to 7
• any subrange between any two explicit values is included (e.g., 1 to 2; 2 to 6; 5 to 7; 3 to 7; 5 to 6; etc. ) .
• compositions claimed through use of the term “comprising” may include any additional additive, adjuvant, or compound, whether polymeric or otherwise, unless stated to the contrary.
• the term, “consisting essentially of” excludes from the scope of any succeeding recitation any other component, step, or procedure, excepting those that are not essential to operability.
• the term “consisting of” excludes any component, step, or procedure not specifically delineated or listed.
• solvent and like terms mean a substance that is capable of dissolving another substance (i.e., a solute) to form an essentially uniformly dispersed mixture (i.e., solution) at the molecular or ionic size level.
• a solvent for pesticides comprises (a) an ether ester of Formula 1:
• R 1 and R 2 are each independently one of an alkyl group having 1 to 4 carbon atoms or an aryl group, wherein R 3 is hydrogen, methyl, or ethyl, and wherein n is 1 to 6; and (b) a polar amide of Formula 2:
• R 4 is an alkyl group having 1 to 4 carbon atoms, and wherein R 5 and R 6 are each independently an alkyl group having 1 to 3 carbon atoms.
• R 4 of the polar amide of Formula 2 is a methyl group or an ethyl group.
• the polar amide in some embodiments, is N, N-diethyl acetamide or N, N-dimethyl propanamide.
• R 1 and R 2 of the ether ester of Formula 1 are ethyl groups, R 3 is hydrogen, and n is 2.
• the solvent in some embodiments, comprises up to 20 weight percent of the ether ester based on the total weight of the solvent.
• a solvent for pesticides consists essentially of (a) an ether ester of Formula 1:
• R 1 and R 2 are each independently one of an alkyl group having 1 to 4 carbon atoms or an aryl group, wherein R 3 is hydrogen, methyl, or ethyl, and wherein n is 1 to 6; and (b) a polar amide of Formula 2:
• R 4 is an alkyl group having 1 to 4 carbon atoms, and wherein R 5 and R 6 are each independently an alkyl group having 1 to 3 carbon atoms.
• R 4 of the polar amide of Formula 2 is a methyl group or an ethyl group.
• the polar amide in some embodiments, is N, N-diethyl acetamide or N, N-dimethyl propanamide.
• R 1 and R 2 of the ether ester of Formula 1 are ethyl groups, R 3 is hydrogen, and n is 2.
• the solvent in some embodiments, comprises up to 20 weight percent of the ether ester based on the total weight of the solvent.
• a pesticide formulation comprises a solvent according to any of the embodiments of the present invention disclosed herein and a pesticide.
• the pesticide comprises one or more of abamectin, tebuconazole, difenoconazole, triazolone, quizalofop-p-ethyl, myclobutanil, diafenthiuron, pyraclostrobin, bifenthrin, buprofezin, and beta-cypermethrin.
• the pesticide formulation further comprises an emulsifier.
• a pesticide formulation in some embodiments, comprises (a) 5 to 30 weight percent of the ether ester of Formula 1; (b) 30 to 90 weight percent of the polar amide of Formula 2; (c) 2 to 70 weight percent of a pesticide; and (d) 3 to 20 weight percent of an emulsifier.
• Solvents for pesticides comprise (a) an ether ester of Formula 1:
• R 1 and R 2 are each independently one of an alkyl group having 1 to 4 carbon atoms or an aryl group, wherein R 3 is hydrogen, methyl, or ethyl, and wherein n is 1 to 6; and (b) a polar amide of Formula 2:
• R 4 is an alkyl group having 1 to 4 carbon atoms
• R 5 and R 6 are each independently an alkyl group having 1 to 3 carbon atoms.
• the first component of solvents for pesticides of the present invention consists of, or is, an ether ester of Formula 1:
• R 1 and R 2 are each independently one of an alkyl group having 1 to 4 carbon atoms or an aryl group, wherein R 3 is hydrogen, methyl, or ethyl, and wherein n is 1 to 6. In some embodiments, R 1 and R 2 are ethyl groups, R 3 is hydrogen, and n is 2.
• the ether ester is ethyl-3-ethoxy propionate and is commercially available from The Dow Chemical Company as UCAR TM Ester EEP.
• solvents of the present invention comprise or consist essentially of up to 25 weight percent of the ether ester. Solvents of the present invention, in other embodiments, comprise or consist essentially of up to 20 weight percent of the ether ester. In some embodiments, solvents of the present invention comprise or consist essentially of 15 to 20 weight percent of the ether ester.
• the second component of solvents for pesticides of the present invention consists of, or is, a polar amide of Formula 2:
• R 4 is an alkyl group having 1 to 4 carbon atoms, and wherein R 5 and R 6 are each independently an alkyl group having 1 to 3 carbon atoms.
• R 4 of the polar amide of Formula 2 is a methyl group or an ethyl group.
• the polar amide in some embodiments, is N, N-diethyl acetamide (CAS Number 685-91-6) or N, N-dimethyl propanamide (CAS Number 758-96-3) . In some embodiments, the polar amide is N, N-dimethyl propanamide.
• solvents of the present invention comprise or consist essentially of up to 90 weight percent of the polar amide.
• Solvents of the present invention in other embodiments, comprise or consist essentially of 60 to 90 weight percent of the polar amide. In some embodiments, solvents of the present invention comprise or consist essentially of 70 to 85 weight percent of the polar amide.
• Solvents of the present invention are made using known equipment and known techniques.
• the individual components of the solvent are commercially available, liquid at ambient conditions (23°C and atmospheric pressure) , and can simply be mixed with one another using conventional mixing equipment and standard blending protocols.
• the components can be added to one another in any order including simultaneously.
• the solvent for pesticides is a blend consisting of, or consisting essentially of, the ether ester of Formula 1 (as described above) as the first component and the polar amide of Formula 2 (as described above) as the second component.
• the solvent for pesticides is a blend consisting of, or consisting essentially of, ethyl-3-ethoxy propionate and the polar amide of Formula 2 (as described above) .
• the solvent for pesticides is a blend consisting of, or consisting essentially of, the ether ester of Formula 1 (as described above) as the first component and N, N-diethyl acetamide as the second component.
• the solvent for pesticides is a blend consisting of, or consisting essentially of, the ether ester of Formula 1 (as described above) as the first component and N, N-dimethyl propanamide as the second component.
• the solvent for pesticides is a blend consisting of, or consisting essentially of, ethyl-3-ethoxy propionate and N, N-diethyl acetamide.
• the solvent for pesticides is a blend consisting of, or consisting essentially of, ethyl-3-ethoxy propionate and N, N-dimethyl propanamide as the second component.
• solvents of the present invention are useful in forming pesticide formulations of the present invention.
• Pesticide formulations according to the present invention comprise a pesticide and a solvent according to any of the embodiments of solvents for pesticides disclosed herein. These pesticides include, but are not limited to, one or more of abamectin, tebuconazole, difenoconazole, triazolone, quizalofop-p-ethyl, myclobutanil, diafenthiuron, pyraclostrobin, bifenthrin, buprofezin, and beta-cypermethrin.
• the pesticide formulation further comprises an emulsifier.
• emulsifiers that can be used in embodiments of pesticide formulations of the present invention include, for example, TERGITOL TM 15-S-9, DOWFAX TM D-800, , DOWFAX TM 2A1, and TRITON TM GR-7M, each of which are available from The Dow Chemical Company.
• a pesticide formulation of the present invention comprises 5 to 30 weight percent of the ether ester of Formula 1 (as described above) , 30 to 90 weight percent of the polar amide of Formula 2 (as described above) , 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 5 to 30 weight percent of ethyl-3-ethoxy propionate, 30 to 90 weight percent of the polar amide of Formula 2 (as described above) , 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 5 to 30 weight percent of the ether ester of Formula 1 (as described above) , 30 to 90 weight percent of N, N-diethyl acetamide, 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 5 to 30 weight percent of the ether ester of Formula 1 (as described above) , 30 to 90 weight percent of N, N-dimethyl propanamide, 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 5 to 30 weight percent of ethyl-3-ethoxy propionate, 30 to 90 weight percent of N, N-diethyl acetamide, 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 5 to 30 weight percent of ethyl-3-ethoxy propionate, 30 to 90 weight percent of N, N-dimethyl propanamide, 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 5 to 30 weight percent of the ether ester of Formula 1 (as described above) , 30 to 90 weight percent of the polar amide of Formula 2 (as described above) , 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 5 to 30 weight percent of ethyl-3-ethoxy propionate, 30 to 90 weight percent of the polar amide of Formula 2 (as described above) , 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 5 to 30 weight percent of the ether ester of Formula 1 (as described above) , 30 to 90 weight percent of N, N-diethyl acetamide, 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 5 to 30 weight percent of the ether ester of Formula 1 (as described above) , 30 to 90 weight percent of N, N-dimethyl propanamide, 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 5 to 30 weight percent of ethyl-3-ethoxy propionate, 30 to 90 weight percent of N, N-diethyl acetamide, 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 5 to 30 weight percent of ethyl-3-ethoxy propionate, 30 to 90 weight percent of N, N-dimethyl propanamide, 2 to 70 weight percent of one or more pesticides, and 3 to 20 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 10 to 25 weight percent of the ether ester of Formula 1 (as described above) , 40 to 85 weight percent of the polar amide of Formula 2 (as described above) , 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 10 to 25 weight percent of ethyl-3-ethoxy propionate 40 to 85 weight percent of the polar amide of Formula 2 (as described above) , 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 10 to 25 weight percent of the ether ester of Formula 1 (as described above) , 40 to 85 weight percent of N, N-diethyl acetamide, 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 10 to 25 weight percent of the ether ester of Formula 1 (as described above) , 40 to 85 weight percent of N, N-dimethyl propanamide, 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 10 to 25 weight percent of ethyl-3-ethoxy propionate, 40 to 85 weight percent of N, N-diethyl acetamide, 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention comprises 10 to 25 weight percent of ethyl-3-ethoxy propionate, 40 to 85 weight percent of N, N-dimethyl propanamide, 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 10 to 25 weight percent of the ether ester of Formula 1 (as described above) , 40 to 85 weight percent of the polar amide of Formula 2 (as described above) , 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 10 to 25 weight percent of ethyl-3-ethoxy propionate, 40 to 85 weight percent of the polar amide of Formula 2 (as described above) , 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 10 to 25 weight percent of the ether ester of Formula 1 (as described above) , 40 to 85 weight percent of N, N-diethyl acetamide, 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 10 to 25 weight percent of the ether ester of Formula 1 (as described above) , 40 to 85 weight percent of N, N-dimethyl propanamide, 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 10 to 25 weight percent of ethyl-3-ethoxy propionate, 40 to 85 weight percent of N, N-diethyl acetamide, 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• a pesticide formulation of the present invention consists of, or consists essentially of, 10 to 25 weight percent of ethyl-3-ethoxy propionate, 40 to 85 weight percent of N, N-dimethyl propanamide, 5 to 40 weight percent of one or more pesticides, and 5 to 15 weight percent of an emulsifier, each based on the total weight of the pesticide formulation.
• Optional materials that are not essential to the operability of, but can be included in, the pesticide formulations of this invention include, but are not limited to, antioxidants, colorants, water scavengers, stabilizers, and the like. These materials do not have any material impact on the efficacy of the pesticide formulation. These optional materials are used in known amounts, e.g., 0.10 to 5, or 4, or 3, or 2, or 1, weight percent based on the weight of the solvent, and they are used in known ways.
• Pesticide formulations can be prepared using techniques known to those of skill in the art. For example, the active ingredient (pesticide) can be dissolved in a solvent, and then emulsifiers or other conventional additives can be added.
• the ethyl 3-ethoxypropionate is UCAR TM Ester EEP available from The Dow Chemical Company.
• the DMSO is from Sinopharm, Co.
• DMAA810 is from Wilmar International Limited.
• the DEAC, DMPA, and DMSO are commercial grade solvents that are commercially available from a variety of suppliers.
• Each pesticide powder is added by solvent in 2%stepwise increments to the final pesticide concentration.
• Each pesticide reaches a concentration where the pesticide powder is not dissolved by the solvent.
• the concentration just prior to the concentration where the pesticide powder is not dissolved is shown in Table 3.
• the data in Table 3 reflects a solubility that is no more than 2%lower than the actual solubility.
• DEAC and DMPA exhibit stronger dissolving power than comparative solvents DMSO and DMAA810, not just for one active ingredient, but for each of the active ingredients evaluated.
• DEAC and DMPA are each polar amides that fall within Formula 2 (as described above) and are thus potential components of solvents for pesticides according to embodiments of the present invention.
• a number of pesticide formulations are prepared and evaluated for their dissolving performance and stability.
• the active ingredient is an amide-based pesticide.
• the following pesticide formulations are prepared as emulsifiable concentrates, each having ⁇ 6 weight percent of the active ingredient.
• Emulsifier 1 is TERGITOL TM 15-S-9, which is commercially available from The Dow Chemical Company.
• Emulsifier 2 is TRITON TM GR-7M, which is commercially available from The Dow Chemical Company.
• Comparative Example 1 utilizing DMSO provides excellent dissolving performance of the active ingredient, but exhibits poor stability upon dilution and poor cold storage stability.
• the active ingredient is not dissolved in a solvent mixture of DMSO with the Ether Ester.
• the pesticide formulations provide excellent dissolvability of the active ingredient, stability upon dilution, cold storage stability and thermal storage stability.
• the solvents used in the Inventive Examples thus dissolve active ingredients at a high concentration while providing excellent stability and a better environmental profile relative to DMSO.

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• Life Sciences & Earth Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Health & Medical Sciences (AREA)
• Toxicology (AREA)
• Pest Control & Pesticides (AREA)
• Plant Pathology (AREA)
• Agronomy & Crop Science (AREA)
• Engineering & Computer Science (AREA)
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• Dispersion Chemistry (AREA)
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• 2017
  • 2017-11-03 ES ES17930714T patent/ES2969257T3/es active Active
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