WO2019061679A1 - Dispositif de pressage de médicament stéréoscopique et son procédé d'utilisation - Google Patents

Dispositif de pressage de médicament stéréoscopique et son procédé d'utilisation Download PDF

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Publication number
WO2019061679A1
WO2019061679A1 PCT/CN2017/109475 CN2017109475W WO2019061679A1 WO 2019061679 A1 WO2019061679 A1 WO 2019061679A1 CN 2017109475 W CN2017109475 W CN 2017109475W WO 2019061679 A1 WO2019061679 A1 WO 2019061679A1
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WIPO (PCT)
Prior art keywords
grinding
pressing
press
support cylinder
pair
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PCT/CN2017/109475
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English (en)
Chinese (zh)
Inventor
杨松
田洪亮
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杨松
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Publication of WO2019061679A1 publication Critical patent/WO2019061679A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0007—Pill breaking or crushing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00—Other disintegrating devices or methods
    • B02C19/08—Pestle and mortar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/20—Extrusion means, e.g. for producing pharmaceutical forms

Definitions

  • the invention relates to the field of medical auxiliary equipment, in particular to a stereo drug press and a using method thereof.
  • Tablet medicine is a common oral medicine in the medical field.
  • the so-called tablet is a wafer-shaped or hetero-shaped preparation which is processed by a specific molding process after the medicine and the auxiliary material are uniformly mixed, and has the advantages of accurate dosage, convenient carrying and transportation.
  • abrasive devices usually use a shock, hammer, etc. to smash the tablets. This method usually exerts a large force, which increases the burden on medical personnel and brings noise, which is not suitable for a quiet medical environment.
  • Another type of grinding device uses a lever structure to crush a tablet, and places the tablet in the splint. The force is applied by the hand piece. The grinding device using the lever structure cannot uniformly apply force during operation, and is easily applied by an excessive moment. Causing a stuck phenomenon can also cause unnecessary noise.
  • the rotary abrasive device is more suitable for a quiet medical environment, but the existing rotary abrasive device is used to grind the tablet by a simple rotary pressing force, usually because the tablet is hard during the application of the force. It is difficult to smash and other characteristics, and it has to be re-ground and re-grind, which makes the operation time-consuming and laborious; it needs to be cleaned in time when grinding different tablets, and it is impossible to carry out the grinding operation efficiently and continuously. Improper cleaning can also cause cross-contamination of tablets. problem.
  • the object of the present invention is to provide a stereo drug press and a method of using the same, which overcomes the difficulties in the prior art, makes the pressing process time-saving and labor-saving, and can adjust the thickness of the powder.
  • a stereo drug press comprising:
  • the pressure grinding cover at least includes an annular side wall, a partitioning platform is disposed in the annular side wall, and a first surface of the partitioning platform forms a first pressing surface;
  • a pressure grinding support cylinder comprising at least a support platform, a cylindrical boss protruding from the support platform toward the first side, and an annular outer wall surrounding the cylindrical boss; the cylindrical boss Forming a second pressing surface on the end surface, the second pressing surface and the annular outer wall forming a pressing space;
  • An annular side wall of the pressure grinding cover enters the grinding space from a first side of the pressure grinding support cylinder, and the first pressing surface cooperates with the second pressing surface to form a first pair of pressing surfaces a clearance between an inner wall of the annular side wall of the pressure grinding cover and a side wall of the cylindrical boss of the pressure grinding support cylinder to form a second pair of pressing surfaces, the first pair of pressing surfaces and the The second pair of pressing surfaces are connected.
  • the support platform between the outer circumference of the cylindrical boss and the annular outer wall is provided with a plurality of powder leakage holes.
  • the second grinding surface further comprises a plurality of powder leakage holes.
  • the distribution density of the powder leakage holes gradually increases as the second grinding surface is from the center to the periphery.
  • the first pressing surface is provided with a plurality of protruding first grinding teeth
  • the second pressing surface is provided with a plurality of protruding second grinding teeth, the first grinding tooth and the second grinding tooth
  • the annular side wall of the pressure grinding cover is provided with a first loose fit wide pitch thread
  • the annular outer wall of the pressure grinding support cylinder is provided with a second loose fit wide pitch thread
  • the first loose fit wide pitch thread Abutting the second loose-fit wide-pitch thread
  • the thread groove widths of the first loose-fit wide-width thread and the second loose-fit wide-width thread are greater than or equal to a sum of the thread width and the rhythm amplitude.
  • the press cover includes a first annular sidewall and a second annular sidewall, the first frosted surface is formed within the second annular sidewall, and the second annular sidewall surrounds Outside the first annular side wall, the inner wall of the second annular side wall is provided with a first loose fit wide pitch thread; the outer wall of the annular outer wall of the pressure grinding support cylinder is provided with a second loose fit wide pitch thread.
  • the first annular side wall of the pressure grinding cover is inserted between the annular outer wall of the pressure grinding support cylinder and the cylindrical boss, and the inner wall of the second annular side wall is screwed to the outer wall of the annular outer wall.
  • the outer circumference of the pressure grinding support cylinder is further provided with an outer shoulder, and the second annular side wall abuts the outer shoulder.
  • the pressure grinding cover comprises a first annular side wall, the outer wall of the first annular side wall is provided with a first loose fit wide pitch thread; the inner wall of the annular outer wall of the pressure grinding support cylinder is provided with a second Loosely fitting a wide pitch thread, the outer wall of the first annular side wall being screwed to the inner wall of the annular outer wall.
  • the first grinding tooth and the second grinding tooth are alternately alternated between staggered engagement and abutment to form a rhythmic fit.
  • the height of the first grinding tooth protruding from the first pressing surface ranges from 0.1 mm to 10 mm; the height of the second grinding tooth protruding from the second pressing surface is 0.1 Mm to 10 mm; the thread width of the first loose fit wide pitch thread and the second loose fit wide pitch thread are in the range of 0.1 to 10 mm; the first loose fit wide pitch thread and the second loose fit wide pitch thread
  • the thread groove width ranges from 0.2 to 20 mm.
  • the first grinding tooth comprises a plurality of radially linear first protrusions centered on a central axis of the embossing cover, the second grinding teeth comprising a center axis of the cylindrical boss And a plurality of radially extending second protrusions, wherein the size and the gap of the first protrusion are equal to the size and the gap of the second protrusion.
  • the first grinding tooth comprises a plurality of radial curved third protrusions centered on a central axis of the embossing cover, the second grinding tooth comprising a center of the cylindrical boss
  • the plurality of radial protrusions run toward the fourth protrusions, and the size and the gap of the third protrusions are equal to the size and the gap of the fourth protrusions.
  • the first pressing surface is recessed from the periphery toward the center to form a conical recess
  • the second pressing surface protrudes from the periphery toward the center to form a conical structure
  • the conical recess of the first grinding surface The taper angle is equal to a taper angle of the conical structure of the second press surface, and the first pair of press faces is a conical surface.
  • the first pressing surface is recessed from the periphery toward the center to form a hemispherical dimple, and the second pressing surface is from the periphery.
  • a hemispherical projection is formed toward the central protrusion, and the first pair of pressing surfaces is a hemispherical surface.
  • the inner wall of the annular side wall of the pressure grinding cover is provided with a third grinding tooth
  • the side wall of the cylindrical boss of the pressure grinding support cylinder is provided with a fourth grinding tooth
  • the third grinding tooth and the The fourth grinding teeth are alternately matched
  • the second pair of pressing surfaces are round tube type pressing surfaces.
  • a tray is further included, the cup being screwed to the second side of the press-fit support cylinder.
  • the cup is combined with the second side of the press-supporting support cylinder to form a storage bin.
  • a method of using a stereo drug applicator for grinding a tablet comprising: a vertical rapid grinding state or a tilting fine grinding state based on the above-described stereo drug injector Any of them;
  • the vertical rapid grinding state includes: placing a tablet, inserting the pressing cover into the pressure-receiving support cylinder, maintaining a central axis of the pressure-receiving support cylinder in a gravity direction, and pressing the press-grinding cover toward the press-grinding support
  • the cylinder is spun, and the powder after the tablet is ground is ground by the first pair of pressing surfaces, and then guided to the second pair of pressing surfaces to continue grinding and gradually falling under the action of gravity;
  • the tilting fine grinding state includes: inserting a tablet, inserting the press grinding cap into the press-fitting support cylinder, tilting a center axis of the press-grinding support cylinder to a gravity direction, and pressing the press-grinding cover toward the press grinding
  • the support cylinder is spun, and the powder after the tablet is ground is ground by the first pair of pressing surfaces and guided to the second pair of pressing surfaces to continue grinding.
  • the time during which the powder of the tablet passes through the second pair of press faces in the oblique fine grinding state is greater than the time when the powder of the tablet passes through the second pair of press faces in the vertical rapid grinding state.
  • the longer the powder passes through the second pair of pressing surfaces the smaller the particle diameter of the powder.
  • the fineness of the powder, the powder particles must be less than or equal to this gap to pass and fall.
  • a method of using a stereo drug applicator for grinding a tablet comprising: a vertical rapid grinding state or a tilting fine grinding state based on the above-described stereo drug injector Any of them;
  • the vertical rapid grinding state includes: placing a tablet, inserting the pressing cover into the pressure-receiving support cylinder, maintaining a central axis of the pressure-receiving support cylinder in a gravity direction, and pressing the press-grinding cover toward the press-grinding support
  • the cylinder is spun, and the powder after the tablet is ground is ground by the first pair of pressing surfaces and guided to the second pair of pressing surfaces to continue grinding;
  • the tilting fine grinding state includes: inserting a tablet, inserting the press grinding cap into the press-fitting support cylinder, tilting a center axis of the press-grinding support cylinder to a gravity direction, and pressing the press-grinding cover toward the press grinding Spinning of the support cylinder, after the tablets are ground
  • the powder is ground by the first pair of pressing surfaces and guided to the second pair of pressing surfaces to continue grinding and gradually falling under the action of gravity;
  • the time during which the powder of the tablet passes through the second pair of pressing faces in the oblique fine grinding state is greater than the time when the powder of the tablet passes through the second pair of pressing faces in the vertical rapid grinding state;
  • the second annular sidewall is repeatedly crimped as the first grinding tooth and the second grinding tooth are alternately alternated between the staggered engagement and the abutment.
  • the shoulder or the outer shoulder forms an inhalation effect, guiding the air into the pressing space, and blowing the powder on the surface of the first pressing surface and the surface of the second pressing surface.
  • the three-dimensional pressure applicator of the present invention and the method of using the same make the pressing process time-saving and labor-saving, and can adjust the thickness of the powder to meet the oral or nasal feeding (requires the syringe to extract the dissolved powder into the nasal feeding tube, so The powder needs to be ground more carefully) for patients with different thicknesses of powder.
  • the invention has the following advantages:
  • the three-dimensional applicator of the present invention can control the time during which the powder of the tablet passes through the pressing surface by the cooperation of the two-stage first pressing surface and the second pressing surface, and the inclination angle is larger. The longer the powder passes through the second pressing surface, the finer the powder is ground.
  • the screwing position of the first loose-fit wide-width thread and the second loose-fit wide-width thread in the present invention is outside the pressing space, and the first loose-fit wide-width thread and the second loose-fit wide-width thread can be prevented.
  • the threaded worn powder falls into the crushed powder.
  • Figure 1 is a perspective view of a three-dimensional applicator of the present invention
  • Figure 2 is a cross-sectional view of the three-dimensional applicator of the present invention.
  • Figure 3 is an exploded view of the three-dimensional applicator of the present invention.
  • Figure 4 is a cross-sectional view showing the exploded state of the three-dimensional applicator of the present invention.
  • Figure 5 is a plan view of the press-supporting support cylinder of the present invention.
  • Figure 6 is a schematic view showing the direction of the powder of the three-dimensional pressure applicator of the present invention.
  • FIG. 7 to 11 are schematic views showing the flow of use of the three-dimensional pressure applicator of the present invention.
  • Figure 12 is a schematic view showing a tilted fine grinding state of the three-dimensional applicator of the present invention.
  • Figure 13 is a schematic view showing another oblique fine grinding state of the three-dimensional applicator of the present invention.
  • Figure 14 is a perspective view of another three-dimensional applicator of the present invention.
  • Figure 15 is a cross-sectional view of the stereo drug press of Figure 14;
  • Figure 16 is a cross-sectional view showing the exploded state of the three-dimensional applicator of Figure 14;
  • Figure 17 is a cross-sectional view of the stereo drug press of Figure 14;
  • Figure 18 is a plan view of the pressure grinding support cylinder of Figure 14;
  • Figure 19 is a partial enlarged view of Figure 17;
  • Figure 20 is a schematic view of the threaded engagement of the spinning state of the present invention.
  • Figure 21 is a schematic view of the threaded engagement of the grinding state of the present invention.
  • Figure 22 is a cross-sectional view showing another three-dimensional applicator of the present invention.
  • Figure 23 is a cross-sectional view showing another three-dimensional applicator of the present invention.
  • Figure 1 is a perspective view of a three-dimensional applicator of the present invention.
  • Figure 2 is a cross-sectional view of a three-dimensional applicator of the present invention.
  • Figure 3 is an exploded view of the three-dimensional applicator of the present invention.
  • Figure 4 is a cross-sectional view showing the exploded state of the three-dimensional applicator of the present invention.
  • Figure 5 is a plan view of the pressure-retaining support cylinder of the present invention.
  • Fig. 6 is a schematic view showing the direction of the powder W of the three-dimensional applicator of the present invention.
  • a three-dimensional applicator of the present invention comprises: a pressure grinding cover 1, a pressure grinding support cylinder 2, and a support cup 3.
  • the pressure grinding cover 1 includes at least one annular side wall, and a partitioning platform 11 is disposed in the annular side wall.
  • the first surface of the partitioning platform 11 forms a first grinding surface 12.
  • the pressure grinding support cylinder 2 includes at least a support platform, a cylindrical boss 21 protruding from the support platform toward the first side, and an annular outer wall 24 surrounding the cylindrical boss 21; the end surface of the cylindrical boss 21 forms a second grinding surface 22
  • the second press surface 22 is combined with the annular outer wall 24 to form a crushing space 28.
  • a support platform located between the outer circumference of the cylindrical boss 21 and the annular outer wall 24 is provided with a plurality of powder leakage holes 26.
  • the cup 3 is screwed to the second side of the support cylinder 2 for receiving the powder W dropped from the powder leakage hole 26 after the tablet Y is ground.
  • the annular side wall of the pressure grinding cover 1 is self-pressing the support cylinder 2
  • the first side enters the embossing space 28, and the first embossing surface 12 cooperates with the second embossing surface 22 to form a first pair of embossing surfaces, the inner wall of the annular side wall of the embossing cover 1 and the cylindrical bulge of the embossing support cylinder 2
  • the clearance between the side walls of the table 21 forms a second pair of press faces, the first pair of press faces being in communication with the second pair of press faces.
  • the present invention is a segmented grinding structure in which the first pair of pressing surfaces and the second pair of pressing surfaces are not in one plane, so that the powder W passes through the first direction at different inclination angles (relative to the direction of gravity).
  • the speed of the pressing surface or the second pair of pressing surfaces is different.
  • the powder W is guided into the second pair of pressing surfaces, and the powder W can be effectively controlled.
  • the length of time that the second pair of press surfaces stays is small, which helps to perform finer grinding.
  • the powder W which is ground by the first pair of pressing surfaces is continuously guided away from the first pair of pressing surfaces, the powder W after the grinding can be prevented from accumulating on the first pair of pressing surfaces to prevent the pills.
  • Y is hard and difficult to smash and other characteristics and is stuck.
  • the first pressing surface 12 in this embodiment is recessed from the periphery toward the center to form a conical recess, and the second pressing surface 22 is formed to protrude from the periphery toward the center to form a conical structure, and the cone of the conical recess of the first pressing surface 12
  • the angle is equal to the cone angle of the conical structure of the second grinding surface 22, and the first pair of pressing surfaces is a conical surface, but is not limited thereto.
  • the conical surface structure of the first pair of pressing surfaces helps to grind the tablet Y, and the powder W is affected by gravity, and slides along the conical surface of the first pair of pressing surfaces toward the second pair of pressing surfaces.
  • the surface of the inner wall of the annular side wall of the press-polished cover 1 is provided with a third grinding tooth 17, and the surface of the side wall of the cylindrical boss 21 of the support cylinder 2 is fourth grinding tooth 29, the third grinding tooth and the fourth grinding
  • the teeth are alternately matched, and the second pair of pressing surfaces are round tube type pressing surfaces, but not limited thereto.
  • the third grinding teeth 17 and the fourth grinding teeth 29 are both very fine for finely grinding the powder W.
  • the first grinding surface 12 is recessed from the periphery toward the center to form a hemispherical dimple
  • the second pressing surface 22 is formed to protrude from the periphery toward the center to form a hemispherical projection
  • the first pair of pressing surfaces is a hemispherical surface
  • the second press surface 22 may include a plurality of powder leakage holes for rapidly grinding the powder W, but not limited thereto.
  • the distribution density of the powder leakage holes is gradually increased, so that the powder W is subjected to grinding as many times as possible, and then falls from the first pair of pressing surfaces.
  • the particle diameter of the small powder W is not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, but not limited to, buty, the distribution density of the powder leakage holes is gradually increased, so that the powder W is subjected to grinding as many times as possible, and then falls from the first pair of pressing surfaces. The particle diameter of the small powder W.
  • the first dressing surface 12 is provided with a plurality of protruding first grinding teeth 13, and the second grinding surface 22 is provided with a plurality of protruding second grinding teeth 23, the first grinding teeth 13
  • the distance between the first pressing surface 12 and the second pressing surface 22 changes to form a rhythmic amplitude in the height direction.
  • a minimum spacing is formed therebetween, and when the first pressing surface 12 and the second pressing surface 22 are oppositely supported, a maximum spacing is formed therebetween, and The rhythm amplitude is the difference between the maximum spacing and the minimum spacing.
  • the first grinding tooth 13 includes a plurality of radially linear first protrusions centered on the central axis of the press-fit cover 1, and the second grinding teeth 23 include a central axis of the cylindrical boss 21 A plurality of radially extending second protrusions of the center of the circle, the size and the gap of the first protrusion are equal to the size and the gap of the second protrusion, but are not limited thereto.
  • the first grinding tooth 13 includes a plurality of radial curved third protrusions centered on the central axis of the press-fit cover 1, and the second grinding teeth 23 include a central axis of the cylindrical boss 21
  • the fourth protrusion of the center of the plurality of radial curves, the size and the gap of the third protrusion are equal to the size and the gap of the fourth protrusion, but are not limited thereto.
  • the present invention also provides a method of using a stereo drug applicator for grinding a tablet Y, based on the above-described stereo drug applicator, the method of use comprising: a vertical rapid grinding state or a tilting fine grinding state.
  • the vertical rapid grinding state includes: placing the tablet Y, and after inserting the pressure grinding cover 1 into the pressure grinding support cylinder 2, keeping the central axis of the pressure grinding support cylinder 2 in the direction of gravity, and spinning the pressure grinding cover 1 toward the pressure grinding support cylinder 2,
  • the powder Y after the tablet Y is ground is ground by the first pair of pressing surfaces and guided to the second pair of pressing surfaces to continue grinding;
  • the oblique fine grinding state includes: placing the tablet Y, and inserting the pressing cover 1 into the pressing support tube 2 Thereafter, the center axis of the press-braking support cylinder 2 is inclined to the direction of gravity, and the press-grinding cover 1 is spun to the press-braking support cylinder 2, and the powder W after the grinding of the tablet Y is ground by
  • the fineness of the powder W is determined, and the powder W particles must be less than or equal to the gap to pass and fall.
  • the powder W is slowly passed through the second pair of pressing surfaces, and the gap between the second pair of pressing surfaces is small, the best grinding effect can be obtained.
  • FIGs. 7 to 11 are schematic views showing the flow of use of the three-dimensional pressure applicator of the present invention.
  • Fig. 7 and Fig. 8 are schematic views showing the disassembly and assembly of the three-dimensional applicator of the present invention.
  • the use of the spinning state of the present invention is as follows: first, the inverted stereo drug press And the press cover 1 and the press support cylinder 2 are unscrewed, and the tablet Y is placed in the first press face 12 of the press cover 1.
  • the press-reduction support cylinder 2 is screwed into the press-grinding cover 1, and the first grinding surface 12 of the press-grinding cover 1 and the second grinding surface 22 of the press-grinding support cylinder 2 are pressed against the tablet Y, and the inverted stereo-type pressing is performed. (ie the normal direction of recovery).
  • Figure 12 is a schematic view showing a state of oblique fine grinding of the three-dimensional applicator of the present invention.
  • Figure 13 is a schematic view showing another oblique fine grinding state of the three-dimensional applicator of the present invention.
  • the oblique fine grinding state of the present invention during the grinding process includes: placing the tablet Y, and after inserting the press cover 1 into the press-bracket support cylinder 2, tilting the center axis of the press-bracket support cylinder 2 to In the direction of gravity, the press-grinding cover 1 is spun to the press-supporting cylinder 2, and the powder W after the tablet Y is ground is ground by the first pair of pressing surfaces and guided to the second pair of pressing surfaces to continue grinding.
  • the time during which the powder Y after the tablet Y is ground passes through the second pair of pressing surfaces is greater than the time during which the powder W passes through the second pair of pressing surfaces in the vertical rapid grinding state.
  • the larger the inclination angle of the center axis of the press-supporting support cylinder 2 with the gravity direction the smaller the particle diameter of the powder W.
  • the angle O between the axis of the three-dimensional applicator and the direction of gravity P is C.
  • the angle O between the axis O of the three-dimensional applicator in Fig. 13 and the direction of gravity P is D. Since the angle D is greater than the angle C, compare Figure 12 And 13, the first pair of pressing faces of the stereo drug press of Fig.
  • the first pair of pressing faces of the stereo drug press are closer to the vertical gravity direction, and the powder W after the tablet Y is ground quickly passes through the second pair of pressing faces, at which time the powder W is pressed by the second pair of pressing faces.
  • the chance of grinding is less; while the first pair of pressing faces of the stereoplaster in Fig. 13 is at an angle with respect to the vertical direction of gravity, at which time the powder W will slowly pass through the second pair of pressing faces, during which the powder is
  • the chance and time for the W to be ground by the second pair of press faces is greatly increased, and the powder W having a smaller particle size after being ground for a plurality of times by the second pair of press faces falls into the cup 3 through the powder leakage holes 26. Subsequently, the powder W in the cup 3 can be taken by unscrewing the cup 3 and pressing the support cylinder 2.
  • Figure 14 is a perspective view of another three-dimensional applicator of the present invention.
  • Figure 15 is a cross-sectional view of the three-dimensional applicator of Figure 14.
  • Figure 16 is a cross-sectional view showing the exploded state of the three-dimensional applicator of Figure 14.
  • Figure 17 is a cross-sectional view of the three-dimensional applicator of Figure 14.
  • Figure 18 is a plan view of the press-supporting cylinder of Figure 14.
  • Figure 19 is a partial enlarged view of Figure 17.
  • a three-dimensional applicator of the present invention comprises: a press grinding cover 1, a press grinding support cylinder 2, and a support cup 3.
  • the pressure grinding cover 1 includes at least one annular side wall, and a partitioning platform 11 is disposed in the annular side wall.
  • the first surface of the partitioning platform 11 forms a first grinding surface 12.
  • the pressure grinding support cylinder 2 includes at least a support platform, a cylindrical boss 21 protruding from the support platform toward the first side, and an annular outer wall 24 surrounding the cylindrical boss 21; the end surface of the cylindrical boss 21 forms a second grinding surface 22
  • the second press surface 22 is combined with the annular outer wall 24 to form a crushing space 28.
  • a support platform located between the outer circumference of the cylindrical boss 21 and the annular outer wall 24 is provided with a plurality of powder leakage holes 26.
  • the cup 3 is screwed to the second side of the support cylinder 2 for receiving the powder W dropped from the powder leakage hole 26 after the tablet Y is ground.
  • the annular side wall of the pressure grinding cover 1 enters the grinding space 28 from the first side of the pressure grinding support cylinder 2, and the first grinding surface 12 and the second grinding surface 22 cooperate to form a first pair of pressing surfaces, and the grinding cover 1
  • the inner wall of the annular side wall cooperates with the side wall of the cylindrical boss 21 of the pressure-retaining support cylinder 2 to form a second pair of pressing surfaces, and the first pair of pressing surfaces are in communication with the second pair of pressing surfaces.
  • the press-grinding cover 1 includes a first annular side wall 16 and a second annular side wall 14, the first grinding surface 12 is formed in the second annular side wall 14, and the second annular side wall 14 is wrapped around the first annular side After the wall 16, the inner wall of the second annular side wall 14 is provided with a first loose fit wide pitch thread 15; the outer wall of the annular outer wall 24 of the press support sleeve 2 is provided with a second loose fit wide pitch thread 25, and the grinding cover 1
  • the first annular side wall 16 is inserted between the annular outer wall 24 of the press-retaining support cylinder 2 and the cylindrical boss 21, and the inner wall of the second annular side wall 14 is screwed to the outer wall of the annular outer wall 24.
  • the thread slot width E of the first loose fit wide pitch thread 15 and the second loose fit wide pitch thread 25 are both greater than or equal to the sum of the thread width F and the rhythmic amplitude.
  • the first pressing surface 12 is recessed from the periphery toward the center to form a conical recess, and the second pressing surface 22 is formed to protrude from the periphery toward the center to form a conical structure, and the conical angle of the conical pit of the first grinding surface 12 and the second pressure
  • the conical angle of the conical surface of the grinding surface 22 is equal, and the first pair of pressing surfaces are conical surfaces.
  • the first pressing surface 12 of the three-dimensional applicator is provided with a plurality of protruding first grinding teeth 13, and the second pressing surface 22 is provided with a plurality of protruding second grinding teeth 23.
  • the annular side wall of the pressure grinding cover 1 is provided with a first loose-fit wide-width thread 15 for pressing the annular outer wall 24 of the support cylinder 2
  • a second loose fit wide pitch thread 25 is provided, and the first loose fit wide pitch thread 15 is threadedly engaged with the second loose fit wide pitch thread 25.
  • the present invention is a segmented grinding structure in which the first pair of pressing surfaces and the second pair of pressing surfaces are not in one plane, so that the powder W passes through the first direction at different inclination angles (relative to the direction of gravity).
  • the speed of the pressing surface or the second pair of pressing surfaces is different.
  • the powder W is guided into the second pair of pressing surfaces, and the powder W can be effectively controlled.
  • the length of time that the second pair of press surfaces stays is small, which helps to perform finer grinding.
  • the powder W which is ground by the first pair of pressing surfaces is continuously guided away from the first pair of pressing surfaces, the powder W after the grinding can be prevented from accumulating on the first pair of pressing surfaces to prevent the pills.
  • Y is hard and difficult to smash and other characteristics and is stuck.
  • the applicator of the present invention can be used not only for pressing the tablets, but also for pressing the fruits, seasonings, confectionery, etc., which need to be ground or food, which can also save time and effort, and is easy to clean. No pollution effect.
  • the crushing is performed in the early and middle stages of the press grinding (step S100) and the late pressing (step S200). Introduced as follows:
  • Step S100 crushing to the early and middle stage of the pressing (there are more tablets Y crushing the tablet Y particles between the pressing surfaces, and the pressing surface grinding teeth are indirectly staggered), and the step S100 includes the following steps:
  • Step S101 when the cap is started, since there is no resistance on the pressing surface, under the action of gravity, the lower surface of the grinding cap and the upper surface of the pressing support cylinder are in contact with each other and follow the spiral path, and the thread has no force. behavior.
  • Step S102 when the pressing surface of the pressure grinding cover contacts the tablet Y, the resistance of the tablet Y rises up until the upper surface of the threaded cover thread is in contact with the lower surface of the threaded support cylinder thread, and the threading starts to force to break. .
  • Step S103 when the tablet Y is fragile or the tablet Y is small, the resistance is small, the thread force directly breaks the tablet Y, and there is no jamming, and the broken tablet Y large particle acts on the edged pressing surface.
  • the lower thread is broken up and continues to be ground, and the wide-distance thread does not work until the later stage of the pressing (there are fewer tablets Y broken particles between the pressing surfaces, and the grinding surface is directly staggered).
  • Step S104 when the tablet Y is hard or the tablet Y is more, the resistance is large, and after the thread is applied, the pressing surface is descended, and the tablet Y is stuck in the edge of the upper and lower pressing surface to form a stuck condition, and at this time, a certain angle needs to be rotated ( It can be 0°-360°).
  • the upper surface of the pressure-receiving cover thread and the lower surface of the pressure-receiving support cylinder are separated to produce a free-running gap, which provides a wide-distance thread action stroke.
  • the pressure grinding The surface pressure grinding tooth changes the position of the tablet Y, which is beneficial to the next thread breaking force.
  • the wide-width thread groove width can be grounded as long as the tooth width is larger than the tooth width, and the larger the groove width (pitch), the larger the in-situ rotation angle.
  • step S200 in the later stage of press grinding (there are fewer tablets Y crushing particles between the pressing surfaces, and the pressing surface grinding teeth are directly staggered) to the cleaning period state, step S200 includes the following steps:
  • step S201 the post-grinding medicine will be less and less, and the pressing grinding teeth will start to be in direct contact. If the screwing is continued, (the upper surface of the grinding cap and the lower surface of the pressing support cylinder thread are in contact with each other), then it will appear at a certain angle. The grinding teeth are stuck. In extreme cases (cleaning phase), the thread will lock up. Therefore, it is not necessary to screw in at the end of the grinding process. It only needs to be directly interlaced (with a clear sound) at the beginning of the grinding tooth to perform the rounding, and enter the wide thread to play the second stage. .
  • Step S202 the wide-distance thread exerts the second action phase and the wide-distance thread in step S104 is different in the first action phase.
  • the broken tablet Y particles can be easily removed without applying the pressing force of the hand. Grind into powder and fall into the receiving bin.
  • step S203 and the cleaning stage referring to the above step S201, after the sounding of the grinding teeth is heard, the ground rotation is performed, and the grinding surface is interlaced with the grinding surface, and the regular ups and downs are performed to achieve the effect of flushing the residual powder W by the airflow. .
  • Step S204 the amplitude and frequency of the rhythm depending on the cleaning effect, and the method for increasing the amplitude of the rhythm is that the grinding teeth are more deeply staggered, and the width of the wide thread groove is at least larger than the tooth width + the height of the grinding tooth, so that a large rhythmic amplitude can be realized.
  • the tooth width is constant, the larger the groove width (pitch), the larger the achievable rhythm. The deeper the interdental degree of the grinding teeth, the better the effect of the grinding and scattering of the tablet Y broken particles in the second action stage.
  • the rhythmic frequency is positively correlated with the number of grinding teeth, but the number of grinding teeth is less constrained by the wide pitch thread.
  • the cooperation of the first loose-fit wide-width thread 15 and the second loose-fit wide-distance thread 25 in the present invention can achieve the labor-saving effect by the screw drive, and can realize the reciprocating grinding effect of the grinding surface being separated from the thread drive without separation. .
  • the threaded peaks and thread valleys of the loose fit drive thread can achieve a helical fit, but are different from conventional threads.
  • There is a free gap between the two threads which is much larger than the normal thread matching clearance (generally a working range of about 0.3 mm). In actual practice, the gap is about 2-3 mm, and the actual distance may be 2-3 cm.
  • the thread groove width E of the first loose fit wide pitch thread 15 and the second loose fit wide pitch thread 25 are both greater than or equal to the sum of the thread width F and the rhythmic amplitude, and the pressure is made by the fit gap
  • the cover has a section that is free to move up and down relative to the support cylinder and is free to "in situ", ie, it is rotated but not subject to the thread and must be moved in or out.
  • the loosely matched drive thread can realize the forward rotation linear drive advancement of the conventional threaded engagement, assist the crushing of the tablet Y, and the reverse rotation linear drive back to separate the pressure grinding cover and the support cylinder.
  • the thread drive advances, which can assist the crushing of the tablet Y into a large piece until it is difficult to recompress; the slight reverse rotation causes the pressure grinding cover to enter the range of “free wide-distance thread gap”, and the pressure-grinding cover can be controlled and operated at the hand.
  • the continuous reciprocating rotary grinding operation in which the second pressing surface 22 is not separated is performed on the press-reduction support cylinder 2, and the pressing surface is reciprocated close/away as the standard thread of the prior art rotates. Effective grinding is not possible.
  • the loose fit wide pitch thread in the present invention means that the thread groove width of the thread is significantly larger than the thread.
  • the width of the teeth allows the thread width to move up and down within the width of the thread groove.
  • the height of the first grinding tooth protruding from the first pressing surface ranges from 0.1 mm to 10 mm; the height of the second grinding tooth protruding from the second pressing surface is 0.1 Mm to 10 mm; the range of the thread width of the first loose fit wide pitch thread and the second loose fit wide pitch thread is 0.1 Up to 10 mm; the thread groove width of the first loose fit wide pitch thread and the second loose fit wide pitch thread is in the range of 0.2 to 20 mm.
  • Figure 20 is a schematic view of the threaded engagement of the spinning state of the present invention.
  • the press-fit cover 1 of the present invention can be engaged by the first loose-fit wide-width thread 15 and the second loose-fit wide-width thread 25 in the spinning state, the first loose fit width
  • the thread 15 is in close contact with the second loose-fit wide-distance thread 25, and the pressure-grinding cover 1 can perform the spinning reduction in the axial direction, and the first pressing surface 12 of the driving-polished cover 1 is pressed against the second of the pressure-retaining support cylinder 2 Tablet Y of the press surface 22 .
  • the spinning state is very helpful for breaking the tablet Y at the beginning.
  • Figure 21 is a schematic view of the threaded engagement in the ground state of the present invention. As shown in Fig. 21, but when the stacking of the powder W is not carried out, when it is impossible or difficult to continue the spinning down, the counter-rotating is to press the cap into the "free zone".
  • the thread width in the present invention can be moved up and down within the range of the thread groove width, even if the first loose fit wide thread 15 and the second loose fit wide thread 25 are suspended, even the first loose fit width
  • the rotation of the thread 15 is performed at a certain angle, and the height between the pressure grinding cover 1 and the pressure grinding support cylinder 2 does not change any more, which is equivalent to the height of the pressure grinding support cylinder 2 relative to the pressure grinding support cylinder 2.
  • the tablet Y of the second dressing surface 22 of the press support cylinder 2 is ground. The grinding state is very advantageous for solving the problem of jamming when the powder W is piled up.
  • the spinning state and the grinding state in the present invention can be flexibly used as long as the tablet Y can be ground by the spinning state and used in the spinning state (the first loose-fit wide-width thread 15 is closely attached to the second loose-fit width). Thread 25, for spinning down).
  • the reverse rotation retracting thread can enter the "free up and down" interval due to the resistance of the bite, and the first pressing surface 12 is always maintained relative to the second pressing surface.
  • the press-grinding cover 1 can realize the in-situ rotary grinding with respect to the height of the press-supporting support cylinder 2, rapidly destroying the stacked shape of the powder W, and after continuing to grind the powder W, the first loose fit wide-distance thread After 15, it can be lowered against the second loose-fit wide-width thread 25, and the spin-down is again performed (returning to the spinning state).
  • rotary applicators use standard threads.
  • the thread groove width in prior art rotary applicators is almost equal to the thread width.
  • the tablet Y is stuck, it cannot continue to rotate downward. After the powder W is pressed in, it is almost integrated and cannot be pressed down, so it can only be reversed and the partial thread can be withdrawn.
  • the prior art cannot achieve the effect of the flexible replacement of the spinning state and the grinding state in the present invention.
  • first lapping tooth 13 and the second lapping tooth 23 of the present invention are alternately alternated between staggered engagement and abutment to form a rhythmic fit.
  • the interlaced engagement in the present invention means that each of the first grinding teeth 13 at least partially enters the gap of the adjacent two second grinding teeth 23, and likewise, each of the second grinding teeth 23 at least partially enters the phase. In the gap between the two adjacent first grinding teeth 13. This minimizes the spacing between the first press surface 12 and the second sand surface 22.
  • the abutment in the present invention means that the tip of each of the first grinding teeth 13 is in supporting contact with the tip of the corresponding second grinding tooth 23, and the first grinding tooth 13 does not enter the gap of the second grinding tooth 23.
  • the second grinding teeth 23 do not enter the gap of the first grinding teeth 13. This maximizes the spacing between the first press surface 12 and the second sand surface 22.
  • the effect of the rhythmic grinding of the first grinding tooth 13 and the second grinding tooth 23 can more quickly destroy the shape of the powder W stack, The problem of stuck when the drug powder W is piled up.
  • the rhythmic effect of the first grinding tooth 13 and the second grinding tooth 23 or other special grinding surface can not achieve the "adhesive" grinding action of the two surfaces if the ordinary thread of the prior art drug press is used. Because the standard pitch of ordinary threads is not allowed. However, if the wide-distance thread is used, the optimal rhythmic tooth height, the shape and the free stroke of the wide-distance thread can be combined to effectively realize the grinding action and assist in the rapid production of finer powder.
  • the outer periphery of the press-retaining support cylinder 2 is further provided with an outer shoulder 27, and the second annular side wall 14 abuts the outer shoulder 27.
  • a rhythmic force is formed as the first grinding tooth 13 and the second grinding tooth 23 are alternately alternated between the staggered engagement and the abutment.
  • the second annular side wall 14 can repeatedly crimp the outer shoulder 27 (corresponding to the sealed state) or leave the outer shoulder 27 with a certain gap (which can be supplied with air). This repeated alternating inhalation state can be rhythmically
  • the air is guided into the pressing space 28 for blowing off the powder W adhering to the surface of the first pressing surface and the surface of the second pressing surface, and has a function of self-cleaning.
  • the number and height of the grinding teeth are positively related to the frequency of the “rhythm” or the effect of generating airflow, which is convenient for adjusting the self-cleaning effect.
  • the first pair of pressing surfaces, the second pair of pressing surfaces, the segmented grinding structure, the loose fit wide thread screwing structure and the grinding toothed dynamic matching are combined to obtain the fastest grinding.
  • the effect helps to quickly grind the powder W and saves effort.
  • Figure 22 is a cross-sectional view showing another three-dimensional applicator of the present invention. As shown in Fig. 22, in a variant, the holder cup 3 of the press-grinding cover 1 and the second side of the press-receiving support cylinder 2 are combined to form a storage compartment 3 in which the cartridge 32 can be placed.
  • Figure 23 is a cross-sectional view showing another three-dimensional applicator of the present invention.
  • the press-grinding cover 1 includes a first annular side wall 16, and the outer wall of the first annular side wall 16 is provided with a first loose-fit wide-width thread 15;
  • the inner wall of the annular outer wall 24 is provided with a second loose fit wide pitch thread 25, the outer wall of the first annular side wall 16 being threaded into the inner wall of the annular outer wall 24.
  • the pressure grinding cover 1 only needs to be provided with an annular side wall, which saves cost, but compared to the two annular side walls (ie, the second annular side wall 14, the first annular side wall 16), the powder W will Relatively easy to spread out.
  • the three-dimensional pressure applicator of the present invention and the method of using the same make the pressing process time-saving and labor-saving, and can adjust the thickness of the powder to meet the oral or nasal feeding (requires the syringe to extract the dissolved powder into the nasal feeding tube, so The powder needs to be ground more carefully) for patients with different thicknesses of powder.
  • the invention has the following advantages:
  • the three-dimensional applicator of the present invention can control the time during which the powder of the tablet passes through the pressing surface by the cooperation of the two-stage first pressing surface and the second pressing surface, and the inclination angle is larger. The longer the powder passes through the second pressing surface, the finer the powder is ground.
  • the screwing position of the first loose-fit wide-width thread and the second loose-fit wide-width thread in the present invention is outside the pressing space, and the first loose-fit wide-width thread and the second loose-fit wide-width thread can be prevented.
  • the threaded worn powder falls into the crushed powder.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Preparation (AREA)
  • Crushing And Grinding (AREA)

Abstract

L'invention concerne un dispositif de pressage de médicament stéréoscopique et son procédé d'utilisation. Le dispositif de pressage de médicament stéréoscopique comprend : un couvercle de pressage et de broyage (1) et un cylindre de support de pressage et de meulage (2), le couvercle de pressage et de meulage (1) comprend au moins une paroi latérale annulaire, une plate-forme de séparation (11) est disposée dans la paroi latérale annulaire, et une première face de la plate-forme de séparation (11) forme une première face de pressage et de meulage (12) ; et le cylindre de support de pressage et de meulage (2) comprend au moins une plateforme de support, un bossage cylindrique (21) faisant saillie de la plate-forme de support vers un premier côté, et une paroi externe annulaire (24) entourant le bossage cylindrique (21). La face d'extrémité du bossage cylindrique (21) forme une seconde face de pressage et de meulage (22), et la seconde face de pressage et de meulage (22) encercle un espace de pressage et de meulage (28) avec la paroi externe annulaire (24) ; la paroi latérale annulaire du couvercle de pressage et de broyage (1) entre dans l'espace de pressage et de broyage (28) depuis un premier côté du cylindre de support de pressage et de meulage (2), et la première face de pressage et de meulage (12) correspond à la seconde face de pressage et de meulage (22) pour former une première paire de faces de pressage et de meulage; et une paroi interne de la paroi latérale annulaire du couvercle de pressage et de broyage (1) correspond à une paroi latérale du bossage cylindrique (21) du cylindre de support de pressage et de meulage (2) pour former une seconde paire de faces de pressage et de meulage, et la première paire de faces de pressage et de meulage est en communication avec la seconde paire de faces de pression et de meulage. Le dispositif de pressage de médicament stéréoscopique économise du temps et du travail pendant le processus de pressage de médicament, et il peut également ajuster le degré de finition d'une poudre de médicament.
PCT/CN2017/109475 2017-09-27 2017-11-06 Dispositif de pressage de médicament stéréoscopique et son procédé d'utilisation WO2019061679A1 (fr)

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CN201710889163.3A CN109549851B (zh) 2017-09-27 2017-09-27 立体式压药器及其使用方法
CN201710889163.3 2017-09-27

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USD984671S1 (en) 2020-12-09 2023-04-25 Studio 010 Inc. Mortar and pestle

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US5553793A (en) * 1993-12-15 1996-09-10 Lake Medical Products, Inc. Combination pill crushing and dispensing cup
DE19706341A1 (de) * 1996-10-29 1998-05-20 Martin Zak Vorrichtung zum Zerkleinern von Tabletten
CN106040391A (zh) * 2016-07-29 2016-10-26 扬州锦盛微粉有限公司 一种微粉制造机
US20160310366A1 (en) * 2015-04-22 2016-10-27 Ann Evans Pill Crushing Device For Pulverizing Pills And Minimizing Transfer Loss Of Pulverized Pills
CN107157772A (zh) * 2017-06-29 2017-09-15 杭州小橙工业设计有限公司 一种实现药片大批量流水化间隔粉碎的电动碾药器
CN206509080U (zh) * 2017-01-17 2017-09-22 云南绿生中药科技股份有限公司 一种中草药超细研磨机

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US5322227A (en) * 1993-01-26 1994-06-21 James Fiocchi Combination pulverizer and closure device
CN202290236U (zh) * 2011-07-22 2012-07-04 卞海兵 碾粉磨泥套筒
CN203001452U (zh) * 2012-12-25 2013-06-19 十堰市太和医院 一种碾药器
TWM469913U (zh) * 2013-10-24 2014-01-11 hui-ling Xiao 磨藥器結構
CN208464668U (zh) * 2017-09-27 2019-02-05 杨松 立体式压药器

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Publication number Priority date Publication date Assignee Title
US5553793A (en) * 1993-12-15 1996-09-10 Lake Medical Products, Inc. Combination pill crushing and dispensing cup
DE19706341A1 (de) * 1996-10-29 1998-05-20 Martin Zak Vorrichtung zum Zerkleinern von Tabletten
US20160310366A1 (en) * 2015-04-22 2016-10-27 Ann Evans Pill Crushing Device For Pulverizing Pills And Minimizing Transfer Loss Of Pulverized Pills
CN106040391A (zh) * 2016-07-29 2016-10-26 扬州锦盛微粉有限公司 一种微粉制造机
CN206509080U (zh) * 2017-01-17 2017-09-22 云南绿生中药科技股份有限公司 一种中草药超细研磨机
CN107157772A (zh) * 2017-06-29 2017-09-15 杭州小橙工业设计有限公司 一种实现药片大批量流水化间隔粉碎的电动碾药器

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