WO2019015131A1 - 一种用于治疗心律失常的中药 - Google Patents

一种用于治疗心律失常的中药 Download PDF

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WO2019015131A1
WO2019015131A1 PCT/CN2017/105430 CN2017105430W WO2019015131A1 WO 2019015131 A1 WO2019015131 A1 WO 2019015131A1 CN 2017105430 W CN2017105430 W CN 2017105430W WO 2019015131 A1 WO2019015131 A1 WO 2019015131A1
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chinese medicine
traditional chinese
ginseng
schisandra
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PCT/CN2017/105430
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English (en)
French (fr)
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田丽华
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淄博齐鼎立专利信息咨询有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Definitions

  • the invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating arrhythmia.
  • bradyarrhythmia is more, the pathogenesis is more complicated, is caused by autonomic sinus node damage caused by sinus node failure, pacing dysfunction, or sinus node, atrium, atrioventricular node And the atrioventricular bundle disease caused conduction dysfunction, so that the excitatory activation of the sinus node can not be normally transmitted.
  • the clinical manifestations are mainly pulse dysfunction, accompanied by palpitations, chest tightness, shortness of breath, and so on. In severe cases, there may be Arsenal syndrome or even death. Classification includes sinus bradycardia, atrioventricular block, and sick sinus syndrome.
  • the evidence shows that the cold limbs are cold, the complexion is pale, the lips are purple, the dry tongue is white, the veins are thin or have no generation, or the moss White is slightly greasy, the tongue is light, the tongue is fat, the pulse is late or there is a generation.
  • Ginseng stick hammer, ginseng, garden ginseng, ginseng leaf.
  • This product is the dry root of the ginseng of the Araliaceae plant.
  • the growers are "gardens” and the wild ones are “mountain”. More than autumn mining, washing; garden ginseng dried or dried, called “raw ginseng”; ginseng dried, called “raw sun ginseng”; after hot water, dipped in sugar and dried, said " White sugar ginseng”; dried or dried after steaming, called “red ginseng”.
  • Schisandra [alias] ⁇ , ⁇ , Xuanhe, will, five plums, North Schisandra, Liao Wuzi.
  • This product is a dry mature fruit of the Magnoliaceae Schisandra or Huazhong Schisandra. The former is called “Northern Schisandra”, and the latter is called “Southern Schisandra.”
  • the autumn fruit is ripe, it is picked, dried or steamed, and dried to remove the fruit stems and impurities.
  • [Functions and Indications] Convergence and solidification, benefit Qi and fluid, and replenish kidney and Ningxin.
  • Raw land [alias] Rehmannia, medulla, yangjing, benzyl, milk root, dog milk root, mother-in-law root, mountain smog root, mountain smog roots, mountain roots, mountain cabbage roots, hip flask roots, Wine cellar roots, sweet wine roots, honey pot roots, habitat, Dashengdi, Xiaoshengdi, dry land, habitat, and rehmannia root.
  • [Source] is the dry root of Dioscorea zingiberensis.
  • Angelica [alias] dry back.
  • This product is the dried root of Angelica sinensis. At the end of autumn, the excavation is carried out to remove the roots and sediments. After the water has evaporated slightly, it is bundled into small pieces and placed on the shed, and slowly dried out with fireworks.
  • Gan, Xin, Wen. [Return to the classics] to the liver, heart, spleen.
  • Guizhi Liu Gui. [Source] This product is a dry shoot of cinnamon of the family Polygonaceae. Harvested in spring and summer, remove leaves, dry, or slice and dry. [Sexual taste] Xin, Gan, warm. Return to Heart, lung, bladder. [Indications] Sweat and muscle, Wentong meridian, help yang gas, flat flushing. For cold, cold, abdominal pain, cold blood stasis, joint pain, sipping, edema, heart palpitations, porpoise. [Usage and dosage] Oral: Jiantang, 3 ⁇ 10g. [Note] The syndrome of warm disease and yin deficiency and yang deficiency, blood test, and pregnant women should not take it. [Excerpt] "Chinese Materia Medica”.
  • Bairenzi [alias] Baishi, Baizi, Bairen, and Baibaizi.
  • This product is a dry mature seed of the cypress plant. Mature seeds are harvested in the autumn and winter seasons, dried, and the seed coat is removed to collect the seed kernels.
  • Gan, Ping. [Return] to the heart, kidney, large intestine.
  • [Functions and Indications] Nourish the heart and calm the nerves For virtual troubles, insomnia, heart palpitations, yin and night sweats, intestinal dry constipation.
  • Baiziren is more oily, and the intestines are not allowed to take the diarrhea. If you don't take it, the number of the sun will be increased, the kidneys will have heat, and the heat will be used for diarrhea.
  • [Excerpt] "Chinese Materia Medica”.
  • Yuanzhi [alias] grass, fine grass, chicken legs, fine leaves, Zhizhi, line tea.
  • This product is the dry root of Polygalaceae plant Polygala or Ophiopogon japonicus. Excavation in spring and autumn, removing stubble and sediment, and drying. [Sexual taste] bitter, spicy, warm. [Return] to the heart, kidney, lung. [Indications] Anshen puzzle, sputum, swelling. For insomnia caused by heart and kidney disharmony, forgetfulness, convulsions, convulsions, coughing, sore swollen, breast swelling and pain. [Usage and dosage] Oral: Jiantang, 3 ⁇ 9g. [Note] Defective, winter sunflower, keel good. Fear of true beads, gourd, scorpion, Qi Qi. [Excerpt] "Chinese Materia Medica”.
  • the invention aims to provide a traditional Chinese medicine for treating arrhythmia, and to achieve a safe and effective cure for arrhythmia by selecting a suitable medicinal material and its ratio.
  • a traditional Chinese medicine for treating arrhythmia which is prepared by the following raw materials of weight ratio: 10 parts of white, 10 parts of ginseng, 15 parts of schisandra, 25 parts of raw land, 10 parts of angelica, cassia twig 10 copies, 12 gods, 15 Bairenzi, 10 Yuanzhi.
  • angina pectoris shortness of breath, peripheral vascular failure, acute heart failure, acute myocardial infarction; (2) dizziness, fatigue, blurred vision, temporary blindness, even aphasia, paralysis Transient or permanent brain damage such as convulsions and coma.
  • dizziness fatigue, blurred vision, temporary blindness, even aphasia, paralysis Transient or permanent brain damage such as convulsions and coma.
  • Insufficient blood supply to the renal artery, oliguria, proteinuria, and azotemia Insufficient blood supply to the mesenteric artery, abdominal distension, abdominal pain, diarrhea, and even bleeding, ulceration or paralysis.
  • the manifestations of cardiac insufficiency are mainly cough, difficulty breathing, fatigue, fatigue and so on.
  • the treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention 3 times a day.
  • the treatment lasts for one month.
  • the control group received oral rheumatoid and amiodarone (taken according to the instructions). The treatment lasts for one month.
  • the medicine prepared by the invention can safely and effectively treat arrhythmia and has the promotion value.

Abstract

一种中药，原料药为：薤白10份、人参10份、五味子15份、生地25份、当归10份、桂枝10份、茯神12份、柏仁子15份、远志10份。该中药能够治疗心律失常。

Description

一种用于治疗心律失常的中药 技术领域
本发明涉及一种中药，具体涉及一种用于治疗心律失常的中药。
背景技术
现代研究认为，缓慢性心律失常的发病因较多，发病机理较复杂，是由窦房结自律性受损致窦房结功能衰竭、起搏功能障碍，或窦房结、心房、房室结及房室束病变致传导功能障碍，使窦房结的兴奋激动不能正常下传所致。临床表现以脉搏迟缓为主，伴有心悸、胸闷、气短乏力等，严重者可出现阿一斯氏综合征，甚至死亡。分类包括窦性心动过缓、房室传导阻滞、病态窦房结综合征等。
中医认为，本病属“心悸”、“胸痹”、“眩晕”、“怔忡”等范畴，病位在心，而本质在脾肾，表现为阳气虚衰，心肾阳虚，脾气不足，气血运行无力，致心阳虚损，气血凝滞。中医临床症状均表现为不同程度的胸闷气短、神疲乏力、心悸、头晕甚至晕厥，证见形寒肢冷，面色无华，口唇紫绀，舌干苔薄白，脉细或有结代，或苔白微腻、舌质淡、舌体胖大、脉沉迟或有结代。
本发明所涉及药材研究现状如下：
薤白【别名】薤根(《肘后方》)，藠头(《陆川本草》)，大头菜子(《新疆药材》)，野蒜、小独蒜(《中药形性经验鉴别法》)，小蒜、宅蒜(《河北药材》)，薤白头。【来源】为百合科植物小根蒜或薤的鳞茎。北方多在春季，南方多在夏秋间采收。连根挖起，除去茎叶及须根，洗净，用沸水煮透，晒干或烘干。本品须置干燥处，防潮防蛀。【性味】辛，苦，温。【归经】入肝、肺、心经。【功能主治】理气，宽胸，通阳，散结。治胸痹心痛彻背，脘痞不舒，干呕，泻痢后重，疮疖。【用法用量】内服：煎汤，6～15g。【注意】气虚者慎服。【摘录】《中华本草》。
人参【别名】棒锤、山参、园参、参叶.【来源】本品为五加科植物人参的干燥根。栽培者为“园参”，野生者为“山参”。多于秋季采挖，洗净；园参经晒干或烘干，称“生晒参”；山参经晒干，称“生晒山参”；经水烫，浸糖后干燥，称“白糖参”；蒸熟后晒干或烘干，称“红参”。【性味】甘、微苦，平。【归经】归脾、肺、心经。【功能主治】大补元气，复脉固脱，补脾益肺，生津， 安神。用于体虚欲脱，肢冷脉微，脾虚食少，肺虚喘咳，津伤口渴，内热消渴，久病虚羸，惊悸失眠，阳痿宫冷；心力衰竭，心原性休克。【用法用量】内服：煎汤，3～9g。【注意】不宜与藜芦同用。【摘录】《中华本草》。
五味子【别名】菋、荎蕏，玄及，会及，五梅子、北五味子、辽五味子。【来源】本品为木兰科植物五味子或华中五味子的干燥成熟果实。前者习称“北五味子”，后者习称“南五味子”。秋季果实成熟时采摘，晒干或蒸后晒干，除去果梗及杂质。【性味】酸、甘，温。【归经】归肺，心、肾经。【功能主治】收敛固涩，益气生津，补肾宁心。用于久嗽虚喘，梦遗滑精，遗尿尿频，久泻不止，自汗，盗汗，津伤口渴，短气脉虚，内热消渴，心悸失眠。【用法用量】内服：煎汤，3～12g。【注意】外有表邪，内有实热，或咳嗽初起、痧疹初发者忌服。【摘录】《中华本草》。
生地【别名】地黄、地髓、阳精、苄根，牛奶子根、狗奶子根、婆婆奶根、山烟根，山旱烟生地药材根，山烟根，山白菜根、酒壶花根、酒盅盅花根、甜酒棵根、蜜罐棵根、生地、大生地、小生地、干生地、怀生地、地黄根。【来源】为玄参科植物地黄的干燥块根。【性味】味甘、苦，性微寒。【归经】归心、肝、肾经。质润降泄。【功能主治】清热凉血，用于温热病热入营血，壮热神昏，口干舌绛。治温病后期，余热未尽，阴液已伤，夜热早凉，舌红脉数者。可用于治温热病热入营血，血热毒盛，吐血衄血，斑疹紫黑。养阴生津功效用于津伤口渴，内热消渴。治温病伤阴，肠燥便秘。【用法用量】内服：煎汤，10～30g。【注意】性寒而滞，脾虚湿滞腹满便溏者，不宜使用。【摘录】《中华本草》。
当归【别名】干归。【来源】本品为伞形科植物当归的干燥根。秋末采挖，除去须根及泥沙，待水分稍蒸发后，捆成小把，上棚，用烟火慢慢熏干。【性味】甘、辛，温。【归经】归肝、心、脾经。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。【用法用量】内服：煎汤，10～25g。【注意】湿阻中满及大便溏泄者慎服。【摘录】《中华本草》。
桂枝【别名】柳桂。【来源】本品为樟科植物肉桂的干燥嫩枝。春、夏二季采收，除去叶，晒干，或切片晒干。【性味】辛、甘，温。【归经】归 心、肺、膀胱经。【功能主治】发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。【用法用量】内服：煎汤，3～10g。【注意】温热病及阴虚阳盛之证、血证、孕妇忌服。【摘录】《中华本草》。
茯神【别名】茯神木。【来源】茯苓菌核中间(白茯苓)抱有松根或细松木心者的部份。多切成薄方块，坚实。【性味】甘、平。【归经】入心、脾经。【功能主治】宁心，安神，利水。治心虚惊悸，健忘，失眠，惊痫，小便不利。【用法用量】内服：煎汤，6～15g。【摘录】《中华本草》。
柏仁子【别名】柏实，柏子、柏仁，侧柏子.【来源】本品为柏科植物侧柏的干燥成熟种仁。秋、冬二季采收成熟种子，晒干，除去种皮，收集种仁。【性味】甘，平。【归经】归心、肾、大肠经。【功能主治】养心安神，止汗，润肠。用于虚烦失眠，心悸怔忡，阴虚盗汗，肠燥便秘。【用法用量】内服：煎汤，6～15g。【注意】柏子仁体性多油，肠滑作泻者勿服，膈间多痰者勿服，阳道数举、肾家有热、暑湿作泻，法咸忌之。【摘录】《中华本草》。
远志【别名】小草、细草、小鸡腿、细叶远志、线茶。【来源】本品为远志科植物远志或卵叶远志的干燥根。春、秋二季采挖，除去须根及泥沙，晒干。【性味】苦、辛、温。【归经】归心、肾、肺经。【功能主治】安神益智，祛痰，消肿。用于心肾不交引起的失眠多梦，健忘惊悸，神志恍惚，咳痰不爽，疮疡肿毒，乳房肿痛。【用法用量】内服：煎汤，3～9g。【注意】得茯苓、冬葵子、龙骨良。畏真珠、藜芦、蜚蠊、齐蛤。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗心律失常的中药，通过选择合适的药材及其配比，达到安全有效治愈心律失常的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗心律失常的中药，其特征在于，它是由以下重量配比的原料药材制备而成：薤白10份、人参10份、五味子15份、生地25份、当归10份、桂枝10份、茯神12份、柏仁子15份、远志10份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院心律失常患者124例，随机分为治疗组62例与对照组62例，治疗组男32例，女30例，年龄45～84岁，平均年龄62.5岁；对照组男30例，女32例，年龄47～81岁，平均年龄60.5岁。病程2～15年。2组性别、年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国心律失常临床专业会议的诊断标准：(1)心绞痛、气短、周围血管衰竭、急性心力衰竭、急性心肌梗死；(2)头晕、乏力、视物模糊、暂时性全盲，甚至于失语、瘫痪、抽搐、昏迷等一过性或永久性的脑损害。(3)肾动脉供血不足的表现少尿、蛋白尿、氮质血症。(4)肠系膜动脉供血不足的表现腹胀、腹痛、腹泻，甚至发生出血、溃疡或麻痹。(5)心功能不全的表现主要为咳嗽、呼吸困难、倦怠、乏力等。
2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日3次。疗程一个月。
对照组口服心律平、胺碘酮(按说明书服用)。疗程一个月。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：症状及体征明显改善，24h平均心率较治疗前增加≥10次/分；
有效：症状及体征有所缓解，24h平均心率较治疗前增加≥5次/分；
无效：症状及体征无改善，24h平均心率较治疗前增加<5次/分。
3.2治疗结果见表1。
表1两组疗效比较
Figure PCTCN2017105430-appb-000001
可见，本发明制得的药物能够安全有效治疗心律失常，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：薤白10克、人参10克、五味子15克、生地25克、当归10克、桂枝10克、茯神12克、柏仁子15克、远志10克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗心律失常。口服，每日分早午晚三次服用。
实施例2
称取：薤白10克、人参10克、五味子15克、生地25克、当归10克、桂枝10克、茯神12克、柏仁子15克、远志10克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗心律失常。口服，每日分早午晚三次服用。
实施例3
称取：薤白10克、人参10克、五味子15克、生地25克、当归10克、桂枝10克、茯神12克、柏仁子15克、远志10克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗心律失常。口服，每日分早午晚三次服用。

Claims (4)

  1. 一种用于治疗心律失常的中药，其特征在于，它是由以下重量配比的原料药材制备而成：薤白10份、人参10份、五味子15份、生地25份、当归10份、桂枝10份、茯神12份、柏仁子15份、远志10份。
  2. 如权利要求1所述的用于治疗心律失常的中药，其特征在于，其制备方法为：称取：薤白10份、人参10份、五味子15份、生地25份、当归10份、桂枝10份、茯神12份、柏仁子15份、远志10份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
  3. 如权利要求1所述的用于治疗心律失常的中药，其特征在于，其制备方法为：称取：薤白10份、人参10份、五味子15份、生地25份、当归10份、桂枝10份、茯神12份、柏仁子15份、远志10份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
  4. 如权利要求1所述的用于治疗心律失常的中药，其特征在于，其制备方法为：称取：薤白10份、人参10份、五味子15份、生地25份、当归10份、桂枝10份、茯神12份、柏仁子15份、远志10份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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CN104758553A (zh) * 2015-04-17 2015-07-08 淄博夸克医药技术有限公司 一种用于治疗心律失常的中药

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CN1383846A (zh) * 2001-04-29 2002-12-11 王运景 一种治疗心脏病的强心通脉液
CN104758553A (zh) * 2015-04-17 2015-07-08 淄博夸克医药技术有限公司 一种用于治疗心律失常的中药

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