WO2018227829A1 - 一种用于治疗习惯性流产的中药 - Google Patents

一种用于治疗习惯性流产的中药 Download PDF

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WO2018227829A1
WO2018227829A1 PCT/CN2017/105514 CN2017105514W WO2018227829A1 WO 2018227829 A1 WO2018227829 A1 WO 2018227829A1 CN 2017105514 W CN2017105514 W CN 2017105514W WO 2018227829 A1 WO2018227829 A1 WO 2018227829A1
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chinese medicine
traditional chinese
habitual abortion
grams
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王淑英
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淄博齐鼎立专利信息咨询有限公司
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Definitions

  • the invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating habitual abortion.
  • miscarriage An important trait: chromosomal abnormalities, embryos and fetuses with abnormal karyotype are mostly accompanied by abnormal villus edema and/or atrophy of villus cells, which cannot continue to grow and are naturally eliminated.
  • habitual abortion The clinical manifestations of habitual abortion are the same as those of general abortion, and it is also a stage of experiencing threatened abortion, inevitable abortion, incomplete or complete abortion. In the early stage, it can only show a little vaginal bleeding, or a slight lower abdominal pain. The bleeding time can last for several days or weeks, and the blood volume is small. Once the vaginal bleeding increases, the abdominal pain is aggravated, the cervix has been expanded, and even when the fetal sac is blocked, the abortion is inevitable. If all the pregnancy is discharged, it is called complete abortion; only part of the pregnancy is discharged, and some of it remains in the uterine cavity, which is called incomplete abortion.
  • Salvia [alias] red root, Dahongpao, blood ginseng root, Xueshangen, red salvia, purple salvia miltiorrhiza. [Source] This product is the dry root and rhizome of Salvia miltiorrhiza. Excavate in the spring and autumn, remove the sediment and dry. [Sexual taste] bitter, slightly cold. [Return] to the heart, liver. [Indications] ⁇ ⁇ pain, blood circulation, clear heart and trouble. For irregular menstruation, menstrual dysmenorrhea, accumulation of symptoms, chest and abdomen tingling, sputum pain, sore swelling and pain, upset sleep; hepatosplenomegaly, angina. [Usage and dosage] Oral: Jiantang, 9 ⁇ 15g. [Note] It is not appropriate to Gourd is used together. [Excerpt] "Chinese Materia Medica”.
  • Fragrance [alias] drop true incense, wisteria incense, declining, rose pear mother. [Source] is the trunk and root of the leguminous arbor plant. [Sexual taste] Xin, warm. [Return to the heart] into the heart, liver. [Indications] Live blood: for chest pain, angina pectoris diarrhea: for turbid internal resistance, vomiting abdominal pain; hemostasis: for traumatic bleeding [Usage and dosage] Oral: Jiantang, 6 ⁇ 15g. [Excerpt] "Chinese Materia Medica”.
  • Dodder (alias) bean parasitic, no root grass, yellow silk, yellow silk vine, no vine, golden silk.
  • This product is a dry mature seed of the Convolvulaceae plant. When the autumn fruit matures, the plants are harvested, dried, and seeds are removed to remove impurities. [Sexual taste] sweet, warm. [Return] to the liver, kidney, spleen. ⁇ Indications ⁇ nourish liver and kidney, solidify and urinate, fetus, eyesight, diarrhea.
  • Mulberry parasitic [alias] ⁇ , Yumu, Wan Tong, mulberry parasitic, send debris, parasitic trees, parasitic grass, eucalyptus, ice powder tree, ⁇ .
  • [Source] It is a branch of the genus Mulberry, mistletoe, mulberry or mulberry.
  • [Indications] Liver and kidney, strong bones, rheumatism, fetus. For rheumatic pain, weak waist and knees, weak bones, uterine bleeding, pregnancy leakage, fetal movement; high blood pressure.
  • [Excerpt] "Chinese Materia Medica”.
  • Ejiao [alias] Fu Zhijiao, pot rubber, suede glue.
  • [Source] A rubber block made from the skin of the equine animal. The animal form is detailed.
  • [Excerpt] "Chinese Materia Medica”.
  • Guizhi Liu Gui. [Source] This product is a dry shoot of cinnamon of the family Polygonaceae. Harvested in spring and summer, remove leaves, dry, or slice and dry. [Sexual taste] Xin, Gan, warm. [Return] to the heart, lungs, bladder. [Indications] Sweat and muscle, Wentong meridian, help yang gas, flat flushing. For cold, cold, abdominal pain, cold blood stasis, joint pain, sipping, edema, heart palpitations, porpoise. [Usage and dosage] Oral: Jiantang, 3 ⁇ 10g. [Note] The syndrome of warm disease and yin deficiency and yang deficiency, blood test, and pregnant women should not take it. [Excerpt] "Chinese Materia Medica”.
  • Eclipta [alias] white lotus, taro, lotus grass, ink grass, ink tobacco, ink, pig tooth grass, Jinling grass, lotus seed grass, Eclipta prostrata, dry lotus seed, white flower grass, white flower daisy, ink dish , wild water impatiens, picking head black, dripping black, water impatiens grass, black ink grass, knot black, jumping fish grass, holiday head flower, around lotus, hot charcoal, blackhead grass, ancient city ink, water dry lotus , frozen grass, gold silk, ink grass.
  • Eclipta prostrata is the whole grass of the dicotyledonous plant Compositae. [Sexual taste] sweet, sour, cool.
  • the invention aims to provide a traditional Chinese medicine for treating habitual abortion, and to achieve a safe and effective cure for habitual abortion by selecting an appropriate medicinal material and its ratio.
  • the invention relates to a traditional Chinese medicine for treating habitual abortion, which is prepared by the following raw materials of weight ratio: 12 parts of Salvia miltiorrhiza, 10 parts of fragrance, 15 parts of dodder, 10 parts of sinensis, 10 20 parts, Ejiao 20, Guizhi 12, ⁇ 12, Eclipta 10, and Ligustrum lucidum.
  • the clinical manifestations are the same as those of general abortion, and it is also a stage of experiencing threatened abortion, inevitable abortion, incomplete or complete abortion. In the early stage, it can only show a little vaginal bleeding, or a slight lower abdominal pain. The bleeding time can last for several days or weeks, and the blood volume is small. Once the vaginal bleeding increases, the abdominal pain is aggravated, the cervix has been expanded, and even when the fetal sac is blocked, the abortion is inevitable. For example, all the gestational substances are completely aborted; only part of the pregnancy is discharged, and some of them remain in the uterine cavity, which is incomplete abortion.
  • the treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention 3 times a day.
  • the course of treatment is more than 2W after the longest gestation month of the previous abortion, and the fetus is still alive and the treatment is stopped.
  • the control group received oral life expectancy pills.
  • the 2W fetus survived after the longest gestational month of the previous abortion, and the treatment was stopped.
  • Clinical control re-pregnancy to full-term delivery after treatment (pregnancy success);
  • the medicine prepared by the invention can safely and effectively treat the habitual abortion and has the promotion value.

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Abstract

一种中药，原料药为：丹参12份、降香10份、菟丝子15份、续断10份、桑寄生10份、阿胶20份、桂枝12份、茯苓12份、墨旱莲10份、女贞子10份。该中药治疗习惯性流产。

Description

一种用于治疗习惯性流产的中药 技术领域
本发明涉及一种中药，具体涉及一种用于治疗习惯性流产的中药。
背景技术
凡妊娠不到20周，胎儿体重不足500克而中止者，称流产。习惯性流产是指连续发生3次以上者。其临床症状以阴道出血，阵发性腹痛为主。每次流产的临床过程和一次流产相同，只是常发生在同一妊娠月份。(1)遗传因素：染色体异常，核型异常的胚胎、胎儿大多伴有绒毛水肿及(或)绒毛细胞萎缩等胎盘结构异常，不能继续生长发育而自然淘汰。(2)母体因素：黄体功能不全；甲状腺功能低下，致胚胎发育不良；子宫病变；子宫颈闭锁不全乃晚期习惯性流产的主要原冈；胎盘内分泌不足，难以维持妊娠的继续发展；(3)父方因素活动的精于传递细菌，干扰精卵结合与着床。
习惯性流产的临床表现与一般流产相同，也是经历先兆流产、难免流产、不全或完全流产几个阶段。早期仅可表现为阴道少许出血，或有轻微下腹隐疼，出血时间可持续数天或数周，血量较少。一旦阴道出血增多，腹疼加重，检查宫颈口已有扩张，甚至可见胎囊堵塞颈口时，流产已不可避免。如妊娠物全部排出，称为完全流产；仅部分妊娠物排出，尚有部分残留在子宫腔内时，称为不全流产，需立即清宫处理。
中医学“滑胎”的病名，类似于现代医学的“反复性自然流产”。多数学者认为冲任损伤则肾虚无力系胞为该病之本，结合现代医学对该病病机的认识，治疗多以固肾为主，并取得较好疗效。然肾虚失却温煦或阴虚生热，热火灼精血或血滞不行而生血瘀则为该病之标。早在张仲景《金匮要略》中就提出了活血安胎、祛瘀安胎。
本发明所涉及药材研究现状如下：
丹参【别名】红根、大红袍、血参根、血山根、红丹参、紫丹参。【来源】本品为唇形科植物丹参的干燥根及根茎。春、秋二季采挖，除去泥沙，干燥。【性味】苦，微寒。【归经】归心、肝经。【功能主治】祛瘀止痛，活血通经，清心除烦。用于月经不调，经闭痛经，症瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。【用法用量】内服：煎汤，9～15g。【注意】不宜与 藜芦同用。【摘录】《中华本草》。
降香【别名】降真香、紫藤香、降真、花梨母。【来源】为豆科乔木植物降香檀的树干和根。【性味】辛，温。【归经】入心、肝经。【功能主治】活血行气：用于胸胁疼痛、心绞痛辟秽降逆：用于秽浊内阻，呕吐腹痛；止血：用于创伤出血【用法用量】内服：煎汤，6～15g。【摘录】《中华本草》。
菟丝子【别名】豆寄生、无根草、黄丝、黄丝藤、无娘藤、金黄丝子。【来源】本品为旋花科植物菟丝子的干燥成熟种子。秋季果实成熟时采收植株，晒干，打下种子，除去杂质。【性味】甘，温。【归经】归肝、肾、脾经。【功能主治】滋补肝肾，固精缩尿，安胎，明目，止泻。用于阳痿遗精，尿有余沥，遗尿尿频，腰膝酸软，目昏耳鸣，肾虚胎漏，胎动不安，脾肾虚泻；外治白癜风。【用法用量】内服：煎汤，6～12g。【注意】得酒良。薯蓣、松脂为之使，恶藋菌。肾家多火，强阳不痿者忌之，大便燥结者亦忌之。【摘录】《中华本草》。
续断【别名】川续断、和尚头、山萝卜。【来源】本品为川续断科植物川续断的干燥根。秋季采挖，除去根头及须根，用微火烘至半干，堆置“发汗”至内部变绿色时，再烘干。【性味】苦、辛，微温。【归经】归肝、肾经。【功能主治】补肝肾，强筋骨，续折伤，止崩漏。用于腰膝酸软，风湿痹痛，崩漏，胎漏，跌扑损伤。酒续断多用于风湿痹痛，跌扑损伤。盐续断多用于腰膝酸软。【用法用量】内服：煎汤，9～15g。【注意】初痢勿用，怒气郁者禁用。【摘录】《中华本草》。
桑寄生【别名】茑，寓木、宛童，桑上寄生、寄屑，寄生树，寄生草，茑木，冰粉树、蠹心宝。【来源】为桑寄生科植物槲寄生、桑寄生或毛叶桑寄生等的枝叶。【性味】苦甘，平。【归经】归肝、肾经。【功能主治】补肝肾，强筋骨，祛风湿，安胎元。用于风湿痹痛，腰膝酸软，筋骨无力，崩漏经多，妊娠漏血，胎动不安；高血压。【用法用量】内服：煎汤，9～15g。【摘录】《中华本草》。
阿胶【别名】傅致胶，盆覆胶，驴皮胶。【来源】为马科动物驴的皮去毛后熬制而成的胶块。动物形态详"驴肉"条。【性味】甘，平。【归经】入肺、肝、肾经。【功能主治】滋阴补血，安胎。治血虚，虚劳咳嗽，吐血，衄血、便血，妇女月经不调，崩中，胎漏。【用法用量】内服：煎汤，9～30g。【注意】 性粘腻，胃弱作呕吐者勿服；脾胃虚，食不消者亦忌之。【摘录】《中华本草》。
桂枝【别名】柳桂。【来源】本品为樟科植物肉桂的干燥嫩枝。春、夏二季采收，除去叶，晒干，或切片晒干。【性味】辛、甘，温。【归经】归心、肺、膀胱经。【功能主治】发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。【用法用量】内服：煎汤，3～10g。【注意】温热病及阴虚阳盛之证、血证、孕妇忌服。【摘录】《中华本草》。
茯苓【别名】茯苓个、茯苓皮、茯苓块、赤茯苓、白茯苓。【来源】本品为多孔菌科真菌茯苓的干燥菌核。多于7～9月采挖，挖出后除去泥沙，堆置“发汗”后，摊开晾至表面干燥，再“发汗”，反复数次至现皱纹、内部水分大部散失后，阴干，称为“茯苓个”；或将鲜茯苓按不同部位切制，阴干，分别称为“茯苓皮”及“茯苓块”。【性味】甘、淡，平。【归经】归心、肺、脾、肾经。【功能主治】利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。【用法用量】内服：煎汤，9～15g。【注意】虚寒精滑或气虚下陷者忌服。【摘录】《中华本草》。
墨旱莲【别名】白旱莲、猢狲头、莲草、墨斗草、墨烟草、墨菜、猪牙草、金陵草、莲子草、旱莲草、旱莲子、白花草、白花蟛蜞菊、墨记菜、野水凤仙、摘头乌、滴落乌、水凤仙草、黑墨草、节节乌、跳鱼草、假日头花仔、绕莲花、火炭草、黑头草、古城墨、水旱莲、冰冻草、金丝麻、墨汁草。【来源】旱莲草为双子叶植物药菊科植物鳢肠的全草。【性味】味甘、酸，性凉。【归经】归肾经、肝经。【功能主治】肝肾不足，眩晕耳鸣，视物昏花，腰膝酸软，发白齿摇，劳淋带浊，咯血，吐血，衄血，尿血，血痢，崩漏，外伤出血。【用法用量】内服：煎汤，3～10g。【摘录】《中华本草》。
女贞子【别名】爆格蚤、冬青子。【来源】本品为木犀科植物女贞的干燥成熟果实。冬季果实成熟时采收，除去枝叶，稍蒸或置沸水中略烫后，干燥；或直接干燥。【性味】甘、苦，凉。【归经】归肝、肾、经。【功能主治】滋补肝肾，明目乌发。用于眩晕耳鸣，腰膝酸软，须发早白，目暗不明。【用法用量】内服：煎汤，6-12g。【注意】脾胃虚寒泄泻及阳虚者忌服。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗习惯性流产的中药，通过选择合适的药材及其配比，达到安全有效治愈习惯性流产的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗习惯性流产的中药，其特征在于，它是由以下重量配比的原料药材制备而成：丹参12份、降香10份、菟丝子15份、续断10份、桑寄生10份、阿胶20份、桂枝12份、茯苓12份、墨旱莲10份、女贞子10份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院习惯性流产患者68例，随机分为治疗组32例与对照组36例，年龄26～43岁，病程3～9年，孕龄38～110天。2组性别、年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国习惯性流产临床专业会议的诊断标准：临床表现与一般流产相同，也是经历先兆流产、难免流产、不全或完全流产几个阶段。早期仅可表现为阴道少许出血，或有轻微下腹隐疼，出血时间可持续数天或数周，血量较少。一旦阴道出血增多，腹疼加重，检查宫颈口已有扩张，甚至可见胎囊堵塞颈口时，流产已不可避免。如妊娠物全部排出为完全流产；仅部分妊娠物排出，尚有部分残留在子宫腔内时为不全流产，需立即清宫处理。
2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日3次。疗程疗程以超过以往流产最长孕月以后2W胎儿仍存活，停止治疗。
对照组口服寿胎丸。疗程以超过以往流产最长孕月以后2W胎儿仍存活，停止治疗。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：治疗后再次妊娠至足月分娩者(妊娠成功)；
显效：再次妊娠达28W以上，B超显示宫内活胎；
有效：再次妊娠达20W以上，B超显示宫内活胎；
无效：再次妊娠达18W以下，B超显示宫内死胎。
3.2治疗结果见表1。
表1两组疗效比较
Figure PCTCN2017105514-appb-000001
可见，本发明制得的药物能够安全有效治疗习惯性流产，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：丹参12克、降香10克、菟丝子15克、续断10克、桑寄生10克、阿胶20克、桂枝12克、茯苓12克、墨旱莲10克、女贞子10克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗习惯性流产。口服，每日分早午晚三次服用。
实施例2
称取：丹参12克、降香10克、菟丝子15克、续断10克、桑寄生10克、阿胶20克、桂枝12克、茯苓12克、墨旱莲10克、女贞子10克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗习惯性流产。口服，每日分早午晚三次服用。
实施例3
称取：丹参12克、降香10克、菟丝子15克、续断10克、桑寄生10克、阿胶20克、桂枝12克、茯苓12克、墨旱莲10克、女贞子10克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗习惯性流产。口服，每日分早午晚三次服用。

Claims (4)

  1. 一种用于治疗习惯性流产的中药，其特征在于，它是由以下重量配比的原料药材制备而成：丹参12份、降香10份、菟丝子15份、续断10份、桑寄生10份、阿胶20份、桂枝12份、茯苓12份、墨旱莲10份、女贞子10份。
  2. 如权利要求1所述的用于治疗习惯性流产的中药，其特征在于，其制备方法为：称取：丹参12份、降香10份、菟丝子15份、续断10份、桑寄生10份、阿胶20份、桂枝12份、茯苓12份、墨旱莲10份、女贞子10份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
  3. 如权利要求1所述的用于治疗习惯性流产的中药，其特征在于，其制备方法为：称取：丹参12份、降香10份、菟丝子15份、续断10份、桑寄生10份、阿胶20份、桂枝12份、茯苓12份、墨旱莲10份、女贞子10份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
  4. 如权利要求1所述的用于治疗习惯性流产的中药，其特征在于，其制备方法为：称取：丹参12份、降香10份、菟丝子15份、续断10份、桑寄生10份、阿胶20份、桂枝12份、茯苓12份、墨旱莲10份、女贞子10份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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CN104771447A (zh) * 2015-04-16 2015-07-15 淄博夸克医药技术有限公司 一种用于治疗习惯性流产的中药
CN106075276A (zh) * 2016-08-29 2016-11-09 岳贵霞 一种用于治疗先兆流产的中药制剂及其制备方法

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CN104771447A (zh) * 2015-04-16 2015-07-15 淄博夸克医药技术有限公司 一种用于治疗习惯性流产的中药
CN106075276A (zh) * 2016-08-29 2016-11-09 岳贵霞 一种用于治疗先兆流产的中药制剂及其制备方法

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