WO2018227808A1 - 一种用于治疗子宫肌瘤的中药 - Google Patents

一种用于治疗子宫肌瘤的中药 Download PDF

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WO2018227808A1
WO2018227808A1 PCT/CN2017/103047 CN2017103047W WO2018227808A1 WO 2018227808 A1 WO2018227808 A1 WO 2018227808A1 CN 2017103047 W CN2017103047 W CN 2017103047W WO 2018227808 A1 WO2018227808 A1 WO 2018227808A1
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parts
peony
uterine fibroids
chinese medicine
traditional chinese
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PCT/CN2017/103047
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English (en)
French (fr)
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田丽华
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淄博夸克医药技术有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • the invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating uterine fibroids.
  • Uterine fibroids also known as uterine leiomyoma
  • uterine fibroids are the most common benign tumors of the female genitalia. More asymptomatic, a small number of vaginal bleeding, abdominal mass and compression symptoms. Pain can occur if pedicle torsion or other conditions occur. Multiple uterine fibroids are common.
  • Uterine fibroids are solid tumors that can grow in any part of the uterus, individually or in large size, and even grow in tens to hundreds of fibroids.
  • small fibroids are mostly spherical, but grow up or have multiple fibroids. When they fuse with each other, they become irregular shapes. The texture of fibroid tissue is harder than that of the uterus.
  • the fibroids have no capsule, and the fibroids are pressed around.
  • the muscle wall fibers form a pseudo-envelope, and the boundaries are clear. There is a loose reticular gap between the fibroids and the uterine muscle wall.
  • the pseudo-envelope exfoliates the fibroids.
  • the blood supply of the fibroids is mostly from the pseudo-envelope.
  • the surface of the fibroids is light, lustrous, and the cut surface is grayish white.
  • the spiral or braided structure is visible and the arrangement is dense.
  • the motherland medicine believes that the cause of uterine fibroids is mainly cold, cold is yin and evil, sexual stagnation is stagnation, cold sinisters are in the uterus, and qi and blood are dysfunctional, and blood stasis is formed by blood stasis, and it stops for a long time. Form a tumor.
  • the treatment is based on warm drugs, and the blood stasis is scattered. Just as the "Su Wen and Ci Suo" theory says: "The bloody person, the warmth and the cold, the weeping can't flow, and the temperature is gone.”
  • Guizhi Liu Gui. [Source] This product is a dry shoot of cinnamon of the family Polygonaceae. Harvested in spring and summer, remove leaves, dry, or slice and dry. [Sexual taste] Xin, Gan, warm. [Return] to the heart, lungs, bladder. [Indications] Sweat and muscle, Wentong meridian, help yang gas, flat flushing. For cold, cold, abdominal pain, cold blood stasis, joint pain, sipping, edema, heart palpitations, porpoise. [Usage and dosage] Oral: Jiantang, 3 ⁇ 10g. [Note] The syndrome of warm disease and yin deficiency and yang deficiency, blood test, and pregnant women should not take it. [Excerpt] "Chinese Materia Medica”.
  • Mudanpi [alias] Danpi, powdered paeonol, hibiscus, stripe, and Luoyang.
  • This product is the dried root bark of the peony of the Ranunculaceae plant. In the autumn, the roots are excavated, the fine roots are removed, the root bark is peeled off, and dried. [Sexual taste] bitter, spicy, slightly cold. [Return] to the heart, liver, kidney. [Indications] Clearing heat and cooling blood, promoting blood circulation and removing blood stasis. It is used for warming hair spots, vomiting blood and blood stasis, night heat and early cold, no sweat bone steaming, menstrual dysmenorrhea, swollen sores, falling and hurting. [Usage and dosage] Oral: Jiantang, 6-12g. [Note] Blood deficiency is cold, and pregnant women and menstruation are more cautious. [Excerpt] "Chinese Materia Medica”.
  • Peach kernel [alias] peach kernel.
  • This product is a dry mature seed of Rosaceae plant peach or mountain peach. After the fruit is ripe, it is harvested, the pulp and the core shell are removed, the seeds are taken out, and dried.
  • Pregnant women should use it with caution.
  • [Excerpt] "Chinese Materia Medica”.
  • Clematis [alias] iron feet Clematis, Hundred Roots, Tigers, Iron Broom [Source] This product is the Ranunculaceae plant Clematis cotton group Clematis (Hawthorn) or Northeast Clematis (Hei Wei Dry roots and rhizomes. Excavation in the fall, remove the sediment, and dry. [Sexual taste] Xin, salty, warm. [Return] to the bladder. [Indications] Hurricane dehumidification, Tongluo pain. For rheumatic pain, limb numbness, tendons and veins, unfavorable flexion and extension, osteophytes and throat. [Usage and dosage] Oral: Jiantang, 6 ⁇ 9g. [Note] Qi deficiency and blood weakness, no wind, cold and dampness are forbidden. [Excerpt] "Chinese Materia Medica”.
  • the invention aims to provide a traditional Chinese medicine for treating uterine fibroids, and achieve the purpose of safely and effectively curing uterine fibroids by selecting appropriate medicinal materials and their ratios.
  • a traditional Chinese medicine for treating uterine fibroids which is prepared from the following raw materials of weight ratio: 15 parts of cassia twig, 15 parts of medlar, 12 parts of peony skin, 12 parts of red peony, and 10 pieces of peach kernel 15 parts, 15 parts of persimmon, 15 parts of solitary, 15 parts of white peony, 10 parts of clematis.
  • the treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention 3 times a day.
  • the course of treatment is 6 months.
  • the control group received oral mifepristone tablets at 12.5 mg/day.
  • the course of treatment is 6 months.
  • the medicine prepared by the invention can safely and effectively treat uterine fibroids, and has the promotion value.

Abstract

一种用于治疗子宫肌瘤的中药，它是由下列重量份的原料药制成的：桂枝15、茯苓15、牡丹皮12、赤芍12、桃仁10、透骨草15、独活15、白芷15、和威灵仙10。

Description

一种用于治疗子宫肌瘤的中药 技术领域
本发明涉及一种中药，具体涉及一种用于治疗子宫肌瘤的中药。
背景技术
子宫肌瘤又称子宫平滑肌瘤，是女性生殖器最常见的一种良性肿瘤。多无症状，少数表现为阴道出血，腹部触及肿物以及压迫症状等。如发生蒂扭转或其他情况时可引起疼痛。以多发性子宫肌瘤常见。
子宫肌瘤是实性肿瘤，可单个或多个生长在子宫任何部位，大小悬殊，甚至几十至百个肌瘤同时生长，一般小肌瘤多为圆球形，但长大或多个肌瘤互相融合时，则成为不规则的形状，肌瘤组织质地较子宫为硬，在直视下，从子宫外极易触摸到子宫肌瘤存在的部位，肌瘤并无包膜，肌瘤压迫周围的肌壁纤维而形成假包膜，二者界限分明，肌瘤与子宫肌壁间有一层疏松的网状间隙，切开肌壁，肌瘤多会从肌壁间跃出，且极易从假包膜将肌瘤剥出，肌瘤血液供应多来自假包膜，肌瘤表面色淡，光泽，切面呈灰白色，可见旋涡状或编织状结构，排列致密。
祖国医学认为：子宫肌瘤的病因以寒为主，寒为阴邪，性主凝滞，寒邪客于子宫，冲任气血失调，经脉气血不畅形成瘀血，瘀停日久，积而成瘤。治疗以温性药物为主，活血祛瘀散结，正如《素问·词经论》言：“血气者，喜温而恶寒则泣不能流，温则消而去之”。
本发明所涉及药材研究现状如下：
桂枝【别名】柳桂。【来源】本品为樟科植物肉桂的干燥嫩枝。春、夏二季采收，除去叶，晒干，或切片晒干。【性味】辛、甘，温。【归经】归心、肺、膀胱经。【功能主治】发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。【用法用量】内服：煎汤，3～10g。【注意】温热病及阴虚阳盛之证、血证、孕妇忌服。【摘录】《中华本草》。
茯苓【别名】茯苓个、茯苓皮、茯苓块、赤茯苓、白茯苓。【来源】本品为多孔菌科真菌茯苓的干燥菌核。多于7～9月采挖，挖出后除去泥沙，堆置“发汗”后，摊开晾至表面干燥，再“发汗”，反复数次至现皱纹、内部水分大部散失后，阴干，称为“茯苓个”；或将鲜茯苓按不同部位切制，阴干，分别 称为“茯苓皮”及“茯苓块”。【性味】甘、淡，平。【归经】归心、肺、脾、肾经。【功能主治】利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。【用法用量】内服：煎汤，9～15g。【注意】虚寒精滑或气虚下陷者忌服。【摘录】《中华本草》。
牡丹皮【别名】丹皮、粉丹皮、木芍药、条丹皮、洛阳花。【来源】本品为毛茛科植物牡丹的干燥根皮。秋季采挖根部，除去细根，剥取根皮，晒干。【性味】苦、辛，微寒。【归经】归心、肝、肾经。【功能主治】清热凉血，活血化瘀。用于温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，痈肿疮毒，跌扑伤痛。【用法用量】内服：煎汤，6-12g。【注意】血虚有寒，孕妇及月经过多者慎服。【摘录】《中华本草》。
赤芍【别名】木芍药、红芍药、赤芍、臭牡丹根。【来源】中药赤芍为毛茛科多年生草本植物芍药和川赤芍的根。【性味】苦，微寒。【归经】归肝经。【功能主治】行瘀、止痛、凉血、消肿。主治：治瘀滞经闭、疝瘕积聚、腹痛、胁痛、衄血、血痢、肠风下血、目赤、痈肿、跌扑损伤。【用法用量】内服：煎汤，6～15g。【注意】赤芍性寒，虚寒性痛经、经闭忌用。【摘录】《中华本草》。
桃仁【别名】桃核仁。【来源】本品为蔷薇科植物桃或山桃的干燥成熟种子。果实成熟后采收，除去果肉及核壳，取出种子，晒干。【性味】苦、甘，平。【归经】归心、肝、大肠经。【功能主治】活血祛瘀，润肠通便。用于经闭，痛经，癓瘕痞块，跌扑损伤，肠燥便秘。【用法用量】内服：煎汤，4.5～9g。【注意】孕妇慎用。【摘录】《中华本草》。
透骨草【别名】【来源】大戟科地构叶属植物地构叶、凤仙花科草本植物凤仙花、紫葳科角蒿属植物角蒿、豆科野豌豆属植物山野豌豆的全草和杜鹃花科白珠树属植物滇白珠的全株。夏秋采。【性味】辛、苦，温。【归经】归肝、肾经。【功能主治】祛风除湿，解毒止痛。用于风湿关节痛；外用治疮疡肿毒。【用法用量】内服：煎汤，3～9g。【注意】孕妇忌服。【摘录】《中华本草》。
独活【别名】香独活、肉独活、川独活、资丘独活。【来源】本品为伞形科植物重齿毛当归的干燥根。春初苗刚发芽或秋末茎叶枯萎时采挖，除去须根及泥沙，烘至半干，堆置2～3天，发软后再烘至全干。【性味】辛、苦，微温。【归经】归肾、膀胱经。【功能主治】祛风除湿，通痹止痛。用于风寒湿痹，腰 膝疼痛，少阴伏风头痛。【用法用量】内服：煎汤，3-9g。【注意】阴虚血燥者慎服。【摘录】《中华本草》。
白芷【别名】薛、芷，芳香，苻蓠、泽芬，白茝，香白芷。【来源】本品为伞型科植物白芷或杭白芷的干燥根。夏、秋间叶黄时采挖，除去须根及泥沙，晒干或低温干燥。【性味】辛，温。【归经】归胃、大肠、肺经。【功能主治】散风除湿，通窍止痛，消肿排脓。用于感冒头痛，眉棱骨痛，鼻塞，鼻渊，牙痛，白带，疮疡肿痛。【用法用量】内服：煎汤，3～9g。【注意】阴虚血热者忌服。当归为之使。恶旋覆花。【摘录】《中华本草》。
威灵仙【别名】铁脚威灵仙、百条根、老虎须、铁扫帚【来源】本品为毛茛科植物威灵仙棉团铁线莲(山蓼)或东北铁线莲(黑薇)的干燥根及根茎。秋季采挖，除去泥沙，晒干。【性味】辛、咸，温。【归经】归膀胱经。【功能主治】祛风除湿，通络止痛。用于风湿痹痛，肢体麻木，筋脉拘挛，屈伸不利，骨哽咽喉。【用法用量】内服：煎汤，6～9g。【注意】气虚血弱，无风寒湿邪者忌服。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗子宫肌瘤的中药，通过选择合适的药材及其配比，达到安全有效治愈子宫肌瘤的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗子宫肌瘤的中药，其特征在于，它是由以下重量配比的原料药材制备而成：桂枝15份、茯苓15份、牡丹皮12份、赤芍12份、桃仁10份、透骨草15份、独活15份、白芷15份、威灵仙10份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院子宫肌瘤患者66例，随机分为治疗组35例与对照组31例，年龄27～52岁，平均年龄43.9岁，病程10.8月。2组年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国子宫肌瘤临床专业会议的诊断标准：(1)月经量增多，经期延长。(2)下腹部包块。(3)尿频、排尿困难或大便秘结等。(4)阴道断续流血或脓血性白 带。(5)妇科检查可发现子宫增大或可触到肌瘤结节。(6)B超检查可显示出肌瘤的图像。(7)疼痛：一般患者无腹痛，常有下腹坠胀、腰背酸痛等，当浆膜下肌瘤蒂扭转时，可出现急性腹痛肌瘤红色变时，腹痛剧烈且伴发热。
2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日3次。疗程6个月。
对照组口服米非司酮片，12.5mg/天。疗程6个月。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：临床症状消失、超声检查肌瘤消失；
有效：临床症状有所改善、超声检查肌瘤体积较治疗后缩小；
无效：临床症状无改善、超声检查肌瘤体积较治疗后增大；
3.2治疗结果见表1。
表1两组疗效比较
Figure PCTCN2017103047-appb-000001
可见，本发明制得的药物能够安全有效治疗子宫肌瘤，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：桂枝15克、茯苓15克、牡丹皮12克、赤芍12克、桃仁10克、透骨草15克、独活15克、白芷15克、威灵仙10克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗子宫肌瘤。口服，每日分早午晚三次服用。
实施例2
称取：桂枝15克、茯苓15克、牡丹皮12克、赤芍12克、桃仁10克、透骨草 15克、独活15克、白芷15克、威灵仙10克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗子宫肌瘤。口服，每日分早午晚三次服用。
实施例3
称取：桂枝15克、茯苓15克、牡丹皮12克、赤芍12克、桃仁10克、透骨草15克、独活15克、白芷15克、威灵仙10克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗子宫肌瘤。口服，每日分早午晚三次服用。

Claims (4)

  1. 一种用于治疗子宫肌瘤的中药，其特征在于，它是由以下重量配比的原料药材制备而成：桂枝15份、茯苓15份、牡丹皮12份、赤芍12份、桃仁10份、透骨草15份、独活15份、白芷15份、威灵仙10份。
  2. 如权利要求1所述的用于治疗子宫肌瘤的中药，其特征在于，其制备方法为：称取：桂枝15份、茯苓15份、牡丹皮12份、赤芍12份、桃仁10份、透骨草15份、独活15份、白芷15份、威灵仙10份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
  3. 如权利要求1所述的用于治疗子宫肌瘤的中药，其特征在于，其制备方法为：称取：桂枝15份、茯苓15份、牡丹皮12份、赤芍12份、桃仁10份、透骨草15份、独活15份、白芷15份、威灵仙10份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
  4. 如权利要求1所述的用于治疗子宫肌瘤的中药，其特征在于，其制备方法为：称取：桂枝15份、茯苓15份、牡丹皮12份、赤芍12份、桃仁10份、透骨草15份、独活15份、白芷15份、威灵仙10份加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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CN104800319A (zh) * 2015-04-14 2015-07-29 淄博夸克医药技术有限公司 一种用于治疗子宫肌瘤的中药
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CN104800319A (zh) * 2015-04-14 2015-07-29 淄博夸克医药技术有限公司 一种用于治疗子宫肌瘤的中药
CN106177026A (zh) * 2016-08-18 2016-12-07 上海典实医疗科技有限公司 桂枝茯苓丸及其制备方法

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