WO2018233112A1

WO2018233112A1 - Traditional chinese medicine for treating diarrhoea

Info

Publication number: WO2018233112A1
Application number: PCT/CN2017/103321
Authority: WO
Inventors: 田丽华
Original assignee: 淄博夸克医药技术有限公司
Priority date: 2017-06-18
Filing date: 2017-09-26
Publication date: 2018-12-27
Also published as: CN109125512A

Abstract

Disclosed is a traditional Chinese medicine for treating diarrhoea, prepared from the following raw materials in parts by weight: 12 parts of nutmeg, 15 parts of malaytea scurfpea fruit, 15 parts of medicinal evodia fruit, 10 parts of Chinese magnolia-vine fruit, 12 parts of shrub chaste tree fruit, 9 parts of divaricate saposhnikovia root, 9 parts of Chinese lovage and 6 parts of spine date seed. The traditional Chinese medicine can be prepared into a decoction, powders and capsules after decocting with water and combining the filtrate.

Description

Traditional Chinese medicine for treating diarrhea

Technical field

The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating diarrhea.

Background technique

Diarrhea is a common symptom, commonly known as "diarrhea", which means that the frequency of bowel movements is significantly higher than the frequency of usual habits, the faecal is thin, the water is increased, the daily defecation is more than 200g, or contains undigested food or pus and mucus. Diarrhea is often accompanied by symptoms such as urgency of bowel movements, anal discomfort, and incontinence. Diarrhea is divided into acute and chronic. The incidence of acute diarrhea is acute, and the course of disease is within 2 to 3 weeks. Chronic diarrhea refers to recurrent diarrhea with a course of disease of more than two months or intermittent within 2 to 4 weeks.

Traditional Chinese medicine refers to diarrhea as diarrhea, venting to leakage, thin stools, diarrhea for urgency, and direct manure. Acute diarrhea is called diarrhea, and chronic diarrhea is called chronic diarrhea. Diarrhea means that the number of bowel movements is increased, the stool is thin, or the valley is not finished, and even the water is discharged. Chinese medicine believes that the cause of diarrhea is more complicated, but it is always inseparable from the spleen and stomach function. In terms of external causes, this disease is caused by the invasion of the spleen and stomach by dampness, which is called “wet wins and suffocates”; in terms of internal factors, it is associated with diet, spleen and stomach weakness, life-threatening fever and emotional disorders, among which spleen deficiency The relationship is the closest, due to spleen dysfunction, water and wet endogenous diarrhea. The so-called "the root of diarrhea, all because of the spleen and stomach", so the spleen and dampness is the key to the treatment of this disease. Traditional Chinese medicine has rich experience and good curative effect in the treatment of diarrhea by syndrome differentiation. In modern medicine, when diarrhea occurs due to functional or organic diseases of the digestive organs, such as acute and chronic enteritis, intestinal tuberculosis, irritable bowel disease, intestinal dysfunction, etc., the method of traditional Chinese medicine can also be used for syndrome differentiation.

The research status of the medicinal materials involved in the present invention is as follows:

Nutmeg [alias] 蔻, coix seed, fake numb tree, dice. [Source] This product is a dry near mature seed of the ginger family soybean meal. Harvested in summer and autumn, sun-dried to 90% dry, or slightly hot with water, sun-dried to semi-dry, remove the peel, take out the seed group, and dry. [Sexual taste] Xin, warm. [Return to the spleen] stomach, stomach. [Indications] Dampness and spleen, warm stomach and vomiting. For cold and internal resistance, abdominal pain and full of cold pain, belching and vomiting, do not think about diet. [Usage and dosage] Oral: Jiantang, 3 ~ 12g. [Excerpt] "Chinese Materia Medica".

Buguzhi [alias] Hu Zizi, Po Guzhi, broken paper, bones, black son, Hu, son, Ji Guzi. [Source] This product is a dry mature fruit of leguminous psoralen. When the fruit is ripe in autumn, the fruit is harvested, dried, and the fruit is removed to remove impurities. [Sexual taste] Xin, bitter, warm. [Return] to the kidney, spleen. [Indications] Wenshen helps yang, gas, and diarrhea. For impotence and nocturnal emission, frequent urination, low back pain, kidney Virtual asthma, five more diarrhea; topical treatment of vitiligo, alopecia areata. [Usage and dosage] Oral: Jiantang, 6 ~ 9g. [Note] Any illness, yin and anger, dreams, blood in the urine, urinating short sputum and sputum dry, dry stool, dry heat, thirst, fire, redness, hunger, phlegm, dampness and heat, so that the bones are weak, all Not suitable for service. [Excerpt] "Chinese Materia Medica".

Wu Hao [alias] Wu Hao, tea spicy, spicy, stinky, Wu pepper, stinky bubble. [Source] This product is a dry, near-mature fruit of the genus Eucalyptus, Wujing, Shihu or Shuwu. When the fruit has not been cracked from August to November, the fruit branches are cut, dried or dried at low temperature to remove impurities such as branches, leaves and fruit stems. [Sexual taste] Xin, bitter, hot; [Return] to the liver, spleen, stomach, kidney. [Indications] Dispelling cold and relieving pain, reducing vomiting, helping yang to stop diarrhea. For phlegm headache, cold and abdominal pain, cold and wet athlete's foot, abdominal pain, abdominal pain, vomiting and sour, five more diarrhea, external treatment of mouth sores; high blood pressure. [Usage and Dosage] Oral: Jiantang, 1.5 ~ 4.5g. [Note] Yin Huowang is not allowed to take it. [Excerpt] "Chinese Materia Medica".

Schisandra [alias] 菋, 荎蕏, Xuanhe, will, five plums, North Schisandra, Liao Wuzi. [Source] This product is a dry mature fruit of the Magnoliaceae Schisandra or Huazhong Schisandra. The former is called "Northern Schisandra", and the latter is called "Southern Schisandra." When the autumn fruit is ripe, it is picked, dried or steamed, and dried to remove the fruit stems and impurities. [Sexual taste] sour, sweet, warm. [Return] to the lungs, heart, kidney. [Functions and Indications] Convergence and solidification, benefit Qi and fluid, and replenish kidney and Ningxin. For long-term phlegm and asthma, dreams slippery essence, enuresis and frequent urination, long-term diarrhea, spontaneous sweating, night sweats, Tianjin wounds thirst, short qi deficiency, internal heat and thirst, palpitations and insomnia. [Usage and dosage] Oral: Jiantang, 3 ~ 12g. [Note] There is an evil outside, there is real heat inside, or the beginning of cough, the first occurrence of pityria is not allowed. [Excerpt] "Chinese Materia Medica".

Vine wattle [alias] white back fungus, white back Yang, water scorpion, white cloth Jing. [Source] This product is a dry mature fruit of the genus Verbena or the vine. When the autumn fruit matures, it is harvested, impurities are removed, and dried. [Sexual taste] Xin, bitter, slightly cold. [Return] to the bladder, liver, stomach. [Indications] evacuate wind and heat, clear leader. It is used for wind-heat cold headache, swelling and pain of the gums, red eyes and tears, dark eyes and dizziness. [Usage and dosage] Oral: Jiantang, 5 ~ 9g. [Note] 痿痹痿痹挛不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不不[Excerpt] "Chinese Materia Medica".

Windproof [alias] gongs, fennel, fennel, hundred branches, 闾 root, hundred 蜚, screen, wind meat. [Source] This product is a dry root of the Umbelliferae plant. In the spring and autumn, the roots of the unscented stems are excavated, the roots and sediment are removed, and dried. [Sexual taste] Xin, Gan, warm. [Return] to the bladder, liver, spleen. Gong Can attend] to solve the hurricane, win the wet, stop sputum. For cold headache, rheumatism, rubella, tetanus, tetanus. [Usage and Dosage] Oral: Jiantang, 4.5 ~ 10g. [Note] It is not appropriate to clear stools and have wet stools. [Excerpt] "Chinese Materia Medica".

Sakamoto [alias] 藁茇, ghost Qing, Di Xin, Hawthorn, Wei Xiang, micro stem, seesaw. [Source] is the rhizome and root of the Umbelliferae plant or the Liao sui, the scorpion. Roots and roots are excavated in spring and autumn, stems and leaves are removed, dried or dried. [Sexual taste] Xin, warm. [Return] The sun's bladder and the hand's small intestine. [Functions and Indications] scattered wind and cold dampness. Treatment of cold headache, phlegm pain, cold and damp abdominal pain, diarrhea, phlegm, phlegm. [Usage and dosage] Oral: Jiantang, 3 ~ 9g. [Note] Warm headache, fever, thirst or bone pain, and typhoid fever in spring and summer, Yang syndrome headache, postpartum blood deficiency, fire and headache, are not suitable for service. [Excerpt] "Chinese Materia Medica".

Suanzaoren [alias] mountain jujube, jujube. [Source] This product is a dry mature seed of the jujube plant. Mature fruit is harvested at the end of autumn and winter, the flesh and core shell are removed, the seeds are collected and dried. [Sexual taste] sweet, sour, flat. [Return to the classics] to the liver, gallbladder, heart. [Indications] Liver, Ningxin, sweat, Shengjin. It is used for virtual annoyance, horror and dreams, physical and sweaty, and thirsty for Tianjin. [Usage and dosage] Oral: Jiantang, 9 ~ 15g. [Note] Those who have liver, gallbladder, and spleen should not use it because of its convergence. [Excerpt] "Chinese Materia Medica".

Summary of the invention

The invention aims to provide a traditional Chinese medicine for treating diarrhea, and achieve the purpose of safely and effectively curing diarrhea by selecting an appropriate medicinal material and its ratio.

In order to achieve the above object, the present invention adopts the following technical solutions:

A traditional Chinese medicine for treating diarrhea, which is prepared from the following raw materials of weight ratio: 12 parts of nutmeg, 15 parts of psoralen, 15 parts of sorghum, 10 parts of schisandra, and 12 vines Serve, windproof 9 parts, sputum 9 parts, 6 jujube kernels.

The beneficial effects of the present invention will be described below in conjunction with clinical experimental data:

1. General information

The inventors collected 98 patients with outpatient and inpatient diarrhea from October 2012 to October 2013. They were randomly divided into treatment group (n=50) and control group (n=48). The course of disease was within 3 days. There were no significant differences in gender, age and duration of disease between the two groups, which were comparable.

Diagnostic criteria

According to the diagnostic criteria of the National Diarrhea Clinical Professional Conference: (1). The stool is thin or as watery, the number of times increases. May be associated with abdominal distension, abdominal pain and other symptoms. (2). Acute diarrhea is sudden onset, short course of disease, and may be accompanied by aversion to cold and fever. (3). Chronic long-term diarrhea is slow onset, long course of disease, repeated attacks, light and heavy. (4). Improper diet, induced by cold or emotional changes. (5). A small amount of red blood cells can be seen in the stool, and the pathogenic bacteria in the stool culture are positive or negative. (6). X-ray barium enema or fiber colonoscopy should be performed if necessary.

2, test methods

2.1 treatment methods

The treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention 3 times a day. The treatment lasts for one month.

The control group was orally administered with citrate protein and aluminum hydroxide gel for 3 times/day. The treatment lasts for one month.

3, efficacy standards and treatment results

3.1 efficacy standard

Clinical control: After 3 days of treatment, the clinical symptoms disappeared, the stool was formed, the expression was normal, and the spirit was refreshed;

Effective: The condition returns to normal within 5 days;

Invalid: The condition is not significantly improved within 5 days, and treatment continues.

3.2 The treatment results are shown in Table 1.

Table 1 Comparison of the two groups

It can be seen that the medicine prepared by the invention can safely and effectively treat diarrhea and has the promotion value.

Detailed ways

For a better understanding and implementation of the present invention, the invention will be further described in conjunction with the specific embodiments.

Example 1

Weighing: 12 grams of nutmeg, 15 grams of psoralen, 15 grams of sorghum, 10 grams of Schisandra, 12 grams of vine, 12 grams of wind, 9 grams of medlar, 6 grams of jujube, and 8 times of water, boiled 1.5 hours, filtration; filter residue plus 6 times the amount of water, boiling for 1 hour, filtration; the filtrate was combined and concentrated to 120 grams, which is a decoction that meets the daily dosage of normal adults.

For the treatment of diarrhea. Oral, taken three times a day, morning, evening and evening.

Example 2

Weighing: 12 grams of nutmeg, 15 grams of psoralen, 15 grams of Wusong, 10 grams of Schisandra, 12 grams of vine, 9 grams of wind, 9 grams of sputum, 6 grams of jujube, plus 10 times the amount of water, boiling 2 hours, filtration; filter residue plus 8 times the amount of water, boiling for 1.5 hours, filtration; the filtrate is combined, concentrated, dried, and packaged, that is, a powder that meets the daily dosage of normal adults.

Example 3

Weighing: 12 grams of nutmeg, 15 grams of psoralen, 15 grams of Wusong, 10 grams of Schisandra, 12 grams of vine, 9 grams of wind, 9 grams of medlar, 6 grams of jujube kernels; add 6 times the amount of water, boil 3 times, each time of boiling for 1 hour, combined with decoction, concentrated, dried, and filled into the capsule shell, which is a capsule that meets the daily dosage of normal adults.

Claims

A traditional Chinese medicine for treating diarrhea, which is prepared from the following raw materials of weight ratio: 12 parts of nutmeg, 15 parts of psoralen, 15 parts of sorghum, 10 parts of schisandra, and 12 vines Serve, windproof 9 parts, sputum 9 parts, 6 jujube kernels.
The traditional Chinese medicine for treating diarrhea according to claim 1, wherein the preparation method comprises the following steps: weighing: 12 parts of nutmeg, 15 parts of psoralen, 15 parts of sorghum, 10 parts of schisandra, and 12 parts of vine. 9 parts of windproof, 9 parts of medlar, 6 parts of jujube seed; add 8 times of water, decoct for 1.5 hours, filter; add 6 times of water to filter residue, decoct for 1 hour, filter; combine filtrate, concentrate to 120 parts, That is, decoction is obtained; the above parts all mean parts by weight.
The traditional Chinese medicine for treating diarrhea according to claim 1, wherein the preparation method comprises the following steps: weighing: 12 parts of nutmeg, 15 parts of psoralen, 15 parts of sorghum, 10 parts of schisandra, and 12 parts of vine. 9 parts of windproof, 9 parts of medlar, 6 parts of jujube seed; add 10 times of water, boil for 2 hours, filter; filter residue with 8 times water, decoct for 1.5 hours, filter; combine filtrate, concentrate, dry, package , that is, a powder; the above parts are all parts by weight.
The traditional Chinese medicine for treating diarrhea according to claim 1, wherein the preparation method comprises the following steps: weighing: 12 parts of nutmeg, 15 parts of psoralen, 15 parts of sorghum, 10 parts of schisandra, and 12 parts of vine. 9 parts of windproof, 9 parts of medlar, 6 parts of jujube seed; add 6 times of water, decoct 3 times, boil for 1 hour each time, combine decoction, concentrate, dry, and fill into capsule shell, get capsule The above ingredients are all parts by weight.