CN110585361A - Radix ophiopogonis and honey-fried licorice root traditional Chinese medicine teabag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid - Google Patents

Radix ophiopogonis and honey-fried licorice root traditional Chinese medicine teabag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid Download PDF

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CN110585361A
CN110585361A CN201911003972.5A CN201911003972A CN110585361A CN 110585361 A CN110585361 A CN 110585361A CN 201911003972 A CN201911003972 A CN 201911003972A CN 110585361 A CN110585361 A CN 110585361A
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root
chinese medicine
traditional chinese
honey
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王雪
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Harbin Yingri Biomedical Technology Co Ltd
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Harbin Yingri Biomedical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23FCOFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00Tea; Tea substitutes; Preparations thereof
    • A23F3/34Tea substitutes, e.g. matè; Extracts or infusions thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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Abstract

The invention discloses a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine bag tea for tonifying qi, recovering pulse, nourishing yin and promoting fluid production, which is prepared from radix ophiopogonis, honey-fried licorice root, euonymus fortunei, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax bunge, aleppo avens, radix asparagi, prepared rehmannia root, mulberry, dendrobium, trichosanthes root, kudzuvine root, roughhaired holly root, fructus terminaliae immaturus, reed rhizome, Chinese pulsatilla flower and the like, and the product has the effects of tonifying qi, recovering pulse, nourishing yin and promoting fluid production, improves the immunity of the organism, and can effectively treat diseases such as deficiency of qi and blood, dizziness, insomnia, amnesia; compared with Chinese patent medicine, has the advantages of wide treatment range, quick response, simple preparation, convenient eating, rich nutrition, easy absorption and the like.

Description

Radix ophiopogonis and honey-fried licorice root traditional Chinese medicine teabag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid
Technical Field
The invention relates to the field of health-care beverages, in particular to a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid.
Background
With the development of society, the living pressure of people is higher and higher, the living rhythm is faster and faster, the dietary structure is unreasonable, more and more people have sub-health state, and the long-term taking of medicines is easy to generate dependence and is not beneficial to the body. Particularly, in recent years, data in the general survey of the population health in China and various policy documents issued by China all show that the development of the health industry is supported more in the future, along with the attention of people on health-care food, drink tea with the health-care function becomes more and more daily drinks for people, the development degree of the tea bag is higher and higher, various tea bags made of Chinese herbal medicines as main raw materials exist in the existing market, and the market prospect of the tea bag is particularly considerable. The bagged tea is prepared by extracting folium Camelliae sinensis, coarse powder of Chinese medicinal materials or part of the Chinese medicinal materials, drying, and packaging. Also called as Chinese medicinal tea bag. When in use, the tea is placed in a tea cup with a cover and is brewed with boiled water to be drunk as the next generation tea, so the tea is called as the tea preparation. The tea is prepared by processing and pulverizing tea or Chinese medicinal materials into coarse powder, or extracting medicinal juice, mixing with other medicinal materials, and packaging in special filter paper bag for drinking. The traditional Chinese medicine tea bag is a new formulation developed on the basis of ancient powder boiling and drinking preparations in China, has the effects of cleaning viscera, regulating yin and yang, removing evil and evil, caring skin, benefiting qi and strength, assisting exhaustion and the like, and is quick to absorb and act. The bagged steeping drug has small volume, large crude drug content, fast dissolution, convenient taking and drug saving, keeps the characteristics and advantages of the traditional decoction, is closer to the dietary habits of Chinese people, is an ideal improved preparation of the traditional decoction, and becomes a well-known and loved medicine preparation of the public.
The tea occupies a place in the traditional culture of magnificent in China, and the tea, including the medicinal tea, plays an important role in the life and medical care of people in China. The medicinal tea is also called tea, and is an important component in a traditional Chinese medicine treasury, namely tea or Chinese herbal medicines (single or compound) are brewed and decocted and then drunk like daily tea drinking to prevent and treat diseases. The earliest recorded herbal tea prescription is Guangye of Zhangtong at three kingdoms, and recorded in Shennong herbal Jing Jizhu of ShangGechu of Shangqu and Qianjin Yao of Sun Simiao in Tang Dynasty until Wang 28952foreign secret, the preparation and administration methods of some herbal tea are described in detail, and since then, new herbal tea prescriptions emerge in large numbers, no matter the dietary spectrum of court and the smart herbal tea prescriptions are visible. There is no exact history record about the origin of the tea bag, and only the british daily post press reports 6, 12 days in 2008, which means that the tea bag has a hundred years history. It was reported that in 6 months 1908, the new york tea businessman thomas sarlivin, usa wanted to drive down business costs, and therefore decided to load a small sample of tea leaves into a small silk bag for sending to potential customers for testing. Upon receipt of these strange pouches, the suspected customers could only attempt to soak them in a cup of boiling water without going. The earliest tea bags in the world were produced as such, however, the tea bags have undergone various changes since birth. Firstly, the Shaliwent uses tissue paper to replace silk to make tea bags. Subsequently, in 1930, Wellman Hellman pine patented heat-sealed paper tea bags. In 1953, the british taitley tea company started mass production of tea bags and continued to improve the bag design. In 1964, the quality of tea bags is improved more carefully, which makes the tea bags more popular. In 1989, the Taiteli tea company introduced round tea bags with a standard square tea bag design. In a few years, the tea company of teteli pushed out tea bags with a drawstring, and there were 30 different kinds of tea in the tea bags. In addition, pyramid-shaped tea bags and nylon tea bags successively enter the great britain market. From the statistical results, it was shown that the british consumed 13 billion cups of teabag each day. William golmann, england tea committee: "every day, 40% of the liquid taken by the English people every day is tea water, and most of the liquid is bagged tea. "Japan also carried out the research of the traditional Chinese medicine bag-steeping drug in the 70 th of the 20 th century, and the research and application of the traditional Chinese medicine bag-steeping drug in the 80 th of the 20 th century are started domestically, especially the preparation process, the leaching rate, the clinical application, the pharmacological action and other aspects of the traditional Chinese medicine bag-steeping drug are researched in a large amount, and a series of happy achievements are obtained. For example, in the drug Standard of Ministry of health of the people's republic of China, there are many varieties of Chinese medicinal tea bags such as Chuan Xiong tea bag infusion, blood pressure lowering tea bag, eight-treasure tea bag, etc.; in addition, bagged tea (also called bagged tea) is also collected under the item of IT tea in the appendix of the first edition of Chinese pharmacopoeia 2005, and the method and standard for checking the items such as water content, content difference and microorganism limit are specified. In a word, the traditional Chinese medicine tea has a long history as one of the traditional Chinese medicine formulations in China, and the traditional Chinese medicine tea bag serving as a new traditional Chinese medicine formulation appears in China only in the last 80 th century. Although the application history of the traditional Chinese medicine tea bag is not long, the traditional Chinese medicine tea bag has long-term development in the research of nearly 30 years, people demonstrate the feasibility, reliability and controllability of the traditional Chinese medicine tea bag from different angles, and carry out a lot of work on the aspects of preparation process, quality standard and the like, and the effect is very good. The main points are as follows: in the aspect of extraction process, modern most advanced technologies such as ultrasonic waves and the like are adopted for extraction, an orthogonal test method is adopted for optimizing the optimal preparation process and the like; the preparation method is more excellent in quality standard research, firstly, the general rule of the preparation of the traditional Chinese medicine tea bag is established in Chinese pharmacopoeia (1995 edition), and secondly, the modern latest qualitative and quantitative control technology is applied to the qualitative and quantitative research of the traditional Chinese medicine tea bag, for example, the content reports of the notoginsenoside R1, the ginsenoside Rg1 and the ginsenoside Rb1 in the Kangerxin tea bag are determined by adopting a high performance liquid chromatography evaporative light scattering detection method. Certainly, as a new formulation of Chinese patent medicine, the tea bag of traditional Chinese medicine has many problems to be perfected and solved, but we believe that with the development and application of new technology, new equipment of new technology, the preparation technology, quality standard and other aspects of the tea bag of traditional Chinese medicine will be studied more deeply, and some problems encountered by the tea bag of traditional Chinese medicine will be perfected and solved gradually. With the further research and improvement of the prescription of the Chinese medicine bag tea preparation, the Chinese medicine bag tea preparation also has to occupy an important place in a plurality of medicine dosage forms and plays a greater role.
With the improvement of living standard and life style of people, the number of people suffering from diabetes is increasing, and diseases such as hyperlipidemia, hypertension and the like are often combined. Diabetes is a group of metabolic diseases characterized by elevated blood sugar. Hyperglycemia is caused by defective secretion of insulin beta cells or gradual decline of islet function, decreased insulin secretion ability, and decreased effect of regulating blood glucose level. The hyperglycemia of diabetes patients can cause chronic damage and dysfunction of various tissues, particularly eyes, kidneys, hearts, blood vessels and nerves. Diabetes is called as diabetes by traditional Chinese medicine. Diabetes belongs to the category of diabetes in traditional Chinese medicine, and diabetes can be divided into three kinds of diabetes: the main pathological mechanisms of the upper-jiao in the lung, the middle-jiao in the stomach and the lower-jiao in the kidney are yin fluid deficiency, dryness-heat in the interior, yin deficiency as the principal factor and dryness-heat as the secondary factor, which are both causal. Fire excess from yin deficiency can damage qi and yin, and deficiency of both yin and yang can be seen in chronic diseases, which is clinically manifested as deficiency of both qi and yin. Symptoms of dry mouth, thirst, asthenia, polyphagia, hunger, dysphoria with smothery sensation in chest, constipation, palpitation, short breath, spontaneous perspiration, night sweat, red and little body fluid on the tongue, fat and large tongue, and wiry, thready or thready and rapid pulse. Deficiency fire is generated internally due to yin deficiency, and burns body fluid, so that consumption of body fluid cannot be improved, and dry mouth and thirst are seen; the deficient fire disturbing the heart causes dysphoria with smothery sensation in the five centers; stomach fire of deficiency type can eliminate food and allay hunger; constipation due to yin deficiency and intestinal dryness; yellow urine due to deficient fire in the lower energizer. Deficiency fire consumes qi, and deficiency of middle-jiao causes lassitude and hypodynamia; insomnia and amnesia due to kidney qi deficiency; palpitation and shortness of breath due to heart-qi deficiency; ying-wei disharmony can induce spontaneous sweating and night sweat. The tongue with red and dry body is the manifestation of yin deficiency and dryness-heat. Aiming at the pathogenesis and mechanism of diabetes, the fourth batch of Beijing old traditional Chinese medicine experts inherit the academic experience of the work guide teacher, the professor of summer army of famous apricot Ling and professor of summer army and the like provides a method for tonifying qi and promoting the secretion of saliva to treat diabetes, and then through years of clinical practice, the fourth batch of Beijing old traditional Chinese medicine experts follow the principle of diagnosis and treatment based on syndrome differentiation of traditional Chinese medicine, and the fourth batch of Beijing old traditional Chinese medicine experts developed the novel medicinal tea powder on the basis of the frequently-used formula which is drawn by the famous old traditional Chinese medicine experts based on the theory of 'deficiency of yin and excess of yang' of. The prescription composition comprises American ginseng, astragalus root, ophiopogon root, wolfberry fruit, fingered citron and the like. For years, has better curative effect on diabetes (diabetes, diabetes insipidus) with deficiency of both qi and yin and complications in cardiovascular and other aspects. Clinical observation and experimental research on the treatment of diabetes by powder for benefiting qi and promoting the production of body fluid obtain the prize of scientific and technological progress in Beijing City in 1994. In the formula, American ginseng and astragalus root all have the effects of nourishing yin, tonifying qi and promoting the production of body fluid, and the ophiopogon root and the wolfberry fruit have the effects of moistening lung, clearing stomach, nourishing kidney, nourishing yin and clearing heat. The whole formula has the effects of benefiting qi and nourishing yin, promoting the production of body fluid to quench thirst, moistening lung and clearing stomach, nourishing kidney and calming heart. The traditional Chinese medicine composition is clinically applied for 30 years at present, and modern pharmacological studies suggest that the traditional Chinese medicine composition has the effects of reducing blood sugar, strengthening heart, resisting blood platelet, resisting anoxia, increasing coronary blood flow, protecting heart and blood vessels and improving myocardial ischemia.
"Yin is often deficient, while yang is often redundant. "is the main view of Jinyuan four famous families, Zhudanxi, and is suitable for most people in the modern life. For example, the modern life who injures yin even though people want to consume essence and accumulate chronic diseases or cancer radiotherapy and chemotherapy diet are not adjusted to be changed in seasons of strong ultraviolet radiation can quickly live more than the former life who has the disadvantages of a plurality of times of excessive mental consumption and physical strength, especially obvious stamina, and often staying up to night and sleep deficiency, and the long time of liking spicy stimulation taste on diet can cause the vegetative nerve disorder of the human body to be easily suffered from yin deficiency. Yin refers to body fluid in vivo, including blood, digestive juice, saliva, tear water, semen, endocrine and oil secretion, etc., which is a basic substance for human life activities and is very important for the old and the young of men and women. Yin deficiency manifests as yin fluid deficiency, leading to water deficiency: halitosis, oral ulcer, constipation, dry eyes, dry nose, dry mouth, dry throat, pachylosis, dry hair, etc. Typical symptoms of the disease are vexation, irritability, insomnia, dreaminess, dizziness, soreness of waist and knees, frequent micturition, rapid heartbeat, night sweat, feverish palms and soles, tinnitus, etc. In addition, the disease is also easy to cause 'fire', which is manifested by impatience of sexual desire, easy fluctuation of mood, and 'fire-qi' coming from motionless movement, and belongs to the pathological changes of yin and body fluid dryness caused by a large consumption of body fluid, and the vital signs are needed to be timely treated to nourish yin and supplement body fluid. If the treatment is not performed in time, serious diseases such as hypertension and diabetes can develop. The yin nourishing and the body fluid production promoting can relieve the yin deficiency of patients, especially white-collar workers in cities and middle-aged and old people, if the yin can be timely nourished, not only can the occurrence of yin deficiency symptoms be prevented, but also the existing adverse symptoms can be regulated, and the treatment effect is achieved. The commonly used traditional Chinese medicines with the efficacies of nourishing yin, clearing heat and promoting fluid production comprise: rehmannia root, asparagus root, lilyturf root, dendrobium and the like can be selected. Rehmannia root, radix rehmanniae, recorded in Bencao gang mu, has the functions of enhancing immunity, inhibiting tumor growth, reducing blood sugar, regulating blood pressure, promoting bone marrow hematopoiesis, regulating endocrine and the like, and is also a common traditional Chinese medicine for beautifying, moisturizing and delaying senility.
At present, although a plurality of medicines for nourishing yin and promoting the secretion of saliva are available on the market, the requirements of patients cannot be met. Some drugs have slow effect and poor curative effect; some injections have quick response and good curative effect, but patients cannot carry out the injections by themselves, and the injections are inconvenient to use and carry; some chemical medicines can only be used for symptomatic treatment, cannot be used for treating the pathogeny, are not thorough in treatment and have large side effects. People's health care consciousness is continuously improved, and the desire for early prevention of diabetes is gradually strengthened, so that a pure natural traditional Chinese medicine tea bag which has no side effect, takes effect quickly and has the effects of tonifying qi, recovering pulse, nourishing yin and promoting the production of body fluid is urgently needed in the market.
Disclosure of Invention
The invention aims to provide a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid, and the product has the effects of tonifying qi, recovering pulse, nourishing yin, promoting production of body fluid and improving body immunity.
The purpose of the invention is realized by the following technical scheme:
a traditional Chinese medicine tea bag containing radix ophiopogonis, honey-fried licorice root, qi-tonifying, pulse-recovering, yin-nourishing and body fluid-generating is prepared by processing raw materials according to the following weight parts, 40-80 parts of radix ophiopogonis, 20-40 parts of honey-fried licorice root, 20-40 parts of wintercreeper, 80-120 parts of ginseng, 40-80 parts of Chinese magnoliavine fruit, 10-20 parts of pink reineckea herb, 20-30 parts of tremella, 20-30 parts of polygala fallax hemsl, 10-20 parts of aleppo avens, 10-20 parts of cochinchnese asparagus root, 10-20 parts of prepared rehmannia root, 10-20 parts of mulberry, 10-20 parts of dendrobium, 20-30 parts of trichosanthes root, 10-20 parts of kudzuvine root, 10-20 parts of roughhaired holly root, 10-20 parts of Chinese.
A traditional Chinese medicine tea bag containing radix ophiopogonis, honey-fried licorice root, qi-tonifying, pulse-recovering, yin-nourishing and body fluid-generating is prepared by processing 40-60 parts of radix ophiopogonis, 20-30 parts of honey-fried licorice root, 20-30 parts of wintersweet vine, 80-100 parts of ginseng, 40-60 parts of Chinese magnoliavine fruit, 10-15 parts of pink reineckea herb, 20-25 parts of tremella, 20-25 parts of polygala fallax hemsl, 10-15 parts of aleppo avens, 10-15 parts of cochinchnese asparagus root, 10-15 parts of prepared rehmannia root, 10-15 parts of mulberry, 10-15 parts of dendrobium, 20-25 parts of trichosanthes root, 10-15 parts of kudzuvine root, 10-18 parts of roughhaired holly root, 10-18 parts of Chinese olive, 10-15 parts of reed rhizome.
A traditional Chinese medicine tea bag containing radix ophiopogonis, honey-fried licorice root, qi-tonifying, pulse-recovering, yin-nourishing and body fluid-producing is prepared by processing raw materials according to the following preferred weight parts, 60-80 parts of radix ophiopogonis, 30-40 parts of honey-fried licorice root, 30-40 parts of wintercreeper, 120 parts of ginseng 100, 60-80 parts of schisandra chinensis, 15-20 parts of pink reineckea herb, 25-30 parts of tremella, 25-30 parts of polygala fallax hemsl, 15-20 parts of aleppo avens, 15-20 parts of cochinchnese asparagus root, 15-20 parts of prepared rehmannia root, 15-20 parts of mulberry, 15-20 parts of dendrobium, 25-30 parts of trichosanthes root, 15-20 parts of kudzuvine root, 15-20 parts of roughhaired holly root, 15-20 parts of Chinese olive, 15-.
The traditional Chinese medicine tea bag is prepared by processing 60 parts of radix ophiopogonis, 30 parts of radix glycyrrhizae preparata, 40 parts of euonymus fortune, 100 parts of ginseng, 60 parts of schisandra chinensis, 10 parts of reineckea carnea, 20 parts of tremella, 30 parts of polygala fallax hemsl, 10 parts of aleppo avens, 20 parts of radix asparagi, 20 parts of prepared rehmannia root, 10 parts of mulberry, 10 parts of dendrobe, 20 parts of trichosanthes root, 10 parts of kudzuvine root, 10 parts of roughhaired holly root, 10 parts of fructus chebulae immaturus, 10 parts of reed root and 20 parts of Chinese pulsatilla flower according to the optimal weight part ratio.
A traditional Chinese medicine tea bag containing radix ophiopogonis, radix glycyrrhizae preparata, ginseng, schisandra chinensis, pink reineckea herb, tremella 25, polygala fallax hemsl 25, aleppo avens 20, radix asparagi 20, prepared rehmannia root 20, mulberry 15, dendrobium nobile 15, trichosanthes root 25, kudzuvine root 15, roughhaired holly root 15, Chinese olive 15, reed rhizome 15, Chinese pulsatilla flower 15, thyme 15 and caulis sinomenii 15 is processed and prepared from the following raw materials in a preferable weight ratio.
A preparation method of a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid comprises the following steps:
step 1, cleaning and removing impurities from traditional Chinese medicine raw materials
According to the weight ratio of the traditional Chinese medicine raw materials, respectively cleaning the traditional Chinese medicine raw materials of radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower, and removing impurities;
step 2, drying, crushing and sterilizing the traditional Chinese medicine raw materials
Drying the purified traditional Chinese medicine raw materials in a drying box at 90-100 ℃ for 100 minutes; then respectively putting radix Ophiopogonis, radix Glycyrrhizae Preparata, caulis Seu folium Euonymi Fortunei, Ginseng radix, fructus Schisandrae chinensis, herba Reineckeae Carneae, Tremella, herba Polygalae Fallacis, herba Gei Nervosae, radix asparagi, radix rehmanniae Preparata, Mori fructus, herba Dendrobii, Trichosanthis radix, radix Puerariae Lobatae, radix Ilicis Asprellae, fructus Chebulae, rhizoma Phragmitis, and flos Pulsatillae into a pulverizer, pulverizing into 14-40 mesh granules, and sterilizing by irradiating with ultraviolet lamp for 60 min to obtain granules;
step 3, mixing the crushed and sterilized radix ophiopogonis, honey-fried licorice root, wintercreeper, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium, trichosanthes root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower particles in proportion, adding crystal sugar, fully stirring and uniformly mixing;
step 4, packaging the uniformly mixed traditional Chinese medicine mixed particles into 4g of bagged tea bags to obtain traditional Chinese medicine bagged tea;
step 5, sterilizing and inspecting
And (4) sterilizing the traditional Chinese medicine teabag obtained in the step (4) by using an ultrahigh-temperature instant sterilizer at the temperature of 120 ℃ for 2-8 seconds, cooling, packaging, inspecting and leaving the factory to obtain the traditional Chinese medicine teabag with the effects of tonifying qi, recovering pulse, nourishing yin and promoting the secretion of saliva or body fluid.
Among the raw materials, Mai Dong is slightly cold in nature, sweet and slightly bitter in taste. It enters heart, lung and stomach meridians, and has effects of nourishing yin, promoting fluid production, moistening lung, clearing heart fire, and protecting cardiovascular system for treating dry cough due to lung dryness, hematemesis, pulmonary abscess, consumptive disease, dysphoria, thirst, fever, body fluid injury, dry throat, dry mouth, constipation, etc.; enhancing hypoxia tolerance and prolonging the survival time of hypoxia under normal pressure; enhancing immune function; reducing blood sugar; delaying aging; inhibiting gastrointestinal propulsion; and (4) resisting bacteria. The radix ophiopogonis is a good medicine for nourishing yin and moistening lung, and has a good effect of reducing blood sugar in recent years; the clinical application has stable cardiac effect and good effect. Experiments also prove that the water-soluble polysaccharide in the dwarf lilyturf tuber has the functions of resisting anoxia and promoting immunity.
Prepared licorice root, radix Glycyrrhizae Praeparata, warm in nature, sweet in flavor. Enters heart, lung, stomach and spleen channels, and has effects of invigorating spleen and regulating stomach function, invigorating qi and recovering pulse, and can be used for treating weakness of spleen and stomach, listlessness debilitation, cardiopalmus, and intermittent pulse.
Fufangteng, mild in nature and slightly bitter in taste, enters liver channel, spleen channel and kidney channel, can replenish qi and blood, tonify liver and kidney, relax tendons and activate collaterals, and is used for treating qi and blood weakness, lumbar muscle strain, rheumatic arthralgia, traumatic fracture and traumatic hemorrhage; eucommia bark, cortex Eucommiae, tonify liver and kidney, strengthen tendons and bones, is mainly used for treating lumbago due to kidney deficiency, flaccidity and weakness of lower limbs, impotence, frequent micturition, threatened abortion;
luckiness herb, cool in nature, sweet in taste. It is used to treat cough due to lung heat, hematemesis, pulmonary tuberculosis, acute and chronic bronchitis, asthma, icteric hepatitis, chronic pyelonephritis, spermatorrhea, traumatic injury, skin sore, and fracture.
Tremella fuciformis is neutral in nature and sweet in taste. It has effects of moistening lung, promoting fluid production, nourishing yin, invigorating stomach, invigorating qi, regulating blood, nourishing marrow, tonifying heart, clearing lung heat, and relieving kidney dryness, and can be used for treating cough due to lung heat, dry cough due to lung dryness, chronic cough, itching throat, phlegm with blood, chronic cough, costalgia, lung carbuncle, lung flaccidity, menoxenia, gastritis, constipation, and hematochezia.
Huanghua water Lian is neutral in nature, sweet in flavor and slightly bitter in taste. It enters liver meridian, kidney meridian and spleen meridian, and has the actions of benefiting qi, nourishing blood, invigorating spleen, promoting diuresis, promoting blood circulation and regulating menstruation, and is used in treating body deficiency, soreness of waist and knees, edema due to spleen deficiency and excessive dampness, leukorrhagia, menoxenia due to blood deficiency and blood stasis, and swelling and pain due to traumatic injury.
Blue cloth, cool in nature, sweet and slightly bitter in taste. The traditional Chinese medicine composition enters liver channel, spleen channel and lung channel, and has the effects of tonifying qi and spleen, enriching blood and yin, moistening lung and reducing phlegm, and is used for treating deficiency of qi and blood, consumptive disease, cough, spleen deficiency and leukorrhagia.
Tian Dong is cold in nature, sweet and bitter in taste. Entering lung and kidney meridians, nourishing yin to moisten dryness, moistening lung and promoting fluid production, and is indicated for dry cough due to lung heat, cough with sticky phlegm, dry throat and thirst, constipation due to intestinal dryness.
Shu Di Huang is slightly warm in nature and sweet in flavor. Enters liver and kidney meridians, and has effects of replenishing blood, nourishing yin, replenishing vital essence, and replenishing marrow, and can be used for treating blood deficiency and chlorosis, cardiopalmus, menoxenia, metrorrhagia and metrostaxis, liver and kidney yin deficiency, soreness and weakness of waist and knees, hectic fever due to yin deficiency, night sweat, nocturnal emission, internal heat, and diabetes.
Mulberry fruit, mulberry fruit, cold in nature, sweet in taste and sour. It enters heart, liver and kidney meridians, and has the actions of tonifying blood, nourishing yin, promoting fluid production and moistening dryness, so it is indicated for vertigo, tinnitus, palpitation, insomnia, early white hair, thirst due to body fluid consumption, internal heat, diabetes, blood deficiency and constipation. Dizziness, tinnitus and premature graying of hair.
Dendrobe is slightly cold in nature and sweet in taste. It enters stomach and kidney meridians, tonifies stomach and generates body fluid, and nourishes yin and clears heat, so it is indicated for yin deficiency and fluid deficiency, dry mouth with polydipsia, poor appetite and retching, deficiency heat after illness, and dim and unclear vision.
Trichosanthis radix is slightly cold in nature, sweet and slightly bitter in taste. It enters lung and stomach meridians, and has actions of clearing heat, promoting fluid production, relieving swelling and pus discharge, so it is indicated for feverish sensation with polydipsia, dry cough due to lung heat, diabetes due to internal heat, sores and ulcers, and pyogenic infections.
Kudzuvine root, pungent in nature; bitter; flat, lung; stomach meridian, clearing heat and promoting eruption; produce saliva and quench thirst. Mainly treats cold and fever; measles without adequate eruption; quenching thirst; hematemesis; aphtha.
Roughhaired holly root, bitter and sweet in taste and cool in nature. It enters lung channel, liver channel and large intestine channel, has effects of clearing heat and detoxicating, promoting fluid production to quench thirst, relieving sore throat and detumescence, removing blood stasis and relieving pain, has antibacterial effect, and can be used for treating common cold and fever, lung heat cough, fever body fluid consumption thirst, and laryngopharynx swelling and pain. Proper dosage for external use is indicated for swelling and pain due to blood stasis in trauma.
Xiqingguo is mild in nature, bitter, slightly sweet and astringent in taste. It enters lung and large intestine meridians, and has the actions of clearing heat, promoting fluid production, relieving sore throat and removing toxicity, and is used to treat chronic pharyngolaryngitis, hoarseness and dry throat.
Reed rhizome, cold in nature, sweet in taste. Enters lung and stomach meridians, has effects of clearing heat, promoting fluid production, relieving restlessness, relieving vomit, and promoting urination, and can be used for treating fever polydipsia, stomach heat vomiturition, lung heat cough, lung carbuncle, purulence, heat stranguria and pain with astringency.
Cleistocalyx operculatus flower, cold in nature, bitter in taste. It enters lung, spleen and stomach meridians, and has the actions of clearing away summer-heat, promoting the production of body fluid to quench thirst, removing dampness and resolving stagnation, so it is indicated for fever, dry throat, thirst, abdominal distention or vomiting and diarrhea due to summer-heat and food stagnation.
The invention has the beneficial effects that: the invention provides a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine bag tea for tonifying qi, recovering pulse, nourishing yin and promoting fluid production, which is prepared from radix ophiopogonis, honey-fried licorice root, euonymus fortunei, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax bunge, aleppo avens, radix asparagi, prepared rehmannia root, mulberry, dendrobium nobile, radix trichosanthis, kudzuvine root, roughhaired holly root, fructus terminaliae immaturus, reed rhizome, Chinese pulsatilla flower and the like, and the product has the effects of tonifying qi, recovering pulse, nourishing yin and promoting fluid production, improves the immunity of the organism, and can effectively treat diseases such as deficiency of qi and blood, dizziness, insomnia, amnes; compared with Chinese patent medicine, has the advantages of wide treatment range, quick response, simple preparation, convenient eating, rich nutrition, easy absorption and the like.
Detailed Description
Example 1
A traditional Chinese medicine tea bag containing radix ophiopogonis, radix glycyrrhizae preparata, qi tonifying, pulse recovering, yin nourishing and body fluid production promoting is prepared by processing raw materials according to the following weight parts, 40 parts of radix ophiopogonis, 20 parts of radix glycyrrhizae preparata, 20 parts of euonymus fortunei, 80 parts of ginseng, 40 parts of schisandra chinensis, 10 parts of pink reineckea herb, 20 parts of tremella, 20 parts of polygala fallax hemsl, 10 parts of aleppo avens, 10 parts of radix asparagi, 10 parts of prepared rehmannia root, 10 parts of mulberry, 10 parts of dendrobe, 20 parts of trichosanthes root, 10 parts of kudzuvine root, 10 parts of roughhaired holly root, 10 parts of fructus che.
A preparation method of a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid comprises the following steps:
step 1, cleaning and removing impurities from traditional Chinese medicine raw materials
According to the weight ratio of the traditional Chinese medicine raw materials, respectively cleaning the traditional Chinese medicine raw materials of radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower, and removing impurities;
step 2, drying, crushing and sterilizing the traditional Chinese medicine raw materials
Drying the purified traditional Chinese medicine raw materials in a drying box at 90 ℃ for 100 minutes; then respectively putting radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, Chinese magnoliavine fruit, pink reineckea herb, tremella, manglietia fallax bunge, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower into a grinder to be ground into 14-mesh particles, and irradiating the particles for 60 minutes by using an ultraviolet lamp to carry out sterilization to obtain the particles;
step 3, mixing the crushed and sterilized radix ophiopogonis, honey-fried licorice root, wintercreeper, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium, trichosanthes root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower particles in proportion, adding crystal sugar, fully stirring and uniformly mixing;
step 4, packaging the uniformly mixed traditional Chinese medicine mixed particles into 4g of bagged tea bags to obtain traditional Chinese medicine bagged tea;
step 5, sterilizing and inspecting
And (4) sterilizing the traditional Chinese medicine teabag obtained in the step (4) by using an ultrahigh-temperature instant sterilizer at the temperature of 120 ℃ for 5 seconds, cooling, packaging, inspecting and leaving the factory to obtain the traditional Chinese medicine teabag with the effects of tonifying qi, recovering pulse, nourishing yin and promoting the secretion of saliva or body fluid.
Example 2
A traditional Chinese medicine tea bag containing radix ophiopogonis, radix glycyrrhizae preparata, qi tonifying, pulse recovering, yin nourishing and body fluid production promoting is prepared by processing raw materials according to the following preferable weight parts, wherein the raw materials comprise 70 parts of radix ophiopogonis, 30 parts of radix glycyrrhizae preparata, 20 parts of wintersweet stems, 90 parts of ginseng, 45 parts of schisandra chinensis, 12 parts of Reineckia carnea, 25 parts of tremella, 25 parts of radix polygalae fallax, 12 parts of aleppo avens, 12 parts of radix asparagi, 10 parts of prepared rehmannia roots, 15 parts of mulberries, 15 parts of dendrobe, 25 parts of trichosanthes roots, 12 parts of kudzuvine roots, 10 parts of roughhaired holly roots, 18 parts.
A preparation method of a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid comprises the following steps:
step 1, cleaning and removing impurities from traditional Chinese medicine raw materials
According to the weight ratio of the traditional Chinese medicine raw materials, respectively cleaning the traditional Chinese medicine raw materials of radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower, and removing impurities;
step 2, drying, crushing and sterilizing the traditional Chinese medicine raw materials
Drying the purified traditional Chinese medicine raw materials in a drying box at 95 ℃ for 100 minutes; then respectively putting radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, Chinese magnoliavine fruit, pink reineckea herb, tremella, polygala fallax hemsl, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower into a grinder to be ground into 20-mesh particles, and irradiating the particles for 60 minutes by using an ultraviolet lamp to carry out sterilization to obtain the particles;
step 3, mixing the crushed and sterilized radix ophiopogonis, honey-fried licorice root, wintercreeper, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium, trichosanthes root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower particles in proportion, adding crystal sugar, fully stirring and uniformly mixing;
step 4, packaging the uniformly mixed traditional Chinese medicine mixed particles into 4g of bagged tea bags to obtain traditional Chinese medicine bagged tea;
step 5, sterilizing and inspecting
And (4) sterilizing the traditional Chinese medicine teabag obtained in the step (4) by using an ultrahigh-temperature instant sterilizer at the temperature of 120 ℃ for 6 seconds, cooling, packaging, inspecting and leaving the factory to obtain the traditional Chinese medicine teabag with the effects of tonifying qi, recovering pulse, nourishing yin and promoting the secretion of saliva or body fluid.
Example 3
A traditional Chinese medicine tea bag containing radix ophiopogonis, radix glycyrrhizae preparata, ginseng, schisandra chinensis, pink reineckea herb, 30 tremella, radix polygalae, 20 bluecloth, 20 asparagus cochinchinensis, 20 prepared rehmannia root, 20 mulberry, 20 dendrobium, 30 trichosanthes root, 20 kudzuvine root, 20 roughhaired holly root, 20 Chinese olive, 20 reed rhizome and 20 Chinese pulsatilla flower is processed and prepared from the following raw materials in a preferable weight ratio.
A preparation method of a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid comprises the following steps:
step 1, cleaning and removing impurities from traditional Chinese medicine raw materials
According to the weight ratio of the traditional Chinese medicine raw materials, respectively cleaning the traditional Chinese medicine raw materials of radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower, and removing impurities;
step 2, drying, crushing and sterilizing the traditional Chinese medicine raw materials
Drying the purified traditional Chinese medicine raw materials in a drying box at 100 ℃ for 100 minutes; then respectively putting radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, Chinese magnoliavine fruit, pink reineckea herb, tremella, manglietia fallax bunge, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower into a grinder to be ground into 40-mesh particles, and irradiating the particles for 60 minutes by using an ultraviolet lamp to carry out sterilization to obtain the particles;
step 3, mixing the crushed and sterilized radix ophiopogonis, honey-fried licorice root, wintercreeper, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium, trichosanthes root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower particles in proportion, adding crystal sugar, fully stirring and uniformly mixing;
step 4, packaging the uniformly mixed traditional Chinese medicine mixed particles into 4g of bagged tea bags to obtain traditional Chinese medicine bagged tea;
step 5, sterilizing and inspecting
And (4) sterilizing the traditional Chinese medicine teabag obtained in the step (4) by using an ultrahigh-temperature instant sterilizer at the temperature of 120 ℃ for 7 seconds, cooling, packaging, inspecting and leaving the factory to obtain the traditional Chinese medicine teabag with the effects of tonifying qi, recovering pulse, nourishing yin and promoting the secretion of saliva or body fluid.
Example 4
The traditional Chinese medicine tea bag is prepared by processing 60 parts of radix ophiopogonis, 30 parts of radix glycyrrhizae preparata, 40 parts of euonymus fortune, 100 parts of ginseng, 60 parts of schisandra chinensis, 10 parts of reineckea carnea, 20 parts of tremella, 30 parts of polygala fallax hemsl, 10 parts of aleppo avens, 20 parts of radix asparagi, 20 parts of prepared rehmannia root, 10 parts of mulberry, 10 parts of dendrobe, 20 parts of trichosanthes root, 10 parts of kudzuvine root, 10 parts of roughhaired holly root, 10 parts of fructus chebulae immaturus, 10 parts of reed root and 20 parts of Chinese pulsatilla flower according to the optimal weight part ratio.
A preparation method of a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid comprises the following steps:
step 1, cleaning and removing impurities from traditional Chinese medicine raw materials
According to the weight ratio of the traditional Chinese medicine raw materials, respectively cleaning the traditional Chinese medicine raw materials of radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower, and removing impurities;
step 2, drying, crushing and sterilizing the traditional Chinese medicine raw materials
Drying the purified traditional Chinese medicine raw materials in a drying box at 100 ℃ for 100 minutes; then respectively putting radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, Chinese magnoliavine fruit, pink reineckea herb, tremella, manglietia fallax bunge, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower into a grinder to be ground into 40-mesh particles, and irradiating the particles for 60 minutes by using an ultraviolet lamp to carry out sterilization to obtain the particles;
step 3, mixing the crushed and sterilized radix ophiopogonis, honey-fried licorice root, wintercreeper, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium, trichosanthes root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower particles in proportion, adding crystal sugar, fully stirring and uniformly mixing;
step 4, packaging the uniformly mixed traditional Chinese medicine mixed particles into 4g of bagged tea bags to obtain traditional Chinese medicine bagged tea;
step 5, sterilizing and inspecting
And (4) sterilizing the traditional Chinese medicine teabag obtained in the step (4) by using an ultrahigh-temperature instant sterilizer at the temperature of 120 ℃ for 5 seconds, cooling, packaging, inspecting and leaving the factory to obtain the traditional Chinese medicine teabag with the effects of tonifying qi, recovering pulse, nourishing yin and promoting the secretion of saliva or body fluid.
Example 5
A traditional Chinese medicine tea bag containing radix ophiopogonis, radix glycyrrhizae preparata, ginseng, schisandra chinensis, pink reineckea herb, tremella 25, polygala fallax hemsl 25, aleppo avens 20, radix asparagi 20, prepared rehmannia root 20, mulberry 15, dendrobium nobile 15, trichosanthes root 25, kudzuvine root 15, roughhaired holly root 15, Chinese olive 15, reed rhizome 15, Chinese pulsatilla flower 15, thyme 15 and caulis sinomenii 15 is processed and prepared from the following raw materials in a preferable weight ratio.
A preparation method of a radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid comprises the following steps:
step 1, cleaning and removing impurities from traditional Chinese medicine raw materials
According to the weight ratio of the traditional Chinese medicine raw materials, respectively cleaning the traditional Chinese medicine raw materials of radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower, and removing impurities;
step 2, drying, crushing and sterilizing the traditional Chinese medicine raw materials
Drying the purified traditional Chinese medicine raw materials in a drying box at 100 ℃ for 100 minutes; then respectively putting radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, Chinese magnoliavine fruit, pink reineckea herb, tremella, manglietia fallax bunge, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower into a grinder to be ground into 40-mesh particles, and irradiating the particles for 60 minutes by using an ultraviolet lamp to carry out sterilization to obtain the particles;
step 3, mixing the crushed and sterilized radix ophiopogonis, honey-fried licorice root, wintercreeper, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium, trichosanthes root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower particles in proportion, adding crystal sugar, fully stirring and uniformly mixing;
step 4, packaging the uniformly mixed traditional Chinese medicine mixed particles into 4g of bagged tea bags to obtain traditional Chinese medicine bagged tea;
step 5, sterilizing and inspecting
And (4) sterilizing the traditional Chinese medicine teabag obtained in the step (4) by using an ultrahigh-temperature instant sterilizer at the temperature of 120 ℃ for 8 seconds, cooling, packaging, inspecting and leaving the factory to obtain the traditional Chinese medicine teabag with the effects of tonifying qi, recovering pulse, nourishing yin and promoting the secretion of saliva or body fluid.
First, routine examination
The teabags prepared in examples 1 to 5 were left at room temperature for 24 months. The microbiological tests were carried out according to the standard (GB/T22474) and the results are shown in Table 1.
Table 1: results of microbial detection
And (4) conclusion: no pathogenic bacteria were detected.
Second, toxicology test of drugs
1. Acute toxicity test
The teabag prepared in the embodiment 5 of the invention is used as a test, a gastric lavage administration mode is adopted, continuous administration is carried out for 2 times within 24 hours, each time interval is more than 4 hours, each administration time is 50g crude drug, and the total accumulated drug amount reaches 100g crude drug/kg, which is equivalent to 50 times of the clinical dosage of a human. Within 7d after administration, the mice had normal activity, feeding and excretion, good growth and bright hair color, and the average body weight of the mice increased with the lapse of the experimental time. After 8d of sacrifice, each mouse was dissected and visually observed to find no color or morphological abnormality in the heart, liver, spleen, lung, kidney, brain, thymus, stomach, intestine, etc., and half of the lethal dose could not be measured (LD 50). The results show that: the traditional Chinese medicine has no acute toxic reaction.
2. Long term toxicity test
The teabag prepared in the embodiment 5 of the invention is used as a test, the traditional Chinese medicine is divided into three groups of low dose, medium dose and high dose by adopting a gastric lavage administration mode, and the dosage of each group of medicine is respectively 10, 30 and 50g of crude medicine/kg/d, which is equivalent to 10, 30 and 50 times of clinical dose. After 24 weeks of gastric administration, the traditional Chinese medicine has no obvious influence on the general condition, hematological indexes and blood biochemical indexes of animals, and abnormal pathological changes are not found in the system anatomy, organ coefficients and histopathological examination. No obvious change is seen after the medicine is stopped for 2 weeks. The results show that: in a long-term toxicity test, the traditional Chinese medicine disclosed by the invention has no obvious toxic reaction or delayed toxic reaction. Therefore, the traditional Chinese medicine has no toxic reaction and is safe and reliable for long-term administration.
3. Safety test
Female and male mice are selected by a Hohner method, and a one-time oral acute toxicity test is respectively carried out on the products of examples 1 to 5, so that the result is that the female mice LD50=5.84 (4.30-7.94) g/kg; male mouse LD50=5.01 (3.44-7.3) g/kg. According to the evaluation procedure and method of food safety toxicology, the grading standard of oral acute toxicity shows that the oral acute toxicity is non-toxic. The femoral bone marrow micronucleus test of examples 1-5 was conducted in female and male mice at three doses of 5g/kg, 2.5g/kg, and 1.25g/kg, respectively. And additionally arranging a negative control group of distilled water and a positive control group (cyclophosphamide 50 mg/kg), wherein the experimental result shows that: the micronucleus test is a negative result. Healthy adult male mice were selected for mouse teratospermia tests on the products of examples 1-5, given three dose groups of 4g/kg, 2g/kg, and 1 g/kg. A negative control group, distilled water and a positive control group (mitomycin 2.5 g/kg) were additionally provided. Through statistical treatment, the difference between the sperm aberration rate and the negative sperm aberration rate of each dose group is not significant (P > 0.05), and the difference between the sperm aberration rate of the negative control and the sperm aberration rate of the positive control is very significant (P < 0.01). Indicating that the teratospermia test belongs to a negative result. The safety can be ensured.
And thirdly, NR8383 rat alveolar macrophages purchased from the cell bank of Chinese academy of sciences. The culture medium used was F12K medium (SIGMA, cat # N3520, supplemented with NaHCO32.5g/L), 80%; fetal bovine serum, 20%. The culture was expanded at 37 ℃.
Examples 1-5 tea bags were each placed in 250 ml of distilled water and kept at room temperature for 2 hours. It was boiled at 80 ℃ for 1 hour and brought to a volume of 10 ml. The supernatant was filtered through a 0.22 μm filter.
NR8383 rat alveolar macrophages were coated on the coverslips at a density of 105 cells/coverslip and allowed to adhere. The bagged tea prepared in examples 1-5 was dissolved to obtain supernatant and cultured. After incubation, cells were incubated with 106 latex beads/105 cells (cell: beads ═ 1: 10) for 2 hours. Cells on the coverslip were air dried and fixed with methanol. Cells were stained by Giemsa for 10 min and counted microscopically. The results of the macrophage phagocytosis assay are expressed as the phagocytosis index, i.e., the total number of beads within the cell per 100 cells. Data analyzed using statistical methods showed confidence levels greater than 95% in the t-test.
TABLE 2 results of macrophage phagocytosis assay
Medicine Concentration in the culture Medium Index of phagocytosis
Example 1 0.01±0.001 1.13
Example 2 0.01±0.001 1.11
Example 3 0.01±0.001 1.50
Practice ofExample 4 0.01±0.001 1.43
Example 5 0.01±0.001 1.55
Therefore, the components of the traditional Chinese medicine teabag provided by the invention are synergistic, and the effect of enhancing immunity is reflected.
Fourthly, the main functions and treatment ranges of the medicine are as follows:
1. the main functions are as follows:
the health-care tea has the effects of tonifying qi and restoring pulse, tonifying qi and yin, promoting the production of body fluid to quench thirst, and relieving restlessness and dysphoria, is used for treating dizziness, insomnia and amnesia, myasthenia of limbs, deficiency of qi and blood, dry throat and thirst, and constipation due to intestinal dryness caused by deficiency of both qi and yin, can effectively improve the deficiency of body qi, enhance the memory, improve the immunity and competitive power of human bodies, and quickly improve the working efficiency.
2. Application and dosage
The medicine is taken after meals, 100 ml is taken every time, 2 times a day, and 14 days are a treatment course.
3. Clinical observation of the medicine of the invention:
(1) clinical symptoms
Can be used for treating dizziness, insomnia, amnesia, myasthenia of limbs, deficiency of qi and blood, dry throat, thirst, and constipation;
(2) general data
Meets the clinical symptoms; the age is between 20 and 75 years old, and the male and the female are not limited; the external medicine related to the disease is not used within 2 weeks, and any internal medicine for treating the disease is not used within 4 weeks; the functions of important visceral organs and tissues are basically normal, and 200 patients meeting the selection standard of the research are selected; an informed consenting person;
(3) rejection and abort criteria:
firstly, the medicine is not taken according to a scheme, so that the judgment of effectiveness and safety is influenced;
quit the person in the research process;
and thirdly, the data is incomplete, which affects the judgment of effectiveness and safety.
Fourthly, serious adverse reactions occur in the treatment process.
4. The observation method comprises the following steps:
(1) case grouping:
randomly dividing the selected cases into 2 groups of treatment groups and control groups by adopting a random and control method, wherein each group comprises 100 persons;
(2) the treatment method comprises the following steps:
treatment groups: the tea bag is externally used for 2 times a day, is taken after meals and is taken after being mixed with warm boiled water, 100 milliliters of the tea bag is taken each time, and 14 days are 1 course of treatment; control group: the externally applied ginseng five-treasure sealwort tea of Nanjing Tongrentang is taken after meals, and is taken with warm boiled water, 100 milliliters each time, 2 times a day, and 14 days as 1 course of treatment;
(3) recording the condition: the patient is observed once a week, and the change of the patient's condition is recorded in time.
TABLE 3 comparison of the two treatment courses before and after use (unit: human)
As a result: 100 treatment groups have the effective rate of 88.9 percent for improving the dizziness, 86.5 percent for improving the insomnia and the amnesia, 93.8 percent for improving the myasthenia of limbs, 97.6 percent for improving the deficiency of qi and blood, 85.7 percent for improving the dry throat and thirst and 87.0 percent for improving the dry intestine and constipation; compared with 100 cases in the control group, the effective rate of improving the dizziness condition is 81.3 percent, the effective rate of improving the insomnia and amnesia condition is 81.0 percent, the effective rate of improving the myasthenia of limbs is 90.0 percent, the effective rate of improving the deficiency of qi and blood is 92.06 percent, the effective rate of improving the dry throat and thirst condition is 93.3 percent, and the effective rate of improving the dry intestine and constipation condition is 86.9 percent; as can be seen from the treatment results, the treatment effect of the treatment group was superior to that of the control group.
And (4) conclusion: in the treatment process, no adverse reaction occurs, and the medicine is safe. Clinical observation proves that the invention has better curative effects on dizziness, insomnia, amnesia, myasthenia of limbs, deficiency of qi and blood, dry throat, thirst, intestinal dryness, constipation and other symptoms.
This summary merely illustrates some embodiments which are claimed, wherein one or more of the features recited in the claims can be combined with any one or more of the embodiments, and such combined embodiments are also within the scope of the present disclosure as if they were specifically recited in the disclosure.

Claims (6)

1. A radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 40-80 parts of radix ophiopogonis, 20-40 parts of honey-fried licorice root, 20-40 parts of wintersweet vine, 80-120 parts of ginseng, 40-80 parts of schisandra chinensis, 10-20 parts of reineckia carnea, 20-30 parts of tremella, 20-30 parts of polygala fallax hemsl, 10-20 parts of aleppo avens, 10-20 parts of radix asparagi, 10-20 parts of prepared rehmannia root, 10-20 parts of mulberry, 10-20 parts of dendrobe, 20-30 parts of trichosanthes root, 10-20 parts of kudzuvine root, 10-20 parts of roughhaired holly root, 10-20 parts of fructus chebulae immaturus, 10-20 parts of reed rhizome and 10-20 parts of cleisto.
2. The radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid according to claim 1, is characterized in that: the traditional Chinese medicine composition is prepared by processing 40-60 parts of radix ophiopogonis, 20-30 parts of honey-fried licorice root, 20-30 parts of wintersweet vine, 80-100 parts of ginseng, 40-60 parts of schisandra chinensis, 10-15 parts of Reineckea carnea, 20-25 parts of tremella, 20-25 parts of polygala fallax hemsl, 10-15 parts of aleppo avens, 10-15 parts of radix asparagi, 10-15 parts of prepared rehmannia root, 10-15 parts of mulberry, 10-15 parts of dendrobe, 20-25 parts of trichosanthes root, 10-15 parts of kudzuvine root, 10-18 parts of roughhaired holly root, 10-18 parts of fructus chebulae, 10-15 parts of reed rhizome and 10-15 parts of cleistolochia chinensis flower according to the following optimal.
3. The radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid according to claim 1, is characterized in that: the traditional Chinese medicine composition is prepared by processing raw materials according to the following preferred weight portion ratio, wherein the raw materials comprise, by weight, 60-80 portions of radix ophiopogonis, 30-40 portions of honey-fried licorice root, 30-40 portions of wintersweet vine, 120 portions of ginseng 100, 60-80 portions of schisandra chinensis, 15-20 portions of pink reineckea herb, 25-30 portions of tremella, 25-30 portions of polygala fallax hemsl, 15-20 portions of aleppo avens, 15-20 portions of radix asparagi, 15-20 portions of prepared rehmannia root, 15-20 portions of mulberry, 15-20 portions of dendrobe, 25-30 portions of trichosanthes root, 15-20 portions of kudzuvine root, 15-20 portions of roughhaired holly root, 15-20 portions of fructus chebulae, 15-20 portions of reed rhizome.
4. The radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid according to claim 1, is characterized in that: the traditional Chinese medicine composition is prepared by processing raw materials according to the following preferred weight part ratio, wherein the raw materials comprise 60 parts of dwarf lilyturf tuber, 30 parts of honey-fried licorice root, 40 parts of wintersweet vine, 100 parts of ginseng, 60 parts of Chinese magnoliavine fruit, 10 parts of pink reineckea herb, 20 parts of tremella, 30 parts of polygala fallax hemsl, 10 parts of blue cloth, 20 parts of cochinchnese asparagus root, 20 parts of prepared rehmannia root, 10 parts of mulberry, 10 parts of dendrobium, 20 parts of mongolian snakegourd root, 10 parts of kudzuvine root, 10 parts of roughhaired holly root, 10 parts of Chinese.
5. The radix ophiopogonis and honey-fried licorice root traditional Chinese medicine tea bag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid according to claim 1, is characterized in that: the traditional Chinese medicine composition is prepared by processing the following raw materials, by weight, 50 parts of radix ophiopogonis, 30 parts of honey-fried licorice root, 30 parts of euonymus fortunei, 100 parts of ginseng, 50 parts of schisandra chinensis, 20 parts of pink reineckea herb, 25 parts of tremella, 25 parts of polygala fallax hemsl, 20 parts of aleppo avens, 20 parts of radix asparagi, 20 parts of prepared rehmannia root, 15 parts of mulberry, 15 parts of dendrobium nobile, 25 parts of trichosanthes root, 15 parts of kudzuvine root, 15 parts of roughhaired holly root, 15 parts of fructus chebulae, 15 parts of reed root, 15 parts of Chinese pulsatilla flower, 15 parts of thyme.
6. The radix ophiopogonis and honey-fried licorice root qi-tonifying pulse-recovering, yin-nourishing and body fluid-generating traditional Chinese medicine tea bag according to any one of claims 1 to 5, which is characterized in that: the manufacturing method comprises the following steps:
step 1, cleaning and removing impurities from traditional Chinese medicine raw materials
According to the weight ratio of the traditional Chinese medicine raw materials, respectively cleaning the traditional Chinese medicine raw materials of radix ophiopogonis, honey-fried licorice root, wintersweet vine, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium nobile, mongolian snakegourd root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower, and removing impurities;
step 2, drying, crushing and sterilizing the traditional Chinese medicine raw materials
Drying the purified traditional Chinese medicine raw materials in a drying box at 90-100 ℃ for 100 minutes; then respectively putting radix Ophiopogonis, radix Glycyrrhizae Preparata, caulis Seu folium Euonymi Fortunei, Ginseng radix, fructus Schisandrae chinensis, herba Reineckeae Carneae, Tremella, herba Polygalae Fallacis, herba Gei Nervosae, radix asparagi, radix rehmanniae Preparata, Mori fructus, herba Dendrobii, Trichosanthis radix, radix Puerariae Lobatae, radix Ilicis Asprellae, fructus Chebulae, rhizoma Phragmitis, and flos Pulsatillae into a pulverizer, pulverizing into 14-40 mesh granules, and sterilizing by irradiating with ultraviolet lamp for 60 min to obtain granules;
step 3, mixing the crushed and sterilized radix ophiopogonis, honey-fried licorice root, wintercreeper, ginseng, schisandra chinensis, pink reineckea herb, tremella, manglietia fallax, aleppo avens, cochinchnese asparagus root, prepared rehmannia root, mulberry, dendrobium, trichosanthes root, kudzuvine root, roughhaired holly root, Chinese olive, reed rhizome and Chinese pulsatilla flower particles in proportion, adding crystal sugar, fully stirring and uniformly mixing;
step 4, packaging the uniformly mixed traditional Chinese medicine mixed particles into 4g of bagged tea bags to obtain traditional Chinese medicine bagged tea;
step 5, sterilizing and inspecting
And (4) sterilizing the traditional Chinese medicine teabag obtained in the step (4) by using an ultrahigh-temperature instant sterilizer at the temperature of 120 ℃ for 2-8 seconds, cooling, packaging, inspecting and leaving the factory to obtain the traditional Chinese medicine teabag with the effects of tonifying qi, recovering pulse, nourishing yin and promoting the secretion of saliva or body fluid.
CN201911003972.5A 2019-10-22 2019-10-22 Radix ophiopogonis and honey-fried licorice root traditional Chinese medicine teabag for tonifying qi, recovering pulse, nourishing yin and promoting production of body fluid Pending CN110585361A (en)

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Citations (3)

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Publication number Priority date Publication date Assignee Title
CN103519172A (en) * 2013-10-17 2014-01-22 新疆天海绿洲农业科技股份有限公司 Soft capsule containing jujube, American ginseng and sea buckthorn seed oil
CN108578565A (en) * 2018-05-29 2018-09-28 山东融基健康管理股份有限公司 A kind of cherry three joins comfortable brain tonic medicinal liquor and preparation method thereof
CN109464587A (en) * 2018-11-16 2019-03-15 郭书安 A kind of oral solution for treating hypertension

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103519172A (en) * 2013-10-17 2014-01-22 新疆天海绿洲农业科技股份有限公司 Soft capsule containing jujube, American ginseng and sea buckthorn seed oil
CN108578565A (en) * 2018-05-29 2018-09-28 山东融基健康管理股份有限公司 A kind of cherry three joins comfortable brain tonic medicinal liquor and preparation method thereof
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Application publication date: 20191220

WD01 Invention patent application deemed withdrawn after publication